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Ministero della Salute Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE CO‐2013‐ 02356242 PALMITOYLETHANOLAMIDE TO TARGET INFLAMMATION IN NEURODEGENERATIVE DISEASES: A STUDY FOCUSED ON PERIPHERAL IMMUNE CELLS SANTA LUCIA Bossù Paola Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT CO‐2013‐ 02356463 Genetic and functional predictors of response to biologic therapy in psoriasis. Lazio Costanzo Antonio Biomedica Immunology Hypersensitivity, Autoimmune, and Immune CO‐2013‐ 02357626 Development of selective inhibitors of crizotinib‐resistant Lombardia oncogenic ALK kinase Gambacorti‐ Passerini Carlo Biomedica Oncology 2 ‐ Translational Clinical Drug Discovery and Molecular Pharmacology ‐ DMP CO‐2013‐ 02357642 Identification of novel biomarkers of oocytes and embryos competence by molecular analysis of apoptosis in cumulus oophorus cells and of embryo secretome: prediction of Assisted Reproductive Technology (ART) outcome Colacurci Nicola Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Endocrinology, Metabolism, Nutrition and Reproductive Sciences (EMNR) Integrated Review Group Fellowship Panel ‐ F06 CO‐2013‐ 02358121 Development and optimization of a dedicated system for REGINA ELENA hyperthermia treatment of patients with superficial/semi‐ depth tumours Strigari Lidia Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Campania Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Radiation Therapeutics and Biology ‐ RTB Pagina 1 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE CO‐2013‐ 02358433 Development and validation of new assays for diagnosis and monitoring of infectious diseases using the DiaSorin Q‐LAMP Technology CO‐2013‐ 02358488 Tolerability and efficacy of Zinc therapy in Mild Cognitive Lazio Impairment for treatment and prevention of Alzheimer's disease: a prospective, randomized, double blind, parallel, placebo‐controlled Phase II clinical trial CO‐2013‐ 02358697 Extremely low frequency magnetic field (ELF‐MF) stimulation as a neuroprotective treatment in acute ischemic stroke. CO‐2013‐ 02359459 Copper‐64‐chloride as a novel diagnostic and therapeutic C.R.O. AVIANO (diapeutic) radiotracer in high grade ovarian cancer models CO‐2013‐ 02359461 Identification of predictive biomarkers in Multiple Sclerosis using a proteomic approach CO‐2013‐ 02359521 Novel adaptive electromechanical seating device, driven via multiple sensors, to improve the sitting posture of children with neurological diseases. CO‐2013‐ 02359690 GR‐2013‐ 02354797 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. BALDANTI FAUSTO Biomedica Rossini Paolo Maria Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Di Lazzaro Vincenzo Biomedica Emerging Technologies and Brain Disorders and Training in Neurosciences Related Neurosciences Fellowship ‐ F01 casagrande naike Biomedica Oncology 2 ‐ Translational Clinical Radiation Therapeutics and Biology ‐ RTB Istituto Superiore di Sanita' Margutti paola Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN OSPEDALE BAMBINO GESU' frascarelli flaminia Clinico‐ Emerging Technologies and Neurotechnology ‐ assistenzial Training in Neurosciences NT e Cardiac regeneration: Characterization, optimization and OSPEDALE BAMBINO GESU' evaluation of force developed by engineered tissue obtained from spontaneous or scaffold based 3D culture of paediatric human adipose tissue‐derived mesenchymal stem cells Amodeo Antonio Biomedica Cardiovascular and Respiratory Sciences Cardiovascular Sciences Small Business SECS Clinical significance, role and plasticity of neutrophils in cancer Jaillon Sebastien Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS SAN MATTEO Lazio HUMANITAS Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Infectious Diseases and Microbiology Small Business: Non‐ HIV Infectious Agent Detection/Diagnostic s, Food Safety, Sterilization/Disinfec tion and Bioremediation ‐ SBID Clinical Neuroscience and Neurodegeneration ‐ CNN Pagina 2 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02354809 Development of novel imaging biomarkers for early detection of inherited and acquired neuro‐retinal degenerations and monitoring of disease progression in patients at a cellular level based on high‐resolution adaptive optics retinal imaging BIETTI Lombardo Marco Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Medical Imaging ‐ MEDI GR‐2013‐ 02354812 AUTOLOGOUS OR UMBILICAL CORD DERIVED GROWTH FACTORS AS A NON‐PHARMACOLOGICAL AND MINI‐INVASIVE PREVENTIVE APPROACH TO ENHANCE BONE FRACTURE HEALING AND AVOID DELAYED UNIONS AND NONUNIONS THROUGH A RANDOMIZED CONTROLLED CLINICAL STUDY AND PRECLINICAL EVID RIZZOLI Stagni Cesare Biomedica Musculoskeletal, Oral and Skin Sciences Skeletal Biology Structure and Regeneration ‐ SBSR GR‐2013‐ 02354815 New isoDGR‐based therapeutics: toward the design of pure integrin antagonists. SAN RAFFAELE MILANO Ghitti Michela Biomedica Biological Chemistry and Macromolecular Biophysics Macromolecular Structure and Function B ‐ MSFB GR‐2013‐ 02354816 Chromogranin‐A and its derived peptides as predictive markers of complex ventricular arrhythmias in patients with dilated cardiomyopathy Calabria Angelone Tommaso Biomedica Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF GR‐2013‐ 02354818 Mast cells at the checkpoint decision between ISTITUTO TUMORI adenocarcinoma and neuroendocrine type prostate cancer MILANO Jachetti Elena Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME GR‐2013‐ 02354823 Dissecting the genetic control and associated transcriptional profile of common somatic mutations in lung adenocarcinoma Colombo Francesca Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD GR‐2013‐ 02354833 Integrated molecular analysis: identification of prognostic RIZZOLI biomarkers in metastatic Soft Tissue Sarcoma Conti Amalia Biomedica Oncology 1 ‐ Basic Translational Tumor Progression and Metastasis ‐ TPM2 GR‐2013‐ 02354843 Validation of tumor cell vulnerabilities identified by a siRNA‐based loss of function screening: a tool for the discovery of new potential therapeutic targets in thyroid carcinoma anania maria chiara Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB ISTITUTO TUMORI MILANO ISTITUTO TUMORI MILANO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 3 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02354848 CYTOKINE NETWORK UNDERLYING TH17 CELL‐ MEDIATED PATHOGENESIS IN MULTIPLE SCLEROSIS SANTA LUCIA VOLPE ELISABETTA Biomedica Immunology Cellular and Molecular Immunology A ‐ CMIA GR‐2013‐ 02354851 An innovative nanomotion detection tool to perform a rapid analysis of the response to drugs of poorly differentiated and anaplastic thyroid cancer REGINA ELENA Longo Giovanni Biomedica Oncology 2 ‐ Translational Clinical Developmental Therapeutics ‐ DT GR‐2013‐ 02354853 MITO‐AGE: LINKING THE MITOCHONDRIAL GENOME TO HEALTHY AND PATHOLOGICAL AGING Istituto Scienze Neurologiche Caporali Leonardo Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD GR‐2013‐ 02354862 TUMOR‐RESPONSIVE NANOCARRIERS BASED ON THE HUMAN FERRITIN FOR CANCER THERAPY REGINA ELENA Falvo Elisabetta Biomedica Bioengineering Sciences and Technologies Nanotechnology ‐ NANO GR‐2013‐ 02354867 Health‐related quality of life and psychosocial functioning in head and neck cancer patients treated with curative intent: A prospective study ISTITUTO TUMORI MILANO Monzani Dario Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD GR‐2013‐ 02354881 Role played by bats and other animals/parasites in the widespread of MERS‐CoV IZSME Amoroso Maria Grazia Biomedica Infectious Diseases and Microbiology Clinical Research and Field Studies of Infectious Diseases ‐ CRFS GR‐2013‐ 02354886 Adaptive prosthetic socket for transfemoral amputees DON GNOCCHI Monaco Vito Biomedica Emerging Technologies and Clinical Training in Neurosciences Neurophysiology, Devices, Auditory Devices and Neuroprosthesis Small Business ‐SBNE GR‐2013‐ 02354887 A Cell‐Based High‐Throughput Screening Assay for Transcriptional LARGE Up‐regulation in Dystroglycanopathies GASLINI Assereto Stefania Biomedica Musculoskeletal, Oral and Skin Sciences GR‐2013‐ 02354888 Cerebellar‐cortical circuits in Autism Spectrum Disorders: new perspectives for treatment implementation. SANTA LUCIA Clausi Silvia Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Skeletal Muscle Biology and Exercise Physiology ‐ SMEP Clinical Neuroscience and Neurodegeneration ‐ CNN Pagina 4 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02354893 The emerging role of endoplasmic reticulum morphology MEDEA in lipid metabolism: investigation of molecular pathwasy and novel targets for Hereditary Spastic Paraplegia Orso Genny Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND GR‐2013‐ 02354901 Autosomal Dominant and sporadic Frontotemporal Lobar Degeneration: from non‐coding RNAs to the identification of preclinical biomarkers and therapeutic targets Fenoglio Chiara Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02354902 Smart Adoptive T cell therapy for prostate tumors: I. O. V. Endowing T cells with tools to overcome PD‐1 checkpoint Sommaggio Roberta Biomedica Immunology Transplantation, Tolerance and Tumor Immunology ‐ TTT GR‐2013‐ 02354909 Early treated patients with phenylketonuria: Cognitive, SANTA LUCIA metabolic and neuroimaging correlates of dietary control in the first generation of treated patients to reach adulthood. Palermo Liana Clinico‐ Biobehavioral and assistenzial Behavioral Processes e Cognition, Language and Perception Fellowship ‐ F12A GR‐2013‐ 02354915 Understanding the death program induced by MIF inhibition in CD74‐positive cells ISTITUTO TUMORI MILANO Varinelli Luca Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP GR‐2013‐ 02354916 Neutrophil gelatinase‐associated lipocalin (NGAL) and matrix metalloproteinases (MMPs) as biomarkers of prostate cancer development and progression C.R.O. AVIANO Polesel Jerry Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02354935 Can biological agents withdrawn in psoriatic arthritis (PsA) patients after a stable remission of arthritis is achieved? A clinical, radiological and ultrasonographic study. SAN GALLICANO Graceffa Dario Clinico‐ Musculoskeletal, Oral and assistenzial Skin Sciences e Arthritis, Connective Tissue and Skin ‐ ACTS GR‐2013‐ 02354936 Structural and functional characterization of