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Strauss MSICS Curriculum © Use of MSICS as a Stimulus for Development This program is designed to facilitate the development of surgical skills and leadership capacity. An emphasis is placed on the tools needed for development of successful indigenous eye teams. Glenn Strauss, MD Strauss MSICS Development Curriculum © Used by permission Glenn H Strauss, MD revised for 2009-2010 Curriculum Overview Chapter 1. Why MSCIS? Pg 3 - 4 A. Efficient technique for addressing the spectrum of surgical problems associated with end stage cataracts B. Decreased dependency on advanced technology C. Safety and improved outcomes of a scleral tunnel procedure Chapter 2. Curriculum goals A. Surgeon effectiveness B. Successful small scale cataract projects C. Training of trainers Pg 5 - 6 Chapter 3. Challenges for the transitioning surgeon A. Transitioning from phacoemulsification to MSICS B. Transitioning from classic ECCE to MSICS Pg 7 - 8 Chapter 4. Core MSICS knowledge Pg 9 - 22 Section 1. Understanding the fundamentals of the MSICS technique Pg 9-12 Section 2. Cataract surgical categories and patient selection Pg 12-14 Section 3. Associated clinical findings requiring technique modifications Pg 14-17 Section 4. Managing intraoperative complications in a low tech environment Pg 17-20 Section 5. Management of postoperative complications Pg 20-22 Chapter 5. Core MSICS surgical skills A. Surgical fundamentals B. Anesthesia options C. Scleral tunnelling D. Capsular manipulation E. Nucleus manipulation F. Cortical manipulation G. Management of ocular co-morbidities and surgical complications 1 Pg 23 - 24 Chapter 6. Using MISCS as a stimulus for development of the ophthalmic community Pg 25 - 29 Section 1. Developing the disciplines needed for success Section 2. The vision restoration paradigm Section 3. Developing a successful MSICS team Section 4. Foundations for the development of an eye care industry Chapter 7. Training of trainers Pg 30 - 31 A. Using the “Head, Hands, Heart” surgical training concept B. Communication tips Final notes: The importance of surgeon advocacy 2 Pg 31 Chapter 1. Why MSICS? Since the 1980’s, advances in cataract surgery have benefited patients around the world. Scleral tunnel techniques combined with high tech tools for phacoemulsification have contributed enormously to patient safety and the quality of outcomes. Until recently, these advances have been of little benefit to developing nations. MSICS has been developed by a number of surgeons applying the principles learned from modern cataract surgery. MSICS is not second rate surgery for the masses. It is an advancement in cataract surgery that makes the benefits of scleral tunnel techniques available to developing nations. When done properly, it is a high quality, elegant procedure. The benefits of MSICS can be summarized as follows: Efficient technique for addressing the spectrum of surgical problems associated with end stage cataracts Chronic lack of access to surgical eye care has resulted in the development of a worldwide patient population with what can best be described as end stage cataracts. MSCIS is proving itself to be the right technique for this patient population. Phaco is designed for the challenges of cataract removal in developed nations not for the many presentations of end stage cataracts found in developing nations. These distinct patient pools must be approached differently but without compromising quality. Decreased dependency on advanced technology Historically, advances in cataract surgery have been driven by technology. However, much of the need for cataract surgery is in nations where use of advanced technology is currently not sustainable due to the high cost of buying and maintaining the technology. Developing nations are full of broken or useless medical equipment obtained with the hope of progress but without a real understanding of the challenges. It has been shown that phacoemulsification can be used to provide premium service at a price high enough to partially subsidize service to the indigent. But MSCIS provides a high quality alternative without the technology and the cost. MSCIS represents advancement in technique without dependency on technology. Safety and improved outcomes of a scleral tunnel procedure In many cultures, cataracts are considered to be a normal consequence of old age. Blindness is perceived as a fate to be endured rather then corrected. Cataract surgery is a choice for the desperate not a valued service for the aging. In such cultures it is critical to offer a procedure that inspires the confidence of the people. There is a growing body of literature reporting the safety and outcomes of MSCIS. Comparisons with the gold standard, phacoemulsification, are favourable. But patients themselves decide the value of a medical procedure. If a patient waits weeks before the vision improves, they are much less likely to consider the procedure to have been successful 3 even if they end up with good vision. MSICS is an important advancement for developing nations making the operative experience and recovery quick and comfortable. From the surgeons point of view, improved operative efficiency and decreased postoperative complications also decreases cost and increases availability of time to generate more income. Combined with the lower cost of the equipment and consumables, MSCIS has the potential to improve surgeon satisfaction by increasing income as well as improving outcomes. Both of these factors are imperative for the development of an eye care industry sustained by meeting the needs of the population it serves. 4 Chapter 2. Curriculum goals This curriculum is designed for cataract surgeons seeking new skills for addressing the problem of treatable blindness. It is not a comprehensive curriculum for those who are just beginning their surgical training. The purpose here is to broaden and refine the skills of the new or established surgeon, challenging the talented among them to be the foundation for the next generation of eye care in developing nations. Young surgeons must be encouraged to stay in developing nations by providing them tools that make their work satisfying and valued. Training of cataract technicians may be appropriate in certain circumstances. Additional curriculum can easily be added for establishing the basics of ophthalmic surgery. The question of just how much surgical training is required to be safe for the public trust is beyond the scope of this curriculum. Goal #1: Surgeon effectiveness The goal of this curriculum is to produce surgeons who effectively address the problem of cataract blindness in developing nations. In most cases this means a surgeon should be able to sustain approximately 2,000 cases per year with 90% of cases achieving good outcomes defined in this curriculum as 6/24 or better uncorrected vision (note WHO standard is 90% 6/18 or better). Mastering MSICS skills is an important skill needed to reach this goal but this curriculum also addresses key leadership elements needed for success. This curriculum is focused on mentoring the ophthalmic surgeons who must take responsibility for meeting the needs of their own people. Sadly, ophthalmic surgeons in developing nations often find themselves serving the needs of visiting surgeons rather then the other way around. This curriculum is designed to put the emphasis where it belongs. Goal #2: Successful small scale cataract projects In developing nations where successes are rare, even small scale successes can have a major impact. The goal of this curriculum is more than just transferring a technical skill. It is also designed to produce successful small scale cataract surgery projects using the new MSCIS skills as the stimulus for change in the ophthalmic community. Hopefully, this success becomes contagious and produces regional as well as local change. Goal #3: Training of trainers The final step in this curriculum is the development of the skills needed to train others. Communication techniques and training strategies can be taught, the effectiveness of a trainer also relates to their desire for the success of others. This curriculum assumes that the trainer is devoted to the success of their trainees: allowing for learning opportunities, mistakes, and respectfully addressing specific weaknesses. Trainees will imitate much of what they have experienced as they train others. In developing nations, the relationship that forms between the trainer and the trainee can become an important factor for ongoing success 5 and should not be underestimated. It is the hope of this author that this curriculum will provide many opportunities for these valuable relationships to develop. 