Wolfgang Sadee Group name: Center for Pharmacogenomics The
... genetic variants that serve as biomarkers guiding successful drug therapy in individual patients.
The Center has developed new approaches for the discovery of genetic variants, with focus on
gene regulation, including innovative genome-scale technologies such as massively-parallel
sequencing and lar ...
GUEST SPEAKER, Dr Sarah Elsea, Baylor College of Medicine and
... testing of hundreds of metabolites in a single biological specimen. Using a state-of-theart mass spectrometry platform, the resulting spectra are compared against a library of
~2,500 human metabolites. On average, ~800 small molecules are detected in a given
plasma sample with a core group of ~350 a ...
Small-Molecule Detection and Enantiopurity Measurement using
... properties for applications in biosensing and bioimaging. One area of our
research involves using DNA aptamers as recognition elements for the
development of new small-molecule detection and characterization assays. A
central goal in these experiments is to pursue novel analysis techniques that
... • National Cancer Institute
• GIST Cancer Research Fund
New Potential Lung Cancer Biomarkers Identified
... treated and untreated xenograft tumors (FFPE); also MSI analysis of frozen tumors allowed for detection of
the precision therapy drug, as well as lipids that were changing in expression as a result of treatment.”
A common problem in the treatment of cancer is that the tumors become resistant to the ...
Answer Key - Test Banks Shop
... D) daily quality control procedures
17. Which of the following items must be included in a laboratory safety manual?
A) continuing education requirements
B) reagent label requirements
C) employee records
D) proficiency testing requirements
18. The scope of practice for a clinical laboratory scientis ...
... DYX1C1 has three alternatively spliced transcripts. So we expect that alternative transcripts of DYX1C1 are used as a biomarker to detect specific
cancer. RT-PCR analysis is conducted in order to detect expression of the DYX1C1 gene and the PCR products were analyzed using the Image J
program to com ...
... region of non-coding DNA;
B. one that changes the third letter;
C. one that deletes one base in the
middle of a gene?
Check with your neighbors
The Development of a Method for the Characterization Of
... utilized for recreation and as sources of drinking water. The
ability to identify the source of microbial pollution,
Microbial source tracking (MST), is essential to any efforts
directed toward eliminating NPS pollution. Although
Coliform bacteria are commonly recognized indicators of
fecal contamin ...
Chow, Lu-Ping 周綠蘋 - 臺大基因體醫學研究中心
... Furthermore, the facility offers consultation
and support for protein separation techniques,
proteome -related bioinformatics and data
management. Our ongoing projects are
designed to identify all the components of
cancer and infectious disease proteomes,
providing a basis for functional studies. We ...
... environmental monitoring…
Cell-based Sensors; functional sensors, drug testing…
Point-of-care sensors; blood, urine, electrolytes, gases, steroids,
drugs, hormones, proteins, other…
Bacteria Sensors; (E-coli, streptococcus, other): food industry,
medicine, environmental, other.
Enzyme sensor ...
medical technology innovators: sienna cancer diagnostics
... who will perform the test, and clinicians who will analyse and use the test. Royal Melbourne Hospital,
Peter MacCallum Cancer Centre and Western Health were instrumental in Sienna's development of a
clinically useful test. These partners sourced clinical sample materials, and provided Sienna with cl ...
Past Research: Speech disorders in Down Syndrome
... • 28 LOPD subjects: RMT (n=14) vs. sham-RMT
– Optimal outcome measures to capture functional benefits
associated with RMT-induced respiratory strength
– Feasibility/utility of sham-RMT as a control condition for
... [ref 1] Nakamura S, Sato H, Tanaka R, Yaguchi T: Verification of Ribosomal Proteins of Aspergillus fumigatus for
use as Biomarkers in MALDI-TOF MS identification. Mass Spectrometry (Tokyo) 2016, 5:A0049.
[ref 2] Varshavsky A: The N-end rule: Functions, mysteries, uses. Proc. Natl. Acad. Sci. USA, 19 ...
MOLECULAR STUDIES OF Trypanossoma cruzi ISOLATED
... support diagnosis. Methodology: With the approval of Ethic Council – CEP/UERN, the
chagasic patients from this region will be included and subject to peripheral blood
collection to extract parasitic DNA and molecular identification of the T. cruzi strain. This
strains will be classified in DTU’s (di ...
Novel Biomarkers of Acute Kidney Injury Neutrophil Gelatinase
... • Biomarkers such as urinary IL-18, urinary albumin-to-creatinine ratio
(ACR), and urinary and plasma NGAL were demonstrated to improve
risk classification compared with the clinical model alone
• plasma NGAL performing the best
• biomarkers measured on the day of AKI diagnosis improve risk
Key Genes Associated with Cancer Found in Circulating Blood
... New York, NY; Munich, Germany; February 3rd, 2011 – Exosome Diagnostics Inc. a developer of body
fluid molecular diagnostics today announced that a team led by Dr. Johan Skog has published new
findings showing that microvesicles shed in circulation contain powerful genetic elements, called
Journal of Clinical Bioinformatics
... In metabolomics the bioinformatics-driven search for highly-discriminatory biomarker candidates has become
a key task in the biomarker discovery process with the objective of introducing novel biomarkers aiding in
diagnosis or therapeutic management [1–4].
A wide spectrum of feature selection method ...
... Supplementary Figure 4: A sub-network that illustrates the effect of Methylmalonate
semialdehyde dehydrogenase deficiency (OMIM 603178) on the metabolism and
transport of valine (val), beta-alanine (ala_B), 3-hydroxypropionic acid (3hpp), 3aminoisobutyric acid (3aib) and 3-hydroxyisobutyric acid (3 ...
In medicine, a biomarker is a measurable indicator of the severity or presence of some disease state. More generally a biomarker is anything that can be used as an indicator of a particular disease state or some other physiological state of an organism.A biomarker can be a substance that is introduced into an organism as a means to examine organ function or other aspects of health. For example, rubidium chloride is used in isotopic labeling to evaluate perfusion of heart muscle. It can also be a substance whose detection indicates a particular disease state, for example, the presence of an antibody may indicate an infection. More specifically, a biomarker indicates a change in expression or state of a protein that correlates with the risk or progression of a disease, or with the susceptibility of the disease to a given treatment. Biomarkers can be characteristic biological properties or molecules that can be detected and measured in parts of the body like the blood or tissue. They may indicate either normal or diseased processes in the body. Biomarkers can be specific cells, molecules, or genes, gene products, enzymes, or hormones. Complex organ functions or general characteristic changes in biological structures can also serve as biomarkers. Although the term biomarker is relatively new, biomarkers have been used in pre-clinical research and clinical diagnosis for a considerable time. For example, body temperature is a well-known biomarker for fever. Blood pressure is used to determine the risk of stroke. It is also widely known that cholesterol values are a biomarker and risk indicator for coronary and vascular disease, and that C-reactive protein (CRP) is a marker for inflammation.Biomarkers are useful in a number of ways, including measuring the progress of disease, evaluating the most effective therapeutic regimes for a particular cancer type, and establishing long-term susceptibility to cancer or its recurrence. The parameter can be chemical, physical or biological. In molecular terms biomarker is ""the subset of markers that might be discovered using genomics, proteomics technologies or imaging technologies. Biomarkers play major roles in medicinal biology. Biomarkers help in early diagnosis, disease prevention, drug target identification, drug response etc. Several biomarkers have been identified for many diseases such as serum LDL for cholesterol, blood pressure, and P53 gene and MMPs as tumor markers for cancer.