a novel isoform of vascular endothelial growth factor A (VEGFA) PASCALE COSTANTINI SUSAN Biomedica Biological Chemistry and Macromolecular Biophysics Macromolecular Structure and Function D ‐ MSFD GR‐2013‐ 02354942 Cancer chemoprevention and therapy by phytochemical compounds on breast cancer overexpressing D16HER2 splice variant in young and old ages I.N.R.C.A. Pierpaoli Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT MAGGIORE Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Elisa Classificazione 1 Liv. Classificazione 2° liv. Pagina 5 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02354943 Repetitive transcranial magnetic stimulation with H‐coil to restore cortical inhibitory motor control in focal hand dystonia. SAN RAFFAELE MILANO Houdayer Elise Paule Patricia Biomedica GR‐2013‐ 02354944 Effects of heart rate reduction by ivabradine, an If current SAN RAFFAELE MILANO inhibitor, versus beta‐adrenergic blockade by carvedilol, on left ventricular function and myocardial energetics, in patients with systolic heart failure. Spoladore Roberto Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF GR‐2013‐ 02354945 Signaling effectors of the Trop‐2 pro‐metastatic network: Abruzzo novel targets for diagnosis and therapy Trerotola Marco Biomedica Oncology 1 ‐ Basic Translational Tumor Progression and Metastasis ‐ TPM2 GR‐2013‐ 02354951 Purification and quantification of cancer microRNA biomarkers using a Lab‐On‐a‐Chip microdevice and the droplet digital PCR technology Ferracin Manuela Biomedica Interdisciplinary Molecular Sciences and Training Small Business: Devices and Detection Systems ‐ SBDS GR‐2013‐ 02354960 Novel Biomarkers for Improved Characterization, Disease Associazione Oasi Maria SS Mondello Tracking and Outcome Prediction in Traumatic Brain Injury Stefania Biomedica Brain Disorders and Clinical Neuroscience Acute Neural Injury and Epilepsy ‐ ANIE GR‐2013‐ 02354962 Innovative biomaterials to promote peripheral nerve regeneration Cerri Federica Biomedica Emerging Technologies and Neurotechnology ‐ Training in Neurosciences NT GR‐2013‐ 02354968 New microRNAs involvement in the development of drug PASCALE resistance to targeted terapies in mestastatic melanoma Capone Mariaelena Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT GR‐2013‐ 02354969 Characterization of undiagnosed cerebellar ataxias. barca emanuele Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN Notartomaso Serena Biomedica Biology of Development and Aging Development‐1 ‐ DEV1 Emilia‐Romagna SAN RAFFAELE MILANO NEUROLESI AREA P.I. Classificazione 1 Liv. Brain Disorders and Clinical Neuroscience From biochemical biomarkers to novel therapeutic approaches GR‐2013‐ 02354971 NEUROMED Epigenetic down‐regulation of mGlu5 metabotropic glutamate receptors in Purkinje cells: a novel mechanism of synapse elimination in the developing cerebellum? Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Classificazione 2° liv. Clinical Neuroplasticity and Neurotransmitters ‐ CNNT Pagina 6 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02354972 Short‐term effects of the implementation of the NIDCAP model for very low birth weight babies Emilia‐Romagna LUGLI LICIA Clinico‐ Healthcare Delivery and assistenzial Methodologies e Nursing Science: Children and Families ‐ NSCF GR‐2013‐ 02354981 Implementation of first‐line chemotherapy of lung and pleural cancers by type I IFN: effects on chemoresistance and tumor immunogenicity Istituto Superiore di Sanita' Bracci Laura Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII GR‐2013‐ 02354986 Antigen‐loaded solid lipid nanoparticles for immunotherapy in glioblastoma Lombardia Panciani Pier Paolo Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII GR‐2013‐ 02354992 Uunraveling genetic diversity of nosocomial Candida NEUROLESI parapsilosis isolates using the restriction site associated DNA sequencing (RAD‐seq) technique as a novel tool for high‐resolution epidemiology Scordino Fabio Biomedica Infectious Diseases and Microbiology Pathogenic Eukaryotes ‐ PTHE GR‐2013‐ 02354995 Identification, clinical impact, and characterization of new genetic determinants of nonalcoholic fatty liver disease MAGGIORE Valenti Luca Vittorio Carlo Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD GR‐2013‐ 02355000 Study on the role of mechanical load‐mediated effects in the pathogenesis of osteosarcoma. OSPEDALE BAMBINO GESU' Peruzzi Barbara Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC GR‐2013‐ 02355010 Cystic Echinococcosis biomarker identification for diagnosis, cyst‐viability definition and therapy outcome prediction Istituto Superiore di Sanita' fratini federica Biomedica Infectious Diseases and Microbiology Pathogenic Eukaryotes ‐ PTHE GR‐2013‐ 02355011 Engineered regulatory T cell Adoptive Cell Therapy as a novel tool for the treatment of Cardiovascular diseases HUMANITAS KALLIKOURDI MARINOS S Biomedica Cardiovascular and Respiratory Sciences Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR GR‐2013‐ 02355015 Temozolomide‐based therapy in Ewing sarcoma patients: RIZZOLI prognostic and predictive role of MGMT promoter methylation Palmerini Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Emanuela Classificazione 1 Liv. Classificazione 2° liv. Clinical Oncology ‐ CONC Pagina 7 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02355018 New molecular mechanisms and biomarkers associated with anthracyclins and trastuzumab induced cardiotoxitity: role of the nucleolar protein Nucleophosmin and its associated miRNAs ISTITUTO DERMOPATICO DELL'IMMACOLATA Avitabile Daniele Biomedica Cardiovascular and Respiratory Sciences Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR GR‐2013‐ 02355027 Inhibition of miR‐125b in the SOD1‐G93A mouse as innovative approach to restrain Amyotrophic Lateral Sclerosis SANTA LUCIA Parisi Chiara Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02355028 New mTOR inhibitors development and study of their effects on the central nervous system(mTORNEU) Calabria Russo Emilio Biomedica Brain Disorders and Clinical Neuroscience Acute Neural Injury and Epilepsy ‐ ANIE GR‐2013‐ 02355029 Role of z‐Crystallin in acidic tumor microenvironment: molecular mechanisms and therapeutics implications Toscana Lulli Matteo Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP GR‐2013‐ 02355033 p53 control of the autophagic process in a model of Alzheimer's Disease SANTA LUCIA Merlo Paola Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN GR‐2013‐ 02355035 "Antivir‐aging": exploiting plasmacytoid Dendritic Cell response as a bridge between innate and adaptive immunity to improve influenza vaccine efficacy in the elderly Istituto Superiore di Sanita' Severa Martina Biomedica Immunology Innate Immunity And Inflammation ‐ III GR‐2013‐ 02355036 ROLE OF THE DIET IN THE MAINTENANCE OF REMISSION IN PEDIATRIC INFLAMMATORY BOWEL DISEASE: A PROSPECTIVE, RANDOMIZED, CONTROLLED, PARALLEL‐GROUP STUDY. Lazio Aloi Marina Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Clinical, Integrative and Molecular Gastroenterology ‐ CIMG GR‐2013‐ 02355038 NK cells for the Prevention of HCV recurrence in liver transplantation Sicilia Badami Ester Biomedica Innate Immunity And Inflammation ‐ III Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Immunology Classificazione 2° liv. Pagina 8 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02355039 Engineered bio‐organ for beta cell replacement in type 1 diabetes SAN RAFFAELE MILANO Valeria Daniela Sordi Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Diabetes, Metabolism, Nutrition and Obesity Small Business SEP (EMNR E10 B) GR‐2013‐ 02355042 Design of novel polyether ether ketone (PEEK) implants coated with nanostructured biomimetic apatite for osteoporotic patients RIZZOLI Bianchi Michele Biomedica Bioengineering Sciences and Technologies Biomaterials and Biointerfaces ‐ BMBI GR‐2013‐ 02355044 Non‐classical MHC‐I human leukocyte antigen G (HLA‐ G) in hepatocellular carcinoma BURLO GAROFALO Segat Ludovica Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e GR‐2013‐ 02355054 Study on the role of gonadal hormones on ACTH‐ secreting pituitary adenomas AUXOLOGICO Cassarino Maria Francesca Biomedica GR‐2013‐ 02355055 Proof‐of‐Concept prospective randomized controlled trial GASLINI on early treatment with either high‐ or standard‐dose caffeine in very preterm infants to evaluate the effects on brain development and respiratory morbidity. Bruschettini Matteo Biomedica GR‐2013‐ 02355056 ACTonFood. Feasibility, Effectiveness and Cost‐ effectiveness of a stepped‐care, web‐based Acceptance and Commitment therapy for food addiction in obese patients with pre‐diabetes or Type‐II diabetes seeking treatment for weight‐loss and related co‐morbidi AUXOLOGICO Manzoni Gian Mauro Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO GR‐2013‐ 02355063 Establishment of a new preclinical model of late stage, prostatectomized prostate cancer. Assessing the impact of prostate ablation on the spread of nodal and extra‐ nodal prostate cancer metastases. SAN RAFFAELE MILANO Buono Roberta Biomedica Tumor Progression and Metastasis ‐ TPM2 GR‐2013‐ 02355073 Study of the kynurenine pathway in schizophrenia: searching for novel peripheral biomarkers and therapeutic strategies. NEUROMED Fazio Francesco Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Cancer Immunopathology and Immunotherapy ‐ CII Endocrinology, Metabolism, Nutrition and Reproductive Sciences Molecular and Cellular Endocrinology ‐ MCE Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD Oncology 1 ‐ Basic Translational Clinical Neuroscience and Neurodegeneration ‐ CNN Pagina 9 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02355082 Rescue strategies of dopamine signalling dysfunction in inherited dystonias. GR‐2013‐ 02355084 MONZINO Alterations of Antioxidant Systems and Nitric Oxide Biosynthetic Pathway in the Progression of Calcific Aortic Valve Disease GR‐2013‐ 02355087 At the cross‐road between mucosal inflammation and carcinogenesis: new therapeutic approaches to modulate inflammasome‐dependent lung cancer progression. GR‐2013‐ 02355091 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Tassone Annalisa Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN Poggio Paolo Biomedica Cardiovascular and Respiratory Sciences Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR DE BELLIS Sorrentino Rosalinda Biomedica Immunology Innate Immunity And Inflammation ‐ III Gene therapy approaches to correct corneal disorders in EEC syndrome caused by mutations in p63 gene. Veneto Barbaro Vanessa Biomedica Genes, Genomes and Genetics Therapeutic Approaches to Genetic Diseases ‐ TAG GR‐2013‐ 02355093 Novel Immunotherapeutic strategy combining Unconventional T cells with Dendritic Cell‐based vaccination in Renal Cell Carcinoma. Puglia Gigante Margherita Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII GR‐2013‐ 02355095 Molecular characterization of tumor‐associated macrophages in human colorectal cancer. I.E.O. Ghisletti Serena Maria Luisa Biomedica Genes, Genomes and Genetics Molecular Genetics ‐ MGA GR‐2013‐ 02355106 Prospective evaluation of prevalence and risk factros of de novo metabolic syndrome after liver transplantation Veneto Germani Giacomo Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Clinical, Integrative and Molecular Gastroenterology ‐ CIMG GR‐2013‐ 02355107 Evaluation of the secondary epileptogenesis hypothesis and definition of possible biomarkers CARLO BESTA Noè Francesco Biomedica Brain Disorders and Clinical Neuroscience Acute Neural Injury and Epilepsy ‐ ANIE GR‐2013‐ 02355108 UNRAVELLING THE CAUSE‐EFFECT RELATIONSHIP BETWEEN PERFORMANCE‐ENHANCING DRUG ABUSE AND CARDIOVASCULAR IMPAIRMENT SDN Imperlini Esther Biomedica Risk, Prevention and Health Behavior Risk, Prevention and Intervention for Addictions ‐ RPIA SANTA LUCIA Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 10 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02355110 SPALLANZANI Impact of anti‐HCV prophylaxis with new direct active antivirals to prevent recurrence of infection in candidates to liver transplant. GR‐2013‐ 02355112 A NEW CHEMICAL BIOLOGY APPROACH FOR PRION DISEASES GR‐2013‐ 02355130 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Simone Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS Istituto Superiore di Sanita' Massignan Tania Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN Research on molecular pathways of renal damage and their modulation in experimental and clinical models of congenital uropathyby using nanocarriers Puglia Pastore Valentina Biomedica Bioengineering Sciences and Technologies Nanotechnology ‐ NANO GR‐2013‐ 02355131 MiR‐34a: novel player and potential therapeutic target in vascular calcification MONZINO Badi Ileana Biomedica Vascular and Hematology Vascular Cell and Molecular Biology ‐ VCMB GR‐2013‐ 02355135 Unravelling the role of the serine‐threonine kinase Ulk1 in axon growth and regeneration SANTA LUCIA Nazio Francesca Biomedica Molecular, Cellular, and Developmental Neuroscience Neurodifferentiation, Plasticity, and Regeneration ‐ NDPR GR‐2013‐ 02355136 Human urinary proteome in normality and in diseases: new technology approaches and strategies GASLINI Santucci Laura Biomedica Digestive, Kidney and Urological Systems Pathobiology of Kidney Disease ‐ PBKD GR‐2013‐ 02355137 Dissecting and targeting HS1 mediated cytoskeletal activity in Chronic Lymphocytic Leukemia cells and co‐ evolving microenviroment SAN RAFFAELE MILANO Scielzo Cristina Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB GR‐2013‐ 02355140 Role of ghrelin gene‐derived peptides and Exendin‐4 on Piemonte immune response and inflammation in lymphocytes from type 1 diabetic patients Trovato Letizia Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular Aspects of Diabetes and Obesity ‐ CADO GR‐2013‐ 02355143 Long non coding RNA as serum marker to predict response to sorafenib in Hepatocellular carcinoma Emilia‐Romagna Baglioni Michele Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02355145 Pharmacological bolstering of lipid rafts catalytic function in targeting lymphoma Istituto Superiore di Sanita' ciarlo laura Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT Lanini Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 11 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02355151 Patients' induced pluripotent stem cells for therapy personalization: the paradigm of thiopurine induced pancreatitis in Crohn's disease BURLO GAROFALO GR‐2013‐ 02355159 Cost and effectiveness evaluations of actions that can be included in the National Radon Action Plan and production of other relevant data useful for its development. Istituto Superiore di Sanita' Antignani GR‐2013‐ 02355162 Lombardia Quantification and comparison of endoscopic and microscopic approaches to the skull base: application of a novel, neuronavigation‐based, research method for the development of evidence‐based, preclinical studies in skull base surgery GR‐2013‐ 02355168 The RNA binding protein FMRP and hnRNP C: new target for regulating amyloid precursor protein levels in alzheimer disease GR‐2013‐ 02355178 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Gabriele Biomedica Sara Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD Doglietto Francesco Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma ‐ SAT SANTA LUCIA borreca antonella Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND Traumatic stress, microRNAs and synaptic plasticity: implications for post‐traumatic stress disorder SANTA LUCIA Rinaldi Arianna Biomedica Brain Disorders and Clinical Neuroscience Pathophysiological Basis of Mental Disorders and Addictions ‐ PMDA GR‐2013‐ 02355179 INVESTIGATION OF MOLECULAR BASIS OF AGGRESSIVENESS IN SYSTEMIC MASTOCYTOSIS Toscana Pieri Lisa Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02355188 Prenatal exposure to polybrominated diphenyl ethers: molecular mechanisms of developmental neurotoxicity and neurofunctional implications in a mouse model MARIO NEGRI De Paola Massimiliano Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND GR‐2013‐ 02355191 Oxidative stress and amyotrophic lateral sclerosis (ALS): the role of MDM4 SANTA LUCIA Mancini Francesca Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN Stocco Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Digestive, Kidney and Urological Systems Xenobiotic and Nutrient Disposition and Action ‐ XNDA Pagina 12 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02355192 MCL‐1 as progonostic/theranostic marker in paediatric patients affected by Acute Lymphoblastic Leukaemia (ALL) BURLO GAROFALO Franca Raffaella Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS GR‐2013‐ 02355193 An integrated molecular and functional approach to understand the phenotypic variability in ciliopathies CASA SOLLIEVO SOFFERENZA Romani Marta Biomedica Molecular, Cellular, and Developmental Neuroscience Neurogenesis and Cell Fate ‐ NCF GR‐2013‐ 02355205 BIOMARKER‐DRIVEN RATIONAL COMBINATION THERAPIES TO IMPROVE RESPONSE TO ANTI‐EGFR TREATMENT IN COLORECTAL CANCER: A PRECLINICAL STUDY, TAILORED AROUND HYPOTHESIS‐GENERATING PREDICTORS, IN PATIENT‐DERIVED XENOGRAFTS Istituto Oncologico Candiolo BERTOTTI Andrea Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT GR‐2013‐ 02355210 Extra‐corporeal membrane oxygenation vs. conventional CardioPulmonary Resuscitation for refractory out of hospital cardiac arrest: a randomized controlled trial ‐ E‐ CPR study Lombardia Mauri Tommaso Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS GR‐2013‐ 02355213 Phase II Trial of Temozolomide in Patients affected by Relapsed Sensitive or Refractory Small Cell Lung Cancer with MGMT methylation Emilia‐Romagna Casanova Claudia Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC GR‐2013‐ 02355217 mTOR inhibition‐mediated neuroprotection in mitochondrial disorders: molecular mechanisms and therapeutic effects. Toscana Felici Roberta Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN GR‐2013‐ 02355221 An innovative machine perfusion (Bologna Perfusion Machine) for abdominal organ preservation before transplantation. Optimization of perfusion, temperature and oxygenation related variables Emilia‐Romagna Ravaioli Matteo Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences ‐ BTSS GR‐2013‐ 02355222 Detection of gene polymorphisms associated to cardiovascular risk in saliva of Periodontitis patients: biochip design for Routine Diagnostic Testing Sicilia Isola Gaetano Clinico‐ Risk, Prevention and assistenzial Health Behavior e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Risk, Prevention and Intervention for Addictions ‐ RPIA Pagina 13 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02355233 HIV‐1 Tat interaction with host microRNA regulatory network: implications for immune and neuronal dysfunction GR‐2013‐ 02355244 Exploring the genetic landscape of Chronic Lymphocytic SAN RAFFAELE MILANO Leukemia by focusing on stereotyped subsets to decrease the heterogeneity of the disease: a novel approach to unveil potential markers of prognosis and targets for therapy. GR‐2013‐ 02355246 PD‐L1+ hematopoietic stem cells: a novel stem cell‐based SAN RAFFAELE MILANO approach for type 1 diabetes GR‐2013‐ 02355252 Identify the epigenetic alterations underlying monocyte dysregulation in Systemic Sclerosis: the path toward novel therapeutic opportunities GR‐2013‐ 02355253 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Biomedica AIDS and Related Research AIDS Immunology and Pathogenesis ‐ AIP Agathangelidis Andreas Biomedica Oncology 1 ‐ Basic Translational Cancer Genetics ‐ CG D'addio Francesca Biomedica Immunology Transplantation, Tolerance and Tumor Immunology ‐ TTT Veneto Rossato Marzia Biomedica Immunology Hypersensitivity, Autoimmune, and Immune Population‐based patient registry of chronic cholestatic, autoimmune liver disease in Lombardia and Denmark and development of a risk‐stratified healthcare pathway for the disease HUMANITAS Carbone Marco Clinico‐ Population Sciences and assistenzial Epidemiology e Social Sciences and Population Studies ‐ SSPS GR‐2013‐ 02355258 CDKL5‐associated disorders and brain Rho GTPases: in search of innovative therapeutic targets Istituto Superiore di Sanita' De Filippis Bianca Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD GR‐2013‐ 02355269 Dissecting melanoma heterogeneity by integrative genomic analysis for tailored anti‐cancer therapy ISTITUTO TUMORI MILANO Dugo Matteo Biomedica Genes, Genomes and Genetics Genomics, Computational Biology and Technology ‐ GCAT GR‐2013‐ 02355270 Advanced structural and functional Magnetic Resonance at 1,5T, 3T and UHF (7T) in distal Neuromuscular Disorders STELLA