6 Chapter 3. Challenges for the transitioning surgeon Transitioning from phacoemulsification to MSICS Western surgeons, well trained in phacoemulsification, typically find that the challenges of end stage cataract pathology frustrate even their best efforts. Their usual technique and their surgical tricks are insufficient when the prevalence of rock hard nuclei and zonular pathology is high. While careful case selection can certainly yield good phaco candidates, this does not address the most desperate cases. Phaco surgeons typically make the transition to MSICS in a relatively short period of time. Experienced phaco surgeons typically require only 10 to 12 cases to learn the MSICS tunnel but they often continue to struggle with the new hydrodynamics of the tunnel for another 20 to 30 cases. The main challenge is the wider tunnel. The inner wall of an 8.0 mm inner tunnel is much more floppy then in the usual 3.0 mm phaco tunnel. Instruments inserted into the anterior chamber must be delicately balanced on the inner posterior lip of the tunnel to maintain the chamber. Manual regulation of the anterior chamber pressure adds a new dynamic to the usual phaco technique not to mention the bimanual technique for cortical management. Additional challenges include absence of a red reflex during capsulotomy and manual expression of the nucleus. These surgeons are often motivated by a desire to help their fellow man. With proper guidance, they can offer appropriate assistance to address the backlog of cases in the fight against global blindness. Transitioning from classic ECCE to MSICS Surgeons trained in classic extracapsular surgery may not have had the benefit of comprehensive ophthalmic training. In addition to the challenges faced by the phaco surgeon, the classic ECCE surgeon must learn the basics of scleral tunnelling and how to handle unfamiliar instruments. Typically, these surgeons require basic instruction in the proper set up of the surgical microscope, hand position and support, how to properly hold blades, the importance of protecting the cornea for improved outcomes, and the concept of bimanual surgery. Good surgeons can achieve basic proficiency with thirty to forty supervised cases. Two hundred fifty to three hundred cases are needed for advanced proficiency and the ability to be a trainer. Classic ECCE surgeons in developing nations see the potential of MSCIS to increase their effectiveness. Their normal ECCE surgery time is often around 30 minutes. Postoperative suture management as well as prolonged healing time make postoperative care a significant burden on their clinical time. While it is possible to significantly improve a surgeon’s classic ECCE technique and reduce time and complications, the one day postoperative results, stability of refraction, and safety cannot match a well done tunnel procedure. Many classic ECCE surgeons have dealt with the nightmare of intraoperative 7 pressure resulting in expulsion and most have experienced postoperative broken sutures with iris prolapse or IOL expulsion. These issues are virtually non-existent with MSICS. Case selection is also broadened with MSCIS. Typically, classic ECCE surgeons have been taught that only the most advanced cataracts have an appropriate risk/benefit ratio. Many 6/60 or counting fingers candidates for cataract surgery are left unoperated until they have deteriorated to perception of light. In fact, the classic ECCE surgeon may be uncomfortable at first with techniques for removal of formed cortex and posterior subcapsular type cataracts. In addition, the classic ECCE surgeon’s paradigm may be more about cataract removal than good one day visual outcomes. Avoiding vitreous loss is the priority, sometimes without practical concern about protecting the cornea. Biometry and IOL calculations are considered to be a luxury rather then a basic necessity. Because of the scarcity of resources, viscoelastics are used sparingly often with serious consequences. The cost of a poor outcome or long recovery is not considered. 8 Chapter 4. Core MSICS knowledge Trainees should demonstrate mastery of the following didactic information. This information should be reviewed as training progresses using case illustrations. The trainer will verify mastery prior to certification of completion of this curriculum. Section 1. Understanding the fundamentals of the MSICS technique Training begins as a carefully guided mental exercise. The trainee must begin to think like an MSCIS surgeon in preparation for hands on training. These principles are best explained by a knowledgeable trainer one-one-one or in a group interactive didactic setting before hands on work in the surgical theater. The principles should be repeated as the trainee progresses. A. Video and live case observation A minimum of 20 live cases will be observed through the teaching scope. In addition, the training video should be reviewed regularly for the first week of training. During observation, the trainer will narrate actions, explaining the specifics of each case in a step-wise fashion. B. Recitation of basic MSICS steps to the trainer The trainee should be able to smoothly verbalize each critical step of the procedure in the proper order. Mentally rehearsing the steps in the procedure helps speed the learning process and reinforces the thought processes needed for good surgical judgement and decision making. Rote learning is typically quite familiar to developing nation trainees and is an important first step to building their confidence. C. Understanding the model using simple line illustrations The trainer will use simple line drawing illustrations to communicate important concepts in MSICS. 1. basic tunnel architecture: note the suspension bridge-like configuration and the limbal straddling 9 2. the tunnel as a flap valve: regulating the anterior chamber pressure 3. the tunnel as a funnel: the only way out of the anterior chamber is the tunnel mouth making it easy to capture the nucleus 4. the inner edge of the posterior tunnel wall as a fulcrum: note the principles of using instruments through a flap valve 5. anterior capsular tearing principles: centripetal vs centrifugal tearing 10 6. nucleus dislocation: cantilever manipulation D. Understanding the difference between a one-handed and a two-handed technique and how this applies to MSICS The trainee will imitate each of the following movements as demonstrated by the trainer. These movements should be practiced at first without a microscope to allow the trainee to get the feel for proper movement of the fingers, wrist, arm, and shoulder. The techniques can then be practiced in a wet lab if available. 1. Making the tunnel The trainee will learn the feel of fingertip control of the blades, use of the fixating hand to move the eye for optimal positioning and the paint brush type stroke used to do the dissection. 