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Transcript
GRADUATE SCHOOL OF PHARMACEUTICAL SCIENCES
FACULTY OF PHARMACEUTICAL SCIENCES
CONTENTS
1. HISTORY ................................................................................................................................................................................ 171
2. STUDY PROGRAM FOR UNDERGRADUATES .............................................................................................................. 171
3. COURSES FOR UNDERGRADUATES IN THE PHARMACEUTICAL SCIENCES.................................................... 171
Lectures
1. Required Subjects
2. Elective Required Subjects
3. Elective Subjects
Laboratory Practice
1. Elemental Laboratory Practice
2. Special Laboratory Practice
4. STUDY PROGRAM FOR GRADUATE STUDENTS......................................................................................................... 173
5. FIELDS OF RESEARCH, INSTRUCTION AND STAFF OF THE DEPARTMENTS .................................................... 173
1. DIVISION OF PHYSICAL AND ORGANIC CHEMISTRY .......................................................................................... 173
Department of Bioorganic Medicinal Chemistry
Department of Synthetic Medicinal Chemistry
Department of Organic Chemistry
Department of Pharmacognosy
Department of Analytical Chemistry
Department of Structural Biology
Department of Genomic Drug Discovery
Department of Biosurface Chemistry
Department of Fine Organic Synthesis
2.
DIVISION OF LIFE SCIENCES ..................................................................................................................................... 175
Department of Biological Chemistry
Department of Molecular Microbiology
Department of Molecular Pharmacology
Department of Genetic Biochemistry
Department of Physiological Chemistry
Department of Biofunctional Chemistry
3. DIVISION OF PHARMACY AND BIOMEDICINAL SCIENCES ................................................................................ 176
Department of Drug Delivery Research
Department of Pharmacology
Department of Clinical Pharmacy and Education
Deprtment of Patho-Functional Bioanalysis
Department of Biopharmaceutics and Drug Metabolism
Department of Clinical Pharmacy
4. DIVISION OF BIOINFORMATICS AND CHEMICAL GENOMICS............................................................................ 178
Department of Pharmacogenomics
Department of Chemogenomics
Department of Systems Biology
Department of System Chemotherapy
Department of Integrated Genomics
Department of Computational Genomics
5.
CONTRIBUTED CHAIRS .............................................................................................................................................. 180
Department of Neuroscience for Drug Discovery
Department of Nanobio Drug Discovery
Department of Systems Bioscience for Drug Discovery
6. EDUCATION AND RESEARCH FACILITIES .............................................................................................................. 181
Center for Integrative Education of Pharmacy Frontier
Experimental Station for Medical Plant Research
Center for Organic Elemental Microanalysis
Support Program for Improving Graduate School Education
Service Innovation Program
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GRADUATE SCHOOL OF PHARMACEUTICAL SCIENCES
FACULTY OF PHARMACEUTICAL SCIENCES
Dean: ITOH, Nobuyuki, D.Pharm.Sci.
46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501
Tel. +81-75-753-4510
Fax. +81-75-753-4502
http://www.pharm.kyoto-u.ac.jp/
1. HISTORY
The Faculty of Pharmaceutical Sciences originated in the
Division of Pharmacy which was established in 1939 in the
Faculty of Medicine. The Division of Pharmacy was expanded gradually and separated in 1960 from the Faculty of
Medicine to establish the new Faculty of Pharmaceutical Sciences, with seven departments. Subsequently, the Faculty has
been expanded from time to time, and is now comprised of
twenty-seven Departments and three affiliated Institutions
(the Center for Organic Elemental Microanalysis, Center for
Integrative Education of Pharmacy Frontier and the Experimental Station for Medical Plant Research).
A comprehensive reorganization of the Faculty of Pharmaceutical Sciences and the Graduate School of Pharmaceutical
Sciences was completed in 1997. This reorganization is
aimed to cope with the need for advanced research and education in pharmaceutical science and to emphasize both education and research in the Graduate School Program. The Graduate School is presently composed of four major fields of
pharmaceutical sciences: 1. Division of Physical and Organic
Chemistry; 2. Division of Life Sciences; 3. Division of Pharmacy and Biomedicinal Sciences , 4. Division of Bioinformatics and Chemical Genomics which has been established in
2007. The teaching and research activities of the Faculty
and the Graduate School range over all the main fields of
pharmaceutical sciences. The academic staff of the Graduate
School is composed of sixty-three highly experienced professional scientists, including twenty Professors, twenty-five
Associate Professors and Lecturers, and fourteen Assistant
Professors. All members of the Graduate Program are now
jointly appointed as the teaching staff for the undergraduate
courses.
The Faculty and the Graduate School also have a division
for administrative tasks. The Graduate School has the following facilities: library, laboratories for NMR, MS, ESR, CD,
Laser-Raman, X-ray, electron-microscope, radioisotope, biotechnology, molecular biology and cell biology, a greenhouse,
and botanical garden.
2. STUDY PROGRAM FOR
UNDERGRADUATES
The Faculty offers instruction for undergraduate students of
the Division of Pharmacy and Division of Sciences for Drug
Discovery. Thirty and fifty undergraduate students are admitted for these divisions, respectively, each year. To qualify for admission, students must have completed 12 years of
schooling, and pass the entrance examination, which is usually given towards the end of February or at the beginning of
March. Foreign students must take a General Examination
for Overseas Students, and also the Faculty's special entrance
examination for overseas students which is usually given at
the end of February. See the section entitled "Academic
Programs" in Part 1 of the Bulletin for general regulations and
rules concerning admission.
To complete the undergraduate course and to receive the
bachelor's degree, students are required to study for at least
six years in the Division of Pharmacy or four years in the Division of Sciences for Drug Discovery. The Bachelor of
Pharmacy and Bachelor of Sciences for Drug Discovery degrees are conferred upon those students who have satisfied all
the credits requirements and have also completed the Graduation Research Project (Specialized Laboratory Work), under
the supervision of an academic member of the Graduate
School of Pharmaceutical Sciences corresponding to the student's specialization. For further details, consult the Kyoto
University Regulations, and the Rules of the Faculty of Pharmaceutical Sciences.
The minimum numbers of courses and credits required for
graduation are as follows:
Courses in Liberal Arts and Sciences: 62 credits minimum,
including
1. Humanities and Social Sciences: 20 credits in 5 courses
(elective subjects)
2. Natural Sciences: 26 credits in 15 courses (elective and
specified subjects)
3. Foreign Languages: 2 languages; 8 credits in English and 4
credits in one other selected from German, French, Chinese,
Russian, Italian, Korean, and Spanish.
