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MAKING A DIFFERENCE FOR CHILDREN Academic Annual Review 20082009 Department of Pediatrics University of Arkansas for Medical Sciences Arkansas Children’s Hospital Chairman’s Letter Dear Colleague: Academic year 2008‐2009 was exciting and successful for the University of Arkansas for Medical Sciences Department of Pediatrics. The key element that has been nurtured and continues to grow is our partnerships. New faculty recruitment, new clinical programs, expanded educational programs, new and larger NIH research grant awards and expanding faculty development programs have all contributed to these successes. New collaborative partnerships with Arkansas Children’s Hospital to enhance efficiencies through the Outpatient Initiative, the Patient Flow program and Disaster Preparedness have shown tremendous potential. The growth of our quality improvement programs has led to marked improvements in patient care and safety. The future of scholarly activity in these arenas is exciting. The collaborative partnerships with the Arkansas Children’s Hospital Research Institute has led to major infrastructure advances that will give researchers back “time” that they need and cherish. New initiatives between the DOP and ACHRI for recruitment in childhood obesity, cardiac genetics/genomics, and autism will be underway in FY10 capitalizing on new research space and joint resources. The announcement that the University of Arkansas for Medical Sciences was awarded a CTSA grant in FY09 is a significant opportunity for collaboration between Department of Pediatrics programs and the University of Arkansas for Medical Sciences CCTR. The environment of “partnerships” has led to new working relationships that show great promise for the future. These and many more goals and dreams are now outlined in the Department of Pediatrics White Papers, published in July of 2009. The White Papers, developed as a result of the Department of Pediatrics Leadership Retreat in 2008, provides a current assessment of and three to five‐year goals for the four main missions of the Department of Pediatrics: clinical care, education, research and service. Sincerely, Richard F. Jacobs, MD, FAAP Robert H. Fiser, Jr., MD, Endowed Chair in Pediatrics Professor and Chairman, Department of Pediatrics University of Arkansas for Medical Sciences President, Arkansas Children's Hospital Research Institute Pediatric Infectious Diseases Arkansas Children's Hospital Page | 1 UAMS Pediatrics The Department of Pediatrics at the University of Arkansas for Medical Sciences provides exceptional patient care, education and research. Our mission is to spread and promote medical knowledge appropriate to the future of the field of pediatrics through a balanced emphasis on education, research, and health care. Through our partnership with Arkansas Children's Hospital, our services include pediatric training, clinical assessment, diagnosis and treatment of acute and chronic disorders, and cutting‐edge research on techniques to enhance a child’s home and medical environment. The Department of Pediatrics is the largest department of the University of Arkansas for Medical Services (UAMS) College of Medicine with geographic bases on the Arkansas Children’s Hospital (ACH) campus, at University Hospital on the UAMS Campus and with programs and clinics located in 16 other communities in Arkansas. The department includes over 220 faculty members representing physicians in general pediatrics and over 20 pediatric subspecialty areas, psychologists and PhD research faculty, plus over 1,000 support staff. Arkansas Children’s Hospital is the only pediatric medical center in Arkansas and one of the largest in the United States serving kids from birth to age 21. The ACH pediatric health care facility boasts an internationally renowned reputation for medical breakthroughs and intensive treatments, unique surgical procedures and forward‐ thinking medical research – all dedicated to enhancing, sustaining and restoring children’s health and development. www.arpediatrics.org UAMS Pediatrics Page | 2 University of Arkansas for Medical Sciences (UAMS) The UAMS College of Medicine is Arkansas’ only medical school and one of six academic units of UAMS, the state’s principal biomedical research center. UAMS has outstanding faculty on staff at UAMS Medical Center, Arkansas Children’s Hospital, the McClellan Veterans Administration Hospital, the Central Arkansas Radiation Therapy Institute and Area Health Education Centers throughout the state. UAMS strives to help tomorrow’s physicians acquire not only the ultimate in medical skills, but also professional and ethical standards that will aid them in their careers and ensure the very best care for patients. www.uamshealth.com Our Partners Page | 3 Arkansas Children’s Hospital (ACH) Arkansas Children's Hospital is the only pediatric medical center in Arkansas and one of the largest in the United States serving kids from birth to age 21. The ACH pediatric health care facility boasts an internationally renowned reputation for medical breakthroughs and intensive treatments, unique surgical procedures and forward‐ thinking medical research ‐ all dedicated to fulfilling our mission of enhancing, sustaining and restoring children's health and development. Arkansas Children's Hospital provides innovative care for patients and families in the fields of childhood cancer, pediatric cardiology, neonatology, pediatric orthopedics, vascular anomalies and more. The physicians, nurses and staff of Arkansas Children's Hospital are committed to providing care, love and hope to the children of Arkansas and the world. Our Partners www.archildrens.org Page | 4 Arkansas Children’s Hospital Research Institute (ACHRI) Advances in pediatric medicine begin with a vision for a future in which all children can grow up to be healthy adults. Arkansas Children's Hospital Research Institute researchers share this common vision and have devoted their lives to making this vision a reality. At ACHRI, children are at the center of everything that we do. Researchers at ACHRI are addressing a broad spectrum of children’s health concerns, such as the biological mechanisms underlying birth defects; diabetes‐related complications; and numerous childhood diseases, including asthma and cancer. Research expertise is diverse, ranging from basic science to clinical and community‐ based research. Researchers are improving the health of children, families, and their communities through clinical, basic science, health promotion, health outcomes, health services, and prevention research. ACHRI was established in 1989 to provide a biomedical research environment for the University of Arkansas for Medical Sciences (UAMS) faculty conducting research on the Arkansas Children’s Hospital campus. A majority of ACHRI’s research community are faculty of the UAMS College of Medicine Department of Pediatrics. ACHRI is a not‐for‐ profit corporation owned by ACH. Our Partners http://achri.archildrens.org Page | 5 Clinical Service Clinical Service The Department of Pediatrics offers a wide range of pediatric medicine programs at Arkansas Children’s Hospital and staffs the nurseries of the University Hospital, caring for more than 7,117 inpatient discharges and over 1,100 newborns in FY 08‐09. The Department of Pediatrics works closely with Arkansas Children’s Hospital in providing clinical staff and medical direction to several cross‐disciplinary specialty services including Transplant Services and critical care, level 3‐4, services. The Cardiology heart transplant program continues to be one of the busiest pediatric transplant programs in the country with 25 transplants in FY 08‐09, a 38.8% increase over last year. An air medical critical care transport service at Arkansas Children’s Hospital is staffed by the Pediatrics faculty and the service transported approximately 2,100 patients this year. FY 08‐09 included the move by the Section of Neonatology to the new University Hospital Neonatal Intensive Care Unit (NICU) with 65 private rooms, each with accommodations for parents. This has resulted in a greater emphasis on family centered care and enhanced parental satisfaction. Coupled with the 85 bed NICU at ACH, the total of 150 available NICU beds makes the UAMS Neonatal‐Perinatal training program the largest in the United States. The State Outreach/Education Program has been greatly enhanced through a novel telemedicine program which allows immediate visual communication from UAMS and ACH NICU’s to 24 nurseries across Arkansas. These nurseries care for most deliveries in the state outside the Little Rock area. Since the establishment of this program, the state’s neonatal and infant mortality rates have decreased, attesting to the importance of outreach efforts. Physicians from the department staff outpatient clinics operated by Arkansas Children’s Hospital on the main campus and in west Little Rock. Outpatient visits for these clinics in FY 08‐09 totaled over 175,000, an increase of 4.5% over last year. Additionally, the department operates clinics located in the Dennis Development Center in Little Rock, the Center for Children in Lowell and regional outreach clinics in 16 subspecialties in more than 16 locations around Arkansas. Patient visits in these clinics total over 17,000. Page | 6 Clinical Services On July 1, 2008, the advanced newborn screening program began in Arkansas which expanded existing screening to include 29 rare conditions that can be harmful ‐ even fatal – to newborns. This major undertaking has happened smoothly with major collaborations between the Section of Genetics and Metabolism, ACH labs and the Arkansas Department of Health. The program has been a huge success in identifying children with life‐threatening disorders prior to onset of illness. The Department also supports KIDS FIRST, a multidisciplinary diagnostic and day treatment service for between 600 and 700 medically and developmentally at‐risk preschoolers in 11 community‐based centers distributed widely around Arkansas. In an effort to expand access to its specialized care to the rural areas, some specialties are also providing telemedicine services. The Department of Pediatrics provides medical direction for and administers the Head Start and Early Head Start programs in Pulaski County. Roughly 10 percent of the more than 10,000 Head Start children in Arkansas are in the UAMS‐administered programs. The children receive education, health screenings and evaluations, direct health care and are included in model health programs. Page | 7 Education Education Education is an integral part of the mission promoted by the Department of Pediatrics. The department participates in medical student education in the pre‐clinical and clinical years of medical school. The department sponsors a summer science program for college students, designed to offer sophomore through senior level students interested in medical careers the opportunity to work in a research setting for ten weeks during the summer. The Department of Pediatrics provides residency training for over 80 trainees each year in Pediatric programs. Approximately half of these trainees are Arkansas natives and the other half are recruited from out‐of‐state. The department also operates fellowship training programs in 12 subspecialties. The educational infrastructure was enhanced this year with the opening of a new classroom, equipped for tele‐education, distance learning and archiving. The classroom has expanded capabilities for student, resident, fellow and faculty education as well as position the department to provide collaborative education to the new UAMS Northwest Arkansas medical school campus. The Peds PLACE (Physician Learning and Collaborative Education) is a teleconference focusing on a new pediatric or neonatal problem each week. Enable through teleconferencing technology, Peds PLACE invites pediatric providers of the University of Arkansas for Medical Sciences, Arkansas Children’s Hospital and hospitals across the state to explore themes in pediatric medicine. Peds PLACE is available over the internet with archived conferences available for viewing after the broadcast. The PULSE Center continues to be a cutting edge facility in which student, resident, and fellow educational modules continue to be developed and taught with the assistance of the PULSE Center team. Page | 8 The general pediatric inpatient service conducts family‐centered rounds at the bedside. These bedside work rounds offer a unique opportunity for medical students and residents to refine examination and communication skills with attending physician feedback. While providing patient‐centered care, trainees benefit from the active participation of families in the rounding process. Faculty and staff of the department provide a variety of continuing education offerings for Arkansas health professionals including Grand Rounds, research conferences, journal club and pediatric seminars. Endowed lectureships help bring renowned educators and researchers to campus. Education Page | 9 Research Research Research continues to flourish for the Department of Pediatrics faculty. Researchers in the department had a total of 273 projects active during FY 08‐09. In a national downward trend in NIH funding, the department had a very successful year. FY 08‐09 saw a 21% increase in NIH funding over last year and set a new record level of NIH funding in the department’s history. From this research, faculty were busy in the area of publications, with 220 journal articles and 61 books or book chapters published in FY 08‐09. Page | 10 Administration The Department of Pediatrics is administered by Richard F. Jacobs, M.D., FAAP, Robert H. Fiser, Jr., M.D. Professor and Chairman. The Chairman is assisted by four Vice Chairs M. Michele Moss, M.D., Vice Chair for Clinical Services Christopher E. Smith, M.D., Vice Chair for Education John L. Fowlkes, M.D., Vice Chair for Research Patrick H. Casey, M.D., Vice Chair for Faculty Affairs The department is composed or research and clinical programs and academic sections. Faculty Affairs Administration The Department of Pediatrics has an outstanding Faculty Affairs program which provides formal mentoring committees for all young faculty. The department promotion and tenure committee tracks all new faculty upon arrival to the campus. Faculty Development programs are gaining in substance and impact. There are currently 64 faculty members with active mentoring committees. Over the last year, nine new committees were formed as new faculty members joined the department and six committees were retired due to the success of the committee when those faculty members were promoted. As faculty members are promoted, they are transitioned from mentees into mentors, passing on knowledge and mentoring methods that were helpful to them during their early years in the department. The DOP continued to grow with faculty recruitment in FY 08‐09 adding 23 new faculty members. Three new Section Chiefs started in FY 08‐09, heading up the Biostatistics Program, Infectious Diseases section and Genetics and Metabolism section. Academic matriculation continues in FY 08‐09 with four faculty members promoted to Professor, four promoted to Associate Professor and five received tenure. Junior faculty continue to progress in their goals with six being promoted from Instructor to Assistant Professor. Page | 11 Learn More Learn More Learn more about Department of Pediatrics’ education, research and clinical programs by visiting www.arpediatrics.org/about‐us/annual‐report where you will find details on each academic division’s accomplishments. Adolescent Medicine Allergy and Immunology Biostatistics Program Birth Defects Research Cardiology Center for Applied Research and Evaluation (CARE) Children at Risk Community Pediatrics Critical Care Medicine Developmental Pediatrics Emergency Medicine Endocrinology and Diabetes Gastroenterology, Hepatology and Nutrition General Pediatrics Genetics and Metabolism Hematology and Oncology Infectious Diseases Neonatology Nephrology Neurology Pharmacology and Toxicology Psychology Pulmonology Rheumatology Schmieding Developmental Center Meet our Faculty The Department of Pediatrics University of Arkansas for Medical Sciences College of Medicine Arkansas Children’s Hospital 1 Children’s Way Little Rock, AR 72202 (501) 364‐1442 www.arpediatrics.org Page | 12 Annual Report: 2008•2009 Department of Pediatrics University of Arkansas for Medical Sciences College of Medicine ANNUAL REPORT: 2008‐2009 Executive Summary FY09 has been an exciting and successful year for the Department of Pediatrics (DOP). New faculty recruitment, new clinical programs, expanded educational programs, new and larger NIH research grant awards and expanding faculty development programs have all contributed to the success. New collaborative partnerships with Arkansas Children’s Hospital (ACH) to enhance efficiencies through the Outpatient Initiative (OPI) and the Patient Flow program have shown tremendous potential. The environment of “partnerships” has led to new working relationships that show great promise for the future. These and many more goals and dreams are now outlined in the DOP White Papers, published in July of 2009. The White Papers, developed as a result of the DOP Leadership Retreat in 2008, provides a current assessment of and three to five‐year goals for the four main missions of the DOP: clinical care, education, research and service. Education Annual Report: 2008‐2009 | UAMS Department of Pediatrics Student, Resident and Fellow Training 1 The Office of Education this year successfully compiled the 2009 Education White Paper establishing goals for the next five years. These goals include, among other things, a commitment to increased educational scholarship by clinical educators and educational leadership. To that end, the resignation of Tricia Edstrom to coordinate the curriculum for the NWA campus provided an opportunity to expand that position with the express purpose of improving the educational programs and increasing scholarship. Dr. Beatrice Boateng was hired as faculty into that role and has taken up the challenge set forth in the white paper. The educational infrastructure was also enhanced this year with the opening of a new classroom, equipped for tele‐education, distance learning and archiving. This classroom has expanded capabilities for student, resident, fellow, and faculty education as well as position the DOP to provide collaborative education to the NWA campus. The PULSE Center continues to be a cutting edge facility in which student, resident, and fellow educational modules continue to be developed and taught with the assistance of the PULSE Center team. Several IRB submissions have come from the collaborative work of the team and DOP faculty members and several manuscripts, workshops, and abstracts are expected this next year. In addition, the Educational Scholarship Working Group continues to play a role in the fostering of educational scholarship of DOP faculty. In addition to these programs, the ward teams were restructured into unit based assignments to help provide better education, interdisciplinary collaboration, continuity, and more family centered rounds. Much was learned from this transition and changes were made for this coming year to allow an even better attainment of these goals. These are just a few examples of the ongoing educational infrastructure to support, encourage, and reward excellence. In undergraduate education, the Department continues to fund the Summer Science program for students. Expanded partnership with ACH and ACHRI allowed sustained funding of an increased number of top student applicants, with Arkansas ties, in the area of science and pediatrics. During the preclinical years of medical training, Department faculty members provide leadership for the Intro to Clinical Medicine, Cell Biology, and Medical Genetics courses. DOP faculty continue to serve as preceptors in these courses as well as the ethics curriculum. The Pediatric Interest Group, with student leadership and faculty guidance, continues to attract interested students and foster recruitment into Pediatrics and Pediatric Subspecialties at an early point in the training process. Annual Report: 2008‐2009 | UAMS Department of Pediatrics Medical Student training this year began a transition in leadership from Dr. James Graham to Dr. Becky Latch. Dr. Latch will have an expanded role as Director of Students and will be assisted by Dr. Mary Huckabee, who will serve as Associate Director. In addition, a student advisory council was established to review and recommend changes to the junior clerkship. The goal for this next year is to improve performance on the USMLE exams. Enhanced and interactive lectures, better tracking of students by faculty mentors, and more robust testing and review sessions are planned to accomplish this task. Pediatric career choices continue to be popular this year as 17% of senior graduates have chosen residencies in Pediatrics and Medicine‐Pediatrics. 2 Residency training continues to seek innovative ways to attract top applicants and promote excellence. Sixty‐two percent of matched interns qualified for the Chairman Scholars Program this year, an all‐time record. The first time pass rate on boards was much improved this year at over 90%. Recommendations for improvement from a previous retreat were implemented to identify and target the “at risk” resident. This strategy includes a strict reading plan with accountability, a formal meeting with an expanded faculty group to help each resident assess their needs for board preparation, and a continued intensive board review in the last two months of the academic year. Staff time was added to the residency office this year to provide a more dedicated approach to alumni activities and tracking. From this effort, it is hopeful that regular surveys of alumni will continue to enhance the educational curriculum. Fellowship programs continued to expand this year with nearly 30 fellows now engaged at some level of training. Fellows continue to be successful in presenting at their respective regional and national meetings. The DOP continues to support 10 (including Child Neurology) fellowship programs and shared fellow education continues through a monthly core curriculum series. This year focused on practice based learning and improvement and scientific reading and writing. Fellow’s Day this year continued the trend of success with more presentations, inclusion of more non‐DOP fellows and a continued partnership with ACHRI and ACH in the planning and execution of this annual event. A subgroup of the Fellowship Program Directors has been formed and tasked with review of the feedback and make recommendations for next year’s Fellow’s Day. Ongoing professional education inside and outside the department is accomplished through a regular series of faculty development seminars, which were expanded this year, the annual Pediatric Summit which is planned in partnership with ACH and the Arkansas AAP Chapter. Peds PLACE, the weekly interactive conference that links department faculty with physicians in the state continued to be successfully and became a regular part of the weekly conference schedule with residents attending each week. Also, substantial, and hopefully, final preparation has been made to provide CME for archived conferences. Utilizing the equipment in the new 3rd Floor Classroom, lectures are archived and will soon be able to be viewed for CME credit. A good measure of our effectiveness in education is the number of faculty recognized as effective educators. This year Dr. Ritu Sachdeva was awarded the Betty Lowe Chair in Education to start in FY10. Dr. Christopher E. Smith, Vice‐Chair for Education, received the Master Teacher Award for FY09 from the UAMS College of Medicine, an annual award to recognize outstanding work in medical and resident education. Drs. Tad Fiser, Jill Fussell, Ritu Sachdeva and Kendall Stanford, were recipients of the DOP Educator of the Year Award for 2009. Established in 1997, the Educator of the Year Award recognizes outstanding educators in the DOP. Nineteen of our faculty were selected to received Red Sashes at graduation, which ties with the highest number of awardees from the Department in the past 10 years. FY09 has been very successful in the area of education. Of course, there are still opportunities to expand successes and strive for even greater excellence in the year ahead. These goals are outlined in the DOP White Papers. Faculty Affairs Annual Report: 2008‐2009 | UAMS Department of Pediatrics The DOP had much faculty activity in FY09, adding 22 new faculty members who started in early FY09. Three new Section Chiefs started in FY09; Dr. Todd Nick as Biostatistics Program Director, Dr. Jose Romero as Chief of Pediatric Infectious Diseases, and Dr. G. Bradley Schaefer as Chief of Genetics and Metabolism Section. Dr. Schaefer also serves as the founding director of the new Division of Genetics in the College of Medicine. Also during FY09, recruitment and hire of at least 15 new faculty members has been confirmed for FY10. 3 The faculty continues to matriculate academically. Effective July 1, 2009 four faculty members were promoted to Professor, four were promoted to Associate Professor and five received tenure. Junior faculty continue to progress in their goals with six being promoted from Instructor to Assistant Professor. The Faculty Council, chaired by Dr. Pat Casey, has met every other month this year. Council members include Drs. Kimo Stine, Joan Cranmer, Tad Fiser, Amy Scurlock, Chuck Lumpkin and Casey, with Dr. Chris Smith Ex‐Officio as Vice Chair for Education. The Council reviewed and discussed a variety of issues of importance to the general faculty, with recommendations to the Department Chair. The Council reviews the actions and makes suggestions to the Office of Faculty Promotion, Tenure and Mentoring, and the Office of Faculty Education and Development. The Council coordinated the decision to award Dr. Stacie Jones the DOP Mentor of the Year Award for FY09. This year the Council coordinated two Town Hall Fora with Dr. Richard Jacobs, DOP Chairman, and Dr. Bonnie Taylor, ACH Medical Director. Dr. Joan Cranmer, Director, Office of Faculty Promotion, Tenure and Mentoring, continues to initiate the formation of mentoring committees with new and junior faculty, recruits senior faculty members to become mentors and maintains the history of each current and retired mentoring committee. She oversees the processes and membership of the faculty mentoring committees and partners with Dr. Pat Casey to ensure that committees remain active and successful. This year, the Mentoring Program developed the Mentoring Committee Standard Operating Procedures which outline the guidelines for tenure and non‐tenure faculty mentoring committees. There are currently 64 faculty members with active mentoring committees. Over the last year, nine new committees were formed as new faculty members joined the Department and six committees were retired due to the success of the committee when those faculty members were promoted. As faculty members are promoted, they are transitioned from mentees into mentors, passing on the knowledge and mentoring methods that were helpful to them during their early years in the Department. Dr. Kimo Stine has expanded the DOP Office of Faculty Development, holding 18 Faculty Development seminars in FY09 with an average attendance of 18. This year seminars were available to fellows as well as all UAMS faculty members on the ACH/ACHRI campus. Dr. Stine and his staff successfully continue to maintain accreditation for CME for the seminars through the office of continuing education at UAMS. Annual Report: 2008‐2009 | UAMS Department of Pediatrics The DOP Office of Faculty Development applied for and received CME accreditation for the first Annual Faculty Development Conference, a one‐day event to be held at Arkansas Children’s Hospital (ACH) on September 8, 2009 titled “Writing for Success.” Several speakers have been invited and attendees will have a choice of which seminars to attend, with a total of six CME credits possible. The key‐note speaker will be Robert Arceci, MD, PhD, King Fahd Professor at Johns Hopkins Hospital. 4 Dr. Stine has also invited a number of his colleagues to form a panel, or committee, for the planning of future Faculty Development seminars and events. Hopefully, such a panel will bring together new ideas for seminars, as well as feedback on past events. While the panel is still in its early stages, its first round‐table discussion was held on July 21, 2009 mostly focusing on the goals of the Faculty Development seminars for the coming Fall and Spring. The panel discussed new seminar ideas, as well as who constitutes the ideal audience, what they would benefit most from and how to encourage attendance. Included in the DOP White Papers under the Service mission, Faculty Affairs and Faculty Development are highlighted with 3 to 5‐year goals for these vital programs. Clinical The clinical enterprise in the DOP has been marked by growth in virtually all areas. The DOP recorded 9,655 inpatient discharges in FY09, a minimal change from last year. The Cardiology heart transplant program continues to be one of the busiest pediatric transplant programs in the country with 25 transplants in FY09, a 38.8% increase over last year. The Cardiology Section has initiated a new statewide program in fetal cardiac diagnosis and management. The Fetal Heart Center will provide families and physicians a comprehensive program to diagnose and care for fetuses with cardiac conditions and to provide high level clinical care in addition to education, supportive services, and research opportunities. The goal is to directly impact morbidity and mortality of infants with heart disease in Arkansas. FY09 included the move by the Section of Neonatology to the new University Hospital Neonatal Intensive Care Unit (NICU) with 65 private rooms, each with accommodations for parents. This has resulted in a greater emphasis on family centered care and enhanced parental satisfaction. Coupled with the 85 bed NICU at ACH, the total of 150 available NICU beds makes the UAMS Neonatal‐Perinatal training program the largest in the United States. The section cares for approximately 1,900 NICU admissions yearly. The State Outreach/Education Program has been greatly enhanced through a novel telemedicine program which allows immediate visual communication from UAMS and ACH NICU’s to 24 nurseries across Arkansas. These nurseries care for most deliveries in the state outside the Little Rock area. Since the establishment of this program, the state’s neonatal and infant mortality rates have decreased, attesting to the importance of outreach efforts. On July 1, 2008, the advanced newborn screening program began in Arkansas which expanded existing screening to include 29 rare conditions that can be harmful ‐ even fatal – to newborns. This major undertaking has happened smoothly with major collaborations between the Section of Genetics and Metabolism, ACH labs and the Arkansas Department of Health. The program has been a huge success in identifying children with life‐threatening disorders prior to onset of illness. The Emergency Department, in addition to increased patient volume, the acuity of patients, reflected in record numbers of admissions from the emergency department, also grew dramatically. The section implemented several new patient flow strategies in the emergency department, which resulted in stable or lower left without being seen rates in the face of increased volumes. Emergency Department visits grew 7.5% to 47,774 in FY09 compared to 44,433 last year. Annual Report: 2008‐2009 | UAMS Department of Pediatrics The outpatient setting continues to be the growth area for the DOP with an overall 5.1% increase in FY09. For the ACH campus, overall pediatric outpatient visits for the DOP has increased 5.4% with a total of 179,393 visits. 5 The Outpatient Initiative (OPI) was instituted last year to examine clinic and physician efficiency by evaluating physician performance in clinics, clinic utilization, clinic scheduling and patient satisfaction scores to optimize current clinic availability. To date, seven services have been evaluated. Gastroenterology was the first outpatient service to be evaluated last year. After implementation of the recommendations by the OPI, the service saw a 31.9% increase in outpatient visits in FY09 and GI procedures increased by 61% from 772 to 1,246. The increases also overflowed into the inpatient side with a 21% increase in inpatient consults (221 to 321). Other clinics evaluated include Endocrinology, Pulmonary, GCP/Continuity Clinic, Neurology, Adolescent and Nephrology. The last three clinics are in the implementation phase. Despite the loss of one physician FTE in clinic, the Pulmonary Clinic increased physician productivity such that no decline in clinic volume was seen. At the Centers for Children in Lowell, 4,280 outpatient visits occurred in subspecialty clinics alone, a 60.6% increase over last year. Neurology opened a clinic in Lowell in FY09 with a locally based physician and patient visits grew from 388 in FY08 to 1,107 in FY09. Regional subspecialty clinics held in other cities around the state provided 3,846 visits. Patient visits for the Schmieding Developmental Center in Lowell were 2,453, which is a 44% increase over last year. The Dennis Developmental Center on the Little Rock campus continues to grow with 6,737 visits, a 2.3% increase. Annual Report: 2008‐2009 | UAMS Department of Pediatrics In FY09, a Pediatric Diagnostic Clinic was instituted, providing an entry point for patients needing subspecialty evaluation with 390 patient visits since its inception. These patients may need a second opinion or a subspecialty appointment sooner than two weeks. Additionally patients are seen in this clinic when the referring physician is not sure which specialist a patient should see. The clinic receives prompt support from subspecialists when needed. Referring physicians have been very pleased with the clinic. This clinic has greatly assisted the subspecialty clinics in improving patient flow. The Medical Home Clinic for complex medical patients has been expanded to a full‐time outpatient service. In FY09 the clinic saw 1,205 patients, a 59.4% increase in visits over last year. The clinic has continued to expand its efforts to coordinate care for medically complex children, especially NICU graduates with severe bronchopulmonary dysplasia, genetic disorders and major birth defects which required surgery. The clinic follows over 400 of the state’s most vulnerable infants, providing seamless medical care across multiple disciplines. This concept has resulted in excellent outcomes for medically fragile infants, better access to subspecialty care and cost savings for insurers and families. The program was recently awarded 3rd place in the Child Health Corporation of America Race for Results competition among the nation’s leading children’s hospitals, recognizing new and innovative models of care and quality improvement initiatives. 