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3070 OBESITY AND CONGESTIVE HEART FAILURE M.A. Alpert University of Missouri School of Medicine, Columbia, MO, USA Obesity, particularly morbid obesity, produces alterations in cardiac hemodynamics, cardiac morphology and ventricular function that may predispose to congestive heart failure (CHF). Increased circulating blood volume, stroke volume and cardiac output coupled with decreased systemic vascular resistance may lead to eccentric left ventricular (LV) hypertrophy, LV diastolic dysfunction and LV systolic dysfunction. This provides a substrate for obesity-induced CHF, often referred to as obesity cardiomyopathy. Substantial weight loss reverses many of the changes in cardiac structure and function as well as many of the clinical manifestations of obesity cardiomyopathy. Right ventricular failure may result from LV failure and may be facilitated by pulmonary hypertension due to sleep apnea/obesity hypoventilation. Case control and community-based studies have shown that overweight and mildly to moderately obese individuals are also at risk for CHF. Multivariate analysis has identified obesity as an independent predictor of CHF is such persons. Obesity is associated with reduced survival over time. However, obese patients with CHF survive longer than lean patients with comparable degrees of CHF, regardless of etiology. This phenomenon is referred to as the "obesity paradox". CHF may be difficult to diagnose clinically in obese patients. Plasma levels of B-type natriuretic peptide (BNP) or N-terminal pro-BNP, which are quite useful in confirming CHF in lean patients, are lower in obese persons with or without CHF, thus reducing sensitivity.