- Journal of Hepatology
... indication of an increased turnover of phosphatidylcholine and
phosphatidylethanolamine species in the liver, thus releasing free
fatty acids through the action of phospholipases A1 and A2. These
fatty acids, if not catabolized by b-oxidation, will be stored in the
liver as triacylglycerols. This is ...
1 A multi-platform metabolomics approach identifies novel
... In total we identified 49 metabolites that were significantly different between BV and N
(unpaired t-test, Benjamini-Hochberg p < 0.01, Table S2). Nineteen of these have not
been reported as differential in the literature, and 12 could not be identified. We
determined the odds ratio (OR) for BV base ...
Chapter 1 - Research Explorer
... treatment interventions. Treatment is in general aimed to reduce metabolic
decompensation as well as to prevent neurological damage and developmental delay.
The phenotypical presentation of the organic acidemias is broad.
Isovaleric acidemia (IVA), which is the result of the defective isovaleryl-CoA ...
Organic biomarkers in deep-sea regions affected
... and neutral amino acids are less labile than pigments and unsaturated fatty acids, but like them, they are utilized as indicators of labile material (Mayer et al., 1995; Lee et al., 2004).
The use of this combination of biomarkers will allow for us
to study the effects of sediment reworking by trawl ...
Circulating Folate, Vitamin B12, Homocysteine, Vitamin B12
... hence, it was adjusted for exact age and the study center
where the recruiting general practice was based (ninelevel variable). Pairwise correlations between circulating
vitamin and metabolite concentrations (and with PSA
level) in controls were measured by Spearman's rank correlation coefficient. G ...
Download: 7.2 MB PDF
... pioneering a systems approach that supports healthcare providers in the personalized
treatment and prevention of chronic disease.
Chronic diseases are often complex and Genova’s system-based testing helps physicians
develop targeted treatments for their patients. Easy-to-read color graphic reports s ...
... • Clinical use of biomarkers for early diagnosis
of AKI is promising but awaits prospective
clinical trials .
• While several trials have demonstrated the
ability to reduce AKI in randomized trials only
hANP has demonstrated ability to reduce AKI
and decrease risk of CKD and Dialysis
Secrets from the microbiome: molecular biology meets microbiology
... Secrets from the microbiome: molecular biology meets microbiology meets
histopathology….meets clinical biochemistry
The microbiome is the collective term used to describe the bacteria, viruses, fungi and archaea that
reside on and in the human body. The majority of these organisms are found ...
Chronic Liver Diseases
... coronary syndromes, can produce chest pain
at rest, lead to specific changes in tile
electrocardiogram, and a mild or severe
release of enzymes and proteins into blood.
Observations on the role of nuclear medicine in molecular imaging
... glucose metabolism. One PET agent is 11Cpalmitate which behaves identically to natural
fatty acids in uptake and metabolism in the
myocardium. Fatty acids may also be labeled
with 123I and used for the same purpose but with
SPECT. One such agent is labeled iodophenypentadecanoic acid (i.e., 123I-IPP ...
Increased Protein and Lipid Oxidative Damage in
... and neuroprostanes in plasma; however, data presented
in this study showed increased levels of protein-bound
HNE in the mitochondria isolated from lymphocyte of
AD and shows a trend toward negative correlation to
the MMSE score, consistent with our findings reported
in the present study. In the plas ...
Apresentação do PowerPoint
... -Detection of small increases in oxidant/radical production
improved probes/spin traps under development (this symposium)
-Monitoring GSSG/2 GSH levels (Schafer & Beuttner FRBM 30, 1191)
may not reflect localized redox unbalance (Go et al. JBC 279, 5837)
-Characterizing/quantifying products/radicals ...
Markers of renal function tests (PDF Available)
... the routine methods gave borderline values for the index
of proteinuria . During pregnancy proteinuria assay in
24 hour urine sample is performed. One of the
investigations for proteinuria is semi-quantitative dipstick
urinalysis as this method is relatively low cost and easily
... Identification of disease type by discovery of
disease-related genes and analysis of profiles.
