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Course Basic and Translational Oncology 2015
February 2-6, 2015
Version 150128
The postgraduate school Molecular Medicine (MolMed) has been organizing the
Basic and Translational Oncology course for many years now – in cooperation with
the school Medical Genetic Center (MGC) and with contributions from many
moderators and speakers from the LUMC. The course provides a comprehensive
introduction to the field of translational cancer research.
The course is directed primarily at PhD students and postdocs in MolMed and MGC,
but others (e.g., students and technicians of LUMC and Erasmus MC) are welcome
too. The maximum number of participants is 40. The course fee is €750. However,
some participants are entitled to a discount; see below for all information.
The program is set up logically in 5 steps, one step a day:
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Pathology, diagnostics & pathways in cancer
Biology of the cancer cell: Genetics & Epigenetics
Genetic susceptibility, invasion & metastasis
Clinical practice: diagnostics & targeted therapies
Translational research, epidemiology of cancer, cancer data in research & endof-life interventions
We are proud to announce again some famous keynote speakers. We
especially welcome the Visiting Professor on behalf of the Daniel den
Hoed Foundation, prof.dr. Norman Maitland who will give a keynote
lecture and a master class, and prof.dr. Charles Swanton who will give a
keynote lecture. And again Douglas Easton, University of Cambridge,
Strange-ways Research Lab; and Piet Borst and Jos Jonkers (NCI). From
Erasmus MC, Ruud Delwel will give a keynote talk. All their lectures will
be announced more widely.
Like last year, the program is enriched with journal clubs (JC’s) and lab
sessions with course speakers. Publications to be discussed are
announced one month in advance to all participants. We expect you to
prepare these before the course starts. All participants are expected to
give a short presentation during one of the the JC’s. These will be
organised during the first 2 days of the course. We apologize for the
cancellation of the Journal Club by Prof. Swanton on Tuesday.
The amount of ECTS awarded for the entire course is 1.8.
At the start of the course, participants will receive a comprehensive reader
consisting of recent papers relevant to the lectures.
Please register via: www.molmed.nl. Give your preferred JC’s in the free
text field on the web form. We’ll send you the assignments & publications.
Later registrations will get their assignment as well, but have less choice.
Frank van Vliet will be pleased to answer organizational questions (010-704 3518
or 06-5474 6408; [email protected]).
Els Berns, Erasmus MC
Monique den Boer, Erasmus MC
Reno Debets, Erasmus MC
Peter Devilee, LUMC
Peter ten Dijke, LUMC
Frank van Vliet, MolMed/Erasmus MC
Ellen Zwarthoff, Erasmus MC
Monday February 2
Pathology, diagnostics & pathways in cancer
Moderator: Peter ten Dijke, LUMC. Room: Ae 4.06
Time
Speaker
Title
08.45-09.15
09.15-09.30
09.30-10.15
10.15-11.00
11.00-11.15
11.15-12.00
12.00-13.00
13.00-14.00
14.00-14.45
14.45-15.00
15.00-15.45
16.00-17.15
JC 1: Ae-3.27
JC 2: Be-2.36
JC 3: Ae-4.06
JC 4: Be-2.40
Registration & coffee
Peter ten Dijke, LUMC
Wolter Oosterhuis,
Erasmus MC
Winand Dinjens,
Erasmus MC
Coffee break
Pim French, Erasmus
MC
Lunch. Room: Ae 4.06
Key Note: Norman
Maitland, Visiting
professor on behalf
of the Daniel den
Hoed Foundation
Peter ten Dijke, LUMC
Introduction of the theme of the day
The pathology of cancer
(This lecture will be different from the one in the MolMed Course in
March)
Molecular Diagnostics in solid tumors
Omics as a diagnostic tool for brain tumors
1-Epigenetic control of cellular differentiation in
normal and malignant human prostate
2-Targeted therapies for the tumour inducing cells
in human prostate cancer
(combined with the JNI scientific lab meeting)
TGF β in cancer
Coffee break
Leendert Looijenga,
(Epi)Genetics in normal and malignant germ cell
Erasmus MC
development
Journal clubs & short presentations (4 groups)
Rooms for Journal Clubs: Ae-4.06, Be-2.36, Ae-3.14, Be-2.40
The journal clubs intend to evaluate what was learnt today: What scientific
questions are asked and what does science teach us? Some publications about the
topics covered today will be discussed. The practical session on an 18-header
microscope will teach you a lot about a pathologist’s view on many cancer
phenotypes.
