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Exercise In Chronic Heart Failure Aynsley Cowie Senior I Physiotherapist, Ayr Hospital PhD Student, Glasgow Caledonian University Overview • • • • • Exercise intolerance in CHF Effects of exercise Evidence for exercise training PhD Practical implications & advice to patients Exercise Intolerance in Chronic Heart Failure Why is exercise tolerance reduced? Exercise Intolerance peakVO2, due to: – cardiac output response – nutritive blood flow to skeletal muscles – skeletal muscle abnormalities • • • • %type I fibres mitochondria capillary density muscle fibre size Exercise Intolerance Metabolic abnormalities – early dependence on anaerobic metabolism – muscle wasting AEROBIC METABOLISM ANAEROBIC METABOLISM OXYGEN IN CELL OXYGEN ABSENT GLUCOSE GLUCOSE ENERGY ENERGY PYRUVATE PYRUVATE ENERGY CO2 & H2O NO ENERGY LACTATE Exercise Intolerance Early respiratory muscle de-oxygenation & fatigue – – – – excessive ventilatory effort inefficient ventilation V/Q mismatch higher breathing frequency Acidity of blood Early activation of muscle ergoreflex Health-related Quality of Life Proposed Effects of Exercise in Chronic Heart Failure Effects of Exercise 15-20% peakVO2, due to: – cardiac output response • modest in heart rate & stroke volume • diastolic filling at peak exercise – changes to skeletal muscle • nutritive blood flow to skeletal muscles • O2 extraction • mitochondria Effects of Exercise Improved metabolic functioning – reliance on anaerobic metabolism ventilatory efficiency neuro-endocrine activity sympathetic nervous system activity Effects of Exercise Therefore: • exercise tolerance • symptom severity • improved NYHA class • improved quality of life ……….without: • in central haemodynamics • unfavourable LV remodelling But, no clear evidence regarding effects on prognosis Evidence to Support Exercise Training in Chronic Heart Failure Evidence • Patients historically advised to restrict physical activity to reduce circulatory demands • Coats et al (1990): first RCT to conclude that exercise actually improves fitness, symptoms and quality of life of those with CHF Evidence • NICE 5 (2003): Both aerobic & resistive exercise will improve symptoms, exercise performance & quality of life without deleterious effects on central haemodynamics • SIGN 57 (2002): Patients with chronic heart failure should considered for comprehensive cardiac rehabilitation if they have limiting symptoms • European Society of Cardiology (2001): Exercise training…..can increase exercise capacity in compensated stable chronic heart failure patients Literature Search Search Criteria: • published in 2000 or more recently • published in English • evaluating a specific programme of training • including exercise capacity &/or quality of life outcomes 45 studies found (August 2006) Literature Search 7 studies were non-controlled, most conducted out with UK Samples: • Generally small but widely ranging (6-200), mean n=44 • Mean age ~60y • Women tended to be excluded • Most included those of NYHA II & III Location: • Most evaluated hospital-based programmes • Home programmes as effective as hospital programmes • None compared home versus hospital programmes Literature Search Mode: • Most trials incorporated cycling in training • Many very equipment-orientated • Very few evaluated resistance training • Those using home walking demonstrated least improvement in exercise capacity Literature Search Frequency: • 3 x week or more is required for benefit Length: • Should be at least 8 weeks • None examine longer programmes / if effects are sustained Duration: • Conditioning of <30 minutes = least effect on exercise capacity Intensity: • 60-70% peakVO2 for best effect on exercise capacity Literature Search Conclusion: • Small samples, excluding elderly and women • Home walking programmes were least effective • None compared effects of home- & hospital-based exercise • Training mode was equipment-orientated • Most evidence advocates training at least 3 x week for at least 30 minutes (plus warm-up and cool-down) • Best outcomes achieved if intensity set to 60-70% peakVO2 • Few evaluated resistance training A Study Comparing Effects of Home and Hospital-based Exercise on Exercise Capacity and Quality of Life of Patients with Chronic Heart Failure Aims: To determine effects of hospital- versus home-based exercise training (versus “usual care”) on exercise capacity and quality of life of patients with CHF To determine patients’ perceptions of the effects of homeversus