6 The Adolescent service has been involved in the ImPACT concussion management project, beginning to provide pre‐season standardized neuro‐cognitive testing , for‐cause testing after incident , new concussion clinic and staff and community training. The Section of Allergy and Immunology is continuing its work with the Arkansas Emergency Services Association to improve administration of epinephrine for anaphylaxis by all EMTs in Arkansas. An Autism Specialty Clinic was established in 2009 to provide multidisciplinary specialty diagnostic and treatment services for children with autism spectrum disorders. The Endocrinology and Diabetes Clinic has become involved in providing access to a web‐based reporting system for families to record and transmit important patient care data to the diabetes team in order to provide prompt and user‐friendly feedback for diabetes management. A Pediatric Hypertension clinic was officially established to help streamline the care of children with high blood pressure. The ambulatory blood pressure monitoring program increased by 30% in FY09. Expanding programs run by the Section of Hematology & Oncology include the active hematocytopheresis program for sickle cell patients with stroke or recurrent acute chest syndrome and the Comprehensive Bleeding Disorders and Thrombosis Center, for the evaluation and management of this growing group of patients. The Infectious Disease Section along with Pharmacology & Toxicology established the Antimicrobial Stewardship Program, led by Dr. Holly Maples, an affiliate faculty member from the College of Pharmacy, and Dr. Stephanie Stovall from the ID section. In the first year of its existence, the program significantly reduced vancomycin utilization at ACH. The Sections of Critical Care and Cardiology have actively participated in the NACHRI Catheter Associated Blood Stream Infection Collaborative for Intensive Care Units. Both ICUs have achieved success in significantly decreasing the frequency of blood stream infections. Additionally, the NICU with leadership from the Section of Neonatalogy has also decreased markedly the incidence of BSI in their neonates. Quality Improvement projects and research will be a growing facet of the DOP clinical and research programs in the coming years. Research The DOP ended FY08 with $19.9M in total grant funds (annualized direct costs). A total of $13.4M was awarded from federal sources, of which $5.1M was awarded from NIH. Slightly over half, or 56.6% of the dollars are awarded through ACHRI representing 231 active projects and 43.4% through UAMS for 42 projects. Here is an overview of grant activity for FY 08‐09: Sponsor Type # Grants Annualized Direct Costs % of Total NIH 58 $5,118,387.33 25.7% Other Federal 43 $8,240,946.59 41.4% State 34 $2,564,406.42 12.9% Private 109 $3,638,377.02 18.3% CUMG 29 $363,381.89 1.8% TOTAL 273 $19,925,499.25 100.0% Annual Report: 2008‐2009 | UAMS Department of Pediatrics Researchers in the department had a total of 273 projects active during FY09. Of a total of 177 intramural and extramural grant submissions during the period July 1, 2008 through June 30, 2009, 105 were awarded, 24 were not awarded and 48 are still pending outcome. 7 Once again, FY09 was a very successful year for the Department in NIH funding, despite the national downward trend in NIH funding over the last few years. The department’s $5.1M in NIH funding marks a 21.2% increase in NIH funding over FY08 and sets a new record level of NIH funding in the department’s history. The combined UAMS‐DOP/ACHRI NIH grant funding amount has placed the DOP in the second quartile for academic institutions in the USA for the first time in the history of the department. Significant awards from NIH during the last year include a $3.9 million grant awarded to Dr. Charlotte Hobbs from the National Institute of Child Health and Human Development to identify lifestyle exposures and common genetic variants that increase the risk of congenital heart defects. In December, 2008 the Arkansas Center for Birth Defects Research and Prevention received $5 million in renewal funding to be distributed over five years from the Centers for Disease Control and Prevention. The grant will allow the center to continue exploring the causes of birth defects in children from Arkansas and throughout the nation. The Section of Birth Defects Research was awarded a $14.5 million contract from the NIH to establish the Arkansas Center for the National Children’s Study (NCS), which will be conducted in Benton County. The purpose of the NCS is to examine the effects of environmental factors on the health and development of children from before birth to age 21. Benton County has been selected as one of 105 study locations and the only study location in the state of Arkansas. Dr. Laura James was awarded a $475,000 NIH grant to study the identification of new mechanistic biomarkers of adverse responses to acetaminophen in children and adolescents. This will be a collaborative partnership with experts in proteomics and metabolomics from UAMS and within the National Center for Toxicologic Research. Finance & Philanthropy For FY09 the Department of Pediatrics had an exceptionally productive year exceeding all expectations in terms of both financial, clinical and research productivity. All major programs within the department (including the Dennis Developmental Center and KIDS FIRST) exceeded net profit targets with record margins. This record success was achieved in spite of the national economic downturn and increasing pressure from lower overall hospital census and increasing emergency room visits. Highly productive faculty and continued focus on process improvement and efficiency in all our operating areas contributed significantly to achieving financial success for this fiscal year. Four new endowed chairs were funded and one new chair holder was named in FY 08‐09 and investitures were held honoring the following faculty: • Annual Report: 2008‐2009 | UAMS Department of Pediatrics • 8 • • • John Fowlkes, MD, was invested as the inaugural recipient of the James H. Hamlen, II Endowed Chair in Pediatric Endocrinology at ACH funded by a bequest of more than $4 million to ACH from the estate of Little Rock businessman James H. Hamlen, II. G. Bradley Schaefer, MD, became the inaugural recipient of the Committee for the Future Endowed Chair in Genetics at ACH. The endowed chair was created with a $1 million gift to ACH from the Committee for the Future, a volunteer group of young professionals in Pulaski County who support ACH. Jerry G. Jones, MD, was invested as the inaugural recipient of the ACH Auxiliary – Jerry G. Jones, MD, Chair in Child Maltreatment at ACH. The ACH Auxiliary funded the chair in recognition and support of Dr. Jones’ leadership in providing comprehensive, compassionate care for abused children and their families. Gregory B. Sharp, MD, became the inaugural recipient of the John N. Bornhofen, MD Endowed Chair in Pediatric Neurology. The chair was endowed with $1 million from the ACH Allocation Committee and was named in honor of the first pediatric neurologist in Arkansas, Dr. John Bornhofen. Ritu Sachdeva, MD, was invested as the second holder of the Betty Ann Lowe Distinguished Chair in Pediatric Education at ACH. Her project titled “Web‐based Instructional Modules to Simulate Diagnosis and Management of Cardiac Disorders in Children” will provide comprephensive education programs for students, residents and fellows in pediatric cardiology using new technology and simulation. She will hold the chair from July 1, 2009 to June 30, 2012. Annual Report: 2008‐2009 | UAMS Department of Pediatrics Endowed Chairs 9 Department of Pediatrics faculty members currently hold 16 endowed chairs: Chair: 2009: Wal‐Mart Stores, Inc. Endowed Chair in Neonatology Recipient: Robert Arrington, M.D., Chief, Neonatology Section (2009‐present) Chair: 2009: Arkansas Children’s Hospital Committee for the Future Endowed Chair in Genetics Recipient: G. Bradley Schaefer, M.D., Chief, Medical Genetics and Metabolism and Director, UAMS Division of Medical Genetics (2009‐present) Chair: 2009: James H. Hamlen, II Endowed Chair in Pediatric Endocrinology Recipient: John L. Fowlkes, M.D., Chief, Endocrinology Section (2009‐present) Chair: 2009: John N. Bornhofen, M.D. Endowed Chair in Pediatric Neurology Recipient: Gregory B. Sharp, M.D., Chief, Pediatric Neurology Section (2009‐present) Chair: 2008: Arkansas Children’s Hospital Auxiliary‐Jerry G. Jones, M.D. Endowed chair in Child Maltreatment 2008 Recipient: Jerry G. Jones, M.D., Chief, Children at Risk Section (2008‐present) Chair: 2008: Robert H. Fiser, Jr., M.D. Endowed Chair in Pediatrics Recipient: Richard F. Jacobs, M.D., F.A.A.P., Chairman, Department of Pediatrics (2008‐ present) Chair: 2008: Rockefeller Endowed Chair for Children with Special Healthcare Needs Recipient: Eldon G. Schulz, M.D., Chief, Developmental Pediatrics Section (2008‐present) Chair: 2007: James H. Hamlen, II Endowed Chair in Pediatric Pulmonology Recipient: John L. Carroll, M.D., Chief, Pediatric Pulmonary Section (2007‐present) Chair: 2004: Pamela D. Stephens Endowed Chair in Birth Defects Research Recipient: Charlotte A. Hobbs, M.D., Ph.D., Chief, Birth Defects Research (2004‐present) Chair: 2003: Dr. & Mrs. Leeman King Endowed Chair in Pediatric Allergy Recipient: Stacie M. Jones, M.D., Chief, Allergy and Immunology Section (2003‐present) Chair: 2003: Betty Ann Lowe Distinguished Chair in Pediatric Education Recipient: Ritu Sachdeva, M.D., Cardiology (2009‐present) Stephen M. Schexnayder, M.D., Chief, Critical Care Medicine Section (2003‐2009) Chair: 2001: Morris and Hattie Oakley Endowed Chair in Pediatric Critical Care Medicine Recipient: Kanwaljeet “Sunny” Anand, MBBS, D.Phil., Critical Care Medicine (2001‐present) Stephen M. Schexnayder, M.D., Chief, Critical Care Medicine Section (2010‐present) Chair: Recipient: Chair: Recipient: 1998: David and Stephanie Clark Endowed Chair in Pediatric Cardiology W. Robert Morrow, M.D., Chief, Pediatric Cardiology Section (1998‐present) 1995: Harvey and Bernice Jones Endowed Chair in Developmental Pediatrics 1995 Patrick H. Casey, M.D., Center for Applied Research and Evaluation and Vice‐Chair, Faculty Affairs (1995‐present) Annual Report: 2008‐2009 | UAMS Department of Pediatrics Chair: 1995: Harvey and Bernice Jones Endowed Chair in Pediatrics Recipient: Bonnie J. Taylor, M.D., Medical Director, Arkansas Children’s Hospital (2001‐ present) Betty Lowe, M.D., Medical Director, Arkansas Children’s Hospital (1995‐2001) Chair: 1993: Horace C. Cabe Chair in Pediatric Infectious Disease Recipient: José R. Romero, M.D., F.A.A.P., Chief, Infectious Diseases Section (2008‐present) Richard F. Jacobs, M.D., Chief, Infectious Disease Section (1993‐2008) 10 Adolescent Medicine The Adolescent Medicine Section offers several creative responses to new challenges this year. Beyond broad, ongoing clinical and educational responsibilities to the university, hospital and community, the section offers several innovations. The Adolescent Section improves teen health by teaching health providers in the following areas: • • • • Built PULSE center teaching modules and evaluation, using standardized interview scenarios, focusing self efficacy and communication for residents and students. Pediatric Continuity Clinic and Adolescent Faculty began a collaborative curriculum and preception of resident adolescent care at Circle of Friends Clinic five half‐days weekly. Section faculty delivered enhanced lecture series to Family Medicine Residents. Dr. Elton Cleveland advocated in State Legislature as Medical Representative for the Arkansas Academy of Family Physicians, Child Health advisory committee, Nutrition and Obesity, AECCS, and Eye Commission to insure quality care for the children of Arkansas. Clinical programming expansion and improvement efforts abounded. The Adolescent Section has outgrown every current clinical venue. Prime goals for expansion are improved quality, safety, confidentiality, patient access and comfort through infrastructure improvements throughout clinics. The Adolescent Section worked to fulfill the following: • • Expanded Pediatric Diagnostic Clinic hours in Adolescent Center. Eating Disorders Clinic plan to move to more accessible multispecialty space on Cantrell Road in West Little Rock. • Sports Medicine PLUS Team Physician Program outreach sought second Athletic Trainer. • ImPACT concussion management project, began to provide pre‐season standardized neuro‐cognitive testing, for‐cause testing after incident, new concussion clinic and staff and community training. • Outpatient Initiative worked toward plans for Adolescent Center expansion: o Expanded security procedures and resources to meet new challenges. o Computerized triage cleaned charting and prescribing for better outcomes. o Streamlined appointment procedures and templates to meet acute need. o Planned conversion existing AC office space into more clinical space. o Planned to move academic offices off site. • Develop concept and plans for new Adolescent Center. • Expanded Adolescent Diabetes Collaborative with Endocrinology, Type 2 Diabetes clinic. • Establish a translational research collaboration for young women with genital tract infections working with the DOP Chlamydia Research Group In the recruitment area, the Adolescent Section has collaborated with the Emergency Department to develop physician assistance. Members of the Adolescent Section are involved in ongoing collaborative investigation with Allergy and Immunology in Chlamydia, STI risk factors, Syphilis, contraceptive issues and Type 2 Diabetes with Endocrinology. Faculty (Adolescent Medicine) Clinical Educator Assistant Professor Pasold, Tracie L. Woods, Jennifer L. 11 Associate Professor Cleveland, Elton R. Hardin, Brian H. Nesmith, J. Darrell Portilla, Maria G. Annual Report: 2008‐2009 | UAMS Department of Pediatrics Grants (Adolescent Medicine) Primary Investigator/ Project Title Funding Agency Agency Award Number Pending Portilla, Maria Directly‐Observed Monthly Risedronate for Low Bone Mass in Anorexia Nervosa NIH 2066‐1 ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect $0 $0 ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect $25,575 $12,020 Project Dates Budget Year 4/1/2010 4/1/2010 3/31/2015 3/31/2011 Publications (Adolescent Medicine) Journal Articles Ward‐Begnoche WL, Gance‐Cleveland B, Portilla M. Circumventing Communications Barriers with Hispanic‐Speaking Patients Regarding Pediatric Obesity. J Pediatr Health Care. 2009 Jul‐Aug;23(4):272‐280. Book Chapters Ward‐Begnoche WL, Pasold TO,Neill VS, Peck, D, Razzaq S, Young K. Treating Obesity Across the Lifespan. Springer Press; 2008. Chapter 1. Childhood Obesity Treatment Literature Review. Honors & Awards (Adolescent Medicine) Portilla, Maria G. Woods, Jennifer L. Best Doctors in America, 2008 Best Doctors in America, 2009 Best Doctors in America, 2009 Allergy and Immunology The Allergy and Immunology (A/I) Section has expanded clinical services to Northwest Arkansas through focused clinics in primary immunodeficiency disorders and complex allergic disorders. The Section is continuing its work with the Arkansas Emergency Services Association to improve administration of epinephrine for anaphylaxis by all EMTs in Arkansas. The A/I Faculty is actively involved in mentoring resident physicians and students toward academic medicine, in particular to the field of Allergy and Immunology with one resident physician matched to an Allergy and Immunology Fellowship Training Program in 2009. Additionally, two graduate students and five resident physicians have conducted research under the guidance of the A/I Faculty in FY09, resulting in seven abstract presentations at scientific meetings. Drs. Scurlock and Jones received Red Sash Awards in 2009 for Excellence in Teaching within the College of Medicine. Dr. Jones was also awarded the Joan M. Cranmer Mentor of the Year Award in the Department of Pediatrics. The A/I Section has several areas of research focus among its faculty members. Dr. Amy Scurlock’s work in Chlamydia Research and Mucosal Immunity encompasses basic and translational science research. Dr. Scurlock has been awarded a five‐year K08 grant from NIH/NIAID for her work beginning in December 2008. Her work is also supported by the Arkansas Biosciences Institute (ABI) and the Marion B. Lyon New Scientist Development Award. Dr. Tamara Perry’s research, Asthma in the Delta Region of Arkansas (ADRA), focuses on community‐based research in pediatric asthma in the rural Delta region of Arkansas. Dr. Perry is the recipient of the Robert Wood Johnson Foundation Faculty Scholars Award and is a finalist for the Robert Wood Johnson Foundation Harold Amos Faculty Development Program. Her work is also funded through the ABI and the Marion B. Lyon New Scientist Development Award. Drs. Stacie Jones and Richard Kurten conduct research focused on lung health and disease in the Lung Cell 12 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Biology Laboratory. This work is funded through the ABI and Astra Zeneca, Inc. The Food Allergy Research Program, lead by Dr. Stacie Jones, is part of the NIH‐funded Consortium of Food Allergy Research (CoFAR). The Food Allergy Research Program also conducts clinical trials for the development of novel forms of immunotherapy and treatments for food allergy. Particular success has been noted in the development of oral immunotherapy for peanut allergy in collaboration with investigators at Duke University. These research studies have garnered national media and scientific interests in the past year due to exciting advances in therapies for food allergic children that provide hope for better disease outcomes for food allergic patients. Funding for these projects is through the NIH/NIAID, the National Peanut Board, and the Doris and Frank Robins Family. Based on her research successes and leadership within her field, Dr. Perry has also been selected to serve on the Robert Wood Johnson Foundation Physician Faculty Scholars Program Committee to Enhance Diversity in the Program for 2009. Dr. Jones has served as an ad hoc member of an NIH study section during 2008‐2009 and also serves on the NIAID Expert Panel for the development of Food Allergy Diagnosis and Management Guidelines (2008‐ 2010). Faculty (Allergy and Immunology) Instructor Schnackenberg, Bradley J. Clinical Scientist Assistant Professor Perry, Tamara T. Scurlock, Amy M. Associate Professor Jones, Stacie M. Grants (Allergy and Immunology) Primary Investigator/ Project Title Awarded Jones, Stacie CoFAR3‐Oral Desensitization to Egg with Subsequent Induction of Tolerance for Egg‐Allergic Children EDEMA4: A Randomized, Double‐Blind, Placebo‐Controlled, Multi‐Center Study to Assess the Efficacy and Safety of DX‐88 for the Treatment of Acute Attacks of Hereditay Angioedema Immunology of Peanut Allergy and it's Treatment: A Prototype Immunology of Peanut Allergy and it's Treatment: A Prototype:Education Supplement Open‐Label Patient Continuation of DX‐88 for Acute Hereditary Angioedema Attacks, Protocol no DX‐88/19 Oral Immunotherapy for Peanut Allergy Oral Peanut Immunotherapy Sublingual Immunotherapy for Peanut Allergy: A Randomized, Double‐ Blind, Placebo‐Controlled, Phase I/II Pilot Study with a Whole Peanut Extract Perry, Tamara A Multi‐Center, Randomized, Double Blind, Placebo‐Contolled Parallel Group Study of the Safety of Levocetirizine Dihydrochloride Oral Liquid Formulation in Children Aged 6 Months to 11 Months Asthma in the Delta Region of Arkansas (ADRA): Impact of Environmental Factors Impact of Endotoxin and Allergen Exposure on Childhood Asthma in Arkansas Delta Region 13 Funding Agency Agency Award Number NIH CoFAR2/CoFAR3 $12,811 $0 $40,327 Dyax DX88‐20 $10,940 $2,542 $33,270 NIH/NIAID 1240‐16 $327,612 $81,903 $327,612 $81,903 7/1/2005 7/1/2008 6/30/2010 6/30/2009 NIH/NIAID 1240‐14 $18,261 $4,565 $18,261 $4,565 7/1/2005 7/1/2008 6/30/2010 6/30/2009 Dyax 1639‐2 $5,197 $1,106 $15,805 $3,364 4/17/2007 4/17/2007 4/30/2010 4/30/2010 National Peanut Foundation 1765‐2 $101,389 $0 $200,000 $0 9/12/2007 9/12/2007 9/11/2010 8/31/2009 Duke 1178‐4 $10,075 $1,007 $36,932 NIH/NIAID CF4SLIT $7,604 $0 $23,190 $0 4/18/2008 4/18/2008 6/30/2013 6/30/2013 UCB A000423 $15,993 $3,710 $24,285 $5,634 2/26/2008 2/26/2008 2/28/2009 2/28/2009 Robert Wood Johnson Fdtn. 57406 $99,909 $0 $300,000 $0 7/1/2006 7/1/2006 6/30/2009 6/30/2009 Lyon Award 1810‐2 $43,836 $0 $50,000 $0 4/1/2008 4/1/2008 3/31/2010 3/31/2010 Annual Report: 2008‐2009 | UAMS Department of Pediatrics ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect $0 Project Dates Budget Year 5/9/2007 5/9/2007 6/30/2010 6/30/2010 $7,730 4/17/2007 4/17/2007 4/30/2010 4/30/2010 $3,693 2/1/2005 2/1/2006 9/30/2009 9/30/2009 Primary Investigator/ Project Title Scurlock, Amy Immunoregulatory Networks in Chlamydia Genital Tract Infection Polymorphic Membrane Proteins of Chlamydia Trachomatis T Cell Immune Responses Against Chlamydia Trachomatis Infection The T‐helper 17 Immune Response Following Chlamydia trachomatis Genital Tract Infection Pending Scurlock, Amy Immunoregulatory Networks in Chlamydia Genital Tract Infection Perry, Tamara Reducing Asthma Disparities Through School‐Based Telemedicine for Rural Children School‐based Telemedicine for Rural Education on Asthma Management (STREAM) Not Awarded Scurlock, Amy Immunoregulatory Networks in Infection Induced Immunopathology Funding Agency Agency Award Number ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect Project Dates Budget Year NIH 1K08AI077932‐01A1 $67,537 $5,403 $122,500 NIH/NIAID 1634‐2 $25,124 $9,547 $90,580 $34,420 Genocea Chlamydia Vaccine $24,044 $9,726 $29,509 $11,936 6/30/2008 6/30/2008 5/5/2010 5/5/2010 Lyon Award 1599‐2 $19,974 $0 $50,000 $0 4/1/2007 4/1/2007 4/30/2009 4/30/2009 NIH 1K08AI077932‐01A1 $0 $0 $48,000 $1,840 5/1/2009 5/1/2009 4/30/2011 4/30/2010 NIH 2059‐1 $0 $0 $306,488 $128,210 4/1/2010 4/1/2010 3/31/2015 3/31/2011 Robert Wood Johnson Fdtn. 2018‐1 $0 $0 $93,750 AAAI 1952‐1 $0 $0 $50,000 $9,800 12/25/2008 12/25/2008 11/30/2013 11/30/2009 5/1/2006 5/1/2006 4/30/2009 4/30/2009 $11,250 1/10/2010 1/1/2010 12/31/2014 12/31/2010 $0 7/1/2009 7/1/2009 6/30/2011 6/30/2010 Publications (Allergy and Immunology) Journal Articles Burks AW, Jones SM, Berseth CL, Harris C, Sampson H, Scalabrin D. Hypoallergenicity and effects on growth and tolerance of a new amino acid‐based formula with docosahexaenoic acid and arachidonic acid. J Peds 2008 153:266 ‐ 271. Halterman JS, Lynch KA, Conn KM, Hernandez TE, Perry TT, Stevens T. Environmental Exposures and Respiratory Morbidity among Very Low Birth Weight Infants at One Year of Life. Arch Dis Child 2009 94(1):28‐32. Heulitt MJ, Jones SM, Holt SJ, Thurman TL, Jo C, Simpson PM. Repeated measurements of respiratory mechanics in developing rats utilizing a forced oscillation technique. Experimental Lung Research 2008 Sep;34(7):409‐23. Hofmann AM, Scurlock AM, Jones SM, Palmer KP, Lokhnygina Y, Steele PH, Kamilaris J, Burks AW. Safety of a peanut oral immunotherapy protocol in children with peanut allergy. J Allergy Clin Immunol 2009 May 26; ePub ahead of print Hopkins R, Kennedy J, Magee J, Perry T. Adolescent and adult asthma: Guidelines for stepwise treatment. J Ark Med Soc 2008 December; 105(6):132‐133. Perry TT, Vargas PA, Bufford J, Feild CR, Flick M, Simpson PM, Hamilton RG, Jones SM. Classroom Aeroallergen Exposure in Arkansas Head Start Centers. Ann Allergy Asthma Immunol 2008 100:368‐363. Perry TT, Vargas PA, McCracken A, Jones SM. Under‐diagnosed and Uncontrolled Asthma: Findings in Rural Schoolchildren in the Delta Region of Arkansas. Ann Allergy Asthma Immunol 2008 101:375‐381. Scurlock AM, Burks AW, Jones SM. Oral Immunotherapy for Food Allergy. Curr Allergy Asthma Rep 2009 May; 9(3):186‐193. 14 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Tan C, Hsia RC, Shou H, Haggerty CL, Ness RB, Gaydos CA, Dean D, Scurlock AM, Wilson DP, Bavoil PM. Chlamydia trachomatis‐infected patients display variable antibody profiles against the nine‐member polymorphic membrane protein family. Infec Immun. 2009 Aug;77(8):3218‐26. Valet, RS Perry TT, Hartert TV. Rural Health Disparities in Asthma Care and Outcomes. J Allergy Clin Immunol 2009 123(6):1220‐1225. National Professional Positions (Allergy and Immunology) Editorial/Study Section Activities Jones, Stacie M. NIH Study Section: Center for Scientific Review Speicial Emphasis Panel Family Management and Food Allergy, Grant Review, 2008‐2009 Other National Professional Positions Jones, Stacie M. American Academy of Allergy, Asthma and Immunology, Member, Food Allergy, Anaphylaxis, Dermatology and Drug Allergy Interest Section, 1992 ‐ 2008 American Academy of Allergy, Asthma and Immunology, The Allergy and Asthma Disease Management Center, Consultant for "Ask the Expert", 2008 Honors & Awards (Allergy and Immunology) Jones, Stacie M. Perry, Tamara T. Scurlock, Amy M. 15 Best Doctors in America, 2008 Joan M. Cranmer Mentor of the Year Award, University of Arkansas for Medical Sciences, Dept. of Pediatrics, 2009 Nominee and Finalist for Outstanding Woman Faculty Award, Women's Faculty Faculty Development Caucus, University of Arkansas for Medical Sciences, 2008 Red Sash Award for Excellence in Teaching, University of Arkansas for Medical Sciences, 2008 Red Sash Award for Excellence in Teaching, University of Arkansas for Medical Sciences, 2009 Robert Wood Johnson Faculty Scholar, The Robert Wood Johnson Foundation, 2006 ‐ 2009 Role Model Award, Minority Access, Inc., 2007 ‐ 2008 Best Doctors in America, 2008 Best Doctors in America, 2009 Red Sash Award for Excellence in Teaching, University of Arkansas for Medical Sciences, 2009 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Biostatistics The Biostatistics Program within the DOP cultivates collaborative research between methodologist and clinical and biomedical investigators. Its mission is to provide statistical and database support to the clinical and biomedical researchers while advancing the reputation and research capacity of the department. The program includes three faculty, six staff and one intern who have so far supported 20 sections within the DOP, as well as the Arkansas Children’s Nutrition Center and the Division of Pediatric Anesthesia within the University’s Department of Anesthesia. In March of 2009, Dr. Todd G. Nick joined the program as permanent Director and UAMS faculty. Dr. Nick previously served as Professor in the Division of Biostatistics and Epidemiology in the Department of Pediatrics at Cincinnati Children’s Hospital Medical Center. Faculty (Biostatistics) Research Scientist Research Assistant Professor Jo, Chan‐Hee Instructor Gomez‐Acevedo, Horacio Basic Scientist Professor Nick, Todd G. Grants (Biostatistics) Primary Investigator/ Project Title Funding Agency Agency Award Number Not Awarded Gomez‐Acevedo, Horacio Mathematical Models for the Immune Response to Environmental Toxicants NSF 1937‐1 ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect $0 $0 ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect $159,782 $75,098 Project Dates Budget Year 4/1/2009 4/1/2009 3/31/2012 3/31/2010 Publications (Biostatistics) Journal Articles Badger TM, Ronis MJ, Wolff GL, Stanley JS, Ferguson ME, Shankar K, Simpson PM, Jo CH. Soy Protein Isolate Reduces Hepatosteatosis in Yellow Avy/a Mice Without Altering Coat Color Phenotype. Exp Biol Med (Maywood). 2008 Oct; 233(10):1242‐1254. Heulitt MJ, Jones SM, Holt SJ, Thurman TL, Jo C, Simpson PM. Repeated measurements of respiratory mechanics in developing rats utilizing a forced oscillation technique. Experimental Lung Research 2008 Sep;34(7):409‐23. Myer GD, Ford KR, Barber Foss KD, Liu C, Nick TG, Hewett TE. The relationship of hamstrings and quadriceps strength to anterior cruciate ligament injury in female athletes. Clin J Sport Med 2009 Jan; 19(1):3‐8. Nick TG, Saldana SN. Pharmacogenetics and pharmacogenomics: Statistical challenges in design and analysis. Chance 2009 Feb. Prausa SE, Fukuda T, Maseck D, Curtsinger KL, Liu C, Zhang K, Nick TG, Sherbotie JR, Ellis EN, Goebel J, Vinks AA. UGT genotype may contribute to adverse events following medication with mycophenolate mofetil in pediatric kidney transplant recipients. Clin Pharmacol Ther. 2009 May;85(5):495‐500. 16 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Sadhasivam S, Cohen LL, Szabova A, Varghese A, Kurth CD, Willging P, Wang Y, Nick TG, Gunter J. Real‐time assessment of perioperative behaviors and prediction of perioperative outcomes. Anesth Analg 2009 Mar; 108(3):822‐6. Schmitz ML, St. Amour ED, Holt SJ, Thurman TL, Jo C, Killebrew P, Jaquiss RJ. Effects of angiotensin‐converting enzyme inhibition on thromboelastography for infants and children presenting for elective cardiac surgery. Blood 2008 112(11):1225. Varughese AM, Nick TG, Gunter J, Wang Y, Kurth CD. Factors predictive of poor behavioral compliance during inhalational induction in children. Anesthesia and Analgesia 2008 Aug; 107(2):413‐21. Wall EJ, Vourazeris J, Myer GD, Emery KH, Divine JG, Nick TG, Hewett TE. The healing potential of stable juvenile osteochondritis dissecans knee lesions. J Bone Joint Surg Am 2008 Dec; 90(12):2655‐64. Ward‐Begnoche W, Gance‐Cleveland B, Simpson P, Parker J, Jo C, Dean J, Thompson J. Effectiveness of a school‐ based obesity prevention program. International Journal of Health Promotion and Education 2009:51‐56. National Professional Positions (Biostatistics) Editorial/Study Section Activities Jo, Chan‐Hee NIH Challenge Grants Review, Grant Review, 2009‐present Nick, Todd G. Journal of Pharmacogenetics and Genomics, Editorial Board, 2008‐2009 Other National Professional Positions Nick, Todd G. American Statistical Association, Chair‐Elect Section on Statistical Consulting, 2009 Honors & Awards (Biostatistics) Gomez‐Acevedo, Horacio Travel Award, MidSouth Computational Biology and Bioinformatics Society, 2008 ‐ 2009 Birth Defects Research Through synergistic collaborations, the Section of Birth Defects Research combines surveillance, research, and prevention to make a difference in the lives of children and their families. In FY09, the Section continued collecting samples and analyzing data for the National Birth Defects Prevention Study, the DNA Bank for Congenital Malformations study for “cutting‐edge” research in human genomics, and the Metabolic Determinants of Congenital Heart Defect Risk study. The Section was one of five sites to be awarded a competitive renewal for the National Birth Defects Prevention Study and remains a top contributor among the participating study sites. In order to further enhance the Section’s abilities to research the causes of birth defects, the Section received funding from the Arkansas Biosciences Institute to investigate epigenetic causes of congenital heart defects. DNA methylation is a key epigenomic phenomenon that may be altered during early pregnancy and embryonic development. 