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GIOVANNI FERRARA, MD PhD
(Born may 5th 1973)
Contact:
Dr Giovanni Ferrara
Alpvägen 16, Apt 1303
16865 Mariehäll - Stockholm
Sweden
Country of citizenship: Italy
Email address (preferred): [email protected], [email protected]
Tel: +46 (0)733 734037
EDUCATION
01/2003 –2/2006 University of Modena and Reggio Emilia – PhD in Experimental Medicine,
Modena, Italy – PhD
11/1992 – 10/1998 University “G.d’Annunzio” Chieti – School of Medicine, Chieti, Italy - MD
09/1987 – 07/1992 Gymnasium Liceum “G.B. Vico” – Chieti, Italy
PROFESSIONAL TRAINING
11/1998 – 10/2002 University of Modena and Reggio Emilia – Fellowship in Respiratory
Medicine, Modena, Italy
ACADEMIC QUALIFICATIONS
Certified qualification as Associate Professor – Italian Ministry of Education, University and
Research – December 2013
Associate Professor – Karolinska Institutet, Stockholm, Sweden – November 2016
WORK EXPERIENCE
11/2016 – to present. Associate Professor in Respiratory Disease, Karolinska Institutet,
Stockholm, Sweden.
09/2011 – to present: Senior Consultant (överläkare) in Respiratory Disease at the Dept of
Respiratory Medicine and Allergy, Karolinska University Hospital Solna, Stockholm, Sweden.
Responsible for one of the 4 sections for inpatients at the Lung Allergi Kliniken, treating most of
the respiratory disorders. Responsible for the outpatient clinic for idiopathic pulmonary fibrosis
(IPF) and for the Swedish National Registry on IPF. Responsible since September 2014 of the
course of respiratory disease for the medical students of the Karolinska Institutet (practical
sessions, lectures and evaluation sessions). Main Supervisor of a PhD student and co-supervisor of
PhD students at Karolinska Institutet.
04/2007 – 08/2016: assistant professor: teaching activities in the courses of respiratory diseases in
the School of Medicine of Perugia (Perugia and Terni’s parallel courses) and in the specialty
programs in Occupational Medicine, Geriatrics and Cardiology. University of Perugia, Perugia,
Italy
01/2006 – 03/2007: clinical research fellow and fixed term consultant in Respiratory Medicine.
University of Modena and Reggio Emilia, Policlinico Hospital, Modena, Italy
01/2003 – 12/2005 PhD and fixed term consultant in Respiratory Medicine: his research activity
was focused on immunological tests for the diagnosis of the tuberculosis infection, tuberculosis
immunology and in the outcome evaluation of patients with multidrug-resistant tuberculosis.
University of Modena and Reggio Emilia, Policlinico Hospital, Modena, Italy. (Supervisors for
the PhD: Prof Luca Richeldi and Prof Leonardo M Fabbri).
SCIENTIFIC PRODUCTION
Publish or Perish statistics: 70 entries from Google Scholar, total number of citations 3357 in 12
years, h-index: 25 (i10-index 32). His paper on The Lancet published in 2006 was cited 567 times.
https://scholar.google.it/citations?user=BgaBFgcAAAAJ&hl=sv&cstart=20&pagesize=20
ResearchGate statistics: 70 entries, 2456 citations, h-index 21, RG score 35.67, higher than 92.5%
of the ResearchGate members.
https://www.researchgate.net/profile/Giovanni_Ferrara2
Karolinska Institutet Bibliometric Analysis Toolkit: in the highest (10th) decentile of all the
authors at Karolinska Institutet for number of citations (886) for the years 2011-2015.
Please find the list of publications at the end of the CV.
SCIENTIFIC AREAS OF INTEREST
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Immunology of the lung, with special focus on infections, interstitial lung diseases and
lung cancer;
Interstitial lung disease: treatment evaluation and new markers for idiopathic pulmonary
fibrosis; immunology of sarcoidosis
Tuberculosis and Respiratory infections: new diagnostics; treatment outcomes of
MDR/XDR-TB forms; new immunological treatments; infections in the
immunocompromised host; Nontuberculous Mycobacteria.