Courses in the Division of Pharmacy: 138 credits minimum,
including
1. Lecture subjects: 82 credits
2. Laboratory practice: 16 credits
3. Clinical practice: 22 credits
4. Specialized laboratory work: 12 credits
Courses in the Division of Sciences for Drug Discovery: 80
credits minimum, including
1. Lecture subjects: 56 credits
2. Laboratory practice: 18 credits
3. Specialized laboratory work: 6 credits
3. COURSES FOR UNDERGRADUATES IN
THE PHARMACEUTICAL SCIENCES
Classification of Subjects
Lectures
1. Required Subjects (2 credits each)
Course (Lecturer)
Introduction to Pharmaceutical Sciences and Ethics by staff
Fundamental Biology for Pharmaceutical Sciences by Takeshima
Fundamental Physical Chemistry for Pharmaceutical Sciences
by Handa
Basic Organic Chemistry A by Ohno
Basic Organic Chemistry B by Takasu
Scientific English by Foong
172
Organic Chemistry 1(Synthetic Organic Chemistry) by Kawabata
Organic Chemistry 2(Bioorganic Chemistry) by Takemoto
Organic Chemistry 3(Medicinal Chemistry) by Fujii, Kakeya,
Futaki, Hattori
Organic Chemistry 4(Fine Synthetic Chemistry) by Tomioka,
Yamada
Pharmacognosy 2(Pharmaceutical Resources) by Kakeya, Hattori
Physical Chemistry 1(Quantum Chemistry) by Kitaura
Physical Chemistry 2(Electro- and Interface- Chemistry) by
Handa
Analytical Chemistry 1(Basic Analytical Chemistry) by Matsuzaki
Analytical Chemistry 2(Radiochemistry) by Saji
Analytical Chemistry 3(Spectroscopy) by Hoshino,Nakano
Biological Chemistry 1(Biomolecules) by Yamazaki
Biological Chemistry 2(Energy Metabolism) by Nakayama
Biological Chemistry 3(Molecular Biology) by Itoh
Microbiology 1(Bacteriorogy) by Tochikura
Pharmaceutical Health Science 1(Health Chemistry) by Nakayama
Physiology 2(Molecular Physiology) by Kaneko
Physiology 3(Pathophysiology for drug discovery and personalized medicine) by Tsujimoto,Okamura
Pharmacology 1(Overview and Peripheral Nervous System
Pharmacology) by Akaike,Kume
Pharmaceutics 1(Liquid Formulations) by Hashida,Yamashita
Medicinal Pharmacy 3(Biopharmaceutics) by Takakura,Yamaoka
2. Elective Required Subjects [2 credits each]
Course (Lecturer)
Pharmaceutical Botany by Ito
Information Processing Basics by Nakatsu,Hirasawa
3. Elective Subjects (2 credits each)
Course (Lecturer)
Organic Chemistry 5(Biofunctional Chemistry) by Futaki
Pharmacognogy 1(Natural Product Chemistry) by Tomioka,Yamada
Pharmacognosy 3(Applied Pharmacognosy) by Ito
Medicinal Chemistry Discovery and Development of New
Drugs by Fujii, Kitaura, Sugimoto
Organic Chemistry Exercise by staff
Physical Chemistry 3(Structural Chemistry) by Kato
Physical Chemistry 4(Biophysical Chemistry) by Matsuzaki,Hoshino
Analytical Chemistry 4(Clinical Chemistry) by Saji,Ono
Medicinal Physical Chemistry Exercise 1 by staff
Medicinal Physical Chemistry Exercise 2 by staff
Biological Chemistry 4(Applied Molecular Biology) by Itoh
Biological Chemistry 5(Cell Biology) by Kozutsumi
Biological Chemistry 6(Physiological Chemistry) by Negishi
Biological Chemistry 7(Immunobiology) by Sugimoto
Microbiology 2(Virology) by Watanabe
Pharmaceutical Health Science 2(Public Health) by Nakayama
Physiology 1(Anatomical Physiology) by Akaike,Kaneko
Physiology 4(Genomic medicine) by Tsujimoto,Okamura
Pharmacology 2(Cardiovascular Pharmacology) by Nakagawa
Pharmacology 3(Central Nervous System Pharmacology) by
Akaike,Kume
Therapeutic Pharmacology 1 by Kaneko,Nakagawa
Therapeutic Pharmacology 2 by Akaike,Kume
Pharmaceutics 2(Solid formulations) by Hashida,Nishikawa
Clinical Pharmacy 1 by Yano, Katsura
Clinical Pharmacy 2 by Yano
Pharmacopoeia ; Pharmaceutical Laws by Hashida,Yamashita
Statistical Basis for Biosciences by Yano
Introduction to Bioinformatics by Okuno,Kaneko
Pharmaceutical R&D by Sakaeda,Okuno
Laboratory Practice
1. Elemental Laboratory Practice (required subject, a total
of 16 credits)
Course
Part I: Advanced Laboratory Practice in Pharmaceutical
Sciences I (4 credits)
Part II: Advanced Laboratory Practice in Pharmaceutical
Sciences II (4 credits)
Part III: Advanced Laboratory Practice in Pharmaceutical
Sciences III (4 credits)
Part IV: Advanced Laboratory Practice in Pharmaceutical
Sciences IV (4 credits)
2. Special Clinical Practice (required subject, a total of 22
credits for Division of Pharmacy)
Course
Pre-Training for Clinical Clerkship
Clinical Clerkship in Hospital Pharmacy
Clinical Clerkship in Community Pharmacy
3. Special Laboratory Practice (Graduation Research Project ) (elective subject, 6 or 12 credits each)
Course (Lecturer)
Bioorganic Medicinal Chemistry by Fujii,Ohno
Synthetic Medicinal Chemistry by Tomioka, Yamada
Organic Chemistry by Takemoto,Takasu
Pharmacognosy by Ito
Analytical Chemistry by Matsuzaki, Hoshino
Structural Biology by Kato,Nakatsu
Biosurface Chemistry by Handa,Nakano
Biological Chemistry by Takeshima,Yamazaki
Molecular Microbiology by Watanabe
Molecular Pharmacology by Kaneko, Nakagawa
Genetic Biochemistry by Itoh
Physiological Chemistry by Nakayama, Sugimoto
Drug Delivery Research by Hashida, Yamashita
Pharmacology by Akaike,Kume,
Patho-Functional Bioanalysis by Saji,Ono
Biopharmaceutics and Drug Metabolism by
Takakura, Yamaoka, Nishikawa
Phamacogenomics by Tsujimoto,Hirasawa
Chemogenomics by Fujii,
Systems Biology by Okamura
System Chemotherapy and Molecular Sciences by Kakeya,
Hattori
System Chemotherapy (Computational Drug Design) bu KitauraFine Organic Synthesis by Kawabata
Biofunctional Chemistry by Futaki
Clinical Pharmacy by Inui
Integrated Genomics by Kanehisa
Computational Genomics by Mamitsuka
Experimental Station for Medicinal Plants by Staff
Pharmaceutical Sciences 173
4. STUDY PROGRAM FOR GRADUATE
STUDENTS
The comprehensive structural reorganization of the entire
Graduate School of Pharmaceutical Sciences was completed
in 1997. The Graduate School, which is known as the
Graduate School of Pharmaceutical Sciences, offers courses
for advanced instruction and opportunity for research; the
staff includes all the members of the Graduate School, the
staff of the four Departments of the Institute for Chemical
Research, the staff of the Pharmaceutical Division of the
University Hospital, and of the Institute for Virus Research.
