Download 4 Proposal BSc Programme in pharmacology (Final).

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DEPARTMENT OF PHARMACOLOGY
FACULTY OF BASIC MEDICAL SCIENCES
UNIVERSITY OF CALABAR
CALABAR-NIGERIA
PROPOSAL FOR B.SC DEGREE PROGRAMME IN PHARMACOLOGY
1. Philosophy and Objectives of the Degree Programme
1.1 Philosophy
Pharmacology provides the knowledge of drugs actions and their
effects in the treatment of diseases as well as development of
new pharmaceutical products for improved health care system.
This knowledge covers Pharmacokinetics, Pharmacodynamics and
fate of drugs in biological system.
The Bachelor Degree Programme in Pharmacology will produce
graduates at the middle level manpower in the areas of drug
research and development who are competent to fill in the gaps
in the pharmaceutical industry, research institutions, and as
trainers in the medical schools, schools of nursing and allied
health sciences.
1.2 Objectives
The objectives of the B.Sc. Programme are:
1.
To teach and apply Pharmacological concepts required in
the future clinical practice of doctors in both rural and
urban areas of Nigeria and any other part of the world.
2.
To teach and give students scientific foundation for
continued study and research in Pharmacology so as to
help in producing specialists in Pharmacology.
3.
To train students to design and carry out research in the
field of Pharmacology and to interpret scientific data
generated from experimental procedures while making
use of statistical concepts.
4.
To produce quality manpower needed in pharmaceutical
industries, Universities and especially Schools of Medicine
and Allied Health Sciences in Nigeria and other countries
of the world.
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2. Admission, Duration of Study and Graduation
Requirements
2.1 Admission requirements
The entry qualifications for the four-year Degree Programme of
Bachelor of Science (Hons.) in Pharmacology are as follows: West
African School Certificate, General Certificate of Education, NECO,
or equivalent with credits in English Language, Chemistry,
Physics, Biology or Biological Sciences, Mathematics.
3. Duration of Study and Graduation Requirements
The normal duration for the Bachelor’s Degree in Pharmacology is
four academic sessions of eight semesters while the maximum
period shall be 50% above the number of academic session. To
be eligible for the award of a Bachelor of Science Degree, a
student must obtain a minimum of 90 Credit Units in the threeyear programme, inclusive of the university course requirements.
4. Organization of the Programme
A programme of study is provided leading to a Bachelor of
Science (B.Sc) degree in Pharmacology which may be awarded as
Honours or as Pass degree. Instruction for the programme is
organized in courses and each student is required to register for
not less than 18 credit units and not more than24 credit unit per
semester. Each course is normally assigned 3 credit hours. There
are four levels of course organization numbered as follows:
100 - 199
200 - 299
300 – 399
400 - 499
The first digit indicates year of study, the middle digit indicates
area of study while the last digit indicates the semester in which
the course is offered. The course numbers are prefixed by a three
character discipline code, indicating the department in which the
course is domiciled e.g. ANA, BCM, PHS, PHM for Anatomy,
Biochemistry, Physiology, Pharmacology respectively.
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5. B.Sc. Courses in Pharmacology
Year One
Course Details
First Semester
Course No.
Course Title
Credit Unit
BIO 111
General Biology 1
3
PHY 101
General Physics 1
3
CHM 111
General chemistry I
3
MTH 111
Elementary Mathematics I
3
GSS 101
Use of English
2
GSS 131
History and philosophy of Science 2
16
Second Semester
Course No.
BIO 112
PHY 112
CHM 122
GSS 102
GSS 112
GSS 122
PHM 101
Year Two
First Semester
Course No.
ANA 221
PHS 211
PHS 221
PHS 231
BCM 221
BCM 211
GSS 211
MCB 211
Course Title
Credit Unit
General Biology II
3
Introductory physics II
3
General Chemistry II
3
Use of English
2
Nigerian Heritage
2
Philosophy and Logic
2
History and Scope of Pharmacology 3
18
Course Title
Credit Unit
General Anatomy and gross
anatomy of upper and lower limbs 3
Physiology of Excitable Tissues
3
Blood Physiology
3
Cardiovascular System
3
Chemistry of Bio-molecules
2
Physical Biochemistry and
Analytical Methods
3
Introduction to Computers
2
General Microbiology
3
22
6
Second Semester
Course No.