17 Annual Report: 2008‐2009 | UAMS Department of Pediatrics A notable achievement for the Section of Birth Defects Research in the past fiscal year was being awarded a $14.5 million contract from the NIH to establish the Arkansas Center for the National Children’s Study (NCS), which will be conducted in Benton County. The purpose of the NCS is to examine the effects of environmental factors on the health and development of children from before birth to age 21. Benton County has been selected as one of 105 study locations and the only study location in the state of Arkansas. The Section’s recruitment efforts led to a valuable addition to the research team. Dr. Stephen Erickson joined the Section from the University of Alabama in the spring of 2009. Dr. Erickson’s experience and training in statistical genetics, especially in copy number variation, provides the Section with the ability to expand genomic research efforts to whole genome association studies. In an effort to promote graduate and medical education, the Section of Birth Defects Research faculty mentor junior faculty, fellows, residents, medical students and graduate students in Clinical Translational Science and Bioinformatics. Section researchers also continued to publish research findings in many well respected journals, including the American Journal of Epidemiology and Pediatrics. All of these efforts during the past year continuously point back to the mission of the Section of Birth Defects Research, which is to reduce the prevalence of birth defects in Arkansas and the nation, as well as to decrease the psychological, social, and economic impact of birth defects. Faculty (Birth Defects Research) Clinical Scientist Professor Hobbs, Charlotte A. Basic Scientist Assistant Professor Blossom, Sarah Erickson, Stephen W. Professor Cleves, Mario A. Research Scientist Research Assistant Professor MacLeod, Stewart L. Grants (Birth Defects Research) Primary Investigator/ Project Title Awarded Blossom, Sarah Prenatal Cigarette Smoke Exposure and Neuroimmune Networks Hobbs, Charlotte AR Centers of Excellence for Surveillance, Research Services, and Evaluation Aimed at Birth Defects Administrative Supplement Providing Summer Research Experiences for Students and Science Educators Arkansas Reproductive Health Monitoring System (ARHMS) Centers for Birth Defects Research and Prevention (CBDRP) Genetic and metabolic determinants of Congenital Heart Defect Risk National Children's Study Pending Blossom, Sarah Maternal Immunoregulatory Pathways in a Mouse Model of Congenital Heart Defects Mechanisms of Trichloroethylene‐Induced T Cell Alterations and Adverse Neurological Outcome Hobbs, Charlotte Gene‐Nutrient Etiologies of Neural Tube Defects ‐ Stanford Sub 18 Funding Agency Agency Award Number Arkansas Biosciences Institute 1932‐2 CDC U50/CCU613236‐10 NIH 3R01HD039054‐08S1 State of AR ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect Project Dates Budget Year $7,438 $0 $15,000 $0 6/1/2009 6/1/2009 5/31/2011 5/31/2010 $314,639 $78,660 $1,754,164 $438,541 9/1/2002 8/1/2006 11/30/2008 11/30/2008 $1,895 $891 $9,666 $4,543 6/1/2009 6/1/2009 10/31/2009 10/31/2009 382‐10 $599,179 $0 $1,200,000 $0 7/1/2007 7/1/2007 6/30/2009 6/30/2009 CDC 1U01DD000491‐01 $464,658 $116,164 $800,000 $200,000 12/1/2008 12/1/2008 11/30/2013 11/30/2009 NIH/NICHD 2 R01 HD039054‐08 $592,278 $225,066 $592,278 $225,066 NIH/NICHD 1858‐2 $244,085 $101,578 $320,471 $133,367 9/26/2008 9/26/2008 9/25/2013 9/25/2009 NIH 1996‐1 $0 $0 $50,000 $23,500 12/1/2009 12/1/2009 11/30/2011 11/30/2010 NIH 1876‐2 $0 $0 $150,000 $64,500 12/1/2009 12/1/2009 11/30/2011 11/30/2010 NIH 2067‐1 $0 $0 $63,406 Annual Report: 2008‐2009 | UAMS Department of Pediatrics $29,801 8/1/2006 7/1/2008 6/30/2011 6/30/2009 9/1/2009 9/1/2009 8/31/2010 8/31/2010 Primary Investigator/ Project Title Genetic and metabolic determinants of Congenital Heart Defect Risk ‐ Recovery Act Funds for Admin. Supplement Not Awarded Blossom, Sarah Immunoregulatory Role of Maternal Prostaglandin D2 in a Mouse Model of Environmental‐Toxicant‐Induced Congenital Heart Defects Neuroimmune Consequences of Early Life Trichloroethylene Exposure Hobbs, Charlotte Centers for Birth Defects Research and Prevention 1 Month Cost Extension Request Funding Agency Agency Award Number ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect Project Dates Budget Year NIH/NICHD 5R01HD039054‐09 $0 $0 $291,996 $137,238 8/1/2009 8/1/2009 6/30/2011 7/30/2010 American Heart Association 1980‐1 $0 $0 $63,637 $6,363 7/1/2009 7/1/2009 6/30/2011 6/30/2010 NIH 2048‐1 $0 $0 $360,425 $151,787 10/1/2009 10/1/2009 9/30/2011 9/30/2010 CDC 1929‐2 $0 $0 $43,077 $13,509 11/30/2008 11/30/2008 12/31/2008 12/31/2008 Publications (Birth Defects Research) Journal Articles Allen EG, Freeman SB, Druschel C, Hobbs CA, O'Leary LA, et al. Maternal age and risk for trisomy 21 assessed by the origin of chromosome nondisjunction: a report from the Atlanta and National Down Syndrome Projects. . Human Gent. 2009 Feb; 125(1):4 Bird TM, Robbins J, Druschel C, Hobbs CA, Romitte PA, Austin AA, Tyler M, Reading JA, Burnett W. Demographic and environmental risk factors for gastroschisis and omphalocele in the National Birth Defects Prevention Study. J Pediatr Surg. 2009 Aug;44(8):1546‐51. Blossom SJ, Doss JC, Hennings LJ, Jernigan S, Melnyk S, James SJ. Developmental Exposure to Trichloroethylene Promotes CD4 T cell differentiation and hyperactivity in association with oxidative stress and neurobehavioral deficits in MRL +/+ mice. Toxicol Appl Pharmacol. 2008 Sep 15; 231(3):344‐53. Bruder CE, Piotrowski A, Gijsbers ACJ, Andersson R, Erickson S, et al. Phenotypically Concordant and Discordant Monozygotic Twins Display Different DNA Copy‐Number‐Variation Profiles. American Journal of Human Genetics 2008 82:1‐9. Burke BL, Robbins JM, Bird TM, Hobbs CA, Nesmith C, Tilford JM. Trends in hospitalizations for neonatal jaundice and kernicterus in the United States: 1998 to 2005. Pediatrics 2009 Feb; 123(2):524‐32. Correa A, Gilboa SM, Besser LM, Botto LD, Moore CA, Hobbs CA, Cleves M, Riehle‐Colarusso TJ, Waller DK, Reece EA. Diabetes mellitus and birth defects. AM J Obstet Gynecol. 2008 Sep; 199(3):237. Erickson S. A likelihood‐ratio test of twin zygosity using molecular genetic markers. Twin Research and Human Genetics 2008 11(1):41‐43. Freeman SB, Torfs CP, Romitti PA, Royle MH, Druschel C, Hobbs CA, et al. Congenital gastrointestinal defects in Down syndrome: a report from the Atlanta and National Down Syndrome Projects. Clin Genet. 2009 Feb; 75(2):180‐4. Gilbert KM, Przybyla B, Pumford NR, Han T, Fuscoe J, Schnackenberg LK, Holland RD, Doss JC, Macmillan‐Crow LA, Blossom SJ. Delineating liver events in trichloroethylene‐induced autoimmune hepatitis. Chem. Res. Toxicol. 2009. April 22; 4:626‐632 Gilbert KM, Pumford NR, Blossom SJ. Comments on Lifetime exposure to trichloroethylene (TCE) does not accelerate autoimmune disease in MRL+/‐ mice. J. Env. Sci. Health Tox. Hazard Subst. Environ. Eng. 2009. January; 44(1):117‐ 122. 19 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Guimbellot JS, Erickson S, Mehta T, Wen H, Page GP, et al. Correlation of microRNA Levels During Hypoxia With Predicted Target mRNAs Through Genome‐wide Microarray Analysis. BMC Medical Genomics. 2009 Mar 25;2:15. Henry GD, Kansal NS, Callaway M, Grigsby T, Henderson J, Noble J, Palmer T, Cleves MA, Ludlow JK, Simmons CJ, Mook TM. Centers of excellence concept and penile prostheses: an outcome analysis. Urol 2009 Mar; 181(3):1264‐8. James S, Blossom, SJ.Doss, J. Hennings, L. Jernigan S. Melnyk, S. Developmental Exposure to Trichloroethylene PRomotes CD4+ T CEll. Toxicology and Applied Pharmacology 2008 231:344‐353. James SJ, Rose S, Melnyk S, Jernigan S, Blossom S, Pavliv O, Gaylor DW. Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism. FASEB J. 2009. March 23; ePub Johnson CY, Honein MA, Hobbs CA, Rasmussen SA. Prenatal diagnosis of orafacial clefts, the National Birth Defects Prevention Study, 1998‐2004. Prenat Diagn. 2009 May 19. Karve S, Cleves M, Helm M, Hudson TJ, West DS, Martin BC. An empirical basis for standardizing adherence measures derived from administrative claims data among diabetic patients. Med Care 2008 Nov; 46(11):1125‐1133. Mendiratta P, Tilford JM, Prodhan P, Cleves MA, Wei JY. Trends in hospital discharge disposition for elderly patients with infective endocarditis. AM Geriatr Soc 2009 May; 57(5):877‐81. Mosley BS, Cleves M, Siega‐Riz AM, Shaw GM, Canfield MA, Waller DK, Werler MM, Hobbs CA. Neural Tube Defects and Maternal Folate Intake Among Pregnancies Conceived After Folic Acid Fortification in the United States. Am J Epidemiol. 2009 Jan 1; 169(9):9‐17 Reefhuis J, Honein MA, Schieve LA, Correa A, Hobbs CA, et al. Reply: ART and major structural birth defects in the USA. Human Reproduction 2009 April ; 24(2):360‐6. Rose S, Melnyk S, Savenka A, Hubanks A, Jernigan S, Cleves MA, James SJ. The Frequency of Polymorphysms Affecting Lead and Mercury Toxicity among Children with Autism. Amer J Biochem and Biotechnology. 2008; 4(2):85‐ 94 Todorova V, Vanderpool D, Blossom S, Nwokedi E, Hennings L, Mrak R, Klimberg VS. Oral glutamine protects against cyclophosphamide‐induced cardiotoxicity in experimental rats through increase of cardiac glutathione. Nutrition. 2009 Jul‐Aug;25(7‐8):812‐7. Wineinger NE, Kennedy RE, Erickson S, Wojcynski MK, Bruder CE, et al. Statistical Issues in the Analysis of DNA Copy Number Variations. International Journal of Computational Biology and Drug Design 2008 1(4):368‐395. Book Chapters Ali N, MacLeod S, Hine J, Chowdhury P. Apoptosis in Carcinogenesis and Chemotherapy. Hong Kong: Springer; 2008. Cellular Signaling Mechanisms in Pancreatic Apoptosis. Erickson S, Kim K, Allison DB. Meta‐analysis and Combining Information in Genetics and Genomics. 2009. Composite Hypothesis Testing: An Approach Built on Intersection‐Union Tests and Bayesian Posterior Probabilities. Books Cleves M, Gould W, Gutierrez RC, Marchenko Y. An Introduction to Survival Analysis Using Stata, Second Edition. College Station, TX: Stata Press; 2008. 372 p. 20 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Honors & Awards (Birth Defects Research) Cleves, Mario A. Erickson, Stephen W. Hobbs, Charlotte A. Charles C. Shepard Science Award Assessment and Epidemiology, U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Agency for Toxic Substances and Disease Registry, 2009 Post‐Doctoral Fellowship (T32 HL072757), NIH, 2006 ‐ 2009 Postdoctoral Career Enhancement Award, UAB Office of Postdoctoral Education, 2008 Charles C. Shepard Science Award Assessnent and Epidemiology, U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Agency for Toxic Substances and Disease Registry, 2009 Deans Distinguished Faculty, University of Arkansas for Medical Sciences, 2008 Cardiology The Pediatric Cardiology Section of the DOP is a nationally recognized section and continues to grow in clinical, educational and research arenas. Clinical activity continues to be at all time high volumes making the Section’s clinical service one of the busiest in the US. The faculty, 15 cardiologists, three intensivists and one doubly boarded intensivist/cardiologist attend on three full time inpatient services. In addition, the Section has successfully recruited an additional cardiologist to join the heart failure team and provide support for imaging services. The Cardiology team covers 15 intensive care beds and 16 telemetry ward beds as well as serving the PICU, NICU and general pediatric wards with consult services. The Section continues to support the congenital cardiac surgery program which performed a record 309 open heart procedures in FY09. Section members provide 24/7 in house attending coverage to the cardiac surgery program. The program performed 259 open procedures with benchmark hospital survival for CV surgery of 97%. The Section continues to participate in the IDE trial of the Berlin Heart EXCOR, the only ventricular assist device for infants and small children under study in the country. The heart transplant program also continues to be one of the busiest pediatric heart transplant programs in the country with 25 transplants in calendar FY09. The electrophysiology service continues to attract regional and national referrals for cryo‐ablation without fluoroscopy and complex electrophysiology procedures. This experience is one of the largest and has the best clinical outcomes of any reported experience. Other clinical initiatives include weekly cardiology clinics at the Centers for Children in Lowell, Arkansas as well as monthly clinics in other locations in the state. Daily echocardiography, ECG, and Holter service at the Centers for Children are provided by the Section in addition to same day interpretation via telemedicine. The telemedicine echocardiography service also supports three other facilities in Northwest and West Arkansas and continues to grow. The Cardiology Section has also initiated a new state wide program in fetal cardiac diagnosis and management called the Fetal Heart Center. Under the leadership of Dr. Renee Bornemeier and in collaboration with ACH and the Department of Obstetrics and Gynecology, this program aims to provide physicians and families with a comprehensive and exemplary program to diagnose and care for fetuses with cardiac conditions providing excellent clinical care in addition to direction, education, supportive services, and research opportunities to directly impact morbidity and mortality of infants with heart disease in Arkansas. 21 Annual Report: 2008‐2009 | UAMS Department of Pediatrics This is the second year of the pediatric cardiology fellowship program and the first of the pediatric cardiology national match. The program will grow by two additional fellows in FY10 and (a total of seven fellows in FY10). Both second year fellows presented their research in the Young Investigator Award competition at the American Academy of Pediatrics Cardiology Section meeting in October of 2008 and one was the recipient of a the AAP travel grant. Of the first year fellows, all have research that has been accepted for presentation at the Cardiology and Congenital Heart Surgery Section annual meeting at the AAP National Conference and Exhibition. In addition, Dr. Ritu Sachdeva was awarded the Betty Lowe Chair in Pediatric Education for her proposal “Web based Instructional Modules to Simulate Diagnosis and Management of Cardiac Disorders in Children.” There were 18 publications from the Cardiology Section in FY09. Dr. Sadia Malik continues with ongoing support from her KO8 award for her grant entitled “Maternal Smoking: DNA Repair Polymorphisms and the Risk of Septal Heart Defects.” In addition Dr. Volkan Tuzcu is co‐investigator for the RO1 grant “Physiological Disturbances Associated with Neonatal Intraventricular Hemorrhage” awarded to Dr. Jeff Kaiser in the Neonatology Section of the Department. Dr.Adnan Bhutta was awarded an FDA contract for the study “Assessment of the pharmacokinetics, pharmacodynamics, and neurotoxic effects of an anesthetic in infants undergoing various surgical procedures” in response to the FDA RFP Safety of Key Inhaled and Intravenous Drugs in Pediatrics (SAFEKIDS) Initiative. Sadly, the Cardiology Section, the Department, and the School of Medicine lost a great leader in pediatric cardiology and pediatric education with the death of Dr. W. Thompson Dungan, the pioneering pediatric cardiologist who brought modern heart care to Arkansas in 1959. Dr. James Fasules left the section as well to become the Vice President for Policy and Advocacy for the American College of Cardiology. Faculty (Cardiology) Instructor Delgado‐Corcoran, Claudia Clinical Attending Clinical Assistant Professor Angtuaco, Sylvia Clinical Educator Assistant Professor Eble, Brian K. Garcia, Xiomara Prodhan, Parthak Sachdeva, Ritu Vyas, Himeshkumar Associate Professor Best, Thomas H. Bornemeier, Renee A. Dyamenahalli, Umesh Fontenot, Eudice E. Seib, Paul M. Professor Fasules, James W. Frazier, Elizabeth A. Moss, M. Michele Tuzcu, Volkan Clinical Scientist Assistant Professor Bhutta, Adnan T. Associate Professor Malik, Sadia Professor Morrow, William R. Professor Emeritus Dungan, W. T. Grants (Cardiology) Primary Investigator/ Project Title Awarded Bhutta, Adnan Use of Ketamine prior to cardiopulmonary bypass in children Dyamenahalli, Umesh A Phase III, Open‐Label, Non‐Randomized, International, Multi‐center Trial to Evaluate the Efficacy and Safety of Cardiolite Myocardial perfusion Imaging in Ped subject with Kawasaki Dz 22 Funding Agency Agency Award Number American Heart Association 1162‐3 $21,825 $2,182 $130,000 $13,000 Bristol Meyers Cardiolite 301 US $11,534 $2,843 $126,020 $31,068 Annual Report: 2008‐2009 | UAMS Department of Pediatrics ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect Project Dates Budget Year 1/1/2006 1/1/2006 12/31/2008 12/31/2008 2/1/2006 1/1/2017 2/1/2006 1/1/2017 Primary Investigator/ Project Title Garcia, Xiomara A Phase II, Multicenter, Randomized, Double‐Blind, Placebo‐ Controlled, Parallel Group Study to Detemine the PD of Sodium Nitroprusside during Prolonged Infusion in Pediatric Subjects Malik, Sadia Maternal Smoking, Cytochrome p450 Polymorphisms and the Risk of Congenital Heart Disease Maternal Smoking, DNA Repair Polymorphisms and the Risk of Septal Heart Defects Tobacco exposure and risk of congenital heart defects Seib, Paul An Ongoing Evaluation of the Safety and Efficacy of the CardioSEAL Septal Occlusion System with Qwik Load in Patients with Ventricular Septal Defect Tuzcu, Volkan Predictors of Inappropriate Therapy Delivery by Implantable Cardioverter Defibrillators in Children Pending Malik, Sadia Maternal Smoking, DNA Repair Polymorphisms and the Risk of Septal Heart Defects Funding Agency Agency Award Number ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect Project Dates Budget Year Duke N01‐HD‐4‐3385 $17,192 $8,080 $30,612 American Heart Association 1443‐3 $32,722 $3,272 $130,000 NIH 1K08HL090494‐01A1 $120,250 $9,620 $120,250 NIH 1 R03 HD050663‐02 $24,242 $9,212 $48,550 $18,449 7/1/2006 7/1/2007 6/30/2009 6/30/2009 NMT VSD2002 $480 $103 $10,500 $2,250 1/4/2005 1/4/2005 8/30/2008 8/30/2008 Boston Scientific 1815‐2 $15,519 $3,880 $25,480 $6,370 2/14/2008 2/14/2008 1/31/2009 1/31/2009 NIH 1K08HL090494‐02 $0 $0 $117,716 $9,417 7/10/2008 7/1/2009 6/30/2013 6/30/2010 $14,388 12/17/2008 12/17/2008 11/30/2009 11/30/2009 $13,000 1/1/2007 1/1/2007 12/31/2008 12/31/2008 $9,620 7/10/2008 7/10/2008 6/30/2013 6/30/2009 Publications (Cardiology) Journal Articles Bornemeier RA, Eble B, Jaquiss RDB, Imamura M. Repair of an anomalous left coranary artery from the pulmonary artery in a premature neonate. Congenital Heart Disease 2008 de Caen A, Reis A, Bhutta A. Vascular Access and Drug Therapy in Pediatric Resuscitation. Pediatr Clin North Am. 2008 Aug; 55(4):909‐27. Eble B. "Not one more child" Preventing sudden death through The Antony Hobbs Project. Pediatric Commentary 2008 Imamura M, Dossey AM, Prodhan P, Schmitz ML, Frazier E, Dyamenahalli U, Bhutta A, et al. Bridge to Cardiac Transplant in Children: Berlin Heart versus Extracorporeal Membrane Oxygenation. Annals of Thoracic Surgery 2009 87:1894‐1901. Mendiratta P, Tilford JM, Prodhan P, Cleves MA, Wei JY. Trends in hospital discharge disposition for elderly patients with infective endocarditis. AM Geriatr Soc 2009 May; 57(5):877‐81. O'Brien C, Harik N, James L, Seib P, Stowe C. Cesium‐Induced QT‐Interval Prolongation in an Adolescent. Pharmacotherapy 2008 August; 28(8):1059‐65. Prodhan P, Dela Rosa RS, Shubina M, Haver KE, Matthews BD, Buck S, Kacmarek RM, Noviski NN. Wheeze detection in the pediatric intensive care unit: comparison among physician, nurses, respiratory therapists, and a computerized respiratory sound. Respir Care. 2008 Oct; 53(10):1304‐9. Prodhan P, Fiser RT, Cenac S, Bhutta AT, Fontenot E, Moss M, Schexnayder S, Seib P, Chipman C, Weygandt L, Imamura M, Jaquiss RD, Dyamenahalli U. Intrahospital transport of children on extracorporeal membrane oxygenation: Indications, process, interventions, and effectiveness. Pediatr Crit Care Med. 2009 Jul 9. 23 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Prodhan P, Greenberg B, Bhutta A.,Hyde c, Vankatesan A, Imamura M, Jaquiss RD, Dyamenahalli U. Recombinant Human Deoxribonuclease Improves Atelectasis in Mechanically Ventilated Children with Cardiac Disease. Congenit Heart Dis. 2009 May;4(3):166‐73. Prodhan P, Westra SJ, Lin J, Karni‐Sharoor S, Regan S, Noviski N. Chest radiological patterns predict the duration of mechanical ventilation in children with RSV infection. Pediatr Radiol. 2009 Feb; 39(2):117‐23. Rockett SR, Bryant JC, Morrow WR, Frazier E, et al. Preliminary Single Center North American Experience with the Berlin Heart Pediatric EXCOR Device. ASAIO J. 2008 Sep‐Oct; 54(5):479‐82. Rovnaghi CR, Garg S, Hall RW, Bhutta AT, Anand KJS. Ketamine analgesia for inflammatory pain in neonatal rats: a factorial randomized trial examining long‐term effects. Behav Brain Funct. 2008 Aug 7; 4:35. Sachdeva R, Seib P, Frazier L, et al. Percutaneous Coronary Intervention Using Drug‐eluting Stents in Pediatric Heart Transplant Recipients. Pediatr Transplant. 2008 Dec 15:1399‐3046. Sachdeva R. Echocardiographic Evaluation of Patent Ductus Arteriosus and Aorto‐Pulmonary Collaterals. Pediatric Ultrasound Today 2008 13(5) Schmitz ML, Massicotte P, Faulkner SC, Bhutta A, et al. Management of a pediatric patient on the Berlin Heart Excor ventricular assist device with argatroban after heparin‐induced thrombocytopenia. ASAIO journal 2008 Sept/Oct; 54(5):546‐547. Stroud MH, Prodhan P, Moss MM, Anand KJS. Redefining the golden hour in pediatric transport. Pediatr Crit Care Med 2008 July; 9(4):435‐437. Tuzcu V, Nas S, Ulusar U, Ugur A, Kaiser JR. Altered Heart Rhythm Dynamics in Very Low Birth Weight Infants with Impending Intraventricular Hemorrhage. Pediatrics 2009 123:810‐815. Book Chapters Lin A, Ghaffar S, Belmont J. Congenital Cardiovascular Malformations‐Stevenson Book of Malformations. Moss M, Simone S. Textbook of Pediatric Intensive Care. 4th ed. Lippincott Williams and Wilkins; 2008. Chapter p 46‐ 55. Physical Design and Personnel Organization of the PICU. Prodhan P. Pediatric Fundamental Critical Care Support. 1 ed. Society of Critical Care Medicine; 2008. Chapter 22. Sedation Analgesia and neuromascular blockade. National Professional Positions (Cardiology) Other National Professional Positions Garcia, Xiomara Society of Critical Care Medicine, member, section PEDS, 1999 ‐ present Morrow, William R. American Academy of Pediatrics, Cardiology Executive Committee, 2002 ‐ present 24 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Moss, M. Michele Prodhan, Parthak American College for Critical Care Medicine, Board of Regents, 2005 ‐present American College for Critical Care Medicine, Credentialing Committee, 2006 ‐ present American College for Critical Care Medicine, Secretary, General, 2008 ‐present American College for Critical Care Medicine, Vice ‐ Chancellor, 2009 ‐present American Heart Association, Council on Cardiopulmonary and Critical Care, 1988 ‐ present American Heart Association, Council on Cardiovascular Disease in theYoungm 1988 ‐ present Pediatric Critical Care Colloquium, Steering Committee, 1996 ‐ present Society for Critical Care Medicine, Nominating Committee, 2007 ‐ 2009 Society of Critical Care Medicine, MCKAAP, Member, 2007 ‐ present Honors & Awards (Cardiology) Bhutta, Adnan T. Bornemeier, Renee A. Eble, Brian K. Frazier, Elizabeth A. Moss, M. Michele Prodhan, Parthak Sachdeva, Ritu 25 Visiting Professor, University of Tennessee Health Science Center, Le Bonheur Children's Medical Center, TN, 2008 Best Cardiologist in America, 2008 Best Doctors in America, 2008 Best Doctors in America, 2008 Red Sash Award for Excellence in Teaching, University of Arkansas for Medical Sciences, 2009 Best Doctors in America, 2008 Best Doctors in America , 2009 Best Doctors in America, 2008 Red Sash Award for Excellence in Teaching, University of Arkansas for Medical Sciences, 2009 Presidential Citation Award, Society for Critical Care Medicine, Chicago, 2008 Betty Lowe Distinguished Chair, Pediatric Education, 2009 Educator of the Year, UAMS, 2009 Emerging Faculty Program, ACC Foundation, 2008 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Center for Applied Research & Evaluation (CARE) The Center for Applied Research and Evaluation (CARE) is a multidisciplinary group of health services and behavioral science researchers within the UAMS DOP. CARE, based on the ACH campus, conducts research in a number of thematic areas, including the impact of obesity, injuries, and chronic diseases of childhood. CARE methods include epidemiologic studies, community‐based interventions, applied clinical research, and multi‐site, longitudinal research. CARE faculty published more than 25 peer‐reviewed articles in the 2008‐2009 academic year, with multiple abstracts and presentations in regional, national, and international settings. Faculty (CARE) Clinical Scientist Assistant Professor Kuo, Dennis Z. Associate Professor Thompson, Joseph W. Professor Aitken, Mary E. Casey, Patrick H. Basic Scientist Assistant Professor Bowman, Stephen Associate Professor Weber, Judith L. Professor Robbins, James M Research Scientist Research Professor Fryer, George E. Grants (CARE) Primary Investigator/ Project Title Awarded Aitken, Mary Arkansas Safe Routes to School Program Building Consensus for Graduate Drivers License for Teen Drivers Child Passenger Safety Education Child Passenger Safety Education Development and Evaluation of Targeted ATV Safety Educational Strategies for Rural Children Development and Evaluation of Targeted ATV Safety Educational Strategies for Rural Children Mapping the Way to Success: Statewide Dissemination and Evaluation Planning for the Arkansas Safe Routes to School Program Strike Out Child Passenger Injury Strike Out Child Passenger Injury Bowman, Steve Injury Patterns, Outcomes and Disparities in People with Epilepsy Casey, Pat CSNAP 2007‐08 26 Funding Agency Agency Award Number Arkansas State Highway Commission 1636‐2 $73,172 $27,805 $129,641 Allstate Foundation 1707‐2 $9,367 $1,405 $43,476 NHTSA OP‐2008‐03‐07‐01 $41,530 $6,230 $165,217 $24,783 10/1/2007 10/1/2007 9/30/2008 9/30/2008 NHTSA OP‐2009‐03‐07‐01 $123,573 $18,536 $165,217 $24,783 10/1/2008 10/1/2008 9/30/2009 9/30/2009 HRSA H34MC08514 $28,997 $4,349 $171,173 $25,676 9/1/2007 9/1/2007 8/31/2010 8/31/2008 HRSA H34MC08514‐02 $144,372 $21,656 $173,913 $26,087 9/1/2007 9/1/2008 8/31/2010 8/31/2009 Arkansas State Hwy and Transportation Dept 1844‐2 $68,232 $29,340 $108,561 $46,681 10/27/2008 10/27/2008 3/8/2010 3/8/2010 CDC 1 R49 CE000975‐02 $165,294 $48,298 $259,647 $75,868 2/19/2007 2/19/2008 2/18/2010 2/18/2009 CDC 1 R49 CE000975‐03 $94,344 $29,626 $190,251 $59,744 2/19/2007 2/19/2009 2/18/2010 2/18/2010 Epilepsy Foundation 1832‐2 $50,000 $0 $50,000 $0 7/1/2008 7/1/2008 6/30/2009 6/30/2009 Boston Medical 1594‐2 $23,182 $2,318 $65,388 $6,539 8/1/2007 8/1/2007 12/31/2008 12/31/2008 Annual Report: 2008‐2009 | UAMS Department of Pediatrics ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect Project Dates Budget Year $49,264 12/1/2007 12/1/2007 4/2/2009 4/2/2009 $6,521 8/1/2007 8/1/2007 9/30/2008 9/30/2008 Primary Investigator/ Project Title Funding Agency Agency Award Number ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect CSNAP 2008 CSNAP 2009 Robbins, Jim AR Centers of Excellence for Surveillance, Research Services, and Evaluation Aimed at Birth Defects CDC Supplement‐Health related quality of life and risky behavior of adolescents with craniofacial malformations‐Ark Follow‐up Study of Children Affected by Craniofacial Malformations Hospital Utilization CSNAP‐Maryland Pre‐Teen Followup Study of Children Affected by Cranofacial Malformations Thompson, Joe Arkansas SCI 2007 Coverage Institute Development Grant Defining and Classifying Diseases & Risks Linked to Childhood Obesity Defining and Classifying Diseases & Risks Linked to Childhood Obesity Weber, Judith Delta Physical Activity 2010 Lower Mississippi Delta NIRI (PHASE III) School Partnership for Obesity Research and Prevention (SPORT) Pending Aitken, Mary Child Passenger Safety Education Development and Evaluation of Targeted ATV Safety Educational Strategies for Rural Children Improving Teen Driving Through Parental Responsibility Kuo, Dennis Family‐to‐Family Health Information Center Weber, Judith Increasing School Bonding through Gardening to Reduce Obesity and Other Risk Behaviors in Children in the Delta Not Awarded Aitken, Mary Arkansas Injury Prevention and Research Center School Challenge for Safer Teen Driving (Drive Smart Challenge) Weber, Judith Health Food and Fitness News Projects Boston Medical 1853‐2 $77,496 $7,750 $122,720 $12,272 1/1/2008 1/1/2008 7/31/2009 7/31/2009 Boston Medical 1853‐4 $60,317 $6,032 $121,633 $12,163 1/1/2009 1/1/2009 12/31/2009 12/31/2009 CDC 261‐24 $10,056 $2,514 $80,051 $20,012 9/1/2002 8/1/2005 11/30/2008 11/30/2008 CDC U50/CCU613236‐10 $14,349 $3,587 $80,000 $20,000 9/1/2002 8/1/2006 11/30/2008 11/30/2008 CDC 1381‐2 $5,767 $1,442 $101,952 $25,488 9/1/2005 9/1/2005 8/31/2008 8/31/2008 University of Maryland 1563‐2 $16,855 $1,703 $50,611 $5,115 7/1/2006 7/1/2006 6/30/2009 6/30/2009 CDC 1381‐4 $6,866 $1,716 $80,950 $20,238 9/1/2005 9/1/2006 8/31/2008 8/31/2008 Robert Wood Johnson Foundation 63867 $119,156 $14,299 $178,571 $21,429 2/1/2008 2/1/2008 7/31/2009 7/31/2009 Robert Wood Johnson Foundation 57821 $289,602 $29,017 $692,775 $69,413 12/1/2006 12/1/2007 11/30/2009 11/30/2008 Robert Wood Johnson Foundation 57821 $412,810 $41,388 $710,734 $71,257 12/1/2006 12/1/2008 11/30/2009 11/30/2009 USDA 1924‐2 $88,943 $8,894 $409,091 $40,909 9/15/2008 9/15/2008 9/14/2013 9/14/2013 USDA 58‐6251‐4‐023 $240,777 $24,078 $1,204,545 Robert Wood Johnson Fdtn. 1750‐2 $29,765 $3,572 $53,557 $6,427 11/1/2007 11/1/2007 4/30/2009 4/30/2009 NHTSA 36463‐1 $0 $0 $165,787 $24,312 10/1/2009 10/1/2009 9/30/2011 9/30/2011 HRSA H34MC08514‐02 $0 $0 $173,913 $26,087 9/1/2007 9/1/2009 8/31/2010 8/31/2010 NHTSA 2053‐1 $0 $0 $227,461 $68,238 8/1/2009 8/1/2009 7/30/2011 7/30/2010 HRSA 1969‐1 $0 $0 $5,943 $1,010 6/1/2009 6/1/2009 5/31/2012 5/31/2010 USDA 2025‐1 $0 $0 $409,091 $40,909 10/1/2009 10/1/2009 9/30/2013 9/30/2010 CDC 1928‐1 $0 $0 $641,476 $263,991 7/31/2009 7/31/2009 7/30/2014 7/30/2010 AR Dept of Human Services 1939‐1 $0 $0 $13,636 $1,364 7/1/2009 7/1/2009 6/30/2012 6/30/2010 Allen Foundation Inc. 1970‐1 $0 $0 $47,956 $7,194 7/1/2009 7/1/2009 6/30/2010 6/30/2010 $120,455 Project Dates Budget Year 9/1/2004 9/1/2004 8/31/2009 8/31/2009 Publications (CARE) Journal Articles Aitken ME, McCarthy ML, Slomine BS, Ding R, Durbin DR, Jaffe KM, Paidas CN, Dorsch AM, Christensen JR, MacKenzie EJ. Family burden after traumatic brain injury in children. Pediatrics 2009 Jan; 123(1):199 ‐ 206. 27 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Bird TM, Robbins J, Druschel C, Hobbs CA, Romitte PA, Austin AA, Tyler M, Reading JA, Burnett W. Demographic and environmental risk factors for gastroschisis and omphalocele in the National Birth Defects Prevention Study. J Pediatr Surg. 2009 Aug;44(8):1546‐51. Bowman SM, Aitken ME, Helmkamp JC, Maham SA, Graham CJ. Impact of helmets on injuries to riders of all‐terrain vehicles. Injury Prevention 2009 Feb; 15(1):3 ‐ 7. Bowman SM, Bird TM, Aitken ME, Tilford JM. Trends in hospitalizations associated with pediatric traumatic brain injuries. Pediatrics 2008 Nov; 122(5):988 ‐ 993. Bowman SM, Zimmerman FJ, Christakis DA, Sharar SR. The role of hospital profit status in pediatric spleen injury management. Med Care 2008 March; 46(3):331‐338. Bowman SM, Zimmerman FJ, Sharar SR, Baker MW, Martin DP. Rural trauma: Is trauma designation associated with better hospital outcomes? . J Rural Health 2008 Summer; 24(3):263‐268. Burke BL, Robbins JM, Bird TM, Hobbs CA, Nesmith C, Tilford JM. Trends in hospitalizations for neonatal jaundice and kernicterus in the United States: 1998 to 2005. Pediatrics 2009 Feb; 123(2):524‐32. Chilton MM, Black M, Berkowitz C, Casey P. Food Insecurity and Risk for Poor Health among U.S. Born Children of Immigrants. Amer J of Public Health 2009 (99):556‐562. Cook JT, Frank DA, Casey, PH, et al. A Brief Indicator of Household Energy Insecurity: Association with Food Insecurity, Child Health and Child Development in U.S. Infants and Toddlers. Pediatrics 2008 122:e867‐e875. Cutler CB, Fryer GE, Miyoshi TJ, Weitzman M. Increased rates and severity of child and adult food insecurity in households with adult smokers. Archives of Pediatrics and Adolescent Medicine 2008 162(11):1056‐62. DeVoe JE, Wallace LS, Fryer GE. Does patient age influence perceptions about healthcare communication?. Family Medicine 2009 41(2):126‐133. DeVoe JE, Wallace LS, Fryer GE. Measuring patients' perceptions of communication with healthcare providers: Do differences in demographic and socioeconomic characteristics matter? Health Expect. 2009 Mar;12(1):70‐80. Devoe JE, Wallace LS, Pandhi N, Solotaroff R, Fryer GE. Comprehending care in a medical home: a usual source of care and patient perceptions about healthcare communication. J Am Board Fam Med 2008 Sep 21 (5): 441 ‐ 450. Farrell VA, Harris M, Lohman TG, Going SB, Thomson CA, Weber JL, Houtkooper LB. Comparison between dietary assessment methods for determining associations between nutrient intakes and bone mineral density in postmenopausal women . J Am Diet Assoc. 2009 May;109(5):899‐904. Grosse SD, Flores AL, Ouyang L, Robbins J, Tilford JM. Impact of Spina Bifida on parental caregivers: Findings from a survey of Arkansas families. J Child Fam Stud 2009 Feb; e‐pub Helmkamp JC, Aitken ME, Lawrence BA. ATV and bicycle deaths and associated costs in the United States, 2000‐ 2005. Public Health Reports 2009 May; 124(3):409 ‐ 418. Kancherla V, Romitti PA, Damiano PC, Druschel CM, Robbins J. Maternal reports of satisfaction with care and outcomes for children with microtia. Plastic and Reconstructive Surgery 2009 Apr; 123(4):149e‐150e. 28 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Langlois PH, Ramadhani TA, Royle M, Robbins J, Scheuerle AE, Wyzynski DF. Birth defects and military service since 1990. Military Medicine 2009 Feb; 174(2):170‐6. Rittenhouse DR, Fryer GE, Phillips RL, Miyoshi T, Nielsen C, Goodman DC, Grumbach K. Impact of Title VII training programs on community health center staffing and national health service corps participation. Ann Fam Med 2008 Sep 6 (5): 397 ‐ 405. Rust G, Ye J, Baltrus P, Daniels E, Adesunloye B, Fryer GE. Practical barriers to timely primary care access: impact on adult use of emergency department services. Arch Intern Med 2008 Aug 11 168 (15): 1705 ‐ 1710. Tanios AT, Lyle RE, Casey PH. ACH Medical Home Program for Special Needs Chidren. A New Medical Era. J Ark Med Soc. 2009 Jan; 105(7):163‐5. Thompson JW, Card‐Higginson P. Arkansas's Experience in Informaing Parents and Conducting Statewide Surveillance of Child and Adolescent Obesity Epidemic. Pediatrics Supplement 2008 Thompson TM, Latch R, Parnell D, Dick R, Aitken ME, Graham J. Foot injuries associated with all‐terrain vehicle use in children and adolescents. Pediatr Emerg Care. 2008 Jul;24(7):466‐7. Wallace LS, Devoe JE, Bennett IM, Roskos SE, Fryer GE. Perceptions of healthcare providers' communication skills: do they differ between urban and non‐urban residents?. Health Place 2008 Dec 14 (4): 653 ‐ 660. Wallace LS, Devoe JE, Heintzman JD, Fryer GE. Language Preference and Perceptions of Healthcare Providers' Communication and Autonomy Making Behaviors among Hispanics. J Immigr Minor Health 2008 Sep 24. Whiteside‐Mansell L, Bradley RH, Casey, PH, Fussell JJ, Conners‐Burrow NA Triple Risk: Do Difficult Temperament and Family Conflict Increase the Likelihood of Behavioral Maladjustment in Children Born Low Birth Weight and Preterm? J Pediatr Psychol. 2009 May;34(4):396‐405. Wong‐Gibbons DL, Kancherla V, Romitti PA, Tyler MC, Damiano PC, Druschel CM, Robbins J, Kizelnik‐Freilich S, Burnett W. Maternal reports of satisfaction with care and outcomes for children with craniosynostosis. J Craniofac Surg. 2009 Jan;20(1):138‐42 Woolf SH, Johnson RE, Fryer GE, Rust G, Satcher D. The health impact of resolving racial disparities: an analysis of US mortality data. Am J Public Health 2008 Sep 98 (9 Suppl): S26 ‐ S28. Book Chapters Casey P. Developmental‐Behavioral Pediatrics. Fourth ed. Philadelphia, PA: Saunders/Elsevier; July, 2009. Chapter 60. Failure to Thrive. National Professional Positions (CARE) Editorial/Study Section Activities Bowman, Stephen National Medical Research Council, Singapore Ministry of Health, Grant Review, 2005‐2008 Casey, Patrick H. Journal of Developmental and Behavioral Pediatrics, Editorial Board, 2003‐present. 