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European Journal of Clinical Pharmacology Volume 64 • Number 9 • September 2008 OBiTUARY PHARMACOKINETICS AND DISPOSITION Professor Dr. Nina Bakracheva RA. Thiirmann ■ E. Gatchev • U. Fuhr • S. Harder 835 Plasma esterases and inflammation in ageing and frailty RE. Hubbard ■ M.S. O'Mahony ■ B.L Calver ■ K.W. Woodhouse 895 EDITORIAL COMMENTARY Investigation of the in vivo activity of CYP3A in Brazilian volunteers: comparison of midazolam and omeprazoEe as drug markers A. Rocha ■ E.B. Coelho ■ S.A.P. Moussa ■ V.L. Lanchote 901 Cytochromes P450, induction and cholesterol—what are the connections? 0. Pelkonen ■ J. Hakkola 837 REVIEW ARTICLES Cytochrome P450 and gene activation—from pharmacology to cholesterol elimination and regression of atherosclerosis P.V. Luoma 841 Efficacy of pregabalin and gabapentin for neuropathic pain in spinal-cord injury: an evidence-based evaluation of the literature T.G.Tzellos ■ G. Papazisis ■ E. Amaniti ■ D. Kouvelas 851 PHARMACODYNAMICS Slower onset of vasodilating action of brain natriuretic peptide (BNP) compared to atrial natriuretic peptide (ANP) in human forearm resistant vessels H. Minami-T.Yasu -T.Tagawa- K. Yamakawa ■ S. Ueda 859 Influences of levodopa on adipose tissue and skeletal muscle metabolism in patients with idiopathic Parkinson's disease F. Adams ■ M. Boschmann ■ E. Lobsien ■ A. Kupsch ■ A. Lipp ■ G. Franke ■ M.C. Leisse ■ J. Janke ■ S. Gottschalk ■ J. Spranger ■ J.Jordan 863 PHARMACOGENETICS Genetic polymorphism of CYP1A2 and the toxicity of leflunomide treatment in rheumatoid arthritis patients P. BohanecGrabar ■ B. Rozman -M.Tomsic- D. Suput ■ D. Logar-V. Dolzan 871 Systemic exposure of the parent drug oxaliplatin during hyperthermic intraperitoneal perfusion H. Mahteme ■ I. Wallin ■ B. GSimelius • L Pahlman ■ H. Ehrsson 907 PHARMACOEPIDEMIOLOGY AND PRESCRIPTION Antibiotic drug use of children in the Netherlands from 1999 till 2005 J. de Jong ■ P.B. van den Berg ■ T.W. de Vries ■ LT.W.de Jong-van den Berg 913 Incidence and risk factors for agranulocytosis in Latin American countries—the Latin Study N. Hamerschlak ■ E. Maluf ■ A. Biasi Cavalcanti ■ A. Avezum Junior ■ J. Eluf-Neto ■ R. Passeto Falcao ■ I.G.H. Lorand-Metze ■ D. Goldenberg ■ C. Leite Santana ■ D. de Oltveira Werneck Rodrigues ■ L. Nascimento da Motta Passos ■ E.O. de Miranda Coelho ■ M.C.Tostes Pintao ■ H.M. de Souza ■ J.R. Borbolla ■ R. Pasquini 921 LETTERS TO THE EDITORS Contrast-media-induced hypersensitivity or allergic/ allergic-like reactions? Suggestion for a more appropriate use of the nomenclature [.Bohm-H.Schild 931 "Allergic-like/allergic" or "hypersensitivity" reactions? An open debate on ADR terminology F. Lapi ■ A. Mugelli ■ A. Vannacci 933 CYP3A4*1G polymorphism is associated with lipid-lowering efficacy of atorvastatin but not of simvastatin Y. Gao-L-r. Zhang- Q . F u 877 Enantiospecific pharmacokinetics of metoprolol in CYP2D6 ultra-rapid metabolizers and correlation with exercise-induced heart rate A. Seeringer ■ J. Brockmoller ■ S. Bauer ■ J. Kirchheiner 883 VK0RC1 and CYP2C9 polymorphisms are associated with warfarin dose requirements in Turkish patients G. OnerOzgon ■T.Y. Langaee ■ H. Feng ■ N. Buyru -T. Ulutin A.C. Hatemi ■ A. Siva ■ S. Saip ■ J.A. Johnson 889 Further articles can be found at www.springerlink.com Indexed in/abstracted by Current Contents and Index Medicus. Instructions for Authors for EurJCiin Pharmacol are available at www.springer.com/00228.