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SURVIVAL ANALYSIS OF BREAST CANCER PATIENTS TREATED AT A TERTIARY CARE CENTRE IN SOUTHERN INDIA ESMO CONGRESS 2014, MADRID, SPAIN European Society for Medical Oncology Dr.RajkumarArumugham, Dr.Arulraj, Dr.M.Nagarajan, Dr.Janardhan Yerram Shetty, R.Vijayalakshmi AIM : To analyze the 5 year survival of breast cancer patients treated at a tertiary care center in Southern India and the impact of various prognostic factors including age, luminal subtypes and stage on survival. METHODS : This is a retrospective study of 324 patients with breast cancer treated at a tertiary care center in southern India in the years 2008 – 2009 with a follow up for 5 years. Case records of these patients were analysed for baseline characteristic including receptor status and other prognostic factors, treatment given and survival. Overall survival curves were estimated using Kplan Meier method. A multivariate analysis and log rank test was done to analyze the interaction of various prognostic factors and survival. RESULTS : A total of 324 patients were included in the analysis. Among these patients 60% had early breast cancer (Stage I & II), 24 % locally advanced and 4% metastatic disease at presentation. A relatively high incidence of triple negative cancers was seen (24%) while her 2 positive disease was seen only in 8%. The 5 year overall survival stage I patients was 95%, stage II was 92%, stage III was 70% and stage IV 21%. Her 2 positive patients with early breast cancer fared significantly worser when compared to luminal types (74% for Her 2 type, 77% for TNBC, 90% for luminal A and 99 % for luminal B cancers. CONCLUSION : Survival data on breast cancer patients in developing countries like India is largely lacking in the literature. Previously reported data from a few tertiary care centers mostly in northern and western parts of India revealed a relatively poorer prognosis stage wise compared to western literature. India is a vast country with differing cultures, food habits and a varied population. The inherent biology of the disease, stage at presentation and response to treatment is likely to differ within different parts of the country. Thisstudy is one of the few that provide data on the survival patterns of breast cancer patients in Southern India. Our study revealed that a substantial number of patients present with early disease and they have a good survival on par with western literature. The shift to earlier stages of presentation with consequent better survival could be due to increasing awareness of the disease, higher literacy rates in this part in this part of the country, availability of specialized treatment centers and better socio economic conditions. Charts Survival – Receptor wise Kaplan Meier Analysis Survival – stage wise Code Code Number at risk 100 Time Time 100 Group: I 32 90 31 29 8 0 35 0 95 80 157 Stage I II III IV 70 60 50 40 146 130 Group: III 75 59 43 13 0 Group: IV 20 6 3 0 0 Survival probability (%) Survival probability (%) Group: II 90 IHC Her 2 type Luminal A Luminal B TNBC 85 80 75 30 70 20 0 20 40 (Months) 60 80 0 20 40 (Months) 60 80 Number at risk Group: Her 2 type 23 Group: Luminal A 157 Group: Luminal B 12 Group: TNBC 75 18 15 2 0 139 125 42 0 12 11 1 0 59 47 11 0