MARIS Astrea Guja Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Calabria Fiume Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Giuseppe Medical Imaging ‐ MEDI Pagina 14 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02355276 tDCS over the left frontal area speeds‐up speech recovery SANTA LUCIA in severe post‐stroke aphasia FIORI VALENTINA Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02355278 Quantification of cerebral oxygen metabolism for neurological diseases using MRI. SANTA LUCIA Gili Tommaso Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02355279 The role of the protein tyrosine phosphatase PTPN22 in the pathogenesis of autoimmunity in common variable immunodeficiency SAN MATTEO BORGHESI ALESSANDRO Biomedica Immunology Hypersensitivity, Autoimmune, and Immune GR‐2013‐ 02355285 IRCCS AOU San Martino‐ Modulation of endogenous circulating endothelial progenitor cells protects from subarachnoid haemorrhage IST (Genova) induced vasospasm and delayed ischemic injury Bacigaluppi Susanna Biomedica Brain Disorders and Clinical Neuroscience Brain Injury and Neurovascular Pathologies ‐ BINP GR‐2013‐ 02355288 Analysis of biomolecular profile in human meningiomas. Identification of potential targets for novel therapeutic strategies in recurring or not resectable tumours. Sicilia Barresi Valeria Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC GR‐2013‐ 02355292 Skin tumor models to study mechanisms of cancer regression Sicilia Zito Giovanni Biomedica Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ‐ ACTS GR‐2013‐ 02355295 Contributing role of viral infection in idiopathic pulmonary fibrosis (IPF) in comparison to non‐IPF interstitial lung diseases: clinical and experimental study of the principal pathogenetic pathways involved in fibrogenesis. Veneto LUNARDI FRANCESCA Biomedica Cardiovascular and Respiratory Sciences Lung Injury, Repair, and Remodeling ‐ LIRR GR‐2013‐ 02355296 Risk Of Hemorrhage in Cardioembolic Stroke Study (ROHCSS). A prospective study on neuroradiological and laboratoristic predictors of anticoagulant‐associated cerebral hemorrhage in cardioembolic ischemic stroke and transient ischemic attack. MAGGIORE Lanfranconi Silvia Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Acute Neural Injury and Epilepsy ‐ ANIE Pagina 15 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02355306 Molecular profile of exceptional responder patients with advanced non‐small cell lung cancer (NSCLC) or malignant pleural mesothelioma (MPM) GR‐2013‐ 02355311 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Tiseo Marcello Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS Quantitative lung ultrasonography to assess extravascular Liguria lung water and structural lung parenchymal derangements in acute respiratory failure. Brusasco Claudia Biomedica Cardiovascular and Respiratory Sciences Lung Injury, Repair, and Remodeling ‐ LIRR GR‐2013‐ 02355322 Longitudinal multi‐parametric clinical, CSF and MRI study aimed at predicting disability progression in Multiple Sclerosis Veneto Calabrese Massimiliano Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT GR‐2013‐ 02355325 Clinical value of percutaneous abdominal biopsy under PET‐CT/ultrasound fusion imaging guidance Liguria Paparo Francesco Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Medical Imaging ‐ MEDI GR‐2013‐ 02355344 Computerized measurement of Sarcopenia in patients with cirrhosis and hepatocellular carcinoma and application of a customized multidisciplinary protocol of nutritional support and motor rehabilitation in order to improve their outcome. Lazio BEGINI PAOLA Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC GR‐2013‐ 02355347 Immune profiling at tumor site to predict responsiveness ISTITUTO TUMORI to immunotherapy in non‐small cell lung cancer patients. MILANO Tassi Elena Biomedica Immunology Transplantation, Tolerance and Tumor Immunology ‐ TTT GR‐2013‐ 02355348 Proteins forming corona and interaction with hybrid nanoparticles: potential innovative strategy providing a new therapeutic approach for nanomedicine. SDN Celia Christian Biomedica Bioengineering Sciences and Technologies Gene and Drug Delivery Systems ‐ GDD GR‐2013‐ 02355349 The role of visuospatial abilities in the early differentiation between Dementia with Lewy Bodies and Alzheimer's disease: neuropsychological and neuroimaging evidence S.CAMILLO Mitolo Micaela Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02355350 Proteomics in thyroid pathology: MALDI‐ imaging as a new diagnostic tool Lombardia pagni fabio Biomedica Tumor Cell Biology ‐ TCB Emilia‐Romagna Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Oncology 1 ‐ Basic Translational Pagina 16 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02355358 Circulating molecular markers for personalized therapy in gliomas GR‐2013‐ 02355363 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Di Stefano Anna Luisa Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT MAGGIORE Identification of novel therapeutics for Spinal Muscular Atrophy with Respiratory Distress type 1 (SMARD1) using an iPSCmodel of the disease Simone Chiara Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02355376 Dementia vs cognitive preservation: differences and similarities in the genetic background I.N.R.C.A. Dato Serena Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND GR‐2013‐ 02355379 Promoting cerebral plasticity for the walking recovery in stroke by transcranial cerebellar direct current stimulation SANTA LUCIA Fusco Augusto Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Brain Injury and Neurovascular Pathologies ‐ BINP GR‐2013‐ 02355380 Role of microRNAs and bone morphogenetic proteins in calcific aortic valve disease Puglia Galeone Antonella Biomedica Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF GR‐2013‐ 02355381 Patient‐Specific Biomechanical Modeling for Customizing RIZZOLI the Surgery and Protecting the Cartilage of Patello‐ Femoral Joint Marcheggiani Giulio Maria Muccioli Clinico‐ Musculoskeletal, Oral and assistenzial Skin Sciences e Musculoskeletal, Oral and Skin Sciences Small Business ‐ SEMO GR‐2013‐ 02355382 SDN IMPACT OF CONTRACTILE RESERVE AND CORONARY FLOW RESERVE ON EXERCISE CAPACITY AND PROGNOSIS IN PATIENTS WITH NON‐ISCHEMIC DILATED CARDIOMYOPATHY. MECHANISTIC INSIGHTS FROM CARDIAC ADRENERGIC IMAGING. Gargiulo Paola Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS GR‐2013‐ 02355390 Cerebellum optimizes control of sensory‐motor coupling in fixational saccades Federighi Pamela Biomedica Cognitive Neuroscience ‐ COG MONDINO Toscana Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Cardiovascular and Respiratory Sciences Integrative, Functional, and Cognitive Neuroscience Pagina 17 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE Classificazione 1 Liv. Classificazione 2° liv. GR‐2013‐ 02355391 Diaphragmatic dysfunction in critically patients undergoing mechanical ventilation. Emilia‐Romagna Spadaro Savino Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Respiratory Integrative Biology and Translational Research ‐ RIBT GR‐2013‐ 02355393 Intercellular propagation of polyQ‐expanded proteins in Huntington disease:structural determinants, cellular mechanisms, and role in disease progression MARIO NEGRI Fioriti Luana Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02355395 Abruzzo Childhood obesity, Insulin Resistance (IR) and endothelial dysfunction: potential role of plasma miRNAs and endothelial Endoplasmic Reticulum (ER) stress. Marcovecchio Maria Loredana Biomedica Vascular and Hematology Vascular Cell and Molecular Biology ‐ VCMB GR‐2013‐ 02355396 Are alterations of plasma phospholipids predictive biomarkers for Alzheimer Disease? A metabolomics‐ based study of the effect of aging and neurodegeneration on metabolism. Leoni Valerio Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02355400 Cholinergic dysfunction as a common mechanism for IRCCS AOU San Martino‐ mild cognitive impairment (MCI) in cancer survivors and IST (Genova) patients with neurodegenerative diseases: multidisciplinary approach and interventional strategies. Morbelli Silvia Daniela Biomedica Integrative, Functional, and Cognitive Neuroscience Cognitive Neuroscience ‐ COG GR‐2013‐ 02355401 NEUROMED The role of authopagy as a protective mechanism in cardiovascular diseases: new insights into oxidative stress modulation and cardiovascular regeneration Sciarretta Sebastiano Biomedica Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF GR‐2013‐ 02355404 Personalized immunotherapeutic strategies for trastuzumab‐resistant HER2‐positive breast cancer Piemonte occhipinti sergio Biomedica Immunology Transplantation, Tolerance and Tumor Immunology ‐ TTT GR‐2013‐ 02355412 Functional inhibition of HSP105 as a new therapeutic strategy for human aggressive B‐cell non‐Hodgkin lymphomas ISTITUTO TUMORI MILANO Zappasodi Roberta Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB CARLO BESTA Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Pagina 18 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02355413 Role of Lamin A/C‐Polycomb crosstalk in Emery‐Dreifuss SANTA LUCIA Muscular Dystrophy (EDMD) Lanzuolo Chiara Biomedica Genes, Genomes and Genetics Molecular Genetics ‐ MGA GR‐2013‐ 02355416 Radiodynamic therapy and proton pump inhibitors for the treatment of pain in patients with bone metastases Avnet Sofia Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME GR‐2013‐ 02355417 Dissecting the epigenetic role of DNA repetitive elements MAGGIORE in muscle differentiation; implications for muscular dystrophy Bodega Beatrice Biomedica Genes, Genomes and Genetics Molecular Genetics ‐ MGA GR‐2013‐ 02355419 Identification and rescue of synaptic dysfunction in PINK1 autosomal recessive parkinsonism. SANTA LUCIA Madeo Graziella Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroplasticity and Neurotransmitters ‐ CNNT GR‐2013‐ 02355420 When my upper limb meets my lower pain: modulation of neuropathic pain after spinal cord injury through virtual embodiment and lower limbs control. SANTA LUCIA Tidoni Emmanuele Biomedica Brain Disorders and Clinical Neuroscience Brain Injury and Neurovascular Pathologies ‐ BINP GR‐2013‐ 02355424 Gender effects on cognitive rehabilitation in multiple sclerosis patients Sicilia Realmuto Sabrina Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02355427 Pharmacological strategies for infliximab response prediction and therapeutic monitoring in pediatric inflammatory bowel diseases BURLO GAROFALO Taddio Andrea Biomedica Digestive, Kidney and Urological Systems Clinical, Integrative and Molecular Gastroenterology ‐ CIMG GR‐2013‐ 02355431 RIZZOLI Dynamics of Lamin A interaction with multiprotein complexes in Emery‐Dreifuss Muscular Dystrophy (EDMD): identification of molecular and therapeutical targets for both diagnostic and novel therapies in nuclear lamina‐associated pathologies. Piazzi Manuela Biomedica Cell Biology Nuclear and Cytoplasmic Structure/Function and Dynamics ‐ NCSD GR‐2013‐ 02355434 Enhancers as new targets of intervention in glioblastoma relapse: from computational inference to functional validation Cristofanon Silvia Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB RIZZOLI I.E.O. Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 19 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02355440 Identification of molecular markers of consistency, potency and efficacy of IFN‐DC‐based drugs for lymphoma immunotherapy Istituto Superiore di Sanita' Castiello Luciano Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII GR‐2013‐ 02355441 Identification of the chromatin profile predicting the responsiveness of dystrophic patients to epigenetic therapy SANTA LUCIA Mozzetta Chiara Biomedica Musculoskeletal, Oral and Skin Sciences Skeletal Muscle Biology and Exercise Physiology ‐ SMEP GR‐2013‐ 02355445 Clinical and biological predictors of depression in chronic Veneto hepatitis C subjects treated with pegIFN‐alpha Tosato Sarah Biomedica Integrative, Functional, and Cognitive Neuroscience Neuroendocrinology, Neuroimmunology and Behavior ‐ NNB GR‐2013‐ 02355446 Identification of colorectal cancer (CRC)‐derived lipid antigens to enhance anti‐tumour iNKT cytotoxicity in antigen‐specific vaccination protocols I.E.O. Facciotti Federica Biomedica Immunology Transplantation, Tolerance and Tumor Immunology ‐ TTT GR‐2013‐ 02355449 Prevention of cancer therapy‐related heart failure through phosphoinositide 3‐kinase gamma inhibition Piemonte Morello Fulvio Biomedica Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF GR‐2013‐ 02355450 A new cellular model of Alzheimer's disease reproducing SAN MATTEO in vitro phatophysiological features of degenerating cells: a translational study to investigate the role of electromagnetic stimulation and circulating molecular biomarkers Venturini Letizia Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02355452 The role of urokinase (uPA) and its receptor (uPAR) in IBD pathogenesis: implication for novel therapeutic approaches. HUMANITAS Genua Marco Biomedica Immunology Innate Immunity And Inflammation ‐ III GR‐2013‐ 02355460 Unconventional role of the inhibitor of apoptosis (IAP) proteins in promoting metastatization ISTITUTO TUMORI MILANO Lecis Daniele Biomedica Oncology 1 ‐ Basic Translational Tumor Progression and Metastasis ‐ TPM2 GR‐2013‐ 02355467 Efficacy and safety of post‐operative double anti‐platelet therapy in patients revascularized with coronary artery bypass grafting Emilia‐Romagna Benassi Filippo Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Cardiovascular Sciences Small Business SECS Pagina 20 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02355474 Emilia‐Romagna INTERACTION BETWEEN MESENCHYMAL STEM CELL/STROMA AND HEMATOPOIETIC COMPARTMENT AFTER BONE MARROW TRANSPLANTATION: EFFECTS ON MAJOR OUTCOME OF TRANSPLANT. PREZIOSO LUCIA Biomedica GR‐2013‐ 02355479 Estimating the risk for cardiac toxicity in patients undergoing anticancer therapies: a new dynamic risk algorithm integrating levels of cardiovascular serum biomarkers. Liguria Puntoni Matteo Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC GR‐2013‐ 02355480 A novel use of CXCR4 inhibitors to prevent the dissemination of metastasis initiating cells induced by chemotherapy ISTITUTO TUMORI MILANO Bertolini Giulia Biomedica Oncology 1 ‐ Basic Translational Tumor Progression and Metastasis ‐ TPM2 GR‐2013‐ 02355483 Turning the blind brain to see. Restoration of visual functions in patients with cortical blindness using direct brain stimulation and biologically salient stimuli. MAUGERI Tamietto Marco Biomedica Integrative, Functional, and Cognitive Neuroscience Central Visual Processing ‐ CVP GR‐2013‐ 02355494 Targeting the oxytocinergic system in the treatment of psychiatric disorders programmed by early life stress NEUROLESI Marrocco Jordan Biomedica Integrative, Functional, and Cognitive Neuroscience Neuroendocrinology, Neuroimmunology and Behavior ‐ NNB GR‐2013‐ 02355501 Closed‐loop cerebro‐cerebellar connectivity: implications MONDINO for large‐scale network dysfunction in neurodegenerative diseases Palesi Fulvia Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Medical Imaging ‐ MEDI GR‐2013‐ 02355512 PHARMACOLOGICAL CHARACTERIZATION OF OXYTOCIN, DOPAMINE AND OPIOID RECEPTOR HETERODIMERS FOR THE DEVELOPMENT OF NEW THERAPEUTICAL MOLECULES FOR AUTISM AND SCHIZOPHRENIA HUMANITAS Busnelli Marta Biomedica Molecular, Cellular, and Developmental Neuroscience Molecular Neuropharmacology and Signaling ‐ MNPS GR‐2013‐ 02355513 Stepping toward the pathogenic role of Ambra1 complex in neuro‐muscular diseases: from animal models to therapeutic perspectives SANTA LUCIA Grumati Paolo Biomedica Biology of Development and Aging Cellular Mechanisms in Aging and Development ‐ CMAD Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Vascular and Hematology Hematopoiesis ‐ HP Pagina 21 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02355517 FATEBENEFRATELLI Trans‐generational transmission of vulnerability signatures for mental disorders: the role of early life stress and inflammation. Cattaneo Annamaria Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD GR‐2013‐ 02355521 Innovative technologies for minimal residual disease (MRD) in mature lymphoid tumors Piemonte Ferrero Simone Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02355523 Role of biological markers for cerebral bleeding risk stratification in patients with atrial fibrillation on oral anticoagulants for primary or secondary prevention of ischemic stroke Toscana Poggesi Anna Clinico‐ Biology of Development assistenzial and Aging e Aging Systems and Geriatrics ‐ ASG GR‐2013‐ 02355528 Iron depletion approach for the resolution of the HCV‐ induced steatohepatitis: development ofnew therapeutic strategy SPALLANZANI Mancone Carmine Biomedica Infectious Diseases and Microbiology Infectious Diseases and Microbiology Fellowship ‐ F13 GR‐2013‐ 02355536 Modulation of oxidative stress by superoxide dismutase 3 SDN (SOD3) in colorectal cancer (CRC) development and response to therapy castellone maria domenica Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC GR‐2013‐ 02355538 The microenvironment can influence the role of adipose stem cells in breast cancer recurrence. Sicilia di stefano anna barbara Biomedica Oncology 2 ‐ Translational Clinical Oncology 2 ‐ Translational Clinical Small Business [SBIR/STTR] Radiation Therapy and Biology ‐SETA] GR‐2013‐ 02355540 Deciphering the role of SETD5 in intellectual disabilities and setting a new gene‐on therapeutic strategy. SAN RAFFAELE MILANO Sessa Alessandro Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD GR‐2013‐ 02355541 Periodontal Disease and Arthritis: Development of a Multidisciplinary Unit Toscana Graziani Filippo Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD GR‐2013‐ 02355542 ROLE OF NF‐KB DYNAMICS IN PROGERIA AND AGE‐ RELATED INFLAMMATION SAN RAFFAELE MILANO Zambrano Samuel Biomedica Cellular Mechanisms in Aging and Development ‐ CMAD Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Biology of Development and Aging Classificazione 2° liv. Pagina 22 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO GR‐2013‐ 02355544 Innovative approaches for multiple myeloma microenvironment characterization and B cell‐derived exosomes trapping GR‐2013‐ 02355545 DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Calabria Iaccino Enrico Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME Emilia‐Romagna Turola Elena Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS Tramacere Irene Clinico‐ Healthcare Delivery and assistenzial Methodologies e Biostatistical Methods and Research Design ‐ BMRD An innovative role for serum extracellular membrane vesicles: prognosis and progression of hepatocellular carcinoma (HCC). GR‐2013‐ 02355546 The risk‐benefit profile of pharmacological treatments in CARLO BESTA secondary prevention for patients with ischemic stroke: a systematic review GR‐2013‐ 02355561 Innovative multisensory stimulation system for entraining locomotor circuitry and enhancing gait rehabilitation SANTA LUCIA Sylos Labini Francesca Biomedica Integrative, Functional, and Cognitive Neuroscience Sensorimotor Integration ‐ SMI GR‐2013‐ 02355565 Exploring the role of AMPK pathway in the alteration of hippocampal plasticity in a transgenic mouse model of Alzheimer's Disease SANTA LUCIA Cavallucci Virve Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN GR‐2013‐ 02355568 Istituto Superiore di Sanita' Marconi Analysis of the lipid rafts proteome (raftome) in peri‐ lesional melanocytes as well as in primary and metastatic melanoma cells from the same patient for the identification of new therapeutic targets and markers of tumor progression. Matteo Biomedica Oncology 1 ‐ Basic Translational Tumor Progression and Metastasis ‐ TPM2 GR‐2013‐ 02355576 In vivo chemical screening for modulators of CREB induced myeloid leukemia. Veneto PIGAZZI MARTINA Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB GR‐2013‐ 02355578 Ipsilateral invasive transformation or in situ relapse of ductal breast carcinoma in situ: role of biomarkers (HJURP,TGM2, HIF 1 alpha, Androgen Receptor and miRNAs 9, 210, 200) for prognosis and for prediction of response to radiotherapy Istituto Scientifico Romagnolo Bravaccini Sara Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 23 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02355581 Comprehensive tracking of hematopoietic stem/progenitor cells dynamics and activity in vivo in humans by insertional barcoding SAN RAFFAELE MILANO Biasco Luca Biomedica Genes, Genomes and Genetics Gene Therapy and Inborn Errors ‐ GTIE Special Emphasis Panel GR‐2013‐ 02355585 The