29 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Fryer, George E. Journal of Aggression and Violent Behavior, Editorial Board, 1995‐present Kuo, Dennis Z. AAP News, Editorial Board, 2008‐present Newsletter Editor, Section on Young Physicians, AAP, Editor, 2004‐2008 Robbins, James M Arkansas Children's Hospital Dean's CUMG grant competition, Grant Review, 2001‐present Weber, Judith L. United States Department of Agriculture, CSREES National Research Initiative (NRI) Proposals, Human Nutrition and Obesity Section, Grant Review, 2004‐ present Other National Professional Positions Aitken, Mary E. Ambulatory Pediatrics Association, Injury Prevention Special Interest Group, Group, 1995 ‐ present American Academy of Pediatrics, Section on Injury, Violence, and Poison Prevention (SOIVPP), Executive Committee, 2005 ‐ present American Academy of Pediatrics, Section on Injury, Violence, and Poison Prevention (SOIVPP), Program Chair, 2008 ‐ present American Public Health Association, Epidemiology Section, State Chapter Liason, 1994 ‐ present American Public Health Association, Injury Control and Emergency Health Services Section, 1996 ‐ present Kuo, Dennis Z. Chapter Guide to Young Physicians development committee, AAP, Chair, 2006 ‐ 2008 School and Community Health Special Interest Group, Academic Pediatrics Association, Chair, 2008 ‐ present Thompson, Joseph W. AcademyHealth Board of Directors, Board Member, 2007 ‐ present Committee on Childhood Obesity Prevention, Institute of Medicine, Washington, DC, Committee Member, 2008 ‐ present National Committee for Quality Assurance ‐ Obesity Measurement Advisory Panel, Advisory Member, 2006 ‐ present Robert Wood Johnson Clinical Scholars Program ‐ National Advisory Committee / Leadership Training Program, Advisory Member, 2004 ‐present Robert Wood Johnson Foundation ‐ Synthesis Project Advisory Group, Advisory Member, 2006 ‐ present 30 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Weber, Judith L. American Dietetic Association, National Nominating Committee for Research DPG, Chair, 2009 ‐ 2010 American Dietetic Association, National Nominating Committee for Research DPG, Two Year Term, 2007 ‐ 2009 Honors & Awards (CARE) Casey, Patrick H. Kuo, Dennis Z. Thompson, Joseph W. 31 Betty A. Lowe Award, Arkansas Children's Hospital, 2008 CHCA RACE For Results Award, Third Place for Medical Home Clinic for Special Needs Children, Child Health Corporation of America, 2009 Leadership Award, American Academy of Pediatrics, Maryland Chapter, 2008 Marion B. Lyon New Scientest Development Award, Marion B. Lyon Revocable Trust, 2009 Southern Society of Pediatric Research Young Faculty Award, Southern Society of Pediatric Research, 2009 Arkansas MADD Community Champions Award, MADD, Mothers Against Drunk Driving, 2009 Leadership Award , Community Health Centers of Arkansas, 2008 Health Quality Award, National Committee for Quality Assurance, 2008 Power List for Health Care, Arkansas Business, 2008 Public Health through Public Policy Award, UAMS Fay W. Boozman College of Public Health, 2008 Public Policy & Advocacy Award, Academic Pediatric Association, 2008 The John Atkinson Ferrell Prize for Outstanding Contributions to Preventive Medicine and Public Health, 2009 Translating Research to Policy Award, Active Living Research, 2008 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Children at Risk The Children at Risk Section had a very good FY09. A highlight was receipt of the Arkansas Children’s Hospital Auxiliary Jerry G. Jones, M.D. Chair in Child Maltreatment, one of only a handful of such chairs in the field of child abuse pediatrics in the United States. Proceeds from the chair, as well as additional funds provided by the ACH Auxiliary and individuals, have permitted increased clinical and educational endeavors. Another highlight was receipt of a Masters of Public Health degree by a section member, Dr. Karen Farst. Funds from the chair have permitted an increase of resident teaching in the medical outpatient facility of the Arkansas Children’s House. The SHIPS (Support of Health Involved Professionals in Child Safety Centers) Medical program has provided training, peer review and continuing education of nurses who perform sexual abuse examinations in children’s advocacy centers in this first full year of operation. Telemedicine units were installed in centers in Hot Springs, Pine Bluff, Springdale, and Rogers, and two additional units have been purchased. Section faculty performed a needs assessment regarding community mental health training of family advocates in children’s advocacy centers and therapists in mental health centers of Arkansas. Results were presented to the Arkansas Task Force on Child Abuse and Neglect in September 2008. Family Treatment Program staff provided supervision and clinical experience for trainees from UALR School of Social Work, University of Central Arkansas Graduate Psychology Department, UAMS College of Nursing, and Philander Smith undergraduates in addition to regular observation experiences for UAMS residents. The Arkansas Children’s House staff continues to provide multidisciplinary outpatient medical evaluations of physically and sexually abused children for referral agencies and physicians. A satisfaction survey of the referral agencies, conducted in January 2009, included questions on courteousness, expertise, accessibility and response timeliness. The overall mean score was 3.66 on a 1 – 4 scale with 4 being excellent. A survey of patients regarding services provided by the Family Treatment Program (FTP) and Adolescent Sexual Adjustment Project (ASAP) was conducted in October 2008. The overall Child/Adolescent Patient Satisfaction Ratings were excellent, with a mean score of 3.71. Overall Parent/Patient Satisfaction Ratings were also exceptional for these programs, with a mean score of 3.75 utilizing the same scale. Similarly, Stakeholder (Referral Agency) Satisfaction Ratings for FTP and ASAP services were outstanding, with respective overall mean scores of 3.78 and 3.6. General comments from all of these surveys regarding services were very positive. Advocacy has remained a responsibility due to the leadership position of this section in the field of child maltreatment. Policy and practice have been improved in Arkansas through staff membership on the Arkansas Commission on Child Abuse, Rape and Domestic Violence and its subcommittees, the Arkansas Legislative Task Force on Child Abuse and Neglect, the Arkansas Task Force on Drug Endangered Children, the Arkansas Crime Victims Reparations Board of the Attorney General’s Office, and the Advisory Board of the Arkansas Division of Children and Family Services. Dr. Karen Farst received an Outstanding Service Award from the National Children’s Alliance for her work with children’s advocacy centers. Faculty (Children at Risk) Instructor Rauls, Stanley D. Clinical Attending Clinical Assistant Professor Clemmons, John C. Clinical Associate Professor Church, Janice K. Worley, Karen B. 32 Clinical Educator Assistant Professor Farst, Karen J. Professor Jones, Jerry G. Annual Report: 2008‐2009 | UAMS Department of Pediatrics Grants (Children at Risk) Primary Investigator/ Project Title Awarded Farst, Karen Trends in Child Maltreatment Hospitalization in Young Children from 1997‐2005 Worley, Karen Technical Assistance for Sexual Abuse Management Teams Funding Agency Agency Award Number Ambulatory Pediatric Association 1789‐2 DOJ NA ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect $9,891 $0 $9,891 $55,422 $5,543 $103,525 $0 Project Dates 7/1/2008 7/1/2008 6/30/2009 6/30/2009 $10,353 12/1/2008 12/1/2008 12/31/2009 12/31/2009 Publications (Children at Risk) Journal Articles Church JK, Pulliam E. Helping children manage stress. Parenting in Arkansas 2008 Fall/Winter; 18(2):4‐6. Jones J, Worthington T. Genital and Anal Injuries Requiring Surgical Repair in Females Less than 21 Years of Age. Journal of Pediatric and Adolescent Gynecology 2008 Aug; 21(4):207‐211. National Professional Positions (Children at Risk) Other National Professional Positions Church, Janice K. American Psychological Association (APA), Member, Section on Child Maltreatment, Division 27(Child, Youth, and Family Services), 1993 ‐ present American Psychological Association (APA), Program Proposal Reviewer for the 2002 APA Convention, Division 43(Family Psychology), 2002 ‐ present Farst, Karen J. Helfer Society for Child Abuse, Full Member, Program Committee Member, 2008 ‐ 2009 National Alliance for Drug Endangered Children, Medical Work Group, 2008 ‐ present Jones, Jerry G. American Professional Society on the Abuse of Children, Media Relations Committee, 1997 ‐ present Worley, Karen B. Association for the Treatment of Sexual Offenders, Public Policy Committee, 2005 ‐ present Association for the Treatment of Sexual Offenders, State Public Policy Representative, 1996 ‐ present 33 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Budget Year Honors & Awards (Children at Risk) Church, Janice K. Farst, Karen J. Arkansas Crime Victims Reparations Board, Chair, Arkansas Crime Victims Reparations Board, 2008 Invited Program Proposal Reviewer for the 2009 Annual Convention of the Southeastern Psychological Association, 2008 Outstanding Service Award for Medical Care, National Children's Advocacy Center, 2009 Young Investigator Grant Award, Academic Pediatric Association, 2008 Jones, Jerry G. Worley, Karen B. Arkansas Children's Hospital Auxililary ‐ Jerry G. Jones, M.D. Chair in Child Maltreatment, 2008 Miracle of Hope Award, Safe Places, 2008 Community Pediatrics This was a strong year for Community Pediatrics. Faculty began quarterly clinic coverage at the Centers for Children in northwest Arkansas, which will be expanded to bi‐monthly next year. The Section provides one physician to the newly formed Disaster Medical officer cadre at Children’s Hospital. The UAMS Head Start programs continue to be among the largest grants in the institution, and were recognized for strengths in community partnerships during the triennial monitoring from the Head Start Bureau. The Section continues to emphasize medical student teaching. The partnership with the Mid Delta Community Health Center marked its 15th year, with faculty and medical students providing excellence in care and advocacy to the Delta underserved. Faculty served as mentors again the summer of 2009 for two undergraduates in the Arkansas Commitment program for identified talented African American Arkansans. Faculty (Community Pediatrics) Clinical Educator Assistant Professor Udouj, Janet M. Professor Feild, Charles R. Grants (Community Pediatrics) Primary Investigator/ Project Title Awarded Feild, Charles Bayou Meto HS Quality Approval Grant 9/07 ‐ 9/08 Davis HS Quality Approval 3/08 ‐ 3/09 Examining the Cultural Competency of the Services of the St. Louis Healthy Start Project ML King HS Quality Approval 10/08‐10/09 34 Funding Agency Agency Award Number DHHS NA $133 $0 $600 $0 9/20/2007 9/20/2007 9/19/2008 9/19/2008 DHHS NA $699 $0 $1,000 $0 3/13/2008 3/13/2008 3/12/2009 3/12/2009 The Arnold P. Gold Foundation SS‐08‐001 $2,078 $0 $3,000 $0 5/15/2008 5/15/2008 10/14/2008 10/14/2008 DHHS NA $848 $0 $1,200 $0 10/16/2008 10/16/2008 10/15/2009 10/15/2009 Annual Report: 2008‐2009 | UAMS Department of Pediatrics ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect Project Dates Budget Year Primary Investigator/ Project Title Funding Agency Agency Award Number Metro HS Quality Approval 05/08 ‐ 05/09 PY08 Head Start Continuation Funding PY09 Head Start COLA Funding ‐ 3.06% permanent increase to base funding PY09 Head Start Continuation Funding PY09 Head Start Continuation Funding (Patti Bokony Oral Health Initiative) Silver City HS Quality Approval Grant 1/08 ‐ 1/09 USDA ‐ Special Nutrition Programs ‐ Head Start FY08 USDA ‐ Special Nutrition Programs ‐ Head Start FY09 Pending Feild, Charles National Center for Physical Development and Outdoor Play "Head Start Body Start Play Space Grant" PY09 Early Head Start American Recovery and Reinvestment Act (ARRA) funding: temporary COLA 1.84% + Quality Improvement PY09 Early Head Start COLA Funding ‐ 3.06% permanent increase to base funding DHHS NA DHHS/ACF 06 CH7001/10 DHHS/ACF 06CH7001/01 S DHHS/ACF ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect $0 Project Dates Budget Year 5/7/2008 5/6/2009 5/7/2008 5/6/2009 $510 $0 $600 $1,893,489 $390,307 $5,634,285 $1,161,402 11/1/2005 11/1/2007 10/31/2008 10/31/2008 $111,193 $23,351 $167,708 $35,219 11/1/2008 11/1/2008 10/31/2009 10/31/2009 06CH7001/11 $2,346,461 $465,703 $3,539,084 $702,403 11/1/2005 11/1/2008 10/31/2009 10/31/2009 DHHS/ACF 06CH7001‐11 $41,096 $8,630 $61,984 $13,017 11/1/2006 11/1/2008 10/31/2009 10/31/2009 DHHS NA $433 $0 $800 $0 1/15/2008 1/15/2008 1/14/2009 1/14/2009 USDA Q0027 $145,579 $0 $579,150 $0 10/1/2006 10/1/2007 9/30/2008 9/30/2008 USDA Q0027 $435,618 $0 $582,420 $0 10/1/2006 10/1/2008 9/30/2009 9/30/2009 DHHS/ACF 36547‐1 $0 $0 $7,108 $949 9/1/2009 9/1/2009 9/30/2010 9/30/2010 DHHS/ACF S12 $0 $0 $24,459 $5,136 7/1/2009 7/1/2009 9/30/2010 9/30/2010 DHHS/ACF S12 $0 $0 $10,965 $2,303 11/1/2008 11/1/2008 10/31/2009 10/31/2009 Publications (Community Pediatrics) Journal Articles Perry TT, Vargas PA, Bufford J, Feild CR, Flick M, Simpson PM, Hamilton RG, Jones SM. Classroom Aeroallergen Exposure in Arkansas Head Start Centers. Ann Allergy Asthma Immunol 2008 100:368‐363. Honors & Awards (Community Pediatrics) Feild, Charles R. Best Doctors in America ‐ General Pediatrics, 2009 Best Doctors in America ‐ General Pediatrics, 2008 Medicine Merit Badge, UAMS, 2009 Public Health Merit Badge, 2009 Critical Care Medicine The Critical Care Section continues to provide consultation and care for the region’s most critically ill and injured children. In addition to providing state of the art care in the Donald W. Reynolds Pediatric Intensive Care Unit, faculty provide clinical care as part of the Sedation Team, as cardiac intensivists in the Heart Center, and in the Emergency Department. During the past academic year, the PICU team continued to be both successful locally and a national leader in the reduction of catheter‐related blood stream infections through a collaborative affiliated with the National Association of Children’s Hospitals and Related Institutions (NACHRI). The critical care fellowship program, now approaching its 20th year of accreditation, was reaccredited for the longest permissible cycle length, five years. All trainees scored above the national average on their in‐training exam. The section is involved in a number of 35 Annual Report: 2008‐2009 | UAMS Department of Pediatrics research endeavors and is one of six PICU nationally that are part of the Collaborative Pediatric Critical Care Research network, funded by the National Institutes of Health. Dr. Ron Sanders, a former fellow in the Critical Care training program, joined the faculty after nine years of academic practice in North Carolina and Florida. Faculty (Critical Care Medicine) Instructor Stroud, Michael H. Clinical Educator Associate Professor Fiser, Richard T. Green, Jerril W. Sanders, Ronald C. Professor Schexnayder, Stephen M. Clinical Scientist Professor Fiser, Debra H. Heulitt, Mark J. Basic Scientist Associate Professor Al‐Chaer, Elie D. Grants (Critical Care Medicine) Primary Investigator/ Project Title Awarded Al‐Chaer, Elie Allergan Drug Testing on Rats Allergan Drug Testing on Rats Allergan Drug Testing on Rats Microglia in Chronic Visceral Pain Sex Hormones and Visceral Hypersensitivity Sex Hormones and Visceral Hypersensitivity Heulitt, Mark Development and validation of a pediatric mechanical ventilator mode Evaluation of NIV and nCPAP in an animal model Schexnayder, Steve A Multicenter, Open‐Label, Single and Multiple Dose Pharmacokinetic Study of IV Pantoprazole in preterm Infants 0‐11 Months with a Clinical Diagnosis of GERD or need for Acid …… A Phase I, Randomized, Open‐Label, Multi‐National Study to Evaluate the Pharmacokinetics of Repeated Once‐Daily Intravenous Doses of Esomeprazole in Pediatric Patients 0 to 17 Years Old, Inclusive Pending Al‐Chaer, Elie Subaward ‐ Spinal Microglial Mechanisms of Visceral Hypersensitivity Sanders, Ron Critical Asthma in Pediatrics Stroud, Michael Goal‐directed Resuscitative Interventions during Pediatric Inter‐ facility Transport (The GRIPIT Trial) 36 Funding Agency Agency Award Number Allergan n/a $73,783 $30,989 $221,550 $93,051 9/1/2004 1/1/2007 12/31/2009 12/31/2009 Allergan NA $124,493 $52,287 $249,669 $104,861 9/1/2004 12/31/2007 12/31/2009 12/31/2009 Allergan NA $118,823 $53,470 $239,616 $107,827 1/1/2009 1/1/2009 12/31/2009 12/31/2009 NIH/NIDDK 1 R21 DK081628‐ 01A1 $83,488 $31,464 $168,360 $63,450 6/1/2009 6/1/2009 5/31/2011 5/31/2010 NIH/NIDDK 1 R01 DK077733‐ 01A2 $156,772 $70,156 $212,500 $95,094 4/1/2008 4/1/2008 3/31/2013 3/13/2009 NIH/NIDDK 5 R01 DK077733‐02 $105,377 $47,420 $212,500 $95,625 4/1/2008 4/1/2009 3/31/2013 3/31/2010 Maquet 1587‐2 $166,814 $41,826 $488,106 $122,386 1/1/2007 1/1/2007 12/31/2008 4/10/2009 G.E. NIV/nCPAP $9,424 $2,356 $50,807 ULRF PANTO‐01 $4,575 $1,144 $16,960 $4,240 AstraZeneca D9615C00021 $12,118 $2,846 $28,850 $6,775 8/16/2007 8/16/2007 12/31/2009 12/31/2009 NIH/NINDS 33331‐1 $0 $0 $45,000 $20,250 12/1/2009 12/1/2009 11/30/2011 11/30/2010 NIH 2063‐1 $0 $0 $58,176 $27,343 9/30/2009 9/30/2009 9/29/2011 9/29/2010 NIH/NICHD 1826‐2 $0 $0 $78,898 $37,082 Annual Report: 2008‐2009 | UAMS Department of Pediatrics ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect Project Dates Budget Year $12,702 12/12/2007 12/12/2007 3/31/2008 8/15/2008 3/1/2009 3/1/2009 12/31/2010 12/31/2010 7/1/2009 7/1/2009 6/30/2011 6/30/2010 Primary Investigator/ Project Title Not Awarded Sanders, Ron PCCM Network: Endothelial Progenitor Cells in Pediatric Acute Lung Injury Stroud, Michael Goal‐directed Resuscitation Interventions during Pediatric Inter‐ facility Transport (The GRIPIT Trial) Funding Agency Agency Award Number ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect NIH 1170‐13 $0 $0 $184,075 American Heart Association 1973‐1 $0 $0 $63,428 Project Dates Budget Year $86,515 12/1/2009 12/1/2009 11/30/2014 11/30/2010 $3,003 7/1/2009 7/1/2009 6/30/2011 6/30/2010 Publications (Critical Care Medicine) Journal Articles Anand KJ. Analgesia for skin‐breaking procedures in newborns and children: what works best? CMAJ. 2008 Jul 1; 179(1):11‐2. Anand KJS, Anderson BJ, Holford NHG, Hall RW, Young T, Shephard B, Desai NS, Barton BA. Morphine pharmacokinetics and pharmacodynamics in preterm and term neonates: secondary results from the NEOPAIN trial. Br J Anaesth. 2008 Nov;101(5):680‐9. Anand KJS, Hall RW. Love, pain and intensive care. Pediatrics 2008 121(4):825‐827. Bergqvist LL, Katz‐Salamon M, Hertegard S, Anand KJ, Lagercrantz H. Mode of delivery modulates pysiological and behavioral responses to neonatal pain. J Perinatol. 2009 Jan;29(1):44‐50. Carbajal R, Rousset A, Danan C, Coquery S, Nolent P, Ducrocq S, Saizou C, Lapillonne A, Granier M, Durand P, Lenclen R, Coursol A, Hubert P, de Saint Blanquat L, Boëlle PY, Annequin D, Cimerman P, Anand KJ, Bréart G. Epidemiology and treatment of painful procedures in neonates in intensive care units. JAMA. 2008 Jul 2;300(1):60‐70. Duncan JM, Meaney P, Simpson P, Berg R, Nadkarni V, Schexnayder SM, National Registry of CPR Investigators. Vasopressin for in‐hospital pediatric cardiac arrest: Results from the American Heart Association National Registry of CPR. Ped Crit Care Med. 2009 Mar;10(2):191‐5. Fiser RT, Morris MC. Extracorporeal Cardiopulmonary Resuscitation in Refractory Pediatric Cardiac Arrest. Pediatr Clin N Am. 2008 Aug; 55(4):929‐941, x. Freer Y, McIntosh N, Teunisse S, Anand, KJ, Boyle EM. More information, less understanding: a randomized study on consent issues in neonatal research. Pediatrics. 2990 May;123(5):326. Heulitt MJ, Jones SM, Holt SJ, Thurman TL, Jo C, Simpson PM. Repeated measurements of respiratory mechanics in developing rats utilizing a forced oscillation technique. Experimental Lung Research 2008 Sep;34(7):409‐23. Kearns GL, Blumer J, Schexnayder S, James LP, Adcock KG, Reed MD, Daniel JF, Gaedigk A, Paul J. Single‐dose pharmacokinetics of oral and intravenous pantoprazole in children and adolescents. J Clin Pharmacol 2008 November; 48(11):1356‐1365. Newth CJ, Venkataraman S, Willson DF, Meert KL, Harrison R, Dean JM, Pollack M, Zimmerman J, Anand KJ, Carcillo JA, Nicholson CE; Eunice Shriver Kennedy National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network. Weaning and estubation readiness in pediatric patients. Pediatr Crit Care Med. 2009 Jan;10(1):1‐11. 37 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Prodhan P, Fiser RT, Cenac S, Bhutta AT, Fontenot E, Moss M, Schexnayder S, Seib P, Chipman C, Weygandt L, Imamura M, Jaquiss RD, Dyamenahalli U. Intrahospital transport of children on extracorporeal membrane oxygenation: Indications, process, interventions, and effectiveness. Pediatr Crit Care Med. 2009 Jul 9. Rovnaghi CR, Garg S, Hall RW, Bhutta AT, Anand KJS. Ketamine analgesia for inflammatory pain in neonatal rats: a factorial randomized trial examining long‐term effects. Behav Brain Funct. 2008 Aug 7; 4:35. Stroud MH, Prodhan P, Moss MM, Anand KJS. Redefining the golden hour in pediatric transport. Pediatr Crit Care Med 2008 July; 9(4):435‐437. Wang J, Gu C, Al‐Chaer ED. Altered behavior and digestive outcomes in adult male rats primed with minimal colon pain as neonates. Behavioral and Brain Functions 2008 July; 4(1):28. Book Chapters Al‐Chaer ED, Weaver SA. Functional Pain Syndromes: Presentation and Pathophysiology. Seattle, WA: IASP Press; 2009. Chapter 20. Early life trauma and chronic pain. Al‐Chaer ED. Biobehavioral Approaches to Pain. New York, NY: Springer; 2009. Chapter 2. The Neuroanatomy of Pain and Pain Pathways. Al‐Chaer ED. Mechanisms of Pain in Peripheral Neuropathy. New York, NY: Springer; 2009. Chapter 2. Visceral Pain. Heulitt MJ, Wolf GK, Arnold JH. Rogers' Textbook of Pediatric Intensive Care. 4th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2008. Chapter 34. Mechanical Ventilation. Schexnayder SM, Khilnani P, Shimizu N, Zaritsky AL. Rogers Textbook of Pediatric Intensive Care. 4 ed. Philadelphia, PA: Lippincott Williams and Williams; 2008. Invasive Procedures. Books Doto F, Zaritsky AL, Schexnayder SM, Kleinman ME, Hazinski MF. Pediatric Emergency Assessment, Recognition, and Stabilization, Instructor Manual. Dallas, TX: American Heart Association; 2008. Ralston M, Hazinski MF, Schexnayder SM, Zartisky AL, Kleinman ME. Pediatric Emergency Assessment, Recognition, and Stabilization, Provider Manual. Dallas, TX: American Heart Association; 2008. Schexnayder SM, Zaritsky AL. Pediatric Resuscitation. Preface. Pediatr Clin North Am.2008 Aug;55(4):xv‐xvi. National Professional Positions (Critical Care Medicine) Editorial/Study Section Activities Al‐Chaer, Elie D. Chair, American Gastroenterological Association abstract review committee on Animal Models of Functional and Motility Disorders for Digestive Disease Week, Editorial Board, 2007‐2008 CUMG/Dean Grant review committee, UAMS, Grant Review, 2005‐present Editor in Chief, International Journal of Women's Health, DOve Press, Editor, 2009‐present 38 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Invited to Evaluation Committee for Program Project Grant, University of Maryland Dental School, Grant Review, 2002‐present NIH Grant Application Review Council: Neural Sciences and Disorders (NSD‐ C), Grant Review, 2007‐present NIH Special Emphasis Panel to review Specialized Centers of Interdisciplinary Research (SCOR) on Sex & Gender Factors Affecting Women's Health (ZRG1 HOP‐U), Grant Review, 2007‐present NIH Study Section: Somatosensory Pain (ZRG1 IFCN‐K), Grant Review, 2005‐present Reviewer's Board for the journal GUT, Editorial Board, 2004‐present Fiser, Debra H. Scientific Advisory Council, Society for Clinical Pediatrics, Editorial Board, 2004‐present Fiser, Richard T. American Academy of Pediatrics Critical Care Medicine Self‐assessment Program "PREP‐ICU", Editorial Board, 2006‐present Co‐Editor, American Academy of Pediatrics Critical Care Medicine Self‐ assessment Program "PREP‐ICU", Editor, 2007‐present Heulitt, Mark J. PCCM Grant Reviewer, Extubation Readiness Protocol Subcommittee, Grant Review, 2005‐present Schexnayder, Stephen Pediatric Commentary, Physician publication of Arkansas Children's Hospital, Editorial Board, 1999‐present Pediatric Critical Care Medicine, Manuscript Review, 2004‐present Other National Professional Positions Al‐Chaer, Elie D. American Gastroenterological Association, Chair, American Gastroenterological Association (AGA) Research Forum on Animal Models of Funcational and Motility Disorders, 2008 ‐ present American Gastroenterological Association, Chair, American Gastroenterological Association abstract review committee on Animal Models of Functional and Motility Disorders, 2007 ‐ present International Foundation for Functional Gastrointestinal Disorders, Consultant, 2004 ‐ present National Institutes of Health, Co‐Chair, NIH Special Emphasis Panel on the Multi‐disciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network, 2008 ‐ present 39 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Fiser, Richard T. Schexnayder, Stephen National Institutes of Health, NIH Special Emphasis Panel on Sepcialized Centers of Interdisciplinary Research (SCOR) on Sex and Gender Factors Affecting Women’s Health, 2007 ‐ present American Academy of Pediatrics, Section of Critical Care, Member, 1991‐ present American Academy of Pediatrics, Critical Care Medicine Section, Member, 1991 ‐ present American Academy of Pediatrics, Emergency Medicine Section, Member, 1991 ‐ present American Heart Association, International Working Group, Emergency Cardiac Care, 2007 ‐ present Honors & Awards (Critical Care Medicine) Al‐Chaer, Elie D. Fiser, Richard T. Green, Jerril W. Heulitt, Mark J. Schexnayder, Stephen Stroud, Michael H. 40 Invited plenary speaker, Title of Talk: "Irritable Bowel Syndrome: A Tale of Sex, Drugs and Pain.", The Institute of Chinese Medicine Forum on IBS, Hong Kong, 2009 Best Doctors in America, 2008 Educator of the Year Award, University of Arkansas for Medical Sciences, 2007 ‐ 2008 Doctor of the Year, Arkansas Children's HospitalMedical Staff, 2008 Dean's Resident Teaching Award Finalist, University of Arkansas for Medical Sciences, 2008 Best Doctors in America, 2009 Best Doctors in America, 2008 Red Sash Award for Excellence in Teaching, University of Arkansas for Medical Sciences, 2008 Silver Telly Award , in the Education Category for the video of Pediatric Emergency Assessment Recognition and Stabilization, American Heart Association, 2008 C. Robert Chambliss Best Paper Award, American Academy of Pediatrics, Section of Tranport Medicine, 2008 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Developmental Pediatrics & Physical Medicine The Section of Developmental‐Behavioral & Rehabilitative Pediatrics has had an exceptional year in the area of competitive funded grants in the training, surveillance and basic research areas. The Maternal Child Health Bureau has funded the Leadership Education in Developmental‐Behavioral Pediatrics (LEDPB) and the Leadership Education in Neurodevelopmental Disabilities (LEND). The Section had success in the Autism Surveillance grant competition from the Center for Disease Control (CDC), a one‐year pilot project. In the basic science area the Section successfully competed for the biomarker in autism, the oxidative stress in individual with autism and nutrition in autism projects from NICHD, DoD and HRSA, respectively. Successful competition for private foundation support was also obtained from the Autism Speak Foundation and the ACH Foundation to develop a multi‐site registry and treatment of oxidative stress in autism, respectively. In the state’s legislative area, faculty members vigorously participated in the Autism Task Force. This task force, which will continue, helped shape the state’s agenda and debate on several issues. Key issues included an insurance mandate to cover necessary and evidence‐based services for children with autism. Additionally, the task force helped create the framework for a Medicaid 1114‐B demonstration wavier, funded by the recently passed tobacco tax. In the education domain, the resident and fellowship training programs continue to thrive. The resident rotation continues to receive high marks, with excellent performance by the residents on exams. The fellowship received a three year approval from the ACGME, with all recommendations easily met. Although the fellowship positions have been funded by ACH in the past, separate funding for these positions is now available through the LEDBP grant. The second year fellow received the prestigious Trainee Travel Award for her scientifically rigorous project presented at SSPR. The Section now has an Endowed Chair, funded by the Rockefeller Charitable Trust, formally named the Rockefeller Chair for Children with Special Health Care Needs. The inaugural chair holder is Professor Eldon G. Schulz Contract and clinic activities are major contributors to the Section’s success. Significant contracts with the States DDS program support several faculty, both within the Section and also in Endocrinology and Infectious Disease. Arkansas Medicaid continues to financially support the large (~60 clinic days/yr) outreach developmental‐rehab clinics around the state. The clinical activity at the Dennis Developmental Center continues to be the primary teaching and clinical service venue for the Section. Faculty recruitment has resumed with the departure of two faculty members this year. Faculty (Developmental Pediatrics & Physical Medicine) Instructor Bailey, Amy Beazley, A. Jane Clinical Attending Clinical Assistant Professor Parmley, Patricia Reid, Tyra M. Clinical Associate Professor Tompkins, Esther H. Clinical Educator Assistant Professor Gargus, Regina A. Lopez, Maya L. 41 Associate Professor Ashcraft, Edmond W. Fussell, Jill J. Shultz, Sam L. Stefans, Vikki A. Professor Schulz, Eldon G. Research Scientist Professor James, S. Jill Research Assistant Professor Melnyk, Stepan B. Annual Report: 2008‐2009 | UAMS Department of Pediatrics Grants (Developmental Pediatrics & Physical Medicine) Primary Investigator/ Project Title Awarded Fussell, Jill MCH Leadership in Developmental and Behavioral Pediatrics Fellowship Training Program Gargus, Gina Toddler behaviors: Parent needs, Community resources ‐AAP Catch James, Jill Autism Treatment Network Proposal Metabolic Biomarkers of Autism: Predictive Potential and Genetic Susceptibility Metabolic Biomarkers of Autism: Predictive Potential and Genetic Susceptibility Ralph Carmel Project: NY Methodist Hospital Ralph Carmel Project: NY Methodist Hospital Redox Abnormalities for Autism Treating Oxidative Stress and the Metabolic Pathology of Autism UA# Autism Interv. Research Network AIR‐P Network Admin Project Schulz, Eldon Arkansas Autism and Developmental Disabilty Monitoring Program (AR ADDM) Leadership Education in Neurodevelopmental and Other Related Disabilities (LEND) Stefans, Vikki A Six Month, Multi‐Center, Open Label Study to assess the Safety and Efficacy of Oral Glycopyrrolate Liquid for the Treatment of Pathologic Drooling in Pediatric Patients 3 to 18 years of age with CP Pending James, Jill "Louisville GSH Study" fee for service agreement Autism, Oxidative Stress, Epigenetic Dysfunction Oxidative Stress and Epigenetic Dysregulation in the Autistic Brain Schulz, Eldon Rural Autism FACTS (Family Support, Assessment in Community, and Therapeutic Services) Not Awarded James, Jill Biomarkers of Oxidative Stress in Autism Funding Agency Agency Award Number HRSA 1 T77MC09798‐01‐00 American Acad. Peds ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect Project Dates Budget Year $103,047 $8,096 $103,047 $8,096 7/1/2008 7/1/2008 6/30/2013 6/30/2009 1824‐2 $7,131 $0 $11,400 $0 1/1/2008 1/1/2008 4/30/2009 4/30/2009 Cure Autism Now 1710‐2 $121,572 $18,236 $243,478 $36,522 1/1/2008 1/1/2008 12/31/2010 12/31/2009 NIH 1 R01 HD051873‐03 $245,743 $93,382 $267,750 $101,745 8/10/2006 6/1/2008 5/31/2011 5/31/2009 NIH 1 R01 HD051873‐04 $136,603 $51,909 $275,471 $104,679 8/10/2006 6/1/2009 5/31/2011 5/31/2010 NIH 1582‐2 $2,572 $977 $20,435 $7,765 10/1/2006 10/1/2006 9/30/2008 9/30/2008 NIH 1582‐4 $818 $385 $3,300 DOD 1762‐2 $98,973 $42,558 $125,000 ACH Fdt. ACH Foundation account 2630*0081 $266,760 $0 $332,811 $0 1/1/2008 1/1/2008 6/30/2010 6/30/2010 DHHS/MCHB 1964‐2 $56,761 $9,650 $68,376 $11,624 9/1/2008 9/1/2008 8/31/2009 8/31/2009 CDC 1 UR3DD000086‐01 $157,740 $40,616 $318,094 $81,906 6/1/2009 6/1/2009 5/31/2010 5/31/2010 HRSA 1 T73MC11045‐01‐00 $425,189 $31,387 $512,191 $37,809 9/1/2008 9/1/2008 8/31/2011 8/31/2009 Omnicare Sc‐GLYCO‐06‐01 $14,537 $3,528 $60,050 $14,575 8/1/2007 8/1/2007 8/1/2008 10/15/2008 University of Louisville Research Foundation 1982‐1 $0 $0 $5,000 $500 1/1/2009 1/1/2009 12/31/2011 12/31/2010 NIH 2030‐1 $0 $0 $304,069 $121,292 10/1/2009 10/1/2009 9/30/2011 9/30/2010 NIH 2049‐1 $0 $0 $303,278 $120,921 10/1/2009 10/1/2009 9/30/2011 9/30/2010 HRSA 2057‐1 $0 $0 $341,861 $58,116 9/1/2009 9/1/2009 8/31/2011 8/31/2010 Autism Speaks 1947‐1 $0 $0 $107,741 $22,191 1/1/2009 1/1/2009 12/31/2009 12/31/2009 $1,551 3/1/2009 3/1/2009 2/28/2011 2/28/2011 $53,750 9/15/2008 9/15/2008 9/14/2011 9/14/2009 Publications (Developmental Pediatrics & Physical Medicine) Journal Articles Blossom SJ, Doss JC, Hennings LJ, Jernigan S, Melnyk S, James SJ. Developmental Exposure to Trichloroethylene Promotes CD4 T cell differentiation and hyperactivity in association with oxidative stress and neurobehavioral deficits in MRL +/+ mice. Toxicol Appl Pharmacol. 2008 Sep 15; 231(3):344‐53. 