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Curriculum Vitae
Shaomei Wang, M.D., PhD.
Cedars-Sinai Regenerative Medicine Institute
Department of Biomedical Science
8700 Beverly Blvd, AHSP, 8th Floor, A8107
Telephone: (310) 248- 7970
Facsimile: (310) 248-8555
Email: [email protected]
Citizenship: U.S. citizen
Education
MD
Masters
PhD
Jinzhou Medical College, PR China, 1984
Chinese Medical University, PR China 1987
University of Sheffield, UK 1997
Postdoctoral Training
1997-2000
Laboratory of Dr Raymond Lund, Institute of Ophthalmology, UCL,
London, UK.
Professional Experience
2012-present Associate professor, Department of Biomedical Sciences and
Regenerative Medicine Institute, Cedars-Sinai Medical Center,
Los Angeles, CA, USA
2006–2011
Assistant Professor, Casey Eye Institute, OHSU, Portland, USA
2005-2006
Assistant Professor, Moran Eye Center, Utah, USA
2001-2004
Lab specialists, Moran Eye Center, Utah, USA.
1997-2000
Post-doctoral fellow, Institute of Ophthalmology, UCL, UK
1994 -1997 Research assistant (PhD student), University of Sheffield, UK.
1991-1993
Visiting Scientist, University of Sheffield, UK
1987-1991
Lecturer, Jinzhou Medical College, PR China.
Professional memberships
Association for Research in Vision and Ophthalmology
Society for Neuroscience
CSMC professional activities
RMI retreat committee 2012
The second Cedars-Sinai Regenerative Medicine scientific symposium,
Co-Chair for retinal section.
Journal Referee
Editor: Transplantation & technology and research
Editorial Board member: Journal of organ biology
Investigative Ophthalmology and Visual Science
Cell research
Experimental Eye Research
Vision Research
Current Eye Research
Expert Reviews
Xenotransplantation
Plus One
Stem cell international
Awards
2014
First place Faculty Elevator Pitch RMI Retreat
1991-1992
British Council and Chinese government award (visiting scholar to
University of Sheffield, UK)
Graduate studentship, Jinzhou Medical college, PR China
1984-1987
Current Grant Support
1R01EY020488
NIH/NEI
Wang (PI, 50%) $250,000/year
9/1/2011-8/31/2016
Development of non-invasive cell-based therapy for retinal degeneration and
associated vascular pathology.
The overall objective of this research proposal is to preserve vision and limit
vascular pathology using non-invasive MSC therapy in rodent models for retinal
degeneration. The MSCs have been widely used in both regenerative and
degenerative medicine. The proposed research will be critical in determining
whether systemic administration of MSCs offers a realistic likelihood of
translation to the clinic for the treatment of retinal degeneration and ocular
vascular pathology.
VRPD 11259003
Wang (PI. 5%) $12,500/year
09/01/2012-08/31/2014
Department of Army
Non-invasive cell based therapy for traumatic optic neuropathy
The main objective of this study is to protect retinal ganglion cells after traumatic
optic nerve injury with non-invasive cell based therapy.
CIRM (UCI sub-award)
Lu (PI)
$284,910/year
08/2013-07/2016
Retinal progenitor cells for treatment of retinitis pigmentosa
The first year study is to conduct prove of concept study to examine the efficacy
of human retinal progenitor cells in rescuing vision after injecting into the rodent
model for retinitis pigmentosa.
Co-PI, 20%
Janssen Research & Development, LLC
Wang (PI. 5%)
$166,444
2012-2014
Janssen Research & Development, LLC
Wang (PI, 5%)
$187,125
2013-2015
This is to study stem cells isolated from umbilical tissue have advantages
including non ethical issue, less immune-related problem, differentiating into
several cell types. The main purpose of this project is to examine whether
umbilical derived stem cells can preserve vision after subretinal injection into a
rat model for retinal degeneration. We will evaluate the efficacy by testing visual
function and examining photoreceptor preservation. If positive results come out
from this study, it will provide great potential to use these stem cells in clinics.