2. Holding the cystotome/viscoelastic syringe The trainee will learn to hold the instrument with two hands and will learn the wrist movement needed to pivot the cystotome at a point on the shaft of the cannula. 3. expressing the nucleus: various techniques The trainee will learn to use the lens loop as a glide for the nucleus not a scoop. Maintaining even pressure on the posterior wall of the tunnel when using a curved lens loop will be demonstrated. Demonstration will include the importance of proper wrist action, the use of the fixating hand to roll the eye into optimal position, and various lens loops including the irrigating vectis. The fish hook technique will be demonstrated as an option but this curriculum recommends lens loop removal as the preferred technique. 4. Irrigation/aspiration and cortical manipulation using equatorial sweeping The trainee will learn the hand position needed for rapid manipulation of the syringe as well as finger tip control and wrist position for the cannula. The trainee should practice rapidly switching from irrigation to aspiration and back again. The trainee will practice the pivoting of the cannula between two fingers and sweeping movements while keeping the cannula port upright at all times. The trainee should 11 understand the cannula as a vacuum controlled cortical manipulator rather than simply a device to aspirate cortex. 5. Lens insertion angles The trainee will learn the proper hand, wrist, and arm movements needed to insert both rigid and flexible IOLs. The trainee will understand the proper angle to introduce the IOL into the tunnel, the angle of insertion into the capsular bag, and the rotation of haptics. 6. Viscoelastic as the “third hand” The trainee will understand the concept of supporting the corneal dome, opening the bag, moving the iris or lens, controlling vitreous, and floating a dislocated lens. The rate of injection, the volume, and the use of the anterior chamber itself to direct the movement of viscoelastics will be explained. Section 2. Cataract surgical categories and patient selection Complete diagnostic exam including dilated indirect ophthalmoscope exam is ideal. The reality is that MSICS will often be used in the context of mass screening for surgical case selection. Using clear cornea, the absence of an afferent papillary reflex, and visual acuity of 6/60 to perception of light as the screening criteria, 97% of selected patients will be appropriate surgical cases. Addition of preoperative slit lamp exam to confirm dense cataract, the accuracy increases to 99%. The presence of a dense cataract makes it difficult to rule out pre-existing macular disease that may result in a poor outcome. Evidence of corneal disease, glaucoma, or trauma makes a poor outcome more likely but these patients may still be acceptable candidates for surgery depending on their clinical presentation. Helping the patients understand their situation may be difficult and most are accepting of any improvement. MSCIS surgery is adaptable to a variety of surgical challenges. These challenges are easily categorized and will help the surgeon plan a strategy for each patient. Surgery must always begin with an assessment of surgical category. A. Mature black cataract (HM – LP, red reflex absent) This end stage cataract is often associated with weak zonules, partial dislocation, and pupil abnormalities. Typically, it requires a slightly larger tunnel and sphincterotomy if the pupil is poorly dilated. The capsulotomy must be approached cautiously, taking care to avoid engaging the dense nucleus with the cystotome needle until the anterior capsule is fully open. If the nucleus does not glide easily through the tunnel, enlarge and try again. It is best to minimize the amount of pressure required to express the nucleus. In most cases, there will be minimal residual cortex. 12 B. Mature white cataract (HM – LP, red reflex absent) 1. With nuclear chip A golden color under the capsule should alert the surgeon to the possibility of this condition. It is often associated with capsular fibrosis which may require use of micro scissors for successful cutting and removal. Always begin capsular tear near the tunnel to provide access into the capsular bag in the event of bag collapse. The peripheral bag decompresses rapidly after the first tear of the capsulotomy leaving a golden colored chip that moves freely within the bag. The capsulotomy must proceed with caution keeping the chip under the cystotome needle at all times. The chip must be hydraulically expelled from the bag to prepare for expression of the nucleus. In most cases, the cystotome cannot be used to effectively manipulate the nucleus and only increases the risk of accidental capsular bag tears. There will be minimal residual soft cortex. Occasionally, residual dense cortical debris must be manually expressed from the peripheral bag as it is not soft enough to engage with the Simcoe cannula. 2. Without nuclear chip The hypermature cortical cataract is often associated with capsular fibrosis which may require use of scissors for successful cutting and removal. Always begin the capsular tear superiorly to provide access into the capsular bag from the tunnel if the bag collapses. If the capsular bag decompresses completely after the initial tear, use of the cystotome must stop immediately to avoid accidental tearing of the posterior capsule. Use viscoelastic to reform the bag, to express remaining liquid cortical material, and to clear the view. Enlarge the capsulotomy using capsular forceps or scissors if necessary to create a capsular opening large enough to insert an IOL but do not attempt to complete the capsulotomy until after the IOL has been inserted. A two handed technique may be needed to remove the capsular flap using capsular forceps to stretch the capsule and the micro scissors to cut. If the capsular flap is minimal, the Simcoe cannula may be used to engage the flap and tear it off with a quick jerk. C. Typical advanced cataract (6/60 – CF, red reflex dim but present) Use the standard procedure unless there is associated pathology. Note that rotating the nucleus to dislocate it shears much of the peri-equatorial cortex loose. This cortex may be left behind in the tunnel as the nucleus passes through it and can be easily expressed prior to use of the Simcoe leaving minimal residual cortex. D. Posterior subcapsular cataract (6/36 – CF, red reflex usually present) These cataracts are often associated with younger patients and trauma. A slightly smaller tunnel is adequate for removal of the cataract and will improve control of the anterior chamber. The soft nucleus will make it difficult to manipulate with the cystotome. Anterior capsulotomy must be performed cautiously to avoid pushing the needle through the 13 cataract and the posterior capsule. Hydro dissection of the nucleus is required to luxate the nucleus into the anterior chamber. Expression of as much residual cortex as possible decreases the time needed for manual aspiration. This decreases risk of posterior capsular rupture. E. Juvenile and congenital cataracts The cornea, capsule, and sclera are more elastic if the patient is under 30 years old. For children under ten, the tunnel should be modified to a smaller, squared off configuration approximately 4mm by 4mm. After hydrodissection, I&A is used for removal of the cataract. An alternative is the use of an irrigating cannula sweeping side to side in the tunnel as fluid is injected to wash the cataract out. A foldable acrylic lens should be inserted, if available, with the IOL power modified based on age to allow for normal growth. The following table suggests possible IOL power adjustments needed but final decision