42 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Celtikci B, Leclerc D, Lawrance AK, Deng L, Friedman HC, Krupenko NI, Krupenko SA, Melnyk S, James SJ, Peterson AC, Rozen R. Altered Expression of Methyltetrahydofolate Reductase Modifies Response to Methotrexate in Mice. Genomics 2008 Jul; 18(7):577‐589. Fussell JJ, Farrar HC, Blaszak R, Sisterhen LL. Incorporating The ACGME Educational Competencies Into Morbidity And Mortality Review Conference. Teach Learn Med 2009 July; 21(3):233‐239. James SJ, Melnyk S, Fuchs G, Reit T, Jernigan S, Pavliv O, Hubanks A, Gaylor DW. Efficacy of Methylcobalamin and Folinic Acid treatment on Glutathione Redox status in children with autism. Am J Clin Nutr 2009 Jan;89(1):425‐430. James SJ, Melnyk S, Jernigan S, Hubanks A, Rose S, Gaylor DW. Abnormal Transmethylation/transsulfuration Metabolism and DNA Hypomethylation Among Parents of Children with Autism. J Autism Dev Disor 2008 10; 38(10):1966‐75. Pogribny I, Karpf A, James S, Melnyk S, Han T, Tryndyak V. Epigenetic alterations in the brains of Fisher 344 rats induced by long‐term administration of folate/methyl‐deficient diet. Brain Res. 2008 Oct 27;1237:25‐34. Pogribny I, Tryndyak V, Boureiko A, Melnyk S, Bagnyukova T, Montgomery B, Rusyn I. Mechanism of peroxisome proliferator‐induced DNA hypomethylation in rat liver. Mutat Res. 2008 Sep 26; 644(1‐2):17‐23. Rose S, Melnyk S, Savenka A, Hubanks A, Jernigan S, Cleves MA, James SJ. The Frequency of Polymorphysms Affecting Lead and Mercury Toxicity among Children with Autism. Amer J Biochem and Biotechnology. 2008; 4(2):85‐ 94 Ulrich CM, Neuhouser M, Liu AY, Boynton A, Gregory JF 3rd, Shane B, James SJ, Reed MC, Mijhout HF. Mathematical modeling of folate metabolism: predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis. Cancer Epidemiol Biomarkers Prev. 2008 Jul; 17(7):1822‐31. Wheeler JG, Taylor JL, Schulz E, Ochoa E. Children's behavioral and mental health: addressing the workforce issues. J Ark Med Soc. 2009 Jun;105(12):280‐281. Whiteside‐Mansell L, Bradley RH, Casey, PH, Fussell JJ, Conners‐Burrow NA. Triple Risk: Do Difficult Temperament and Family Conflict Increase the Likelihood of Behavioral Maladjustment in Children Born Low Birth Weight and Preterm? J Pediatr Psychol. 2009 May;34(4):396‐405. Book Chapters James S. Modulation of Age‐Associated Immune Dysfunction by Nutritional Intervention. New York: Raven Press; Chapter 15. James S. Oxidative Stress and the Metabolic Pathology of Autism. Humana Press; 2008. Current Theories and Evidence. James S. Autism: Current Theories and Evidence. AW Zimmerman, Humana Press ed. New Jersey: AW Zimmerman; 2008. Chapter 11. Oxidative Stress and the Metabolic Pathology of Autism. James SJ. In Principles and Practice of Geriatric Medicine. 2nd ed. England: John Wiley and Sons, Ltd; 2008. 43 Annual Report: 2008‐2009 | UAMS Department of Pediatrics National Professional Positions (Developmental Pediatrics & Physical Medicine) Editorial/Study Section Activities Fussell, Jill American Academy of Pediatrics, Editorial Board for the Developmental‐ Behavioral Pediatrics Review and Education Program (PREP), 2008 – present Developmental‐Behavioral Pediatrics Review & Education Program, Editorial Board, 2008 ‐present Psychology in the Schools journal, Editorial Board, 2006‐present Schulz, Eldon G. Journal of Clinical Pediatrics, Peer Reviewer, 2002 ‐ present Stefans, Vikki A. American Journal of Medicine and Rehabilitation, Associate Editor, 2002 – present American Journal of Physical Medicine and Rehabilitation, Editorial Board, 2004‐present Archives of PM&R, Editorial Board/Reviewer, 1997 ‐ present Tompkins, Esther H. Association of Academic Physiatrists, Peer editor/reviewer for Pediatric PM&R, 2009 ‐ present Other National Professional Positions Fussell, Jill American Academy of Pediatrics, Appointed member of the Committe on Early Childhood, Adoption and Dependant Care , 2007 ‐ present American Academy of Pediatrics, Chairman of the SODBP Membership Committee, 2006 ‐ present American Academy of Pediatrics, Committee Chairperson, 2006 ‐ present American Academy of Pediatrics, elected member of the Executive Committee of the Section of Developmental‐Behavioral Pediatrics (SODBP), 2006 ‐ present National AAP Developmental Behavioral Pediatrics, Executive Committee, 2006 ‐ 2008 Society for Developmental and Behavioral Pediatrics (SDBP), Member of the SDBP Fellowship Communications Subcommittee, 2006 ‐ present Lopez, Maya L. American Academy of Pediatrics, Chapter Child Care Contact, 2008 ‐ present American Academy of Pediatrics, Member, Nominations Committee, Section of Developmental Behavioral Pediatrics, 2008 ‐ 2010 44 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Honors & Awards (Developmental Pediatrics & Physical Medicine) Fussell, Jill Schulz, Eldon G. Tompkins, Esther H. Clinical Director of the Autism Treatment Network in Arkansas, Autism Speaks Nonprofit Organization, 2008 Educator of the Year, UAMS Department of Pedicatrics, 2008 SSPR Young Faculty Award, Southern Society for Pediatric Research, 2008 Rockefeller Endowed Chair for Children with Special Health Care Needs , Rockefeller Charitable Trust, 2008 Voted Best Doctor 2002‐2009, Nations Best Doctors, 2002 ‐ 2009 George Bean, DO Memorial Outstanding Physician Award, Arkansas Ostoepathic Medical Association, 2009 Emergency Medicine This academic year saw several months with record setting patient volumes in the emergency department. In addition to increased patient volume, the acuity of patients, reflected in record numbers of admissions from the emergency department, also grew dramatically. The section implemented several new patient flow strategies in the emergency department, which resulted in stable or lower left without being seen rates in the face of increased volumes. The education efforts of the section continue to grow. The section achieved a full complement of six pediatric emergency medicine fellows this year. The fellowship program was reaccredited by the ACGME for a four year cycle. One of the faculty members, Dr. Kendall Stanford, was awarded the department Educator of the Year award for his outstanding educational efforts. The research work of the section saw increased productivity. Dr. James Graham was co‐investigator on a HRSA EMSC targeted issues grant on ATV injury prevention. In addition, an NIH grant application was submitted for the first time from the section. Several faculty members had either abstracts or papers submitted or published for the first time since joining the faculty, including Drs. David McLario, Becky Latch, Kristen Lyle, and Tonya Thompson. Faculty (Emergency Medicine) Instructor Campion, Laura C. Huckabee, Mary E. Nowell, Rebecca A. Clinical Attending Clinical Assistant Professor Liggin, Rebecca L. Lyle, Kristin Willis, Charlotte R. Clinical Associate Professor Stanford, Kendall L. 45 Clinical Educator Assistant Professor Latch, Rebecca Schexnayder, Rebecca Storm, Elizabeth Thompson, Tonya M. Associate Professor Foster, Donald McLario, David J. Shirm, Steven Vyas, Dileepkumar R. Professor Dick, Rhonda M. Graham, C. James Annual Report: 2008‐2009 | UAMS Department of Pediatrics Grants (Emergency Medicine) Primary Investigator/ Project Title Awarded Thompson, Tonya Incorporation of Emergency Medical Services for Children into Arkansas EMS Pending Graham, James Trial of an Intervention to Reduce Rural Disparities in Pediatric Emergency Health Funding Agency Agency Award Number HRSA 1 H33MC06682‐03 NIH 2029‐1 ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect $68,560 $8,001 $102,981 $0 $0 $323,496 $12,018 Project Dates Budget Year 3/1/2006 3/1/2008 2/28/2009 2/28/2009 $152,043 10/1/2009 10/1/2009 9/30/2011 9/30/2010 Publications (Emergency Medicine) Journal Articles Bowman SM, Aitken ME, Helmkamp JC, Maham SA, Graham CJ. Impact of helmets on injuries to riders of all‐terrain vehicles. Injury Prevention 2009 Feb; 15(1):3 ‐ 7. Thompson TM, Latch R, Parnell D, Dick R, Aitken ME, Graham J. Foot injuries associated with all‐terrain vehicle use in children and adolescents. Pediatr Emerg Care. 2008 Jul;24(7):466‐7. National Professional Positions (Emergency Medicine) Other National Professional Positions Dick, Rhonda M. American Heart Association ‐ Pediatric Advanced Life Support, Affiliate Faculty , 1989 ‐ present American Heart Association ‐ Pediatric Advanced Life Support, Instructor, 1989‐present American Heart Association ‐ Pediatric Advanced Life Support, Medical Director, 1989 ‐ present Honors & Awards (Emergency Medicine) Graham, C. James McLario, David J. Stanford, Kendall L. 46 Red Sash Award for Excellence in Teaching, University of Arkansas for Medical Sciences, 2008 Red Sash Award for Excellence in Teaching, University of Arkansas for Medical Sciences, 2009 Invited Attendee, NIH Roundtable Discussion of Medical and Surgical Emergencies, National Institutes of Health, 2009 ‐ 2009 Rookie (Outstanding New Faculty Member) of the Year, UAMS College of Medicine, 2008 ‐ 2008 Educator of the Year, Department of Pediatrics, 2009 Educator of the Year, Department of Pediatrics, 2008 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Storm, Elizabeth Thompson, Tonya M. ACH Patient Satisfaction Dean's List, University of Arkansas for Medical Sciences, 2008‐2009 Teacher of the Year , Department of Pediatric Graduating Resident Class of 2009 Distinguished Teaching Award, University of Arkansas for Medical Sciences, 2008 Endocrinology & Diabetes The Division of Pediatric Endocrinology and Diabetes has completed and implemented recommendations developed through the outpatient initiative carried out through the auspices of the DOP and ACH. One outcome of this initiative has been to provide additional outpatient clinic availability for children and adolescents with endocrine and diabetes care needs. Another accomplishment of the initiative has been to provide to referring physicians the ability to obtain an appointment date and time for their patients at the time they make a referral through a centralized appointing process. Beyond the ACH clinics, children with endocrine disorders and diabetes are seen in the Centers for Children clinics as an outreach effort to those families and children living in northwest Arkansas. The Division is also using cutting‐ edge technology to help medically manage children with diabetes; the Division has become involved in providing access to a web‐based reporting system for families to record and transmit important patient care data to the diabetes team in order to provide prompt and user‐friendly feedback for diabetes management. The Division continues to offer educational opportunities for medical students and residents, and has an active fellowship training program in Pediatric Endocrinology. The Division remains very active in clinical, translational and basic research. Areas of research include clinical trials in growth hormone and insulin‐like growth factor therapy. Basic science initiatives are also focused in insulin‐like growth factors and how they affect bone formation and bone physiology. New studies are examining how mediators of inflammation may impair the actions of growth promoting factors in bone, and how, in particular, the cytokine TNF‐alpha may cause deleterious effects on the skeleton, as well as mediate the negative effects of alcohol on bone. Ongoing studies are also focusing on how mediators of inflammation may impact macrophages and fat cells, and vice versa. As a participating center in TrialNet, the Division offers families the opportunity to be involved in screening first degree relatives for Type I diabetes risk as well as screening family members for genetic markers linked to diabetes. Studies carried out at ACH in new onset Type 1 diabetics are aimed at understanding if intensive insulin therapy, provided by an insulin pump, can help protect pancreatic beta cells from long‐term damage and thereby help in the preservation of endogenous insulin production. Ongoing studies are examining biomarkers that may identify individuals with Type 1 diabetes who may go on to develop kidney disease, and additional intramural funding has been acquired to study similar markers in animal models of Type 1 diabetes. Recent studies employing proteomic approaches have now identified new and novel markers for early signs of kidney damage in Type 1 diabetes. Finally, several members of the section have now collaborated and are intensively investigating how diabetes impacts the skeleton and how diabetic bone disease evolves. Faculty (Endocrinology & Diabetes) Clinical Educator Assistant Professor Morales, Alba Associate Professor Frindik, J. Paul Clinical Scientist Professor Fowlkes, John L. 47 Kemp, Stephen F. Thrailkill, Kathryn M. Basic Scientist Professor Lumpkin, Charles K. Research Scientist Research Assistant Professor Bunn, R. Clay Annual Report: 2008‐2009 | UAMS Department of Pediatrics Grants (Endocrinology & Diabetes) Primary Investigator/ Project Title Awarded Bunn, Clay Regulation of EFGR Ligand Production by Insulin in Macrophages and Adipocytes Fowlkes, John The physiology of IGFBP‐degrading proteinases in bone Frindik, Paul Increlex Growth Forum Database ‐ IGFD Registry: A Patient Registry for Monitoring Long‐term Safety and Efficacy of Increlex Kemp, Steve A Study of Genotropin in Idiopathic Short Stature Patients: Comparing an Individualized, Target‐driven Treatment Regimen to Standard Dosing of Gentropin A Twelve‐Month, Phase II, Randomized, Open‐Label , Multi‐Center, Dose‐Ranging Study of Weekly ALTU‐238 as Compared with Daily Nutropin AQ in Prepubertal Children with Growth Hormone Deficiency Genentech National Cooperative Growth Study (NCGS) Post Marketing Surveillance Program for Nutropin AQ, Nutropin and Protropin. Noonan Study Norditropin National Registry Recombinant Human Insulin‐Like Growth Factor‐1 Treatment of Children and Adolescents with growth failure associated with primary IGF‐1 Deficiencey: An Open‐Label, Multicenter, Extension Study The Global Hpopituitary Control and Complications Study Lumpkin, Chuck Ethanol and Osteoblastogenesis: Roles of IL‐1 and TNF Ethanol and Osteoblastogenesis: Roles of IL‐1 and TNF Thrailkill, Kathryn A Phase 2/3, Randomized, Double‐Blind, Multicenter, Multinational, 4‐Arm, Controlled, Dose‐Ranging Study to Evaluate Efficacy and Safety of Teplizumab in Children and Adults with Recent‐Onset Type I Diabetes Mellitus Safety and Efficacy of Exubera Compared with Subcutaneous Human Insulin Therapy in Children and Adolescents ages 6 ‐ 17 years with type 1 DM The Natural History Study of the Development of Type 1 Diabetes Type 1 Diabetes Genetics Consortium‐ North American Regional Network Pending Bunn, Clay Mechanisms of Inflammatory Activation of Peripheral Blood Monocytes by Insulin and Metabolic Stress Fowlkes, John Skeletal Modeling in Type 1 and Type 2 Diabetes Lumpkin, Chuck Aging & Skeletal Regeneration: Comparative Therapeutics Not Awarded Fowlkes, John The Insulin/IGF‐I Axis in Diabetic Osteopathy Lumpkin, Chuck Ethanol and Osteoblastogenesis: Roles of IL‐1 and TNF Thrailkill, Kathryn Matrix Metalloproteinases and Diabetic Nephropathy 48 Funding Agency Agency Award Number Lyon Award 1274‐2 NIH/NIDDK 5 R01 DK055653‐09 Tercica MS305 Pfizer ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect Project Dates Budget Year $7,188 $0 $50,000 $0 7/1/2005 7/1/2005 12/31/2008 12/31/2008 $176,551 $67,089 $176,551 $67,089 9/1/2005 7/1/2008 6/30/2010 6/30/2009 $5,373 $1,343 $16,133 $4,034 10/16/2007 10/16/2007 10/15/2010 10/15/2010 A6281280 $27,234 $6,650 $75,360 $18,403 3/28/2007 3/28/2007 12/31/2009 12/31/2009 Altus 0001194 $15,569 $4,671 $61,846 $18,554 1/12/2009 1/12/2009 12/31/2010 12/31/2010 Genentech 85‐036 $11,142 $542 $250,896 $12,200 Insmed 1691‐2 $8 $2 $3,000 $750 6/1/2007 7/1/2008 6/1/2007 7/1/2008 NovoNordisk NNR $400 $100 $2,800 $700 5/1/2003 5/1/2010 5/1/2003 5/1/2010 Tercica MS306 $16,298 $4,074 $16,320 $4,080 1/1/2008 1/1/2010 1/1/2008 1/1/2010 Eli Lilly B9R‐MC‐GDGA $8,066 $1,913 $71,956 $17,064 11/1/2002 11/1/2002 9/30/2011 9/30/2011 NIH/NIAAA 5R01AA012223‐08 $142,357 $54,096 $189,636 $72,062 7/20/2005 4/1/2008 3/31/2010 3/31/2009 NIH/NIAAA 5R01AA012223‐09 $94,039 $35,735 $189,636 $72,062 7/20/2005 4/1/2009 3/31/2010 3/31/2010 Parexel MGA031 $20,950 $5,238 $83,917 Icon A2171083 $225 $56 $5,220 $1,305 10/31/2007 10/31/2007 7/31/2008 7/11/2008 TrialNet U01‐DK61055 $11,389 $2,847 $62,000 $15,500 1/21/2005 1/21/2005 1/31/2010 6/30/2010 BRI Site 4053 $380 $95 $1,200 NIH 1990‐1 $0 $0 $200,000 $94,000 12/1/2009 12/1/2009 11/30/2014 11/30/2010 NIH 2035‐1 $0 $0 $277,682 $127,947 9/30/2009 9/30/2009 9/29/2011 9/29/2010 NIH/NIAAA 2016‐1 $0 $0 $250,000 $117,500 2/1/2010 2/1/2010 1/31/2012 1/31/2011 NIH/NIDDK 1938‐1 $0 $0 $250,000 $117,500 7/1/2009 7/1/2009 6/30/2014 6/30/2010 NIH/NIAAA 5R01AA012223‐08 $0 $0 $250,000 $117,500 12/1/2009 12/1/2009 11/30/2014 11/30/2010 NIH/NIDDK 954‐11 $0 $0 $410,083 $186,629 12/1/2009 12/1/2009 11/30/2014 11/30/2010 Annual Report: 2008‐2009 | UAMS Department of Pediatrics $20,979 $300 7/1/1989 7/1/1989 12/31/2011 12/31/2011 2/6/2009 2/6/2009 1/31/2011 1/31/2011 7/5/2006 7/5/2006 8/31/2009 8/31/2009 Publications (Endocrinology & Diabetes) Journal Articles Kemp SF. Insulin‐like Growth Factor‐1 Deficiency in Children with Growth Hormone Insensitivity: Current and Future Treatment Options. Biodrugs 2009 March; 23(3):155‐163. Thrailkill K, Nimmo, T, Bunn, R.C, Cockrell, G.E, Moreau, C.S, Mackintosh, S, Edmondson, R.D, Fowlkes, J. Microalbuminuria in type 1 diabetes mellitus (T1DM) is associated with enhanced excretion of the endocytic, multiligand receptors megalin and cublilin. Diabetes Care. 2009 Jul;32(7):1266‐8. Thrailkill KM, Bunn RC, Fowlkes JL. Matrix Metalloproteinases: Their potential role in the pathogenesis of diabetic nephropathy. Endocrine 2009 February; 35(1):1‐10. Wahl EC, Aronson J, Liu L, Fowlkes JL, Thrailkill KM, Bunn RC, Skinner RA, Miller MJ, Cockrell GE, Clark LM, Ou Y, Isales CM, Badger TM, Ronis MJ, Sims J, Lumpkin CK. Restoration of regenerative osteoblastogenesis in aged mice: modulation of TNF. J Bone Miner Res. 2009 Jul 6. National Professional Positions (Endocrinology & Diabetes) Editorial/Study Section Activities Fowlkes, John L. NIH Challenge Grant reviewer (MOSS), 2009 Kemp, Stephen F. Chief Editor, Endocrinology Chapters. The Pediatric On‐Line Reference., Editor, 2008‐present Other National Professional Positions Kemp, Stephen F. KABI International Growth Studay (KIGS), Advisory, US Board and International Board, 2006 ‐ 2009 National Cooperative Growth Studay (NCGS), Advisor, 1992 ‐ 2008 Thrailkill, Kathryn M. Lawson Wilkins Pediatric Endocrine Society, Committee Member, 2007 ‐ 2008 Honors & Awards (Endocrinology & Diabetes) Kemp, Stephen F. 49 Best Doctors in America, 2008 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Gastroenterology, Hepatology & Nutrition The Gastroenterology, Hepatology and Nutrition Section provides outpatient clinics for Gastroenterology, Intestinal Rehabilitation and Transplant Hepatology. The Section was the first to be evaluated by the Outpatient Initiative (OPI) which examined physician efficiency in clinics, clinic utilization, clinic scheduling and patient satisfaction scores to optimize current clinic availability. After implementation of the recommendations by the OPI, the service saw a 31.9% increase in outpatient visits in FY09 and GI procedures increased by 61% from 772 to 1,246. The increases also overflowed into the inpatient side with a 21% increase in inpatient consults (221 to 321). Advances in the clinical area include an application to conduct liver transplantation which was submitted to UNOS and is currently under review with approval pending. The Autism Specialty Clinic (ASC) with UAMS Chief of GI as Medical Director was established in 2009 to provide specialty diagnostic and treatment services for children with autism spectrum disorders (ASD). The pediatric specialty services represented in the clinic include Gastroenterology and Nutrition, Genetics, Neurology, and Sleep Disorders and enable a child with ASD and their family to be seen by more than one service in a single visit. Section faculty are active in multiple research projects and had 21 publications during FY09. In the past year, new avenues of research were investigated on the complex relationship between dietary composition, caloric intake and obesity in the young. Using dietary manipulations and precise control of caloric input, a viable animal model for pediatric obesity was developed to investigate the underlying mechanisms of altered hepatic metabolism, insulin resistance and increased adiposity in the young. Another developing research area is that of intestinal rehabilitation. Also, the relationship between H. pylori infection and iron status was defined. Faculty (Gastroenterology, Hepatology & Nutrition) Clinical Scientist Professor Fuchs, III, George J. Basic Scientist Assistant Professor Andres, Aline Shankar, Kartik Research Scientist Research Assistant Professor Chen, Jin‐Ran Gilchrist, Janet M. Research Professor Pivik, R. Terry Instructor Marecki, John C. Clinical Attending Clinical Assistant Professor Corredor‐Buchmann, Julissa Clinical Educator Assistant Professor Frem, Juliana C. Gibbons, Troy E. Associate Professor O'Connor, Judith Grants (Gastroenterology, Hepatology & Nutrition) Primary Investigator/ Project Title Awarded Andres, Aline Developing Normative Body Domposition Data in Early Infancy Fuchs, III, George An Efficacy and Safety Study of Reslizumab in the Treatment of Eosinophilic Esophagitis in Subjects Aged 5 to 18 years of age An Open‐Label Safety and Efficacy Study of Reslizumab for the Treatment of Pediatric Subjects with Eosinophilic Esophagitis Who Completed Study RES‐5‐0002 50 Funding Agency Agency Award Number Life Measurement 1471‐2 Ception Ception ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect Budget Year $7,095 $1,668 $39,795 Res‐5‐0002 $28,511 $8,226 $45,750 $13,200 2/22/2008 2/22/2008 1/31/2009 1/31/2009 RES‐5‐0004 $47,416 $11,533 $64,536 $15,696 7/11/2008 7/11/2008 6/30/2010 6/30/2010 Annual Report: 2008‐2009 | UAMS Department of Pediatrics $9,353 Project Dates 3/6/2006 3/6/2006 12/31/2008 12/31/2008 Primary Investigator/ Project Title Not Awarded Chen, Jin‐Ran Estrogen‐Independent Effects of Soy Consumption on Bone Formation Fuchs, III, George A Study of Sleep Disturbance and Gastrointestinal Disease in Children with Autism A Study of Sleep Disturbance and Gastrointestinal Disease in Children with Autism Spectrum Disorder O'Connor, Judy Childrens U01 Funding Agency Agency Award Number ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect Project Dates Budget Year NIH 1940‐1 $0 $0 $250,000 $107,500 7/1/2009 7/1/2009 6/30/2014 6/30/2010 Autism Speaks 1968‐1 $0 $0 $68,182 $6,818 1/1/2009 1/1/2009 12/31/2012 12/31/2009 NIH 2052‐1 $0 $0 $123,519 $57,020 7/1/2009 7/1/2009 6/30/2011 6/30/2010 NIH 1960‐1 $0 $0 $82,900 $38,963 1/1/2009 1/1/2009 12/31/2013 12/31/2010 Publications (Gastroenterology, Hepatology & Nutrition) Journal Articles Badger TM, Gilchrist JM, Pivik RT, Andres A, Shankar K, Chen JR, Ronis MJJ. The health implications of soy infant formula. Am. J Clin. Nutr. 2009 89(1668S‐1672S) Badger TM, Ronis MJ, Wolff GL, Stanley JS, Ferguson ME, Shankar K, Simpson PM, Jo CH. Soy Protein Isolate Reduces Hepatosteatosis in Yellow Avy/a Mice Without Altering Coat Color Phenotype. Exp Biol Med (Maywood). 2008 Oct; 233(10):1242‐1254. Baumgardner JN, Shankar K, Hennings L, Albano E, Badger TM, Ronis MJ. N‐acetylcysteine attenuates progression of liver pathology in a rat model of nonalcoholic steatohepatitis. J Nutr 2008 Oct; 138(10):1872‐1879. Corredor J, Troy E. Gibbons, Chandra Smith. Placement of pH Probe during Upper Endoscopy: Direct Visualization is accurate. The Journal of Arkansas Medical Society 2009 Feb.; 105(8):183‐6. James SJ, Melnyk S, Fuchs G, Reit T, Jernigan S, Pavliv O, Hubanks A, Gaylor DW. Efficacy of Methylcobalamin and Folinic Acid treatment on Glutathione Redox status in children with autism. Am J Clin Nutr 2009 Jan;89(1):425‐430. Sarker SA, Davidsson L, Mahmud H, Fuchs G, Alam NH, Ahmed T. Casual relationship of Helicobacter pylori infection with iron deficiency anemia and treatment failure of iron supplementation in children. Gastroenterology. 2008 Nov;135(5):1534‐42. Shankar K, Singhal R, Badger TM, Ronis MJ. Hepatic gene expression following consumption of soy protein isolate in female Sprague‐Dawley rats differs from that produced by 17‐estradiol treatment. J. Endocrinol. 2009 202:141‐152. Su Y, Shankar K, Simmen RCM. Early soy exposure via maternal diet regulates rat mammary epithelial differentiation by paracrine signaling from stromal adipocytes. J Nutr. 2009 139:945‐951. Book Chapters Fuchs G. Fluid and electrolytes. Koletzko B (ed). Karger, Basel: 2008; 52‐6. Honors & Awards (Gastroenterology, Hepatology & Nutrition) O'Connor, Judith 51 Best Doctors in America, 2008 Best Doctors in America, 2009 Annual Report: 2008‐2009 | UAMS Department of Pediatrics General Pediatrics The General Pediatric Section once again had an excellent year. Clinically increasing numbers of patients are seen in the General Pediatric Clinic, Continuity Clinic, Fitness Clinic, Asthma Clinic and Headache Clinic. This year saw the start of the Pediatric Diagnostic Clinic which has served as an entry point for patients who need a second opinion or the physician is not sure which specialist the patient should see or when the next available appointment for a subspecialty service is more than 2 weeks. There3 have been 390 patient visits since its inception. The clinic continues to grow and has received very positive feedback from referring physicians. The Hospitalist Service covered all but 18 weeks of the inpatient service, and starting next year all general ward teams will be covered by a hospitalist. The section continues to play a significant role in the education of medical students and residents. The Outpatient Morning Report has been enhances to include a WEB CT course and a more structured curriculum. General Pediatrics is proud to have three Red Sash Winners for excellence in teaching in the section. On the research side, the Section has continued involvement in the area of clinical trials. There are at least two trials ongoing at any time. A QI program has also been instituted; the first being an attempt to identify patients who have missed scheduled immunizations and to develop a system to ensure they receive needed vaccine. Faculty have worked closely with the health department to develop an accurate, accessible record that combines information in the ACH system with information in the Health Department system, which could be a model for all practices. Faculty (General Pediatrics) Haynes, Lisa Lal, Arti Razzaq, Samiya Sisterhen, Laura L. Tanios, Aline T. Associate Professor Baldwin, Ronald L. Dildy, Dale W. Elser, Joseph M. Magee, James S. Ochoa, Eduardo R. Smith, Christopher E. Young, Karen L. Instructor Bass, Lanessa D. Patil, Sowmya N. Clinical Attending Clinical Assistant Professor Becton, Debra McLeane, Laura R. Simmons, A. Larry Clinical Associate Professor Diokno, Rosana M. Clinical Educator Assistant Professor Baldwin, Shelly L. Brown, Carrie M. Grants (General Pediatrics) Primary Investigator/ Project Title Awarded Elser, Joe A Phase II, Randomized, Double‐Blind, Placebo‐Controlled Study to Evaluate a Single IM Dose of Motavizumab, a Humanized Enhanced Potency Monoclonal Antibody Against RSV, for the Outpatient Treatment of Children with RSV illness. A Phase III, Randomized, Multi‐national Study, Double‐Blinded for the immunogenicity and Consistency Evaluation of 3 Hib‐MedCY‐TT Vaccine Lots and Single‐Blinded and Controlled for the evaluation of Safety and Immunogenicity of GSK Biologicals haemophilus A Randomized, Multicenter, Placebo‐Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of a Combination Product Containing Sumatriptan and Naproxen Sodium for the Acute Treatment of Migraine in Adolescents 52 Funding Agency Agency Award Number MedImmune MI‐CP146 GlaxoSmithKline GlaxoSmithKline ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect Project Dates Budget Year $9,363 $2,272 $59,904 $14,539 2/15/2007 2/15/2007 2/15/2008 10/1/2008 Hib‐Men‐CY‐TT‐ 103813 $22,461 $5,584 $316,661 $78,728 4/24/2006 4/24/2006 8/30/2008 8/30/2008 TXA107979 $37,133 $11,140 $76,201 $22,860 12/17/2008 12/17/2008 2/22/2010 2/22/2010 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Primary Investigator/ Project Title Comparative Gastrointestinal Tolerance of Various Infant Formulas in Healthy Term Infants The Evaluation of Cow Milk‐Based Formulas‐ Study B Funding Agency Agency Award Number Abbott AK54 Mead Johnson MJ‐3378 ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect Project Dates Budget Year $9,005 $2,251 $13,600 $3,400 10/31/2008 10/31/2008 11/1/2009 11/1/2009 $26,442 $6,249 $31,980 $7,558 9/8/2008 9/8/2008 8/31/2009 8/31/2009 Publications (General Pediatrics) Journal Articles Baldwin S. Considerations for the medical evaluation of international adoptees. J Ark Med Soc. 2008 Nov;105(5):112‐ 4. Fussell JJ, Farrar HC, Blaszak R, Sisterhen LL. Incorporating The ACGME Educational Competencies Into Morbidity And Mortality Review Conference. Teach Learn Med 2009 July; 21(3):233‐239. Gonzalez‐Espada W, Hall‐Barrow J, Hall RW, Burke B, Smith CE. Peds PLACE: Quality Continuing Medical Education in Arkansas. Journal of the Arkansas Medical Society 2009 March; 105(9):211‐213. Gonzalez‐Espada W, Hall‐Barrow J, Hall RW, Burke B, Smith CE. Peds PLACE: Quality Continuing Medical Education in Arkansas. Journal of the Arkansas Medical Society 2009 March; 105(9):211‐213. Gonzalez‐Espada WJ, Hall‐Barrow J, Hall RW, Burke BL, Smith CE. Achieving Success Connecting Academic and Practicing Clinicians Through Telemedicine. Pediatrics 2009 Mar;123(3):e484‐e491. Hopkins R, Kennedy J, Magee J, Perry T. Adolescent and adult asthma: Guidelines for stepwise treatment. J Ark Med Soc 2008 December; 105(6):132‐133. Sisterhen LL. A Paradox in Physician Health. J Ark Med Soc 2008 November; 105(5):101. Sisterhen LL. Need for a Statewide Trauma System. J Ark Med Soc 2009 April; 105(10):220. Tanios AT, Lyle RE, Casey PH. ACH Medical Home Program for Special Needs Chidren. A New Medical Era. J Ark Med Soc. 2009 Jan; 105(7):163‐5. Wheeler JG, Taylor JL, Schulz E, Ochoa E. Children's behavioral and mental health: addressing the workforce issues. J Ark Med Soc. 2009 Jun;105(12):280‐281. Book Chapters Ward‐Begnoche WL, Pasold T, O'Neill VS, Peck D, Razzaq S, Young K. Treating Obesity Across the Lifespan. Springer Press; 2008. Chapter 1. Childhood Obesity Treatment Literature Review. National Professional Positions (General Pediatrics) Editorial/Study Section Activities Sisterhen, Laura L. Journal of Arkansas Medical Societ, Editorial Board, 2008‐2009 53 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Smith, Christopher E. Academic Pediatric Association, Educational Workshop Reviewer, 2005 ‐ 2009 Academic Pediatric Association, Miller‐Sarkin Award Reviewer, 2006 ‐ 2008 Academic Pediatric Association, Scientific Abstract Reviewer, 1993 ‐ 2009 Other National Professional Positions Sisterhen, Laura L. Academic Pediatric Association, Pediatric Tobacco Issues Special Interest Group, 2008 ‐ present American Academy of Pediatrics‐Fellow, Section on Hospital Medicine, 2007 ‐ present American Public Health Association, Section on Maternal and Child Health, 2006 ‐ 2008 Smith, Christopher E. Academic Pediatric Association Education Committee, 1993 ‐ 2009 Association of American Medical Colleges, Group on Educational Affairs(GEA), 1993 ‐ 2009 Association of American Medical Colleges, Group on Resident Affairs (GRA), 1993 ‐ 2009 Association of American Medical Colleges, Participant, Invitational Concensus Conference on Electronic Portfolios, 2007 ‐ present Young, Karen L. Academic Pediatric Association, Obesity Special Interest Group ‐ founding group member, 2004 ‐ present American Academy of Pediatrics, Arkansas Chapter of AAP, Committee on Childhood Overweight, 2003 ‐ present American Academy of Pediatrics, Nutrition Section, 2004 ‐ present Obesity Special Interest Group, Executive Committee, 2008 ‐ present Honors & Awards (General Pediatrics) Baldwin, Shelly L. Elser, Joseph M. 54 Teacher of the Year, University of Arkansas for Medical Sciences, College of Medicine, 2008 Teamwork Award, Arkansas Children's Hospital, 4C Nursing Staff, 2008 Dean's List (September‐November), College of Medicine, University of Arkansas for Medical Sciences, 2008 Red Sash Award for Excellence in Teaching, University of Arkansas for Medical Sciences, 2009 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Magee, James S. Ochoa, Eduardo R. Simmons, A. Larry Smith, Christopher E. Runner‐Up ‐ Best Faculty Teacher on Junior Medical Student Pediatric Clerkship (2007‐2008), University of Arkansas for Medical Sciences, 2008 Mejor de lo Mejor (Best of the Best) Physicians, Selected by readers of El Latino, Central Arkansas Spanish weekly newspapaer, 2008 Best Doctors in America, 2009 Red Sash Award for Excellence in Teaching, University of Arkansas for Medical Sciences, 2008 ACH Patient Satisfaction Dean's List, University of Arkansas for Medical Sciences, College of Medicine, 2009 ACH Patient Satisfaction Dean's List, University of Arkansas for Medical Sciences, College of Medicine, 2008 Tanios, Aline T. 55 Red Sash Award for Excellence in Teaching, University of Arkansas for Medical Sciences, 2009 Master Teacher Award, in recognition of longstanding, superior contributions to medical education in the College of Medicine, University of Arkansas for Medical Sciences, 2009 Best Doctors in America, 2009 Best Doctors in America, 2008 Red Sash Award for Excellence in Teaching, University of Arkansas for Medical Sciences, 2009 ACH Patient Satisfaction Dean's List, University of Arkansas for Medical Sciences, 2008 Crossing the Creek Award, Arkansas Children's Hospital, 2009 Teamwork Award‐Continuation of Medical Home Program, Arkansas Children's Hospital, 2008 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Genetics & Metabolism FY09 was an exciting year for genetics and metabolism in Arkansas. Two major events both occurred on July 1, 2008 when Dr. Brad Schaefer began work as the new section head of Genetics and Metabolism and advanced newborn screening began in Arkansas. The section has quickly grown adding two genetic counselors, one advanced practice nurse and a newborn screening coordinator. Additional staff has allowed the expansion of clinical services. The section added / participated in several new clinics including additional general genetics clinics, metabolic follow‐up clinic, Down syndrome specialty clinic, dystrophinopathy clinic and an interdisciplinary autism clinic. The first outreach clinic at the Centers for Children in Lowell has been planned for next year. Increased staff has also allowed for increased participation in teaching activities. Section members have been part of Pediatric Grand Rounds, resident teaching lectures and resident board review sessions. Dr. Schaefer’s research into the genetic basis of autism resulted in several publications in FY09 and presentations at multiple national meetings including the AAP NCE meeting in 2008. In addition, his lab is now up and running and is continuing studies using quantitative neuro‐imaging of brain changes in neurogenetic conditions and premature infants. Particularly important has been the roll out of advanced newborn screening in Arkansas. This major undertaking has happened smoothly with major collaborations between the section of genetics and metabolism, ACH labs and the Department of Health. The program has been a huge success in identifying children with life‐threatening disorders prior to onset of illness. With the addition of new faculty member Dr. Dolf Garnica, joining Dr. Schaefer and Dr. Steve Kahler, the Genetics program is the largest in the history of the DOP. Faculty (Genetics & Metabolism) Clinical Attending Clinical Associate Professor Garnica, Adolfo D. Clinical Educator Professor Kahler, Stephen G. Schaefer, G. Bradley Publications (Genetics & Metabolism) Journal Articles Arnold GL, Koeberl DD, Matern D, Barshop B, Braverman N, Burton B, Cederbaum S, Fiegenbaum A, Garganta C, Gibson J, Goodman SI, Harding C, Kahler S, Kronn D, Longo N. A Delphi‐based consensus clinical practice protocol for the diagnosis and management of Schaefer GB. Advances in clinical genetics. Part IV. Introduction. Semin Pediatr Neurol. 