Download PHS 398 (Rev. 06/09), Continuation Page

BIOGRAPHICAL SKETCH
NAME
POSITION TITLE
Eric Pearlman, Ph.D.
Professor
eRA COMMONS USER NAME
EPEARLMAN
EDUCATION/TRAINING
INSTITUTION AND LOCATION
DEGREE
University of Glasgow, Scotland
Hebrew University of Jerusalem, Israel
University of Texas, San Antonio, TX
Case Western Reserve University, Cleveland, OH
B.S.
M.S.
Ph.D.
Post-doctoral
fellowship
A.
YEAR(s
)
1978
1981
1988
19881992
FIELD OF STUDY
Parasitology
Microbiology
Microbiology
Immunology
Personal Statement.
Studies in my laboratory are aimed at understanding the host response to fungal and bacterial infections
of the cornea, which cause blindness and visual impairment worldwide. We have been examining the
host response to the common filamentous soil fungi Aspergillus fumigatus and Fusarium species, which
are major causes of trauma related keratitis worldwide using mouse models of infection and examining
infected patients in south India. We have also been examining the pathogenesis of Pseudomonas
aeruginosa keratitis, focusing on innate immunity and on the role of Type III secretion proteins as
virulence factors. As with fungal keratitis, we are examining both human disease (in India) and animal
models.
B. Positions and Honors.
Positions and Employment
1992-1994 Instructor, Division of Geographic Medicine Case Western Reserve University, Cleveland, OH
1994-2000 Assistant Professor, Departments of Medicine and Ophthalmology, Case Western Reserve
University, Cleveland, OH
2000-2002 Associate Professor, Departments of Medicine and Ophthalmology, Case Western Reserve
University, Cleveland, OH
2002-2004 Associate Professor, Center for Global Health & Diseases and Department of Ophthalmology
2004-present
Professor, Department of Ophthalmology, Case Western Reserve University, Cleveland.
2004-present Director of Research, Department of Ophthalmology and Visual Sciences, CWRU
Honors
1997
2004
2006 2010
2011
Burroughs Wellcome Foundation New Investigator Award
University of Western Australia Raine Foundation Visiting Professorship
Research to Prevent Blindness Foundation: Senior Investigator Award
Alcon Research Institute award
Page-Reinhart Endowed Professorship, Case Western Reserve University
Peer Review
2008 – 2012 Permanent member, Anterior Eye Diseases study section, National Eye Institute
2008 – present. Ad hoc member, P-30 core grant reviews, National Eye Institute
PHS 398/2590
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Biographical Sketch Format Page
Program Director/Principal Investigator:
Pearlman, Eric
C. Selected peer-reviewed publications (from a total of 98)
1. Carlson, E.C., M. Lin, C-Y. Liu, W-Y. Kao, V. L. Perez and E. Pearlman. 2007. Keratocan And
Lumican Regulate Neutrophil Infiltration And Corneal Clarity In LPS-Induced Keratitis By Direct
Interaction With KC/CXCL1. J. Biol. Chem. 282:35502-9
2. Johnson, AC., X. Li and E. Pearlman. 2008. MyD88 is a negative regulator of TLR3/TRIF -induced
corneal inflammation via c-Jun N-terminal kinase (JNK). J. Biol. Chem. 283:3988-96.
3. Chinnery, H.R., Pearlman, E., and McMenamin, P.G. 2008. Membrane nanotubes in vivo: A novel
feature of MHC class II+cells in the mouse cornea. J. Immunol. Cutting Edge. 180:5779-5783.
4. Tarabishy, A. B., B. Aldabagh, Y. Sun, Y. Imamura, P. K. Mukherjee, J. H. Lass, M. A. Ghannoum,
and E. Pearlman. 2008. MyD88 regulation of Fusarium solani keratitis is dependent on TLR4 and IL1R1, not TLR2. J. Immunol. 181:593-600
5. J. D. Turner, R. S. Langley, K. Johnston, K. Daehnel, L. Ford, B. Wu, M. Graham, F. Sharpley, B.
Slatko, E. Pearlman and M. J. Taylor. 2009. Filarial Wolbachia lipoprotein stimulates innate and
adaptive inflammatory responses through TLR2 and TLR6 and induces disease manifestations of
lymphatic filariasis and river blindness. J. Biol. Chem. 284:22364-78
6. Chinnery, H.R., E. C. Carlson, Y. Sun, M. Lin, S. H. Burnett, V. L. Perez, P. G. McMenamin and E.
Pearlman. 2009. Bone marrow chimeras and c-fms conditional ablation (Mafia) mice reveal an
essential role for resident myeloid cells in LPS/TLR4 -induced corneal inflammation. J. Immunol.