should always be on a case by case basis at the surgeons discretion. If biometry is not possible, intraoperative retinoscopy may be used to estimate the IOL power. The aphakic spherical equivalent is multiplied by 1.75 to approximate the IOL power with an A constant of 118.4. The power must be adjusted for other A constants in direct proportion to the difference in the A constant. Age (yrs) 0-1 1-4 5-12 Subtract # of Diopters from IOL power 6 3 1 In patients under 10 years old, primary posterior capsulotomy and mechanical pars plana core vitrectomy are required to avoid secondary cataract formation. This is best performed after the IOL is inserted. These patients are more likely to require suturing and in the case of children under 10, suturing should be done even if the wound is water tight. Section 3. Associated clinical findings requiring technique modifications Always begin the surgical case by inspecting for the conditions described below. Failure to do so will lead to unanticipated complications that may be avoided with planning. A. Small pupil Adequate pupillary dilation is essential using cyclopentolate 2% and phenylephrine 2.5% to assure maximal pharmacologic dilation. Filling the AC with viscoelastic may cause additional mechanical dilation of the pupil. If the pupil did not dilate to at least 7 mm, sphincterotomy should be considered. A straight micro scissor should be used to do at least four 1mm snips evenly distributed around the papillary margin. 14 If the small pupil is associated with posterior synechia, begin with visco/cannula dissection of the synechia to open a space between the capsule and iris. 4 snip sphincterotomy may be used to lyse the fibrotic pupil. Refill with viscoelastic to stretch the pupil open. There should be adequate opening to easily lift the nucleus into the AC. Watch for zonular dehiscence and remember that the synechia may be all that is holding a dislocated lens. B. Zonular dehiscence Depending on the thoroughness of preoperative assessment, a dehiscence may not be identified until the surgeon begins the capsulotomy. If the dehiscence is 4 clock hours or less, use of a PC IOL is possible. Avoid doing capsulotomy in the quadrant of the dehiscence. If the bag is flaccid, attempting to tear it only increases the likelihood of further dehiscence and vitreous loss. To dislocate the nucleus, always push it towards the dehiscence rather then pull away from it. Once the nucleus has been removed, the capsular bag will roll up towards the center of the pupil. Do not attempt to remove cortex from this quadrant and avoid engaging vitreous during aspiration. After removal of cortex from other quadrants, unroll the bag by injecting viscoelastic under the leading edge of the rolled bag. The final position of the IOL haptics should be in the bag in the quadrant of the dehiscence. It is generally best to insert the IOL haptic directly into this quadrant rather then rotating the IOL. If insertion into the bag is not possible, rotate the lens 90 degrees so that the haptics are in the sulcus away from the involved quadrant. If the dehiscence involves more then 4 clock hours, it is best to treat this case as a dislocated lens and insert an anterior chamber lens. Typically these cases are also associated with vitreous loss. C. Dislocated lens Trauma is a common cause of dislocated lens in developing nations probably due to a lack of basic safety training and equipment plus a higher likelihood of personal violence. Homocystinurea and Marfan’s syndrome are also possible causes. Patient histories are often difficult to correlate with findings. The extent of dislocation might not be fully appreciated until the patient is observed under the microscope. Even then, posterior synechial adhesions may mask the full extent of zonular disruption. Attachment of the lens capsule to the iris may act as the support system for the lens. Disruption of the attachments may further dislocate the lens or even result in posterior dislocation. The cystotome can be used to test the stability of the lens by attempting capsulotomy. If tears are not possible, convert to intracapsular extraction. Zonulysin is usually not necessary since the underlying cause is zonular disruption. Expressing the intact capsule through the tunnel may be done with careful pressure on the tunnel and simultaneous 15 injection of viscoelastic underneath the dislocated lens. Generally, a lens loop is required. Rupture of the capsular bag is common during removal. The condition of the vitreous impacts surgical management. Liquid vitreous increases the risk of dropped nucleus but decreases the likelihood of needing vitrectomy. Dense vitreous may act as a pillow to support the lens and remain intact after removal of the lens. If the vitreous face is broken, vitrectomy will most likely be necessary before inserting the anterior chamber IOL. See Section 4 below for description of technique for vitreous removal. 1. Partial dislocation Mechanical zonulolysis of remaining anterior and posterior zonules with a 25 gauge viscoelastic cannula is required. Injecting a small amount of viscoelastic under the lens is helpful to try to float the lens into the anterior chamber as much as possible. If there is no formed vitreous this may require excessive use of viscoelastic and should be avoided. Anterior zonular attachments are broken by sweeping the cannula across the capsule under the pupil. The cannula is then slipped under the lens and, with pressure against the capsule, is swept around the lens lifting it above the iris plane. The lens loop is inserted under the lens for expression in the usual manner. 2. Complete dislocation If the lens is dipping posteriorly, begin by injecting viscoelastic under the lens in hopes of stabilizing or even floating the lens into the anterior chamber. Initial shallowing of anterior chamber may be all that is needed to dislocate the lens into the AC. If not, consider flipping the lens over with the lens loop rather then trying to scoop out the lens. If available, a mechanical pars plana approach to cataract removal should be attempted rather than aggressive attempts to remove the lens with MSICS. 3. Specific considerations for various dislocation orientations Special problems result if a dislocated lens is hinged superiorly. A second instrument must be inserted through the pericentesis to lift the inferior portion of the lens into the AC before a lens loop can be inserted to extract the lens. If the lens is hinged inferiorly, a cannula can usually be passed under the lens while injecting a small bolus of viscoelastic to push vitreous away from the cannula tip. The lens is lifted into the AC for removal. D. Anterior capsular fibrosis A thickened or fibrotic anterior capsule presents a variety of challenges. Small fibrotic bands can usually be broken with the cystotome but broad bands extending to the equator require cutting with micro scissors. Small central fibrotic plaques are easily removed since the capsular bag around it can be torn using the plaque as a sort of template. Capsular forceps are often helpful in managing the fibrotic capsule. 