Support for deciding on an optimum
therapeutic policy in combination with clinical
information. For infectious diseases, diagnosis
of the presence or absence of infection by
Ingenuity Pathway Analysis of metabolomics data including cross
... diabetic mouse, one of the most extensively studied animal models of severe type 2 diabetes. To assist with cross
platform integration we have used IPA-Metabolomics™ analysis. IPA-Metabolomics is powered by the Ingenuity
Knowledge Base, a repository of molecular interactions, regulatory events, sign ...
Systems Biology Investigation to Discover Metabolic Biomarkers of
... Background: Drug-induced hepatotoxicity is one of the major reasons for drug recall and hence it is of major
concern to the FDA and consumers. Overdose of acetaminophen (APAP) can cause acute hepatic injury. The
current clinical biomarkers of liver injury are insufficient in predicting the extent of ...
Spain - Eurocare
... The preliminary results of our study evidence for first time the presence of EtG and EtS in
meconium. Further investigations are ongoing to verify the use of these two ethanol metabolites
as alternative biomarkers of chronic in utero exposure to alcohol.
Metabolomic Profiling Identifies Biomarkers Associated
... Use these new assays in a representative cohort not used to
identify the candidate biomarkers to test their suitability:
– To predict incident type 2 diabetes alone
– For use in models with other metabolites and metabolic
l The prediction of type 2 diabetes
l Monitoring interventi ...
Comparative Study of Serum lactic Acid, Lactate
... It has been rep orted that LDH activity is inhibited in the postischemic myocardium, which is
associated with p oor glucose oxidation and impaired my ocardial p erformance .
A st udy conducted on rat reported that a three fold increase in LDH content in rat heart
comp ared with liver, the author ...
... F-FDOPA may perform particularly well in patients with PGL who do not carry a SDHB
mutation (17). (However, in pts with metastatic pheochromocytoma or PGL, 18F-FDG or 18FFluorodopamine may perform better than FDOPA (17, 18)).
In patients with MTC and elevated calcitonin levels, 18F-FDOPA PET/CT may ...
DOC - Investor Relations
... patients with multi-vessel disease. It is important to note that, with a 110 minute half-life, flurpiridaz F 18 can be used in conjunction
with treadmill exercise, which is not feasible with other currently available PET tracers for MPI.
About PET and MPI
PET imaging or a PET scan is a type of nucle ...
In medicine, a biomarker is a measurable indicator of the severity or presence of some disease state. More generally a biomarker is anything that can be used as an indicator of a particular disease state or some other physiological state of an organism.A biomarker can be a substance that is introduced into an organism as a means to examine organ function or other aspects of health. For example, rubidium chloride is used in isotopic labeling to evaluate perfusion of heart muscle. It can also be a substance whose detection indicates a particular disease state, for example, the presence of an antibody may indicate an infection. More specifically, a biomarker indicates a change in expression or state of a protein that correlates with the risk or progression of a disease, or with the susceptibility of the disease to a given treatment. Biomarkers can be characteristic biological properties or molecules that can be detected and measured in parts of the body like the blood or tissue. They may indicate either normal or diseased processes in the body. Biomarkers can be specific cells, molecules, or genes, gene products, enzymes, or hormones. Complex organ functions or general characteristic changes in biological structures can also serve as biomarkers. Although the term biomarker is relatively new, biomarkers have been used in pre-clinical research and clinical diagnosis for a considerable time. For example, body temperature is a well-known biomarker for fever. Blood pressure is used to determine the risk of stroke. It is also widely known that cholesterol values are a biomarker and risk indicator for coronary and vascular disease, and that C-reactive protein (CRP) is a marker for inflammation.Biomarkers are useful in a number of ways, including measuring the progress of disease, evaluating the most effective therapeutic regimes for a particular cancer type, and establishing long-term susceptibility to cancer or its recurrence. The parameter can be chemical, physical or biological. In molecular terms biomarker is ""the subset of markers that might be discovered using genomics, proteomics technologies or imaging technologies. Biomarkers play major roles in medicinal biology. Biomarkers help in early diagnosis, disease prevention, drug target identification, drug response etc. Several biomarkers have been identified for many diseases such as serum LDL for cholesterol, blood pressure, and P53 gene and MMPs as tumor markers for cancer.