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This cancer survivorship algorithm has been specifically developed for MD Anderson using a multidisciplinary approach and taking into consideration circumstances particular to MD Anderson, including the following: MD Anderson’s specific patient population; MD Anderson’s services and structure; and MD Anderson’s clinical information. This algorithm is provided as informational purposes only and is not intended to replace the independent medical or professional judgment of physicians or other health care providers. Moreover, this algorithm should not be used to treat pregnant women. ELIGIBILITY CONCURRENTLY History and physical with clinical breast exam annually 2 ● Screening mammogram annually ● Assess for compliance with hormone therapy and assess for toxicities ● SURVEILLANCE Suspect new primary or biopsyproven recurrence? Yes No Male or Female with Invasive Breast Cancer 5 years from date of diagnosis1, No evidence of Disease MONITORING FOR LATE EFFECTS Consider the following: 3 ● Bone Health (See Breast Cancer Survivorship: Bone Health Algorithm) ● Cardiac screening ● Patient education regarding symptoms including radiotherapy complications if appropriate ● Lymphedema assessment ● Sexual health/fertility RISK REDUCTION/ EARLY DETECTION Consider the following: ● Gynecologic screening (See Cervical Screening Algorithm) ● Colorectal screening (See Colorectal Screening Algorithm) ● Diet/weight management counseling PSYCHOSOCIAL FUNCTIONING Assess for: ● Distress ● Financial stressors Continue survivorship monitoring Fatigue assessment Neuropathy assessment ● Assess for cognitive dysfunction ● Gynecological assessment if on tamoxifen ● ● Exercise/activity ● Tobacco cessation counseling ● Sun exposure/skin cancer screening ● Vaccinations ● Genetic screening ● See Evaluation for Recurrence on Invasive Breast Cancer Algorithm Refer or consult as indicated Body image ● Social support ● 1 Completion of all treatment with the exception of hormonal agents Consider tomosynthesis/ 3D mammogram 3 Premenopausal women on hormonal therapy 2 Copyright 2016 The University of Texas MD Anderson Cancer Center Department of Clinical Effectiveness V6 Approved by the Executive Committee of the Medical Staff 11/24/2015 This cancer survivorship algorithm has been specifically developed for MD Anderson using a multidisciplinary approach and taking into consideration circumstances particular to MD Anderson, including the following: MD Anderson’s specific patient population; MD Anderson’s services and structure; and MD Anderson’s clinical information. This algorithm is provided as informational purposes only and is not intended to replace the independent medical or professional judgment of physicians or other health care providers. Moreover, this algorithm should not be used to treat pregnant women. SUGGESTED READINGS Buzdar AU. (2004). Hormonal therapy in early and advanced breast cancer. Breast J; 10 Suppl 1:S19-21 Giordano SH, Booser DJ, et al. (2002). “A detailed evaluation of cardiac toxicity: a phase II study of doxorubicin and one- or three-hour-infusion paclitaxel in patients with metastatic breast cancer. Clin Cancer Res; 8:3360-8. Hillner BE, Ingle JN, Berenson JR, et al. (2000). American Society of Clinical Oncology guideline on the role of bisphosphonates in breast cancer. American Society of Clinical Oncology Bisphosphonates Expert Panel. Journal of Clinical Oncology; 18(6), 1378-1391. Hillner BE, Ingle JN, Chlebowski RT, et al. (2003). American Society of Clinical Oncology 2003 update on the role of bisphosphonates and bone health issues in women with breast cancer. [erratum appears in J Clin Oncol. 2004 Apr 1;22(7):1351]. Journal of Clinical Oncology, 21(21), 4042-4057. Howell A, Cuzick J, Baum M, et al. (2005). Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer. Lancet; 365(9453):60-2. NCCN Clinical Practice Guidelines in Oncology, Breast Cancer V.3.2014. www.nccn.org Pavlakis N, Schmidt R, Stockler, M., & Schmidt, R. (2005). Bisphosphonates for breast cancer. Cochrane Database of Systematic Reviews(3), CD003474. Reid DM, Doughty J, Eastell R, et al. (2008). Guidance for the management of breast cancer treatment-induced bone loss: a consensus position statement from a UK Expert Group. Cancer Treatment Reviews; 34 Suppl 1, S3-18. Copyright 2016 The University of Texas MD Anderson Cancer Center Department of Clinical Effectiveness V6 Approved by the Executive Committee of the Medical Staff 11/24/2015 This cancer survivorship algorithm has been specifically developed for MD Anderson using a multidisciplinary approach and taking into consideration circumstances particular to MD Anderson, including the following: MD Anderson’s specific patient population; MD Anderson’s services and structure; and MD Anderson’s clinical information. This algorithm is provided as informational purposes only and is not intended to replace the independent medical or professional judgment of physicians or other health care providers. Moreover, this algorithm should not be used to treat pregnant women. DEVELOPMENT CREDITS This survivorship algorithm is based on majority expert opinion of the Breast Survivorship work group at the University of Texas MD Anderson Cancer Center. It was developed using a multidisciplinary approach that included input from the following medical, radiation and surgical oncologists. Therese Bevers, MD Carlos Barcenas, MD Isabelle Bedrosian, MD Basak Dogan, MD Gabriel N. Hortobagyi, MD Kelly Hunt, MD Jessica Leung, MD Paula Lewis-Patterson, MSN, RN, DNP, BSN Stacy Moulder, MD Simona Shaitelman, MD Welela Tereffe, MD Debu Tripathy, MD Vicente Valero, MD Copyright 2016 The University of Texas MD Anderson Cancer Center Department of Clinical Effectiveness V6 Approved by the Executive Committee of the Medical Staff 11/24/2015