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An ionic bond is a type of chemical bond that involves a metal and a nonmetal ion (or polyatomic ions such as ammonium) through electrostatic attraction. In short, it is a bond formed by the attraction between two oppositely charged ions. The metal donates one or more electrons, forming a positively charged ion or cation with a stable electron configuration. These electrons then enter the non metal, causing it to form a negatively charged ion or anion which also has a stable electron configuration. The electrostatic attraction between the oppositely charged ions causes them to come together and form a bond. For example, in sodium chloride when sodium (Na) and chlorine (Cl) are combined, the sodium atoms each lose an electron, forming a cation (Na+), and the chlorine atoms each gain an electron to form an anion (Cl−). These ions are then attracted to each other in a 1:1 ratio to form sodium chloride. Pure ionic bonding is not known to exist. All ionic compounds have a degree of covalent bonding. The larger the difference in electronegativity between two atoms, the more ionic the bond. Ionic compounds conduct electricity when molten or in solution. They generally have a high melting point and tend to be soluble in water. In an ionic bond, the atoms are bound by attraction of opposite ions, whereas, in a covalent bond, atoms are bound by sharing electrons. In reality, purely ionic bonds do not (and cannot) exist, as this would require an infinitely large electronegativity difference, and complete charge transfer is unfavorable from the viewpoint of raising the electronic kinetic energy. All ionic bonds have some covalent character. For example, Na–Cl and Mg–O bonds have a few percent covalency, while Si–O bonds are usually ~50% ionic and ~50% covalent. Predominantly covalent bonds with partial ionic character are called polar covalent. Ions in crystal lattices of purely ionic compounds are spherical; however, if the positive ion is small and/or highly charged, it will distort the electron cloud of the negative ion. This polarization of the negative ion leads to a build-up of extra charge density between the two nuclei, i.e., to partial covalency. Larger negative ions are more easily polarized, but the effect is usually only important when positive ions with charges of 3+ (e.g., Al3+) are involved. However, 2+ ions (Be2+) or even 1+ (Li+) show some polarizing power because their sizes are so small. Ionic Bonds Mainly occur through attractions between opposite charges. For example, between protonated amino (on salbutamol or quaternary ammonium (eg acetylcholine), and the dissociated carboxylic acid group. Similarly, the dissociated carboxylic acid group on the drug can bind with amino groups on the receptor. This type of bonds are very strong, and varies with distances. so it could act over large Cation-π interactions can also be classified as ionic bonding. This occurs when a cation, eg acetylcholine, interacts with the negative π bonds on an aromatic group of the receptor. Ion-dipole and dipole-dipole bonds have similar interactions, but are more complicated and are weaker than ionic bonds.