Course Title
Credit
ANA 231
General Embryology, Embryology
of Body Cavities and Introduction
to Medical Genetics
BCM 242
Chemistry & metabolism of Lipids
Steroids and Biological Pigments
BCM 252
Chemistry & metabolism of
proteins & Amino acids
BCM 262
Chemistry & Metabolism of
Nucleic Acids
PHS 262
Renal Physiology, Body Fluids
and Temperature Regulation
PHS 272
Respiratory System
PHM 222
Anatomical Basis for Drug Actions
GSS 212
Computer Application
Year Three
First Semester
Course No.
PHM 301
PHM 331
PHM 341
PHM 351
PHM 361
PHM 371
PHM 381
GSS 301
PHS 321
Course Title
Credit
General Principles of Pharmacology
Pharmacokinetics & Pharmacogenetics
ANS-Parasympathetic Mechanisms
ANS-Sympathetic Mechanisms
Neuropharmacology
Pharmacology of the Organ Systems
Practical
Entrepreneurship - 1
Endocrinology & Reproduction
Unit
3
3
3
3
3
2
3
2
21
Unit
2
2
2
2
3
3
4
2
2
22
7
Second Semester
Course No.
Course Title
Credit
PHM 312
Endocrine & Reproductive System
Pharmacology
PHM 342
Vitamins and Nutritional Haemopoietic
Agents
PHM 352
Toxicology
PHM 362
Experimental Methods in Toxicology
PHM 372
Chemotherapy of Tropical Diseases,
Antiseptics & Disinfectants
MCB 312
Microbial Genetics & Molecular Biology
PHS 372
Special Senses IT
PHS 382
Laboratory Teaching & Instrumentation
GSS 302
Entrepreneurship - 2
Year Four
First Semester
Course No.
PHM 411
PHM 421
PHM 431
PHM
PHM
PHM
PHM
441
451
461
471
PHM 481
PHM 491
PHM 401
Course Title
Credit
Chemotherapy of Microbial
Diseases, Vaccines and Sera
Chemotherapy of Neoplastic Diseases,
Anti-neoplastics
Immunopharmacology: Pain,
Inflammation, Anti-inflammatory agents
Practical on all 400 level courses
Psychopharmacology
Ethnopharmacology
Care of Laboratory Animals and
Laboratory management
Environmental Toxicology
Principles of Therapeutics,
Drug Prescription & dispensing
Quantitative Pharmacology
Unit
2
2
3
1
3
2
3
2
18
Unit
2
1
2
4
1
2
2
2
2
3
21
8
Second Semester
Course No.
PHM 412
PHM 422
PHM 462
Course Title
Seminars in Pharmacology
Pharmacokinetic Principles
Projects in Pharmacology
Credit Unit
4
3
9
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COURSE DESCRIPTION
BIO 111
General Biology I (3 Units)
This is an introductory Biology course which is designed to give
the student a background into the general tenets of animal and
plant Biology, cell structure and organization, diversity,
reproduction, inter-relationship of organism, heredity, evolution
and elements of ecology.
BIO 112
General Biology II (3 Units)
The course is intended to give a comparative study of the major
morphological characteristics of the different plant and animal
groups, showing the gradual evolution from lower to higher
organisms. The ecological adaptations of the different groups of
plants and animals will be studied.
MCB 211
General Microbiology I (3 Units)
Historical
aspects,
scope
of
microbiology,
general
characcteristiecs of microorganisms, growth and reproduction,
sterilization and disinfection, brief survey of microbes as friends
and foes.
MCB 312 Microbial Genetics & Molecular Biology (2 Units)
The course covers basic a survey of the concepts of microbial
genetics (bacteria, viruses, protozoa and fungi) including
discussion of methods and findings in the areas of mutagenesis,
inductions, isolation and biochemical characterization of mutants,
adaptation, transformation, transduction and conjugation.
General and specialized methods and techniques in microbial
genetics. Pre-requisite.
PHS 211 Physiology of Excitable Tissues (3 Units)
Introduction to Physiology and its place in medicine, the
composition of cell, cell membrane and transport mechanism,
membrane potentials, Physiology of excitable tissues, types of
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ionic channels, cell signaling, introduction to patch clamp
technique.