CS-RMI startup fund
(PI. 10%) $300,000/year
6/1/2011-5/31/2014
Preclinical studies on the efficacy, long-term survival of donor cells, mechanism
of action and immunological responses after cell-based therapy.
Knight Templar Eye Foundation (Tsai, PI)
Career start-up grant
Role: Preceptor
$60,000/year
7/1/2014-6/31/2016
This is to study ‘Mechanisms of action of human iPSC-derived neural progenitor
cells on treating orphan degenerative retinal disease.
Fight For sight (Bakondi, PI)
$20,000
8/1/2014-7/31/2015
The title of this fellowship is “Does The Extracellular Matrix (ECM) Secreted By
Neural Progenitor Cells (NPCs) Contribute to Visual Preservation Following
Subretinal Delivery In A Rodent Model Of Retinitis Pigmentosa?”
Role: Mentor
*************************
Past funding:
Foundation Fighting Blindness- Wynn-Gund
Gamm (PI)
$85,000/year
06/01/08-05/31/13
Customized IPS cell therapy for recessive monogenetic retinal degenerative
disease.
The objective of this grant is to examine the efficacy of IPS cells derived from
recessive monogenetic retinal degenerative disease in rodent models. Our
module will provide fundamental information regarding how these IPS cells
behave in the degenerative retina.
Role: Subcontract-PI
Lincy Foundation
Gamm (PI)
$178,000
02/01/2009-07/31/2012
Utilization of human neural progenitor cells (hNPC) for retinal cell rescue in agerelated macular degeneration.
The project is to examine efficacy and safety of human neural progenitor cells
created under GMP condition in rodent model for retinal degeneration and nonhuman primate. The outcome goal is to use the hNPC to treat retinal
degeneration at clinic.
Role: module-PI
Research Projects and Research Interest
Our laboratory has a long history of applying cell-based therapy for retinal
degeneration. We have explored the efficacy of a range of different cell types
including (i) cells to replace defective retinal pigment epithelial (RPE) cells such
as human embryonic stem cell-derived RPE cells, (ii) cells that appear to function
by releasing growth factors such as peripheral nerve ensheathing cells (Schwann
cells) or cells genetically modified to release growth factors, and (iv) cells with
multiple functions such as stem and progenitor cells. Our main research
interests: apply stem cell therapy to treat retinal degenerative diseases;
Understanding age-related pathological changes in the eyes from Ageing models
and Alzheimer’s diseases.
Invited talks
International
1994
Jinzhou Medical College, PR China
2006
Jinzhou Medical College, PR China
National
2011, January. FFB annual meeting, Madison, Wisconsin
2012, April.
