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Chest Radiology Plain Film and CT- Beyond the Basics John W. Renner, M.S., M.D. Clinical Professor of Radiology UCSD Medical Center Brendan Kidder, M.S. IV UCSD School of Medicine Chest Radiology Goals • Review the basics of Chest Imaging • Examine the modalities of the Chest “Plain Film” and Computed Tomography • Review basic disease entities and their imaging evaluation • Allow Hospitalists to better understand “How to talk to a radiologist in a hospital setting if you must!” Chest Radiology Normal Radiographic Anatomy • • • • • • Normal frontal and lateral views Cross-sectional anatomy Symmetry and asymmetry Interfaces, lines and junction stripes Chest compartments Densities Normal Chest Pre-Vascular Space Anterior Junction Line Right Paratracheal Stripe Carina Basal Segmental Anatomy Main Pulmonary Artery Aortic Valve Inferior Pulmonary Veins Left Coronary Artery Right Coronary Artery Secondary pulmonary lobule Webb, R : Radiology 2006 Chest Radiology Patterns of Disease • • • • • • • Honeycombing Cystic lesions Nodules Ground-glass opacities Mosaic pattern Tree-in-bud Interlobular septal thickening Honeycombing Chest X-Ray .com Centrilobular Emphysema Webb, R. Radiology 2006 Centrilobular Emphysema Centrilobular Emphysema Webb, R. Radiology 2006 Centrilobular Nodules Webb, R. Radiology 2006 Sarcoidosis Chest X-Ray. com Sarcoidosis Webb, R. Radiology 2006 Hypersensitivity Pneumonitis Webb, R. : Radiology 2006 Ground-Glass Opacities Chest X-Ray. com Pulmonary Edema Bronchopneumonia Mosaic Perfusion Chest X-Ray. com Mosaic Perfusion Mosaic Perfusion Transplant Lung Transplant Lung Tree-in-Bud Tree-in-Bud Webb, R. : Radiology 2006 Interlobular Septal Thickening Webb, R. Radiology 2006 Interlobular Septal Thickening Webb, R. Radiology 2006 Lymphangitic Carcinomatosis Webb, R. Radiology 2006 Lymphangitic Carcinomatosis Bronchiectasis Chest X-Ray. com Air Trapping Chest X-Ray. com Head Cheese Sign Webb, R. : Radiology 2006 Crazy Paving Pattern Idiopathic Pulmonary Hemosiderosis Idiopathic Pulmonary Hemosiderosis Idiopathic Pulmonary Hemosiderosis Aspergilomas Bronchogenic Cyst Interstitial Pulmonary Fibrosis Interstitial Pulmonary Fibrosis Interstitial Pulmonary Fibrosis Neurofibromatosis Neurofibromatosis Neurofibromatosis Chest Radiography • Congenital Pulmonary Abnormalities – Tracheal bronchus – Pulmonary arteriovenous malformation – Partial anomalous pulmonary venous return – Bronchopulmonary sequestration – Congenital lobar emphysema and cysts Right Upper Lobe Bronchus Tracheal Bronchus Hypogenetic Lung Pulmonary Sequestration Pulmonary Sequestration Thrombosed Aneurysm Pulmonary Sequestration Pulmonary Artery Sling Pulmonary Artery Sling Hilar Lymphadenopathy Pneumocystis Pneumonia Pneumocystis Pneumonia Pneumocystis Pneumonia Pulmonary Tuberculosis Chest Radiology Critical Care Radiography • Pulmonary Embolism – Chest radiograph • Normal vs. abnormal – – – – Westermark’s sign Enlargement of the central pulmonary arteries Hampton’s hump-pulmonary infarction Atelectasis, consolidation and elevation of the ispilateral hemidiaphragm – Pleural effusion Chest Radiography Critical Care Radiography • Pulmonary Thromboembolism-Catheter Angiogram – – – – – – Pulmonary angiography-former “gold standard” Invasive with known morbidity-mortality High specificity—approaching 100% Right heart catheterization-useful data Negative exam excludes the diagnosis Allows for treatment— • Thrombolytics • IVC filter placement Chest Radiology Critical Care Radiography • Pulmonary Thromboembolism-CTA – High sensitivity (>90%), specificity (>95%) – CTA limited in sub-segmental arteries – Evaluation of upstream findings-right heart strain – CT findings • Intra-luminal filling defect or • Vessel cutoff • Mosaic perfusion Chest Radiology Critical Care Radiography • Pulmonary Thromboembolism-CTA – CT Pulmonary Angiogram • Requires MDCT, helical scan • Requires iodinated contrast—high concentration of iodine, non-ionic or iso-osmolar contrast agents • Requires apnea during scan • Requires normal renal function • Relatively high radiation dose! Massive Thromboembolism Massive Thromboembolism Massive Thromboembolism Pulmonary Thromboembolism Chest Radiology • Chronic Thromboembolism – Organizing thromboemboli – Adherent clots to vessel wall – Lack of recanalization of a vessel – Webs, bands – Abrupt caliber change – Pulmonary arterial hypertension – Mosaic perfusion Type A Aortic Dissection Primary Pulmonary Hypertension Chest Radiology • Pulmonary Arterial Hypertension – Dilation of central pulmonary arteries – Rapid tapering of peripheral pulmonary arteries – Dilation of right interlobar pulmonary artery to > 18 mm