2008 Sep;15(3):109. Stamm DS, Aylsworth AS, Stajich JM, Kahler SG, Thorne LB, Speer MC, Powell CM. Native American myopathy: congenital myopathy with cleft palate, skeletal anomalies, and susceptibility to malignant hyperthermia. Am J Med Genet A 2008 Jul 15; 146A(14):1832‐41 Stamm DS, Powell CM, Stajich JM, Zismann VL, Stephan DA, Chesnut B, Aylsworth AS, Kahler SG, Deak KL, Gilbert JR, Speer MC/ Novel congenital myopathy locus identified in Native American Indians at 12q13.13‐14.1. Neurology. 2008 Nov 25;71(22):1764‐9 56 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Book Chapters Bodensteiner JB, Ellis CR, Schaefer GB. Current Management in Child Neurology. London: BC Decker, Inc; 2009. Chapter 46. Mental Retardation. National Professional Positions (Genetics & Metabolism) Editorial/Study Section Activities Schaefer, G. Bradley Expert Reviewer, National Library of Medicine. Genetics Home Reference. http://ghr.nlm.nih.gov/, Editorial Board, 2006‐present Guest Editor, Seminars in Pediatric Neurology, Neurogenetics ‐ 4 part series Part 4. Neuro‐metabolic Conditions, Editor, September 2008 Invited Reviewer, NIH / National Institute of Nursing Research, Grant Review, 2001‐present J. Child. Neurol. Editorial Board: 1995 – Present Honors & Awards (Genetics & Metabolism) Schaefer, G. Bradley Alpha Omega Alpha, Member Arkansas Chapter, 2008 Committee for the Future Endowed Chair, Genetics, Arkansas Children's Hospital, 2008 Hobart E. Wiltse, M.D., Ph.D. Excellence in Medical Education Award, University of Nebraska Medical Center, Department of Pediatrics, 2008 Reagents Appointed Endowed Chair: Munroe‐Meyer/Scottish Rite Masonic Professor of Child Health, 2008 Hematology & Oncology The Pediatric Hematology & Oncology service has had a productive year. Clinical programs have continued to grow, with over 100 newly diagnosed oncology patients again this year, from all corners of the state. Over 90% of all children and adolescents with cancer in Arkansas are diagnosed and treated at ACH. There are specialized comprehensive areas within the Oncology Program for Bone Tumors, working with an Orthopedic Oncologist, and Brain Tumors, working with the Pediatric Neurosurgeons and UAMS CARTI. The Sickle Cell Program has continued to flourish, offering comprehensive visits as well as acute care visits for painful crises and other acute illnesses associated with Sickle Cell diseases. Of particular interest is the active hematocytopheresis program for sickle cell patients with stroke or recurrent acute chest syndrome, currently managing over 20 patients with these complications on a monthly red cell pheresis program. There has been significant growth in the Comprehensive Bleeding Disorders and Thrombosis Center, for the evaluation and management of this growing group of patients. 57 Annual Report: 2008‐2009 | UAMS Department of Pediatrics The Pediatric Hematology & Oncology fellowship program has been approved, and in the Spring of 2009 participated in the fellowship match program for the first time with the successful recruitment of the first fellow who will start in July, 2010. Overall education endeavors have been acknowledged by two Red Sash award winners for excellence in teaching in the section this year, as well as acknowledgement by medical students and residents in evaluations. Research endeavors include federally funded oncology clinical trials through the Children's Oncology Group (NCI); locally funded clinical trials investigating biomarkers in febrile neutropenic cancer patients (CUMG); federally funded Sickle Cell research into long‐term evaluation of patients at risk for CVA (NHLBI); federally funded research into the long‐term complications and manifestations of hemophilia (CDC/MCHB); and industry sponsored trials in Hemophilia products and supportive care in oncology patients. Section faculty published five journal articles, five abstracts and had two poster presentations in FY09. Faculty (Hematology & Oncology) Clinical Attending Clinical Assistant Professor Saccente, Suzanne Clinical Educator Assistant Professor Mian, Amir R. Clinical Scientist Associate Professor Saylors, Robert L. Professor Becton, David L. Stine, Kimo C. Grants (Hematology & Oncology) Primary Investigator/ Project Title Awarded Becton, David COG Chair Grant 08‐09 Admin COG Chair Grant 08‐09 Per Case Reimbursement Payment COG Chair Grant 09‐10 Admin COG Chair Grant 09‐10 PCR account Saccente, Suzanne Silent Cerebral Infarct Transfusion Saylors, Bob A 3 Month Prospective Open Label Study of Therapy with Fragmin in Children with Malignancies and Venous Thromboembolism A Double‐Blind Randomized Stratified Multi‐Center Trial Evaluating Conventional and High Dose Oseltamivir in the Treatment of Immunocompromised Patients with Influenza PHO 07‐17 A Phase III, Open‐Label, Single‐Arm Study of Tenecteplase for Restoration of Function in Dysfunctional Central Venous Access Catheters PHO 08‐09 International randomized study to evaluate the addition of docetaxel (Taxotere) to the combination of cisplatin‐5‐fluorouracil (TCF) vs. cisplatin‐5‐fluoruracil (CF) in the induction treatment of nasopharyngeal carcinoma (NPC) in child & Adls. Stine, Kimo A Phase II Trial of Perifosine in Patients with Chemo‐Insensitive Sarcomas A study to determine the activity of SCH717454 in subjects with osteosarcoma or Ewing's sarcoma that has relapsed after standard systemic therapy An Open Label Study Evaluating the Safety and Efficacy of Long‐Term Dosing of AMG 531 in Thrombocytopenic subjects with ITP 58 Funding Agency Agency Award Number NIH 109‐26 $15,529 $3,106 $23,325 $4,665 3/1/2008 3/1/2008 2/28/2009 2/28/2009 NIH U10CA98543‐01 Agreement 98543‐ 1017 $44,362 $6,655 $66,634 $9,996 3/1/2008 3/1/2008 2/28/2009 2/28/2009 NIH 109‐32 $11,858 $2,371 $23,913 $4,782 3/1/2009 3/1/2009 2/28/2010 2/28/2010 NIH 109‐34 $12,505 $1,876 $25,217 $3,783 3/1/2009 3/1/2009 2/28/2010 2/28/2010 NIH 973‐4 $1,654 $235 $20,730 $2,945 9/1/2003 9/1/2003 11/30/2010 11/30/2008 EISAI FRAG‐A001‐201 $15,901 $4,770 $32,153 $9,646 1/30/2009 1/30/2009 1/30/2010 1/30/2010 Roche NV20234 $36,425 $8,799 $51,962 Genentech N3699g $11,885 $2,837 $38,666 Sanofi EFC10339 $133,848 $33,060 $145,834 SARC SARC‐007 $6,374 $1,429 $16,950 $3,800 11/15/2007 11/15/2007 11/15/2008 11/15/2008 Schering‐Plough SCH717454 $20,749 $4,858 $27,590 $6,460 7/1/2008 7/1/2008 6/30/2010 6/30/2010 Amgen AMG 531 20030213 $21,531 $5,127 $36,862 $8,778 4/2/2008 4/2/2008 3/31/2011 3/31/2011 Annual Report: 2008‐2009 | UAMS Department of Pediatrics ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect $12,553 Project Dates Budget Year 4/1/2008 4/1/2008 9/30/2010 9/30/2010 $9,229 7/20/2007 7/20/2007 12/1/2008 12/1/2008 $36,021 6/1/2008 6/1/2008 5/31/2009 5/31/2009 Primary Investigator/ Project Title Funding Agency Agency Award Number ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect PASS‐INT‐003: A Prospecitve, Open, Uncontrolled Surveillance of SURgical Interventions with FEIBA (SURF) PHO 05‐10 A Prospective, Randomized, Cross‐Over Study of an Activated Prothrombin Complex Concentrate for Secondary Prophylaxis in Patients with Hemophilia A and Inibitors (PRO‐FEIBA) PHO 07‐31: A Randomized, Double‐Blind, Placebo‐Controlled Phase 1/2 Study to Determine the Safety and Efficacy of AMG531 in Thrombocytopenic Pediatric Subjects with Chronic Immune Thrombocytopenic Purpura PHO 10‐01 A Phase 4 Study to Determine the Pharmocokinetic Response of Patients Diagnosed with Severe Hemophilia A to Different Doses of Advate fACF‐PFM Prevention of the Complications of Hemophilia Through Hemophilia Treatment Centers (subcontract with UT) Prevention of the Complications of Hemophilia Through Hemophilia Treatment Centers (subcontract with UT) Prospective Advate ITI Registry ‐ PAIR Randomized, Controlled, Parallel, Prospective Trial to Evaluate the Effect of Secondary Prophylaxis with rFVIII Therapy in Severe Hemophilia A Adult Subjects Compared to that of episodic treatment (SPINART) Region VI Comprehensive Hemophilia Program (AR Site/subcontract with UT) Region VI Comprehensive Hemophilia Program (AR Site/subcontract with UT) SARC 009: A Phase II Trial of Dasatinib in Advanced Sarcoma Pending Becton, David COG Chair Grant 09‐10 PCR account Stine, Kimo CHAVI 014 Not Awarded Stine, Kimo Data Management Funding Baxter PASS‐INT‐003 $3,833 $706 $6,658 $1,227 11/6/2007 11/6/2007 7/31/2009 7/31/2009 Tulane PRO‐FEIBA $8,287 $1,908 $29,720 $6,843 8/30/2006 8/30/2006 3/30/2010 3/30/2010 Amgen 20060195‐11 $13,757 $3,439 $31,754 $7,939 12/6/2007 12/6/2007 12/6/2008 12/6/2008 Baxter 060403 $5,946 $1,174 $51,150 CDC U27/CCU61318‐‐11 $15,116 $2,267 $60,797 $9,119 9/30/2001 9/30/2007 9/29/2008 9/29/2008 CDC U27/CCU61318‐‐12 $45,639 $6,845 $60,797 $9,119 9/30/2001 9/30/2008 9/29/2009 9/29/2009 Baxter PAIR $7,329 $1,832 $22,028 $5,507 1/27/2007 1/27/2007 1/27/2010 1/27/2010 PPD SPINART $10,038 $2,296 $20,588 $4,709 7/11/2008 7/11/2008 6/30/2011 6/30/2011 MCHB 5 H30 MC 00029 $37,650 $5,270 $41,022 $5,742 6/1/2002 6/1/2008 5/31/2009 5/31/2009 MCHB 5 H30 MC 00029 $20,342 $2,847 $41,022 $5,742 6/1/2002 6/1/2009 5/31/2010 5/31/2010 Bristol Meyers SARC009 $4,243 $973 $21,250 $4,875 9/20/2007 9/20/2007 9/20/2012 9/20/2012 NIH 109‐33 $0 $0 $25,217 $3,783 3/1/2009 3/1/2009 2/28/2010 2/28/2010 NIH 1983‐1 $0 $0 $5,554 $2,435 7/1/2009 7/1/2009 6/30/2010 6/30/2010 American Thrombosis & Hemostasis Network 1923‐1 $0 $0 $50,337 $10,100 Project Dates Budget Year 9/1/2006 9/1/2006 9/1/2007 9/26/2008 $4,027 11/1/2008 11/1/2008 10/31/2009 10/31/2009 Publications (Hematology & Oncology) Journal Articles Jeha S, Razzouk B, Rytting M, Rheingold S, Albano E, Kadota R, Luchtman‐Jones L, Bomgaars L, Gaynon P, Goldman S, Ritchey K, Arceci R, Altman A, Stine K, Steinherz L, Steinherz P. Phase II Study of Clofarabine in Pediatric Patients with Refractory or Relapsed Acute Myeloid Leukemia. J Clin Oncol. 2009 Aug 3. Mian A, Becton D, Blackall DP, James SH, Berman DM, Owusu JA, Turner C, Givner LB, Shetty AK. Index of Suspicion. Pediatr Rev. 2009 Apr;30(4):139‐45. Nicholas RW, Stine K. Sarcomas of the Bone in Children, Adolescents, and young Adults. . Pediatric Commentary 2008 Summer; 17(2):16‐17. Stine K, Becton DL. Bleeding Disorders: When is normal bleeding not normal? 2009 Jul; 106(2):40‐42. 59 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Honors & Awards (Hematology & Oncology) Becton, David L. Saylors, Robert L. Red Sash Award for Excellence in Teaching, University of Arkansas for Medical Sciences, 2009 Red Sash Award for Excellence in Teaching, University of Arkansas for Medical Sciences, 2009 Infectious Diseases Fiscal year 2008‐2009 has been a transitional and dynamic year for the Pediatric Infectious Diseases Section. The Section’s new Chief, Dr. José R. Romero arrived in July. An additional faculty member, Dr. Matthew Linam, was recruited and will start in August of 2009. This will bring the compliment of physicians in the Section to five. An additional Specialty Nurse joined the Section in May 2009 to assist in the care of the growing number of patients seen by the Section. The Section continues to participate in NIH‐sponsored trials and has been a leader in the enrollment of patients in these clinical trials. Additionally, the Section was selected as a site for the conduct of several diagnostic and vaccine trials that will begin in late FY09 and early FY10. Two Section members received a Red Sash Award for excellence in teaching at this year’s graduation event. Dr. Romero was appointed to the National Board of Medical Examiners Step 1 Question Writing Panel. Dr. Richard Jacobs was named Chairman of the American Board of Pediatrics’ Sub‐Board of Infectious Diseases The Section successfully graduated its Infectious Disease Fellow, Jessica Nichols. Additionally, the Section recruited a new fellow, Dr. Kathy Liverett, to begin training in a Pediatric Infectious Diseases/Adult Infectious Diseases Fellowship. This will be the first time the Section has undertaken combined training with the Adult Infectious Diseases fellowship program and is first combined Pediatric/Adult Fellowship established in the University of Arkansas for Medical Sciences. The Section was successful in securing additional clinic space, allowing for outpatient activities to increase. Outpatient activities have expanded and transitioned from a single clinic session per week to three sessions per week. Future plans are to expand to five sessions per week. Dr. Stephanie Stovall was appointed as a member of the Extracorporeal Life Support Organization. Dr. Gary Wheeler has continued his work in International Health recently completing a two week trip to Belize to work on Public Health infrastructure. Dr. Romero was appointed alternate chair for FDA site visit of Intermural Research of the Laboratory of Retroviruses, Laboratory of Immunoregulation and Laboratory of Respiratory Viruses. The members of the Section published a total of six peer‐reviewed articles, two invited reviews, and 12 book chapters for in FY09. Additionally, Section members gave one international, three national, seven regional and four Section‐sponsored presentations for the same time period. Faculty (Infectious Diseases) Clinical Educator Assistant Professor Stovall, Stephanie H. Associate Professor Abernathy, Rosalind S. Professor Romero, Jose R. Wheeler, J. Gary 60 Clinical Scientist Assistant Professor Harik, Nada S. Basic Scientist Assistant Professor Nagarajan, Uma M. Annual Report: 2008‐2009 | UAMS Department of Pediatrics Grants (Infectious Diseases) Primary Investigator/ Project Title Awarded Nagarajan, Uma Molecular mechanisms of Chlamydia‐induced type I interferon response Molecular mechanisms of Chlamydia‐induced type I interferon response Romero, Jose A Double Blind, Placebo Controlled Virologic Efficacy Trial of Pleconaril in the Treatment of Neonates with Enteroviral Sepsis Syndrome A Pharmacokinetic/Pharmacodynamic and Safety evaluation of Oseltamivir for the Treatment of Children Less than 24 months of Age with Confirmed Influenza Infection A Phase 1/2a, Randomized, Double‐Blind, Placebo‐Controlled, Dose Escalation Study to Evaluate the Safety, Tolerability, Immunogenicity and Vaccine‐like Viral Shedding of MEDI‐534 A Phase I/II Pharmacokinetic and Pharmacodynamic Evaluation of Oral Valganciclovir in Neonates with Symptomatic Congenital Cytomegalovirus (CMV) Infection involving the Central Nervous System CASG 112: A Phase II Randomized, Placebo‐Controlled Blinded Investigation of Six Weeks vx. Six Months of Oral Valganciclovia Therapy in Infants with Symptomatic Congential Cytomegalovirus Infections. Clinical Performance Evaluation of the 3M Rapid Detection RSV Test from Patients with Suspected RSV Infections (Left over Samples) Stovall, Stephanie International Pediatric Fungal Network (PFN) Database Meropenem Yearly Susceptibility Test information Collection Multicenter Pneumococcal Surveillance Study Funding Agency Agency Award Number ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect Project Dates Budget Year NIH R01 AI067678‐02A2 $202,583 $87,111 $220,725 $94,912 6/3/2007 6/1/2008 5/31/2012 5/31/2009 NIH R01 AI067678‐03 $109,455 $47,066 $220,725 $94,912 6/3/2007 6/1/2009 5/31/2012 5/31/2010 UAB CASG 106 $599 $12 $7,840 $160 7/1/1997 7/1/1997 7/31/2010 7/31/2010 UAB CASG #114 $40,236 $10,059 $140,880 MedImmune MI‐CP178 $9,447 $2,834 $18,842 $5,653 5/5/2009 5/5/2009 4/30/2010 4/30/2010 UAB CASG 109 $7,448 $190 $97,512 $2,488 7/1/1997 7/1/1997 7/31/2010 7/31/2010 UAB CASG 112 $79,617 $30,255 $110,362 $41,938 7/1/2008 7/1/2008 7/31/2010 7/31/2010 3M CSP‐015 $49,102 $14,731 $57,408 $17,222 12/12/2008 12/12/2008 11/30/2009 8/3/2009 Duke 00003641 $799 $200 $4,000 $1,000 12/1/2007 12/1/2007 11/30/2012 11/30/2012 Jones Group 2002 Mystic $201 $50 $2,800 $700 Texas Childrens Hospital 932‐2 $1,016 $254 $16,360 $4,090 $35,220 1/31/2007 1/31/2007 7/31/2010 7/31/2010 1/1/2002 1/1/2002 12/31/2008 12/31/2008 7/1/1993 8/1/2009 7/1/1993 8/1/2009 Publications (Infectious Diseases) Journal Articles Dees SC, Harrison GM, Abernathy RS. The use of an orally administered combination of rapid and prolonged acting bronchodilator in asthmatic children A clinical study of Nephenalin. Annals of Allergy 1953; 11:297‐300. Gill WP, Harik NS, Whiddon M, Mittler JE, Sherman DR. A Novel Replication Clock for Mycobacterium tuberculosis. Nature Medicine 2009 Feb; 15(2):211‐4. Nagarajan UM, Prantner D , Sikes JD, Andrews CW Jr, Goodwin AD, Nagarajan S, Darville T. Type I interferon signaling exacerbates Chlamydia muridarum genital infection in a murine model. Infect Immun. 2008 Oct; 76(10):4642‐8. O'Brien C, Harik N, James L, Seib P, Stowe C. Cesium‐Induced QT‐Interval Prolongation in an Adolescent. Pharmacotherapy 2008 August; 28(8):1059‐65. Prantner D, Nagarajan UM. Role of the Chlamydial type III secretion apparatus in host cytokine expression. Infect Immun. 2009 Jan;77(1):76‐84. Romero JR, Simonsen KA. Powassan Encephalitis and Colorado Tick Fever. Infect Dis Clin North Am. 2008 Sep;22(3):545‐59, x. 61 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Romero JR. Pediatric Group B Coxsackievirus Infections. Curr Top Microbiol Immunol 2008 323:223‐240. Sheffer CE, Stitzer M, Payne TJ, Applegate BW, Bourne D, Wheeler JG. Treatment for Tobacco Dependence for Rural, Lower‐Income Smokers: Outcomes, Predictors, and Measurement Considerations. Am J Health Promot. 2009 May‐ Jun;23(5):328‐38 Varman MV, Romero JR, Cusick RA, Esposito PW, Armstrong D. Polymicrobial wound infection and nerve injury secondary to a non‐human primate bite. Infect Med 2008 25:120‐127. Wheeler J, Pulley L, Bursac Z, Stewart M K, Mays G P, Mackey D S. Making Hospital Grounds Smoke‐Free: A Case Study of Arkansas Act 134 of 2005. J Public Health Manag Pract. 2009 Mar‐Apr;15(2):E9‐15. Wheeler JG, Taylor JL, Schulz E, Ochoa E. Children's behavioral and mental health: addressing the workforce issues. J Ark Med Soc. 2009 Jun;105(12):280‐281. Book Chapters Harik N, Jacobs RF. Textbook of Pediatric Infectious Disease, 6th edition. Feigin RD, Cherry JD ed. Philadelphia, Pennsylvania: WB Saunders Co; 2009. Chapter 110. Nocardia, pp 1504‐1508. Newland JG, Romero JR. Neurologic Manifestations of Pediatric Infectious and Immunologic Diseases. New York: Humana Press.; 2008. Myxoviruses. Newland JG, Romero JR. The Encyclopedia of Public Health. Academic Press ed. San Diego: 2008. Enteroviruses. Romero JR, Varman M, Barton L. Neurologic Manifestations of Pediatric Infectious and Immunologic Diseases. New York: Humana Press.; 2008. Togaviruses. Romero JR. Antimicrobial Therapy and Vaccines, Volume II. Enteroviruses (Coxsackieviruses, Echoviruses and Numbered Enteroviruses) and Parechoviruses. Romero JR. Neurologic Manifestations of Pediatric Infectious and Immunologic Diseases. New York: Humana Press.; 2008. Arboviruses. Romero JR. Neurologic Manifestations of Pediatric Infectious and Immunologic Diseases. New York: Humana Press.; 2008. Orthopoxviruses. Stovall SH, Schutze GE. Textbook of Pediatric Infectious Diseases. 6 ed. June 2009. Blastomycosis. Wheeler J, Abramson JS, Quie P. Immunologic disorders in infants and children. 3rd ed. The Polymorphonuclear phagocytic system. Wheeler JG, Jacobs RF. Textbook of Pediatric Infectious Disease, 6th edition. Feigin RD, Cherry JD ed. Philadelphia, Pennsylvania: WB Saunders Co; 2009. Chapter 29. Pleural Effusions and Empyema, pp 325‐335. Wheeler JG, Jacobs RF. Textbook of Pediatric Infectious Disease, 6th edition. Feigin RD, Cherry JD ed. Philadelphia, Pennsylvania: WB Saunders Co; 2009. Chapter 30. Lung Abscess, pp 336‐342. 62 Annual Report: 2008‐2009 | UAMS Department of Pediatrics National Professional Positions (Infectious Diseases) Editorial/Study Section Activities Nagarajan, Uma M. CUMG intramural grants, Grant Review, 2008 Special Emphasis Panel 2 for RFA AI‐08‐005‐ "Development of novel interventions and tools for the control of malaria, neglected tropical diseases and their vectors,” Grant Review, 2008 Romero, Jose R. Alternate Chair‐Site Visit Laboratories of Retroviruses, Immunoregluation and Respiratory Viruses.FDA Laboratory Research Program ReviewOffice of Vaccines Research and ReviewFood and Drug Administration, Center for Biologic Evaluation and Research, Grant Review, 2009‐2009 Special Emphasis Grant Review Panel: Incidence & Etiology of Influenza Associated Pneumoniae in Hospitalized Persons (IP09‐001) Virologic Evaluation of the Modes of Influenza Virus Transmission Among Humans (IP09‐003), Centers for Disease Control and Prevention, Atlanta, GA, Grant Review, 2009‐2009 Honors & Awards (Infectious Diseases) Romero, Jose R. Stovall, Stephanie H. Wheeler, J. Gary 63 Alpha Omega Alpha National Honor Society, Life Member, 2003 – present American Pediatric Society, elected member, 2009 Best Doctors in America, 2008 Best Doctors in America, 2009 Horace C. Cabe Professor of Pediatrics Endowed Chair, Arkansas Children's Hosp, 2008 Nominated for the Hobart E. Wiltse, M.D., Ph.D. Excellence in Medical Education Award, Nebraska/Creighton Universities Joint Pediatric Residency Program, 2008 Outstanding Academic Faculty Member Teaching Award, Pediatric Residency Program, Creighton/Nebraska Universities Health Foundation, 2008 Best Doctor's in America, 2008 Best Doctors in America, 2008 Best Doctors in America, 2009 Clinical Infectious Diseases Award for Outstanding Review, Clinical Infectious Diseases, 2008 Julius B. Richmond Center of Excellence Award for tobacco cessation, American Academy of Pediatrics, 2008 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Paul Harris Fellow, The Rotary Foundation of Rotary International, 2009 Red Sash Award for Excellence in Teaching, University of Arkansas for Medical Sciences, 2008 Smoke Free Champion, The Smoke Free Project, 2008 Neonatology The Neonatology section had an outstanding FY 09 year in the areas of clinical care, education, research, and administration. Important clinical highlights included the move to the new University Hospital NICU with 65 private rooms, each with accommodations for parents. This has resulted in a greater emphasis on family centered care and enhanced parental satisfaction. Coupled with the 85 bed NICU at ACH, the total of 150 available NICU beds makes the UAMS Neonatal‐ Perinatal training program the largest in the United States. The section cares for approximately 1,900 NICU admissions yearly. The Medical Home Clinic for Special Needs Children has continued to expand its efforts to coordinate care for medically complex children, especially NICU graduates with severe bronchopulmonary dysplasia, genetic disorders and major birth defects which required surgery. The clinic is co‐directed by Dr. Rob Lyle and follows over 400 of the state’s most vulnerable infants, providing seamless medical care across multiple disciplines. This concept has resulted in excellent outcomes for medically fragile infants, better access to subspecialty care and cost savings for insurers and families. The program was recently awarded 3rd place in the Child Health Corporation of America Race for Results competition among the nation’s leading children’s hospitals, recognizing new and innovative models of care and quality improvement initiatives. The High Risk Newborn Clinic can now focus on follow up care of over 900 less complex NICU graduates. The State Outreach/Education Program has been greatly enhanced through a novel telemedicine program which allows immediate visual communication from UAMS and ACH NICU’s to 24 nurseries across Arkansas. These nurseries care for most deliveries in the state outside the Little Rock area. Since the establishment of this program, the state’s neonatal and infant mortality rates have decreased, attesting to the importance of outreach efforts by the section. The Section had a banner year for its educational efforts. Following ACGME review, the Section’s Neonatal‐Perinatal Medicine Fellowship program received the maximum five year accreditation cycle and was approved for expansion to two fellowship positions at each year of training (six total positions). The Section continues to have a 100% subspecialty board pass rate among graduates of its fellowship program. PedsPlace, an interactive telemedicine outreach program with a noon conference each Thursday, was established through an NIH supplemental grant to the section. This program has been highly successful with community clinicians and has resulted in several national presentations and publications. Dr. Bryan Burke, who co‐moderates PedsPlace, recently joined ACH and KARK television station in Little Rock to present a weekly TV spot highlighting a topic in pediatric care to a statewide audience. Three Section members received the Red Sash Award for excellence in teaching from the medical school class of 2009. Dr. Bobby McGehee received the prestigious Gold Sash Award. Research funding and publications have increased over the last year. Recent funding includes two RO‐1 grants, one to Dr. Jeffrey R. Kaiser to study physiologic disturbances associated with intraventricular hemorrhage in extremely low birth weight neonates and another to Dr. Bobby McGehee to study interventions on fat metabolism at the cellular level. 64 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Dr. Billy Thomas received funding to support the Office of Diversity Affairs, including an American Recovery and Reinvestment Act grant to the Center to Reduce Cancer Health Disparities (CRCHD) and Arkansas Cancer Community Network (AR‐CCN) to fund summer research internships for two years. He and Dr. McGehee received a four year award of $1.8M from the National Institute of General Medical Sciences toward an “Initiative to Maximize Student Diversity” in Arkansas. Additionally, collaborative NIH studies to assess the genetic predisposition to intraventricular hemorrhage as well as two pharmacological studies are ongoing. The Section’s telemedicine efforts received a Center for Medicare and Medicaid Services grant for $1.47M to study the effects of a telemedicine initiative on referral patterns and outcomes of very low birth weight babies in the state. Also, two sizable NIH supplemental grants have financed telemedicine units across Arkansas and will be used to study the effects of telemedicine on neonatal outcomes. Dr. Whit Hall will serve as project PI for an NIH COBRE grant to study stress relief from Kangaroo Care and will provide medical directorship of the Community Based Research and Education Core of the recently funded COBRE grant. Dr. Hall also received a Mayday Foundation Grant to study the effects of an electro acupuncture device intended to provide pain relief in neonates. The Section published extensively the last year with over 20 publications in peer reviewed journals. Section members continue to fill important administrative positions at UAMS and ACH. Dr. Bobby McGehee is Dean of the Graduate School, Dr. Billy Thomas is Associate Dean for Diversity Affairs, and Dr. Bonnie Taylor is Associate Dean for Children’s Affairs and Medical Director at ACH. Dr. Donnal Walter is Chief Medical Information Officer at ACH and Dr. Whit Hall has served as Chief of the Medical Staff at ACH for the past two years. With the need for more protected research/administration time among several faculty members and the loss of Dr. Greg Franklin to his “dream job” in Colorado Springs, the section successfully recruited three neonatologists who are completing fellowship training June 30, 2009: Dr. Vivienne Yap from Weill Cornell Medical Center, Dr. Francesca Miguel‐Verges from Johns Hopkins University and Dr. Douglas Seglem from UAMS. Thereby remaining fully staffed, the section’s faculty will continue to cover seven attending teams daily and provide in‐house night call at both ACH and UAMS. Faculty (Neonatology) Instructor Braswell, Erica France Makhijani, Neelam A. Marotti, Tonya May‐Wewers, Julie S. Nesmith, Clare Campbell Clinical Attending Clinical Assistant Professor Esquivel, Maria Teresa Clinical Associate Professor Franklin, Gregory A. Clinical Educator Assistant Professor El‐Hassan, Nahed O. Lightburn, Marla Harrison Monnikendam, Christopher S. Palmer, Kristine G. Prince, Audra M. Ross, Ashley S. Associate Professor Burke, Bryan L. Walter, Donnal C. Clinical Associate Professor Rogers, Becky J. Professor Arrington, Robert W. Hall, R. Whit Lyle, Robert E. Thomas, Billy R. Clinical Scientist Associate Professor Kaiser, Jeffrey R. Szabo, Joanne S. Professor Taylor, Bonnie J. Basic Scientist Professor McGehee, Jr., Robert E. 65 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Grants (Neonatology) Primary Investigator/ Project Title Awarded Kaiser, Jeff Cool Cap Follow‐up Study Gene Targets for IVH (incoming subc from Yale) Physiological Disturbances Associated with Neonatal Intraventricular Hemorrhage Physiological Disturbances Associated with Neonatal Intraventricular Hemorrhage McGehee, Jr., Bobby Mechanisms Underlying Metabolic Syndrome in Obesity Mechanisms Underlying Metabolic Syndrome in Obesity Ross, Ashley Fluconazole Prophylaxis for the Prevention of Candidiasis in Infants <750 grams Birth Weight Thomas, Billy A Prospective, Non‐Interventional Study to Evaluate the Incidence of Hospitalizations and Medically Attended Lower Respirator Tract Infection in Premature Infants 32 to 35 weeks Gestational age that are not recommended to receive prophylaxsis for RSV Feeding Study in Premature Infants, Project No. 3379‐1 to evaluate weight gain of premature infants fed breast milk fortified with either a powder or liquid human milk fortifier Museum of Discovery and CDH: Interactive Telemedicine‐Based Education for Arkansas' Hospitalized Children The University of Arkansas for Medical Sciences Initiative for Maximizing Student Diversity (IMSD) Program Pending Kaiser, Jeff Gene Targets for IVH (incoming subc from Yale) Physiological Disturbances Associated with Neonatal Intraventricular Hemorrhage Physiological Disturbances Associated with Neonatal Intraventricular Hemorrhage McGehee, Jr., Bobby Mechanisms Underlying Metabolic Syndrome In Obesity Mechanisms Underlying Metabolic Syndrome in Obesity Thomas, Billy Administrative Supplement to the University of Arkansas for Medical Sciences Initiative for Maximizing Student Diversity. Not Awarded Hobbs, Charlotte Centers for Birth Defects Research and Prevention 1 Month Cost Extension Request Szabo, Joanne Dietary Sugars in Low Birth Weight Preterm and Term Infants Funding Agency Agency Award Number Olympic 413‐990‐G NIH/NINDS 5 R01 NS053865‐02 NIH/NINDS ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect Project Dates Budget Year $720 $180 $1,440 $360 9/1/2007 9/1/2007 4/30/2009 4/30/2009 $5,566 $2,338 $6,064 $2,547 6/1/2007 6/1/2008 5/31/2012 5/31/2009 1 R01 NS060674‐ 01A1 $358,055 $116,867 $390,120 $127,333 6/1/2008 6/1/2008 5/31/2013 5/31/2009 NIH/NINDS 5 R01 NS060674‐02 $164,896 $69,864 $332,525 $140,886 6/1/2008 6/1/2009 5/31/2013 5/31/2010 NIH/NIDDK 5 R01 DK071277‐04 $128,743 $33,473 $162,318 $42,203 6/1/2005 6/1/2008 5/31/2010 5/31/2010 NIH/NIDDK 5 R01 DK071346‐04 $73,701 $30,954 $92,922 $39,027 6/1/2005 6/1/2008 5/31/2010 5/31/2010 Duke Fluconazole Site 141 $212 $100 $2,600 $1,222 6/16/2009 6/16/2009 12/16/2009 12/16/2009 MedImmune MI‐MA140 $6,178 $1,463 $47,300 $11,200 10/21/2006 10/21/2006 10/31/2007 10/1/2008 Mead Johnson Proj. No. 3379‐1 $4,579 $1,145 $27,703 $6,926 2/24/2009 2/24/2009 2/23/2012 2/23/2012 AT&T N/A $9,839 $2,558 $19,841 $5,159 NIH/NIGMS 1 R25 GM083247‐ 01A1 $117,046 $7,953 $228,273 NIH/NINDS 30894‐3 $0 $0 $5,980 $2,631 NIH/NINDS S2 $0 $0 $142,580 $6,534 NIH/NINDS S2 $0 $0 $114,343 $8,234 6/1/2008 9/1/2009 5/31/2013 8/31/2010 NIH/NIDDK 35937‐1 $0 $0 $22,029 $9,913 6/1/2009 6/1/2009 5/31/2010 5/31/2010 NIH/NIDDK 35952‐1 $0 $0 $34,904 $15,707 6/10/2009 6/10/2009 5/30/2013 5/30/2010 NIH/NIGMS 36359‐1 $0 $0 $175,289 $6,823 9/30/2009 9/30/2009 9/30/2011 9/30/2010 CDC 1929‐2 $0 $0 $43,077 $13,509 11/30/2008 11/30/2008 12/31/2008 12/31/2008 NIH 1942‐1 $0 $0 $293,255 1/1/2009 1/1/2009 12/31/2009 12/31/2009 $15,510 2/13/2009 2/13/2009 1/31/2013 1/31/2010 $112,711 6/1/2007 6/1/2009 5/31/2012 5/31/2010 6/1/2008 6/1/2009 5/31/2013 5/31/2010 7/1/2009 7/1/2009 6/30/2014 6/30/2010 Publications (Neonatology) Journal Articles Anand KJS, Anderson BJ, Holford NHG, Hall RW, Young T, Shephard B, Desai NS, Barton BA. Morphine pharmacokinetics and pharmacodynamics in preterm and term neonates: secondary results from the NEOPAIN trial. Br J Anaesth. 