Download (TGF-b) signaling - The Prostate Net

Dr Shafiq Khan Lab
Transforming Growth Factor beta (TGF-b) signaling
•How TGF-b promotes tumor progression
•The role of the different TGF-b isoforms
Dr Jaideep Chaudhary Lab
Inhibitors of Differentiation (Id)
•Promotes tumor progression
Viruses causing prostate cancer
•Pathway of action
Dr Valerie Odero-Marah Lab
Snail transcription factor
•Promotes tumor progression via reactive oxygen species
•Promotes metastasis to bone
Dr. Cimona V. Hinton Lab
PTEN and CXCR4
•Studying how loss of tumor suppressors permits metastasis enhancing genes.
PTEN usually lost early in cancer progression
CXCR4
associated
with
metastasis
Dr Godwin Ananaba Lab
Role of Sterols in prostate cancer
•How high cholesterol and low phytosterol can promote prostate cancer
•Using cyclodextran compounds as a delivery system
Sources of Funding
 National Institute of Health (NIH): RCMI,
P20
 National Cancer Institute (NCI): RO1
 Department of Defense (DOD): Idea, New
Investigator, Pca Training Grant
 Georgia Research Alliance (GRA):
equipment and personnel
Publications and Presentations
 May 2009-April 2010: 11 journal articles
 50 presentations in national meetings
Research Facilities






Molecular Biology
Cell Biology
Structural Biology
Histology
Bioinformatics and Biostatistics
Analytical
Collaborative Center for Cancer
Genomics (CCGC)
 Collaborative effort between Clark Atlanta
University and Ovarian Cancer Institute at
Georgia Tech
 Gene expression analysis of individual
patients
Prostate Cancer Tissue Bank
 Collaboration between Saint Joseph’s
hospital and Georgia Tech
 Intend to acquire prostate cancer patient
samples for analysis at the Genomics
center
 Intend to establish a prostate cancer
tissue bank