on PA chest view – Dilation of left pulmonary artery to > 18 mm on lateral chest view – Dilation of RA, RV Primary Pulmonary Arterial Hypertension Primary Pulmonary Artery Hypertension Tricuspid Regurgitation Chest Radiology Idiopathic Interstitial Pneumonias • • • • Idiopathic Pulmonary Fibrosis-IPF Non-specific Interstitial Pneumonia-NSIP Cryptogenic Organizing Pneumonia-COP Respiratory Bronchiolitis-associated Interstitial Lung Disease-RB-ILD • Desquamative Interstitial Pneumonia • Lymphoid Interstitial Pneumonia-LIP • Acute Interstitial Pneumonia-AIP Idiopathic Pulmonary Fibrosis Idiopathic Pulmonary Fibrosis Non-specific Interstitial Pneumonia IPF vs. NSIP Cryptogenic Organizing Pneumonia Respiratory Bronchiolitis-ILD Desquamative Interstitial Pneumonia Lymphoid Interstitial Pneumonia Organizing Pneumonia ILS plus GGO Chest Radiology Critical Care Radiography • CXR may be done on a daily basis • Evaluate “life-support” lines, tubes catheters, devices, monitoring equipment • Evaluate changes in cardiopulmonary status • Determine why a patient has undergone “clinical deterioration”— – Hypoxia – Hypotension – Sepsis Chest Radiology Critical Care Radiography • Pulmonary Edema – Hydrostatic – Increased capillary permeability – Diffuse alveolar damage –(DAD) – Differential diagnosis • • • • Atelectasis Pneumonia Aspiration Pulmonary embolism and hemorrhage Chest Radiology Critical Care Radiography • Hydrostatic Pulmonary Edema – Pulmonary venous hypertension and vascular redistribution – Interstitial pulmonary edema – Alveolar pulmonary edema – Cardiomegaly – Pleural effusion – Vascular pedicle Chest Radiology Critical Care Radiography • Pulmonary Edema – Interstitial pulmonary edema – Kerley A, B and C lines • • • • • • Interlobular septal thickening Subpleural edema along fissures,pleura Peribronchial cuffing Perihilar haze Interstitial veiling Ground-glass opacities Interstitial Pulmonary Edema Chest Radiology Critical Care Radiography • Alveolar Edema – Air-space consolidation – Acinar or air-space ill-defined nodules – Peri-hilar or “batwing” distribution – Peripheral sparing – Rapid clearance with theraphy – Occasionally a clinical lag in onset and clearance Chest Radiology Critical Care Radiography • Increased Permeability Edema or ARDS and DAD – Alveolar-capillary leak, normal left atrial pressure • Multiple etiologies • Occurs in stages – – – – Latent period Air-space consolidation Homogeneous confluence and air bronchogram Decreased lung volumes and pulmonary compliance compliance – Slow clearance – Organizing chronic changes--fibrosis Chest Radiology Critical Care Radiography • Barotrauma – Mechanical ventilation and increased airway resistance, high ventilatory pressures, CPAP and others – Extra-alveolar air • • • • Pulmonary interstitial emphysema Pneumomediastinum Pneumothorax Subcutaneous emphysema Chest Radiology Cardiac • Cardiac CT – Calcium scoring – Coronary artery angiography-CTA – Congenital Heart Disease – Anatomical applications – Triple rule-out LAD Stenosis CT Coronary Angiography LAD Stenosis Calcium LAD 3D Workstation CTA Coronary Artery Right Coronary Artery LAD-Soft Plaque Multiplanar Reconstruction Anomalous Left Coronary Artery Consensus • A negative test may be consistent with a low risk of a cardiovascular event in the next two to five years • A high calcium score may be consistent with a moderate to high risk of a cardiovascular event within the next two to five years Chest Radiology • Airways Disease – Trachea – Bronchiectasis-cylindrical, varicose, cystic – Cystic Fibrosis – ABPA and asthma – Chronic bronchitis – Bronchiolitis Chest Radiology • Emphysema – Centrilobular emphysema – Panlobular emphysema – Paraseptal emphysema – Bullous emphysema – Saber-sheath trachea Chest Radiology Pneumonia • Lobar pneumonia – Peripheral opacity to homogenous consolidation • Bronchopneumonia – Airway mucosa to alveoli • Interstitial pneumonia – Reticular opacities to confluent infection • Lung abscess – Cavitation Chest Radiology Tuberculosis • Primary tuberculosis • Post-primary tuberculosis • HIV-associated tuberculosis Chest Radiology Lung Cancer • Early Detection – National Lung Cancer Screening Trial • Chest x-ray vs. low-dose CT – International Early Lung Cancer Action Project—I-ELCAP • Low-dose screening CT • 92% survival rate, stage I • NEJM 355:1763-1771, Oct. 26, 2006 Chest Radiography Cardiac • Cardiac MRI – Myocardial function – Myocardial viability – Valvular heart disease – Systolic heart failure – Diastolic heart failure – Myocarditis – Pericardial diseases Chest Radiology • Thank you John W. Renner, M.S., M.D. Clinical Professor of Radiology Department of Radiology UCSD Medical Center San Diego, California