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12/9/2013 Craig E. Smith, MD, MS, CTropMed, FACP, FIDSA Medical Director, Infectious Diseases University Hospital, Augusta, GA 1 12/9/2013 Antimicrobial stewardship is defined as a rational, systematic approach to the use of antimicrobial agents in order to achieve optimal outcomes. “Optimal outcomes” include those of the patient (achievement of cure, avoidance of toxicity and other adverse effects) and of the larger population (avoidance of emergence or propagation of antimicrobial resistance). Dellit T.H., et al. Clinical Infectious Diseases (2007) 44:159-77 Monitor antimicrobial prescribing practices at a health care institution with intervention as needed. Results in : Improve outcomes for individual patients Optimize treatment of infectious processes Minimize risk of complications of therapy Reduce length of stay Improve outcomes for the larger population Reduce antimicrobial selection pressure to limit antimicrobial resistance Reduce unnecessary pharmacy expenditures 2 12/9/2013 Core group of team members: • Infectious Diseases Physician or other interested Physician • Clinical pharmacist with infectious diseases training • Clinical microbiologist • Infection control professional Meets weekly for small for rapid cycle changes • Require the support and collaboration of hospital administration, medical staff leadership, and local providers as well as IT support. 3 12/9/2013 4 12/9/2013 Segmented regression analysis of interrupted time series data. MacDougall C , and Polk R E Clin. Microbiol. Rev. 2005;18:638-656 Key to Success of Program Engagement: “To involve one-self or become occupied; to participate fully and deeply” Respected for leadership and communication skills and clinical role modeling Excellent practice outcomes Passionate/enthusiastic to achieve high quality performance indicators and process improvements Tireless 5 12/9/2013 Willing to devote time, energy and activism to make changes Seeks to understand current processes, data and outcomes Brings quality improvement skills, vision and innovation to the table Operational leader in designing, implementing and measuring improvement Secure Medical Staff buy-in and engage administrative and senior leadership support: ◦ Acceptance of the collaborative CQI project ◦ Resources ◦ Willingness to act upon recommendations Advocate and reinforce purposes, goals, advantages of participation and expected results: ◦ Financial incentives; awards, esp. “PFP” ◦ Success with quality audits ◦ Decrease length of stay 6 12/9/2013 MD Elements of Honor Roll Phase 1- Engagement: 1. Letter of Commitment from Leadership 2. Antibiotic Stewardship Team 3. Educational Event Phase 2- Implementation 4. Antibiotic Stewardship Programs 5. Measurement of Impact of Program 7 12/9/2013 Georgia Honor Roll for Antibiotic Stewardship The Georgia HAI Advisory Committee and Antibiotic Stewardship Subcommittee have developed an honor roll program to recognize facilities engaged in stewardship. The requirements of the Honor Roll support the stewardship principles and tools provided today. William Osler 1849-1919 8