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PIUS NDE PhD
Affiliation:
Meharry Medical College
Microbiology & Immunology
"Cardiovascular and Related Diseases","Infectious and Immunological
Diseases"
Title: Dr.
Rank: Assistant Professor
Address:
Dept of Microbiology & Immunology Meharry Medical College
Nashville, TN 37208
Contact:
Email: [email protected]
Telephone: 615 327 6997
Narrative
Dr. Pius N. Nde is an Assistant Professor in the Department of Microbiology and Immunology at
Meharry Medical College. He received his BSc and MSc degrees from the Biochemistry Department of
the University of Ibadan, Nigeria and his PhD degree in Molecular Biology from Humboldt-University
Berlin, Germany. Subsequently, he completed postdoctoral research training at Meharry Medical
College in the laboratory of Dr. Fernando Villalta. Dr. Nde’s overall research interest focuses on “host
pathogen interactions, molecular mechanisms of cardiac pathology induced by Trypanosoma cruzi
and diagnosis of neglected tropical diseases.” His current SC1 research project entitled “Molecular
mechanisms of Trypanosoma cruzi cardiopathogenesis ” is funded by NIAID,
http://projectreporter.nih.gov/project_info_description.cfm?aid=9073494. The focus of the grant is
to elucidate the molecular mechanisms utilized by T. cruzi to induce a fibrogenic response that can be
exploited for the development of molecular intervention strategies. He is also a previous recipient of
the SCORE SC2 grant from NIH. Currently, he is a member of ASBMB, American Society of Matrix
Biology and American Heart Association. Dr. Nde’s, publications are available in the link:
https://www.ncbi.nlm.nih.gov/sites/myncbi/pius.nde.1/bibliography/43068717/public/?sort=date&d
irection=ascending
Title of Dr. Nde’s RTRN Spotlight presentation is “Molecular mechanisms of cardiac fibrosis induced
by Trypanosoma cruzi infection”
Original Articles
1. Villalta, F., Dobish, M.C., Nde, P.N., Kleshchenko, Y.Y., Hargrove, T.Y., Johnson, C.A.,
Waterman, M.R., Johnston, J.N., and Lepesheva.G.I. VNI cures the acute and chronic
experimental Chagas disease. The Journal of Infectious Diseases. 2013; 208 (3):504-511.
Publications
1.
Udoko AN, Johnson CA, Dykan A, Rachakonda G, Villalta F, Mandape SN, Lima MF, PubMed
Pratap S, Nde PN. Early Regulation of Profibrotic Genes in Primary Human Cardiac
Myocytes by Trypanosoma cruzi. PLoS Negl Trop Dis. 2016 Jan; 10(1):e0003747.
2.
Lepesheva GI, Hargrove TY, Rachakonda G, Wawrzak Z, Pomel S, Cojean S, Nde PN, PubMed
Nes WD, Locuson CW, Calcutt MW, Waterman MR, Daniels JS, Loiseau PM, Villalta
F. VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas
Disease and Visceral Leishmaniasis. J Infect Dis. 2015 Nov 1; 212(9):1439-48.
3.
Farrow AL, Rachakonda G, Gu L, Krendelchtchikova V, Nde PN, Pratap S, Lima MF, PubMed
Villalta F, Matthews QL. Immunization with Hexon Modified Adenoviral Vectors
Integrated with gp83 Epitope Provides Protection against Trypanosoma cruzi
Infection. PLoS Negl Trop Dis. 2014 Aug; 8(8):e3089.
4.
Johnson CA, Rachakonda G, Kleshchenko YY, Nde PN, Madison MN, Pratap S, PubMed
Cardenas TC, Taylor C, Lima MF, Villalta F. Cellular response to Trypanosoma cruzi
infection induces secretion of defensin a-1, which damages the flagellum,
neutralizes trypanosome motility, and inhibits infection. Infect Immun. 2013 Nov;
81(11):4139-48.
5.
Villalta F, Dobish MC, Nde PN, Kleshchenko YY, Hargrove TY, Johnson CA, Waterman PubMed
MR, Johnston JN, Lepesheva GI. VNI cures acute and chronic experimental Chagas
disease. J Infect Dis. 2013 Aug 1; 208(3):504-11.
6.
Nde PN, Lima MF, Johnson CA, Pratap S, Villalta F. Regulation and use of the PubMed
extracellular matrix by Trypanosoma cruzi during early infection. Front Immunol.
