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FIRST TERM UNIFIED QUIZ #2 APRIL 14, 2003 HISTOLOGY 1. Testosterone is produced by: A. B. C. D. E. 2. The proximal tubules of the kidney: A. B. C. D. E. 3. is a component of the basement membrane of the alveolar epithelium Is produced by alveolar macrophages Coats the nasal epithelium Is produced by Type I pneumocytes Decreases the surface tension at the epithelial-air surface The marginal zone of the spleen is: A. B. C. D. E. 6. Are found primarily in thick skin Are holocrine glands Secrete fluid composed primarily of protein and water Are located in the stratum germanitivum Have all of the above features Surfactant: A. B. C. D. E. 5. Exhibit numerous microvilli at the cell surface Are composed of simple squamous epithelium Secrete glucose and amino acids into the glomerular filtrate Lack a basal lamina Are continuous with collecting ducts Sebaceous glands: A. B. C. D. E. 4. Sertoli Cells Type A Spermatogonia Type B Spermatogonia Spermatids Interstitial cells of Leydig Located in the PALS Located in the capsule A site where immune reactions occur Avascular Rich in adipose tissue The bloods vessels that respond to the reduction of withdrawal of progesterone, and that supply the functional layer of the endometrium are: A. B. C. D. E. Spiral arteries Straight arteries Arcuate arteries High endothelial venules (HEVs) The uterine artery 7. The zona pellucida is a site within developing ovarian follicles. The zona pellucida: A. B. C. D. E. 8. Hormones classified as glucocorticoids (like cortisol) are produced in the adrenal cortex in a layer called the: A. B. C. D. E. 9. Glomerulosa Fasciculata Reticularis Chromaffin Medulla The cells that produce the hormone called calcitonin are: A. B. C. D. E. 10. stains dark blue with H&E stain Is present in primordial follicles Is produced by cells of the theca externa Facilitates contact between the oocyte and follicle cells Lies within the tunica albuginea Principle or follicle cells of the thyroid gland Principle or follicle cells of the parathyroid gland Parafollicular or “clear” cells of the thyroid Oxyphil cells of the parathyroid Pinealocytes The epithelial reticular cells (ERCs) contribute to several important functions in the immune system. They are located only in the: A. B. C. D. E. Palatine tonsil Lymph nodules Lymph nodes Lymphatic vessels Thymus EMBRYOLOGY QUESTIONS 11. Which of the following statements about the auditory ossicles is true? They A. B. C. D. E. 12. Regarding the metopic suture A. B. C. D. E. 13. musculature and connective tissue of the trigone of the bladder the canal of Epididymis vas (ductus) deferens ejaculatory duct all of the above The primordial germ cells in the gonads are derived from: A. B. C. D. E. 16. clavicle/intramembranous ossification oxycephaly/premature fusion of sagittal suture muscles of facial expression/first branchial arch third branchial arch/mandibular nerve osteoclasts/bone forming cells The mesonephric duct gives rise to A. B. C. D. E. 15. it is located between the frontal and parietal bones it is located between the two halves of the frontal bone it is seen only in the fetal skull it can normal be seen in the adult skull All of the above are true Which one of the following pairs is correctly matched? A. B. C. D. E. 14. Develop by intramembranous ossification Are derived from the Meckel’s cartilage Are derived from the Reichert’s cartilage Are derived from both the Meckel’s cartilage and Reichert’s cartilage Form a part of the neurocranium surface Mesothelium over the gonadal swelling intermediate mesoderm yolk sac endoderm mesonephros yolk stalk A 19 year old male comes to the clinic with a painless cystic swelling on the right side of the neck at the anterior border of the sternomastoid. The condition is diagnosed as branchial cyst. The branchial cyst results due to failure of: A. B. C. D. E. development of the second branchial arch development of second branchial pouch closure of second branchial groove obliteration of cervical sinus formation of cervical sinus 17. Which of the following participates in the development of tongue? A. B. C. D. E. 18. A part of the gubernaculums is represented in the adult female by the: A. B. C. D. E. 19. broad ligament of the uterus hymen suspensory ligament of the ovary ovarian ligament mesosalpinx The intermaxillary segment is formed by the fusion of: A. B. C. D. E. 20. copula tuberculum impar caudal part of hypobranchial eminence second branchial arch occipital Myotomes maxillary prominences medial nasal prominences lateral nasal prominences medial and lateral nasal prominences maxillary and lateral nasal prominences Treacher Collins syndrome results due to a defective development of: A. B. C. D. E. ultimobranchial body third and fourth branchial pouches first branchial arches third branchial arch fourth branchial arch GROSS ANATOMY 21. Muscles in the anterior compartment of the leg receive most of their arterial blood supply directly from branches of the ___________________ artery. A. B. C. D. E. 22. Paralysis of the tibialis posterior muscle will results in a weakness in: A. B. C. D. E. 23. B. C. D. E. as it passes through the cribriform fascia of the thigh immediately deep to the sartorius muscle as it joins the deep femoral vein in the femoral triangle as it passes deep to the inguinal ligament at the adductor hiatus of the adductor magnus muscle In its normal placement with the pelvic cavity, the uterus lies in a _________________ position. A. B. C. D. E. 26. the terminal branches of the internal pudendal arteries provide