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GIOVANNI FERRARA, MD PhD (Born may 5th 1973) Contact: Dr Giovanni Ferrara Alpvägen 16, Apt 1303 16865 Mariehäll - Stockholm Sweden Country of citizenship: Italy Email address (preferred): [email protected], [email protected] Tel: +46 (0)733 734037 EDUCATION 01/2003 –2/2006 University of Modena and Reggio Emilia – PhD in Experimental Medicine, Modena, Italy – PhD 11/1992 – 10/1998 University “G.d’Annunzio” Chieti – School of Medicine, Chieti, Italy - MD 09/1987 – 07/1992 Gymnasium Liceum “G.B. Vico” – Chieti, Italy PROFESSIONAL TRAINING 11/1998 – 10/2002 University of Modena and Reggio Emilia – Fellowship in Respiratory Medicine, Modena, Italy ACADEMIC QUALIFICATIONS Certified qualification as Associate Professor – Italian Ministry of Education, University and Research – December 2013 Associate Professor – Karolinska Institutet, Stockholm, Sweden – November 2016 WORK EXPERIENCE 11/2016 – to present. Associate Professor in Respiratory Disease, Karolinska Institutet, Stockholm, Sweden. 09/2011 – to present: Senior Consultant (överläkare) in Respiratory Disease at the Dept of Respiratory Medicine and Allergy, Karolinska University Hospital Solna, Stockholm, Sweden. Responsible for one of the 4 sections for inpatients at the Lung Allergi Kliniken, treating most of the respiratory disorders. Responsible for the outpatient clinic for idiopathic pulmonary fibrosis (IPF) and for the Swedish National Registry on IPF. Responsible since September 2014 of the course of respiratory disease for the medical students of the Karolinska Institutet (practical sessions, lectures and evaluation sessions). Main Supervisor of a PhD student and co-supervisor of PhD students at Karolinska Institutet. 04/2007 – 08/2016: assistant professor: teaching activities in the courses of respiratory diseases in the School of Medicine of Perugia (Perugia and Terni’s parallel courses) and in the specialty programs in Occupational Medicine, Geriatrics and Cardiology. University of Perugia, Perugia, Italy 01/2006 – 03/2007: clinical research fellow and fixed term consultant in Respiratory Medicine. University of Modena and Reggio Emilia, Policlinico Hospital, Modena, Italy 01/2003 – 12/2005 PhD and fixed term consultant in Respiratory Medicine: his research activity was focused on immunological tests for the diagnosis of the tuberculosis infection, tuberculosis immunology and in the outcome evaluation of patients with multidrug-resistant tuberculosis. University of Modena and Reggio Emilia, Policlinico Hospital, Modena, Italy. (Supervisors for the PhD: Prof Luca Richeldi and Prof Leonardo M Fabbri). SCIENTIFIC PRODUCTION Publish or Perish statistics: 70 entries from Google Scholar, total number of citations 3357 in 12 years, h-index: 25 (i10-index 32). His paper on The Lancet published in 2006 was cited 567 times. https://scholar.google.it/citations?user=BgaBFgcAAAAJ&hl=sv&cstart=20&pagesize=20 ResearchGate statistics: 70 entries, 2456 citations, h-index 21, RG score 35.67, higher than 92.5% of the ResearchGate members. https://www.researchgate.net/profile/Giovanni_Ferrara2 Karolinska Institutet Bibliometric Analysis Toolkit: in the highest (10th) decentile of all the authors at Karolinska Institutet for number of citations (886) for the years 2011-2015. Please find the list of publications at the end of the CV. SCIENTIFIC AREAS OF INTEREST - - Immunology of the lung, with special focus on infections, interstitial lung diseases and lung