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Christine Carico (213) 663-2827 [email protected] PROFILE Academic Fellow with over 7 years of experience in cancer biology and clinical neurosurgical research with a focus on signaling pathways contributing to the initiation and maintenance of malignant transformation. Primary professional objectives include development of novel therapies and prognostic markers for the management of human cancers. EDUCATION Bachelor of Science, Neuroscience 12/2014 University of California, Los Angeles, Los Angeles, CA Core coursework includes molecular, cellular, systems and developmental neurobiology, neuroanatomy, electrophysiology, cognitive neuropsychology, and biochemistry CORE COMPETENCIES Model organisms: mouse handling, injections (subcutaneous, intraperitoneal), euthanasia (isoflurane, ketamine drug cocktail, carbon dioxide, cervical dislocation), perfusions, organ harvest (heart, lungs, liver, spleen, kidneys), intracranial tumor inoculations for xenogeneic, allogenic and syngeneic mouse tumor models; bacterial cell culture; frozen sample sectioning via cryostat (7-10µm), H&E staining DNA handling, manipulation and cloning strategies: transfection, transduction, DNA and RNA isolation, PCR, restriction digests, ligations, electrophoresis Cell culture: thawing, seeding, passaging, freezing cell lines (both primary human brain tumor and primary human umbilical cord hematopoietic stem cells); stem cell isolation (c-kit+ leukemia stem cells and hematopoietic stem cells from umbilical cord blood) Protein work: protein purification, SDS-PAGE, Western blot analysis RELEVANT PROFESSIONAL EXPERIENCE Research Associate I October 2015-March 2016 Cedars-Sinai Medical Center Los Angeles, CA Department of Neurosurgery Precision Medicine Initiative at Cedars-Sinai Medical Center: Investigating the potential for clinical application of a mathematical algorithm modeling signaling pathways in cancerous cells for more comprehensive and targeted drug treatment approach based on sequence data from individual patient tumors Washington Scholar at the Nanomedicine Research Center 2013-2015 Cedars-Sinai Medical Center Los Angeles, CA Department of Neurosurgery Investigated the efficacy of nanobioconjugates as targeted drug delivery vehicles in human cancer models (glioblastoma, metastatic brain tumor and breast tumor models) Studied the effect of inhibition of laminin 411 expression in signaling pathways and tumor shrinkage in primary brain tumor mouse models Assessed the effect of anti CTLA-4 antibody on immune activation in syngeneic breast-brain metastatic mouse model and mouse breast (flank) tumor model Clinical Research Assistant, Center for Neurosurgical Outcomes Research 2011-2013 Cedars-Sinai Medical Center Los Angeles, CA Department of Neurosurgery Conducted literature reviews, analyzed SAS data and wrote manuscripts in collaborative effort to report demographic, treatment and outcome trends in a variety of neurosurgical cohorts (i.e. glioblastoma patients, etc) from both internal and national databases in an effort to provide a comprehensive clinical picture of the current field of neurosurgery Utilized internal databases to establish correlations between signaling pathway protein expression and outcome (namely overall survival) in an effort to provide a portrait of the clinical implications of aberrant signaling pathways Research Assistant (Student) 2011-2012 University of California, Los Angeles, Los Angeles CA Department of Chemistry and Biochemistry Designed, executed and troubleshot a cloning strategy – selected vector, restriction sites, and designed primer for plasmid containing desired construct for use in investigating activity in the Ras signaling pathway in human cancers Student Research Assistant 2008 Stanford Hospital and Clinics, Palo Alto, CA Department of Neurosurgery (Guzman Lab) Investigated the efficacy of neural stem cells in post- ischemic stroke rehabilitation in rat models Student Research Assistant 2007-2008 Stanford University, Palo Alto, CA School of Medicine (Cleary Lab) Investigated the effects of the miR-17 polycistron on leukemia stem cell (LSC) potential LICENSES AND CERTIFICATIONS National Registered Emergency Medical Technician (Registry #: E3195632) California State Certified Emergency Medical Technician (Registry #: E093047) AWARDS AND HONORS Washington Gifted Scholars Program at Cedars-Sinai Medical Center 2013-2015 Investigate the efficacy of nanobioconjugates as targeted drug delivery vehicles in mouse brain tumor models Undergraduate Cancer Research Training Program 2010 Charles Drew University of Medicine and Science Researched the efficacy with which monocytes can be derived from hematopoietic stem cells through culturing umbilical cord-derived HSCs in specified cytokines ABSTRACTS AND PRESENTATIONS Miriam Nuno, Debraj Mukherjee, Christine Carico, Chirag Patil. The Effect of Centralization of Caseload for Primary Brain Tumor Surgeries: Updated Trends from 2001-2007. 