16 E. Advanced pterygium Significant pterygia obscure the view of the anterior chamber making anterior capsulotomy and cortical cleanup more difficult. These patients have a poor prognosis due to distortion of the visual axis even if the pterygium is removed. The risk of recurrence should also be considered. For these reasons, combined pterygia/cataract removal involving the visual axis is indicated only for bilateral blindness. Pterygia outside the visual axis can be removed using the conjunctival peritomy for the cataract operation to free up tissue for a rotational flap. . F. Previous glaucoma surgery or secondary IOL after ECCE A MSICS tunnel can be made through a well healed classic ECCE incision after 6 months. A tunnel procedure should be considered if secondary IOL implantation is planned. The site of previous filtration surgery however, should be avoided. Even a failed bleb site should be avoided as the scleral anatomy is grossly distorted and/or unstable. G. Uncontrolled glaucoma Combined MSICS/trabeculectomy is not discussed in this curriculum. Patients with uncontrolled glaucoma are not likely to achieve the desired outcomes even though in selected cases, a combined procedure should be considered. Section 4. Managing intraoperative complications in a low tech environment Simple, safe, low tech solutions for surgical complications are as important as the MSICS technique itself. All surgeons will experience one or more of these complications and the ability to manage them efficiently reduces stress and improves outcomes. The trainee must have confidence not just in MSICS but also in strategies for managing the following complications. A. Posterior capsular rupture Capsular rupture initiates a cascading series of events that must be appropriately handled to maximize the visual outcome. The first priority is to avoid making the problem worse. All AC irrigation should immediately stop at first suspicion of posterior capsular tear. This allows the surgeon a moment to assess the situation without hydrating the vitreous. The size of the hole, the condition of the remaining capsule, the presence of retained nucleus, the amount of residual cortex, and the condition of the vitreous are all important factors in deciding the next steps. In general, the desired outcome is a PC IOL, round pupil, and no vitreous in the AC. A small amount of retained cortex is acceptable. Use of a standard protocol is helpful to avoid mistakes that may worsen the outcome. Once a hole or tear is identified, all intraocular manipulation 17 should immediately stop. A cohesive viscoelastic should be promptly injected to tamponade the hole. This is accomplished by injecting up into the corneal dome so that a bolus of viscoelastic forms, pushing directly downward and slightly towards the tunnel over the hole. Injecting directly into the hole will only enlarge the opening. The “cohesive” qualities of the viscoelastic (the fact that the bolus holds its shape) make it possible to manage retained nucleus or residual cortex if the bolus is left relatively undisturbed. If vitreous is presenting through the hole, this bolus will help contain the vitreous and push it towards the tunnel for easier cutting. An air bubble can be used if there is not adequate viscoelastic. Dispersive viscoelastics should not be used. The wound is checked for vitreous using a dry sponge or rolled cotton. The sponge is lifted, applying only enough tension to raise the vitreous off the sclera, and any vitreous is cut. If there is a significant amount of residual cortex, this may be safely removed by lowering the irrigation bottle to approximately 40 cm above the patients head and burying the aspiration port in the cortex before aspirating. If the hole is small and/or the anterior capsular rim is intact, consider putting a PC IOL in the capsular bag. If there is a large amount of vitreous or a large hole, intraocular acetycholine or carbachol should be promptly injected to constrict the pupil and help contain the vitreous. Additional viscoelastic is injected into the anterior chamber angle inferiorly to form a bolus that pushes the vitreous towards the tunnel. A sharp Wescott scissor is inserted into the tunnel with the blades open as far as the tunnel allows. A single cut is made with the scissor blades resting on the iris or just slightly behind the pupil. The closed blades are then withdrawn in one smooth motion and any vitreous at the tunnel opening is cut. This action is repeated as needed until the pupil is round. Additional viscoelastic is injected to contain the vitreous behind the pupil and an anterior chamber lens is inserted. The lens should be rotated to the 3 to 9 o’clock position to facilitate iridectomy at the 12 o’clock position. Peripheral iridectomy is difficult to perform through the tunnel. The closed tip of a Colibri forcep is dropped over the central inner edge of the tunnel and the inner tunnel wall is retracted. Midperipheral iris is grasped and lifted. To avoid iridodialysis, the scissor is inserted into the AC to cut the iris rather then attempting to drag the iris out the tunnel. Final wash out of remaining cortex and viscoelastic should be performed with the bottle height no more then 40 cm. The tunnel may require support to close properly after vitrectomy. After a final check for vitreous at the wound, the posterior lip of the external tunnel groove should be grasped and lifted slightly while BSS is injected through the pericentesis. The pressure may rise rapidly and care should be taken to avoid over filling the AC which may result in further vitreous loss. If the chamber does not form, 18 a single 10-0 nylon suture is placed tangentially to the limbus through the anterior and posterior walls of the tunnel. The first triple throw knot is tied with only enough tension to lay it flat on the sclera. 2 additional knots are placed to secure it. B. Tunnel complications Failure to maintain a proper dissection depth is the most common problem: too shallow results in a button hole in the anterior tunnel wall; too deep results in premature entry into the anterior chamber. In either case, immediately withdraw the blade and dissect a new tunnel at the proper depth away from the problem site. In most cases, the case can proceed normally if the problem site is carefully avoided. Premature entry or buttonholing the tunnel are relatively minor complications compared to what happens if these problems are not handled correctly. Premature entry can result in a posteriorly placed tunnel entrance which predisposes to iris prolapse and may not be self-sealing. A button hole may become a scleral flap if it extends. A leaking tunnel after uncomplicated surgery is rare but if it occurs, use a single 10-0 nylon placed tangential to limbus. The suture supports the posterior wall of the tunnel, improving the chance for proper apposition. Scleral perforation while making the groove or tunnel must be repaired using 8-0 vicryl to close the gap. Amputations of the external tunnel wall can be repaired by repositioning the free flap and suturing with 10-0 nylon. Cutting one or both ends of the inner tunnel wall is repaired using tangential 10-0 nylon passed through the end of the tunnel through the free flap edge. C. Flat chamber The development of a rock hard eye and flat chamber during MSICS requires prompt intervention. In most cases this is a result of aqueous misdirection. A 21 gauge needle on a 3 or 5 cc syringe is passed through the pars plana (approximately 2.5mm to 3.0 mm posterior to the limbus). The needle is directed towards the center of the eye and liquefied vitreous is aspirated until the pressure is normalized. The needle is withdrawn and the case is finished if possible. In general, if the chamber cannot be maintained, it is better to leave cortex then to risk trauma to corneal endothelium. Infiltrate the paracentesis site with BSS to seal the cornea. If the pressure is still low, grab the posterior external tunnel lip and lift while injecting BSS through paracentesis. If unsuccessful, tangential tunnel suture with 10-0 nylon may be necessary. 