PHS 221
Blood Physiology (3 Units)
Compartmentalization and composition of body fluids, general
characteristics and functions of blood, properties and functions of
plasma, red blood cells, factors involved in erythropoiesis, blood
groups, white blood cells, origin, types, properties, functions,
antigenicity and immunities, platelets and hemostatic mechanism,
reticuloendothelial system, clotting and fibrinolytic system,
human immunodeficiency virus (Acquired Immune Deficiency
Syndrome HIV/AIDS), pathophysiology, test, physiology of stem
cells and cloning.
PHS 231
Cardiovascular System (3 Units)
Overall plan and functions of the cardiovascular system,
physiological anatomy of the heart, mechanical events of cardiac
cycle, cardiac output and its estimation, electrocardiogram, the
vascular system gross sectional area of different vascular groups,
systolic diastolic pulse and mean arterial pressure, exchange of
fluids across the capillaries, venous and central venous pressures,
integration of cardiovascular functions, central control centers,
regulations
of
systemic
blood
pressure,
cardiovascular
adaptations in health and disease, circulation through special
areas.
PHS 262 Renal Physiology, Body Fluids and Temperature
Regulation (2 Units)
The skin: Functional anatomy, temperature regulations,
abnormalities of temperature regulation, Metabolism, factors
regulating metabolism, conditions for measuring basal metabolic
rate, Physiologic anatomy of the kidney, renal circulation and
autoregulation, Glomerular filtration, Tubular transport, Urine
formation, counter-current system, Water volume and ionic
regulation, Acid-base balance, Micturition, Abnormalities of renal
function, Recent advances in renal physiology.
PHS 272
Respiratory System
(2 Units)
Physiologic anatomy of respiratory apparatus, brief review of
relevant gas laws, lung volumes, mechanics of breathing, gas
diffusion through alveoli capillary membrane, pulmonary
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circulation, ventilation perfusion ratio, oxygen and carbondioxide
transport control of respiration, hypoxias, oxygen treatment,
abnormal types of breathing, attitude and depth, acclimatization,
respiratory adjustments in health and disease.
BCM 221
Chemistry of Biomolecules (2 Units)
Chemistry,
structure
and
properties
of
carbohydrates.
Classification of carbohydrates. Steerio and optical isomerism in
carbohydrates. Polysaccharides including mucopolysaccarides and
cell wall polysaccharides. Test for carbohydrates. Biological
importance of carbohydrates. Chemistry and classification of
lipids properties and structure. Fats fatty acids, waxes, steroids,
phospholipids, glycosphingosides, sulfolipids, proteolipids and
steroids. General properties of proteins, classification of proteins
chains (primary, secondary, tertiary and quaternary structures).
Colour reactions of proteins and amino acids. Chemistry and
properties of nucleic acid. Purines and pyrimidine bases.
Nucleosides, nucleotides and nucleic acid structures. Types and
functions of the RNAs. Genome organization. Nucleoproteins.
Vitamins and co-enzymes. Plant growth factors
BCM 231 Physical Biochemistry and Analytical Methods
(3 Units)
Gases, solutions, equilibrium and dissociation constants.
Hydrogen ions concentration and the pH, acids, bases and
buffers. Osmotic pressure: The biochemical importance of pH.
Methods of expressing concentrations. Bonds and interactions.
Introduction to the principles and applications of some commonly
used biochemical techniques (colorimeter, chromatography,
electrophoresis, centrifugation, spectrophotometry, spectroscopy
and manometary)
BCM 242 Chemistry & metabolism of Lipids Steroids and
Biological Pigments (3 Uints)
Chemistry and classification of lipids. Properties and structures of
fatty acids, waxes, steroids, phospholipids, glycophingosides,
fulfolipids and steroids. Digestion and absorption of lipids. Blood
lipid (including lipoproteins). Synthesis and degradation of fatty
acids (including oxidation of fatty acids). Fatty acid
intercinversion. Prostaglandins. Disorders of lipid metabolism.
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BCM 252 Chemistry & metabolism of proteins & Amino
acids (3)
General properties of proteins, classification of proteins and
amino acids, properties of amino acids. Synthesis of peptides.
