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Endocrinology and human nutrition PROF. SILVIA DELLA CASA; PROF. GIACINTO ABELE DONATO MIGGIANO MODULE I Endocrinology (Prof. Silvia Della Casa) COURSE AIMS Learn the physiology and physiopathology of the various components of the endocrine system, with particular focus on the endocrine changes induced by physical and sporting activity. Clinical keynotes on the main endocrine diseases, with specific attention paid to the precautionary measures they require patients to take when conducting physical/sporting activities, or for which physical activity represents a fundamental preventive and / or therapeutic aid. The role of an improved lifestyle and regular physical activity as principal preventive and prophylactic factors against the more common, and ever more frequent, endocrinemetabolic diseases. The role of hormonal substances in the modification of physical/sporting performance and the risks correlated with their use and abuse (hormonal doping). COURSE CONTENT – – – – – – – – – – – – – – – – – – General principles of endocrinology. Hormonal secretion. Hormones and receptors. Hormonal modes of action. The functioning of the hypothalamus-pituitary axis. Regulation of hormone activity. Hypothalamic and pituitary hormones. Physiopathology of the hypothalamus-pituitary. Tumours of the hypothalamus-pituitary (pituitary adenomas, empty sella syndrome). Developmental alterations (dwarfism, acromegaly). Physiology and pathology of puberty. Hypopituitarism. Regulation of thirst and diuresis. Alterations in the posterior pituitary (diabetes insipidus). Physiology and physiopathology of the thyroid. Thyrotoxicosis. Hypothyroidism (congenital and acquired). Goitre and thyroid nodules. – – – – – – – – – – – – – – – – – – – – – – – – – – – – Tumours of the thyroid. Thyroiditis. Physiology and physiopathology of the adrenal glands. Hyperadrenalism (Cushing’s S., Conn’s S., pheochromocytoma). Hypoadrenalism (Addison’s S.). Cortisone therapy and sporting activity. Congenital adrenogenital syndromes. Physiology and physiopathology of calcium-phosphorus metabolism. Hypoparathyroidism. Hyperparathyroidism. Bone metabolism and factors influencing peak bone mass. Osteoporosis and the prophylactic effects of physical activity. Hypogonadism. Amenorrhea and amenorrhea in athletes. Hirsutism and virilism. Physiology and physiopathology of the pancreas. Pancreatic hormones (insulin and glycogen). Diabetes mellitus: classification and diagnosis. Insulin-dependent diabetes. Diabetes type II and insulin resistance. The treatment of diabetes mellitus and physical activity. The complications of diabetes. Hypoglycaemia. Obesity. Physical activity treatment of obesity. Forms of thinness; anorexia nervosa. Hormones and sports activity. Hormonal doping. READING LIST The texts to be used will be communicated at the first lecture. TEACHING METHOD Lectures. ASSESSMENT METHOD Computerised and timed multiple choice written exam. NOTES Further information can be found on the lecturer's webpage at http://docenti.unicatt.it/web/searchByName.do?language=ENG or on the Faculty notice board. MODULE II Human nutrition (Prof. Giacinto Abele Donato Miggiano) COURSE AIMS The course will teach the basics and applications of the Nutritional Sciences with regard to the use of nutrients and other bioactive substances by the human organism in relation to metabolic processes, growth, development and the organism’s functions, and to the individual’s state of health and well-being. The course – with the aim of improving quality of life and promoting good health - will also cover the more common nutritional problems and the specific nutritional neds linked to physical activity. In conclusion, the course will cover the dietary/nutritional intervention strategies indicated for normal subjects and/or specific conditions during sporting events (before, during and after the sporting event). COURSE CONTENT Human Nutrition (Basic and Applied) 1.1.1 Nutrients: the basis of life. 1.1.2 The significance of Eating, Nutrition and Dietetics. 1.2.1 The Concept of Balance. 1.2.2 The entry routes, depositary organs and excretory routes of nutrients. 1.3.1 Food Sources. The food groups and the composition of foods. 1.4.1 Nutritional elements and Energy Balance. Carbohydrates, lipids and proteins. 1.4.2 Metabolism of proteins, carbohydrates and lipids (keynotes). Metabolic adaptation to fasting. 1.4.3 Ethanol: from metabolite to toxin. 1.5.1 Water-salt metabolism (sodium, potassium, chloride). 1.5.2 Macro-minerals (calcium, phosphorous, magnesium, sulphur). Function and metabolism. 1.5.3 Micro-minerals (iron, copper, zinc, iodine). Oligominerals (selenium). Function and metabolism. 1.6.1 Water-soluble Vitamins (B Complex: B1, B2, B3, B5, B8, B9 or Folic Acid, B12, Vitamin C). 1.6.2 Fat-soluble Vitamins (Vitamins A, D, E, K). Structure, function and metabolism. 1.6.3 Vitamin F (Essential Fatty Acids: Linoleic acid, Linolenic acid, Arachidonic acid). Eicosanoids. Health Nutrition 2.1.1 Nutritional products and Health. 2.1.2 Nutritional medicines: molecules necessary for living. 2.1.3 Food drugs or Functional foods: useful for promoting good health. 2.2.1 Safe eating and Eating safety. 2.3.1 Epidemiology of nutritional diseases in Italy and the World. 2.4.1 Calorie and protein-calorie malnutrition. Obesity. The world of the weightloss diets. Sports Nutrition 1.1.1 Nutrients: at the basis of all physical activity. 1.2.1 Energy for Physical Activity. Measures of Energy Metabolism. Energy cost of Exercise. 1.3.1 The Body’s Composition (definition and methods of determination). 1.3.2 The Body’s Composition and Health: Correct Eating and Regular Physical Activity. 1.4.1 Nutritional Strategies for Sporting Events (before – during – after any physical performance/training). 1.4.2 Eating Strategies for regaining a correct body composition. 1.4.3 Nutritional Dietary Strategies for specific conditions (hormonal alterations, menopause, vegetarianism). READING LIST E.E. ZIEGLER-L.J. FILTER, Conoscenze attuali in Nutrizione, Piccin Nuova Libraria, Padua, 2002. E. CARNOVALE-L. MARLETTA, Tabelle di composizione degli Alimenti, National Institute of Research for Food and Nutrition (INRAN), Rome. Livelli di Assunzione Raccomandata di Energia e Nutrienti per la Popolazione Italiana (LARN) – Revised 1996, Italian Society for Nutrition. G. MIGGIANO, Nutrizione umana - Quiz di autovalutazione, Universo Publishing Society, Rome, 2002. G. MIGGIANO, La Nutrizione nello Sport - Aspetti nutrizionali dell’attività motorie, Universo Publishing Society, Rome, 2009 (at printers). G. ARIENTI, Le basi Molecolari della Nutrizione, Piccin Nuova Libraria, Padua, 1996. TEACHING METHOD Lectures (with lecturer in person and/or via teleconference). ASSESSMENT METHOD To ascertain the candidate’s preparedness for passing, they will be subjected to a multiple-choice exam covering material taken from the course content. The examination may involve, if necessary, one or more written tests or an oral exam in addition to or instead of the multiple choice exam. To pass, the student must satisfy all official requirements. NOTES Further information can be found on the lecturer's webpage at http://docenti.unicatt.it/web/searchByName.do?language=ENG or on the Faculty notice board.