19 D. Iris prolapse This complication is generally due to a poorly constructed tunnel, usually a posteriorly displaced inner tunnel entrance. (See “tunnel complications” above for how to avoid worsening a premature entry.) Pressure in the AC causes the prolapse almost immediately after the tunnel is made. Repeat efforts to reposition the iris only results in loss of iris pigment and shredding of the iris tissue. By carefully working over the iris tissue, the case may be completed with minimal additional trauma to the iris. After the IOL is in position and viscoelastic has been removed, the iris is then repositioned by lowering the AC pressure and sweeping the iris in with the Simcoe cannula (no fluid running). The AC is slowly deepened by injecting BSS through the paracentesis taking care to avoid overfilling the AC. If necessary, the superior iris is swept out of the tunnel using the cannula through the paracentesis. E. Iridodialysis Iridodialysis is usually caused by poor technique with the lens loop. If the iris is pinched between the loop and the nucleus at 12 o’clock, a superior dialysis occurs as the lens loop is inserted. If the iris is pinched between the lens loop and the nucleus at 6 o’clock, a dialysis occurs inferiorly as the lens loop is removed. Carefully floating the nucleus into the tunnel prior to insertion of the lens loop helps prevent superior dialysis. Passing the lens loop no more the two-thirds of the way across the nucleus helps prevent the inferior dialysis. If a superior dialysis results in a hammock pupil blocking the visual axis, iris suturing should be considered if appropriate sutures are available and the surgeon has been trained in proper techniques. If not, consider transecting the iris to make a keyhole pupil. F. The dropped nucleus Begin with a manual core vitrectomy and attempt to float the nucleus up by allowing the anterior chamber to flatten. Irrigation of BSS or viscoelastic may be used to float the nucleus into the AC. If unsuccessful, it is best to leave the nucleus in the posterior segment and restrict the patient to rest with the head elevated for at least one week in the hopes that the nucleus will not damage the macula or cause retinal detachment. Section 5. Understanding the management of postoperative complications In general, postoperative complications are the same as in any anterior segment surgery. Keep in mind that the tunnel can be easily opened with blunt dissection for more than two weeks postoperatively. It may be difficult to locate the original paracentesis. 20 A. High IOP with normal anterior chamber Treat with acetazolmide 500 mg plus timolol 0.5% or paracentesis if the IOP is > 50mm and does not respond to medications within 2 hours. B. Flat or shallow chamber with low IOP Assume there is a wound leak and return to surgery for suturing. C. Flat or shallow chamber with high IOP The diagnosis is papillary block and laser or surgical iridectomy is indicated as soon as possible D. Hyphema The hyphema will likely clear on its own. Increase topical steroids and observe. If there is evidence of corneal blood staining, then wash out is indicated. E. Stromal edema- focal Increase topical steroids. Always look for patterns that may suggest the need for changes in technique. F. Stromal edema- diffuse Increase topical steroids. Check for appropriateness of consumables used intraocularly and review daily patterns. This may represent toxicity from improper irrigating solutions, improper rinsing after alternative sterilization techniques using acetone or chlorhexidine, or prolonged surgery. G. Microcystic edema Check the IOP and treat if elevated. Artificial tears may be added for comfort. H. Dislocated IOL: If affecting vision, return to the operating theatre to reposition or replace with an AC IOL. I. Endophthalmitis protocol If the patient presents with pain and significant inflammation between day one and ten, the most likely diagnosis is endophthalmitis. The following treatment protocol provides the best chance of recovery. If the eye has lost all vision, palliative treatment is still indicated even if enucleation is being considered. 21 CEFTAZIDIME (vial of 1000mg in powder form) Step one: Inject 4.4 mL of sterile saline to 1000mg vial. Dissolve. Step two: draw 0.1 mL of this solution in a 1 mL syringe. Step three: Replace the needle with a new empty needle, and draw 0.9 mL of sterile saline to make 1 mL. Step four: Discard all but 0.1 mL containing 2.25mg of Ceftazidime. Ready for intravitreal injection PLUS VANCOMYCIN ( vial of 1000 mg in powder form) Step one: Inject 10 mL of sterile saline to this vial with 1000 mg of Vancomycin. Dissolve. Step two: Draw 0.1 mL of this solution into a 1 mL syringe. Step three: Using a new needle draw 0.9 mL of sterile saline to make 1mL. Step Four: Discard all but 0.1 mL of this solution containing 1mg of Vancomycin, ready for intravitreal injection. 22 Chapter 5. Core MSICS surgical skillsTrainees should demonstrate mastery of the following skills. The trainer will verify mastery prior to certification of completion of this curriculum. A. Surgical fundamentals 1. Microscope, surgeon, and patient positioning 2. Proper technique for holding blades- the paint brush technique, proper finger tip control 3. Proper hand support 4. Holding the Simcoe cannula 5. Two-handed technique B. Anesthesia options and management of complications 1. Deep or equatorial peribulbar, subtenons, anterior conal and posterior conal retrobulbar, topical 2. Anesthetic considerations: volume and type of anesthetics 3. Management of complications including retrobulbar hemorrhage, seizures, respiratory arrest, circulatory collapse, and globe perforation C. Sclero-corneal tunnelling: the mechanics of slicing 1. Using the crescent blade like a paint brush 2. Groove- demonstrate various techniques 3. Tunnel- demonstrate various techniques 4. Keratome entry- demonstrate various techniques D. Capsular manipulation- the mechanics of tearing 1. Demonstrate can opener technique- cystotome pulled towards the center creates capsular tears towards the center. Approximately 35 cuts produces near capsulorhexis quality 2. Demonstrate various capsulorhexis techniques- If the red reflex is present, convert can opener technique to continuous tear. With practice, this can be done even without red reflex. Trypan blue may be used for training purposes to visualize the capsule better. 3. Demonstrate scissors capsulotomy for fibrous capsules E. Nucleus manipulation- the mechanics of rotation, expression, and sliding 1. Demonstrate the use of nucleus rotation to produce a shearing plane between nucleus and cortex 23 2. Demonstrate the even distribution of forces on the zonules produced by rotation 2. Demonstrate expression of material from the capsular bag like water from a surgical glove with a hole in it 3. Demonstrate the funnel effect of the tunnel, driving the nucleus into the tunnel with irrigation and pressure on the inner wall of tunnel 4. Demonstrate the use of the lens loop as a glide by applying pressure to the inner wall of the tunnel. 5. Demonstrate proper technique to protect the endothelium F. Cortical manipulation- the mechanics of shearing and aspiration 1. Demonstrate use of the Simcoe to engage and manipulate cortex using vacuum as a tool for grasping the cortex 2. Demonstrate efficient manipulation of the cortex using sweeping movements to engage the equatorial cortex. 