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1 The Digestive System Digestive System Components A. Alimentary canal (also called the Gastrointestinal “GI” Tract)– continuous, muscular digestive tube that winds through the body (30 ft. long when dead & relaxed, shorter when alive due to muscular tone.) The GI tract is considered outside the body. http://ww w.youtube .com/watc h?v=Z7xK YNz9AS0 1. 2. 3. 4. 5. 6. oral cavity pharynx esophagus stomach small intestine large intestine B. Accessory Digestive Organs 1. salivary glands 2. tongue 3. teeth 4. pancreas 5. liver 6. gallbladder Digestive Processes http://trc.ucdavis.edu/biosci10v/bis10v/week10/digestive.gif A. Ingestion: taking food into digestive tract (through mouth) http://www.youtube.com/watch?v=Ri8bBhw9ms B. Propulsion: moving food through alimentary canal Q&NR=1 a. swallowing: voluntarily initiated b. peristalsis: involuntary - alternate waves of contraction & relaxation of muscles in the organ walls (squeeze food one direction along tract) C. Mechanical digestion: (physical) chewing, tongue mixing food w/ saliva, churning food in stomach, and segmentation (rhythmic local constrictions that can move the food back & forth) within the small intestine → mixes food w/ digestive juices D. Chemical digestion: catabolic steps by enzymes secreted into lumen (hollow open tube of intestine); begins in mouth and is complete in the small intestine E. Absorption (small intestine) – digested product (food that has been broken down into molecules) from lumen passes through mucosal cells into blood or lymph F. Defecation – elimination of indigestible substances (fecal matter: fiber, bacteria, mites, protozoans, viruses) 2 Supporting Structures A. Peritoneum – serous membrane that lines the organs and the abdominal cavity. This membrane secretes serous fluid for protection. 1. Visceral peritoneum – covers external surface of organs & is continuous w/ the parietal peritoneum 2. Parietal peritoneum – lines the wall of the abdominal cavity http://www.finejewelrydesigns.com/images/peritoneum-chart.jpg B. Mesentery/Mesocolon – a double layer of the peritoneum that extends to the digestive organs, anchoring every organ to the wall of the abdominal cavity. A. Hold organs in place and stores fat (curtain over intestines for protection) B. Contains blood vessels, lymph vessels, and nerves. Provides a place for these vessels and nerves, yet prevents entanglement and allows them to pass through to other areas. C. Greater Omentum a double layer of the peritoneum that extends over the organs in the digestive system. Functions in fighting disease by holding a great number of lymph nodes. D. Histology: 1. Mucosa (inner-most layer, moist epithelial membrane) secretes mucus, digestive enzymes, and hormones absorbs products of digestion into blood protects against infectious disease 2. Submucosa - connective tissue w/ blood vessels, lymph vessels, nerves, & elastic fibers that allow the organ to return to normal shape 3. Muscularis – muscle layer, has an inner-circular (runs around the lumen) and an outer-longitudinal (runs lengthwise w/ lumen) layer of smooth muscle; inner circular layer also thickens to form sphincters 4. Serosa – the visceral peritoneum in GI tract; layer that wraps the organs http://www.lib.mcg.edu/edu/eshuphysio/program/section6/6ch1/6ch1img/page4.jpg 3 E. Innervation: 1. Enteric plexi – a “network” of branched nerves attached to the submucosa within the walls of the GI tract. Includes the Submucosal plexus and the Myenteric plexus http://www.vivo.colostate.edu/hbooks/pathphys/digestion/basics/ginerves.gif 2. The Enteric Nervous System is linked to the Central Nervous System the parasympathetic nervous system stimulates digestion “rest and digest” the sympathetic nervous system inhibits digestion “fight or flight” Oral Cavity & Associated Organs A. Mouth – mucosal lined cavity continuous w/ oropharynx (throat) 1. Hard and Soft Palate (roof of mouth) 1. hard – anterior 2. soft – posterior; rises to close off nasopharynx when swallowing 3. uvula – flap attached to soft palate - involved in sleep apnea 2. Tongue – mixes food w/ saliva = bolus