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Principal Investigator/Program Director (Last, First, Middle):
Gueron, Geraldine
BIOGRAPHICAL SKETCH
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NAME
Geraldine Gueron
eRA COMMONS USER NAME
POSITION TITLE
Assistant Researcher
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as
nursing, and include postdoctoral training.)
DEGREE
INSTITUTION AND LOCATION
(if
YEAR(s)
FIELD OF STUDY
applicable)
University of Buenos Aires, School of Sciences,
MSc
2003
Molecular Biology
Buenos Aires, Argentina
University of Buenos Aires, School of Sciences,
PhD
2009
Biological Chemistry
Buenos Aires, Argentina
A. Personal Statement
My main research focus is on studying the molecular pathways involved in the pathogenesis of prostate
cancer and its subsequent progression. Specially those signaling cascades that govern the inflammatory
milieu leading to malignant prostate transformation. The ability to orchestrate cytokines, chemokines and
their receptors, trigger oxidative/nitrosative stress and favor antioxidant imbalance prompts a proinflammatory scenario, that alters and recruits host inflammatory and stem cells, contributing to the
survival and expansion of prostate tumors. The principal goal currently within PCa research is to unveil
markers for early detection of aggressive tumors that are predestined to invade and metastasize and then
to design better option treatments for those patients with aggressive PCa. Bone metastasis diagnosis and
treatment still remains a critical aspect of PCa biomarker research. In this context, the use and
implementation of high-throughput and proteomic technologies for tissue biomarker research is facilitating
a more personalized approach for disease early detection and treatment. The key relies in that
breakthroughs made by the field of proteomics move fast enough from biomarker discovery to thorough
validation and application of the findings in clinical trials. Analysis of the tissue may be able to provide a
clearer perspective of the molecular topography of the PCa tumor. Considering the heterogeneity of PCa,
it is unlikely that a single marker is enough to discriminate between stages of disease and track the
efficacy of treatments. For these reasons a stroma–epithelium signature constituted by a set of markers
that come from different cellular compartments could provide a better means to diagnose and manage
PCa patients. The goals of my studies are to decipher the molecular signatures associated to the
progression of prostate cancer through a proteomic and bioinformatics approach and the use of tissue
microarrays, with continuing emphasis on translating these results into providing novel biomarkers to
serve as prognostic/diagnostic factors for PCa.
B. Positions and Honors.
Positions and employment
2000-2003
Research fellow, Laboratory of Organic Synthesis. Department of Organic Chemistry,
School of Sciences, University of Buenos Aires, Buenos Aires, Argentina. Studies on
Organic Synthesis. Topic: Transformation of functional groups on synthetic polymers
and monomer synthesis for polimerisation. Unpublished papers: “Modifications of
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Principal Investigator/Program Director (Last, First, Middle):
Gueron, Geraldine
polyacrilonitrile by 1,3-dipolar cycloaddition”(Geraldine Gueron, Miriam A. Martins
Alho, and Norma B. D’Accorso).
2003 - 2004 Research fellow, Laboratory of Inflammation and Cancer, Department of Biological
Chemistry, School of Sciences, University of Buenos Aires, Buenos Aires, Argentina ).
Topic: oxidative stress and its relationship with inflammatory processes and prostate
cancer. Balance between cell proliferation and apoptosis and HO-1 response.
2006
Research fellow. Cell membrane Biology Laboratory. Biochemistry Department.
Institute of Molecular and Cellular Biology. University of Leeds. Supervisors: Prof. E.J.
Wood (M.A-PhD) and Prof. Anthony Turner (M.A-PhD) Dean of Faculty of Biological
Sciences, University of Leeds, United Kigdom.
2006 - 2009 Research fellow. CONICET (National Council of Education, Technology and Scientific
Research.) Department of Biological Chemistry, School of Sciences, University of
Buenos Aires, Buenos Aires Argentina Supervisor: Elba Vazquez (PhD). Topic: Heme
oxygenase-1 and Inflammation in Prostate Cancer.
2008
Teaching position for the Molecular Oncology Module of the Masters in Molecular
Biology, School of Sciences, University of Buenos Aires.