The Graduate School provides four courses: 1. Physical and
Organic Chemistry, 2. Life Sciences, 3. Pharmacy and Biomedicinal Sciences, and 4. Bioinformatics and Chemical Genomics (from 1st April, 2007). A limited number (temporally
maximum five) of Master course students can be admitted to
the advanced clinical pharmacy course (beginning from 2001).
A total of eighty graduate students are admitted each year into
the Graduate School. To qualify for admission, applicants
must normally have completed 4 years of education at the
undergraduate school and also pass the entrance examination,
usually given in August. Overseas students wishing to take the
Graduate course must pass the same entrance examination as
that given to Japanese students, or the Faculty's special entrance examination for overseas students usually given in December or January.
The Graduate School offers the Master's and Doctoral degrees. To receive the Master's degree, students are required to
study for at least two years, and to earn a minimum of 30 credits in the graduate courses, including at least 14 credits in
required subjects and at least 16 credits in elective subjects.
The students who were admitted to advanced clinical pharmacy course and qualified as a licensed pharmacist must have
6 months practice at University hospital.
Students must
submit a Master's thesis and pass the final examinations, including an oral presentation. To receive the Doctoral degree,
students must normally conduct research work for at least
three years in the specialized field under the supervisor's
guidance, and to earn a minimum of 8 credits in the graduate
courses, submit a Doctoral thesis and pass the final examinations, including an oral presentation.
5. FIELDS OF RESEARCH, INSTRUCTION
AND STAFF OF THE DEPARTMENTS
1. DIVISION OF PHYSICAL AND ORGANIC CHEMISTRY
Department of Bioorganic Medicinal Chemistry
Professor
FUJII, Nobutaka, D.Pharm.Sci. (Kyoto Univ.)
Associate Professor
OHNO, Hiroaki, D.Pharm.Sci. (Kyoto Univ.)
Assistant Professor
OISHI, Shinya, D.Pharm.Sci. (Kyoto Univ.)
Outline of Teaching Activities
The Laboratory is responsible for undergraduate instruction
in organic chemistry (chemical bonding, stereochemistry, and
modern synthesis) and medicinal chemistry (design and synthesis). The Department provides graduate students with
seminars, which review and discuss recent important medici-
nal and synthetic chemical literature. Laboratory practice in
synthetic chemistry, heteroaromatic chemistry and medicinal
chemistry is also provided.
Outline of Research Activities
The main research fields are as follows:
1. Development of efficient strategy for synthesis of heterocycles directed toward construction of novel drug templates
2. Synthetic studies on direct construction of natural product
type drug like templates
3. Synthetic studies on peptides, including antimicrobial and
anti-viral peptides
4. Synthetic studies on peptidomimetics, including conformationally constrained pseudopeptides
Department of Synthetic Medicinal Chemistry
http://www.pharm.kyoto-u.ac.jp/tomioka/index.html
Professor
TOMIOKA, Kiyoshi, D.Pharm.Sci. (Univ. of Tokyo)
Associate Professor
YAMADA, Ken-ich, D.Pharm.Sci. (Univ.of Tokyo)
Assistant Professor
YAMAMOTO, Yasutomo, M.Pharm.Sci. (Kyoto Univ.)
Outline of Teaching Activities
The Department is responsible for general instruction in
synthetic organic chemistry (molecular structure, stereochemistry,
synthesis, mechanism, design, total synthesis and biological
activity-structure relationships) for undergraduate students,
and for laboratory practice on advanced high grade synthetic
organic chemistry.
Outline of Research Activities
1. Synthetic methodology
2. Asymmetric reaction
3. Synthesis and chemistry of biologically active molecule
4. Molecular basis for bioresponse molecule
5. Molecular architecture
Department of Organic Chemistry
Professor
TAKEMOTO, Yoshiji, D.Pharm.Sci. (Osaka Univ.)
Associate Professor
TAKASU, Kiyosei, D.Pharm.Sci. (Kyoto Univ.)
Outline of Teaching Activities
The Laboratory is responsible for instruction in organic
chemistry covering the basic concepts of organic reactions,
stereochemistry, synthesis, and spectroscopic methods for
undergraduate students. The Department provides graduate
students with seminars which review and discuss recent important organic and organometallic reactions. Laboratory
practice in advanced synthetic and organometallic chemistry
is also provided.
Outline of Research Activities
1. Development of new enantio- and stereoselective synthetic
methods involving transition-metal catalysts
2. Development of environmentally friendly synthetic methods for process chemistry
174
3. Total synthesis of biologically important synthetic and natural products
4. Synthetic studies on multi-functional heterocyclic compounds and their use as drug-templates
5. Development of new biological and medicinal probes based
on chemical biology
Department of Pharmacognosy
Associate Professor
ITO, Michiho, D.Pharm.Sci. (Kyoto Univ.)
Outline of Teaching Activities
The Department is responsible for undergraduate instruction
in pharmacognosy covering characteristics, production, biological activity and evaluation of medicinal plants and natural
medicines. For graduate students, the Department provides
seminars, reviews and discussion of recent pharmacognostical
and botanical literature.
Outline of Research Activities
Main research fields are as follows:
1. Genetic regulation of secondary metabolism and production
of medicinal compounds in plants
2. Molecular basis of secondary metabolism in medicinal
plants
3. Phytochemical and pharmacological analyses of traditional
medicines
4. Field research of important medicinal resources and traditional medicines in Asian countries
Department of Analytical Chemistry
http://www.pharm.kyoto-u.ac.jp/yakkai/
Professor
MATSUZAKI, Katsumi, D.Pharm.Sci. (Kyoto Univ.)
Associate Professor
HOSHINO, Masaru, D.Sci. (Osaka Univ.)
Assistant Professor
YANO, Yoshiaki, D.Pharm.Sci. (Kyoto Univ.)
Outline of Teaching Activities
This Department is responsible for general undergraduate
instruction in analytical chemistry and in biophysical chemistry
necessary for the understanding of the structure formation and
function of biomembranes and proteins. The Department
provides graduate students with seminars, which introduce the
latest advances in membrane and protein biophysics.
Outline of Research Activities
The main research fields are as follows:
1. Elucidation of action mechanisms of antimicrobial peptides
and the development of potent antibiotic peptides
2. Thermodynamics of transmembrane helix-lipid interactions
3. Interactions of amyloid peptides with glycolipids
4. Regulation of G-protein coupled receptors
5. Structure determination of proteins by NMR
Department of Structural Biology
Professor
KATO, Hiroaki, D.Agr. (Kyoto Univ.)
Associate Professor
NAKATSU, Toru, D.Agr. (Kyoto Univ.)
Assistant Professor
YAMAGUCHI, Tomohiro, D.Sci. (Kyoto Univ.)
Outline of Teaching Activities
This Department is responsible for general undergraduate
instruction in structural sciences including quantum chemistry,
physical chemistry of materials, and X-ray crystallography as
well as their application to understanding of biological function.