FFB annual meeting, Madison, Wisconsin
2013. January. FFB annual meeting, Madision, Wisconsin
Local/regional
2014. Regenerative Medicine Institute, CA
2013, Regenerative Medicine Institute, CA
2012 Regenerative Medicine Institute, CA
2011 University of California, San Diego
2010 University of California, Irvine, Orange city
2010 Cedars-Sinai Regenerative Medicine Institute, Los Angeles, CA.
2010 Retinal group, Casey Eye Institute, OHSU, Portland, OR
2009 Uveitis group, Casey Eye Institute, Portland, OR
Teaching
Postgraduates: 2012-present: neuron activities; retinal degenerative diseases
and treatments
High school students: 2012-present: Cell based therapy for retinal degeneration
Student Instructional Activities
Doctoral candidates:
Toby Holmes: 2001-05-research adviser
Elsa Raibon: 2002-04-research adviser
Melissa Jones: 2013-present-supervisor
Postdoctoral:
Yuchun Tsai: 2012-present-research adviser
Muhammad U Jawad: 2011-2012-research adviser
Chunyu Tian: 2008-09-research adviser
Trevor McGill: 2007-2011-research adviser
Benjamin Bakondi: 2013-present-research adviser
Run Tian: 2014-present-research adviser
Graduates:
Nick Bischoff: 2002-2004- research adviser/supervisor
Ethan Chancellor: 2003-2005- research adviser/supervisor
Jean Hunter: 2004-2006-research adviser/supervisor
Xiaoying Cheng: 2002-2005-research adviser/supervisor
Jie Duan: 2006-2011-research adviser/supervisor
Lin Shen: 2011-present-research adviser/supervisor
Yuan Zhang: 2008-2010-research adviser/supervisor
Benjamin Cottam: 2006-20010-research adviser/supervisor
Undergraduates
Claudia Tan: 2013
Sasha Park: 2014
High school students:
Julia Li-2008
Kemy Lin-2009
Sabrina Levy-2009
Shiny Zhang-2009
Manerva Chen-2010
Mary Bessell: 2013-present
Research Papers (peer-reviewed)
1. Telford S, Wang S, Redgrave P (1996). Analysis of nociceptive neurons in the
rat superior colliculus using c-fos immunohistochemistry. J. Comp. Neurol.
375:601-617.
2. Wang S, and Redgrave P (1997). Microinjections of muscimol into lateral
superior colliculus disrupt orienting and oral movements in the formalin model of
pain. Neuroscience 81: 967-988.
3. Kwan A, Wang S, Lund RD (1999). Reconstruction of photoreceptor layer in
rodent model. Exp Neurol 159 (1): 21-33.
4. Wang S, Villegas-Perez MP, Vidal-Sanz M, Lund RD (2000). Vascular
consequence of the photoreceptor loss in the rd mouse and the effects on retinal
ganglion cell axons. Invest Ophthal Vis Sci. 41:537-545.
5. Wang S, Wang H, Niemi-Junkola U, Westby GWM, McHaffie JG, Stein BE,
Redgrave P(2000). Parallel analyses of nociceptive neurons in rat superior
colliculus using c-fos immunohistochemistry and electr-ophysiology under
different conditions of anesthesia. J Comp Neurol. 425, 599-615.
6. Sauvé Y, Girman SV, Wang S, Lawrence JM, Lund RD (2001). Progressive
visual dysfunction in the RCS rat and the long-term preventive effect of RPE cell
transplantation. Neuroscience 103:51-63.
7. Lund RD, Adamson P, Sauvé Y, Keegan DJ, Girman SJ, Wang S, Winton H,
Kanuga N, Kwan ASL, Beauchene L, Zerbib A, Hetherington L, Couraud P,
Coffey P, Greenwood J (2001). Subretinal Transplantation of Genetically
Modified Human Cell Lines Attenuates Loss of Visual Function in Dystrophic
Rats. Proc. Natl. Acad. Sci. USA. 98(17): 9942-7.
8. McHaffie JG, Wang S, Walton N, Stein BE, Redgrave P (2002). Covariant
maturation of nocifensive oral behaviour and c-fos expression in rat superior
colliculus. Neuroscience.109: 597-607.
9. Sauvé Y, Girman SV, Wang S, Keegan D, Lund RD (2002). Preservation of
visual sensitivity in RCS rats following subretinal retinal pigment epithelium cell
transplantation. Neuroscience, 114(2): 389-401.
10. Coffey PJ, Girman SV, Wang S, Keegan DJ, Adamson P, Greenwood J,
Lund RD (2002). Long-term preservation of cortically mediated visual function in
dystrophic RCS rats by transplantation of immortalised retinal pigment epithelial
cells. Nat Neurosci. 5:53-56.
11. Wang S, Villegas-Perez MP, Lawrence JM, Vidal-Sanz M, Lund RD (2003).
Evolving neurovascular relationships in the RCS rat. Curr Eye Res. 27(3): 18396.
12. Girman SV, Wang S, Lund RD (2003). Cortical visual functions can be
preserved by subretinal RPE cell grafting in RCS rat. Vis Res. 43(17): 1817-27.