hospital-based exercise training Design Pre-test measurement of exercise capacity & quality of life Randomisation Hospital-based exercise Focus groups to examine perceptions of effects of training Home-based exercise Control group Post--test measurement of exercise capacity & quality of life Sample n=60 (45) Recruitment from Heart Failure Nurse Liaison Service & Cardiology clinics Inclusion Criteria: • Diagnosis of LVSD by echo • Sufficiently clinically stable for exercise (3-4 weeks) • Willing to participate Exclusion Criteria: • Other life threatening illness • Unable to participate due to major cognitive impairment Contraindications Absolute • Progressive worsening of exercise tolerance / SOB over past 3-5 days • Significant ischaemia at low work rates • Uncontrolled diabetes • Acute systemic illness or fever • Recent embolism / thromboembolism • Active pericarditis / myocarditis • Moderate to severe aortic stenosis • Regurgitant valvular heart disease requiring surgery • MI within past 3 weeks • New onset AF (European Society of Cardiology, 2001) Contraindications Relative • >1.8kg in body mass over previous 1-3 days • Concurrent dobutamine therapy • Decrease in SBP with exercise • NYHA class IV • Complex ventricular arrhythmias at rest, or with exertion • Supine resting heart rate >100bpm • Pre-existing co-morbidities • Poorly controlled AF (European Society of Cardiology, 2001) Exercise Interventions Hospital-based: • Physiotherapist led classes • • • • Home-based: Prescribed by physiotherapist DVD & home exercise booklet / diary & Heart rate monitor 3 follow-up phone calls from physiotherapist Both: • 8 weeks duration, 2 x week, 1 hour per session • Each session: 15 minute warm-up, 30 minute functional aerobic circuit exercises (interval training), 10 minute cool-down Control: • General physical activity advice Outcomes Exercise Capacity: • Shuttle / 6 minute walk depending on pilot results Quality of Life: • Literature suggests generic & disease-specific questionnaire • Minnesota Living with Heart Failure & SF-36 most valid & reproducible Perceptions of Effects of Exercise: • Home- and hospital-exercisers kept separate • 2-3 group of each (6-7 participants per group) • Previous exercise experience, expectations, perceived effects of exercise, barriers / facilitators, future exercise ambitions Methodology n=60 participants recruited from Heart Failure Nursing Service & Cardiology Clinics Pre-test measurement of exercise capacity (by shuttle/6 minute walk) & quality of life (Minnesota & SF-36) Randomisation 8 weeks Hospital-based exercise Control Home-based exercise Post-test measurement of exercise capacity (by shuttle/6 minute walk) & quality of life (Minnesota & SF-36) 2 or 3 focus groups to examine perceptions of effects of training 2 or 3 focus groups to examine perceptions of effects of training Plan…... •Final amendments to be made for ethics •Data collection planned for Spring 2007-Spring 2008 Practical Implications for Patients Attending Rehabilitation Advice for Patients Patient Evaluation • Referrals from clinics, cardiologists / other consultants, GPs or other health professionals • Good recruitment protocol with agreed criteria & contraindications • Heart failure must have been stable for around 3-4 weeks • Patients of NYHA I to III are eligible - ?some stable class IVs • No lower limit to ejection fraction • Don’t wait for optimisation of medications • Any arrhythmias should be as well controlled as possible Patient Assessment Subjective: • Gauge “normal” heart failure symptoms • Threshold for ICDs • Status of up-titration • Are they checking their weight regularly? Objective: • Weight if not self-monitoring • BP and resting heart rate • ?recent ECG • Measurement of functional capacity • Measurement of quality of life Exercise Session • Warm-up: 5-15 minutes • Conditioning: 10-30 minutes aerobic exercise alternated with active recovery • Cool-down: 5-10 minutes • • • • • Seated exercises where appropriate Should be tailored to the individual Resistance training can be included Exercises will be symptom limited Borg RPE rating should be 12-13 Borg RPE 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 No exertion Very, very light Very light Light Somewhat hard Hard Very hard Very, very hard Maximum exertion Exercise Session • May not be able to achieve target heart rate • Heart rate may have to be adjusted as medications (blockers) are up-titrated Common problems • Symptomatic low BP – check drug dosages / timings • Increase in symptoms – ?overloaded (weight gain) – ? blockers initiated or up-titrated Exercise Session Safety • Higher risk patients - staff ratio should be 1:5 • Some patients may require 1:1 • SCD common • Rare in CHF English CR programme (Wythenshawe) N.B. • Good and bad days - exercise prescription may change (erratic attendance) • Remember fluid restriction when encouraging intake • Gout is common 2° to diuretics Home Exercise Too unfit for class? • Short daily sessions of 5-15 minutes • Simple programme (?e.g. chair programme / pedals) • As fitness improves, increase duration of session & reduce frequency to once per day • Start to increase pace to brisk (12-13 on Borg scale) • With further improvement, aim to gradually build up to accumulation of 30 minutes moderate intensity activity most days General Physical Activity Advice • Do any activity that you enjoy & are used to doing, unless you have been told otherwise • Physical activity is safe if you start slowly & build up gradually • Always exercise within limits of your symptoms • If you use GTN spray or tablets for relief of angina, keep this to hand • If you wish to try a new activity, it’s probably best to check with a health professional first General Physical Activity Advice • • • • Remember you may have good & bad days Avoid sudden bursts of intense activity Always start & end your exercise at a lower pace Take care when exercising in extremes of temperature, or windy weather • Avoid exercising directly after a large meal General Physical Activity Advice • Rest if you have a sore throat, cold, flu, infection / temperature, or if your heart failure suddenly worsened • Restart your programme at an easier pace • If you experience severe chest pain, undue shortness of breath, palpitations, nausea, dizziness, or excessive tiredness during exercise, do not continue - speak to your GP or nurse about this! Swimming • Head-up immersion & hydrostatically-induced volume shift • LV volume loading & heart volume • Physiological effects for easy paced swimming = intense cycling • 2001 guidelines state that patients should refrain • More recent advice: compensated patients can swim • Swim if they are stable & are used to swimming highlight that abilities may be reduced in water (build up gradually) Thank You Any Questions? References & Bibliography ACPICR (2006) Standards for the Exercise Component of Phase III Cardiac Rehabilitation. London: ACPICR European Society of Cardiology (2001) Recommendations for Exercise Training in Chronic Heart Failure Patients. European Heart Journal 22: 125-135 Coats et al (1990) Effect of Physical Training in Chronic Heart Failure. The Lancet 335: 63-66 National Institute for Clinical Excellence (2003) Chronic Heart Failure. London: Clinical Guideline No. 5 Scottish Intercollegiate Guidelines Network (2002) Cardiac Rehabilitation. Edinburgh: SIGN 57 Pilot Study A Study Comparing Validity & Reproducibility of the Shuttle Walk Test and 6-minute Walk Test in Chronic Heart Failure Why? • Inconsistent research examining validity and reproducibility of the walking tests • Literature lacks standardisation of methodology • Most studies conducted out with United Kingdom • Studies use small samples, excluding women and elderly Pilot - Methodology n=28 participants recruited from Heart Failure Nursing Service Randomly familiarised with 1 walking test Treadmill cardio-pulmonary exercise test - STEEP protocol 6 x walking tests (3 x shuttle, 3 x 6 minute walk) - 1 per week Participants undertake walking test familiarised with first Comparisons between data from walking tests & treadmill ANALYSES OF WALKING TESTS’ VALIDITY Comparisons between data from 3 attempts of each walking tests ANALYSES OF WALKING TESTS’ REPRODUCIBILITY Comparisons between reproducibility of tests familiarised with against those not ANALYSES OF EFFECTS OF FAMILIARISATION Pilot - Sample Recruitment from Heart Failure Nurse Liaison Service Inclusion Criteria: • Diagnosis of LVSD by echo • Sufficiently clinically stable for exercise • Willing to participate Exclusion Criteria: • Other life threatening illness • Unable to participate due to major cognitive impairment Progress so far….. • • • • Recruitment slow! Patients need to be optimised on medication Problems with treadmill testing criteria - LBBB Patients reluctant to enrol in “serial testing”, reluctant to travel, reluctant to attend after 4.30pm • Recruitment extended to include those attending Cardiology clinics & attending for echo Data on 7 patients collated to date! Hope++ to complete by Spring 2007