For graduate students, the department provides classes in advanced structural sciences, seminars, reviews and discussions
on recent publications in structural biology.
Outline of Research Activities
The emphasis of the research is on understanding the
structure and function of macromolecules through structure
determination by X-ray crystallography as well as a wide
range of correlative biophysical and biochemical studies of
function. The main research fields are as follows:
1. Structural-basis for action of transporters and channels
2. Structural and functional studies on translocation machinery
of membrane proteins to organelles
3. Structural origin of catalytic power of enzymes
4. Structural biology of circadian clock machinery
Department of Genomic Drug Discovery
Outline of Teaching Activities
The Department is responsible for undergraduate instruction in Drug Discovery Process based on Genome Science.
The Department provides graduate students with seminars,
which review and discuss recent important literature in molecular biology and genome science.
Outline of Research Activities
The main research fields are as follows:
1. Discovery of novel drug target and its validation by integrative genome science
2. Functional genomic study using transgenic/knockout
animals
Department of Biosurface Chemistry
Professor
HANDA, Tetsurou, D.Pharm. Sci. (Kyoto Univ.)
Associate Professor
NAKANO, Minoru, D.Eng. (Kyoto Univ.)
Outline of Teaching Activities
The department is responsible for undergraduate instruction
in thermodynamics, solution chemistry, electrochemistry,
phase equilibrium, chemical reaction, and colloid and surface
chemistry. There is a seminar which reviews recent progress
in biosurface and biophysical chemistry. Laboratory practice
on advanced biocolloid and biosurface chemistry is also provided.
Outline of Research Activities
1. Biophysical chemistry on the plasma apolipoprotein
recognition of lipid surface in lipoprotein metabolism
2. Biocolloid and biosurface chemistry on assembling
Pharmaceutical Sciences 175
phospholipids, sphingolipids, glycolipids and glycerides
into monolayers (emulsions), bilayers (vesicles) and nonbilayer structures (cubosomes, hexosomes)
3. Biophysical aspects of lipid risk factors for atherosclerosis
4. A drug design of inhibitors for protein tyrosine kinases
Department of Fine Organic Synthesis
Professor
KAWABATA, Takeo, D.Pharm. Sci. (Kyoto Univ.)
Associate Professor
FURUTA,Takumi, D.Pharm. Sci. (Kyoto Univ.)
Assistant Professor
YOSHIMURA, Tomoyuki, D.Pharm. Sci. (Tokushima Univ.)
Outline of Teaching Activities
This Department is responsible for instruction of basic
techniques in synthetic organic chemistry and molecular recognition. These include separation, purification, and characterization of organic molecules and instrumental analyses
such as NMR, IR, UV, MS, CD and so on. Recent papers
dealing with unit reactions, asymmetric syntheses, molecular
recognition, and total synthesis of biologically active natural
products are the main topics of discussion in the group seminar.
Outline of Research Activities
Research in this laboratory focuses on molecular chirality.
Programs are active in the areas of asymmetric synthesis
based on“memory of chirality”, organocatalysis for selective
reactions, synthesis of novel nitrogen heterocycles, total synthesis of biologically active products, visualization of molecular information by functional phenolphthaleins, and the
structural and functional investigation of D,L-oligoesters,
D,L-oligopeptides, and homochiral oligonaphthalenes.
2. DIVISION OF LIFE SCIENCES
Department of Biological Chemistry
http://bio.pharm.kyoto-u.ac.jp/biochem/index.html
Professor
TAKESHIMA, Hiroshi, D.Pharm.Sci. (Kyoto Univ.)
Associate Professor
YAMAZAKI, Tetsuo, D.Med. (Chiba Univ.)
Outline of Teaching Activities
This Department is responsible for instruction in biochemistry, molecular biology, cell biology and immunology for
undergraduate and graduate students. The Department provides graduate students with seminars, which review and discuss recent advances in biochemistry and molecular biology.
Laboratory practice in advanced experimental techniques of
molecular biology and cellular physiology is also provided.
Outline of Research Activities
The current research activities are as follows:
1. Structure and function of intracellular Ca2+ stores
2. Mechanism of cellular Ca2+ signaling
3. Molecular determinants of muscle membrane structures
4. Biological roles of sugar chains
Department of Molecular Microbiology
Associate Professor
WATANABE, Yoshihiko, Ph.D. (D.Med.Sc. Kyoto Univ.)
Teaching Activities
Two subjects, Microbiology 1and 2, are covered in lectures
for 3rd -year undergraduate students , which are composed
of lectures focusing respectively on bacteria and viruses
(morphology, physiology, and molecular biology) to provide
fundamental knowledge and understanding of microbes that
cause infectious diseases, including pathogenesis, host defense mechanisms, prophylaxis, and chemotherapy. The
Laboratory Practice of Microbiology assigned to 3rd-year
undergraduate students is a training course on fundamental
techniques required for research in microbiology. Special
Laboratory Practice in Molecular Microbiology assigned to
4th-year students includes research and seminars concerning
molecular and cellular biology and immunology of host defense mechanisms against animal infectious viruses and tumors.
Research Activities
The research interests of the department include basic molecular and cellular biology, virology, immunology, and oncology. The current subjects chosen for study are as follows:
1. Molecular mechanisms of interferon production in various
phases of host defense
2. Cellular responses to interferon action in immune reaction,
tumor development and viral infection
3. Basic therapeutic studies for interferon gene therapy
against infectious diseases and cancers
Department of Molecular Pharmacology
Professor
KANEKO, Shuji, D.Pharm.Sci. (Kyoto Univ.)
Associate Professor
NAKAGAWA, Takayuki, D.Pharm.Sci. (Kyoto Univ.)
Assistant Professor
SHIRAKAWA, Hisashi, D.Pharm.Sci. (Kyoto Univ.)
Outline of Teaching Activities
The department provides instructuon and techniques in
general physiology, anatomical and functional bases of the
living body, neuropharmacology and relevant subfields of
pharmacology through lectures, laboratory practice and seminars for both undergraduate and graduate students. We also
provide a unique ’Life Science Dictionary’ for students and
researchers on the World Wide Web
http://lsd.pharm.kyoto-u.ac.jp
Outline of Research Activities
The main research fields are as follows:
1. New drug development targeted for various membranetransport proteins on the basis of genomic information
2. Development of new screening strategies and probes for
ion channel study
3. Physiological and pathological roles of membrane-transport
proteins expressed in neurons and glia
4. Neuropharmacology of analgesics and molecular biology of
pain
176
5. Molecular mechanisms of drug tolerance and dependence
prostaglandin receptors
Department of Genetic Biochemistry
Professor
ITOH, Nobuyuki, D.Pharm.Sci. (Kyoto Univ.)
Department of Biofunctional Chemistry
Professor
FUTAKI, Shiroh, D.Pharm.Sci. (Kyoto Univ.)
Lecturer
MIYAKE, Ayumi, D.Pharm.Sci.(Kyoto Univ.)