13. Lu B, Coffey PJ, Wang S, Ferrari R, Lund RD (2004). Abnormal c-fos-like
Immunoreactivity in the Superior Colliculus and Other Subcortical Visual Centers
of Pigmented Royal College of Surgeons Rats. J Comp Neurol. 472(1): 100-12.
14. Cuenca N, Pinilla I, Sauvé Y, Lu B, Wang S, Lund RD (2004). Regressive
and reactive changes in the connectivity patterns of rod and cone pathways of
P23H transgenic rat retina. Neuroscience, 127(2): 301-17.
15. McGill TJ, Lund RD, Douglas RM, Wang S, Lu B, Prusky GT (2004).
Preservation of vision following cell-based therapies in a model of retinal
degenerative disease. Vis Res. 44(22): 2559-66.
16. Girman SV, Wang S, Lund RD (2005). Time course of deterioration of rod
and cone function in RCS rat and the effect of subretinal cell grafting: a light-and
dark-adaptation study. Vis Res. 45: 343-54.
17. Wang S, Lu B, Wood P, Lund R (2005). Distribution over time of ARPE-19
and Schwann Cells after Grafting to the Subretinal Space in RCS Rats and the
Relation to Photoreceptor Rescue. Invest Ophthalmol Vis Res 46, 2552-60.
18. Wang S, Lu B, Lund R (2005). Morphological Changes in the RCS Retina
during Photoreceptor Degeneration and after Cell-based Therapy. J Comp
Neurol. 491(4): 400-417.
19. Raymond D. Lund, Shaomei Wang, Irina Klimanskaya, Toby Holmes,
Rebecca Kelsey, Bin Lu, Sergej Girman, N. Bischoff, Yves Sauvé, Robert Lanza
(2006). Human Embryonic Stem Cell-Derived Cells Rescue Visual Function In
Dystrophic RCS Rat. Cloning and Stem Cells. 8(3): 189-99.
20. Lund RD, S. Wang, B. Lu, S. Girman, T. Holmes, Y. Sauvé, D, J.Messina, I.
R. Harris, T. J. Kihm, A. M.Harmon, Chin Feng-Yi, A. Gosiewska, S. K. Mistry
(2007). Cells isolated from umbilical cord tissue rescuephotoreceptors and visual
functions in a rodent model of retinal disease. Stem cells. 25: 602-11.
21. McGill TJ, Lund RD, Douglas RM, Wang S, Lu B, Silver, BD, Secretan, MR,
Arthur, JN and Prusky GT (2007). Syngeneic Schwann cell transplantation
preserves vision in RCS rat without immunosuppression. Invest Opthalmol Vis
Res 48, 1906-12.
22. Gamm DM, S.Wang, B.Lu, S.Girman , T.Holmes, N.Bischoff, R.Shearer,
Y.Sauve, Capowski E, C.N. Svendsen and RD Lund (2007). Protection functions
by human neural progenitors in a rat model of retinal disease. PLOS-ONE, 2:
e338.
23. Pinilla I, Cuenca N, Sauve Y, Wang S, Lund RD (2007). Preservation of outer
retina and its synaptic connectivity following subretinal injections of human RPE
cells in the Royal College of Surgeons rat. Exp eye Res. 85:381-92.
24. Wang S, Lu B, Girman S, Holmes T, Bischoff N, Lund RD (2008).
Morphological and functional rescue in RCS rats after RPE cell line
transplantation at a later stage of degeneration. Invest Ophthalmol Vis Sci.
49(1):416-21.
25. Wang S, Girman S, Lu B, Bischoff N, Holmes T, Shearer R, Wright L,
Svendsen CV, Gamm DM, R Lund (2008). Long Term Vision Rescue by Human
Neural Progenitors in Rat Model of Photoreceptor Degeneration. Invest
Ophthalmol Vis Sci. 49 (7): 3201-6.