2011 CNS Conference Washington DC (oral presentation given by Debraj Mukherjee) Debraj Mukherjee, Miriam Nuno, Christine Carico, Chirag Patil. Predictors of Inpatient Complications and Outcomes Following Surgical Resection of Hypothalamic Hamartomas. 2011 CNS Conference Washington DC (poster presentation) Christine Carico, Miriam Nuno, Debraj Mukherjee, Adam Elramsisy, JocelynnDantis, Jethro Hu, Jeremy Rudnick, John S. Yu, Keith L. Black, Serguei I. Bannykh, Chirag G. Patil. Loss of PTEN is Not Associated with Poor Survival in the Newly Diagnosed Glioblastoma Patients of the Temozolomide Era. 2012 AANS Conference, Miami, FL. (ePoster presentation) Miriam Nuno, Kristen Nosova, Christine Carico, Debraj Mukherjee, Jeremy D. Rudnick, Jethro Hu, John S. Yu, Keith L. Black, Chirag G. Patil. Patterns of Care and Prognosis in Patients with Anaplastic Astrocytoma. 2012 CNS Conference, Chicago, Il. (poster presentation) Kurtis Birch, Miriam Nuno, Debraj Mukherjee, Adam Elramsisy, Christine Carico, Shivanand Lad, Maxwell Boakye, Keith L. Black, Chirag G. Patil. Comparison of Treatment Patterns and Long-Term Survival between Four Histological Subtypes of Anaplastic Glioma. CNS 2012, Chicago, Il. (poster presentation) Chirag Patil, Holly Dickinson, Christine Carico, J. Manuel Sarmiento, Diana Ly, Keith Black, Miriam Nuno. The Role of Early Readmission upon Survival Among Newly Diagnosed Glioblastoma Patients. AANS 2013 New Orleans, LA J. Manuel Sarmiento, Diana Ly, Jaswinder Jutla, Alicia Ortega, Christine Carico, Holly Dickinson, Chirag Patil, Jethro Hu. Efficacy of bevacizumab at first vs subsequent recurrence.SNO 2013 J. Manuel Sarmiento, Debraj Mukherjee, Jason Pia, Diana Ly, Miriam Nuno, Christine Carico, Keith Black, Chirag Patil. Extent of Resection Threshold for Recurrent Glioblastoma Patients. AANS 2014 San Francisco, CA Debraj Mukherjee, Alicia Ortega, Christine Carico, Miriam Nuno, Chirag Patil. Pediatric Glioblastoma: An Analysis of 281 Cases from a Multicenter, Prospective Cohort with Long-Term Follow-Up. Submitted: CNS 2014 (pending review) Christine Carico, Alicia Ortega, Miriam Nuno, Chirag Patil, Debraj Mukherjee. Tumor of the choroid plexus: A population-based analysis of the National Cancer Database. Submitted: CNS 2014 (accepted for ePoster presentation CNS 2014) Debraj Mukherjee, Alicia Ortega, Kristin Nosova, Christine Carico, Miriam Nuno, Chirag Patil. Multimodal Therapy for Tumors of the Clivus: An Analysis of 216 Chordomas and Chondrosarcomas from a Multicenter, Prospective Cohort with Long-Term Follow-Up. Submitted: CNS 2014 (accepted for ePoster presentation CNS 2014) PEER-REVIEWED PUBLICATIONS Wong P, Iwasaki M, Somervaille TC, Ficara F, Carico C, Arnold C, Chen CZ, Cleary ML. The miR-1792 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression. Cancer Res. 2010 May 1;70(9):3833-42. Mukherjee D, Carico C, Nuno M, Patil CG. Predictors of inpatient complications and outcomes following surgical resection of hypothalamic hamartomas.SurgNeurol Int. 2011;2:105. Carico C, Nuno M, Mukherjee D, Elramsisy A, Dantis J, Hu J, Rudnick J, Yu JS, Black KL, Bannykh SI, Patil CG. Loss of PTEN is not associated with poor survival in newly diagnosed glioblastoma patients of the temozolomide era. PLoS One.2012;7(3):e33684. Nuno M, Mukherjee D, Carico C, Elramsisy A, Veeravagu A, Black KL, Patil CG. The effect of centralization of caseload for primary brain tumor surgeries: trends from 2001-2007. ActaNeurochir (Wein). 2012 Aug; 154(8):1343-50. Patil CG, Nuno M, Elramsisy A, Mukherjee D, Carico C, Dantis J, Hu J, Yu JS, Fan X, Black KL, Bannykh SI. High levels of phosphorylated MAP kinase are associated with poor survival among patients with glioblastoma during the temozolomide era. NeuroOncol. 2013 Jan;15(1):104-111. Dickinson H, Carico C, Nuno M, Nosova K, Elramsisy A, Patil CG. The effect of weight in the outcomes of meningioma patients.SurgNeurol Int. 2013 April 3;4:45. Dickinson H, Carico C, Nuno M, Mukherjee D, Ortega A, Black KL, Patil CG. Unplanned readmissions and survival following brain tumor surgery.J Neurosurg. 2015 Jan;122(1):61-8 Nuno M*, Carico C*, Mukherjee D, Ly D, Ortega A, Black KL, Patil CG. Association between inhospital adverse events and mortality for patients with brain tumors? J Neurosurg. 2015 May 22:1-9 Varshneya K, Carico C, Ortega A, Patil CG. The Efficacy of Ketogenic Diet and Associated Hypoglycemia as an Adjuvant Therapy for High-Grade Gliomas: A Review of the Literature. Cureus. 2015 Feb 27;7(2):e251