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Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 0 Chapter 2 Chemistry of Life Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 1 Objectives • Define the terms atom, element, molecule, and compound. • Describe the structure of an atom. • Compare and contrast ionic and covalent types of chemical bonding. • Distinguish between organic and inorganic chemical compounds. Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 2 Objectives (cont’d.) • Discuss the chemical characteristics of water. • Explain the concept of pH. • Discuss the structure and function of the following types of organic molecules: carbohydrate, lipid, protein, and nucleic acid. Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 3 Chapter 2 Lesson 2.1 Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 4 Levels of Chemical Organization • Atoms – Nucleus—central core of atom • Proton—positively charged particle in nucleus • Neutron—non-charged particle in nucleus • Atomic mass—number of protons in the nucleus; determines the type of atom Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 5 Levels of Chemical Organization • Atoms – Energy levels—regions surrounding atomic nucleus that contain electrons • Electron—negatively charged particle • May contain up to 8 electrons in each level • Energy increases with distance from nucleus Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 6 Levels of Chemical Organization • Elements, molecules, and compounds – Element—a pure substance; made up of only one kind of atom – Molecule—a group of atoms bound together in a group – Compound—substances whose molecules have more than one kind of atom Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 7 Chemical Bonding • Chemical bonds form to make atoms more stable – Outermost energy level of each atom is full – Atoms may share electrons, or donate or borrow them to become stable Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 8 Chemical Bonding • Ionic bonds – Ions form when an atom gains or loses electrons in its outer energy level to become stable • Positive ion—has lost electrons; indicated by superscript positive sign(s), as in Na+ or Ca++ • Negative ion—has gained electrons; indicated by superscript negative sign(s), as in Cl– Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 9 Chemical Bonding • Ionic bonds – Ionic bonds form when positive and negative ions attract each other because of electrical attraction – Electrolyte—molecule that dissociates (breaks apart) in water to form individual ions; an ionic compound Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 10 Chemical Bonding • Covalent bonds – Covalent bonds form when atoms shared their outer energy to fill up and thus become stable – Covalent bonds do not ordinarily easily dissociate in water Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 11 Chapter 2 Lesson 2.2 Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 12 Inorganic Chemistry • Organic molecules contain carbon-carbon covalent bonds and/or carbon-hydrogen covalent bonds; inorganic molecules do not • Examples of inorganic molecules: water and some acids, bases, and salts Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 13 Inorganic Chemistry • Water – Water is a solvent (liquid into which solutes are dissolved), forming aqueous solutions in the body Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 14 Inorganic Chemistry – Water is involved in chemical reactions • Dehydration synthesis—chemical reaction in which water is removed from small molecules so they can be strung together to form a larger molecule • Hydrolysis—chemical reaction in which water is added to the subunits of a large molecule to break it apart into smaller molecules • Chemical reactions always involve energy transfers, as when energy is used to build ATP molecules • Chemical equations show how reactants interact to form products; arrows separate the reactants from the products Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 15 Inorganic Chemistry • Acids, bases, and salts – Water molecules dissociate to form equal amounts of H+ (hydrogen ion) and OH– (hydroxide ion) – Acid—substance that shifts the H+/OH– balance in favor of H+; opposite of base – Base—substance that shifts the H+/OH– balance against H+; also known as an alkaline; opposite of acid Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 16 Inorganic Chemistry • Acids, bases, and salts – Ph—mathematical expression of relative H+ concentration in an aqueous solution • 7 is neutral (neither acid nor base) • Ph values above 7 are basic; ph values below 7 are acidic Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 17 Inorganic Chemistry • Acids, bases, and salts – Neutralization occurs when acids and bases mix and form salts – Buffers are chemical systems that absorb excess acids or bases and thus maintain a relatively stable ph Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 18 Chapter 2 Lesson 2.3 Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 19 Organic Chemistry • Carbohydrates—sugars and complex carbohydrates) – Contain carbon (C), hydrogen (H), oxygen (O) – Made up of six-carbon subunits called monosaccharides or single sugars (e.g., glucose) – Disaccharide—double sugar made up of two monosaccharide units (e.g., sucrose, lactose) Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 20 Organic Chemistry • Carbohydrates—sugars and complex carbohydrates) – Polysaccharide—complex carbohydrate made up of many monosaccharide units (e.g., glycogen made up of many glucose units) – Function of carbohydrates is to store energy for later use Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 21 Organic Chemistry • Lipids—fats and oils – Triglycerides • Made up of one glycerol unit and three fatty acids • Store energy for later use Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 22 Organic Chemistry • Lipids—fats and oils – Phospholipids • Similar to triglyceride structure, except with only two fatty acids, and with a phosphorus-containing group attached to glycerol • The head attracts water and the double tail does not, thus forming stable double layers (bilayers) in water • Form membranes of cells Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 23 Organic Chemistry • Lipids—fats and oils – Cholesterol • Molecules have a steroid structure made up of multiple rings • Cholesterol stabilizes the phospholipid tails in cellular membranes and is also converted into steroid hormones by the body Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 24 Organic Chemistry • Proteins – Very large molecules made up of amino acids held together in long, folded chains by peptide bonds – Structural proteins • Form structures of the body • Collagen is a fibrous protein that holds many tissues together • Keratin forms tough, waterproof fibers in the outer layer of the skin Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 25 Organic Chemistry • Proteins – Functional proteins • Participate in chemical processes • Examples: hormones, cell membrane channels and receptors, enzymes • Enzymes – Catalysts—help chemical reactions occur – Lock-and-key model—each enzyme fits a particular molecule that it acts on as a key fits into a lock Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 26 Organic Chemistry • Proteins – Proteins can combine with other organic molecules to form glycoproteins or lipoproteins Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 27 Organic Chemistry • Nucleic acids – Made up of nucleotide units • Sugar (ribose or deoxyribose) • Phosphate • Nitrogen base (adenine, thymine or uracil, guanine, cytosine) Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 28 Organic Chemistry • Nucleic acids – DNA (deoxyribonucleic acid) • Used as the cell’s “master code” for assembling proteins. • Uses deoxyribose as the sugar and A, T (not U), C, and G as bases • Forms a double helix shape Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 29 Organic Chemistry • Nucleic acids – RNA (ribonucleic acid) • Used as a temporary “working copy” of a gene (portion of the DNA code) • Uses ribose as the sugar and A, U (not T), C, and G as bases Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 30 Organic Chemistry • Nucleic acids – By directing the formation of structural and functional proteins, nucleic acids ultimately direct overall body structure and function Copyright © 2007, 2005, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. 31