Asthma: evidence-based assessment of treatment and of markers of inflammation;
EXPERIENCE AT INTERNATIONAL INSTITUTIONS ABROAD
02/2002 – 09/2003 Visiting Research Fellow at the General Clinical Research Center, Chest
Service, Bellevue Hospital, NYU (Director William N Rom): His research was focused on the
co-expression of immunosuppressive factors (especially CCL18 and IL-10) from infected
macrophages. He also worked on the evaluation of IFN-γ via aerosol for the treatment of MDR-TB.
Supervisor: Rany Condos, MD, Associate Professor of Medicine. New York University, Bellevue
Hospital, New York City, United States
From January 1° 2010 to September 4th 2011 he was a visiting researcher in the group of Prof
Markus Maeurer in the Microbiology, Cell and Tumor Biology Department of the Karolinska
Institutet, Stockholm, Sweden. His research was focused on the use of high-content peptide
microarray in the epitope recognition of mycobacterial antigens in course of sarcoidosis and
tuberculosis, new immunological treatments for mycobaterial diseases and on the immune response
in course of whooping cough infection and vaccination.
HONORS/AWARDS
2004 – Japanese Respiratory Travel Award to attend the JRS Congress 2004 in Tokio, Japan
2003 – American Thoracic Society travel award to attend the ATS 2003 Congress in Seattle,
WA, USA
GRANTS
2009 - Italian Ministry of Health. Co-investigator in the study “Idiopathic pulmonary fibrosis: a
national multicenter prospective study validating non invasive biomarkers of disease activity and
progression”, principal investigator Prof Luca Richeldi.
2011 – KI Foundation. Grant (period 2011FoBi) for a project on the epitope recognition of
mycobaterial antigens from the IgG in the bronchoalveolar lavage fluid of patients with tuberculosis
and sarcoidosis. Principal Investigator.
2013 – Swedish Heart-Lung Foundation (Hjärt-lungfonden). Grant for the project ” A
comprehensive approach to Idiopathic Pulmonary Fibrosis in Sweden: a national registry to
improve clinical management and research”. Principal Investigator.
2013 – KI Foundation. Grant (period 2013FoBi) for a project on the recognition of epitopes from
the extracellular matrix of the lung in course of idiopathic pulmonary fibrosis. Principal
Investigator.
2013 – Ragna and Paul Nyberg Foundation. Grant to support to activities of the outpatient clinic
for idiopathic pulmonary fibrosis at the Karolinska University Hospital Solna, Stockholm, Sweden.
2015 – Swedish Heart-Lung Foundation (Hjärt-lungfonden). Grant for the project ”Improving
clinical practice and research on Idiopathic Pulmonary Fibrosis in Sweden: integration of the
national registry, the national biobank and new technologies”.
2016 - Ragna and Paul Nyberg Foundation. Grant to support to activities of the outpatient clinic
for idiopathic pulmonary fibrosis at the Karolinska University Hospital Solna, Stockholm, Sweden.
2016 – Swedish Heart-Lung Foundation (Hjärt-lungfonden). Grant for the project “Idiopathic
Pulmonary Fibrosis in Sweden: validating disease-specific patient reported outcome measures,
mortality predictors and implementing the Swedish IPF-Registry and Swedish IPF-Biobank”.
Principal Investigator.
SCIENTIFIC SOCIETIES
2005 – 2009: member of the American Thoracic Society, MTPI assembly
2005 – Present: member of the International Union Against Tuberculosis and Lung Disease
2004 – Present: member of the European Respiratory Society –Assembly Tuberculosis and
Assembly Difuse Parenchymal Lung Diseases. He chaired scientific sessions in the last Congresses
of Munich 2006, Stockholm 2007, Berlin 2008, Vienna 2009, Amsterdam 2011, Vienna 2012 and
Munich 2014.
2012 – Present: member of the Swedish Lung Disease Association (Svensk Lungmedicinsk
Förening, SLMF)
Secretary of the European Respiratory Society Tuberculosis Assembly, from September 2009 to
September 2012.
PEER REVIEW
Reviewer for: JAMA – Journal of the American Medical Association, PLoS One, Respiratory
Medicine, Clinical Infectious Diseases, European Respiratory Journal, Chest Journal, The
International Journal of Tuberculosis and Lung Disease, Tuberculosis, International Journal of
Infectious Diseases, The International Journal of Immunopathology and Pharmacology.