Assistant Professors
IMANISHI, Miki, D.Pharm.Sci. (Kyoto Univ.)
Assistant Professor
KONISHI, Morichika, D.Pharm.Sci. (Kyoto Univ.)
NAKASE, Ikuhiko, D.Pharm.Sci. (Kyoto Univ.)
Outline of Teaching Activities
The Department is responsible for undergraduate instruction
in biochemistry (structure and function of nucleic acid, mechanism of protein synthesis, and mechanism and regulation
of gene expression), and in applied molecular genetics (recombinant DNA technology, biotechnology and molecular biology of diseases). The graduate seminar reviews and discusses recent literature on biochemistry, molecular biology
and biotechnology.
Outline of Research Activities
The main research fields are as follows:
1. Identification of genes for novel intercellular signaling molecules (growth factors, differentiation factors and hormones)
2. Structure and function of signaling molecules, and regulation
of their gene expression
3. Roles of signaling molecules in metabolic regulation
4. Roles of signaling molecules in vertebrate development
Department of Physiological Chemistry
Professor
NAKAYAMA, Kazuhisa, Ph.D.(Kyoto Univ.)
Outline of Teaching Activities
The Department is responsible for undergraduate instruction
in bioorganic, bioinorganic, and biomedical chemistries, and
also provides graduate students with seminars which review
and discuss recent biochemical and biomedical literature. In
addition, the Department provides laboratory practice in biochemical, biophysical, and molecular biological chemistries.
Outline of Research Activities
The ultimate goal of our research is the regulation of cellular functions by designed peptides and proteins. Current
projects include “Development of membrane permeable peptide vectors”, “Creation of novel zinc finger peptides with desired DNA binding characteristics”, and “Design of functional
peptides responsive to external signals”.
This Department, which belongs to the Institute for Chemical
Research of Kyoto University, is affiliated with the Graduate
School of Pharmaceutical Sciences.
3. DIVISION OF PHARMACY AND BIOMEDICINAL
SCIENCES
Associate Professor
SUGIMOTO, Yukihiko, D.Pharm.Sci. (Kyoto Univ.)
Department of Drug Delivery Research
http://dds.pharm.kyoto-u.ac.jp/Dds-Home/index.htm
Professor
HASHIDA, Mitsuru, D.Pharm.Sci. (Kyoto Univ.)
Assistant Professor
SHIN, Hye-Won, D. Phil. (Univ.Tsukuba)
Associate Professor
YAMASHITA, Fumiyoshi, D.Pharm.Sci. (Kyoto Univ.)
Outline of Teaching Activities
The laboratory is responsible for general undergraduate instruction in physiological chemistry (generation and storage
of metabolic energy, carbohydrate metabolism and fatty acid
metabolism, hormonal regulation of metabolism), and in environmental health and hygiene chemistry. The department
provides graduate students with seminars, which review and
discuss recent important biochemical and physiological literature, focused on cell biology, membrane traffic, signal
transduction, and inflammation. Laboratory practice in cell
biology, molecular biology and physiology is also provided.
Outline of Research Activities
The main research fields are as follows:
1. Molecular mechanisms underlying membrane trafficking
and localization of proteins around the Golgi apparatus
2. Relationship between membrane traffic and other cellular
functions, including protein degradation and cell division
3. Molecular biological studies on the biology of mast cells
and other inflammation-participating cells
4. Molecular biological studies on structure and function of
Assistant Professor
KAWAKAMI, Shigeru, D.Pharm.Sci. (Kyoto Univ.)
Outline of Teaching Activities
Lectures for undergraduate students deal with the general
principles of the formulation, evaluation, and technology of
various dosage forms and introduction to biopharmaceutics
and pharmacokinetics. Advanced biopharmaceutical experimentation and theories concerning the mechanism of drug
disposition in the body are provided for graduate students,
with particular emphasis upon the control of the in vivo fate
of drugs and delivery systems. In seminars students participate
in discussion and review of literature in the targeting and controlled release of drugs involving peptides, proteins, and
genes.
Outline of Research Activities
The main emphasis of the Department is on the development
of methods of controlled drug delivery such as:
1. Hepatic targeting employing receptor-mediated endocytosis
2. Rational design of macromolecular and particulate carriers
Pharmaceutical Sciences 177
3. In vivo disposition control and targeting of proteins by
chemical modification
4. Cell specific delivery of genes
5. In silico prediction of mucosal and skin absorption of drugs
Department of Pharmacology
Professor
AKAIKE, Akinori, D.Pharm.Sci. (Kyoto Univ.)
Associate Professor
KUME, Toshiaki, D.Pharm.Sci. (Kyoto Univ.)
Assistant Professor
IZUMI, Yasuhiko, D.Pharm.Sci. (Kyoto Univ.)
Outline of Teaching Activities
The laboratory is responsible for undergraduate instruction
in general physiology and pharmacology including general
principles of drug action, receptors and ion channels, pharmacological actions of drugs acting on the peripheral and
central nervous systems. The department provides graduate
students with advanced lectures on mechanisms of actions of
drugs and laboratory practice in advanced methods in pharmacology, including primary culture of neurons, purification
of biologically active substances and behavioral pharmacology.
In seminars, reviews and discussions of recent important
pharmacological literature are provided.
Outline of Research Activities
The main research fields are as follows:
1. Elucidation of mechanism of neuroprotective action of
serofendic acid, a novel low molecular weight substance
derived from fetal calf serum
2. Mechanisms of neuroprotective effects of nicotinic acetylcholine, neuropeptides, steroids and vitamins
3. Analysis of the role of nitric oxide and reactive oxygen
species in the neurodegeneration of the brain and retina
4. Basic research for development of novel drugs on acute and
chronic neurodegenerative disorders
Department of Clinical Pharmacy and Education
Associate Professor
YANO, Ikuko, D.Pharm.Sci. (Kyoto Univ.)
Outline of Teaching Activities
The Department is responsible for general instruction and
practice in clinical pharmacy and pharmacist activities for
undergraduate and graduated students, and for laboratory
practice on pharmacokinetics / pharmacodynamics.
Outline of Research Activities
1.Pharmacokinetics and pharmacodynamics in disease states
2.Therapeutic drug monitoring and individualized pharmacotherapy
Deprtment of Patho-Functional Bioanalysis
Professor
SAJI, Hideo, D.Pharm.Sci. (Kyoto Univ.)
Associate Professor
ONO, Masahiro, D.Pharm.Sci. (Kyoto Univ.)
Assistant Professors
TEMMA, Takashi, M.Pharm.Sci. (Kyoto Univ)
KIMURA, Hiroyuki, D.Pharm.Sci. (Kyoto Univ.)
Outline of Teaching Activities
Responsible for the general undergraduate student instruction
in radiochemistry (physical and chemical basis, principles on
the production of radionuclides, detection of radioactivity,
synthesis of labeled compounds and their application in life
science), radiopharmaceutical chemistry (basis on diagnostic
and therapeutic radiopharmaceutical drug design and synthesis), radiopharmacokinetic and radiopharmacodynamic aspects of localization mechanism and bioanalytical chemistry.