2008 Nov;101(5):680‐9. 66 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Anand KJS, Hall RW. Love, pain and intensive care. Pediatrics 2008 121(4):825‐827. Bhutta AT, Rovnaghi CR, Hall RW, Anand KJS. The effect of ketamine after inflammatory pain on the newborn rat model. J Neuroimmunol 2008 Burgos AE, Burke B. Neonatal Abstinence Syndrome. NeoReviews 2009 May; 10(5):e222 ‐ e229. Burke B, Bynum, Carol A, Hall‐Barrow, Julie, Ott, Rachel, Albright, Margaret. Rural School‐based Telehealth: How to Make it Happen. Clinical Pediatrics 2008 November; 47(9):926‐929. Burke BL, Robbins JM, Bird TM, Hobbs CA, Nesmith C, Tilford JM. Trends in hospitalizations for neonatal jaundice and kernicterus in the United States: 1998 to 2005. Pediatrics 2009 Feb; 123(2):524‐32. ElHassan NO, Jones LR, Ray RM, Rogers BJ, Kaiser JR. A Neonate with Microphthamia and Median Clefting of the Lower Lip and Mandible. Am J Perinatology 2008; 25(1):01‐04. Fujii AM, Bailey J, Doros G, Sampat K, Sikes NC, Mason MJ, Kaiser JR. Effects of beractant and poractant administration on cerebral hemodynamics. J Neonatal Perinatol Med 2009 2(1):27‐34. Gonzalez‐Espada W, Hall‐Barrow J, Hall RW, Burke B, Smith CE. Peds PLACE: Quality Continuing Medical Education in Arkansas. Journal of the Arkansas Medical Society 2009 March; 105(9):211‐213. Gonzalez‐Espada WJ, Hall‐Barrow J, Hall RW, Burke BL, Smith CE. Achieving Success Connecting Academic and Practicing Clinicians Through Telemedicine. Pediatrics 2009 Mar;123(3):e484‐e491. Hall RW, Shbarou RM. Drugs of choice for sedation and analgesia in the neonatal ICU. Clin Perinatol. 2009 Jun;36(2):215‐26, vii. Hall RW, Shbarou RM. Drugs of choice for sedation and analgesia in the neonatal ICU. Clin Perinatol. 2009 Mar;36(1):15‐26. Lightburn MH, Gauss CH, Williams DK, Kaiser JR. Cerebral blood flow velocities in extremely low birth weight infants with hypotension and infants with normal blood pressure. J Pediatr 2009 154:824‐828. Rovnaghi CR, Garg S, Hall RW, Bhutta AT, Anand KJS. Ketamine analgesia for inflammatory pain in neonatal rats: a factorial randomized trial examining long‐term effects. Behav Brain Funct. 2008 Aug 7; 4:35. Tanios AT, Lyle RE, Casey PH. ACH Medical Home Program for Special Needs Chidren. A New Medical Era. J Ark Med Soc. 2009 Jan; 105(7):163‐5. Tuzcu V, Nas S, Ulusar U, Ugur A, Kaiser JR. Altered Heart Rhythm Dynamics in Very Low Birth Weight Infants with Impending Intraventricular Hemorrhage. Pediatrics 2009 123:810‐815. Yao‐Borengasser A, Rasouli N, Varma V, Bodles AM, Unal R, Phanavanh B, Ranganathan G, McGehee Jr. RE, Kern PA. Stearoyl‐CoA desaturase 1(SCD1) gene expression increases following pioglitazone treatment and is associated with PPAR‐gamma responsiveness. J Clin Endocrinol Metab. 2008 Nov;93(11:4431‐9. Book Chapters Kaiser JR. Hot Topics in Neonatal Neurology. 1 ed. New York: Nova Scientific Publishling; 2008. Chapter 5. Neurological Sequelae following Mechanical Ventilation. 67 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Patents (Neonatology) Applied Lyle, Robert E UAMS Invention Disclosure No. 2009‐03 Bilisuit, a garment designed to provide phototherapy to infants with hyperbilirubinemia 2008‐37 Prenatal and Postnatal Maternal‐to‐Infant Transfer of Critical Monosaccharides for Neuologic Development and Immunologic Function Szabo, Joanne S National Professional Positions (Neonatology) Editorial/Study Section Activities Burke, Bryan L. Invited Guest Editor, Pediatric Annals, issue devoted to Tele‐Medicine, Editor, 2009‐present Hall, R. Whit NIH, Reviewer for the LRP, University of Arkansas for Medical Sciences, Grant Review, 2005‐present McGehee, Jr., Robert AAS Competitive Review Committee for Michigan Technology Tri‐Corridor Fund, Grant Review, 2005‐present External Reviewer Committee, Genome Canada Program Project Grants, Grant Review, 2005‐present National Space Biomedical Research Institute, Member, Board of Directors, Grant Review, 2004‐present NIH, INBRE Review Panel, Grant Review, 2004‐present NIH Special Emphasis Study Sections (3), Independent , Grant Review, 2009‐ present Regular Member, NIH‐ Center for Scientific Review, NIDDK‐NRSA F30 and F32 Study Section. Robert Wellner, Scientific Review Administrator, Grant Review, 2009‐present Regular Member, NIH, Center for Scientific Review, Cellular Aspects of Diabetes and Obesity (CADO) Study Section. Ann A. Jerkins, Scientific Review Administrator , Grant Review, 2006‐2009 Standing Member 2005, Ann A. Jerkins, Scientific Review Administrator, NIH, Center for Scientific Review, Cellular Aspects of Diabetes and Obesity (CADO), Grant Review, 2005‐present Standing Member 2006 , Ann A. Jerkins, Scientific Review Administrator, NIH, Center for Scientific Review, Cellular Aspects of Diabetes and Obesity (CADO), Grant Review, 2006‐present 68 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Standing Member 2007, Ann A. Jerkings, Scientific Review Administrator, NIH, Center for Scientific Review, Cellular Aspects of Diabetes and Obesity (CADO), Grant Review, 2007‐present Standing Member 2008, Ann A. Jerkings, Scientific Review Administrator, NIH, Center for Scientific Review, Cellular Aspects of Diabetes and Obesity (CADO), Grant Review, 2008‐present The Adipocyte: An International Journal, Editorial Board, 2009‐present Thomas, Billy R. Health Resources and Services Adminstration Grant Reviewer. , Grant Review, 2004‐present Other National Professional Positions Burke, Bryan L. American Telemedicine Association, 3rd Annual Pediatric Telehealth Colloquium Education Coordinator and Organizer, 2008 Honors & Awards (Neonatology) Arrington, Robert W. Burke, Bryan L. Lyle, Robert E. McGehee, Jr., Robert Monnikendam, Christopher 69 Ruth Olive Beall Award, Arkansas Children's Hospital, 2008 Circle of Excellence Dean's List, University of Arkansas for Medical Sciences, 2009 Faculty Member of the Year for the Pediatric Junior Student Clerkship, Department of Pediatrics, 2008 Red Sash Award for Excellence in Teaching, University of Arkansas for Medical Sciences, 2009 Race for Results Award (recognizing innovative programs in health care delivery), 3rd Place, ACH Medical Home Program for Special Needs Children, Child Health Corporation of America (CHCA), 2009 ACH Patient Satisfaction Dean's List, University of Arkansas for Medical Sciences, 2008 Best Doctors in America, 2008 Best Doctors in America, 2009 Gold Sash Award, University of Arkansas for Medical Sciences, College of Medicine Senior Class Faculty Honor, 2009 Red Sash Award for Excellence in Teaching, University of Arkansas for Medical Sciences, 2009 Dean's List ‐ Circle of Excellence, University of Arkansas for Medical Sciences, 2008 – 2009 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Nephrology The Pediatric Nephrology section continues to be a very active section clinically. A new Pediatric Nephrology clinic has opened at the Centers for Children in northwest Arkansas. This clinic sees Pediatric Nephrology patients in an all day clinic every other month and is moving to a clinic every month due to patient demand. In addition, a separate Pediatric Hypertension clinic was officially established to help streamline the care of children with high blood pressure. The four Nephrology and Hypertension clinics have been the highest in Press‐Ganey scores for ACG clinics for two of the last four quarters. The ambulatory blood pressure monitoring program also remains busy with an increase of approximately 30% over the last year. The Centers for Medicare and Medicaid Services have developed new conditions of participation for dialysis and transplantation and the Section has been active in developing policies and procedures to meet these conditions. The renal transplant program underwent two unannounced on‐site surveys by CMS in the last year and just received a three year approval from CMS. The Section is particularly active in studies relating to pediatric hypertension. Dr. Karen McNiece has been asked to serve as a consultant for several antihypertensive studies conducted through the Pediatric Pharmacology Research Unit NIH grant and now participates regularly in their national meetings. She has also joined the Delta Obesity Prevention Research Unit which is funded by the USDA to study the physical activity patterns and health status of residents in the Delta region. In the past year, Dr. McNiece was also named as a finalist in the Robert Wood Johnson Physician Faculty Scholars Program competition and was awarded a grant from the North American Pediatric Renal Trials and Cooperative Studies group to study hypertension in pediatric patients with chronic renal failure. Drs. McNiece, Ilyas and Wells continue to be active in pharmacologic studies of antihypertensive medications. Dr. Ellis remains the center PI for the North American Pediatric Renal Trials and Cooperative Studies. In addition to the Pediatric Nephrology elective offered to pediatric and medicine‐pediatric residents, a “combo” elective is now offered with residents rotating into the pediatric nephrology clinics during this clinical month. Dr. Richard Blaszak continues his work with the Pediatric Residency Program in his role as Associate Program Director. Faculty (Nephrology) Clinical Educator Associate Professor Blaszak, Richard T. Ilyas, Mohammad Clinical Scientist Assistant Professor McNiece, Karen L. Professor Ellis, Eileen N. Grants (Nephrology) Primary Investigator/ Project Title Awarded Blaszak, Richard Comparison of the Safety and Efficacy of Three Venofer Iron Maintenance Regimens in Pediatric Chronic Kidney Disease Patients Ellis, Eileen Focal Segmental Glomerulosclerosis FSGS Trial Pharmacogenetics of Mycophenolic Acid in Kidney Transplant Patients Ilyas, Mohammad A Randomized, Double‐Blind, Placebo Controlled, Multicenter, Parallel‐Arm Study Assessing the Efficacy, Safety, and Dose‐Response of Ramipril for the Treatment of Hypertension in Children and Adolescents 70 Funding Agency Agency Award Number NAPRTCS 1VEN03017 $7,836 $1,798 $21,250 NIH 1194‐2 $1,329 $412 $33,282 Cincinnati Children's Hospital MMF $1,100 $418 $2,899 King Pharmaceuticals K726‐06‐4003 $5,997 $1,415 $31,274 Annual Report: 2008‐2009 | UAMS Department of Pediatrics ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect Project Dates Budget Year $4,875 3/20/2007 3/20/2007 3/31/2009 3/31/2009 $10,318 6/1/2004 6/1/2004 8/31/2008 8/31/2008 $1,101 5/15/2007 5/15/2007 12/31/2009 12/31/2009 $7,381 6/5/2007 6/5/2007 4/1/2008 10/1/2008 Primary Investigator/ Project Title McNiece, Karen A Phase III, Randomized, Open‐Label, Parallel‐Group, Dose‐Ranging Clinical Trial to Study the Safety and Efficacy of MK‐0954/Losartan Potassium in Pediatric Patients with Hypertension An 8 day open‐label, multiple‐dose, multi‐center study to evaluate the safety/tolerability and Pharmacokinetics of Aliskiren in hypertensive pediatric and adolescent patients 6‐17 YO Pending McNiece, Karen Case Western Reserve University Cleveland Clinic CTSA ‐ Supplement Effect of BMI on Exposure Response Relationships to Lisinopril in Children ‐ Supplement Not Awarded McNiece, Karen Hypertension in Arkansas Youth (HAY): Influence of Overweight and Fitness on Early Cardiovascular Disease Funding Agency Agency Award Number ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect Parexel 0954‐337‐00 $14,650 $4,395 $29,380 $8,814 Novartis Spp100A; Study : 2256; Center: 1005 $19,400 $5,820 $33,037 $9,911 11/1/2008 11/1/2008 3/31/2010 3/31/2010 Case Western Reserve 2032‐1 $0 $00 $8,377 $0 10/1/2009 10/1/2009 9/30/2010 9/30/2010 Case Western Reserve 2031‐1 $0 $0 $16,754 $7,874 10/1/2009 10/1/2009 9/30/2010 9/30/2010 Robert Wood Johnson Fdtn. 1930‐1 $0 $0 $300,000 $0 Project Dates Budget Year 2/3/2009 2/3/2009 1/31/2010 1/31/2010 7/1/2009 7/1/2009 6/30/2012 6/30/2012 Publications (Nephrology) Journal Articles Copeland DR, Blaszak RT, Tolleson JS, Saad DF, Jackson RJ, Smith SD, Kokoska ER. Laparoscopic Tenckhoff catheter placement in children using a securing suture in the pelvis: comparison to the open approach. J Pediatr Surg 2008 Dec; 43(12):2256 ‐ Ellis EN, Martz K, Talley L, Ilyas M, Pennington KL, Blaszak RT. Factors related to long term renal transplant function in children. Pediatr Nephrol 2008 July; 23(7):1149‐1155. Fussell JJ, Farrar HC, Blaszak R, Sisterhen LL. Incorporating The ACGME Educational Competencies Into Morbidity And Mortality Review Conference. Teach Learn Med 2009 July; 21(3):233‐239. Prausa SE, Fukuda T, Maseck D, Curtsinger KL, Liu C, Zhang K, Nick TG, Sherbotie JR, Ellis EN, Goebel J, Vinks AA. UGT genotype may contribute to adverse events following medication with mycophenolate mofetil in pediatric kidney transplant recipients. Clin Pharmacol Ther. 2009 May;85(5):495‐500. Book Chapters Ellis EN. Handbook of Dialysis Therapy. 4th ed. Philadelphia: Saunders Elsevier; 2008. Chapter 88. Infant hemodialysis, pp. 1262‐1270. National Professional Positions (Nephrology) Other National Professional Positions Ellis, Eileen N. American Academy of Pediatrics, Chair, Nominations Committee, Nephrology Section, 2005 ‐ 2008 Honors & Awards (Nephrology) Blaszak, Richard T. 71 Dean's Resident Teaching Award, University of Arkansas for Medical Sciences, 2008 ‐ 2009 Teacher of the Year, University of Arkansas for Medical Sciences, 2008 ‐2009 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Neurology The Pediatric Neurology Section enjoyed a successful and rewarding FY09. The Section added two new faculty members with the recruitment of Dr. David Walters at the ACH campus and Dr. Tonya Balmakund at the Centers for Children in Lowell. As a result of the latter addition, the Section now operates a full‐time outpatient Child Neurology Clinic in northwest Arkansas that includes an EEG lab. The clinic schedule at the Lowell site is already completely booked for several months in advance. The addition of Dr. Walters has resulted in expansion of the Botulinum therapy program in the Spasticity Clinic. FY09 saw Neurology Clinic patient visits increase 13% from 6,519 in FY08 to 7,367 in FY09. Inpatient and outpatient testing and procedures, including neuro procedures, EEGs, videos and evoked potentials, increased 10% in FY09. Dr. Sheila Asghar was awarded a CUMG grant for the initiation of a research project evaluating EEG in children with Autism, and has also become a working member of the Autism Treatment Network team. Dr. Greg Sharp was endowed as the first recipient and holder of the John H. Bornhofen, MD Chair in Child Neurology. In education, the Child Neurology Residency Program was accredited with a four‐year cycle and presently has three residents in the program. Faculty (Neurology) Instructor Asghar, Sheila J. Walters, W. David Clinical Attending Clinical Assistant Professor Bornhofen, John H. Clinical Associate Professor Balmakund, Tonya Clinical Educator Assistant Professor El‐Nabbout, Bassem H. Ionita, Cristian Lange, Bernadette M. Shbarou, Rolla Williamson, Randy Professor Griebel, May L. Sharp, Gregory B. Grants (Neurology) Primary Investigator/ Project Title Awarded Griebel, May Childhood Absence Epilepsy Childhood Absence Epilepsy Shbarou, Rolla Childhood Absence Epilepsy Pending Asghar, Sheila Genetic Pathways in Autism Spectrum Disorders Sharp, Greg Antiepilepsy Drug Effectiveness in Pediatric Localization Related Epilepsy Shbarou, Rolla Impact of Initial Therapy and Response on Long Term Outcome in Children with CAE 72 Funding Agency Agency Award Number NIH Ro1 ns045911‐01a1 NIH NIH ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect Project Dates Budget Year $12,493 $230 $62,500 $1,151 9/30/2003 11/1/2004 10/31/2009 10/31/2009 1003‐10 $6,200 $1,798 $18,448 $5,350 9/30/2003 11/1/2007 10/31/2008 10/31/2008 1003‐12 $4,130 $1,197 $6,229 $1,806 9/30/2003 11/1/2008 10/31/2009 10/31/2009 NIH 2056‐1 $0 $0 $23,601 $10,479 1/1/2010 1/1/2010 12/31/2014 12/31/2010 NIH 2064‐1 $0 $0 $31,161 $14,645 4/1/2010 4/1/2010 3/31/2015 3/31/2011 Cincinnati Children's Hospital 1999‐1 $0 $0 $32,238 $11,929 11/1/2009 11/1/2009 10/31/2014 10/31/2010 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Publications (Neurology) Journal Articles Hall RW, Shbarou RM. Drugs of choice for sedation and analgesia in the neonatal ICU. Clin Perinatol. 2009 Jun;36(2):215‐26, vii. Hall RW, Shbarou RM. Drugs of choice for sedation and analgesia in the neonatal ICU. Clin Perinatol. 2009 Mar;36(1):15‐26. Book Chapters Griebel M. Casebook of Sleep Medicine: A Learning Companion to the ICSD. 2nd Edition ed. Westchester, Illinoise: American Association of Sleep Medicine; 2008. National Professional Positions (Neurology) Editorial/Study Section Activities Sharp, Gregory B. Contributing Reviewer. Practical Reviews in Neurology, Oakstone Medical Publishing. Sponsored by the American Academy of Neurology, Editorial Board, 1998‐present Honors & Awards (Neurology) El‐Nabbout, Bassem H. Griebel, May L. Sharp, Gregory B. Outstanding Leadership of the NF Clinic and Treatment of Children with Neurofibromatosis, Children's Tumor Foundation, 2008 America's Top Pediatricians , 2008 Best Doctors in America, 2008 Best Doctors in America, 2008 John H. Bornhofen, MD Endowed Chair in Child Neurology, University of Arkansas for Medical Sciences, 2009 Partners for Inclusive Communities Partners for Inclusive Communities is a program of UAMS and receives federal funding from the Administration on Developmental Disabilities and other agencies to conduct research and provide education, training, technical assistance, information and services to people with disabilities, their families and students and professionals involved with disability related programs. Partners' activities are constantly evolving to reflect the priorities of individuals with disabilities. Faculty (Partners for Inclusive Communities) Research Scientist Research Assistant Professor Conners‐Burrow, Nicola A. McKelvey, Lorraine 73 Research Professor Whiteside‐Mansell, Leanne Annual Report: 2008‐2009 | UAMS Department of Pediatrics Grants (Partners for Inclusive Communities) Primary Investigator/ Project Title Funding Agency Agency Award Number Winthrop Rockefeller Fnd NA DHHS ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect Project Dates Budget Year Awarded Conners‐Burrow, Nikki Addiction Treatment Gap in Arkansas Project Evaluation Supplement Arkansas Outreach and Treatment Project for Pregnant and Postpartum Women $14,545 $1,455 $14,545 $1,455 1/2/2009 1/2/2009 6/30/2009 6/30/2009 5 H79 TI018332‐03 $974,106 $95,179 $1,297,623 $126,789 9/30/2006 9/30/2008 9/29/2009 9/29/2009 Substance Abuse 1 H 79 TI08332‐02 & Mental Health Svcs. $322,633 $31,524 $1,297,623 $126,789 9/30/2006 9/30/2007 9/29/2009 9/29/2008 Substance Abuse 1 H79 TI16616‐04 & Mental Health Svcs. $312,507 $30,951 $312,507 $30,951 7/1/2005 7/1/2008 6/30/2010 6/30/2009 $11,784 6/1/2008 6/1/2008 6/30/2009 6/30/2009 Arkansas Outreach and Treatment Project for Pregnant and Postpartum Women Decision Point Treatment for the Homeless, Administration McKelvey, Lorraine Children''s Exposure to Violence at Home and in the Community: Pathways to Outcomes at age 18 ICF‐EHS Research Second Looks: Examining the Effectiveness of Early Head Start Second Looks: Examining the Effectiveness of Early Head Start XTRIA, LLC Subcontract Agreement Whiteside‐Mansell, Leanne Early Head Start 5th‐Grade Follow‐up Study Early Head Start 5th‐Grade Follow‐up Study The Family Map: An Integrated Assessment of the Parenting Environment in Early Childhood The Infant‐Toddler Family Map: A Foundation for Parent‐Teacher Partnerships Pending Conners‐Burrow, Nikki Benton County Drug Court Recovery System of Care McKelvey, Lorraine Re‐examining the Effectiveness of Early Head Start Whiteside‐Mansell, Leanne Arkansas Better Chance for School Success Evaluation (ABC) Care & Early Childhood Eudcation Family Map For Safety Project LAUNCH The Infant‐Toddler Family Map: A Foundation for Parent‐Teacher Partnerships Not Awarded Conners‐Burrow, Nikki Arkansas Connections for Kids 74 Robert Wood Johnson Fdn 63547 $90,746 $10,889 $98,205 DHHS NA $20,832 $4,167 $20,832 $4,167 12/1/2008 12/1/2008 5/31/2009 5/31/2009 DHHS 90YR0011/01 $7,855 $2,042 $31,249 $8,125 10/1/2007 10/1/2007 9/30/2009 9/30/2008 DHHS/Admin for Child/Families 90YR0011/02 $23,373 $6,077 $31,249 $8,125 10/1/2007 10/1/2008 9/30/2009 9/30/2009 DHHS HHSP233200600001T Contract 233‐02‐0089 $10,127 $2,633 $39,684 $10,316 10/24/2006 10/24/2007 9/24/2008 9/24/2008 DHHS/Admin for Child/Families HHSP233200600003T Contract No. 233‐02‐0086 $6,783 $1,764 $40,040 $10,411 10/30/2006 9/1/2007 8/31/2008 8/31/2008 DHHS/Admin for Child/Families HHSP233200600003T $34,862 Contract No. 233‐02‐0086 $9,065 $40,040 $10,411 10/30/2006 9/1/2008 8/14/2009 8/14/2009 DHHS/Admin for Child/Families 90FY0051/03 $60,845 $13,707 $488,762 $110,104 9/30/2004 9/30/2006 9/29/2008 9/29/2008 DHHS 90YD0254/01 $267,247 $68,232 $356,979 $91,142 9/30/2008 9/30/2008 9/29/2011 9/30/2009 Substance Abuse & Mental Health Svcs. $0 $0 $23,259 $5,917 10/1/2009 10/1/2009 9/30/2012 9/30/2009 Substance Abuse & 0‐0 Mental Health Svcs. $0 $0 $103,128 $26,345 10/1/2009 10/1/2009 9/30/2012 9/30/2010 NIH 0‐0 $0 $0 $22,700 $5,902 7/1/2008 7/1/2008 6/30/2010 6/30/2009 AR Dept of Human Svcs/Div of Child 0‐0 $0 $0 $303,959 $24,316 7/1/2007 7/1/2008 6/30/2008 6/30/2009 NIH 0‐0 $0 $0 $397,536 $102,309 9/30/2009 9/30/2009 9/29/2011 9/29/2010 Substance Abuse & 0‐0 Mental Health Svcs. $0 $0 $99,721 $25,927 10/1/2008 10/1/2008 9/30/2013 9/30/2009 DHHS 0‐0 $0 $0 $356,979 $91,142 9/30/2008 9/30/2009 9/29/2011 9/29/2010 DHHS $0 $0 $282,597 $70,974 Annual Report: 2008‐2009 | UAMS Department of Pediatrics 7/1/2008 7/1/2008 6/30/2014 6/30/2009 Publications (Partners for Inclusive Communities) Journal Articles McKelvey L, McKelvey LM. Validity of the Short Form of the Parenting Stress Index for Fathers of Toddlers. J Child and Family Studies 2009 18:102‐111. McKelvey L. Parenting and Preschool Child Development: Examination of Three Low‐Income U.S. Cultural Groups. J Child and Family Studies 2009 (18):48‐60. Shears J, Whiteside‐Mansell L, McKelvey L, Selig, J. Assessing mothers' and fathers' authoritarian attitudes: The psychometric properties of a brief survey. Social Work Research 2008 32:179‐184. Whiteside‐Mansell L, Bradley RH, Casey PH, Fussell JJ, Conners‐Burrow NA. Triple Risk: Do Difficult Temperament and Family Conflict Increase the Likelihood of Behavioral Maladjustment in Children Born Low Birth Weight and Preterm? J Pediatr Psychol. 2009 May;34(4):396‐405. Whiteside‐Mansell L, Bradley RH, McKelvey L. Parenting and Preschool Child Development: Examination of Three Low‐Income U.S. Cultural Groups. Journal of Child and Family Studies 2009 18:48‐60. Pediatric Administration The Office of Pediatrics Administration provides leadership and support functions for the faculty and staff of the DOP. The DOP is administered by Dr. Richard F. Jacobs, Chair of the Department of Pediatrics. The Chair is assisted by four Vice Chairs: Dr. Michele Moss, Vice Chair for Clinical Services; Dr. Chris Smith, Vice Chair for Education; Dr. John Fowlkes, Vice Chair for Research; and Dr. Pat Casey, Vice Chair for Faculty Affairs. The Department is also supported by various business and support functions overseen by Mr. Mark Amox, Business Administrator, and includes the areas of finance, human resources, professional billing, computer support, business development and general administration. Mr. Tom East, Senior Advisor, oversees facilities planning and serves as liaison for the statewide Collaborative between UAMS and ACH. Faculty (Pediatric Administration) Clinical Scientist Professor Jacobs, Richard F. Yamauchi, Terry Basic Scientist Professor Cranmer, Joan M Office of Education Research Scientist Research Assistant Professor Boateng, Beatrice Grants (Pediatric Administration) Primary Investigator/ Project Title Awarded Cranmer, Joan 25th International Neurotoxicology Conference: Environmental Etiologies of Neurological Disorders 75 Funding Agency Agency Award Number NIH/NIEHS HHSN273200800197P Annual Report: 2008‐2009 | UAMS Department of Pediatrics ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect $10,000 $0 ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect $10,000 $0 Project Dates Budget Year 8/4/2008 8/4/2008 10/16/2008 10/16/2008 Primary Investigator/ Project Title Funding Agency Agency Award Number ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect Project Dates Budget Year Environmental Etiologies of Neurological Disorders (NEUROTOXICOLOGY24) NEUROTOXICOLOGY 25: Environmental Etiologies of Neurological Disorders: Scientific, Translational & Policy Implications NEUROTOXICOLOGY 25: Environmental Etiologies of Neurological Disorders: Scientific, Translational and Policy Implications ‐ March of Dimes Jacobs, Richard A Placebo Controlled, Phase III Evaluation of Suppressive Tx with Oral Acyclovir Suspension Following Neonatal Herpes Simplex Virus Infections Limited to the Skin, Eye and Mouth A Placebo‐Controlled Phase III Evaluation of Suppressive Therapy with Oral Acyclovir Suspension Following Neonatal Herpes Simplex Virus Infections Involving the Central Nervous System An Evaluation of the PK Profile and Safety of a single dose of Daptomycin in Pediatric subjects aged 2 to 6 years who are concurrently receiving standard antibotic theraby for proven or suspected gram positive infection An Open Label, Parallel Group Study to Evaluate the Single‐Dose PK and Safety of Doripenem in Hospitalized Ped Patients 3 months to 17 years, Inclusive An Open‐Label Study to Evaluate the Single‐Dose Pharmacokinetics and Safety of Ceftabiprole in Pediatric Subjects 3 months to < 18 YO Undergoing Treatment with Systemic Antibiotic NIH/NIEHS 1 U13 ES016515‐01 $4,615 $0 $26,203 $0 9/15/2007 9/15/2007 8/31/2008 8/31/2008 NIH/NIEHS 1 R13 ES017188‐01 $23,980 $0 $29,252 $0 9/22/2008 9/22/2008 8/31/2009 8/31/2009 March of Dimes 4‐FY08‐517 $5,000 $0 $5,000 $0 8/1/2008 8/1/2008 12/31/2008 12/31/2008 UAB CASG104 $3,009 $46 $39,396 $604 7/1/1997 7/1/1997 7/31/2010 7/31/2010 UAB CASG103 $3,009 $46 $39,396 $604 7/1/1997 7/1/1997 7/31/2010 7/31/2010 Cubist DAP‐PEDS‐07‐02 $34,656 $8,263 $37,760 $9,003 6/1/2008 6/1/2008 5/31/2009 5/31/2009 J&J DORINOS1008 $9,399 $2,212 $29,795 $7,011 7/2/2007 7/2/2007 8/31/2010 8/31/2010 J&J 30982081CSI1006 $14,867 $3,566 $43,054 $10,326 10/10/2007 10/10/2007 8/31/2010 8/31/2010 Publications (Pediatric Administration) Journal Articles Cory‐Slechta DA, Weiss B, Cranmer JM. The Environmental Etiologies of Neurobehavioral Deficits and Disorders: Weaving Complex Outcomes and Risk Modifiers into the Equation. Neurotoxicology, An International Journal 2008 September; 29(5):759‐760. Cranmer JM. Twenty‐Fifth International Neurotoxicology Conference: Meeting Report. Neurotoxicology, An International Journal 2009 January; 30(1):165‐166. Cranmer JM. Twenty‐Fourth International Neurotoxicology Conference: Meeting Report. Neurotoxicology, An International Journal 2008 September; 29(5):753‐758. Book Chapters Boateng BA. African Media, African Children. Nordicom; 2008. Children's Television in South Africa: Mandates to Serving the Children. Cross JT, Jacobs RF. Textbook of Pediatric Infectious Disease, 6th edition. Feigin RD, Cherry JD ed. Philadelphia, Pennsylvania: WB Saunders Co; 2009. Chapter 108. Other Mycobacteria, pp 1469‐1479. Cross JT, Jacobs RF. Textbook of Pediatric Infectious Disease, 6th edition. Feigin RD, Cherry RD ed. Philadelphia, Pennsylvania: WB Saunders Co; 2009. Chapter 39. Fungal Meningitis, pp 481‐490. Harik N, Jacobs RF. Textbook of Pediatric Infectious Disease, 6th edition. Feigin RD, Cherry JD ed. Philadelphia, Pennsylvania: WB Saunders Co; 2009. Chapter 110. Nocardia, pp 1504‐1508. Jacobs RF, Schutze GE. Harrison's Principles of Internal Medicine, 17th edition. Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL ed. McGraw‐Hill; 2008. Chapter 151. Tularemia. 76 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Schutze GE, Jacobs RF. Infections of Leisure, 4th Edition. Schlossberg ed. Washington, DC: ASM Press; 2009. Chapter pp. 97‐110. The Camper's Uninvited Guests. Schutze GE, Jacobs RF. Principles and Practice of Pediatric Infectious Diseases, 3rd Edition. Long/Pickering/Prober ed. Churchill Livingstone, Elsevier Inc, 2008. Chapter 160, pp 851‐855. Bartonella Species (Cat‐Scratch Disease). Starke JR, Jacobs RF. Principles and Practice of Pediatric Infectious Diseases, 3rd Edition. Long/Pickering/Prober ed. Churchill Livingstone, Elsevier, Inc, 2008. Chapter 134, pp 770‐788. Mycobacterium Tuberculosis. Wheeler JG, Jacobs RF. Textbook of Pediatric Infectious Disease, 6th edition. Feigin RD, Cherry JD ed. Philadelphia, Pennsylvania: WB Saunders Co; 2009. Chapter 29. Pleural Effusions and Empyema, pp 325‐335. Wheeler JG, Jacobs RF. Textbook of Pediatric Infectious Disease, 6th edition. Feigin RD, Cherry JD ed. Philadelphia, Pennsylvania: WB Saunders Co; 2009. Chapter 30. Lung Abscess, pp 336‐342. Whitworth S, Jacobs RF. Textbook of Pediatric Infectious Disease, 6th edition. Feigin RD, Cherry JD ed. Philadelphia, Pennsylvania: WB Saunders Co; 2009. Chapter 137. Actinobacillus Actinomycetemcomitans, pp 1674. Whitworth S, Jacobs RF. Textbook of Pediatric Infectious Disease, 6th edition. Feigin RD, Cherry JD ed. Philadelphia, Pennsylvania: WB Saunders Co; 2009. Chapter 161. Actinomycosis, pp 1880‐1884. Books Cranmer JM. editor. NeuroToxicology, An International Journal. Elsevier; 2009. 30:1‐3 1‐486 p. Cranmer JM. editor. NeuroToxicology, An International Journal. Elsevier; 2008. 