role of cellular senescence in the progression from chronic liver inflammation to cancer HUMANITAS Faggioli Francesca Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME GR‐2013‐ 02355616 Autophagy modulation for promoting cell survival and recovery after Spinal Cord Injury. SANTA LUCIA Bisicchia Elisa Biomedica Brain Disorders and Clinical Neuroscience Acute Neural Injury and Epilepsy ‐ ANIE GR‐2013‐ 02355617 Identification of clinically relevant mutation signatures in Abruzzo cutaneous melanoma as potential biomarkers of different molecular subtypes Pellegrini Cristina Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD GR‐2013‐ 02355618 Mechanisms of immuno‐chemoresistance in NOTCH1‐ mutated chronic lymphocytic leukemia: implications for specific target therapies C.R.O. AVIANO Dal Bo Michele Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB GR‐2013‐ 02355619 Remote brain damage: targeting the epigenome as an innovative approach to counteract neurodegeneration. SANTA LUCIA Latini Laura Biomedica Brain Disorders and Clinical Neuroscience Acute Neural Injury and Epilepsy ‐ ANIE GR‐2013‐ 02355622 Feasibility and activity of dietary intervention in head and ISTITUTO TUMORI neck cancer carcinoma survivors: a Phase II multicenter MILANO prospective randomized trial. Bossi Paolo Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Chemo/Dietary Prevention ‐ CDP GR‐2013‐ 02355623 Genetic and epigenetic mechanisms in disordered gambling: an opportunity for the development of new therapeutic strategies MAGGIORE Dell'osso Bernardo Biomedica Brain Disorders and Clinical Neuroscience Pathophysiological Basis of Mental Disorders and Addictions ‐ PMDA GR‐2013‐ 02355625 Dissecting the role of unexplored miR‐205 host gene as a basal cell‐specific long non‐coding RNA in prostate cancer development ISTITUTO TUMORI MILANO Gandellini Paolo Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP GR‐2013‐ 02355627 Fibroblasts as in vitro model for the identification of Treatment‐Resistant Depression (TRD) biomarkers FATEBENEFRATELLI Milanesi Elena Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 24 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02355629 Regeneration of the ocular surface by targeting the Akt2‐ mTORC1 pathway Veneto Elbadawy Hossein Biomedica Cell Biology Molecular and Integrative Signal Transduction ‐ MIST GR‐2013‐ 02355631 MicroRNAs to target cancer stem cells in lung cancer ISTITUTO TUMORI MILANO Boeri Mattia Biomedica Oncology 2 ‐ Translational Clinical Developmental Therapeutics ‐ DT GR‐2013‐ 02355632 Development and pre‐Clinical testing of a novel enzyme replacement therapy for Krabbedisease: aptamer‐ mediated GALC delivery into the central nervous system. STELLA MARIS Cecchini Marco Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN GR‐2013‐ 02355636 NEW DRUGS COMBINATION FOR MALIGNANT PLEURAL MESOTHELIOMA TREATMENT I. O. V. Urso Loredana Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB GR‐2013‐ 02355637 Neutrophil traps in leukemia: from triggers of disease progression to vehicle for new vaccines ISTITUTO TUMORI MILANO Sangaletti Sabina Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME GR‐2013‐ 02355638 Identification of presymptomatic markers in Parkinson's disease SAN RAFFAELE MILANO Piccoli Giovanni Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02355640 Involvement of glia dysfunction in epilepsy: focal down‐ regulation of Kir4.1 channel in rats with cortical dysplasia CARLO BESTA Moroni Ramona Frida Biomedica Brain Disorders and Clinical Neuroscience Acute Neural Injury and Epilepsy ‐ ANIE GR‐2013‐ 02355642 PROTEOMIC PROFILE AND INFLAMMATORY CYTOKINE TO DISCRIMINATE BENIGNE VS BREAST CANCER PATIENTS IN PRESENCE OF MAMMOGRAPHIC SUSPECT ONCOLOGICO DI BARI Garrisi Vito Michele Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02355644 Age‐related hearing loss: from gene identification to a better diagnosis and prevention BURLO GAROFALO Girotto Giorgia Clinico‐ Genes, Genomes and assistenzial Genetics e Genetics of Health and Disease ‐ GHD GR‐2013‐ 02355645 Role of non‐coding RNAs in resistance to targeted therapies in cutaneous melanoma C.R.O. AVIANO Fratta Elisabetta Biomedica Basic Mechanisms of Cancer Therapeutics ‐ BMCT Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Oncology 2 ‐ Translational Clinical Pagina 25 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02355646 Unravelling the pathogenetic pathways in an experimental model of Diabetic Encephalopathy by a omics‐based platform: potential for novel diagnostic and therapeutic interventions Puglia Gnoni Antonio GR‐2013‐ 02355651 High sensitive immunosensors for the detection of foodborne pathogens IZSME DELLA VENTURA BARTOLOMEO Biomedica GR‐2013‐ 02355658 Neuropsychological functioning and brain network organization at the onset of focal childhood epilepsy: implications for early diagnosis and cognitive treatment Istituto Scienze Neurologiche filippini melissa Clinico‐ Integrative, Functional, assistenzial and Cognitive Neuroscience e Neurobiology of Learning and Memory ‐ LAM GR‐2013‐ 02355674 Investigation of molecular mechanisms and possible therapeutic strategies in models of fetalalcohol spectrum disorder and alcohol dependence. Toscana Gerace Elisabetta Biomedica Brain Disorders and Clinical Neuroscience Pathophysiological Basis of Mental Disorders and Addictions ‐ PMDA GR‐2013‐ 02355676 Selective targeting of Glioblastoma cells by drug‐ Veneto functionalized Antibodies and Avidin‐Nucleic‐Acid‐Nano‐ ASsemblies (ANANAS) and in vivo monitoring by Confocal Laser Endomicroscopy (CLE). Persano Luca Biomedica Oncology 2 ‐ Translational Clinical Developmental Therapeutics ‐ DT GR‐2013‐ 02355679 Adenosine A2A receptors as potential therapeutic targets Istituto Superiore di Sanita' Ferrante in Fragile X syndrome Antonella Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND GR‐2013‐ 02355683 Biochemical and molecular basis of multimodal MRI and GASLINI PET metabolic imaging in pediatric gliomas: from biology to clinical implications. Samantha Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02355685 Mass Cytometry Analysis: a new approach to investigate Istituto Superiore di Sanita' Luca key mechanisms in predicting response to chemotherapy in ovarian cancer patients Pasquini Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02355691 In vitro and in vivo analysis of ATP effect in Acute Myeloid Leukemia cells: development of novel therapeutic strategies Valentina Biomedica Oncology 2 ‐ Translational Clinical Developmental Therapeutics ‐ DT Emilia‐Romagna Mascelli Salvestrini Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Biomedica Classificazione 1 Liv. Classificazione 2° liv. Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular Aspects of Diabetes and Obesity ‐ CADO Infectious Diseases and Microbiology Infectious Diseases and Microbiology Fellowship ‐ F13 Pagina 26 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02355698 Pathophysiological and prognostic aspects of Medication Overuse Headache: insight from function Magnetic Resonance Imaging. Umbria Caproni Stefano Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02355700 Targeting cutaneous anti‐apoptotic PI3K/AKT signalling as a new therapeutic approach for treating skin inflammation ISTITUTO DERMOPATICO DELL'IMMACOLATA Madonna Stefania Biomedica Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ‐ ACTS GR‐2013‐ 02355703 Adjuvant properties of plant extract components in anticancer HPV vaccines produced in green biofactories. REGINA ELENA Paolini Francesca Biomedica Oncology 2 ‐ Translational Clinical Oncology 2 ‐ Translational Clinical Small Business [SBIR/STTR] Radiation Therapy and Biology ‐SETA] GR‐2013‐ 02355708 EN: Translational study of the oncogenic role of NPM/ALK in Anaplastic Large Cell Lymphoma (ALCL)IT: Analisi traslazionale del ruolo oncogenico di NPM/ALK in Linfoma Anaplastico a Grandi Cellule (ALCL) Lombardia MAGISTRONI VERA Biomedica Oncology 1 ‐ Basic Translational Cancer Genetics ‐ CG GR‐2013‐ 02355709 EN: Identification of somatic mutations and gene fusions Lombardia by whole‐transcriptome sequencing in acute myeloid leukemiaIT: Identificazione di mutazioni somatiche e fusioni geniche in pazienti affetti da leucemia mieloide acuta tramite sequenziamento dell¿in Redaelli Sara Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP GR‐2013‐ 02355714 Telomerase activated pro‐drugs activated as a novel pharmacological approach to hepatocellular carcinoma treatment. Toscana Tarocchi Mirko Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT GR‐2013‐ 02355717 Hypothalamic control of peripheral immune tolerance: novel model for the study of multiple sclerosis. SANTA LUCIA Procaccini Claudio Biomedica Immunology Hypersensitivity, Autoimmune, and Immune GR‐2013‐ 02355718 Cerebro‐cerebellar connectivity in dynamic resting‐state networks: implications for large‐scale network dysfunction in neurodegenerative diseases. MONDINO Castellazzi Gloria Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Medical Imaging ‐ MEDI Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 27 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02355719 The relevance of non‐coding RNA in the biological and clinical heterogeneity of Multiple Myeloma: a high‐ throughput sequencing approach. MAGGIORE Lionetti Marta Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC GR‐2013‐ 02355720 Mechanisms of HIV‐1 restriction and dissemination mediated by mucosal myeloid cells SAN RAFFAELE MILANO Cavarelli Mariangela Biomedica AIDS and Related Research AIDS Immunology and Pathogenesis ‐ AIP GR‐2013‐ 02355722 Evaluation of a restricted miRNA signature, with REGINA ELENA particular focus on let‐7c, as marker of prognosis, treatment outcome and therapeutic tool in acute myeloid leukemia Pelosi Andrea Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC GR‐2013‐ 02355723 Phenotypic heterogeneity of Alzheimer disease: towards the identification of molecular determinants underlying distinct clinico‐pathological subgroups CARLO BESTA Catania Marcella Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02355724 ULTRASENSITIVE DIAGNOSTIC TEST FOR DEGENERATIVE DEMENTIAS BASED ON AMPLIFICATION OF PERIPHERAL DISEASE‐SPECIFIC BIOMARKERS FROM THE OLFACTORY MUCOSA CARLO BESTA Moda Fabio Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02355728 