the main arterial supply of the erectile tissues of the penis increased parasympathetic activity during sexual arousal increases blood volume in the erectile tissues of the penis penile erection occurs as a consequence of the engorgement of the cavernous sinuses in the corpora cavernosa of the penis secretions from the seminal vesicles and prostate gland contribute to the composition of semen during emission All of the above are correct The femoral vein becomes the external iliac vein: A. B. C. D. E. 25. extension of the toes flexion of the toes dorsiflexion of the foot eversion of the foot inversion of the foot Which of the following statements concerning penile erection and ejaculation is/are correct? A. 24. popliteal anterior tibial posterior tibial fibular (peroneal) dorsalis pedis prolapses anteverted – retroflexed retroverted – anteflexed retroverted – retroflexed anteverted – anteflexed The glans clitoris: A. B. C. D. E. sends most of its lymphatic drainage into inguinal lymph nodes does not have a homologue in the male is the distal continuation of the corpora cavernosa receives sensory innervation from branches of the genitofemoral nerve is correctly described in all of the above 27. The biceps femoris muscle: A. B. C. D. E. Inserts on the fibula Acts in flexion of the thigh Is innervated by the femoral nerve Forms one boundary of the femoral triangle Is correctly described in all of the above 28. The pain and itching from a mosquito bite in the skin overlying the belly of the rectus femoris muscle is carried toward the CNS by branches of the _______________ nerve. A. B. C. D. E. femoral sural lateral femoral cutaneous posterior femoral cutaneous saphenous 29. The muscle forming the lateral border of the carotid triangle receives its motor innervation from the branches of the _____________________ nerve. A. B. C. D. E. 30. hypoglossal trigeminal ansa cervicalis spinal accessory vagus Forming a portion of the viscerocranium is the __________ bone. A. B. C. D. E. hyoid ethmoid vomer sphenoid frontal BIOCHEMISTRY 31. A researcher produces a “knock-out” mouse in which both copies of the gene for PI 3 kinase (Phosphatidylinositol 3-kinase) are disrupted. Which of the following processes will be most affected? A. B. C. D. E. 32. Cystic fibrosis is caused by mutation in the gene for a protein which has been named CFTR. Which of the following proteins shows the greatest sequence homology to CFTR? A. B. C. D. E. 33. Glycophorin Multi-Drug-Resistance Protein Glucose transporter GLUT-2 The protein which is deficient in Tay-Sachs disease Apolipoprotein E Carnitine is involved: A. B. C. D. E. 34. Release of Ca2+ from liver ER in response to glucagons Synthesis of sphingomyelin in regenerating nerve Inhibition of glycogen synthase kinase in response to insulin Activation of membrane associated phospholipase C Activation of hormone-sensitive lipase in adiposities in transporting short chain fatty acids into the mitochondrial matrix in transporting fatty acids into the ER, where they can undergo desaturation in the conversion of acetyl-CoA to ketone bodies in transporting long chain acyl groups into the mitochondrial matrix the allosteric regulation of acetyl-CoA Dehydrogenase Deficiency of which of the following enzymes is associated with elevated serum triacyglycerol (TAG) levels? A. B. C. D. E. Lipoprotein lipase Acetyl-CoA Carboxylase Pancreatic lipase Fatty acid synthase Phosphatidate phosphohydrolase 35. A 40 year old man made a good recovery following a myocardial infarction. Lovastatin was prescribed by his cardiologist. Which of the following will be a result of his therapy? A. B. C. D. E. 36. Reduced plasma HDL levels Elevated plasma cholesterol levels Excessive bile secretion Reduced plasma LDL levels Reduced hepatic TAG synthesis Which of the following statements concerning the B-form of DNA is FALSE? A. B. C. D. E. The two DNA chains run in opposite directions G on one strand makes 3 hydrogen bonds with an A on the other strand The double-helix makes one complete turn every 10 nucleotides Most of the DNA found naturally in cells exist in the B-form Nucleotides in the individual chains are joined by 3’,5’-phosphodiester linkages 37. Which of the following proteins or activities is responsible for removal of RNA primers during DNA replication in E.Coli? A. B. C. D. E. 38. Which of the following statements concerning transcription is TRUE? A. B. C. D. E. 39. DNA gyrase 3’--->5’ exonuclease of Pol I 5’--->3’ exonuclease of Pol I telomerase rep protein RNA polymerases require an RNA primer in order to function Sigma factor is required for termination of transcription in prokaryotes Three RNA polymerases are involved in transcription in eukaryotes In prokaryotes transcription starts at the Shine-Dalgarno sequence Removal of introns from the primary transcript occurs in prokaryotes Which of the following statements concerning the genetic code is FALSE? A. B. C. D. E. it is an overlapping code it is a degenerate code it uses no punctuation except for stop and start signals It is a triplet code 61 codons code for amino acids 40. The toxin produced by Corynebacterium diphtheriae, the cause of diphtheria, interferes with translation by its effect on which of the following protein factors? A. B. C. D. E. EF-Tu RF-2 IF-2 Rho factor EF-2 ANSWER KEY Histology 1. E 2. A 3. B 4. E 5. C 6. A 7. D 8. B 9. C 10. E Embryology 11. D 12. B 13. A 14. E 15. C 16. D 17. E 18. D 19. B 20. C Anatomy 21. B 22. E 23. E 24. D 25. E 26. A 27. A 28. A 29. D 30. C Biochemistry 31. C 32. B 33. D 34. A 35. D 36. B 37. C 38. C 39. A 40. E