Some basic concepts in radiation biology along with procedures for the safe handling of radioactive material are offered.
Quantitative analysis of bioactive materials with
non-radioactive methods is also offered, along with the application of radiolabeled compounds in nuclear medicine, a
bioimaging field and in drug development research. Also, inroads made by other imaging technologies, such as conventional X-ray computed tomography (CT), ultrasound imaging
(US) and nuclear magnetic resonance imaging (MRI), and basis on bioimaging assisted by the use of contrast agents are
considered. For the graduate students, seminars are held for
review and discussion of recent literature.
Outline of Research Activities
The department is currently focussing on the development
of newly designed and molecular imaging probes radiopharmaceuticals for biology, in vivo biochemistry, medical diagnosis and therapy, using gamma, beta and positron emitting
radionuclides. Moreover, the use of radiolabeled compounds
for research in drug manufacturing and in vivo pharmacological or toxicological interaction of drugs, constitute another
field of interest. The main nuclear bio-imaging technologies
employed in the diagnosis of patients are the positron emission tomography (PET) and the single photon emission computed tomography (SPECT). In the area of therapeutical drugs,
protein or peptide based radiopharmaceuticals, bone cells
sensitive drugs are being studied for radiotherapy and pain
palliation.
Main areas of research:
1. Drug development for the bioimaging of brain neurotransmitters, neuroreceptor functions and enzymatic activity in
physiological condition and diseases. Pharmacokinetic and
pharmacodynamic evaluation of neuroleptic drug action in
living animal models under diverse pharmacological medication
2. Drug development for tumor diagnosis and therapy based
on radiometal labeled antitumor antibodies, peptides and on
biologically active radiometal complexes;moreover, studies
on the use of radiotherapeutic drugs in cancer and bone
pain palliation
3. Drug development for the diagnosis of energy metabolism
related disorders and hypoxic tissue related disorders (heart,
brain ischemia)
4. Development of methodologies for the in vivo imaging for
specific gene expression (molecular imaging)
5. Development of in vitro and in vivo dynamic methodologies
for the pharmacokinetic and pharmacodynamic analysis of
drug action
6. Studies on metals and metal-complexes in biological systems
and their applicability as drugs for diagnostic or therapeutic
178
use
Department of Biopharmaceutics and Drug Metabolism
http://www.pharm.kyoto-u.ac.jp/byoyaku/English/index.html
Professor
TAKAKURA, Yoshinobu, D.Pharm Sci. (Kyoto Univ.)
Associate Professors
YAMAOKA, Kiyoshi, D.Pharm Sci. (Kyoto Univ.)
NISHIKAWA, Makiya, D.Pharm.Sci. (Kyoto Univ.)
Outline of Teaching Activities
Lectures on basic biopharmaceutics and pharmacokinetics
are provided by the Department for undergraduate students.
Advanced in vivo and in vitro experimental methods and
techniques and theories for mechanistic studies on drug
disposition in the body are provided for graduate students.
The Department also provides students with seminars, in
which recent topics and advances in biopharmaceutical studies are reviewed and discussed based on the literature with
particular emphasis on drug disposition.
Outline of Research Activities
The main research subjects in the Department are as
follows:
1. Design and tissue distribution control of nucleic acid drugs
for optimized gene therapy and DNA vaccination
2. Establishment of therapeutic strategies based on RNA interference using siRNA and shRNA-expressing vectors
3. Manipulation of immunological consequences by control of
in vivo and intracellular pharmacokinetics of DNA vaccine
and antigen peptide
4. Analysis of nucleic acid-mediated immune activation and
its therapeutic application based on DNA assembly
5. Statistical pharmacokinetic analysis of tissue distribution of
therapeutic macromolecular compounds
Department of Clinical Pharmacy
Professor
INUI, Ken-ichi, D.Pharm.Sci. (Kyoto Univ.)
Associate Professor
KATSURA, Toshiya, D.Pharm.Sci. (Kyoto Univ.)
Lecturer
MASUDA, Satohiro, D.Pharm.Sci. (Kyoto Univ.)
Assistant Professors
MOTOHASHI, Hideyuki, D.Pharm.Sci. (Kyoto Univ.)
FUKUDO, Masahide, D.Pharm.Sci. (Kyoto Univ.)
YONEZAWA, Atsushi, D.Pharm.Sci. (Kyoto Univ.)
Outline of Teaching Activities:
The department is responsible for instruction of undergraduate and graduate students in the Schools of Medicine
and Pharmaceutical Sciences, as well as clinical training of
pharmacy residents, in efficacy and safety of drug therapy.
Outline of Research Activities:
1. Functional and molecular characterization of drug trans-
porters and its clinical application
2. Pathophysiological roles of drug transporters
3. Mechanisms of drug interaction
4. Pharmacogenomics and personalized medicine
This Department, which belongs to Kyoto University
Hospital, is affiliated with the Graduate School of Pharmaceutical Sciences
4. DIVISION OF BIOINFORMATICS AND
CHEMICAL GENOMICS
Department of Pharmacogenomics
Professor
TSUJIMOTO, Gozoh, M.D., Ph.D. (Shinshu Univ.)
Associate Professor
HIRASAWA, Akira, D.Med.Sci. (Yamanashi Univ.)
Assistant Professor
TERASAWA,Kazuya, D.Sci. (Kyoto Univ.)
KIMURA,Ikuo, D.Pharm.Sci. (Kyoto Univ.)
Outline of Teaching Activities
The Department is responsible for undergraduate instruction in Pharmacogenomics based on Genome Science (Bioinformatics, Pharmacogenomics, Genome Technology, Transcriptome Scanning, Proteomics). The Department provides
graduate students with seminars, which review and discuss
recent important literature in molecular biology, genome science, bio-informatics, medicine and physiology.
Outline of Research Activities
The main research fields are as follows:
1. Personalized medicine (pharmacogenomics) based on gene
variation
2. Ligand fishing of "orphan G-protein-coupled receptors"
and structure-function analysis
Department of Chemogenomics
Professor
FUJII, Nobutaka, D.Pharm.Sci. (Kyoto Univ.)
Assistant Professor
OISHI, Shinya, D.Pharm.Sci. (Kyoto Univ.)
Outline of Teaching Activities
The Laboratory is responsible for undergraduate instruction
in chemical biology and bioorganic chemistry. The department provides graduate students with seminars, which review
and discuss recent research on chemical biology and functional genomics/proteomics. Laboratory practice in chemical
biology and chemical genomics are also provided.
Outline of Research Activities
The main research fields are as follows:
1. Functional studies on peptides/proteins, including anti-cancer and anti-viral peptides/proteins
2. Functional studies on peptidomimetics, targeting to chemokine receptors and GPR54
3. Chemical biology using specific chemical probes
Pharmaceutical Sciences 179
Department of Systems Biology
Professor
OKAMURA, Hitoshi, D.Med (Kyoto Prefectural University of
Medicine)
dates utilizing both chemoinformatics and bioinformatics
methods.
