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Chemical and biological studies on some
Heterocyclic nitrogen derivatives
presented by
Nahla abd elmoaty mohamed
(M.Sc., Organic Chemistry)
For Partial Fulfillment
of The Requirements of The
Doctorate in philosophy of science
3
Introduction
Nitrogen containing heterocyclic compounds have received
much attention as it posses exciting biological activities such as
antimicrobial, anticonvulsant, cardiotonic, antifungal,
anticancer, antitumor agent, and anti‐inflammatory
activities so they are considered as important key elements.
The phthalazine derivative azelastine (A) is an antihistamine
used in the treatment of allergic rhinitis.
Cl
N
N
N
O
A
Me
Zopolrestat (B) is aphthalazinone derivative that has been in 
clinical trials , it inhibit aldose reductase and has potential use
in the prevention of retinopathy,neuropathy, and
cataractformation in diabetes
CF3
CO2H
N
N
N
O
S
B
The chemiluminescence reaction of luminol (C) has found
analytical application, paticularly in biological system.
NH2
OH
N
NH
O
C

Aim of work
Synthesis of some
heterocyclic nitrogen
derivatives with potential
biological activity.
Plan of work
1-Synthesis of some heterocyclic nitrogen compounds.
2-Studying the behavior of the synthesized compounds
towards organic reagents.
3-Elucidation the structures of the synthesized compounds via
chemical methods and spectroscopic methods {IR, NMR,
Mass, etc}.
4-Studying the biological activity of the synthesized
compounds towards some microorganisms such as bacteria
and fungi.