2. Demonstrate efficient cortical drag and drop technique using the tunnel as a funnel for hydroexpression 3. Demonstrate proper Simcoe technique to maintain the chamber by keeping aspiration port up and using the inner tunnel opening as a fulcrum G. Management of co-morbidities and complications 1. Practice the posterior capsular tear drill with and without vitreous loss 2. Practice tangential tunnel suturing technique for leaking tunnel closure 3. Practice button hole tunnel recovery technique 4. Practice premature entry recovery technique 5. Practice scissors sphincterotomy 6. Practice visco dissection and hydro dissection 7. Practice various strategies for removal of residual formed cortex using paracentesis and various cannulas 8. Practice various techniques for managing the prolapsed iris 24 Chapter 6. Using MSICS as a stimulus for development of the ophthalmic community From the beginning, the trainee should understand that the transition to MSCIS provides them an opportunity to promote change. A MSICS certificate is just another certificate on the wall if there is no challenge to seize the opportunity for development of their own institutional systems. Lasting changes will not come from governments or outside agencies. At best, these institutions can and should be supportive. Ultimately, the changes must come from those who are providing the service. A comprehensive plan for leadership development is beyond the scope of this curriculum but the trainee should demonstrate familiarity with at least these principles. Section 1. Developing the disciplines needed for success In the context of developing nations, success may be as unfamiliar as MSICS. Tolerance of the status quo is expected and turf and position are jealously guarded. The trainee must develop the mental skills and disciplines needed for success in this context. The mentoring relationship is vital for communicating these principles and encouraging the trainee to persevere. A. An orientation towards team building Team building promotes the concepts of unity, mutual respect, human value, individuality, and the willingness to share information for the greater good, all of which are crucial for the development of a functioning system. As trust develops, the team becomes more efficient and adaptable to the many challenges it will face to keep up high quality, high volume service. Work becomes more energized when there is a sense of team. The key team building “technique” in developing nations, is communicating respect. Including the other team members in problem solving discussions, team meetings prior to beginning each day so that all are aware of the goals for the day, recognition of individual accomplishment, and brief team meetings to communicate important information all communicate respect. Voluntary team bible study is effective for promoting unity and joyfulness. Team building does not guarantee success but success is not possible without it. B. An orientation towards positive goal setting and continuing education Positive goal setting promotes the concept of incremental change and the pursuit of excellence. By setting positive goals the trainee learns the simple but profound principle that success is moving towards what is good not just moving away from what is bad. This orientation is needed to overcome the fatalistic mentality that often hinders the pursuit of quality and long term success. Appropriate continuing 25 education must become a routine for the trainee. The trainee and their team must understand that the goal is not just removal of a cataract, it is restoring the sight of an individual. C. An orientation towards compassionate action Compassion is important for team success because it encourages the self-sacrifice needed to serve the vulnerable without exploitation or corruption. Positive goals set the direction, but compassion is the motivation the team needs to move forward. Monetary reward is seldom sufficient for long term commitment to a goal. Those who are motivated primarily by their pay checks or status will likely be unproductive team members. D. An orientation towards focused action It is often said that if you are aiming at nothing you can hit it every time. Intentionality rather then serendipity is a key strategy for success. Many developing nations have learned to simply wait for outside help to come to their rescue. Focused action is needed to pursue opportunities and, at the end of the day, to accept genuine accountability for achieving what was intended. It teaches the value of perseverance but also letting go when something is not working. The trainee who is focused on the task of building a successful system will avoid distractions and over commitment. E. An orientation towards prayerful action Surgery offered as a prayer puts the surgeon and the team in exactly the right frame of mind for a success. Most people in developing nations embrace the spiritual as a normal part of life. To ignore this because of western secularism misses an important opportunity to reinforce a proper attitude towards healing. We must all be reminded that successful results sometimes are more about spiritual realities then about the surgeon’s knife or technique. Prayer is a reminder of the dangers of pride and the reality of grace for the humble. A brief group prayer at the beginning of each day is a simple way to raise awareness of this principle. Section 2. The vision restoration paradigm The transition to MSCIS should be used to challenge the trainee’s cataract surgery paradigm. It must be clear that this curriculum is not just conveying a skill, it is also promoting a new system for success in their professional life. A. A patient-oriented understanding of successful cataract surgery As the trainee comes to understand the quality that is possible with MSICS, their concept of success should be challenged. Success should not be judged 26 by absence of operative complications or even number of operations. Success should be defined by the patient experience and their perceptions. Uncorrected vision and comfort are the patients’ measure of success. And the first or second postoperative day is often when the patient and their family decide if their money was well spent. Surgeons who understand this concept will develop the appropriate service orientation for success. B. Importance of biometry and IOL power selection For optimal uncorrected vision, proper IOL selection is critical. If standardized IOL power is used, a perfect procedure may produce suboptimal results and patient dissatisfaction. Surgeons should be familiar with how to do biometry even though they may utilize their staff to do the measurements. Maintaining a reasonable inventory of IOLs is critical to make full use of biometry. C. Understanding the importance of auditing outcomes A surgeon who is committed to patient success must learn how to audit their own outcomes. There are several strategies and templates available separately from this curriculum. See http://www.cehjournal.org/files/globalreview/globalreview_024.pdf . Audits of postoperative outcomes provide the data to identify opportunity for system improvements. Section 3. Facilitating a successful local cataract project The trainee must learn how to develop their own institution as a platform for successful cataract surgery. To begin this work, the trainer must be able to confirm the quality of the trainee’s performance. The staff and administration must know that the stage is set to try something new and exciting that will benefit their reputation and their institution. If the trainee is not ready, it is best not to start this process and surgical training should continue. If it is determined that the surgeon is not a candidate for a successful project, it is best to move on to other trainees. A. Assess local conditions, equipment, consumables, and staff Develop a comprehensive assessment plan with the trainee. Where will there likely be problems? Can any training be done to assist with these problems? Is additional equipment needed? Where will the first patients come from? Is the institution willing to back the start up efforts by offering free use of facilities? B. Prepare the local team The surgeon must be prepared to be the leader of the team. This may require involvement with details not normally part of the surgeon’s tasks. Make sure 27 each team member knows what is going to happen and how their job