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Systems Engineering Research and the Cancer Care Engineering Project Joseph F. Pekny, Ph. D. (Purdue University) Professor of Chemical Engineering Interim Head of Industrial Engineering Cancer Care Engineering Project Leads: Pat Loehrer, MD Kenneth Wiseman Professor of Medicine Director, IU Simon Cancer Center Associate Dean of Cancer Research Indiana University School of Medicine Joe Pekny, PhD Professor of Chemical Engineering Interim Department Chair, Industrial Engineering Founder, Regenstrief Center for Healthcare Engineering Purdue University Marietta Harrison, PhD Professor of Medicinal Chemistry Associate Vice President for Research Director, Oncological Sciences Center Purdue University Notre Dame Joins CCE Project Funding • U.S. Army Medical and Materiel Command – $2.3M – Negotiating additional award • Regenstrief Foundation – $1.35M • Walther Cancer Foundation – $1.8M • NIH (2) and DoD (1) pending Opportunity: Further Systematizing Cancer Care Innovation Thousands of Journal Articles, Best Practices, Landmark Studies, Rapid IT Advances, Large Amounts of Data, Systems Biology, Golden Age of Life Science Breakthrough Cures, Uneven Care, “Miracle” Patients, Policy Needs, Ongoing Opportunity for Reality to Research and Back Cancer Care Engineering Science & Technology Cancer Care Practice “We want to know with certainty whether the treatment protocol for a young, non-smoking mother of 3 with colon cancer will work. Today we can only tell her in terms of percentages the potential treatment effectiveness. The monthly cost is in the tens of thousands and may not be effective for her. We order it and hope.” Goal • Needs Better Tool Now • Needs Way to Rapidly Improve Tools Going Forward by Applying More, Advancing, and Targeting Science and Technology CCE Summary: Processing Samples, in Position to Develop First Generation Pilot Tools CCE Component in Progress Prevention & Treatment: Sample Acquisition & Analysis (Colorectal Cancer): Patient Subgroups Personalizing Cancer Care: The Importance of Patient Groups Clinical Trials Phase I Phase II Clinical Trials Phase III Phase I Phase II Phase III On which patient groups does Drug X work? Patient groups are indistinguishable with respect to treatment Clinical Trials Phase What I Clinical TrialsDrug Phase I Phase II Phase isPhase dosage best? II III X Phase III Clinical Trials Phase I Phase II Phase III