EDITORIAL ACTIVITIES
From January 2011, he is Associate Editor of The International Journal of Tuberculosis and
Lung Disease.
From January 2012, he is Associate Editor of Italian Reviews of Respiratory Diseases, Official
Journal of the Italian Association of Respiratory Disease Specialists.
From January 2015 – Reviewer for the European Board for Accreditation in Pnemology –
European Respiratory Society
From July 2016, he is Associate Editor of Multidisciplinary Respiratory Medicine.
SUPERVISION – Ph.D Students
Petra Um Bergström, Karolinska Institutet – (co-supervisor, registered 12/2013)
REFERENCES
Markus Maeurer, MD PhD, Professor of Immunology at the Microbiology, Cell and Tumor
Biology Dept., Karolinska Institutet, Nobelsväg 16, SE-17182 Stockolm, Sweden, Phone: +46 (0)8
4572650, email: [email protected]
Luca Richeldi, MD, PhD, Professor of Respiratory Disease, University of Southampton,
Southampton, UK – Respiratory Centre, University Hospital Southampton, Tremona Road,
SO166YD, Southampton, UK. Phone: (+44) 7725 762417– email: [email protected]
William N Rom, MD MPH, Professor of Medicine, Dept of Medicine, Director of the Division od
Pulmonary, Critical Care and Sleep Medicine, Bellevue Hospita, New York University, 550 First
Avenue, New York, NY 10016 - email: [email protected]
Stockholm, November 26th, 2016
Giovanni Ferrara, MD PhD
_____
______
LIST OF SCIENTIFIC PUBLICATIONS
Sköld CM, Bendstrup E, Myllärniemi M, Gudmundsson G, Sjåheim T, Hilberg O, Altraja A,
Kaarteenaho R, Ferrara G. Treatment of idiopathic pulmonary fibrosis: a position paper from a
Nordic expert group. J Intern Med 2016 (in press)
Ferrara G. Need for combined interventions and operational research to tackle tuberculous
meningitis. Int J Tuberc Lung Dis 2016, 20 (11): 1423.
Ferrara G, Carlson L, Palm A, Einarsson J, Olivesten C, Sköld M. Idiopathic pulmonary fibrosis
(IPF) in Sweden: report from the first year of activity of the Swedish IPF-Registry. Eur Clin Resp J
2016; 3: 31090.
Parida SK, Poiret T, Zhenjiang L, Meng Q, Heyckendorf J, Lange C, Ambati AS, Rao MV, Valentini
D, Ferrara G, Rangelova E, Dodoo E, Zumla A, Maeurer M. T-Cell Therapy: options for infectious
diseases. Clin Infect Dis. 2015 Oct 15;61(suppl 3):S217-S224.
Kew KM, Undela K, Kotortsi I, Ferrara G. Macrolides for chronic asthma. Cochrane Database
Syst Rev 2015, Sept 15; 9: CD002997
Ronnevi C, Ortiz-Villalon C, Pawlowski J. Ferrara G. Recurrent Respiratory Infections and
Unusual Radiology: a woman with Kartagener’s syndrome. BMJ Case Reports. 2015 Sep 9;
bcr2015211650.
Valentini D, Ferrara G, Advani R, Hallander HO, Maeurer M. Serum reactome induced by
Bordetella pertussis infection and Pertussis vaccines: qualitative differences in serum antibody
recognition patterns revealed by peptide microarray analysis. BMC Immunology 2015 16(1): 40
Luppi F, Cerri S, Taddei, S, Ferrara G, Cottin V. Acute exacerbations of idiopathic pulmonry
fibrosis: a clinical review. Int Emerg Med 2015 10(4): 401-411.
O’Grady J, Kik SV, Ferrara G. Extra-pulmonary tuberculosis and Xpert® MB/RIF: all about metaanalyses? Int J Tuberc Lung Dis 2015 19 (3): 254
Bradley M, Nordfors C, Vlastos A, Ferrara G, Ramqvist T, Dalianis T. No association between
Birt-Hogg-Dubé syndrome skin fibrofolliculomas and the first 10 described human polyomaviruses
or human papillomaviruses. Virology 2014, 468: 244-247.