Winand Dinjens,
Journal club on selected publications
Erasmus MC
Peter ten Dijke, LUMC
Journal club on selected publications
Norman Maitland,
Journal club on selected publications
Visiting professor
Wolter Oosterhuis,
Practical: cancer pathology (on 18-header microscope)
Erasmus MC
Tuesday February 3
Biology of the cancer cell: Genetics & Epigenetics
Moderator: Peter Devilee, LUMC (morning); Ronald Stam, Erasmus MC (afternoon).
Room: Ae 4.06
Time
Speaker
Title
09.15-09.30
09.30-10.15
10.15-11.00
11.00-11.15
11.15-12.00
12.00–13.00
13.00-13.45
13.00–13.45
13.45-14.30
14.30-14.45
14.45-15.30
15.30-16.15
16.1517.15
JC 2: Ae3.27
JC 3: Ae4.06
Peter Devilee, LUMC
Introduction of the theme of the day
Peter Devilee
Genetic susceptibility
Daniel Peeper, NCI,
Senescence in cancer
Amsterdam
Coffee break
Valery Lemmens, NCI
The quantitative burden of cancer
Keynote: Charles
Cancer Evolution: Causes and Consequences
Swanton, London
Research Institute
Lunch. Room: Ae 4.06
‘Meet the professor’ lunch with Charles Swanton
Ronald Stam, Erasmus
Epigenetic malignancies require epigenetic drugs
MC
Coffee break
Peter Verrijzer, Erasmus Chromatin remodelling and human cancer
MC
Reuven Agami, NCI
EnhancerRNAs in cancer
Journal clubs & short presentations (3 groups)
Rooms for Journal Clubs: Ae-406, Be-2.36, Be-3.36
The journal clubs today intend to discuss the scientific questions behind the
publications: what are the scientific questions, does the experimental design fit
with these questions, and are the conclusions scientifically proven and valid?
Publications about the topics covered today, will be discussed. The participants are
encouraged to give their own opinions about these questions. The publications will
be announced before the course starts, participants are advised to read them in
advance.
Reuven Agami, NCI
Journal club on selected publications
Ronald Stam, Erasmus
MC
Journal club on selected publications
Wednesday February 4
Genetic susceptibility, invasion & metastasis
Moderator: Monique den Boer, Erasmus MC. Room: Erasmus MC, Ae 4.06
Time
Speaker
Title
09.30-10.15
10.15-11.00
11.00-11.30
11.30-12.15
Today, all speakers will conclude their talks with some propositions. The
participants are encouraged to discuss these propositions with the speakers after
their talk or during the breaks.
Riccardo Fodde,
Stem cells in homeostasis and cancer: the good, the
Erasmus MC
bad and the ugly
Mihaela Crisan, Erasmus Stromal cells and hematopoiesis in normal organs and
MC
disease
Discussion with previous speakers; coffee break
Keynote speaker:
Genome-wide views of cancer susceptibility
Douglas Easton,
University of
Cambridge, Strangeways Research Lab
12.15-13.15
12.15–13.15
13.15-14.00
14.00-14.45
14.45-15.15
15.15-16.00
16.00-16.45
16.45-17.15
Lunch. Room: Ae 4.06
‘Meet the professor’ lunch with Douglas Easton, University of Cambridge
Guido Jenster, Erasmus
Exosomes and micro-vesicles
MC
Seth Coffelt, NCI,
The inflammatory tumor microenvironment, a critical
Amsterdam
regulator of invasion and metastasis
Discussion with previous speakers; coffee break
Rudi Hendriks, Erasmus
Targeting Bruton's tyrosine kinase in B cell malignancies
MC
Wietske van Weerden,
Mechanisms of castration-resistant prostate cancer:
Erasmus MC
targeted therapies and potential bypass mechanisms in
preclinical models
Discussion with previous speakers
Thursday February 5
Clinical practice: diagnostics & targeted therapies
Moderator: Reno Debets, Erasmus MC. Room: Ae 4.06
Time
Speaker
Title
09.15-10.00
Reno Debets, Erasmus
MC
10.00-10.45
Nelleke Gruis, LUMC
10.45-11.00
11.00-11.45
Coffee break
Gabri van der Pluijm,