cancer; Interstitial lung disease: treatment evaluation and new markers for idiopathic pulmonary fibrosis; immunology of sarcoidosis Tuberculosis and Respiratory infections: new diagnostics; treatment outcomes of MDR/XDR-TB forms; new immunological treatments; infections in the immunocompromised host; Nontuberculous Mycobacteria. Asthma: evidence-based assessment of treatment and of markers of inflammation; EXPERIENCE AT INTERNATIONAL INSTITUTIONS ABROAD 02/2002 – 09/2003 Visiting Research Fellow at the General Clinical Research Center, Chest Service, Bellevue Hospital, NYU (Director William N Rom): His research was focused on the co-expression of immunosuppressive factors (especially CCL18 and IL-10) from infected macrophages. He also worked on the evaluation of IFN-γ via aerosol for the treatment of MDR-TB. Supervisor: Rany Condos, MD, Associate Professor of Medicine. New York University, Bellevue Hospital, New York City, United States From January 1° 2010 to September 4th 2011 he was a visiting researcher in the group of Prof Markus Maeurer in the Microbiology, Cell and Tumor Biology Department of the Karolinska Institutet, Stockholm, Sweden. His research was focused on the use of high-content peptide microarray in the epitope recognition of mycobacterial antigens in course of sarcoidosis and tuberculosis, new immunological treatments for mycobaterial diseases and on the immune response in course of whooping cough infection and vaccination. HONORS/AWARDS 2004 – Japanese Respiratory Travel Award to attend the JRS Congress 2004 in Tokio, Japan 2003 – American Thoracic Society travel award to attend the ATS 2003 Congress in Seattle, WA, USA GRANTS 2009 - Italian Ministry of Health. Co-investigator in the study “Idiopathic pulmonary fibrosis: a national multicenter prospective study validating non invasive biomarkers of disease activity and progression”, principal investigator Prof Luca Richeldi. 2011 – KI Foundation. Grant (period 2011FoBi) for a project on the epitope recognition of mycobaterial antigens from the IgG in the bronchoalveolar lavage fluid of patients with tuberculosis and sarcoidosis. Principal Investigator. 2013 – Swedish Heart-Lung Foundation (Hjärt-lungfonden). Grant for the project ” A comprehensive approach to Idiopathic Pulmonary Fibrosis in Sweden: a national registry to improve clinical management and research”. Principal Investigator. 2013 – KI Foundation. Grant (period 2013FoBi) for a project on the recognition of epitopes from the extracellular matrix of the lung in course of idiopathic pulmonary fibrosis. Principal Investigator. 2013 – Ragna and Paul Nyberg Foundation. Grant to support to activities of the outpatient clinic for idiopathic pulmonary fibrosis at the Karolinska University Hospital Solna, Stockholm, Sweden. 2015 – Swedish Heart-Lung Foundation (Hjärt-lungfonden). Grant for the project ”Improving clinical practice and research on Idiopathic Pulmonary Fibrosis in Sweden: integration of the national registry, the national biobank and new technologies”. 2016 - Ragna and Paul Nyberg Foundation. Grant to support to activities of the outpatient clinic for idiopathic pulmonary fibrosis at the Karolinska University Hospital Solna, Stockholm, Sweden. 