Skrahin A, Ahmed RK, Ferrara G, Rane L, Poiret T, Isaikina Y, Skrahina A, Zumla A, Maeurer M.
Open-label Phase I safety trial of autologous mesenchymal stromal cell (MSC) infusion as adjunct
treatment in patients with multi- and extensively-drug resistant Tuberculosis. Lancet Respiratory
Medicine 2014, 2 (2): 108-122.
Kew KM, Karner C, Mindus SM, Ferrara G. Combination formoterol and budesonide as
maintenance and reliever therapy versus combination inhaler maintenance for chronic asthma in
adults and children. Cochrane Database Syst Rev 2013, Dec 16; 12:CD009019
Molander V, Diakopoulou M, Orre L, Ferrara G. Chronic empyema: importance of preventing
complications in the management of pleural effusions BMJ Case Reports 2013: doi:10.1136/bcr2013-200454
Sotgiu G, Centis R, D'Ambrosio L, Spanevello A, Migliori GB, Alffenaar JWC, Anger HA,
Caminero JA, Castiglia P, De Lorenzo S, Ferrara G, Koh WJ, Schecter GF, Shim TS, Singla R,
Skrahina A, Udwadia ZF, Villar M, Zampogna E, Zellweger JP, Zumla A. Linezolid to treat
extensively drug-resistant TB: retrospective data are confirmed by experimental evidence. Eur
Respir J 2013 42:1 288-290
Caramori G, Artioli D, Ferrara G, Cazzuffi R, Pasquini C, Libanore M, Guardigni V, Guzzinati I,
Contoli M, Rossi R, Rinaldi R, Contini C, Papi A. Severe pneumonia after intravesical BCG
instillation in a patient with invasive bladder cancer: case report and literature review. Monaldi
Arch Chest Dis 2013 79:1 44-8
Codecasa L, Murgia N, Ferrarese M, Del Mastro M, Repossi AC, Casali L, Besozzi G, Ferrara G,
Raviglione MC. Isoniazid Preventive Treatment: Predictors of Adverse Events and Treatment
Completion. Int J Tuberc Lung Dis 2013 17:7 903-8
Mindus S, Pawlowski J, Nisell M, Ferrara G. “Intra-abdominal bleeding during treprostinil infusion
in a patient with pulmonary arterial hypertension.” BMJ Case Reports 2013 Feb 27;2013. pii:
bcr2013008677. doi: 10.1136/bcr-2013-008677.
Ferrara G, Zumla A, Maeurer M. Intravenous immunoglobulin (IVIg) for refractory and difficult to
treat infections - evidence, molecular mechanisms and rationale. Am J Intern Med 2012 oct;
125(10): 1036.e1-e8.
Sotgiu G, Centis R, D'Ambrosio L, Alffenaar J, Anger H, Caminero J, Castiglia P, De Lorenzo S,
Ferrara G, Koh W, Schecter G, Shim T, Singla R, Skrahina A, Spanevello A, Udwadia Z, Villar M,
Zampogna E, Zellweger J, Zumla A, Migliori GB. Efficacy, safety and tolerability of linezolid
containing regimens in treating MDR-TB and XDR-TB: systematic review and meta-analysis. Eur
Respir J 2012 Dec 40 (6): 1430-42.
Ferrara G, Murray M, Winthrop K, Centis R, Sotgiu G, Migliori GB, Maeurer M, Zumla A. Risk
factors associated with pulmonary tuberculosis: smoking, diabetes and anti-TNFα drugs. Curr Opin
Pulm Med. 2012 May;18(3):233-40.
Pasticci MB, Mazzolla R, Mercuri A, Gamboni G, Bombaci JC, Tiecco C, Rubeca M, Papili R,
Pasticci F, Casali L, Ferrara G, Baldelli F. Trends and challenges in Tuberculosis in a mediumsize Southern European setting. Int J Tuberc Lung Dis 2012 may; 16(5): 645-8.
Lasserson TJ, Ferrara G, Casali L. Combination fluticasone and salmeterol versus fixed dose
combination budesonide and formoterol for chronic asthma in adults and children. Cochrane
Database Syst Rev. 2011 Dec 7;12:CD004106.
