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Christine Carico
(213) 663-2827
[email protected]
PROFILE
Academic Fellow with over 7 years of experience in cancer biology and clinical neurosurgical research
with a focus on signaling pathways contributing to the initiation and maintenance of malignant
transformation. Primary professional objectives include development of novel therapies and prognostic
markers for the management of human cancers.
EDUCATION
Bachelor of Science, Neuroscience
12/2014
University of California, Los Angeles, Los Angeles, CA
 Core coursework includes molecular, cellular, systems and developmental neurobiology,
neuroanatomy, electrophysiology, cognitive neuropsychology, and biochemistry
CORE COMPETENCIES
 Model organisms: mouse handling, injections (subcutaneous, intraperitoneal), euthanasia
(isoflurane, ketamine drug cocktail, carbon dioxide, cervical dislocation), perfusions, organ
harvest (heart, lungs, liver, spleen, kidneys), intracranial tumor inoculations for xenogeneic,
allogenic and syngeneic mouse tumor models; bacterial cell culture; frozen sample sectioning via
cryostat (7-10µm), H&E staining
 DNA handling, manipulation and cloning strategies: transfection, transduction, DNA and RNA
isolation, PCR, restriction digests, ligations, electrophoresis
 Cell culture: thawing, seeding, passaging, freezing cell lines (both primary human brain tumor
and primary human umbilical cord hematopoietic stem cells); stem cell isolation (c-kit+ leukemia
stem cells and hematopoietic stem cells from umbilical cord blood)
 Protein work: protein purification, SDS-PAGE, Western blot analysis
RELEVANT PROFESSIONAL EXPERIENCE
Research Associate I
October 2015-March 2016
Cedars-Sinai Medical Center
Los Angeles, CA
Department of Neurosurgery
 Precision Medicine Initiative at Cedars-Sinai Medical Center: Investigating the potential for
clinical application of a mathematical algorithm modeling signaling pathways in cancerous cells
for more comprehensive and targeted drug treatment approach based on sequence data from
individual patient tumors
Washington Scholar at the Nanomedicine Research Center
2013-2015
Cedars-Sinai Medical Center
Los Angeles, CA
Department of Neurosurgery
 Investigated the efficacy of nanobioconjugates as targeted drug delivery vehicles in human cancer
models (glioblastoma, metastatic brain tumor and breast tumor models)
 Studied the effect of inhibition of laminin 411 expression in signaling pathways and tumor
shrinkage in primary brain tumor mouse models
 Assessed the effect of anti CTLA-4 antibody on immune activation in syngeneic breast-brain
metastatic mouse model and mouse breast (flank) tumor model
Clinical Research Assistant, Center for Neurosurgical Outcomes Research
2011-2013
Cedars-Sinai Medical Center
Los Angeles, CA
Department of Neurosurgery
 Conducted literature reviews, analyzed SAS data and wrote manuscripts in collaborative effort to
report demographic, treatment and outcome trends in a variety of neurosurgical cohorts (i.e.
glioblastoma patients, etc) from both internal and national databases in an effort to provide a
comprehensive clinical picture of the current field of neurosurgery
 Utilized internal databases to establish correlations between signaling pathway protein expression
and outcome (namely overall survival) in an effort to provide a portrait of the clinical
implications of aberrant signaling pathways
Research Assistant (Student)
2011-2012
University of California, Los Angeles, Los Angeles CA
Department of Chemistry and Biochemistry
 Designed, executed and troubleshot a cloning strategy – selected vector, restriction sites, and
designed primer for plasmid containing desired construct for use in investigating activity in the
Ras signaling pathway in human cancers
Student Research Assistant
2008
Stanford Hospital and Clinics, Palo Alto, CA
Department of Neurosurgery (Guzman Lab)
 Investigated the efficacy of neural stem cells in post- ischemic stroke rehabilitation in rat models
Student Research Assistant
2007-2008
Stanford University, Palo Alto, CA
School of Medicine (Cleary Lab)
 Investigated the effects of the miR-17 polycistron on leukemia stem cell (LSC) potential
LICENSES AND CERTIFICATIONS
 National Registered Emergency Medical Technician (Registry #: E3195632)
 California State Certified Emergency Medical Technician (Registry #: E093047)
AWARDS AND HONORS
Washington Gifted Scholars Program at Cedars-Sinai Medical Center
2013-2015
 Investigate the efficacy of nanobioconjugates as targeted drug delivery vehicles in mouse brain
tumor models
Undergraduate Cancer Research Training Program
2010
Charles Drew University of Medicine and Science
 Researched the efficacy with which monocytes can be derived from hematopoietic stem cells
through culturing umbilical cord-derived HSCs in specified cytokines
ABSTRACTS AND PRESENTATIONS
Miriam Nuno, Debraj Mukherjee, Christine Carico, Chirag Patil. The Effect of Centralization of
Caseload for Primary Brain Tumor Surgeries: Updated Trends from 2001-2007. 2011 CNS Conference
Washington DC (oral presentation given by Debraj Mukherjee)
Debraj Mukherjee, Miriam Nuno, Christine Carico, Chirag Patil. Predictors of Inpatient Complications
and Outcomes Following Surgical Resection of Hypothalamic Hamartomas. 2011 CNS Conference
Washington DC (poster presentation)
Christine Carico, Miriam Nuno, Debraj Mukherjee, Adam Elramsisy, JocelynnDantis, Jethro Hu,
Jeremy Rudnick, John S. Yu, Keith L. Black, Serguei I. Bannykh, Chirag G. Patil. Loss of PTEN is Not
Associated with Poor Survival in the Newly Diagnosed Glioblastoma Patients of the Temozolomide Era.