a. intrinsic muscles – change shape of tongue (rolls tongue in) b. extrinsic muscles – alters position of tongue (stick tongue out, touch roof of mouth) c. lingual frenulum – holds tongue to floor of mouth, limits movement (function: prevents us swallowing tongue) d. filiform papillae = roughness – specks on tongue NOT tastebuds (cats have pronounced filiform papillae needed to lap & “grab” food) http://kbb.uludag.edu.tr/image/oralkaviteders/Resim-6.jpg from 4 3. Salivary glands a. Parotid – anterior to ear, between masseter muscle and skin (large muscle in jaw) b. Submandibular – medial aspect of mandible body; opens at lingual frenulum c. Sublingual – under tongue laterally – lies on both sides of tongue, underneath http://health.yahoo.com/media/mayoclinic/images/image_popup/ah6a192.jpg d. Saliva characteristics: 1000-1500 ml produced on average per day pH of 6.75 – 7 (slightly acidic) Cleans mouth, dissolves food so you can taste, moistens food Contains salivary amylase (from parotid gland) that starts the breakdown of starch only Contains mucin (mixes w/ water → mucus), lysozyme (also in tears & cells, it’s a chemical that breaks down cells, attacks & kills bacteria), and IgA (antibody→fights infection) Sympathetic effect = decrease in production → dry mouth 5 4. Teeth a. deciduous teeth – 20 “baby teeth” b. permanent teeth – 32 including wisdom c. anatomy: crown – exposed part; covered by enamel root – part embedded in jaw bone neck – connect crown & root (just below gumline) gingival – gum enamel – hardest substance in body, mineralized Ca+ salts – covers outer crown; cells that make enamel degenerate after tooth erupts through gums; dentin – bone like http://www.mydr.com.au/content/images/categories/dental/tooth_ material under enamel = anatomy_vs2.gif bulk of tooth (gets damaged when bacteria gets through enamel) pulp/cavity – supplies nutrients & tooth sensation; connective tissue, blood vessels, nerves periodontal ligament (membrane) – anchors tooth in jaw Pharynx –passageway for food, fluid, and air (air only →unique to nasopharynx) nasopharynx – air only oropharynx – behind oral cavity, food/fluids/air laryngopharynx – near larynx (larynx connected to esophagus or trachea) , food/fluids/air http://www.youtube.com/watch?v=DB_E2BygPJk&feature=related glottis & epiglottis Esophagus – food enters when epiglottis (at top of larynx) closes off trachea to food 1. Esophagus- pierces diaphragm to enter abdomen 2. Joins stomach at gastroesophageal or cardiac sphincter (at top of stomach; improper function → acid reflux) 3. Uses peristalsis to move food to stomach http://www.youtube.com/watch?v=hm1nEPHxJ0E&feature=related 6 Stomach – mainly a storage area where chemical breakdown of protein begins & food is converted to chyme Functions: 1. Holding place for food so that it can enter the duodenum gradually 2. Churns and mixes food – becomes “chyme” 3. Begins digesting proteins 4. Absorbs water, aspirin, alcohol, and electrolytes Borborygmi Main structures: “J-shaped” = “stomach 1. Cardiac Sphincter growling” 2. Cardia 3. Fundus 4. Body 5. Pylorus 6. Pyloric Sphincter 7. Rugae: folds in mucosa that allow for stretching when stomach is full http://www.rivm.nl/interspeciesinfo/Images/stomach_tcm75-26442.gif 3 layers of smooth muscle in muscularis instead of 2: 1. **Inner oblique smooth muscle layer (diagonal) found only in the stomach that allows the stomach to churn food 2. Middle circular smooth muscle layer (around stomach) 3. Outer longitudinal smooth muscle layer (lengthwise) Gastric glands: made of cells found in deep pits in the mucosa of the stomach 1. mucus made by mucous cells 2. HCL made by parietal cells needed to activate pepsinogen into pepsin (digests proteins) and kill Collectively bacteria these 3. Intrinsic factor made by parietal cells substances, not including required for vitamin B12 absorption in the gastrin, small intestine are called 4. pepsinogen made by chief cells gastric juice breaks down proteins into smaller component must be activated by HCL first – called pepsin once activated 5. enteroendocrine cells or G-cells – releases gastrin into the blood which stimulates the stomach