Associate Professor
DOI, Masao, D. Sci (Tokyo Univ)
Department of System Chemotherapy (Computational
Drug Design)
Professor
KITAURA, Kazuo, Ph.D. (Osaka City Univ.)
Assistant Professor
YAMAGUCHI, Yoshiaki, D. Bioscience (Kyoto Univ)
Associate Professor
MURATA, Katsumi, Ph.D. (Grad.Univ. Advanced Studies)
Outline of Teaching Activities
The Laboratory is responsible for undergraduate instruction
of Human Physiology and Pathophysiology. The department
provides graduate students with seminars, which review and
discuss with their own themes including medical and pharmacological fields. Laboratory practice in biological sciences
featuring circadian biology is also provided.
Outline of Teaching Activities
The Laboratory is responsible for undergraduate instruction
in physical chemistry (quantum chemistry and theory of
chemical bond and reaction). The Department provides graduate students with seminars, which review and discuss biomolecular simulation and structure based drug design. Laboratory practice in computational chemistry (electronic structure calculations and molecular dynamics simulations) is also
provided.
Outline of Research Activities
How TIME is generated and tuned in the body? We will
clarify the secret of generation and tuning of TIME in mammalian circadian system by multi-layered view at intracellular,
intercellular and individual levels. TIME is transmitted in
multilayer systems: 1) intracellular system of generation of
cyclic TIME, 2) Intercellular system for synchronizing TIME,
and 3) Symphony of TIME in individuals. Through clarifying
this integration network mechanism of TIME, we will develop
new drugs for tuning TIME.
Department of System Chemotherapy and Molecular Sciences
Professor
KAKEYA, Hideaki, D. Engineer. (Keio Univ.)
Associate Professor
HATTORI, Akira, D. Pharm. Sci. (Gifu Pharm. Univ.)
Outline of Teaching Activities
The Laboratory is responsible for instruction in natural
product chemistry, medicinal chemistry, and chemical biology
for undergraduate students. The department provides graduate
students with seminars, which review and discuss recent important natural product chemistry and chemical biology toward system chemotherapy. Laboratory practice in advanced
natural product chemistry, medicinal chemistry and chemical
biology is also provided.
Outline of Research Activities
The main research fields are as follows:
1. Advanced chemical biology research for establishing system chemotherapy in order to cure multi-factorial diseases;
e.g. cancer, immunodeficiency, diabetes, cardiac diseases,
and neuronal diseases.
2. Advanced natural product chemistry for identifying novel
bioactive small molecules.
3. Biosynthetic studies of useful secondary metabolites in microorganisms and medicinal plants, and their application to
combinatorial biosynthesis
4. Development of HCS (high-content screening) and HTS
(high throughput screening) technologies for identifying
useful bioactive small molecules).
5. Medicinal chemistry for development of new drug candi-
Outline of Research Activities
The main research fields are as follows:
1. Development of quantum chemical methods for very large
molecules
2. Theoretical studies of structure and function of biomolecules
3. Development of computational methods for drug design
4. Exploratory research of novel lead compounds by structure
based drug design
Department of Integrated Genomics
Professor
KANEHISA, Minoru, D.Sc. (Univ. of Tokyo)
Associate Professor
GOTO, Susumu, D.Eng. (Kyushu Univ.)
Assistant Professor
HATTORI, Masahiro, D.Sc. (Kyoto Univ.)
Assistant Professors
TOKIMATSU, Toshiaki, D.Agr. (Kyoto Univ.)
t
KOTERA, Masaaki, D.Sc. (Kyoto Univ.)
Outline of Teaching Activities
The Department provides graduate students with bioinformatics courses relevant to pharmaceutical sciences, including
sequence analysis, 3D structure analysis, genome information
analysis, omics data analysis, pathway analysis, and chemoinformatics.
Outline of Research Activities
The main research fields are as follows:
1. Development of bioinformatics technologies for integrated
analysis of genomics and chemistry
2. Drug target discovery from genomes through pathway
analysis
3. Drug lead discovery from genomes through natural products
180
Department of Computational Genomics
Professor
MAMITSUKA, Hiroshi, D. Sci. (University of Tokyo)
Assistant Professors
TAKIGAWA, Ichigaku, D.Eng. (Hokkaido Univ.)
SHIGA, Motoki, D.Eng. (Gifu Univ.)
Outline of Teaching Activities
This department is responsible for the following subjects in
undergraduate as well as post-graduate courses: bioinformatics, computational biology, systems biology, pharmacoinformatics, computational genomics, chemoinformatics, and general techniques in computer science, like machine learning,
data mining, pattern recognition and more general techniques
in artificial intelligence.
Outline of Research Activities
With the recent advancement of experimental techniques in
molecular biology, research in modern life science is shifting
to the comprehensive understanding of a biological mechanism consisting of a variety of molecules. Our focus is placed
on molecular mechanisms in biological phenomena, represented by biological networks such as metabolic and signal
transduction pathways. Our research objective is to develop
techniques based on computer science and/or statistics to systematically understand biological entities at the cellular and
organism level.
5. CONTRIBUTED CHAIRS
Department of Neuroscience for Drug Discovery (Endowed chair)
Professor
SUGIMOTO, Hachiro, D.Pharm.Sci. (Hiroshima Univ.)
Associate Professor
NIIDOME, Tetsuhiro, D.Pharm.Sci. (Kyushu Univ.)
Lecturer
KIHARA, Takeshi, D.Med.Sci. (Kyoto Univ.)
Outline of Teaching Activities:
The Laboratory focuses on development of new medicines
targeting neurological diseases with the primary aim of developing new anti-Alzheimer’s drugs. The laboratory is responsible for providing training to graduate students in this
field of study. The laboratory provides graduate students with
advanced lectures in the mechanism of neurodegeneration
based upon the beta-amyloid and cholinergic hypotheses. The
discovery of seed compounds is the most important in drug
development and the laboratory provides instructions and
training in this area focusing on natural products. The laboratory also studies neurogenesis such as reconstruction of the
neuron or glia which would have the potential to recover brain
functions lost in cerebrovascular or neurodegenerative diseases. In-house seminars, reviews and discussions of recent
important literatures are provided.
Outline of Research Activities:
The main research fields are as follows:
1. To elucidate the cause of neurodegeneration, e.g. Alz-
heimer’s disease or Parkinson’s disease.
2. To develop new drugs for neurodegenerative diseases, especially anti-Alzheimer’s drugs.
3. To study the neuroprotective effect of acetylcholinesterase
inhibitors against beta-amyloid or glutamate-induced cell
death in vitro.
4. To study the mechanism underlying the (i) self-renewal/cell
death/differentiation of neural stem cells, (ii) differentiation
of microglia, and (iii) interaction between neural stem cells
and microglia.
Department of Nanobio Drug Discovery
Professor
SHIMIZU, Kazuharu, PhD. (Engineering, Tokyo Univ.)