Ferrara G, O'Grady J, Zumla A, Maeurer M. Xpert MTB/RIF test for tuberculosis. Lancet. 2011;
378 (9790):482
McNerney R, Ferrara G, O'Grady J, Maeurer M, Zumla A. Screening of immigrants in UK for
latent tuberculosis. Expert Rev Respir Med. 2011; 5(4):483-6.
O’Grady J, Maeurer M, Atun R, Abubakar I, Mwaba P, Bates M, Kapata K, Ferrara G, Hoelscher
M, Zumla A. Tuberculosis in prisons: anatomy of global neglect. Eur Respir J 2011; 38 (4): 752-754
Ferrara G, Shreemanta Parida, Alimuddin Zumla, Luca Richeldi, Markus Maeurer. A decade of
interferon-γ release assays: Quest for the Holy Grail to diagnose latent infection with M.
tuberculosis? Am J Resp Crit Care Med 2011;183(12):1732
Miravitlles M, Sotgiu G, Dimopoulos G, Rohde G, Centis R, Ferrara G, Ewig S, Blasi F, Migliori
GB. The Best on Infections, update from the 2010 ERS Conference. Eur Respir J 2011; 38(2):4505
Ruhwald M, Dominguez J, Latorre I, Losi M, Richeldi L, Pasticci M, Mazzolla R, Goletti D, Butera
O, Bruchfeld J, Gaines H, Gerogianni I, Tuuminen T, Ferrara G, Eugen-Olsen J, Ravn P. A
multicentre evaluation of the accuracy of IP-10 for the diagnosis of infection with M. tuberculosis.
Tuberculosis 2011; 91(3):260-7
O’Grady J, Hoelscher M, Atun R, Bates M, Mwaba P, Kapata N, Ferrara G, Maeurer M, Zumla A.
Tuberculosis in prisons in sub-Saharan Africa e the need for improved health services, surveillance
and control. Tuberculosis 2011; 91 (2) 173-178.
Diel R, Goletti D, Ferrara G, Bothamley G, Kampmann B, Lange C, Losi M, Roumiana M, Migliori
GB, Ruhwald M, Wagner D, Zellweger JP, Huitric E, Sandberg A, Manissero D. Interferon-γ
release assays for the diagnosis of M. tuberculosis infection. Eur Respir J. 2011: 37 (1): 88-99;
(Epub ahead of print 2010 Oct 28).
Miravitlles M, Ferrara G, Lange C, Dimopoulos G, Rohde G, Blasi F, Migliori GB. TB or not TB:
update from the ERS Respiratory Infection Assembly 10. Eur Respir J. 2010 Sept 36: 665-670
Ferrara G, Losi M, D’Amico R, Cagarelli R, Pezzi AM, Meacci M, Meccugni B, Marchetti Dori I,
Rumpianesi F, Roversi P, Casali L, Fabbri LM, Richeldi L. Interferon-γ-release assays detect recent
tuberculosis re-infection in elderly contacts. Int J Immunopathol Pharmacol 2009 Jul-Sept 22:
669-677.
Ferrara G, Losi M, Fabbri LM, Migliori GB, Richeldi L, Casali L. Exploring the immune response
against Mycobacterium tuberculosis for a better diagnosis of the infection. Arch Immunol Ther
Exp 2009 Oct 57: 425-433.
Richeldi L, Losi M, D'Amico R, Luppi M, Ferrari A, Mussini C, Codeluppi M, Cocchi S, Prati F,
Paci V, Meacci M, Meccugni B, Rumpianesi F, Roversi P, Cerri S, Luppi F, Ferrara G, Latorre I,
Gerunda GE, Torelli G, Esposito R, Fabbri LM. Performance of tests for latent tuberculosis in
different groups of immunocompromised patients. Chest 2009 Jul 136 (1): 198-204.
Sotgiu G, Ferrara G, Matteelli A, Richardson MDA, Centis R, Ruesch-Gerdes S, Toungoussova O,
Zellweger JP, Spanevello A, Cirillo D, Lange C, Migliori GB. Epidemiology and clinical
management of XDR-TB: a systematic review by TBNET. Eur Respir J 2009 April 33: 871-81.
