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PROSTATE CANCER – BACK TO FUTURE WAKE FOREST UNIVERSITY – THIRD ANNUAL SYMPOSIUM APRIL 15 & 16, 2016 Day 1 – Friday, April 15, 2016 Introduction 7:50 – 7:55 AM Welcome Address Anthony Atala, 7:55 – 8:00 AM Overview of the Symposium K. C. Balaji Session 1: 8:00 AM – 10:10 AM Category – Metastatic Prostate Cancer Moderators: Christopher Thomas and Paul Rennie 8:00 – 8:30 Chemotherapy; First or Last in Metastatic Prostate Cancer? Christopher Sweeney 8:30 – 9:00 Advances in Immunotherapy in Prostate Cancer Purnima Dubey 9:00 – 9:30 PIVOT Study- An Analysis Timothy Wilt 9:30 – 9:50 Should We Classify Metastatic Prostate Cancer; Nodes, Bones or Visceral Metastasis K. C. Balaji 9:50 – 10:10 Panel Discussion 10:10 – 10:30 - BREAK Session II: 10:30 AM – 12:10 PM Category – Resistance in Castration Resistant Prostate Cancer Moderators: Andrew Armstrong and Christopher Sweeney 10:30 – 11:00 CTC as Biomarkers to Study Resistance to Treatment in CRPC Christopher Thomas 11:00 – 11:30 Strategies to Overcome Resistance to Antiandrogens to Prostate Cancer Paul Rennie 11:30 – 11:50 Role of Surgery or Radiation in Patients with Oligometastatic Prostate Cancer Rhonda Bitting 11:50 – 12:10 Panel Discussion 12:10 – 1:00 LUNCH Session III: 1:00 PM – 3:10 PM Category – Novel Agents in Prostate Cancer Moderators: Rhonda Bitting and Purnima Dubey 1:00 – 1:30 Bromodomain Inhibitors in Cancer Irfan Asangani 1:30 – 2:00 Targeting Ubiquitination Signaling for Prostate Cancer Hui-Kuan Lin 2:00 – 2:30 Targeting Neuroendocrine Differentiation in Prostate Cancer Andrew Armstrong 2:30 – 2:40 CDC 25: Potential Target in Prostate Cancer Sittadjody Sivanandane 2:40 – 3:10 Panel Discussion 3:10 – 3:30 BREAK Session IV: 3:30 PM – 5:30 PM Category – Imaging as Biomarker in Prostate Cancer Moderators: Ashok Hemal and Bart Frizzell 3:30 – 4:00 Prostate Imaging, Reporting, and Data System (PIRADS); An Update Rafel Tappouni 4:00 – 4:30 MRI US Fusion in Diagnosis of High Risks Prostate Cancer Pooja Doshi 4:30 – 5:00 Multiparametric Ultrasound in Diagnosis of Prostate Cancer Daniel Rukstalis 5:00 – 5:30 Role of Multiparametric MRI in Active Surveillance for Prostate Cancer Keyanoosh Hosseinzadeh Day 2 – Saturday, April 16, 2016 7:55 – 8:00 AM Welcome back K. C. Balaji Session V: 8:00 – 10:10 AM Category – Biostatistics for Prostate Cancer Moderator: Ronald Davis 08.00 – 08:30 Development and Opportunities for Nomograms in Prostate Cancer Michael Kattan 08:30 – 09:00 Incorporating Probabilities in Surgical Management of Prostate Cancer Ashok Hemal 09:00 – 09:30 Cancer Informatics Platforms for Future Analytics & Research Umit Topaloglu 09.30 – 09:50 Panel Discussion 09.50 – 10.10 BREAK Session VI: 10.10 AM – 12:00 PM Category – Prognostication in Prostate Cancer Moderators: Michael Kattan and Ashok Hemal 10.10 – 10.30 Genetic Predictors of Arachidonic Acid Metabolism in Prostate Cancer. Tao Cui 10:30 – 11.00 Gene Expression Signatures in Management of Prostate Cancer Ronald Davis 11.00 – 11.20 Study of Visceral Metastases; a Marker of Poor Prognosis in Prostate Cancer Michael Rothberg 11.20 – 11.50 Serum PSA as Predictor of Response to Adjuvant Radiotherapy in Prostate Cancer 11.50 - 12.00 Panel discussion and closing remarks BOXED LUNCHES Bart Frizzell