Associate Professor
SATO, Fumiaki, MD. & PhD (Medicine, Kyoto Univ.)
Assistant Professor
TSUCHIYA, Soken, PhD. (Pharm., Kyoto Univ.)
Outline of Teaching Activity
The Laboratory is responsible for graduate instruction in
DNA microarray-related research covering the basic concepts,
wet lab techniques, bioinformatic analysis of DNA microarray.
The Department provides graduate students with seminars,
which review and discuss recent important nanobio technology. Laboratory practice in advance microarray and bioinformatic analysis is also provided.
Outline of Research Activity
1. From mRNA expression profiling to “Taylor-made” therapy.
2. Functional analysis of microRNA
3. MicroRNA profiling for clinical diagnosis
4. MicroRNA therapy
5. Epigenetic control of mRNA and microRNA expression
6. Omics research using a next generation high throughput
sequencer.
Department of Systems Bioscience for Drug Discovery
http://pharminfo.pharm.kyoto-u.ac.jp/
Professor
OKUNO, Yasushi, D.Pharm.Sci. (Kyoto Univ.)
Associate Professor
SEGI-NISHIDA, Eri, D.Pharm.Sci. (Kyoto Univ.)
Outline of Teaching Activities
The Laboratory is responsible for general instruction in
systems biology, molecular biology, bio/chemo-informatics
and neuropharmacology for graduate students. The Department provides graduate students with seminars and laboratory
practice in systems biology and molecular biology for drug
discovery.
Outline of Research Activities
1. Development of drug design theories based on chemical
genomics and polypharmacology
2. Development of systems biological approaches for simulating of disease processes and drug actions
3. Identification of the molecular and cellular mechanisms t
Pharmaceutical Sciences 181
hat underlie the actions of antidepressant drugs and stress
4. Exploration of the role of prostanoid in the stress responses
and mood disorder
6. EDUCATION AND RESEARCH FACILITIES
1. Statistical modeling and simulation for individualized clinical drug therapy, and clinical pharmacology in drug development.
2. Clinical and non-clinical pharmacokinetic / pharmacodynamic analysispharmacy (clinical pharmacology, pharmacotherapy, and clinical drug development), and for practice
of clinical data analysis.
Center for Integrative Education of Pharmacy Frontier
Department of Integrative Education of Pharmacy
Professor
SAKAEDA, Toshiyuki, D.Pharm.Sci. (Kyoto Univ.)
Frontier Education Center Medical staff GP
Professor
SAJI, Hideo, D.Pharm.Sci. (Kyoto Univ.)
Assistant Professor
KUBOTA, Yoshie
Outlines of Teaching Activities
The Department is responsible for general undergraduate
instruction and practice in clinical pharmacy, and for establishment the internet education system, i.e., “navigation system” and “e-learning system”, where general and/or professional lectures and their related tools as well as the information provided by professional staffs are disclosed for the students and community medical personnel, in collaboration with
staffs of the faculty. Tutorial education programs are also
provided for undergraduate students, which is the program of
problem-based learning with small group discussion.
Outlines of Teaching Activities
The staffs are responsible for the program to support
medical education corresponding to community health care
needs and other social needs with newly developed novel
subprograms as follows.
1. Navigation systems, where lectures and related tools provided by professional staff are disclosed to students via
internet system.
2. Grid tutorial education program, which is the program of
Outlines of Research Activities
1. Personalized medicine via therapeutic drug monitoring
2. Personalized medicine via pretreatment profiling of genetic
properties
3. Personalized medicine via protein profiling
4. Drug discovery via transcriptome and proteome analysis
Department of Advanced Pharmaceutical Sciences
and Biotechnology
Associate Professor
TOCHIKURA,Tadafumi, D.V.M.,Ph.D. (Yamaguchi Univ.)
problem-based learning with small group discussion.
3. English understanding and speaking program, provided by
professional staff including native speakers.
4. Early exposure programs, including volunteer working in
university and/or general hospitals and pharmacy, and visits
to The Pharmaceuticals and Medical Devices Agency and
other official organizations.
5. Integration programs, the co-education systems with students of the departments other than the Department of
Pharmaceutical Sciences.
Outline of Teaching Activities
The Department is responsible for instruction in the training of undergraduate and graduate students in the areas of basic virology particularly associated with zoonotic potential,
and applied virology focusing on virus-derived gene delivery
system.
Outline of Research Activities
1.Investigation into the mechanism for the acquisition of human cell tropism by feline immunodeficiency virus.
2.Study on the development of tissue-specific feline immunodeficiency virus vectors for use in human gene therapy.
Department of Integrative Clinical Pharmacy
Associate Professor
YANO, Yoshitaka, D.Pharm.Sci. (Kyoto Univ.)
Experimental Station For Medicinal Plants
(affiliated with the Graduate School of Pharmaceutical
Sciences)
Associate Professor
ITO, Michiho, D.Pharm.Sci. (Kyoto Univ.)
The Experimental Station for Medicinal Plants covers an
area of about 3000m2, and was founded in 1973. The station
keeps various medicinal plants for education of undergraduate
and graduate students, and for research activities. Some
tropical plants and others are grown under controlled conditions in the station's greenhouse. The Station can functions not
only as a specimen garden but also as an experimental institute.
Outline of Teaching Activities
The Department is responsible for creating integrative
educational programs and e-learning systems for clinical
pharmacy (clinical pharmacology, pharmacotherapy, and
clinical drug development), and for practice of clinical data
analysis.
Outline of Teaching Activities
The Station offers undergraduate instruction in the fundamental knowledge of medicinal plants (ethnobotany, taxonomy and chemotaxonomy, morphology, genetics, breeding,
biosynthesis of secondary metabolites and biotechnology).
Outline of Research Activities
Outline of Research Activities
182
Main research fields are as follows:
1. Collection and propagation of important medicinal plant
resources
2. Origin and phylogenetic relationship of the wild and cultivated Perilla plants
3. Field research of traditional medicines in Asian countries
Support Program for Improving Graduate School Education
(Graduate School of Pharmaceutical Sciences/Biostudies)
Assistant Professors
ONOHARA, Naoya, D.Pharm.Sci. (Kyushu Univ.)
YAMAUCHI, Hajime, D.Pharm.Sci. (Kyoto Univ.)
Service Innovation Program
Assistant Professors
SUZUKI, Chigure, M.D. (Juntendo Univ.), D.Med.Sci. (Osaka
Univ.)
INOKUMA, Tsubasa, M.Pharm.Sci. (Kyoto Univ.)
Outlines of Teaching Activities
The staffs are responsible for general undergraduate and
graduate instruction and practice concerning the R&D activities in pharmaceutical companies and optimization of community pharmacotherapy, in collaboration with staffs of the
faculty.
The novel education programs are established for
the students, and their goals are to become the clinical research coordinators, and community pharmacists and other
medical staffs, respectively. Additionally, we aim at fostering novel personnel who can promote the innovation in
Japanese health care system. The program is supported by
the Ministry of Education, Culture, Sports, Science and
Technology, Japan.