26. Francis* PJ, Wang* S, Zhang Y, Brown A,Hwang T, McFarland T, Jeffrey,
B.G, Lu B, Wright, L, Appukuttan B, Wilson, D. J, Stout, J.T, Neuringer M,
Gamm* DM, Lund* RD (2009). Subretinal Transplantation of forebrain Progenitor
Cells in Non-human Primates: Survival and Intact Retinal function. Invest
Ophthalmol Vis Sci. 50 (7): 3425-31.
27. Bin Lu*, Christopher Malcuit*, Shaomei Wang*, Sergej Girman, Peter
Francis, Linda Lemieux, Robert Lanza, Raymond Lund (2009). Long-term Safety
and Function of RPE from Human Embryonic Stem Cells in Preclinical Models of
Macular Degeneration. Stem Cells.27 (9): 2126-35.
28. Lu B, Wang S, Francis PJ, Li T, Gamm DM, Capowski EE and RD Lund
(2009). Cell Transplantation to Arrest Early Changes in an USH 2A Animal
Model. Invest Ophthalmol Vis Sci. Dec.3 (ePub).
29. Wang S*, Lu B, Girman S, Duan J, McFarland T, Zhang QS, Grompe M,
Adamus G, Appukuttan B and R Lund (2010).Non-invasive stem cell therapy in a
rat model for retinal degeneration and vascular pathology. PLoS ONE
5(2):e9200.
30. Lu B, S Wang*, S. Girman, T McGill, V Ragaglia, R Lund (2010). Human
adult bone marrow-derived somatic cells rescue vision in a rodent model of
retinal degeneration. Exp Eye Res. 91(3): 449-55.
31. Adamus Grazyna, Wang Shaomei, Kyger Madision, Worley Aneta, Lu Bin and
Burrows Greg (2012). Systemic immunotherapy delays photoreceptor cell loss and
prevents vascular pathology in RCS rats. Molecular vision. 18:2323-37.
32. McGill TJ, Cottam B, Lu B, Wang S, Girman S, Tian C, Huhn SL, Lund RD and
Capela A (2012). Transplantation of human central nervous system system stem
cells-neuroprotection in retinal degeneration. Eur J Neurosci. 35 (3):468-77.
33. Jonathan G. Swoboda, Jimmy Elliott, Vishal Deshmukh, Lorenzo de
Lichtervelde, Weijun Shen, Matthew S. Tremblay, Charles Y. Cho, Bin Lu, Sergej
Girman, Shaomei Wang, Peter G. Schultz. Small molecule mediated proliferation
of primary retinal pigment epithelial cells. ACS Chem Biol. 2013, May 8
34. Nicolás Cuenca1, Laura Fernández-Sánchez1, Trevor J. McGill2, Bin Lu3,
Shaomei Wang3, Raymond Lund4, Stephen Huhn5, Alexandra Capela.
Phagocytosis of photoreceptor outer segments by transplanted human neural
stem cells as a neuroprotective mechanism in retinal degeneration. Invest
Ophthalmol Vis Sci. 2013, Sep 17.
35. Bin Lu, Catherine W Morgans, Sergey Girman, Raymond Lund and Shaomei
Wang Retinal Morphological and Functional Changes in an Animal Model of
Retinitis Pigmentosa. Vis Neurosci, 2013: 1-13.
36. Bin Lu, Catherine W. Morgans, Sergey Girman, Jing Luo, Jiagang Zhao,
Hongjun Du, SiokLam Lim, Sheng Ding, Clive Svendsen, Kang Zhang and
Shaomei Wang. Neural Stem Cells Derived by Small Molecules Preserve Vision.
Transl Vis Sci Technol. 2013: 2.
37. Tsai YC, Lu B, Ljubimov AV, Girman S, Ross-Cisneros FN, Sadun AA,
Svendsen CN, Cohen RM, Wang S. Ocular changes in TgF344-AD rat model of
Alzheimer’s Disease. Invest Ophthalmol Vis Sci. 2014: 55: 1523-534.
38.