2012 AANS Conference, Miami, FL. (ePoster presentation)
Miriam Nuno, Kristen Nosova, Christine Carico, Debraj Mukherjee, Jeremy D. Rudnick, Jethro Hu,
John S. Yu, Keith L. Black, Chirag G. Patil. Patterns of Care and Prognosis in Patients with Anaplastic
Astrocytoma. 2012 CNS Conference, Chicago, Il. (poster presentation)
Kurtis Birch, Miriam Nuno, Debraj Mukherjee, Adam Elramsisy, Christine Carico, Shivanand Lad,
Maxwell Boakye, Keith L. Black, Chirag G. Patil. Comparison of Treatment Patterns and Long-Term
Survival between Four Histological Subtypes of Anaplastic Glioma. CNS 2012, Chicago, Il. (poster
presentation)
Chirag Patil, Holly Dickinson, Christine Carico, J. Manuel Sarmiento, Diana Ly, Keith Black, Miriam
Nuno. The Role of Early Readmission upon Survival Among Newly Diagnosed Glioblastoma Patients.
AANS 2013 New Orleans, LA
J. Manuel Sarmiento, Diana Ly, Jaswinder Jutla, Alicia Ortega, Christine Carico, Holly Dickinson,
Chirag Patil, Jethro Hu. Efficacy of bevacizumab at first vs subsequent recurrence.SNO 2013
J. Manuel Sarmiento, Debraj Mukherjee, Jason Pia, Diana Ly, Miriam Nuno, Christine Carico, Keith
Black, Chirag Patil. Extent of Resection Threshold for Recurrent Glioblastoma Patients. AANS 2014
San Francisco, CA
Debraj Mukherjee, Alicia Ortega, Christine Carico, Miriam Nuno, Chirag Patil. Pediatric Glioblastoma:
An Analysis of 281 Cases from a Multicenter, Prospective Cohort with Long-Term Follow-Up.
Submitted: CNS 2014 (pending review)
Christine Carico, Alicia Ortega, Miriam Nuno, Chirag Patil, Debraj Mukherjee. Tumor of the choroid
plexus: A population-based analysis of the National Cancer Database. Submitted: CNS 2014 (accepted
for ePoster presentation CNS 2014)
Debraj Mukherjee, Alicia Ortega, Kristin Nosova, Christine Carico, Miriam Nuno, Chirag Patil.
Multimodal Therapy for Tumors of the Clivus: An Analysis of 216 Chordomas and Chondrosarcomas
from a Multicenter, Prospective Cohort with Long-Term Follow-Up. Submitted: CNS 2014 (accepted for
ePoster presentation CNS 2014)
PEER-REVIEWED PUBLICATIONS
Wong P, Iwasaki M, Somervaille TC, Ficara F, Carico C, Arnold C, Chen CZ, Cleary ML. The miR-1792 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression.
Cancer Res. 2010 May 1;70(9):3833-42.
Mukherjee D, Carico C, Nuno M, Patil CG. Predictors of inpatient complications and outcomes
following surgical resection of hypothalamic hamartomas.SurgNeurol Int. 2011;2:105.
Carico C, Nuno M, Mukherjee D, Elramsisy A, Dantis J, Hu J, Rudnick J, Yu JS, Black KL, Bannykh SI,
Patil CG. Loss of PTEN is not associated with poor survival in newly diagnosed glioblastoma patients of
the temozolomide era. PLoS One.2012;7(3):e33684.
Nuno M, Mukherjee D, Carico C, Elramsisy A, Veeravagu A, Black KL, Patil CG. The effect of
centralization of caseload for primary brain tumor surgeries: trends from 2001-2007. ActaNeurochir
(Wein). 2012 Aug; 154(8):1343-50.
Patil CG, Nuno M, Elramsisy A, Mukherjee D, Carico C, Dantis J, Hu J, Yu JS, Fan X, Black KL,
Bannykh SI. High levels of phosphorylated MAP kinase are associated with poor survival among
patients with glioblastoma during the temozolomide era. NeuroOncol. 2013 Jan;15(1):104-111.
Dickinson H, Carico C, Nuno M, Nosova K, Elramsisy A, Patil CG. The effect of weight in the
outcomes of meningioma patients.SurgNeurol Int. 2013 April 3;4:45.
Dickinson H, Carico C, Nuno M, Mukherjee D, Ortega A, Black KL, Patil CG. Unplanned readmissions
and survival following brain tumor surgery.J Neurosurg. 2015 Jan;122(1):61-8
Nuno M*, Carico C*, Mukherjee D, Ly D, Ortega A, Black KL, Patil CG. Association between inhospital adverse events and mortality for patients with brain tumors? J Neurosurg. 2015 May 22:1-9
Varshneya K, Carico C, Ortega A, Patil CG. The Efficacy of Ketogenic Diet and Associated
Hypoglycemia as an Adjuvant Therapy for High-Grade Gliomas: A Review of the Literature. Cureus.
2015 Feb 27;7(2):e251