Melatonin & Resveratrol: a new perspective to correct the RIZZOLI autophagy defect in Duchenne Muscular Dystrophy Pellegrini Camilla Biomedica Cell Biology Cellular Signaling and Regulatory Systems ‐ CSRS GR‐2013‐ 02355730 TSE IN GOATS: STRAINS CHARACTERIZATION AND RISK FOR HUMANS IZSPLV Iulini Barbara Biomedica Veterinary Animal Health ‐ ANHE GR‐2013‐ 02355734 The structural and functional role of EMILIN1 in lymphatic vasculature: prospects for lymphedema treatment with an extracellular matrix protein. C.R.O. AVIANO Pivetta Eliana Biomedica Vascular and Hematology Vascular Cell and Molecular Biology ‐ VCMB Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 28 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02355737 Botulinum toxin and chronic migraine: long‐tem clinical efficacy and epigenetic aspects Umbria Corbelli Ilenia Clinico‐ Emerging Technologies and Pharmacology and assistenzial Training in Neurosciences Diagnostics for e Neuropsychiatric Disorders and Neural Systems Small Business ‐ SBPD GR‐2013‐ 02355744 Intratumoral treatment of unrescatable primary and metastatic solid cancer with Yttrium‐90 microspheres using an orthotopic mouse model of pancreatic adenocarcinoma PASCALE Barbieri Antonio Biomedica Oncology 2 ‐ Translational Clinical Oncology 2 ‐ Translational Clinical Small Business [SBIR/STTR] Radiation Therapy and Biology ‐SETA] GR‐2013‐ 02355746 Identification of new NCX activators as neuroprotective agents in cerebral ischemia SDN Cuomo Ornella Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND GR‐2013‐ 02355747 Chemosensitizing action of voacamine on in vitro and in vivo multidrug resistant tumor models Istituto Superiore di Sanita' Condello Maria Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT GR‐2013‐ 02355751 Identification and function of novel biomarkers in bone metastatic tumors RIZZOLI CARINA VALERIA Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME GR‐2013‐ 02355756 Dynamics and metabolic pathways leading to immune‐ regulation in Multiple Sclerosis. SANTA LUCIA Sambucci Manolo Biomedica Immunology Hypersensitivity, Autoimmune, and Immune GR‐2013‐ 02355758 Exploiting xenograft tumor models to predict response to Lombardia molecular targeted therapies in advanced epithelial ovarian cancer Fruscio Robert Biomedica Oncology 2 ‐ Translational Clinical Drug Discovery and Molecular Pharmacology ‐ DMP GR‐2013‐ 02355759 Purinergic P2X7 receptor modulation as a novel therapeutic strategy against Amyotrophic Lateral Sclerosis Apolloni Savina Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN SANTA LUCIA Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 29 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02355760 Causative role of epigenetic dysregulation in inducing resistance to immunomodulatory drugs (IMiDs): implications for the therapeutic targeting of IMiDs‐ resistant Diffuse Large B‐cell Lymphoma (DLBCL) with DNA methyltransferase inhibitors (DNMTIs) in comb HUMANITAS LOCATELLI GR‐2013‐ 02355763 Hematologic manifestations in mitochondrial disorders: characterization, etiology, and pathogenesis. OSPEDALE BAMBINO GESU' EMMANUELE VALENTINA Biomedica GR‐2013‐ 02355765 VIOLENCE AGAINST WOMEN AND EMERGENCY HEALTH SERVICES: a controlled trial to compare different training programmes for health workers FATEBENEFRATELLI Dagani Jessica Clinico‐ Risk, Prevention and assistenzial Health Behavior e SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan ‐ TPM1 GR‐2013‐ 02355766 Il Sorveglia Paziente (The Patient Monitor) RIZZOLI Falcioni Stefano Clinico‐ Population Sciences and assistenzial Epidemiology e Social Sciences and Population Studies ‐ SSPS GR‐2013‐ 02355770 Genetic predisposition in acquired thrombotic thrombocytopenic purpura MAGGIORE Mancini Ilaria Biomedica Immunology Hypersensitivity, Autoimmune, and Immune GR‐2013‐ 02355771 The development of a tissue‐engineered prosthesis using decellularized blood vessels andautologous stem cells Sardegna mancuso luisa Biomedica Bioengineering Sciences and Technologies Biomaterials and Biointerfaces ‐ BMBI GR‐2013‐ 02355772 MUTUAL INTERACTION OF OSTEOARTHRITIC INFLAMMATORY MICROENVIRONMENT AND BIOTECHNOLOGIES RIZZOLI Veronesi Francesca Biomedica Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ‐ ACTS GR‐2013‐ 02355779 Growth Associated Protein 43 (GAP43) and Major Histocompatibility Complex I (MHCI) gene delivery to spinal motor neurons to prevent the progression of Amyotrophic Lateral Sclerosis (ALS) MARIO NEGRI Nardo Giovanni Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02355780 In vitro and in vivo effects of static magnetic fields on the NEUROLESI orientation of erythrocytes, in order to define people exposure risk: modeling and simulation Acri Giuseppe Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences ‐ BTSS Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. SILVIA LAURA Biomedica Classificazione 1 Liv. Classificazione 2° liv. Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD Pagina 30 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE Classificazione 1 Liv. Classificazione 2° liv. GR‐2013‐ 02355783 The impact of light on food craving and mood: prediction Veneto of circadian rhythm disorders from next generation sequencing data. Minervini Giovanni Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD GR‐2013‐ 02355784 Identification of mitochondrial DNA somatic alteration in Basilicata myelodysplastic syndromes and in other hematological malignancies: clinical impact and correlation with exome "status". Scarciolla Oronzo Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC GR‐2013‐ 02355786 A New Nanostructured Biomaterial for Vaginal Infections Marisa Biomedica Bioengineering Sciences and Technologies Nanotechnology ‐ NANO GR‐2013‐ 02355793 C.R.O. AVIANO Stereotactic Ablative Radiotherapy (SABR) for Oligometastatic Breast Cancer Patients: Investigating the Immune Profile to Identify Predictive Biomarkers. Trovò Marco Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Radiation Therapeutics and Biology ‐ RTB GR‐2013‐ 02355796 Antimicrobial drug resistance in food‐producing animals. IZSPLV Essential oils and supercritical fluid extraction: study the antimicrobial and immuno‐stimulating activity in livestock for reducing the use of antibiotics and environmental pollution, improvement o Barbero Raffaella Biomedica Veterinary Animal Health ‐ ANHE GR‐2013‐ 02355798 Prognostic factors and diagnostic tools for the management of Dengue Fever: role of Iterleukin‐28 and diagnosis in urine sample in a cohort of patients with acute dengue. SPALLANZANI Vairo Francesco Biomedica Infectious Diseases and Microbiology Clinical Research and Field Studies of Infectious Diseases ‐ CRFS GR‐2013‐ 02355801 Unraveling the etiology of breast cancer: the viral component of a complex disease ‐ BRAVE Emilia‐Romagna Fusco Daniela Biomedica Population Sciences and Epidemiology Epidemiology of Cancer ‐ EPIC GR‐2013‐ 02355803 Tears as source of new molecular biomarkers of multiple sclerosis: a metabolomics study Abruzzo Pieragostino Damiana Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02355804 Phenotypic and functional characterization of mait cells in hepatocellular carcinoma: a target for novel immunotherapeutic approaches Sicilia Buccheri Simona Biomedica Immunology Transplantation, Tolerance and Tumor Immunology ‐ TTT Istituto Superiore di Sanita' Colone Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Pagina 31 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02355806 Abruzzo Assessments of the response of human chronic lymphocytic leukemia cells after enhanced expression of miRs‐181b/a and miR‐130a in murine models of human CLL GR‐2013‐ 02355808 Development of a new nerve repair strategy, combining collagen VI‐coated conduits and adipose‐derived stem cells. GR‐2013‐ 02355811 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Visone Rosa Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC Veneto Cescon Matilde Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences ‐ BTSS A psychosocial intervention centered on dignity (Dignity Therapy) in patients with advanced cancer. Emilia‐Romagna Nanni Maria Giulia Clinico‐ Risk, Prevention and assistenzial Health Behavior e Behavioral Medicine: Interventions and Outcomes ‐ BMIO GR‐2013‐ 02355820 IDENTIFICATION AND TESTING OF NOVEL 'DRUGGABLE' THERAPEUTIC TARGETS CAPABLE OF DRIVING ENDOGENOUS NEURAL STEM CELLS TO PROMOTE CENTRAL NERVOUS SYSTEM TISSUE REPAIR IN EXPERIMENTAL SPINAL CORD INJURY SAN RAFFAELE MILANO cusimano melania Biomedica Brain Disorders and Clinical Neuroscience Acute Neural Injury and Epilepsy ‐ ANIE GR‐2013‐ 02355827 Exploring the functional link between alpha‐synuclein Umbria and beta‐glucocerebrosidase within the global autophagy‐ lysosomal network: relevance for early diagnosis and pharmacological treatment in Parkinson's disease Chiasserini Davide Biomedica Biology of Development and Aging Cellular Mechanisms in Aging and Development ‐ CMAD GR‐2013‐ 02355830 Understanding excitotoxic neurodegeneration and disability progression in human and experimental multiple sclerosis NEUROMED Rossi Silvia Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT GR‐2013‐ 02355833 Targeting PTEN‐Loss in Colorectal Cancer Stem cells with combined inhibition of the MAPK and PI3K pathways REGINA ELENA Ciuffreda Ludovica Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB GR‐2013‐ 02355837 Decision‐making and impulse control impairments in alcohol dependence: assessment of cognitive precursors, and development of a neuro‐cognitive treatment MAUGERI canessa nicola Biomedica Brain Disorders and Clinical Neuroscience Neural Basis of Psychopathology, Addictions and Sleep Disorders ‐ NPAS Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 32 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02355838 Linking the immune system to cortical excitability in multiple sclerosis: implications for epilepsy and sleep NEUROMED ALBANESE MARIA Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT GR‐2013‐ 02355842 Unravelling the cellular pathways associated with uromodulin mutations to identify new therapeutic strategies for tubulointerstitial renal disorders SAN RAFFAELE MILANO SCHAEFFER Celine Biomedica Digestive, Kidney and Urological Systems Cellular and Molecular Biology of the Kidney ‐ CMBK GR‐2013‐ 02355843 Retinoic acid and hypoxia