Download survival analysis of breast cancer patients treated at a tertiary care

SURVIVAL ANALYSIS OF BREAST CANCER PATIENTS TREATED AT A TERTIARY CARE CENTRE IN SOUTHERN INDIA
ESMO CONGRESS 2014, MADRID, SPAIN
European Society for Medical Oncology
Dr.RajkumarArumugham, Dr.Arulraj, Dr.M.Nagarajan, Dr.Janardhan Yerram Shetty, R.Vijayalakshmi
AIM : To analyze the 5 year survival of breast cancer patients treated at a tertiary care center in Southern India and the impact of various prognostic factors including age, luminal subtypes and stage on
survival.
METHODS : This is a retrospective study of 324 patients with breast cancer treated at a tertiary care center in southern India in the years 2008 – 2009 with a follow up for 5 years. Case records of these
patients were analysed for baseline characteristic including receptor status and other prognostic factors, treatment given and survival. Overall survival curves were estimated using Kplan Meier method. A
multivariate analysis and log rank test was done to analyze the interaction of various prognostic factors and survival.
RESULTS : A total of 324 patients were included in the analysis. Among these patients 60% had early breast cancer (Stage I & II), 24 % locally advanced and 4% metastatic disease at presentation. A relatively
high incidence of triple negative cancers was seen (24%) while her 2 positive disease was seen only in 8%. The 5 year overall survival stage I patients was 95%, stage II was 92%, stage III was 70% and stage IV
21%. Her 2 positive patients with early breast cancer fared significantly worser when compared to luminal types (74% for Her 2 type, 77% for TNBC, 90% for luminal A and 99 % for luminal B cancers.
CONCLUSION : Survival data on breast cancer patients in developing countries like India is largely lacking in the literature. Previously reported data from a few tertiary care centers mostly in northern and
western parts of India revealed a relatively poorer prognosis stage wise compared to western literature. India is a vast country with differing cultures, food habits and a varied population. The inherent
biology of the disease, stage at presentation and response to treatment is likely to differ within different parts of the country. Thisstudy is one of the few that provide data on the survival patterns of breast
cancer patients in Southern India. Our study revealed that a substantial number of patients present with early disease and they have a good survival on par with western literature. The shift to earlier stages
of presentation with consequent better survival could be due to increasing awareness of the disease, higher literacy rates in this part in this part of the country, availability of specialized treatment centers
and better socio economic conditions.
Charts
Survival – Receptor wise
Kaplan Meier Analysis Survival – stage wise
Code
Code
Number at risk
100
Time
Time
100
Group: I
32
90
31
29
8
0
35
0
95
80
157
Stage
I
II
III
IV
70
60
50
40
146 130
Group: III
75
59
43
13
0
Group: IV
20
6
3
0
0
Survival probability (%)
Survival probability (%)
Group: II
90
IHC
Her 2 type
Luminal A
Luminal B
TNBC
85
80
75
30
70
20
0
20
40
(Months)
60
80
0
20
40 (Months)
60
80
Number at risk
Group: Her 2 type
23
Group: Luminal A
157
Group: Luminal B
12
Group: TNBC
75
18
15
2
0
139
125
42
0
12
11
1
0
59
47
11
0