2016 – Swedish Heart-Lung Foundation (Hjärt-lungfonden). Grant for the project “Idiopathic Pulmonary Fibrosis in Sweden: validating disease-specific patient reported outcome measures, mortality predictors and implementing the Swedish IPF-Registry and Swedish IPF-Biobank”. Principal Investigator. SCIENTIFIC SOCIETIES 2005 – 2009: member of the American Thoracic Society, MTPI assembly 2005 – Present: member of the International Union Against Tuberculosis and Lung Disease 2004 – Present: member of the European Respiratory Society –Assembly Tuberculosis and Assembly Difuse Parenchymal Lung Diseases. He chaired scientific sessions in the last Congresses of Munich 2006, Stockholm 2007, Berlin 2008, Vienna 2009, Amsterdam 2011, Vienna 2012 and Munich 2014. 2012 – Present: member of the Swedish Lung Disease Association (Svensk Lungmedicinsk Förening, SLMF) Secretary of the European Respiratory Society Tuberculosis Assembly, from September 2009 to September 2012. PEER REVIEW Reviewer for: JAMA – Journal of the American Medical Association, PLoS One, Respiratory Medicine, Clinical Infectious Diseases, European Respiratory Journal, Chest Journal, The International Journal of Tuberculosis and Lung Disease, Tuberculosis, International Journal of Infectious Diseases, The International Journal of Immunopathology and Pharmacology. EDITORIAL ACTIVITIES From January 2011, he is Associate Editor of The International Journal of Tuberculosis and Lung Disease. From January 2012, he is Associate Editor of Italian Reviews of Respiratory Diseases, Official Journal of the Italian Association of Respiratory Disease Specialists. From January 2015 – Reviewer for the European Board for Accreditation in Pnemology – European Respiratory Society From July 2016, he is Associate Editor of Multidisciplinary Respiratory Medicine. SUPERVISION – Ph.D Students Petra Um Bergström, Karolinska Institutet – (co-supervisor, registered 12/2013) REFERENCES Markus Maeurer, MD PhD, Professor of Immunology at the Microbiology, Cell and Tumor Biology Dept., Karolinska Institutet, Nobelsväg 16, SE-17182 Stockolm, Sweden, Phone: +46 (0)8 4572650, email: [email protected] Luca Richeldi, MD, PhD, Professor of Respiratory Disease, University of Southampton, Southampton, UK – Respiratory Centre, University Hospital Southampton, Tremona Road, SO166YD, Southampton, UK. Phone: (+44) 7725 762417– email: [email protected] William N Rom, MD MPH, Professor of Medicine, Dept of Medicine, Director of the Division od Pulmonary, Critical Care and Sleep Medicine, Bellevue Hospita, New York University, 550 First Avenue, New York, NY 10016 - email: [email protected] Stockholm, November 26th, 2016 Giovanni Ferrara, MD PhD _____ ______ LIST OF SCIENTIFIC PUBLICATIONS Sköld CM, Bendstrup E, Myllärniemi M, Gudmundsson G, Sjåheim T, Hilberg O, Altraja A, Kaarteenaho R, Ferrara G. Treatment of idiopathic pulmonary fibrosis: a position paper from a Nordic expert group. J Intern Med 2016 (in press) Ferrara G. Need for combined interventions and operational research to tackle tuberculous meningitis. Int J Tuberc Lung Dis 2016, 20 (11): 1423. Ferrara G, Carlson L, Palm A, Einarsson J, Olivesten C, Sköld M. Idiopathic pulmonary fibrosis (IPF) in Sweden: report from the first year of activity of the Swedish IPF-Registry. Eur Clin Resp J 2016; 3: 31090. Parida SK, Poiret T, Zhenjiang L, Meng Q, Heyckendorf J, Lange C, Ambati AS, Rao MV, Valentini D, Ferrara G, Rangelova E, Dodoo E, Zumla A, Maeurer M. T-Cell Therapy: options for infectious diseases. Clin Infect Dis. 2015 Oct 15;61(suppl 3):S217-S224. Kew KM, Undela K, Kotortsi I, Ferrara G. Macrolides for chronic asthma. Cochrane Database Syst Rev 2015, Sept 15; 9: CD002997 Ronnevi C, Ortiz-Villalon C, Pawlowski J. Ferrara G. Recurrent Respiratory Infections and Unusual Radiology: a woman with Kartagener’s syndrome. BMJ Case Reports. 