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BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME POSITION TITLE Carol Toris, Ph.D. eRA COMMONS USER NAME (credential, e.g., agency login) ctoris Professor, Department of Ophthalmology and Visual Sciences EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) INSTITUTION AND LOCATION Rockford College, Rockford, IL University of Minnesota, St. Paul, MN University of Minnesota, St. Paul, MN DEGREE (if applicable) MM/YY BA MS Ph.D. 08/69-05/73 09/77-08/79 09/84-01/90 FIELD OF STUDY Biology Animal Physiology Physiology A. Personal statement. I have been studying aqueous humor dynamics since I was a graduate student in the 1980s. My expertise is in the area of IOP and ocular fluid dynamics. I became Director of Glaucoma Research at the University of Nebraska Medical Center in 1990. I have published numerous papers on aqueous humor dynamics in rabbits, cats, dogs, monkeys, and mice. Additionally I have conducted clinical studies of healthy people, patients with ocular hypertension and various ocular syndromes and patients taking intraocular pressure lowering drugs at different times of the day and night. My team is comprised of research technicians, animal handlers, and a glaucoma specialist. Both clinical and animal studies make our work truly translational. We are well skilled and equipped to undertake the experiments proposed in mice. B. Positions and Honors Positions and employment 10/90-06/01 03/93-Present 03/93-06/01 07/01-06/07 07/07-Present Assistant Professor, Department of Ophthalmology, University of Nebraska Medical Center, Omaha, NE Member, Graduate Faculty, University of Nebraska Medical Center, Omaha, NE Assistant Professor, Courtesy Appointment, Department of Physiology, University of Nebraska Medical Center, Omaha, NE Director of Glaucoma Research and Tenured Associate Professor, Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE Associate Professor, Courtesy Appointment, Department of Physiology, University of Nebraska Medical Center, Omaha, NE Director of Glaucoma Research and Tenured Professor, Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE Professor, Courtesy Appointment, Department of Physiology, University of Nebraska Medical Center, Omaha, NE Other Experience and Professional Memberships 2004-Present American Physiological Society 2003-Present American Glaucoma Society 1984-Present Association for Research in Vision and Ophthalmology (ARVO), Trustee 1996-Present International Society for Ocular Fluorometry 1986-Present International Society for Eye Research (ISER) 1995-Present Association for Ocular Pharmacology and Therapeutics (AOPT), Trustee Honors 1969-1973 Jane Addams Scholarship, Rockford College 1989 1993 2006 2009 2010 IJ Fox Memorial Award for graduate research in physiology, University of Minnesota Ruth Salta Junior Investigator Achievement Award, American Health Assistance Foundation Dr. Stan Truhlsen Research Award, Prevent Blindness Nebraska ARVO FARVO, Gold award Silver U Award, UNMC C. Selected peer-reviewed publications most relevant to current application 1. Borghi V, Bastia E, Guzzetta M, Chiroli V, Toris CB, Batugo MR, Carreiro ST, Chong WKM, Gale DC, Kucera DJ, Liu J, Prasanna G, Kallberg ME, Ongini E, Krauss AHP and Impagnatiello F. A novel nitric oxide releasing prostaglandin derivative, NCX 125, reduces intraocular pressure in rabbit, dog and primate models of glaucoma. Journal of Ocular Pharmacology and Therapeutics 2010 26(2): 125-132. PMID: 20415621 2. Zhao M, Hejkal JJ, Camras CB, Toris CB. Aqueous Humor Dynamics during the Day and Night In Juvenile and Adult Rabbits. Invest Ophthalmol Vis Sci. 2010 51(6): 3145-51. 3. Camras LJ, Sufficool KE, Camras CB, Fan S, Liu H, Toris CB. Duration of anesthesia affects intraocular pressure, but not outflow facility in mice. Curr Eye Res. 2010 Sep;35(9):819-27. PMID: 20795864 4. Toris CB, Risma JM, Gonzales-Martinez J, McLaughlin MA, Dawson WW. Aqueous humor dynamics in inbred rhesus monkeys with naturally occurring ocular hypertension. Exp Eye Res. 2010;91:860-865. PMID: 20868683 5. Krauss A, Impagnatiello F, Toris CB, Gale D, Prasanna G, Borghi V, Chiroli V, Chong WK, Carreiro S, Ongini E. Ocular hypotensive activity of BOL-303259-X, a nitric oxide donating prostaglandin-F2alpha agonist, in preclinical models. Exp Eye Res. 2011 Sep;93 (3):250-5. PMID: 21396362 6. Prasanna G, Carreiro S, Anderson S, Gukasyan H, Sartnurak S, Younis H, Gale D, Xiang C, Wells P, Dinh D, Almaden C, Fortner J, Toris CB, Niesman MR, LaFontaine J, Krauss AH Effect of PF04217329 a Pro-Drug of a Selective Prostaglandin EP2 Agonist on Intraocular Pressure in Preclinical Models of Glaucoma, Exp Eye Res. 2011 Sep;93 (3):256-64 PMID: 21376717 Additional recent publications of importance to the field (in chronological order) 1. Johnson TV, Fan S, Zhan GL, Camras CB, Toris CB. Efficacy and mechanisms of intraocular pressure reduction with latanoprost and timolol in subjects with ocular hypertension: a comparison of one and six weeks of treatment. J Glaucoma. 