182;2738-2744.
7. Sun, Y and E. Pearlman. 2009. Inhibition of Corneal Inflammation by the TLR4 antagonist Eritoran
tetrasodium (E5564). Invest. Ophth. Vis. Sci. 50:1247–1254.
8. Sun, Y., Y. Imamura, P. Mukherjee, J. Chandra, L. Szczotka-Flynn, M. A. Ghannoum, and E.
Pearlman. 2010. A murine model of contact lens associated Fusarium keratitis. Invest. Ophth. Vis. Sci.,
51.1511-1156.
9. Leal Jr., S. M., S. Hastings, Y-C Hsia, M.A. Ghannoum, M. Momany, and E. Pearlman. 2010. Distinct
Roles for Dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigatus keratitis. PLoS Pathogens
6:1-16.
10. Sun, Y., M. Karmakar, S. Roy, R. T. Ramadan, S. R. Williams, S. Howell, C. L. Shive, Y. Han, C. M.
Stopford, A. Rietsch and E. Pearlman. 2010. Pseudomonas aeruginosa keratitis is regulated by
TLR4/MD-2 and TLR5 on corneal macrophages, and is dependent on TRIF, Mal/TIRAP, MyD88 and IL1R1. J. Immunol. 185:4272-4283.
11. Roy, S., Y. Sun and Pearlman. 2011. IFN- γ - induced MD-2 expression and LPS responsiveness in
corneal epithelial cells is mediated by JAK2 activation and direct binding of STAT1 to the MD-2
promoter. J. Biol. Chem. 286. 23753-62.
12. Karthikeyan, R.S.G., S. M. Leal, Jr., N. V. Prajna, K. Dharmalingam, D. Geiser, E. Pearlman, and P.
Lalitha. 2011. Characterization of the immune response in human corneal tissues infected with the
filamentous fungi Aspergillus and Fusarium. J. Infect Dis. 204(6):942-50.
13. Sun, Y., P. Taylor, A. Rietsch and . 2011. Effectors ExoS and ExoT synergize to promote
Pseudomonas aeruginosa corneal infections. J. Immunol. In press.
14. Chinnery, H. R., S. McLenachan, N. Binz, Y. Sun, J.V. Forrester, M.A. Degli-Esposti, E. Pearlman,
and P.G. McMenamin. 2012. TLR9 Ligand CpG-ODN Applied to the Injured Mouse Cornea Elicits
Retinal Inflammation. Am J. Path. In press.
15. Leal, S. M. Jr. and E. Pearlman. 2012. The Role of Cytokines and Pathogen Recognition Molecules in
Fungal Keratitis – insights from human disease and animal models. Cytokine. In press.
PHS 398/2590 (Rev. 06/09)
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Program Director/Principal Investigator:
Pearlman, Eric
Other Support
Current funding
RO1EY018612 3/1/2008 – 2/28/2013
Title: Pathogenesis of Fungal Keratitis
Role: Primary Investigator (4.8 calendar months effort)
Agency: National Eye Institute
Description: This project examines the role of c-type lectins in the pathogenesis of Fusarium keratitis
Annual Direct costs: $290,000
RO1 EY014362
9/1/2009 – 8/31/2013
Title: Toll Like Receptors in Bacterial Keratitis
Role: Primary Investigator (3.6 calendar months effort)
Agency: National Eye Institute
Description: This project examines the role of toll like receptors in the innate immune response in bacterial
keratitis and in response to bacterial products in the cornea
Annual Direct costs: $250,000
P-30 EY11373 4/1/1998 – 3/30/2012
Title: Visual Sciences Core grant
Role: Primary Investigator (0.6 calendar months effort)
Agency: National Eye Institute
Description: Support for five core modules – Histology and Imaging, Tissue culture and Hybridoma,
Molecular Biology, Proteomics, Specialized Animal Resource
Annual Direct costs: $500,000
R01 EY022052
Title: P. aeruginosa type III secreted effectors in corneal disease
Role: Co-Investigator (1.2 calendar months effort) (PI: Rietsch)
Agency: National Eye Institute
Description: This project examines the mechanism of Type III Secretion System virulence factors in
regulating Pseudomonas aeruginosa keratitis
Annual Direct costs requested: : $250,000
Completed funding
RO1 EY10320 1994 - 2008
Title: Pathogenesis of ocular onchocerciasis (river blindness)
Role: Primary Investigator
Agency: National Eye Institute
Description: This project examined the role of the host response to filarial nematodes and to endosymbiotic
bacteria in onchocerciasis
Annual Direct costs: $250,000
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