2008-present Teaching position for the Postgraduate module: “Apoptosis and Cancer: Cellular and
molecular approaches” Dept. Biological Chemistry. School of Sciences, University of
Buenos Aires.
2010-2012
Postdoctoral Research fellow. IQUIBICEN-CONICET, School of Sciences, University
of Buenos Aires.
Other Experience and Professional Memberships
2005-2006
Member: Biochemical Society, United Kingdom.
2008-present Member, American Association for Cancer Research (AACR)
2009-present Member, Women in Cancer Research (WICR)
2011-present Member, Argentine Society of Clinical Investigation (SAIC)
2011-2014
Member, Associate member Council (AMC) American Association for Cancer
Research (AACR)
Honors
2005-2009
2005-2006
2006
2007
Postgraduate scholarship granted by CONICET–(National Council of Education,
Technology and Scientific Research.
Postgraduate Research Scholarship granted by ALßAN for period 2005-2006 at University
of Leeds, United Kingdom
Member of the Biochemical Society, United Kingdom.
Prize granted by “The 5th International Heme Oxygenases Conference”, Krakow, Poland,
September 3rd -10th 2007.
2008
Prize “FARYNA” granted by the Argentine Society of Clinical Investigation (SAIC) to the
“best work in Oncology presented by a PhD student”, Mar del Plata City, Argentina (1923th November).
2009
Prize “AACR-Prostate Cancer Recognition Award” presented to young cancer researchers
who are the first authors and presenters of highly rated proffered papers focused on
advanced/late stage prostate cancer research. Granted by the Prostate Cancer
Foundation. AACR annual meeting 2009, Denver, Colorado, USA (18-22th April).
2010
Prize “AACR-AstraZeneca International Scholar-in-Training Award” granted by the
American Association for Cancer Research” AACR annual meeting 2009, Washington,
USA (17-21st April).
2010
Post-Doctoral scholarship granted by the CONICET – (National Council of Education,
Technology and Scientific Research)
2012
Postgraduate Fellowship granted by Bunge y Born Foundation
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Principal Investigator/Program Director (Last, First, Middle):
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Gueron, Geraldine
2012
2nd Prize “Young investigator Plenary Session” at the Heme-oxygenases and related
enzymes conference, Edinburgh, Scotland, May 28th-June 2nd 2012
2013
Prize “Scholar-in-Training Award supported by Aflac, Inc. granted by AACR. Ninth AACRJapanese Cancer Association Joint Conference: Breakthroughs in Basic and Translational
Cancer Research MAUI, HI,USA (21-25th February).
2013
Prostate Cancer Foundation Young Investigator Award (PCF- April 2013)
Peer-reviewed publications
1) Ge Y, Byun J, De Luca P, Gueron G, Yabe I, Sadiq-Ali S, Figg W, Quintero J, Haggerty C, Li Q, De Siervi
A, Gardner K. “Combinatorial antileukemic disruption of oxidative homeostasis and mitochondrial stability
by the redox reactive thalidomide 2-(2,4-difluoro-phenyl)-4,5,6,7-tetrafluoro-1H-isoindole-1,3(2H)-dione
(CPS49) and flavopiridol”. Mol Pharmacol. (2008) 74:872-83. Epub 2008 Jun 12.
2) De Siervi A, Idelman G, Tongbai R, De Luca P, Gueron G, Chandramouli1 GVR, Rustici G, Haggerty C,
Dzekunova I, Petersen D, Kawasaki E, Kil WK, Camphausen K, Longo D, Gardner K. “Identification of new
Rel/NF-kappaB regulatory networks by focused genome location analysis”. Cell Cycle (2009) Volume 8,
Issue 13, July 1.
3) Gueron G, De Siervi A, Ferrando M, Salierno M, De Luca P, Elguero B, Meiss R, Navone N, Vazquez, E.
“Critical role of endogenous heme oxygenase 1 (HO-1) as a tuner of the invasive potential of prostate
cancer cells”. Mol. Cancer Res. 7 (2009) 1745-55.