LUMC
11.45-12.45
Keynote speaker: Piet
Borst, NKI
Lunch. Room: Ae 4.06
‘Meet the professor’ lunch with Piet Borst, NCI (2 sessions of ½ hr)
‘Meet the professor’ lunch with Ruud Delwel (2 sessions of ½ hr)
Key note lecture: Ruud Genetics and epigenetics in human acute myeloid
Delwel, Erasmus MC
leukemia
Dominic Robinson,
PDT in clinical practice
Erasmus MC
Coffee break
Monique den Boer,
Development of targeted therapies in genetic
Erasmus MC
subclasses of childhood leukaemia
Timo ten Hagen, Erasmus Drug Delivery in Cancer: How to Improve
MC
Lab visit to lab of Timo ten Hagen, Erasmus MC (max. 10 participants):
Intravital microscopy, Ee-1.75
12.45–13.45
12.45–13.45
12.45–13.45
13.45-14.30
14.30-15.15
15.15–15.30
15.30-16.15
16.15-17.00
17.00-…
Introduction of the theme of the day;
TCR gene therapy to treat melanoma: lessons from
clinical and preclinical studies
Recent breakthroughs in the understanding of
melanoma susceptibility
'Near-patient' prostate cancer models for the
assessment of disease progression, drug development
& therapy response
Drug resistance mechanisms in a mouse tumor
model resembling human breast cancer
Friday February 6
Translational research, epidemiology of cancer, cancer data in research & end-of-life
interventions
Moderator: Ellen Zwarthoff, Erasmus MC . Room: Ae 4.06
Time
Speaker
Title
09.15-10.00
10.00-10.45
10.45–11.00
11.00-11.45
11.45-12.30
12.30–13.30
12.30–13.30
13.30-14.15
14.15-15.00
15.00-15.15
15.15-16.00
16.00-16.15
16.15-….
Monique Roobol, Erasmus Are we ready for population based screening for PC?
MC
Marjanka Schmidt/ Floor
Epidemiology of Breast cancer; genes, hormonal risk
van Leeuwen, NCI
factors and screening
Coffee break
Anieta Sieuwerts,
Liquid biopsies; circulating tumor cells and cell-free
Erasmus MC
DNA
Keynote speaker: Jos
Conditional mouse models of breast cancer
Jonkers, NCI
Lunch. Room: Ae 4.06
‘Meet the professor’ lunch: Jos Jonkers
Ellen Zwarthoff, Erasmus
Molecular diagnostics in bladder cancer
MC
Stefan Sleijfer, Erasmus
Treatment of patients with metastasised cancer
MC
Coffee break
Marijke Bontenbal,
Clinical practice: End-of-life decisions and end-of-life
Erasmus MC
interventions for terminal patients; discussion
Marijke Bontenbal &
Discussion on end-of-life interventions
participants
Final discussion, closure & drinks
Course fees
For non-commercial participants the course fee is € 750. Discounts:
 PhD students get a 50% discount and pay €375.
 Participants from the postgraduate school MolMed and one participant from
the group of a speaker get a 100% discount and pay €0.
 MGC members and master students, get a 50% discount and pay €375.
 Master students who have to pay the fee from their personal budget get a
75% discount and pay €187,50.
If these financial requirements should pose a problem, please contact Frank van Vliet, managing
director of the Erasmus Postgraduate School Mol Med, at: [email protected]
Invoice
Shortly after your registration you will receive and INVOICE per mail. Fees are
payable into bank account: 43.47.01.408/ Erasmus MC, (IBAN code bank:
NL86ANBA0434701408; SWIFT code bank: ABNANL2A); please state the number
on your INVOICE. Late participants can also pay in cash upon signing in.
Cancellations
The fees mentioned apply to the full five-day course. There is no discount when
attending only part of the course. Cancellation is possible up to one week
before the start of the course. Later cancellation will not be accepted, but you
are allowed to send a substitute.
Commercial participants & sponsors
Companies are invited to inquire about participation and sponsoring options.