Methods for separating and determination of amino acids and
peptides. Amino acids sequence and organization of protein
chains (primary, secondary, tertiary and quaternary structures).
Colour reactions of proteins and amino acids. Digestion,
absorption and metabolism of proteins and amino acids.
Metabolism of individual amino acid. One-carbon unit. Protein,
synthesis (including the involvement of the RNAs). Urea cycle.
Disorders of protein and amino acid metabolism.
BCM 262 Chemistry & Metabolism of Nucleic Acids (3 Units)
Chemistry and properties of nucleic acids. Purines and pyrimidine
bases. Nucleosides, nucleotides and nucleic acids structure and
synthesis, isolation of nucleic acids, hydrolysis of nucleic acids.
Primary and secondary nucleic acid (including methods of
determination). Types and functions of RNAs. Genome
organization. Nucleoproteins. Metabolism of purines, nucleotides
and nucleosides and nucleotides. Macromolecules in eukaryotic
cell. Abnormalities in nucleic acids metabolism. Xeroderma
pigmentation and skin cancer.
ANA 231
General Embryology, Embryology of Body
Cavities and Introduction to Medical Genetics
Introduction to the developing human, developmental periods,
significance of embryology. Description of terms in embryology.
Germ cell and gametogenesis (permatogenesis/oogenesis), femal
reproductive cycles (menstrual and ovarian cycles). Structure of
ovum, ovulation and its role in family planning. Fertilization
cleavage, formation of the blastocyst. Formation of germ layers,
formation of neural tube and notochont, development of somiltes.
Development and subdivisions of intraembryuonic mesoderm and
coelon, development of placenta and abnormalies. Further
development of embryonic disc. Folding of embryo. Formation of
the tissues of the body and derivatives of germ layer. Formation
of embryonic cavity, serous membrane, diaphragm and thoracic
cavity. Introduction and definition of genetics. Role of genetics in
the practice of medicine. Definition and structure of chromosome,
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classification of chromosomes and the role DNA in genetics.
Anormalies of autosomal and sex chromosome structures, gene
mutation and diseases.
ANA 222 Histology of Cardiovascular System, Immune &
Urogenital Systems and its appendages
(2 Units)
Histology of arteries, arterioles, veins, venules, capillaries,
sinusoids, heart lymphatic vessels, lymph nodes, spleen and
thymus, kidney, ureters, urinary bladder and wethra. Gonads
(ovary and testis) and accessory urogenital organs (epodidymis,
vasodeferens,seminal vesicles, prostate gland, penis and clitoris).
Skin and its appendages (hairs, glands, nails, sweat glands).
PHM 301 General Principles of Pharmacology
(2 Units)
Introduction: History of Pharmacology and relationship to other
Pharmaceutical and clinical subjects. Pharmacology Textbooks
and Journals. Definition and sources of Drugs. Routes of Drug
Administration. Drug Absorption, Distribution, Elimination and
factors affecting them. Drug metabolism and factors affecting.
Enzyme induction and enzyme inhibition. Mechanisms of drug
action – Receptor and non-receptor theory. Drug dosage and
dose-response curves. Measurement of some pharmacological
parameters.
PHM 331 Pharmacokinetics & Pharmacogenetics (2
Units)
Pattern of transmission of single gene trait. Hardy-Weinberg Law,
conditions for its validity, application. On concepts of continuous
and discontinuous variation. Pharmacogenetics (drug metabolism,
tissue metabolism and receptor alterations). Compartment
models (one and two), kinetics after i.v. and oral dosing.
Bioavailability, Drug distribution, Protein binding, Renal excretion
of drugs. Urinary excretion data in Pharmacokinetic analysis.
PHM 341 ANS-Parasympathetic Mechanisms
(2 Units)
Autonomic Pharmacology Cholinergic
(Parasympathetic)
Mechanisms
Theory of chemical neuro-transmitters – Evidence of acetylcholine
as a cholinergic neuro-transmitter. Detection and bioassay of
acetylcholine. Cholinergic receptors, sites of action of
acetylcholine at the neuromuscular junction. Agonists and
antagonists of cholinergic transmission. Parasympathomimetic
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and
parasympatholytic drugs.
Cholinesterase
and
anticholinesterases. Properties and use of anticholinesterases.
