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Wolfgang Sadee Wolfgang Sadee, Dr.rer.nat. Felts Mercer Professor of Medicine and Chair, Pharmacology Director, Center for Pharmacogenomics The Ohio State University Columbus OH 43210-1239 [email protected] 614-292 5593 fax 614 292 7232 Group name: Center for Pharmacogenomics The OSU College of Medicine Center for Pharmacogenomics focuses on the discovery of genetic variants that serve as biomarkers guiding successful drug therapy in individual patients. The Center has developed new approaches for the discovery of genetic variants, with focus on gene regulation, including innovative genome-scale technologies such as massively-parallel sequencing and large-scale data integration (Genomics Core Laboratory and Bioinformatics and Statistics Core). A mathematical biology modeling group exploits large databases (ENCODE, GWAS, GTEx, and more) to define gene/RNA/protein networks relevant to disease risk and therapy for the design of biomarker panels, and subsequent testing of clinical utility in guiding individualized therapies. Members for ESPT Seweryn, Michal T. [[email protected]] [email protected] Danxin Wang [[email protected]] Samuel Handelman [[email protected]]