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.- Biochemistry PROF. MARCO TREVISAN COURSE AIMS Students will acquire a theoretical grounding in the principal biochemical processes, both catabolic and energetic, of higher organisms. Special emphasis will be placed on the biochemical aspects related to nutrition. COURSE CONTENT CFU Biochemical transformations Introduction to the course. Fundamentals of biochemistry. Overview of biology, chemistry, physics and genetics. Enzymatic catalysis; reactions catalyzed by enzymes: thermodynamics, kinetics and regulation at the substrate level and biosynthesis. Integration of metabolic networks (metabolic compartmentalization; role of ATP, NAD(P)H, concept of cycle and metabolic pathway). Biological membranes and solute transport: thermodynamics, kinetics and specificity of transport. Communication within the organism. Metabolism. 1 Carbohydrate metabolism Carbohydrates: overview, classification, properties (principal monosaccharides, polysaccharides, plant cell wall). Glycolysis and its regulation. Aerobic and anaerobic conversion of pyruvate. Pentose phosphate pathway. Krebs cycle. Mitochondrial electron transfer and oxidative phosphorylation and coupling. 1 Carbohydrate metabolism Digestion and absorption of carbohydrates; glycaemia. Gluconeogenesis. Overview of photosynthesis CO2 fixation, Calvin cycle Nitrogen metabolism 0.5 Amino acids: overview, classification, properties. Proteins. Structure and function of proteins. Digestion and absorption of proteins. Metabolism of amino acids. Catabolism of amino acides, urea cycle. Energy metabolism. Cori cycle. Glucosealanine cycle. 1.5 Lipid metabolism Lipids: overview, classification, properties. Complex lipids. Digestion and absorption and utilization of lipids. Ketone bodies. Catabolism and biosynthesis of fatty acids. Regulation of lipid metabolism. Metabolism of cholesterol, phospholipids and glycolipids. Plasma lipoproteins. 1 Gene information and expression Biosynthesis and catabolism of nitrogenous bases. Nucleotides. Structure of DNA and variability of gene information. Replication and transcription of DNA. The genetic code. Characteristics and functions of RNA. Translation of mRNA. Polypeptide synthesis. 1 Esercitazioni 2 READING LIST NELSON D.L., COX M.M. Introduzione alla biochimica di Lehninger. 4° edizione, Zanichelli, Bologna, 2011 TYMOCZKO J.L, BERG J.M., STRYER L. Principi di Biochimica, Zanichelli, Bologna, 2010. CAMPBELL M.K., FARRELL S.O. Biochimica, terza edizione. Edises, Napoli, 2009. BERG J.M., TYMOCZKO J.L., STRYER L. Biochimica, sesta edizione. Zanichelli, Bologna, 2008. VOET D., VOET J.G., PRATT C.W. Fondamenti di biochimica, seconda edizione. Zanichelli, Bologna, 2007. L.SCARPONI (COORDINATORE) Biochimica Agraria - Pàtron Editore, Bologna, 2003. TEACHING METHOD Lectures, tutorials in the laboratory and classroom, for a total of 2 credits. ASSESSMENT METHOD There will be written and oral examinations. NOTES Attendance at the classroom and laboratory tutorials is strongly recommended. STUDENT RECEPTION HOURS Prof. Trevisan is available to meet with students after class in his office at the Institute of Agricultural Environmental Chemistry.