29:1‐6 1‐1164 p. National Professional Positions (Pediatric Administration) Editorial/Study Section Activities Cranmer, Joan M. Neurotoxicology, An International Journal, Editor‐in‐Chief, 1979 to present Study Section: 2008 NIEHS Annual Superfund Basic Research Program (P42) Review Meeting (Special Emphasis Panel RFA ES07‐006), RTP, NC (November 5‐7, 2008), Grant Review, 2008‐2008 Study Section: NIEHS Childrens Centers Review ‐ 07/21‐24/09 (Teleconference), Grant Review, 2009‐2009 Study Section: NIEHS R13 Review. The Environmental Health Sciences Review Committee and Ad Hoc Reviewers. November 12‐13 Review of T32, K99/R00, K08 and R13 Applications (2‐day Teleconference), Grant Review, 2008‐2008 Study Section: Review Committee (Caudle) K99 Application. April 1, 2009, Grant Review, 2009‐2009 Jacobs, Richard F. ADIS International: Pediatric Drug Therapy, Editorial Board, 2001‐2008 Associate Medical Editor. Infectious Diseases in Children. Slack, Inc., Medical Editor, 2003‐present 77 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Infectious Diseases in Children, Editorial Board, 2001‐present Journal of Pediatric Pharmacology and Therapeutics, Editorial Board, 2000‐2010 Seminars in Pediatric Infectious Diseases, Editorial Board, 1998‐2008 The Pediatric Infectious Disease Journal, Editorial Board, 1992‐2008 Other National Professional Positions Jacobs, Richard F. American Board of Pediatrics, Associate Member, 2004 ‐ 2008 American Board of Pediatrics, Credentials Committee, Board Member, 2006‐ 2010 American Board of Pediatrics, Pediatric Infectious Diseases‐Sub‐board, Chairman, 2008 ‐ 2010 American Board of Pediatrics, Pediatric Infectious Diseases‐Sub‐board, Member, 2004 ‐ 2010 Infectious Diseases Society of America, Chairman, Finance Committee, 2007 ‐ 2010 National Center for Toxocological Research (NCTR), Science Advisory Board, FDA‐NCTR, 2006 ‐ 2008 National Institutes of Health (NIH), Investigator, NIH/NICHD, Pediatric Pharmacology Research Unit, 1993 ‐ present National Institutes of Health (NIH), Member, NIH/NIAID Collaborative Antiviral Study Group, 1982 – present Honors & Awards (Pediatric Administration) Cranmer, Joan M. Jacobs, Richard F. 78 Distinguished Service Award to Recognize the Highest Standards of Quality in Neurotoxicology, Society of Toxicology: Neurotoxicology Specialty Section, 2008 Recognition Award for Joan Marie Cranmer, PhD for twenty‐five years of dedicated service to the International Neurotoxicology Conference and to the field of Neurotoxicology , The Neurotoxicology Research Community,2008 America's Top Doctors, 2008 America's Top Doctors, 2009 Best Doctors in America, 2008 Best Doctors in America, 2009 Henderson Academy, Academic Hall of Fame ‐ Biology, Henderson State University, 2008 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Yamauchi, Terry Red Sash Award for Excellence in Teaching, University of Arkansas for Medical Sciences, 2008 Red Sash Award for Excellence in Teaching, University of Arkansas for Medical Sciences, 2009 Who's Who in Medical Sciences Education, Academic Keys, 2007 ‐ 2008 "Best of the Best" Top Pediatrician in Central Arkansas, Arkansas Democrat‐Gazette, 2008 "Best of the Best" Top Pediatrician in Central Arkansas, Arkansas Democrat‐Gazette, 2009 Inaugural Esther Pohl Lovejoy, MD Alumni Leadership Award, Oregon Health Sciences University, 2008 Red Sash Award for Excellence in Teaching, University of Arkansas for Medical Sciences, 2009 Pharmacology & Toxicology The Section of Clinical Pharmacology and Toxicology had numerous significant accomplishments in FY09. The Section continues to provide clinical consultation and in‐patient service to pediatric patients with poisoning and envenomation and children that are s/p intensive care unit admissions that are in need of opioid and benzodiazepine tapers. In addition, affiliate faculty members from the School of Pharmacy continue to provide 24 hour coverage for therapeutic drug monitoring. The Antimicrobial Stewardship Program was established this year by Dr. Holly Maples, an affiliate faculty member from the College of Pharmacy, in conjunction with the Section of Infectious Diseases. In the first year of its existence, the program significantly reduced vancomycin utilization at ACH. FY09 was a particularly strong year for research funding within the section. Section faculty members have two NIH grants on acetaminophen toxicity. These two grants focus on the development of diagnostic assays for acetaminophen toxicity and the relationship of VEGF to repair processes in the mouse liver. A new grant was awarded in the spring of 2009 to address acetaminophen toxicity in children. This new grant is also sponsored by the NIH and will be a collaborative partnership with experts in proteomics and metabolomics from within the UAMS institution and within the state at the National Center for Toxicologic Research. Importantly, the new grant will be performed in collaboration with six other pediatric centers. In addition, a patent application was submitted by UAMS Bioventures as a result of research activities by the Section, Drs. Laura James and Dean Roberts, and Dr. Jack Hinson of the UAMS Department of Pharmacology and Toxicology. Other research activities conducted by the Section are related to the Pediatric Pharmacology Research Unit at ACH which is in its 16th year of NIH funding. This grant allowed DOP researchers and ACH employees to participate in over 16 clinical trials during FY09. These clinical trials will generate safety, dose, and pharmacogenetic data relevant to pediatric therapeutics. Section members continue to serve as experts to national organizations including the US Food and Drug Administration and the American Academy of Pediatrics. In addition, Section members are responsible for major educational initiatives within the Department with Dr. Hank Farrar serving as Pediatrics Residency Program Director. Dr. Tom Wells continues to serve the UAMS research community in his role as Director of the Research Support Center at UAMS. 79 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Faculty (Pharmacology & Toxicology) Instructor Pesek, Robert D. Clinical Educator Professor Farrar, Henry C. Clinical Scientist Professor James, Laura P. Wells, Thomas G. Research Scientist Research Associate Professor Roberts, Dean W. Grants (Pharmacology & Toxicology) Primary Investigator/ Project Title Awarded James, Laura A Multicenter, Open‐Label, Single Dose Study to Evaluate the Safety, Tolerability, and Plasma Concentration Profiles of MK‐0633 in Asthmatic Children Aged 6 to Less than 12 Years An Open‐Label Pharmacokinetic Study of Hydrocodone/Acetaminophen in Children Ages 6‐17 with Moderate to Severe Postoperative Pain Dose‐Ranging, Safety and Efficacy of Cathflo Activase for the Treatment of Central Catheter Occlusion in Neonates and Infants GSK Service Agreement HIF‐1alpha and VEGF in Acetaminophen Toxicity and Repair HIF‐1alpha and VEGF in Acetaminophen Toxicity and Repair HIF‐1alpha and VEGF in Acetaminophen Toxicity and Repair Ident. Of new mechanistic biomarkers of adverse responses to acetaminophen in children and adolescents Multi‐Center Study of Acute Liver Failure in Children Multi‐Center Study of Acute Liver Failure in Children Network of Pediatric Pharmacology Research Units Pediatric Pharmacology Research Units ‐ Supplement Funds Pilot Study to Evaluate the Oral Absorption, Safety, and Tolerability of Nepadutant Administered as a Single Oral Dose to Infants with Colic Validating an Experimental Acetaminophen‐Protein Adduct Asay for Clinical Application Wells, Tom A Multicenter, Randomized, Double‐Blind, Parallel‐group, Evaluation of 12 weeks of valsartan compared to enalapril on sitting systolic blood pressure in children 6 to 17 years of age with hypertension A Prospective, Randomized, Double‐Blind, Placebo‐Controlled, Evaluation of the Safety, Efficacy and PK of MICARDIS in Children & Adolescents with HTN after 4 weeks of TX. An Open‐Label Study of the Single‐Dose Pharmacokinetics of Olmesartan Medoxomil in Pediatric Patients with Hypertension Pending James, Laura Case Western Reserve University Cleveland Clinic CTSA ‐ Supplement HIF‐1alpha and VEGF in Acetaminophen Toxicity and Repair ‐ Administrative Supplement Metabolism and Toxicity of Acetaminophen in Preterm Infants Multi‐Center Study of Acute Liver Failure in Children ‐ Pittsburgh PALF Fee for Service Subcontract 80 Funding Agency Agency Award Number Merck MK0633/023 $29,288 $8,786 $50,526 $15,158 12/2/2008 12/2/2008 11/30/2009 11/30/2009 Abbott M10‐373 $39,731 $11,919 $39,731 $11,919 12/8/2008 12/8/2008 11/30/2009 6/3/2009 Genentech Foundation Alteplase $648 $96 $3,700 $550 2/15/2006 2/15/2006 12/31/2008 12/31/2008 GlaxoSmithKline 09KOP00220 $843 $253 $2,115 $635 3/1/2009 3/1/2009 12/31/2009 12/31/2009 NIH 1895‐2 $146,684 $68,942 $146,684 $68,942 8/1/2008 8/1/2008 5/31/2012 5/31/2009 NIH 1895‐5 $85,045 $39,971 $171,500 $80,605 8/1/2008 6/1/2009 5/31/2012 5/31/2010 NIH/NIDDK 5 R01 DK075936‐02 $88,516 $39,758 $171,500 $77,032 8/24/2007 8/1/2008 NIH 1760‐3 $214,199 $82,243 $343,191 NIH 1432‐6 $488 $122 $2,880 $720 9/1/2005 9/1/2007 8/31/2008 8/31/2008 NIH 1432‐8 $2,122 $530 $2,556 $639 9/1/2005 9/1/2008 8/31/2009 8/31/2009 NIH 303‐40 $142,896 $41,440 $286,184 $82,993 1/1/2004 1/1/2008 12/31/2009 12/31/2009 NIH NoA: 3 U10 HD031324‐15S1 $70,359 $33,069 $140,911 $66,228 1/1/2008 1/1/2008 12/31/2009 12/31/2009 KAI 1814‐2 $8,599 $1,832 $11,850 $2,525 2/14/2008 2/14/2008 6/30/2009 6/30/2009 Denver Health Denver Health 2 $25,954 $6,489 $91,968 $22,992 3/21/2007 3/21/2007 12/31/2008 12/31/2008 Novartis CVAL489 $13,232 $3,170 $41,930 $10,045 2/16/2007 2/16/2007 2/16/2009 2/16/2009 Boehringer 503.403 $1,914 $454 $34,542 Sankyo CS0866‐A‐U102 $4,553 $1,099 $55,908 $13,490 8/17/2005 8/17/2005 8/31/2007 10/1/2008 Case Western Reserve 2033‐1 $0 $0 $55,391 $26,034 10/1/2009 10/1/2009 9/30/2010 9/30/2010 NIH/NIDDK 1895‐4 $0 $0 $58,150 $23,570 6/1/2009 6/1/2009 5/31/2012 5/31/2010 NIH 1863‐2 $0 $0 $7,732 $3,634 4/1/2010 4/1/2009 3/31/2015 3/31/2011 NIH/NIDDK 1432‐9 $0 $0 $10,000 $2,500 9/1/2005 9/1/2009 8/31/2010 8/31/2010 Annual Report: 2008‐2009 | UAMS Department of Pediatrics ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect Project Dates Budget Year 6/1/2008 8/1/2008 $131,771 6/15/2009 6/15/2009 3/31/2014 3/31/2010 $8,198 5/9/2006 5/9/2006 5/9/2008 8/15/2008 Publications (Pharmacology & Toxicology) Journal Articles Blumer J, Batisky DL, Wells T, Shi V, Solar‐Yohay S, Sunkara G. The Pharmacokinetics of Valsartan in Pediatric and Adolescent Subjects with Hypertension. J Clin Pharmacol 2009 :49:235‐241. Franks AM, O'Brien CE, Stowe CD, Wells TG, Gardner SF. Candesartan Cilexetil Effectively Reduces Blood Pressure in Hypertensive Children . AnnPharmacother 2008 42(10):1388‐1395. Fussell JJ, Farrar HC, Blaszak R, Sisterhen LL. Incorporating The ACGME Educational Competencies Into Morbidity And Mortality Review Conference. Teach Learn Med 2009 July; 21(3):233‐239. Hong H, Teitel C, James LP, Tong W, Hinson JA, Fuscoe JC, Dragan Y. SELDI based proteomic determination of hepatic biomarkers in mourse serum following acetaminophen administration. Journal of Proteomics and Bioinformatics 2008 1(8):424‐436. James LP, Capparelli EV, Simpson PM, Letzig L, Roberts D, Hinson JA, Kearns GL, Blumer JL, Sullivan JA, and the Network of Pediatric Pharmacology Units. Acetaminophen‐Associated Hepatic Injury: Evaluation of Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Overdose. Clin Pharmacol Ther. 2008 Dec;84(6):684‐90 James LP, Letzig L, Simpson PM, Capparelli E, Roberts DW, Hinson JA, Davern TJ, Lee WM. Pharmacokinetics of acetaminophen protein adducts in adults with acetaminophen overdose and acute liver failure. Drug Metab Dis 2009 August; 37(8):1779‐1784. Kearns GL, Blumer J, Schexnayder S, James LP, Adcock KG, Reed MD, Daniel JF, Gaedigk A, Paul J. Single‐dose pharmacokinetics of oral and intravenous pantoprazole in children and adolescents. J Clin Pharmacol 2008 November; 48(11):1356‐1365. O'Brien C, Harik N, James L, Seib P, Stowe C. Cesium‐Induced QT‐Interval Prolongation in an Adolescent. Pharmacotherapy 2008 August; 28(8):1059‐65. National Professional Positions (Pharmacology & Toxicology) Editorial/Study Section Activities James, Laura P. Journal of Clinical Pharmacology and Therapeutics, Associate Editor, 2008‐present Paediatric and Perinatal Drug Therapy, Editorial Board, 2002‐2008 Special Emphasis Panel/Scientific Review Group 2009/10 ZRG1 CB‐L (50) R meeting, 08/04/2009‐08/05/2009, Panelist, 2009‐2009 Study Section ‐ NIH Hepatobiliary Physiology , Grant Review, 2008‐2009 Study Section ‐ NIH Small Business: Digestive Sciences Special Emphasis Panel, Grant Review, 2009‐2009 Wells, Thomas G. The Journal of Pediatric Pharmacology and Therapeutics, Editorial Board, 2000‐present 81 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Psychology The Pediatric Psychology Section had a productive FY09 on numerous fronts. In regard to clinical services, the Section provided services through the Dennis Developmental Center as well as various outpatient and inpatient programs at ACH. Psychological supervision services were also provided to the Project for Adolescent and Child Evaluation (Foster Care Program), Kids First, and the Arkansas Children’s Nutrition Center. New clinical collaborations this year included working with the liver transplant program to develop and implement a psychological assessment protocol for transplant patients. Faculty also started working with the Arkansas Center for Respiratory Technology‐Dependent Children to help improve patient care. Dr. Sherri Gaudette joined the Section in FY09 to provide clinical services to the DDC and the ACH medical home clinic. Faculty members from the Section were active in various educational activities, including presenting a large number of community and continuing education lectures and workshops in Arkansas. During this past year, the psychology postdoctoral fellowship program was granted membership/recognition in the Association of Psychology Postdoctoral and Internship Centers (APPIC). This will increase the number and quality of applicants to the pediatric psychology and neuropsychology fellowship program in future years. Dr. Nick Long was one of three College of Medicine faculty members to receive the Chancellor’s Faculty Teaching Award in 2008. In regard to research activities, Drs. Wendy Ward‐Begnoche, Jayne Bellando, Liz Pulliam and Jeff Snow were active in collaborating with faculty from other sections on externally funded ACHRI/UAMS research grants. The focus of these projects included the areas of autism, obesity prevention, and drug studies. Faculty also continued their grant‐ funded community‐based programs. Dr. Mark Edwards completed work on his U.S. Department of Education funded grant to reduce alcohol abuse among secondary students in the Russellville school district. Drs. Long and Edwards continued work on their U.S. Department of Education PIRC (Parental Information and Resource Center) grant. This grant provides and supports various parent education related services throughout the state. In addition to their publications, faculty members in the Section were also active in providing editorial services to numerous journals. Faculty (Psychology) Instructor Gaudette, Shari I. Pulliam, Elizabeth Clinical Attending Clinical Assistant Professor Stermock, Anne C. Clinical Associate Professor Watson, Janine E. Clinical Educator Assistant Professor Bellando, B. Jayne Associate Professor Snow, Jeffrey H. Ward‐Begnoche, Wendy L. Professor Edwards, Mark C. Clinical Scientist Associate Professor Evans, Larry D. Professor Long, Nicholas Grants (Psychology) Primary Investigator/ Project Title Awarded Edwards, Mark Russellville Alcohol Abuse Reduction Project Russellville Alcohol Abuse Reduction Project Long, Nick Center for Effective Parenting ‐ Parent Information and Resource Center 82 Funding Agency Agency Award Number Department of Education 1334‐6 $17,122 $2,397 $139,255 $19,496 8/15/2005 8/15/2007 8/14/2008 8/14/2008 Russellville School District 1334‐8 $21,982 $3,737 $21,982 $3,737 8/15/2005 8/15/2008 4/15/2009 4/15/2009 ED U310A060026 $65,120 $16,931 $259,064 $67,357 10/1/2006 10/1/2007 9/30/2011 9/30/2008 Annual Report: 2008‐2009 | UAMS Department of Pediatrics ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect Project Dates Budget Year Primary Investigator/ Project Title Funding Agency Agency Award Number Center for Effective Parenting ‐ Parent Information and Resource Center ED U310A060026 ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect $189,657 $49,311 ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect $253,571 Project Dates Budget Year $65,929 10/1/2006 10/1/2008 9/30/2011 9/30/2009 Publications (Psychology) Journal Articles Bellando J, Pulliam E. Helping the student with Asperger's Disorder with social and behavioral issues in the school: nursing, psychology, and educators working in unison. J Spec Pediatr Nurs. 2009 Jul;14(3):210‐4. Bellando J. Building friendship skills that last a lifetime. Parenting in Arkansas 2008 18(2):21. Church, JK, Pulliam E. Helping children manage stress. Parenting in Arkansas 2008 Fall/Winter; 18(2):4‐6. Evans L, Fussell J. Medical status of school‐age children reentering foster care. Child Maltreatment 2008 Dec 1. Faust D, Black FW, Abrahams J, Warner M, Bellando J. In the aftermatch of the storm: Katrina's impact of psychological practice in New Orleans. Professional Psychology: Research Practice 2008 39(1):1‐6. Long N. Closing the gap between research and practice: The importance of practitioner training. Clinical Child Psychology and Psychiatry 2008 July; 13(2):187‐190. Razzaq S, Sequiera M, Ward‐Begnoche W. Fighting Obesity: What Parents Can Do. Parenting in Arkansas. 2009. Ward‐Begnoche W, Gance‐Cleveland B, Simpson P, Parker J, Jo C, Dean J, Thompson J. Effectiveness of a school‐ based obesity prevention program. . International Journal of Health Promotion and Education 2009:51‐56. Ward‐Begnoche W, Thompson J. Economic Considerations in Treating Overweight Youth. J Ark Med Soc. 2008 Aug;105(2):43‐5. Ward‐Begnoche W, Thompson J. Family‐centered care. Assessing and surmounting barriers to eating and activity changes in overweight youth. J Spec Pediatr Nurs. 2008 Jul;13(3):229‐34. Ward‐Begnoche WL, Gance‐Cleveland B, Portilla M. Circumventing Communications Barriers with Hispanic‐Speaking Patients Regarding Pediatric Obesity. J Pediatr Health Care. 2009 Jul‐Aug;23(4):272‐280. Wyckoff SC, Miller KS, Forehand RL, Bau JJ, Fasula A, Long N, Armistead, L. Patterns of sexuality communication between preadolescents and their mothers and fathers. Journal of Child and Family Studies 2008 17:649‐662. Book Chapters Long N, Edwards M, Bellando J. Treating childhood psychopathology and developmental disorders. New York: Springer; 2008. Chapter 4. Parent training interventions. Long N. Young Parkinson's Handbook. New York: American Parkinson Disease Association; 2008. Parenting children and teens. Ward‐Begnoche WL, Pasold T, O'Neill VS, Peck D, Razzaq S, Young K. Treating Obesity Across the Lifespan. Springer Press; 2008. Chapter 1. Childhood Obesity Treatment Literature Review. 83 Annual Report: 2008‐2009 | UAMS Department of Pediatrics National Professional Positions (Psychology) Editorial/Study Section Activities Edwards, Mark C. Guest Reviewer: Clinical Pediatrics, Journal of Abnormal Child Psychology, Journal of Clinical and Consulting Psychology, Journal of Child and Family Studies, Journal of Applied Behavioral Analysis, Child Maltreatment, Psychological Reports., Editorial Board, 2004‐present Long, Nicholas Children's Health Care, Editorial Board, 1992‐present Clinical Child Psychology and Psychiatry, Associate Editor, 1996‐present Parenting in Arkansas, Editor, 1991‐present Other National Professional Positions Long, Nicholas American Psychological Association, Accreditation Site Visitor, 1993 ‐present National Parenting Education Network, National Guidance Team, 2009 ‐present National Parenting Education Network, Treasurer, 2009 ‐ present Ward‐Begnoche, Wendy National Association of Children's Hospital Research Institute National Task Force on Pediatric Obesity, Executive Commitee, 2008 ‐2010 National Association of Children's Hospital Research Institute National Task Force on Pediatric Obesity, Subcommitee adolescent bariatric surgery, 2008 ‐ 2010 National Association of Children's Hospital Research Institute National Task Force on Pediatric Obesity, Subcommittee on Care Coordination, 2008 ‐ 2010 National Association of Children's Hospital Research Institute, National Task Force on Pediatric Obesity, Subcommittee on Creation of National Research Database, 2008 ‐ 2010 Weight Bias Task Force, Subcommittee on Weight Bias in School Wellness Policies, 2009 ‐ 2010 Honors & Awards (Psychology) Long, Nicholas 84 Chancellor's Faculty Teaching Award, University of Arkansas for Medical Sciences, 2008 Educational Research Award, College of Medicine, University of Arkansas for Medical Sciences, 2008 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Pulmonology The Pediatric Pulmonology Section had an excellent year in FY09. FY09 saw the biggest increase in clinical productivity in the history of the section, despite the loss of one long‐term faculty member and the continuing recruitment for a replacement. The Section worked diligently to improve productivity and meet compliance recommendations for billing which assisted in greatly reducing the section’s budget deficit. In FY09 Dr. Marissa Guillory was recruited to join the faculty of the Pediatric Pulmonary Section and will begin July 1, 2009. She will work part‐time, devoting all of her efforts to Sleep Disorders clinics and interpretation of sleep studies. In addition, the section added a fifth specialty nurse in FY09 to assist in the care of complex respiratory technology‐dependent patients. The Arkansas Center for Respiratory Technology Dependent Children (ACRTDC), started last year, has grown tremendously and achieved several major goals in FY09, including collaboration with the UAMS adult Pulmonary Division to create and implement the first transition program for older technology‐dependent patients, facilitating a smooth and seamless transition to adult care at UAMS. In addition, the ACRTDC added a full‐time social worker to assist in managing complex children with neurodisabilities and ventilator‐dependence. The Pediatric Pulmonary Clinic at the Centers for Children in Lowell has continued to flourish and, in FY09, began providing full outpatient services to children with Cystic Fibrosis (CF). The Pediatric Pulmonary Clinic at Lowell also added an advanced practice nurse in FY09 to enhance services and increase capacity as well as Pediatric Psychology services for CF and other Pediatric Pulmonary patients in northwest Arkansas. In FY09 Dr. Ariel Berlinski was elected, after peer nomination and vote, Chair of the Pediatric Networking Group of the International Society for Aerosols in Medicine. He was became a consultant to the National Board of Respiratory Care for the Neonatal/Pediatric Specialist Examination and joined the ACH Pharmacy Therapeutics Committee. Dr. Supriya Jambhekar became co‐medical director of the ACH Sleep Disorders Center and was invited to serve on the Respiratory Care Council. Dr. Gulnur Com became co‐medical director of the Cystic Fibrosis Center, chair of the CF Center core leadership team and the CF newborn screening committee. Dr. Robert Warren received the Ruth Olive Beall Award; an award of distinction given to a physician who consistently displays the ACH Service and Behavioral Standards. Dr. John Carroll joined the Board of Directors of the Arkansas Chapter of the Cystic Fibrosis Foundation in FY09. He was reappointed to serve on the American Thoracic Society (ATS) Pediatrics Assembly Program Committee for the ATS International Conference. FY09 was also a great year for research. Section members presented 14 abstracts at five national and international meetings and one abstract locally. In addition, members of the faculty published five peer reviewed research articles, one review article and six book chapters. Drs. Carroll and Kim received an Arkansas Biosciences Institute (ABI) grant and continued in FY09 as co‐investigators on two NIH R01 grant awards. Drs. Morris and Berlinski as well as 3rd year fellow Satya Hegde each received a CUMG award in FY09. Dr. Carroll served his fourth and final year on the Respiratory Integrative and Translational Biology Study Section at NIH. Dr. Carroll also served as reviewer, for the NIH National Heart, Lung, and Blood Institute (NHLBI) Loan Repayment Program for Clinical and Pediatric Researchers. Drs. Morris and Carroll served as grant reviewers for the CUMG grant program. On the education front a new first year fellow, Dr. David Josey, was recruited from Robert Wood Johnson School of Medicine. Dr. Hassan Dbouk, the first graduate of the fellowship program last year, passed the American Board of Pediatrics Pulmonology board exam with flying colors. Dr. Martin Bauer was invited to join the ACH Continuing Medical Education Editorial Board and continues to do an outstanding job of directing the Pediatric Pulmonology Fellowship Program. 85 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Faculty (Pulmonology) Instructor Com, Gulnur Clinical Attending Clinical Assistant Professor Menendez, Astryd A. Clinical Educator Assistant Professor Berlinski, Ariel Jambhekar, Supriya Associate Professor Bauer, Martin L. Clinical Scientist Associate Professor Morris, Mohy G. Professor Carroll, John L. Warren, Robert H. Research Scientist Research Assistant Professor Kim, Insook Grants (Pulmonology) Primary Investigator/ Project Title Awarded Bauer, Marty Compassionate Use Protocol to Provide Access to ENG‐0040 in up to 6 Severly Affected Patients with Infantile Hypophophatasia (HPP) Berlinski, Ariel A Double Blind, Multicenter, Multinational, randomized, Placebo Controlled Trial Evaluating Aztreonam Lysine for Inhalation in Patient with CF, mild lung disease. A Phase 2, Multi‐Center, Randomized, Double‐Blind, Placebo‐ Controlled Study to Evaluate the Safety, Tolerability and Efficacy of Three Dosage Regimens of MP‐376 Solution for Inhalation Given for 28 Days to Stable Cystic Fibrosis Patients A Real Life Evaluation of the Performance of a Large Volume Nebulizer Carroll, John Cystic Fibrosis Data Base Mechanism of Perinatal‐hyperoxic Suppression of Chemoreceptor Function Postnatal Resetting of Carotid Chemoreceptor Sensitivity Postnatal Resetting of Carotid Chemoreceptor Sensitivity Morris, Mohy Forced expiration and lung volume in infant lung disease Pending Carroll, John Postnatal Resetting of Carotid Chemoreceptor Sensitivity Funding Agency Agency Award Number ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect Project Dates Budget Year Enobia ENB‐002‐08 $19,893 $5,968 $40,810 $12,243 1/7/2009 1/7/2009 12/31/2009 12/31/2009 Gilead GS‐US‐205‐0117 $22,090 $5,122 $24,140 $5,598 8/1/2008 8/1/2008 7/31/2009 7/31/2009 MPEX MP‐204 $24,536 $5,773 $29,710 $6,990 6/11/2008 6/11/2008 4/30/2010 4/30/2010 S&T Tech 1842‐2 $1,313 $328 $2,117 $529 2/13/2008 2/13/2008 2/12/2009 2/12/2009 Cystic Fibrosis Foundation 620‐19 $85,275 $0 $85,275 $0 7/1/2008 7/1/2008 6/30/2009 6/30/2009 NHLBI 1365‐5 $125,000 $47,500 $125,000 $47,500 7/5/2007 7/1/2008 6/30/2012 6/30/2009 NIH 1629‐2 $164,081 $34,429 $326,379 $68,483 1/1/2008 1/1/2008 12/31/2011 12/31/2008 NIH 1629‐4 $163,169 $23,946 $329,042 $48,289 1/1/2008 1/1/2009 12/31/2011 12/31/2009 NIH 5k23hl004475‐05 $12,192 $975 $143,750 $11,500 9/5/2002 9/1/2006 8/31/2008 8/31/2008 NIH 1629‐5 $0 $0 $62,590 $29,417 7/1/2009 7/1/2009 6/30/2011 6/30/2011 Publications (Pulmonology) Journal Articles Donnelly DF, Bavis RW, Kim I, Dbouk HA, Carroll JL. Time‐course of alterations in pre‐ and post‐synaptic chemoreceptor function during developmental hyperoxia. Respir Physiol Neurobiol. 2009 May 22. Jambhekar S, Carroll JL. Diagnosis of pediatric obstructive sleep disordered breathing: beyond the gold standard. Expert Rev. Resp. Med. 2008 December; 2(6):791‐809. 86 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Kim D, Cavanaugh EJ, Kim I, Carroll JL. Heteromeric TASK‐1/TASK‐3 is the major oxygen‐sensitive background K+ channel in rat carotid body glomus cells. J Physiology 2009 April 29; 587(12):2963‐75. Kim I, Yang DJ, Donnelly DF, Carroll JL. Fluoresceinated Peanut agglutinin (PNA) is a marker for live O2 sensing glomus cells in rat carotid body. Adv Exp Med Biol 2009 648:185‐190. Kim JH, Kim I, Carroll JL. Modification of relative gene expression ratio measured by real time PCR using mathematical equations. Adv Exp Med Biol 2009 648:125‐135. Menendez A. Consultation indicates range of services available at UAMS/ACH Centers for Children. Pediatric Commentary. 2009 January; 18(1):10‐11. Morris MG. A novel physiological investigation of the functional residual capacity by the bias flow nitrogen washout technique in infants. Pediatr. Pulmonol. 2009 44:683‐692. Book Chapters Berlinski A, Carroll JL. Pediatric Respiratory Medicine. 2nd Edition ed. Elsevier Landau and Taussig eds.; 2008. Chapter 45. Eosinophilic lung diseases and hypersensitivity pneumonitis. Carroll JL, Donnelly DF. Sleep and Breathing During Sleep in Children: Developmental Approach. Marcus CL, Loughlin GM, Donnelly DF, Carroll JL ed. New York: Taylor & Francis, Inc.; 2008. Peripheral chemoreceptor maturation. Carroll JL, Kim I, Dbouk H, Yang DJ, Bavis RW, Donnelly DF. Time‐Dependence of Hyperoxia‐Induced Impairment in Peripheral Chemoreceptor Activity and Glomus Cell Calcium Response. Adv Exp Med Biol ed. Springer; April 2009. Chapter 299‐306. Gauda EB, Carroll JL, Donnelly DF. Arterial Chemoreceptors. Netherlands: Springer; 2009. Developmental Maturation of Chemosensitivity to Hypoxia of Peripheral Arterial Chemoreceptors û Invited Article. Kim I, Yang DJ, Donnelly DF, Carroll JL. Arterial Chemoreceptors. Adv Exp Med Biol ed. Springer; April 2009. Chapter Vol. 648, pg. 185‐190. Fluoresceinated Peanut Agglutinin (PNA) is a Marker for Live O2 Sensing Glomus Cells in Rat Carotid Body. Kim JH, Kim I, Carroll JL, Carroll J. Arterial Chemoreceptors. Adv Exp Med Biol ed. Springer; Apr 2009. Chapter Vol. 648 pg. 125‐135. Modification of Relative Gene Expression Ratio Obtained from Real Time qPCR with Whole Carotid Body by Using Mathema Books Clancey JP, Com G. Adenosine Receptors in Health and Disease, Handbook of Experimental Pharmacology 193. Springer‐Verlag Berlin Heidelberg ; 2009. Patents (Pulmonology) Issued Morris, Mohy G. 20090131811 Comprehensive Integrated Testing Protocol (CITP) for Infant Lung Function 87 Annual Report: 2008‐2009 | UAMS Department of Pediatrics National Professional Positions (Pulmonology) Editorial/Study Section Activities Carroll, John L. Arkansas Children's Hospital Research Institute ‐ CUMG grant reviewer, Grant Review, 2002‐present Medical Research Council of Australia (NHMRC) ‐ ad hoc grant reviewer, Grant Review, 2002‐present National Institutes of Health (NIH), Regular Member: Respiratory Integrative Biology and Translational Research (RIBT) Study Section, Grant Review, July 1, 2005 to June 30, 2009 National Institutes of Health (NIH), Specialized Centers of Research (SCOR)In Neurobiology of Sleep And Sleep Apnea And Airway Biology And Pathogenesis of Cystic Fibrosis. RFA: RFA‐HL‐02/013 National Heart, Lung, and Blood Institute Reviewer ‐ CSR Special Empasis Panel, Grant Review, 2003‐present Reviewer, NIH National Heart, Lung, and Blood Institute (NHLBI) Loan Repayment Program (L30). Member of the Special Emphasis Panel to review applications for the Extramural Loan Repayment Program (LRP) for Clinical Researchers (PA‐07‐442), and for Pediatric Researchers (PA‐07‐440), Grant Review, 2009‐present Reviewer, Thrasher Research Fund. Ad hoc invited research project reviewer., Grant Review, 2006‐present Social Studies and Humanities Research Council of Canada, ad hoc grant reviewer for the Canada Research Chairs Program. August‐September, 2009, Grant Review, 2009‐2009 Wellcome Trust (London), ad hoc project grant reviewer, Grant Review, 2004‐present Other National Professional Positions Bauer, Martin L. Pediatric Pulmonology Training Directors Association, Web Site Developer, 2008 ‐ present Berlinski, Ariel International Society for Aerosols in Medicine, Chair of Pediatric Networking Group, 2009 ‐ present Honors & Awards (Pulmonology) Bauer, Martin L. Jambhekar, Supriya Warren, Robert H. 88 D. Robert McCaffree, M.D., Master FCCP Humanitarian Award, The Chest Foundation, 2009 ‐ 2010 Best Doctors in America, 2008 Ruth Olive Beall Award, Arkansas Children’s Hospital, 2009 Annual Report: 2008‐2009 | UAMS Department of Pediatrics Rheumatology The Rheumatology Section provides 10 half day clinics at ACH in addition to a full day clinic at the Center for Children in Lowell every other month. Section members have a significant presence in the Day Medicine area as well. Physicians are available for inpatient consults and phone consultation with referring physicians. This past year has been a banner year for resident participation in the rheumatology elective. Thirteen residents spend time in the Section for a month or as part of the combo elective. Feedback from the residents is positive. Fellows from the adult rheumatology program at UAMS continue to attend clinic on a weekly basis. Section members developed a web CT pre‐ and post‐test which is taken by all learners which opened on July 1, 2008. Since initiation, the test has been greatly expanded, and the new and improved version will be available July 1, 2009. Section members serve as resident advisers, and Dr. Jason Dare is a ICM II preceptor. Dr. Dare also gives an annual board review lecture for residents. Dr. Morris and Dr. Dare were both successful in publishing an article in peer‐reviewed journals this year. Eight new clinical research projects are in the various stages of ramping up for patient enrollment. Faculty (Rheumatology) Clinical Educator Assistant Professor Dare, Jason A. Associate Professor Morris, Paula K. Grants (Rheumatology) Primary Investigator/ Project Title Awarded Morris, Paula A 12 Week Randomized Double‐Blind, Placebo Controlled, Paralle Group, 2 Arm Study to Evaluate the Efficacy and Safety of Tocilizumab in Patients with Active Systemic Juvenile Idiopathic Arthritis Compassionate Use Study of Adalimumab in Children 2 to < 4 YO or Age 4 and above weighing less than 15 kg with Active Juvenile Idiopathic Arthritis SINCERE: Safety in Idiopathic arthritis: NSAIDS and Celebrex Evaluation Registry A Prospective Observational Registry of Patients with JIA treated with NSAIDs Funding Agency Agency Award Number ‐‐‐Current Yr Annualized‐‐‐ Direct Indirect ‐‐‐‐‐‐‐‐All Years‐‐‐‐‐‐‐‐ Direct Indirect Roche WA18221 $27,653 $6,804 $110,308 Abbott M10‐444 $11,942 $3,583 $22,697 Pfizer SINCERE $38,058 $11,417 $76,746 $27,140 Project Dates Budget Year 5/8/2008 5/8/2009 4/29/2011 4/29/2011 $6,809 5/22/2009 5/22/2009 4/30/2010 4/30/2010 $23,024 5/1/2009 5/1/2009 4/30/2010 4/30/2010 Publications (Rheumatology) Journal Articles Dare JA, Jahan S, Hiatt K, Torralba KD. Reintroduction of Etanercept During Treatment of Cutaneous Mycobacterium Marinum Infection in a Patient With Ankylosing Spondylitis. Arthritis Rheum 2009 May 15; 61(5):583‐6. Morris P, Herrera‐Guerra, AA, Parham D. Lymphoma Arising from a Calcinotic lession in a patient with Juvenile Dermatomyositis. Pediatric Dermatology 2009 Mar‐Apr; 26(No 2):159‐161. 89 Annual Report: 2008‐2009 | UAMS Department of Pediatrics National Professional Positions (Rheumatology) Editorial/Study Section Activities Dare, Jason A. CUMG Review Committee, Grant Review, 2008 Honors & Awards (Rheumatology) Morris, Paula K. Arkansas Times "Best of the Best," Best Rheumatologist, 2008 Best Doctors in America, 2009 Best Doctors in America, 2008 Honorary Chairman of 2008 Arthritis Walk, Arkansas Arthritis Foundation, 2008 Schmieding Developmental Center The Schmieding Developmental Center located at the Centers for Children in Lowell has made good strides in rebuilding and adding evaluation and medical follow up capacity. During this fiscal year, there was continued focus on Autism Spectrum Disorders and addition of high‐risk newborn clinics. Developmental Pediatrics sent a physician on a monthly basis to help identify needs in following infants and toddlers. Advancements have been made in the assessment of learning problems and the Center developed a Dyslexia intervention program that the pediatric community has been requesting for some time. The Schmieding Developmental Center has also added a Behavioral Health Psychologist giving the Center the ability to design psychological treatment programs for the impact chronic medical conditions have on emotional function and non‐compliance with medical treatment. The recruitment of a Reading Specialist has allowed for the development of the Reading Clinic and increased learning disability assessment for children not responding to traditional educational models. Clinics have been added as needed to support the referral needs of Pediatric Neurology, now on site, and Pulmonology at the Centers for Children in Lowell for developmental evaluation and behavioral consultation. Educational programs have advanced with the initial development of a more formal evaluation process for medical students and the supervising physicians/clinicians rotating through from the AHEC Program has been established. This will allow for increased involvement in teaching. Finally, some clinical research opportunities are being explored and will be made more possible by the recruitment of a more active clinical researcher. Faculty (Schmieding Developmental Center) Clinical Attending Clinical Assistant Professor Adkisson, Jarrod R. Duncan, Christina L. Shumate, Linda Young Clinical Associate Professor Scott, Mary Ann Publications (Schmieding Developmental Center) Journal Articles Duncan C, Wu Y, Sato A. Pediatric psychology: Crossing the lines of psychology and medicine. The Next Generation: An Introduction to Medicine 2009 April; 5(3) 90 Annual Report: 2008‐2009 | UAMS Department of Pediatrics National Professional Positions (Schmieding Developmental Center) Editorial/Study Section Activities Duncan, Christina L. Rehabilitation Psychology, Editorial Board 2007‐2009 Journal of Pediatric Psychology, Editorial Board, 2003‐2009 Behavior Therapy, Editorial Board,1997‐2009 Other National Professional Positions Duncan, Christina L. American Psychological Association, Division 54, Secretary, 2007 – 2012 91 Annual Report: 2008‐2009 | UAMS Department of Pediatrics

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