2015 Sep 9; bcr2015211650. Valentini D, Ferrara G, Advani R, Hallander HO, Maeurer M. Serum reactome induced by Bordetella pertussis infection and Pertussis vaccines: qualitative differences in serum antibody recognition patterns revealed by peptide microarray analysis. BMC Immunology 2015 16(1): 40 Luppi F, Cerri S, Taddei, S, Ferrara G, Cottin V. Acute exacerbations of idiopathic pulmonry fibrosis: a clinical review. Int Emerg Med 2015 10(4): 401-411. O’Grady J, Kik SV, Ferrara G. Extra-pulmonary tuberculosis and Xpert® MB/RIF: all about metaanalyses? Int J Tuberc Lung Dis 2015 19 (3): 254 Bradley M, Nordfors C, Vlastos A, Ferrara G, Ramqvist T, Dalianis T. No association between Birt-Hogg-Dubé syndrome skin fibrofolliculomas and the first 10 described human polyomaviruses or human papillomaviruses. Virology 2014, 468: 244-247. Skrahin A, Ahmed RK, Ferrara G, Rane L, Poiret T, Isaikina Y, Skrahina A, Zumla A, Maeurer M. Open-label Phase I safety trial of autologous mesenchymal stromal cell (MSC) infusion as adjunct treatment in patients with multi- and extensively-drug resistant Tuberculosis. Lancet Respiratory Medicine 2014, 2 (2): 108-122. Kew KM, Karner C, Mindus SM, Ferrara G. Combination formoterol and budesonide as maintenance and reliever therapy versus combination inhaler maintenance for chronic asthma in adults and children. Cochrane Database Syst Rev 2013, Dec 16; 12:CD009019 Molander V, Diakopoulou M, Orre L, Ferrara G. Chronic empyema: importance of preventing complications in the management of pleural effusions BMJ Case Reports 2013: doi:10.1136/bcr2013-200454 Sotgiu G, Centis R, D'Ambrosio L, Spanevello A, Migliori GB, Alffenaar JWC, Anger HA, Caminero JA, Castiglia P, De Lorenzo S, Ferrara G, Koh WJ, Schecter GF, Shim TS, Singla R, Skrahina A, Udwadia ZF, Villar M, Zampogna E, Zellweger JP, Zumla A. Linezolid to treat extensively drug-resistant TB: retrospective data are confirmed by experimental evidence. Eur Respir J 2013 42:1 288-290 Caramori G, Artioli D, Ferrara G, Cazzuffi R, Pasquini C, Libanore M, Guardigni V, Guzzinati I, Contoli M, Rossi R, Rinaldi R, Contini C, Papi A. Severe pneumonia after intravesical BCG instillation in a patient with invasive bladder cancer: case report and literature review. Monaldi Arch Chest Dis 2013 79:1 44-8 Codecasa L, Murgia N, Ferrarese M, Del Mastro M, Repossi AC, Casali L, Besozzi G, Ferrara G, Raviglione MC. Isoniazid Preventive Treatment: Predictors of Adverse Events and Treatment Completion. Int J Tuberc Lung Dis 2013 17:7 903-8 Mindus S, Pawlowski J, Nisell M, Ferrara G. “Intra-abdominal bleeding during treprostinil infusion in a patient with pulmonary arterial hypertension.” BMJ Case Reports 2013 Feb 27;2013. pii: bcr2013008677. doi: 10.1136/bcr-2013-008677. Ferrara G, Zumla A, Maeurer M. Intravenous immunoglobulin (IVIg) for refractory and difficult to treat infections - evidence, molecular mechanisms and rationale. Am J Intern Med 2012 oct; 125(10): 1036.e1-e8. Sotgiu G, Centis R, D'Ambrosio L, Alffenaar J, Anger H, Caminero J, Castiglia P, De Lorenzo S, Ferrara G, Koh W, Schecter G, Shim T, Singla R, Skrahina A, Spanevello A, Udwadia Z, Villar M, Zampogna E, Zellweger J, Zumla A, Migliori GB. Efficacy, safety and tolerability of linezolid containing regimens in treating MDR-TB and XDR-TB: systematic review and meta-analysis. Eur Respir J 2012 Dec 40 (6): 1430-42. Ferrara G, Murray M, Winthrop