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Figure S1A
Figures S1A & S1B: Forest plots showing hazard ratio (HR) for overall survival (OS; A) and progression-free survival (PFS; B) comparing subgroups of left-sided and rightsided colorectal cancer. Effect of PTL on outcome is considered for each treatment arm of the studies. Caption: n = number of patients; CI = confidence interval;
PTL = primary tumour location; RC = right-sided colorectal cancer; LC = left-sided colorectal cancer; FE = fixed-effect model; RE = random-effect model;
Cap = capecitabine; FOL = folinic acid; F = fluorouracil; L = leucovorin; I(RI) = irinotecan; OX = oxaliplatin; bev = bevacizumab; cet = cetuximab
Figure S1B
Figure S2A
Figures S2A and S2B: Results of univariate meta-regressions for overall survival (OS; A) and
progression-free survival (PFS; B). Caption: Left-sided colorectal cancer is taken as reference.
HR = hazard ratio; CI = confidence interval; bev = bevacizumab; cet = cetuximab; chemo,
chemotherapy
Figure S2B
Figure S3A
Figures S3A & S3B: Funnel plots of logarithmic hazard ratio for overall survival (OS; A) and
progression-free survival (PFS; B) drawn from the random-effects model of the meta-analysis in
Fig. 1. Caption: Each study is represented by one dot; the vertical line represents the pooled
effect estimate. OS = overall survival; PFS = progression-free survival; HR = hazard ratio
Figure S3B
Figure S4
Figure S4: Interaction test between primary tumour location (PTL) and treatment benefit from anti-EGFR
antibody. Displayed are the results of univariate meta-regressions for overall survival (OS), progression-free
survival (PFS) and overall response rate (ORR) when tumour side is used as predictor. Comparison of hazard
ratio (HR) and odds ratio (OR) according to PTL is displayed.
Figure S5
Figure S5: Interaction test between primary tumour location (PTL) and treatment effects of anti-EGFR or anti-VEGF-based
treatment. Displayed are the results of univariate meta-regressions for overall survival (OS), progression-free survival (PFS)
and overall response rate (ORR) when tumour side is used as predictor. Comparison of hazard ratio (HR) and odds ratio
(OR) according to PTL is displayed.