Neuromuscular transmission and drugs which.
PHM 351 ANS-Sympathetic (Adrenergic) Mechanisms (2
Units)
Theory of chemical neuro-transmitter – Evidence to noradrenaline
as an adrenergic neuro-transmitter. Synthesis, storage, release,
metabolism and uptake of catecholamines. Detection and
Bioassay of Adrenaline and Nor-adrenaline. Adrenergic receptors
– Types of Adrenoceptors. Concept of agonists and antagonists.
Sympathomimetic amines – Catecholamines, properties and uses.
Sympatholytic drugs (Adrenergic blockers), properties and uses.
Structure-activity relationships among the sympathomimetic
amines and beta-adrenergic blockers.
PHM 361
Neuropharmacology (3 Units)
CNS Depressants and Stimulants: Hypnotics, Sedatives,
Tranquilizers, Anticonvulsants and related disorders, Anxiolytic
drugs, Tricyclic antidepressants, other CNS stimulants and
analeptics.
Centrally
acting
appetite
suppressants.
Antiparkinsonism drugs. Narcotic and Non-narcotic analgesics.
General and local anaesthetics.
PHM 371 Pharmacology of the Organ Systems
(4 Units)
Cardiac muscle physiology. Cardiac glycosides. Anti-hypertensive
drugs. Anti-arrhythmic drugs. Anti-angina drugs. Anti-obesity
drugs. Anti-lipidaemic drugs. Respiratory stimulants. Antitussives and Expectorants. Drugs in asthma. Bronchitis and
Pneumonias. Renal physiology and Diuretics. Anti-diuretics and
anti-uricaemic drugs. Drugs in urinary tract infections. GIT
Physiology. Anti-ulcer drugs. Emetic and Anti-emetics. Purgatives
and Laxatives. Antidiarrhoea. Anti-spasmodic drugs. Digestants.
Drugs acting on the uterus.
PHM 381 Practicals on PHM 301, 331 – 371 (2 Units)
Selected practical to illustrate the theoretical principles
PHM 312 Endocrine & Reproductive System Pharmacology
2 Units
Thyroid and Anti-thyroid drugs. Parathyroid and Calcitonin.
Anterior pituitary hormones and related hormones. Insulin and
oral hypoglycaemic agents. Oestrogens and progesterone. Oral
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contraceptives and Fertility agents. Androgen and Anabolic
steroids.
PHM 342 Vitamins & Nutritional Haemopoietic Agents (2
Units)
Water soluble vitamins I. Water soluble vitamins II. Fat soluble
vitamins I. Fat soluble vitamins II. Drugs effective in iron
deficiency of anaemias and other hypochromic anaemias. Drugs
in the treatment of Megaloblastic and Pernicious anaemias.
Antithrombotic and Thrombotic agents. Management of
haemorrhage.
PHM 352
Toxicology
(3 Units)
Introduction. Origin and scope of Toxicology. Introduction to
laboratory methods. Toxicological evaluation. Purpose and value
of ED50 and LD50 determination. Metabolism of some toxic
substances. Pesticides. Insecticides. Cyanides.
Teratology.
Carcinogens. Systemic toxicology. Cosmetics testing. Clinical
toxicology. Poisoning and antidotes. Management of drug
poisoning. Environmental pollution. Industrial toxicology and Food
additives. Forensic toxicology.
PHM 362
Methods in Toxicology (1 Unit)
Practical 1& 2: ED50 and LD50 Determination
Practical 3: Acute and chronic poisoning in rabbits (or rats)
Practical 4: Antidotes
Practical 5: Cosmetic testing
Practical 6: Identification of drugs by Thin Layer Chromatography
(TLC)
Practical 7: TLC Experiment (contd.)
Practical 8: Experimental procedures for analysis of toxicological
agents. Use of U.V, I.R., NMR, TLC, HPLC for qualitative and
quantitative assay
PHM 372
Chemotherapy of Tropical Diseases
(2 Units)
Life cycle of malaria parasite. Life cycle of Entamoeba histolytica.
Drugs used in the treatment of malaria, Amoebiasis,
Trypanosomiasis, Leishmaniasis, Helthminthiasis.