K, Centis R, Sotgiu G, Migliori GB, Maeurer M, Zumla A. Risk factors associated with pulmonary tuberculosis: smoking, diabetes and anti-TNFα drugs. Curr Opin Pulm Med. 2012 May;18(3):233-40. Pasticci MB, Mazzolla R, Mercuri A, Gamboni G, Bombaci JC, Tiecco C, Rubeca M, Papili R, Pasticci F, Casali L, Ferrara G, Baldelli F. Trends and challenges in Tuberculosis in a mediumsize Southern European setting. Int J Tuberc Lung Dis 2012 may; 16(5): 645-8. Lasserson TJ, Ferrara G, Casali L. Combination fluticasone and salmeterol versus fixed dose combination budesonide and formoterol for chronic asthma in adults and children. Cochrane Database Syst Rev. 2011 Dec 7;12:CD004106. Ferrara G, O'Grady J, Zumla A, Maeurer M. Xpert MTB/RIF test for tuberculosis. Lancet. 2011; 378 (9790):482 McNerney R, Ferrara G, O'Grady J, Maeurer M, Zumla A. Screening of immigrants in UK for latent tuberculosis. Expert Rev Respir Med. 2011; 5(4):483-6. O’Grady J, Maeurer M, Atun R, Abubakar I, Mwaba P, Bates M, Kapata K, Ferrara G, Hoelscher M, Zumla A. Tuberculosis in prisons: anatomy of global neglect. Eur Respir J 2011; 38 (4): 752-754 Ferrara G, Shreemanta Parida, Alimuddin Zumla, Luca Richeldi, Markus Maeurer. A decade of interferon-γ release assays: Quest for the Holy Grail to diagnose latent infection with M. tuberculosis? Am J Resp Crit Care Med 2011;183(12):1732 Miravitlles M, Sotgiu G, Dimopoulos G, Rohde G, Centis R, Ferrara G, Ewig S, Blasi F, Migliori GB. The Best on Infections, update from the 2010 ERS Conference. Eur Respir J 2011; 38(2):4505 Ruhwald M, Dominguez J, Latorre I, Losi M, Richeldi L, Pasticci M, Mazzolla R, Goletti D, Butera O, Bruchfeld J, Gaines H, Gerogianni I, Tuuminen T, Ferrara G, Eugen-Olsen J, Ravn P. A multicentre evaluation of the accuracy of IP-10 for the diagnosis of infection with M. tuberculosis. Tuberculosis 2011; 91(3):260-7 O’Grady J, Hoelscher M, Atun R, Bates M, Mwaba P, Kapata N, Ferrara G, Maeurer M, Zumla A. Tuberculosis in prisons in sub-Saharan Africa e the need for improved health services, surveillance and control. Tuberculosis 2011; 91 (2) 173-178. Diel R, Goletti D, Ferrara G, Bothamley G, Kampmann B, Lange C, Losi M, Roumiana M, Migliori GB, Ruhwald M, Wagner D, Zellweger JP, Huitric E, Sandberg A, Manissero D. Interferon-γ release assays for the diagnosis of M. tuberculosis infection. Eur Respir J. 2011: 37 (1): 88-99; (Epub ahead of print 2010 Oct 28). Miravitlles M, Ferrara G, Lange C, Dimopoulos G, Rohde G, Blasi F, Migliori GB. TB or not TB: update from the ERS Respiratory Infection Assembly 10. Eur Respir J. 2010 Sept 36: 665-670 Ferrara G, Losi M, D’Amico R, Cagarelli R, Pezzi AM, Meacci M, Meccugni B, Marchetti Dori I, Rumpianesi F, Roversi P, Casali L, Fabbri LM, Richeldi L. Interferon-γ-release assays detect recent tuberculosis re-infection in elderly contacts. Int J Immunopathol Pharmacol 2009 Jul-Sept 22: 669-677. Ferrara G, Losi M, Fabbri LM, Migliori GB, Richeldi L, Casali L. Exploring the immune response against Mycobacterium tuberculosis for a better diagnosis of the infection. Arch Immunol Ther Exp 2009 Oct 57: 425-433. Richeldi L, Losi M, D'Amico R, Luppi M, Ferrari A, Mussini C, Codeluppi M, Cocchi S, Prati F, Paci V, Meacci M, Meccugni B, Rumpianesi F, Roversi P, Cerri S, Luppi F, Ferrara G, Latorre I, Gerunda GE, Torelli G, Esposito R, Fabbri LM. Performance of tests for latent tuberculosis in different groups of immunocompromised patients. Chest 2009 Jul 136 (1): 198-204. Sotgiu G, Ferrara