2010 Aug;19(6):356-64. PMID: 20179619 2. Toris CB, Haecker N, Teasley L, Zhan G, Gulati V, Camras CB. Aqueous humor dynamics in pigment dispersion syndrome. Arch Ophthalmol. 2010;128(9):1115-1118 PMID: 20837793 3. Lane JT, Larson L, Fan S, Stoner JS, Margalit E, Toris CB. Intraocular Pressure, Blood Pressure, Ocular Blood Flow, Outflow Facility and Aqueous Humor Flow During a Euglycemic-Hyperinsulinemic Clamp in Patients With Type 1 Diabetes With Microalbuminuria and Retinopathy. BMC Ophthalmol. 2010 Jun 23;10:19. PMID: 20573241 4. Gulati V, Ghate DA, Camras CB, Toris CB. Correlations between Central Corneal Thickness and Aqueous Humor Dynamics. Invest Ophthalmol Vis Sci. 2011 Feb 16;52(2):920-6. PMID: 20881287 5. Liu H, Fan S, Gulati V, Camras LJ, Zhan G, Ghate D, Camras CB, Toris CB. Aqueous humor dynamics during the day and night in healthy mature volunteers. Arch Ophthalmol. 2011 Mar;129(3):269-75. PMID: 21402980 6. Ahmad I, Balasubramanian S, Del Debbio C, Parameswaran S, Katz AR, Toris C, Fariss RN. Regulation of ocular angiogenesis by Notch signaling: implications in neovascular age-related macular degeneration. IOVS, 2011 May 2;52(6):2868-78. PMID: 21228388 7. Fan S, Hejkal JJ, Gulati V, Galata SL, Camras CB, Toris CB. Aqueous humor dynamics during the day and night in volunteers with ocular hypertension. Arch Ophthalmol. 2011 Sep;129(9):1162-6. PMID: 21911663 8. Gulati V, Fan S, Maslonka M, Gangahar C, Toris CB, Diurnal and Nocturnal Variations in Aqueous Humor Dynamics of Patients with Ocular Hypertension on Medical Therapy. Arch Ophthalmol. 2012 Jun;130 (6):677-84. PMID: 22332206 9. Camras LJ, Yuan F, Fan S, Samuelson TW, Ahmed IK, Schieber AT, Toris CB. A Novel Schlemm’s Canal Scaffold Increases Outflow Facility in a Human Anterior Segment Perfusion Model. Invest Ophthalmol Vis Sci 2012 Sep 12;53(10):6115-21. PMID: 22893672 10. Harms NV, Toris CB.Current status of unoprostone for the management of glaucoma and the future of its use in the treatment of retinal disease. Expert Opin Pharmacother. 2013 Jan;14(1):105-13. PMID: 23199345 11. Gulati V, Fan S, Hays CL, Samuelson TW, Ahmed I, Toris CB. A Novel 8-mm Schlemm’s Canal Scaffold Reduces Outflow Resistance in a Human Anterior Segment Perfusion Model. Invest Ophthalmol Vis Sci. 2013;54:000–000. PMID: 23372057 12. Gulati V, Pahuja P, Fan S, Toris CB. An Experimental Steroid Responsive Model of Ocular Inflammation in Rabbits using an SLT Frequency Doubled Q Switched Nd: YAG Laser. J. Ocular Pharm Therap, 2013 Sep;29(7):663-9. PMID: 23600959 13. Grierson I, Saheb H, Kahook MY, Johnstone MA, Ahmed IK, Schieber AT, Toris CB. Novel Schlemm’s Canal Scaffold: Histological Observations, J of G, accepted. 14. Fan S, Gulati V, Neely DG, Agrawal A, Toris CB. Day and nighttime effects of brimonidine on IOP and aqueous humor dynamics in participants with ocular hypertension, J of Glaucoma, accepted. D. Ongoing Research Support Toris ACTIVE No number 01/01/14-04/30/14 0.60 calendar months Bascom Palmer seed grant $21,000 New endogenous lipid entities to fulfill unmet needs for glaucoma treatment The goals of this project are to determine the mechanism whereby endogenous lipids can lower intraocular pressure. No number 11/26/13-03/31/2014 0.60 calendar months Nicox $11,220 Nitric oxide donating compounds for the treatment of glaucoma The goals of this project are screen and select new nitric oxide donating compounds for use in glaucoma therapy. No number 01/01/2011-03/31/2014 3.12 calendar months Alcon Research, Ltd. $215,017 Glaucoma Monkey Model This study uses monkeys with laser induced glaucoma to study efficacy and mechanism of action of glaucoma drugs. No number 07/01/2012-06/30/2014 0.36 calendar months Ivantis, Inc. $30,843 Evaluation of Outflow Facility in Human Donor Eyes Implanted with a New Glaucoma Drainage Device The major goals of this project are to determine whether a new glaucoma drainage device increased outflow facility in donated human eyes. No number 01/01/2011-12/31/2014 0.24 calendar months Allergan, Inc. $1,261,754 Effects of Ocular Hypotensive Agents on Aqueous Humor Dynamics in Glaucoma Monkeys This study uses monkeys with laser induced glaucoma to study efficacy and mechanism of action of glaucoma drugs. 1-R01-EY022124-01 05/14/2012-02/28/2014 1.20 calendar months University of Michigan $76,973 Aqueous Humor Dynamics Components that Determine Intraocular Pressure Variance The major goals of this project are to determine if components of aqueous humor dynamics can predict whether a person is a responder or non-responder when dosed with a glaucoma drug. 1K23EY023266-01 (Gulati) 04/01/2013-03/31/2018 0.12 calendar months DHHS/NIH/NEI $221,790 Study of Aqueous Humor Dynamics in a Pediatric Population The major goals of this project are to determine whether aqueous humor dynamics in children is different from adults.