Antiseptics & Disinfectants (1 Unit)
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PHM 411 Chemotherapy of Microbial Diseases, Vaccines
and Sera (2 Units)
Antibacterials/Antibiotics: The sulphonamides and trimethoprim.
The
Penicillins
and
Cephalosporins.
Tetracyclines
and
Chloramphenicol. The Aminoglycosides. The Macrolides, etc.
Miscellaneous Antimicrobials, Polypeptides. Antifungal and
Antiviral agents. Drugs used in the treatment of Tuberculosis and
Leprosy. Vaccines and Sera.
PHM 421 Chemotherapy of Neoplastic Diseases: Antineoplastics (1 Unit)
Alkylating Agents, Antimetabolites, Hormones. Other antineoplastic agents: Antibiotics, Plant alkaloids and miscellaneous
agents.
PHM 431 Immunopharmacology: Pain, Inflammation, Antiinflammatory agents (2 Units)
Introduction:
Definition,
Types,
Characteristics
and
pathophysiology of pain, inflammation and anaphylaxis.
Experimental models and screening techniques for analgesics and
anti-inflammatory agents. Non-steroidal anti-inflammatory drugs.
Evaluation of analgesic activity of drugs, Hot-plate method. Antiinflammatory drugs useful in gout.
Vasoactive peptides that mediate pain:
i) Kinins, substance compound 4840 etc.
ii) Angiotensin
iii) Prostaglandins
Pathophysiology of allergic and immune reactions
PHM 441 Practicals on all 400 level courses (4 Units)
Methodology in evaluation of chemotherapeutic agents.
Determination of therapeutic indices. Isolated Tissue and Whole
Animal Experiments as in Laboratory Manual
PHM 451 Psychopharmacology (1 Unit)
History
of
Psychopharmacology.
Developmental
Psychopharmacology. Blood Brain Barrier and other membrane
phenomenal
in
Psychopharmacology.
Nutritional
Psychopharmacology.
Behavioral
Pharmacology
of
CNS
Stimulants. Drug abuse and drug addiction. Clinical uses of
psychotherapeutic agents. Toxicology of psychotherapeutic
agents.
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PHM 461
Ethnopharmacology (2 Units)
1. Definition, historical and religious basis of ethnomedicine – The
medicine of Avicena, Asculapius and Galen. Traditional medicine
in folklore of Calabar bean. South American arrow poison, Coca
chewing and opium poppy smokoing of the American Indians, etc.
2. Race and cultural influence of traditional medicine. Herbal
medicine and orthodox medicine – Homeopath, Naturepath,
Chinese ocupuncture, African medicine.
3. Socio-economic, politico-religious and technological influence
on drug development and medical practice.
4. Important plant and animal sources of modern medicine from
Belladona to digitalis, from cinchona bark to opium poppy.
5. Scientific methods of evaluation of herbal preparations.
6. Desirability or not of merging orthodox and traditional medical
practices.
7. The African pharmacopoeia.
PHM 471 Care of Laboratory Animals and Laboratory
management (2 Units)
Students will instructed in accordance with information contained
in (i) Pharmacology Laboratory Manual of the Department of
Calabar, Calabar and (ii) Guidelines on the Care of and Use of
Animals for Scientific Research Purposes of the Faculty of Basic
Medical Sciences, University of Calabar, Calabar. Care of
laboratory animals. Breeding of different laboratory animals.
PHM 48 Environmental Toxicology (2 Units)
Introduction to toxicology, definition of terms, branches of
toxicology. Environmental toxicology. Global Impacts. Air, Water
and Soil Pollutions. Stratosphere ozone depletion. Effects of
ozone depletion. Prevention of pollution. Industrial pollutions –
Heavy metals poisoning and drug treatment. Chelating agents.
PHM 491
Principles of Therapeutics, Drug Prescription &
dispensing (2 Units)
Therapy as a Science. Individualization of drug therapy.
Pharmacokinetic and Pharmacodynamic considerations. Other
factors that affect therapeutic outcome – Age, Drug-drug
interactions, Fixed-dose considerations, Placebo effects, Genetic
factors. Drug prescription and dispensing. Calculation of dose.
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T1/2, Therapeutic index, etc. Dosage regime. Side effects of
drugs. Adverse drug reactions.