G, Matteelli A, Richardson MDA, Centis R, Ruesch-Gerdes S, Toungoussova O, Zellweger JP, Spanevello A, Cirillo D, Lange C, Migliori GB. Epidemiology and clinical management of XDR-TB: a systematic review by TBNET. Eur Respir J 2009 April 33: 871-81. Ferrara G, Bleck B, Richeldi L, Reibman J, Rom WN, Condos R. Mycobacterium tuberculosis induces CCL18 expression in human macrophages. Scand J Immunol 2008 Dec 68: 668-74 Lasserson TJ, Cates CJ, Ferrara G, Casali L. Combination fluticasone and salmeterol versus fixed dose combination budesonide and formoterol for chronic asthma in adults and children. Cochrane Database Syst Rev. 2008 Jul 16;(3):CD004106. Review Richeldi L, Losi M, Cerri S, Casali L, Fabbri LM, Ferrara G. Using ELISpot technology to improve the diagnosis of tuberculosis infection: from the bench to the T-SPOT.TB assay. Expert Review of Respiratory Medicine 2008 April 2, (2): 253-260 Sotgiu G, Arbore AS, Cojocariu V, Piana A, Ferrara G, Cirillo DM, Matteelli A, Castiglia P, Ditiu L, Spanevello A, Zellweger JP, Mihaescu T, Migliori GB. High risk of tuberculosis in health care workers in Romania. Int J Tuberc Lung Dis 2008;12(6):606-11. Migliori GB, Besozzi G, Kliiman K, Lange C, Toungoussova OS, Ferrara G, Cirillo DM, Gori A, Matteelli A, Spanevello A, Codecasa LR, Raviglione MC. Clinical and operational value of the XDR-TB definition. Eur Respir J 2007 October 30 (4): 623-626. Ferrara G, Losi M, D'Amico R, Roversi P, Piro R, Meacci M, Meccugni B, Dori Marchetti I, Andreani A, Bergamini BM, Mussini C, Rumpianesi F, Fabbri LM, Richeldi L. Use in routine clinical practice of two commercial blood tests for diagnosis of infection with Mycobacterium tuberculosis: a prospective study. Lancet. 2006 April 22;367(9519):1328-34. Codecasa LR, Ferrara G, Ferrarese M, Morandi MA, Penati V, Lacchini C, Vaccarino P, Migliori GB. Long term Moxifloxacin in complicated tuberculosis patients with adverse reactions or resistance to first line drugs. Respiratory Medicine 2006 September 100 (9): 1566-1572. Ferrara G, Losi M, Meacci M, Meccugni B, Piro R, Roversi P, Bergamini BM, D’Amico R, Marchigiano P, Rumpianesi F, Fabbri LM, Richeldi L. Routine Hospital Use of a New Commercial Whole Blood Interferon-γ Assay for the Diagnosis of Tuberculosis Infection. Am J Respir Crit Care Med 2005 September 172 (5): 631-635 Richeldi L, Ferrara G, Fabbri L, Lasserson T, Gibson PG. Macrolides for chronic asthma. Cochrane Database Syst Rev 2005 October 19; (4) CD002997 Riccioni G, Di Pietro V, Staniscia T, De Feudis L, Traisci G, Capani F, Ferrara G, Di Ilio E, Di Tano G, D'Orazio N. Community acquired pneumonia in internal medicine: a one-year retrospective study based on pneumonia severity index. Int J Immunopathol Pharmacol. 2005 July-September;18(3):575-586. Ferrara G, Losi M, Franco F, Corbetta L, Fabbri LM, Richeldi L. Macrolides in the treatment of asthma and cystic fibrosis. Respiratory Medicine 2005; 99: 1-10 Ferrara G, Richeldi L, Bugiani M, Cirillo D, Besozzi G, Nutini S, Casali L, Fiorentini F, Codecasa LR, Migliori GB. Management of multidrug-resistant tuberculosis in Italy. Int J Tuber Lung Dis 2005; 9 (5): 507-513 Richeldi L, Davies HR, Ferrara G, Franco F. Corticosteroids for idiophatic pulmonary fibrosis. Cochrane Database Syst Rev 2003; (3): CD003134 Richeldi L, Covi M, Ferrara G, Franco F, Vailati P, Meschiari E, Fabbri LM, Velluti G. Clinical use of Levofloxacin in the long term treatment of drug resistant tuberculosis. Monaldi Arch Chest Dis 2002; 57: 1, 39-43