4) Gueron G; A. De Siervi; E.Vazquez. “Key questions in metastasis: new insights in molecular pathways and
therapeutic implications”. Current Pharmaceutical Biotechnology Apr 6. (2011) [Epub ahead of print]
5) De Luca P, Vazquez E, Moiola C, Zalazar F, Cotignola F, Gueron G, Gardner K, De Siervi A. “BRCA1 loss
induces GADD153-mediated doxorubicin resistance in prostate cancer." Mol Cancer Res (2011) Jun 23.
[Epub ahead of print]
6) Ferrando M*, Gueron G*, F, Elguero B, Giudice, J.; Salles, A.; Coluccio Leskow, F.; Jares-Erijman, E.A.;
Colombo, L.; Meiss, R.; Navone, N.; De Siervi, A.; Vazquez, E. “Heme oxygenase 1 (HO-1) challenges the
angiogenic switch in prostate cancer” Angiogenesis (2011). Dec;14(4):467-79.
7) Gueron G, De Siervi, A.; Vazquez, E. “Advanced prostate cancer: reinforcing the strings between
inflammation and the metastatic behavior”. Prostate Cancer and Prostatic Diseases (2011) Sep;15(3):21321.
8) Elguero, B.; Gueron, G.; Giudice, J, Toscani, A.M.; De Luca, P. ; Zalazar, F. ; Coluccio Leskow, F.; Meiss,
R.; Navone, N.; De Siervi, A.; Vazquez, E.”UNVEILING THE ASSOCIATION OF STAT3 AND HO-1 IN
PROSTATE CANCER: ROLE BEYOND HEME DEGRADATION” Neoplasia (2012) November 2012; Vol.
14, No. 11
9) Gueron G, Cotignola J, Vazquez E. INFLAMMATORY MICROENVIRONMENT IN PROSTATE
CARCINOGENESIS. Book chapter of “BOOK TITLE: Advances in Prostate Cancer. (INTECH open access
publisher, (2012)) ISBN 980-953-307-719-7.
D. Research Support.
Completed
PICT-RAICES (2006-00367)
Role of HO1 and VEGF in prostate cancer bone metastasis.
National Agency for the Scientific and Technological Promotion (co-Investigator).
10/25/2008-10/25/2010 Amount (U$S 67,900.00)
Role: co-investigator
The goal of this Project is to investigate the role of the regulatory loop between HO-1 and VEGF in the
interaction between bone and prostate cancer cells.
UBACYT (X230)
HO-1 and VEGF in prostate cancer bone metastasis.
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Principal Investigator/Program Director (Last, First, Middle):
Gueron, Geraldine
University of Buenos Aires (PI)
2008-2010 Amount (U$S 16,000.00)
The goal of this project is to understand the role of VEGF and HO1 in prostate cancer progression.
Role: co-investigator
ORT (2012)
Proteomic Analysis of HO-1 in Prostate Cancer
Amount (U$S 2000)
Role: Principal investigator
Ongoing
PICT-RAICES (2010-0431)
Role of nuclear localization of HO-1 in prostate cancer progression
National Agency for the Scientific and Technological Promotion
04/25/2011-10/25/2013 Amount (U$S 67,900.00)
The goal of this Project is to investigate the role of the nuclear localization of HO-1 1 in prostate cancer.
Role: co-investigator
UBACYT (20020100100179)
Nuclear role of HO-1 in prostate cancer progression.
University of Buenos Aires
2011-2014 Amount (U$S 16,000.00)
The goal of this Project is to investigate the role of the nuclear localization of HO-1 in prostate cancer.
Role: co-investigator
PICT-RAICES (2010-0431)
Role of nuclear localization of HO-1 in prostate cancer progression
National Agency for the Scientific and Technological Promotion
04/25/2011-10/25/2013 Amount (U$S 67,900.00)
The goal of this Project is to investigate the role of the nuclear localization of HO-1 1 in prostate cancer.
Role: co-investigator
PCF award (2013-1015)
Role of nuclear localization of HO-1 in prostate cancer progression
Prostate Cancer Foundation
Amount (U$S 225.000)
The goal of this Project is to investigate the role of the nuclear localization of HO-1 1 in prostate cancer.
Role: Principal Investigator
PICT (2013-2014)
National Agency for the Scientific and Technological Promotion
04/25/2011-10/25/2013 Amount (U$S 10.000)
Role: Principal Investigator
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