PHM 401
Quantitative Pharmacology (3 Units)
Introduction. (i) Drug-drug interactions - Affinity and intrinsic
activity, Occupancy theory, Rate theory. (ii) Drug-receptor
interactions – Law of mass action, Enzyme substrate interaction.
Dose-response relationships. (iii) Law of mass action and
Derivation of affinity, PD2. (iv) Competitive antagonism. The
Gaddum-Schild Equation for Affinity constant of competitive
antagonists. (v) Non-competitive antagonism. Pharmacodynamic
prediction from pharmacokinetic data (One compartment model).
Receptor
desensitization.
Mechanisms
of
post-receptor
transduction.
(vi) Introduction to Biostatistics. Normal distribution, Mean, Probit
transformation, Standard deviation and Standard error. T-test Paired and Unpaired. Chi-square Test. Analysis of variance,
poison distribution.
PHM 412 Seminars in Pharmacology (4 Units)
Students are expected to attend all Departmental and Faculty
Seminars. Each student will be given topics to work on, writ up as
well as present during seminars.
PHM 422 Pharmacokinetic Principles (3 Units)
Introduction – Mathematical basis of time course of ADME. Rates
of reaction - Zero-order reaction, First-order reaction.
Pharmacokinetic models – One-compartment model, Two –
compartment model, Multi-compartment model. Pharmacokinetic
parameters – Elimination rate constant, Volume of distribution,
Half-life, Clearance. Pharmacokinetic applications – Single IV
administration, Multiple doses, Intravenous infusion, Single oral
dose, Multiple oral dose. Calculations.
PHM 462 Projects in Pharmacology (9 Units)
Experimental research project on a topic of interest to be
supervised by a qualified Academic Staff.
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STAFF OF THE DEPARTMENT
Academic Staff
1. Prof. Francis V. Udoh
2. Dr. B. A. S. Lawal
3. Dr. Pius M. Udia
4. Dr. (Mrs.) Grace A. Essiet
5. Dr. Augustine D. Essien
6. Mr. Eban Linus Kechi
7. Mr. Takem Lapah Pierre
Diploma
in
Pharm.,
M.Sc.,
Ph.D.(Calabar). HOD
B.Sc.(Hons.),
M.Sc.,
Ph.
D.
(Lagos). Senior Lecturer
B.Sc.
(Hons.),
M.Sc.,
Ph.D.
(Calabar). Senior Lecturer
MBBCh.,
M.Sc.;
MPH,
Ph.D
(Calabar).Snr. Lecturer
MD.
(Minsk.),
M.Sc.
Ph.D
(Calabar). Senior Lecturer
HND, PGD, M.Sc. Lecturer 1I.
B.Sc.
(Hons),
M.Sc.
Assist.
Lecturer
Other Academic Staff
8. Dr. A. O. Igiri
B.Sc. (Hons), M.Sc., Ph.D. Reader
Anatomy
9. Prof. M. U. Eteng
B.Sc
(Hons),
Ph.D.
Professor
Biochemistry
10. Prof. D. U. Owu.
B.Sc. (Hons), M.Sc., Ph.D. Professor
Physiology.
11. Prof. S. P. Antai
B.Sc. (Hons), M.Sc. Ph.D. Professor
Microbiology
of
of
of
of
Technological Staff of Pharmacology Department
12. Barr. G. E. B. Inyang
HND (Animal Science), LL.B., BL.
M.Sc. (Law) - Chief Animal Health
Technologist
13. Mr. Marcus S. Inyang
HND (NIST), ANIST, MIST, PGD Chief Technologist
14. Mr. Isaac A. Onoko
HND (NIST), ANIST - Chief
Technologist
15. Mr. Etim Inyang Ifang
FSLC, WAEC – SNR Lab. Attendant
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Administrative Staff of Pharmacology Department
15. Mr. Michael U. Elijah
HND (Sect. Duties), MCSR – Chief
Confidential Secretary
16. Mrs. Affiong Udo Udo
FSLC – Caretaker
APPENDIX
Committee Members: B.Sc.
Pharmacology
1. Dr. Pius Monday Udia
2. Mr. Takem Lapah Pierre
3. Prof. Francis V. Udoh
4. Dr(Mrs) Grace A. Essiet
Degree Programme in
Chairman
Secretary
Member
Member