contributes to the success of the team. C. Address political barriers Most institutions have barriers designed to prevent change. The trainer can act as an advocate for the team to address these barriers. And once the team has proven itself, administrators may continue to provide support. Interference from peers or other medical professionals is common. A willingness to promote their success will go a long way towards overcoming their resistance. Section 4. Foundations for developing the local eye care industry MSCIS can be used to drive development of the local eye care industry. Once a local team has been successful, doors may begin to open for broader support and corporate sponsorship. Rather then propping up or trying to improve old systems, the trainee must learn to challenge existing practices and systems that may be preventing development of sustainable solutions to treatable blindness. A grasp of the basics economic issues of cataract surgery care will help the trainee maximize the financial benefit. A. The basic economics of MSICS: the value of time and satisfaction ↓ surgical time = lower cost/case ↓ postop problems = lower cost/case ↑ patient satisfaction = decreased opportunity cost as patient demand increases ↑ surgeon satisfaction = decreased recruiting and retention costs as surgeons develop confidence and improved financial return B. Understanding fixed and variable costs/case The variable cost of consumables is about the same as classic extracapsular surgery. MSCIS is not about drastically reducing the cost of surgical supplies. It decreases cost by increasing productivity and reducing complications. The highest fixed cost is in personnel. The most effective way to decrease cost per case is by increasing productivity. BUT this must be accompanied by a higher level of team satisfaction to be accepted. 28 C. Quality in cataract surgery drives ophthalmic industry development Elective surgery in an older population must be high quality to be successful. The eye care industry in any nation is built on the success of cataract surgery because this is ophthalmic service with the highest perceived value. Management of glaucoma, corneal, and vitreoretinal disease are important but must be built on the foundation of a successful cataract center. 29 Chapter 7. Training surgeons to train others It should first be said that not all surgeons will make good trainers. Even the most proficient surgeons sometimes lack the attitudes and skills needed to assist others through the tedious learning process. The trainer should make sure the trainee has the aptitudes and desire to be a trainer by observing how they interact with others. Those who are naturally teachers are usually the best candidates. Training a surgeon to be a trainer begins with raising awareness of HOW the training process occurs. Hopefully, the trainee will be able to use their own training experience as a positive model but they will require help separating training skills from their surgical skills. One of the main problems a trainer faces is establishing an effective training connection with the trainee. It takes time for this connection to develop. Everyone learns a little differently and the most effective trainers are those who know how to identify and use those differences to establish a connection. Cross-cultural issues and previous bad educational experiences may have a negative impact on the trainee. Training a trainer requires helping them overcome their own challenges before they can help others. It may be difficult for a new trainer to allow room for mistakes, let alone provide guidance on how to address the mistakes while staying positive and respectful. It is easy to take over too soon if a case becomes difficult. The patience required may not come naturally to some. A. Using the “Head, Hands, Heart” surgical training concept This curriculum is designed to be transferable. It is built around the idea that good surgeons require a good head, good hands, and a good heart to be successful. This training is designed to address all three areas in that specific order. The new trainer should learn this curriculum in detail. Over time, their own experiences will add the needed depth and conviction. The new trainer should be reminded that it is appropriate to be selective in choosing their trainees and that the process of training may be spread out over a longer period of time then their own training. Emphasize the importance of both surgical concept and technical patterns: both the “what” and the “why”. Begin development of fine motor skills early and address bad technique directly and immediately. Try to avoid letting bad habits get started. Learn to read a trainees level of stress. When stress is high, learning will decrease. Try to select training cases where success is likely. There is very little to be learned from painfully enduring a long, hard case. It is better for the trainer to take over when the learning value of a case decreases or a patient’s outcome is in jeopardy. B. Communication tips Remember that as the trainer, you must know what you are trying to say and why. Stay purposeful but do not be afraid to be repetitive. In general, it is helpful to focus on one element of technique at a time. Learning will progress more 30 rapidly if the message is communicated in small bites rather then a deluge of information or criticism. Always communicate respect and the importance of the trainee’s success. Learning increases as confidence builds but false confidence and empty praise can be destructive. Make sure communication is always two-way. A trainee may be able to explain what they need if you are listening. It is helpful to be able to record trainee surgery to allow for step by step discussion of technique and to document progress. Recordings also help a trainee learn to critique their own technique. Concepts must be taught from a variety of angles. Overviews, short talks, drawings, videos, and live demonstrations must all be used. Remember that the trainer is teaching attitudes as well as facts. Often these attitudes are caught rather then taught. As the trainer, you must demonstrate the value of patients and your team. Final note: The importance of surgeon advocacy Raising awareness of the tragedy of unnecessary blindness is critical. The 30+ million who could have their blindness corrected need a voice to make their needs known. But those surgeons who, in the end, are responsible for addressing that need must have a voice as well. In developing nations, surgeons do not enjoy the prominence or incomes that are common in the west. To be sure, there are unscrupulous surgeons in developing nations just like anywhere else. But my hope is that this curriculum is in the hands of those who will make the most of it for the sake of the blind. Developing nations are waiting for their own “beloved physicians” who are willing to say “this is no longer acceptable.” Being an advocate for these physicians may be one of the most important things we can do. One final thought: It is my personal conviction and observation that it is not enough to hate blindness and the poverty that is at the heart of the problem. There seems to be no end to human suffering and it is easy to be overwhelmed with the need. May I suggest that these needs point us towards profound realities about our world and our selves, a constant reminder of how small I am and how, in the end, there must be another solution outside of me to end this tragedy. I must hold on to a belief that there is a loving God who values every life and asks us to love as He loves. There is no higher achievement then giving honor to the One who is the source of all life and well-being. Only this is enough to sustain me in the work. Glenn Strauss, M.D. 2010 31