2012; 3:337.
7.
Johnson CA, Kleshchenko YY, Ikejiani AO, Udoko AN, Cardenas TC, Pratap S, PubMed
Duquette MA, Lima MF, Lawler J, Villalta F, Nde PN. Thrombospondin-1 interacts
with Trypanosoma cruzi surface calreticulin to enhance cellular infection. PLoS One.
2012; 7(7):e40614.
8.
Nde PN, Johnson CA, Pratap S, Cardenas TC, Kleshchenko YY, Furtak VA, Simmons KJ, PubMed
Lima MF, Villalta F. Gene network analysis during early infection of human coronary
artery smooth muscle cells by Trypanosoma cruzi and Its gp83 ligand. Chem
Biodivers. 2010 May; 7(5):1051-64.
9.
Cardenas TC, Johnson CA, Pratap S, Nde PN, Furtak V, Kleshchenko YY, Lima MF, PubMed
Villalta F. REGULATION of the EXTRACELLULAR MATRIX INTERACTOME by
Trypanosoma cruzi. Open Parasitol J. 2010; 4:72-76.
10. Villalta F, Madison MN, Kleshchenko YY, Nde PN, Lima MF. Molecular analysis of PubMed
early host cell infection by Trypanosoma cruzi. Front Biosci. 2008; 13:3714-34.
11. Andrews JA, Bligh WJ, Chiodini PL, Bradley JE, Nde PN, Lucius R. The role of a PubMed
recombinant hybrid protein based ELISA for the serodiagnosis of Onchocerca
volvulus. J Clin Pathol. 2008 Mar; 61(3):347-51.
12. Madison MN, Kleshchenko YY, Nde PN, Simmons KJ, Lima MF, Villalta F. Human PubMed
defensin alpha-1 causes Trypanosoma cruzi membrane pore formation and induces
DNA fragmentation, which leads to trypanosome destruction. Infect Immun. 2007
Oct; 75(10):4780-91.
13. Augustine SA, Kleshchenko YY, Nde PN, Pratap S, Ager EA, Burns JM, Lima MF, PubMed
Villalta F. Molecular cloning of a Trypanosoma cruzi cell surface casein kinase II
substrate, Tc-1, involved in cellular infection. Infect Immun. 2006 Jul; 74(7):3922-9.
14. Simmons KJ, Nde PN, Kleshchenko YY, Lima MF, Villalta F. Stable RNA interference of PubMed
host thrombospondin-1 blocks Trypanosoma cruzi infection. FEBS Lett. 2006 Apr 17;
580(9):2365-70.
15. Nde PN, Simmons KJ, Kleshchenko YY, Pratap S, Lima MF, Villalta F. Silencing of the PubMed
laminin gamma-1 gene blocks Trypanosoma cruzi infection. Infect Immun. 2006
Mar; 74(3):1643-8.
16. Nde PN, Pogonka T, Bradley JE, Titanji VP, Lucius R. Sensitive and specific PubMed
serodiagnosis of onchocerciasis with recombinant hybrid proteins. Am J Trop Med
Hyg. 2002 May; 66(5):566-71.
17. Pogonka T, Brattig N, Nde PN, Adam R, Seeber F, Zipfel PF, Titanji VP, Lucius R. PubMed
Localization of T and B cell stimulating domains of the immunodominant 33-kDa
protein of Onchocerca volvulus (Ov33). Clin Immunol Immunopathol. 1997 Oct;
85(1):56-66.
18. Titanji VP, Nde PN, Ghogoinu SM, Tamo R, Lucius R, Perler F. The roles of IgG and PubMed
defined antigens in cytoadherence and cytotoxicity reactions to onchocercal
microfilariae. Afr J Health Sci. 1996 May; 3(2):33-6.
19. Zimmerman PA, Steiner LL, Titanji VP, Nde PN, Bradley JE, Pogonka T, Begovich AB. PubMed
Three new DPB1 alleles identified in a Bantu-speaking population from central
Cameroon. Tissue Antigens. 1996 Apr; 47(4):293-9.
20. Titanji VP, Nde PN, Mbacham WF. Cell-mediated and monoclonal antibody- PubMed
dependent killing of Onchocerca volvulus microfilariae. Scand J Immunol Suppl.
1992; 11:57-61.
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