Ferrara G, Bleck B, Richeldi L, Reibman J, Rom WN, Condos R. Mycobacterium tuberculosis
induces CCL18 expression in human macrophages. Scand J Immunol 2008 Dec 68: 668-74
Lasserson TJ, Cates CJ, Ferrara G, Casali L. Combination fluticasone and salmeterol versus fixed
dose combination budesonide and formoterol for chronic asthma in adults and children.
Cochrane Database Syst Rev. 2008 Jul 16;(3):CD004106. Review
Richeldi L, Losi M, Cerri S, Casali L, Fabbri LM, Ferrara G. Using ELISpot technology to
improve the diagnosis of tuberculosis infection: from the bench to the T-SPOT.TB assay. Expert
Review of Respiratory Medicine 2008 April 2, (2): 253-260
Sotgiu G, Arbore AS, Cojocariu V, Piana A, Ferrara G, Cirillo DM, Matteelli A, Castiglia P, Ditiu
L, Spanevello A, Zellweger JP, Mihaescu T, Migliori GB. High risk of tuberculosis in health care
workers in Romania. Int J Tuberc Lung Dis 2008;12(6):606-11.
Migliori GB, Besozzi G, Kliiman K, Lange C, Toungoussova OS, Ferrara G, Cirillo DM, Gori A,
Matteelli A, Spanevello A, Codecasa LR, Raviglione MC. Clinical and operational value of the
XDR-TB definition. Eur Respir J 2007 October 30 (4): 623-626.
Ferrara G, Losi M, D'Amico R, Roversi P, Piro R, Meacci M, Meccugni B, Dori Marchetti I,
Andreani A, Bergamini BM, Mussini C, Rumpianesi F, Fabbri LM, Richeldi L. Use in routine
clinical practice of two commercial blood tests for diagnosis of infection with Mycobacterium
tuberculosis: a prospective study. Lancet. 2006 April 22;367(9519):1328-34.
Codecasa LR, Ferrara G, Ferrarese M, Morandi MA, Penati V, Lacchini C, Vaccarino P, Migliori
GB. Long term Moxifloxacin in complicated tuberculosis patients with adverse reactions or
resistance to first line drugs. Respiratory Medicine 2006 September 100 (9): 1566-1572.
Ferrara G, Losi M, Meacci M, Meccugni B, Piro R, Roversi P, Bergamini BM, D’Amico R,
Marchigiano P, Rumpianesi F, Fabbri LM, Richeldi L. Routine Hospital Use of a New Commercial
Whole Blood Interferon-γ Assay for the Diagnosis of Tuberculosis Infection. Am J Respir Crit
Care Med 2005 September 172 (5): 631-635
Richeldi L, Ferrara G, Fabbri L, Lasserson T, Gibson PG. Macrolides for chronic asthma.
Cochrane Database Syst Rev 2005 October 19; (4) CD002997
Riccioni G, Di Pietro V, Staniscia T, De Feudis L, Traisci G, Capani F, Ferrara G, Di Ilio E, Di
Tano G, D'Orazio N. Community acquired pneumonia in internal medicine: a one-year
retrospective study based on pneumonia severity index. Int J Immunopathol Pharmacol. 2005
July-September;18(3):575-586.
Ferrara G, Losi M, Franco F, Corbetta L, Fabbri LM, Richeldi L. Macrolides in the treatment of
asthma and cystic fibrosis. Respiratory Medicine 2005; 99: 1-10
Ferrara G, Richeldi L, Bugiani M, Cirillo D, Besozzi G, Nutini S, Casali L, Fiorentini F, Codecasa
LR, Migliori GB. Management of multidrug-resistant tuberculosis in Italy. Int J Tuber Lung Dis
2005; 9 (5): 507-513
Richeldi L, Davies HR, Ferrara G, Franco F. Corticosteroids for idiophatic pulmonary fibrosis.
Cochrane Database Syst Rev 2003; (3): CD003134
Richeldi L, Covi M, Ferrara G, Franco F, Vailati P, Meschiari E, Fabbri LM, Velluti G. Clinical
use of Levofloxacin in the long term treatment of drug resistant tuberculosis. Monaldi Arch Chest
Dis 2002; 57: 1, 39-43