Lu B, Lin Y, Tsai Y, Girman S, Adamus G, Jones MK, Shelley B,
Svendsen CN, Wang S. A Subsequent Human Neural Progenitor Transplant into
the Degenerate Retina Does Not Compromise Initial Graft Survival or
Therapeutic Efficacy. Trans Vis Sci Technol 2015;4:1
Book Chapters
1. Redgrave P, Telford S, Wang SM, McHaffie JG, Stein BE (1996) Functional
anatomy of nociceptive neurons in rat superior colliculus. Prog in Brain Res (eds.
G. Holstege, R. Bandler, and C. B. Saper) 107, 403-415.
2. Raymond D. Lund and Shaomei Wang (2006). Cell-Based Therapies to
Restrict the Progress of Photoreceptor Degeneration. Book: Retinal
Degenerations, editors: Tombran-Tink and Barnstable. 620-2; Humana Press;
Chapter 17: 317-342.
Peper submitted:
YuChun Tsai; Bin Lu; Sergey Girman; Benjamin Bakondi; Melissa K. Jones;
Anais Sahabian; Dhruv Sareen; Clive Svendsen; Shaomei Wang. Human iPSCderived neural progenitors preserve vision in an AMD-like model. Stem cells
(submitted revision).
Sergey Girman and Shaome Wang. Responses of concentric retinal ganglion
cells convey information about stimulus shape. J of Vision 2015
Abstract (past two years)
Abstracts
Sergey Girman and Shaomei Wang. Earliest manifestation of MERTK mutation:
Abnormal ERG recovery after brief exposure to moderate light in very young
RCS rats 2013, ARVO, D0290.
Bin Lu; YuChun Tsai; Grazyna Adamus; Sergey Girman; Lin Shen; David M.
Gamm; Catherine W. Morgans; Brandon Shelley; Clive Svendsen; Shaomei
Wang. Effect of Repeated Delivery of Neural Progenitors on Vision Preservation
in RCS Rats 2013, ARVO, A0030.
Shaomei Wang; YuChun Tsai; Sergey Girman; Lin Shen; Catherine W. Morgans;
Grazyna Adamus; Weidong Xiong; Vaithi Arumugaswami; Clive Svendsen; Bin
Lu. Manipulating MSC Homing To Enhance Its Efficacy in Preserving
Vision 2013, ARVO, B0194.
YuChun Tsai; Bin Lu; Sergey Girman; Clive Svendsen; Robert M. Cohen;
Shaomei Wang. Ocular changes in a rat model of Alzheimer’s Disease 2013,
ARVO, D0232.
Jing Yang, Geoffrey P. Lewis; Bin Lu; Nikolay Turovets; Gabriel Luna; Sergey
Girman; Gerhard Bauer; Steven K. Fisher; Shaomei Wang; Henry J. Klassen.
Translational development of human retinal progenitor cells for treatment of
retinitis pigmentosa 2013, ARVO, A0106.
Benjamin Bakondi; YuChun Tsai; Bin Lu; Sergey Girman; Lin Shen; Melissa K.
Jones; Shaomei Wang. Is Mesenchymal Stem Cell Homing To The Injured
Retina Required For Visual Preservation In The RCS Rat? 2014, ARVO, A0133.
YuChun Tsai; Bin Lu; Sergey Girman; Benjamin Bakondi; Melissa K. Jones;
Anais Sahabian; Dhruv Sareen; Clive Svendsen; Shaomei Wang. Human
iPSC-derived neural progenitor cells preserve vision in a rat retinal degeneration
model.2014, ARVO, D0037.
Melissa K. Jones; Bin Lu; Sergey Girman; YuChun Tsai; Benjamin Bakondi;
Brandon Shelley; Alexander V. Ljubimov; Clive Svendsen; Shaomei Wang. In
vivo study of neural progenitors after injection into a retinal degeneration rodent
model. 2014, ARVO, C0172.
Shaomei Wang; YuChun Tsai; Benjamin Bakondi; Sergey Girman; Lin Shen; Bin
Lu. Systemic administration of MSCs preserves RGC survival after optic nerve
crush. 2014. ARVO, B0139.