signaling in acute myeloid leukemia as a new axis for therapeutic intervention SAN RAFFAELE MILANO Coltella Nadia Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT GR‐2013‐ 02355870 Molecular and functional characterization of circulating and tissue‐infiltrating Th1/17 cells in Multiple Sclerosis. MAGGIORE Paroni Moira Biomedica Immunology Cellular and Molecular Immunology A ‐ CMIA GR‐2013‐ 02355876 Exploring synaptic plasticity through non‐invasive brain stimulation to understand the mechanisms of disease progression in Multiple Sclerosis SANTA LUCIA Mori Francesco Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT GR‐2013‐ 02355879 Preclinical evaluation of enhanced cell killing in prostate cancer through combinational targeting with antibody‐ guided toxin(s) and pharmaceutical drugs. Veneto Pasetto Matteo Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB GR‐2013‐ 02355882 Inducible pluripotent stem (iPS) cell‐derived human astrocytes as a new disease model to shed light into the molecular pathogenesis of megalencephalic leukoencephalopathy with subcortical cysts (MLC). Istituto Superiore di Sanita' Lanciotti Angela Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02355887 SANTA LUCIA Childhood maltreatment and risk for depression: a preclinical longitudinal study to uncover new therapeutic targets and early predictive biomarkers Luisa Biomedica Brain Disorders and Clinical Neuroscience Neural Basis of Psychopathology, Addictions and Sleep Disorders ‐ NPAS Lo Iacono Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 33 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02355894 Neurobiological modulators of aberrant motivation: promising targets of treatment and prevention in psychopathology SANTA LUCIA Latagliata Emanuele Claudio Biomedica Brain Disorders and Clinical Neuroscience Pathophysiological Basis of Mental Disorders and Addictions ‐ PMDA GR‐2013‐ 02355895 A new mouse model for Glycogen Storage Disease type 1b: an indispensable tool to understand the pathophisiology of the disease and to develop new therapies. GASLINI Resaz Roberta Biomedica Genes, Genomes and Genetics Therapeutic Approaches to Genetic Diseases ‐ TAG GR‐2013‐ 02355897 Relationship between cognitive reserve and cognitive impairment in epilepsy: a study of cortical plasticity and functional connectivity by transcranial magnetic stimulation Toscana Giovannelli Fabio Clinico‐ Integrative, Functional, assistenzial and Cognitive Neuroscience e Cognitive Neuroscience ‐ COG GR‐2013‐ 02355900 Predicting microRNA‐based therapies by using gene expression data driven microRNA‐mRNA interactome Sicilia Coronnello Claudia Biomedica Genes, Genomes and Genetics Genomics, Computational Biology and Technology ‐ GCAT GR‐2013‐ 02355901 Neurodegeneration and protein misfolding in HIV‐ associated neurocognitive disorder: understanding the functional role of HIV‐1 matrix protein p17 to design novel therapeutic interventions. MARIO NEGRI CACCURI FRANCESCA Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02355902 Inhibition of protein kinase CK1a as a novel therapeutic strategy to target multiple myeloma progression and the associated bone disease Veneto Manni Sabrina Biomedica Oncology 2 ‐ Translational Clinical Drug Discovery and Molecular Pharmacology ‐ DMP GR‐2013‐ 02355905 New frontiers for early intervention of language disorders: neural and genetic markers of risk in infants MEDEA Cantiani Chiara Biomedica Integrative, Functional, and Cognitive Neuroscience Cognitive Neuroscience ‐ COG GR‐2013‐ 02355906 MERESSINA 2.0 ‐ upgrading the novel MEchatronic REspiratory System SImulator for Neonatal Application Toscana Ciantelli Massimiliano Clinico‐ Bioengineering Sciences assistenzial and Technologies e Instrumentation and Systems Development ‐ ISD GR‐2013‐ 02355909 Modelling Classical Scrapie spread in the Italian sheep population: enhancement the effectiveness of control policies Istituto Superiore di Sanita' Baldinelli Francesca Biomedica Animal Health ‐ ANHE Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Veterinary Classificazione 2° liv. Pagina 34 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02355918 Identification of genetic causes and molecular mechanisms for MSA syndrome GR‐2013‐ 02355921 Dissecting the role of SLC15A4 in autoimmune peripheral SAN RAFFAELE MILANO neuropathies. GR‐2013‐ 02355925 ADA2 Deficiency: a new model of disease to study pathogenic mechanisms of autoinflammation and immunodeficiency GR‐2013‐ 02355926 Friuli‐Venezia Giulia Impact of the application of GLIADEL wafers (BCNU, carmustine) followed by temozolomide and radiotherapy in patients with glioblastoma multiforme: efficacy, toxicity and a stem‐cell model to predict response/resistance to therapy. GR‐2013‐ 02355927 EXOSOME‐ASSOCIATED ADAM17 AS A NEW ANTI‐ HIV‐1 THERAPEUTIC TARGET GR‐2013‐ 02355930 AREA P.I. Cell Death in Neurodegeneration ‐ CDIN Biomedica Cell Biology Membrane Biology and Protein Processing ‐ MBPP FRANCESCA Biomedica Immunology Cellular and Molecular Immunology A ‐ CMIA Tamara Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC Istituto Superiore di Sanita' Arenaccio Claudia Biomedica AIDS Immunology and Pathogenesis ‐ AIP Trajectories of Health and Social Care Integration (THESIs): An Action‐Research on the Challenges from Chronic Neurological Disease for Society, Health Organizations and Professionals. Emilia‐Romagna LUSARDI ROBERTO Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD GR‐2013‐ 02355932 Dissecting the molecular basis of SEPN1‐related‐ myopathies MARIO NEGRI Zito Ester Biomedica Cell Biology Molecular and Integrative Signal Transduction ‐ MIST GR‐2013‐ 02355936 From gene to therapy in Amyotrophic Lateral Sclerosis: focus on endothelin system. Associazione Oasi Maria SS D'Antoni Simona Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GASLINI Alessio Barnaba Biomedica Romano Alessandro SCHENA Ius Classificazione 2° liv. Brain Disorders and Clinical Neuroscience MAGGIORE Di Fonzo Classificazione 1 Liv. Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AIDS and Related Research Pagina 35 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02355938 Discovery of the mutations associated with the aggressiveness of High Risk Neuroblastoma (HR‐NB) patients using Whole Exome Sequencing: mutation analysis for the increased prediction of relapse in HR‐NB patients Veneto ESPOSITO MARIA ROSARIA Biomedica Oncology 1 ‐ Basic Translational Cancer Genetics ‐ CG GR‐2013‐ 02355939 Preclinical and clinical investigation of molecular chaperones modulation as a new therapeutic strategy for Parkinson's disease. MONDINO Ambrosi Giulia Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02355942 Exploiting patient‐derived tumor xenografts to predict response and circumvent the occurrence of resistance to anti‐angiogenesis treatments in ovarian cancer. MARIO NEGRI Decio Alessandra Agnese Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME GR‐2013‐ 02355945 Development of Nerve Growth Factor antagonists to treat SAN RAFFAELE MILANO allergy: in vitro and in vivo evaluation of novel molecules. Sacchetti Marta Biomedica Immunology Hypersensitivity, Autoimmune, and Immune GR‐2013‐ 02355946 Extracellular matrix dynamics in Hepatitis C‐induced SPALLANZANI liver fibrosis: towards a proteomic atlas of the fibrotic liver Montaldo Claudia Biomedica Infectious Diseases and Microbiology Infectious Diseases and Microbiology Fellowship ‐ F13 GR‐2013‐ 02355953 Molecular determinants of interactions between B‐ Chronic Lymphocitic Leukemia cells and its host microenvironment: pathophysiology and novel therapeutic approaches. IRCCS AOU San Martino‐ IST (Genova) Fiz Francesco Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME GR‐2013‐ 02355961 Setup of a multi‐site radiation dose management system for the optimization of radiological procedures and the assessment of individual and collective radiation dose. I. O. V. Gabusi Michele Clinico‐ Healthcare Delivery and assistenzial Methodologies e Biomedical Computing and Health Informatics ‐ BCHI GR‐2013‐ 02355964 Cell‐based therapy with sphingosine 1‐phosphate receptor Emilia‐Romagna 1 (S1PR1)‐expressing macrophages for multiple sclerosis Vinet Jonathan Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT GR‐2013‐ 02355966 Dissecting the genetic and epigenetic bases responsible for congenital diseases of aberrant growth PALUMBO ORAZIO Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD CASA SOLLIEVO SOFFERENZA Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 36 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02355967 Prognostic and predictive values of tumor infiltrating lymphocytes in patients with ductal carcinoma in situ of the breast. I.E.O. LAZZERONI MATTEO Clinico‐ Population Sciences and assistenzial Epidemiology e Epidemiology of Cancer ‐ EPIC GR‐2013‐ 02355968 Human corneal endothelium: reconstruction, regeneration and therapies Veneto Parekh Mohit Biomedica Brain Disorders and Clinical Neuroscience Anterior Eye Disease ‐ AED GR‐2013‐ 02355970 Functional role of miRNA‐binding SNPs on susceptibility CASA SOLLIEVO and clinical outcome of pancreatic cancer SOFFERENZA Tavano Francesca Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02355972 Role of mitochondria in Bipolar Disorders: a proteomic approach SANTA LUCIA Ciregia Federica Biomedica Molecular, Cellular, and Developmental Neuroscience Neural Oxidative Metabolism and Death ‐ NOMD GR‐2013‐ 02355974 Targeting high proliferating tumors: 4‐oxo‐4‐HPR derivatives in the treatment of triple negative breast cancer and lymphoma ISTITUTO TUMORI MILANO Tiberio Paola Biomedica Oncology 2 ‐ Translational Clinical Drug Discovery and Molecular Pharmacology ‐ DMP GR‐2013‐ 02355976 Targeting the extracellular PSMA domain by a radiolabeled antibody fragment (123I‐scFvD2B) for Prostate cancer imaging: a pilot Phase I clinical study ISTITUTO TUMORI MILANO Frigerio Barbara Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02355978 Innovative strategies to target IL17‐producing T cells during airway infections in Cystic Fibrosis disease SAN RAFFAELE MILANO Lorè Nicola Ivan Biomedica Infectious Diseases and Microbiology Host Interactions with Bacterial Pathogens ‐ HIBP GR‐2013‐ 02355980 Development of a customized numerical tool to optimize GALEAZZI implant designs and positioning total knee arthroplasties Pianigiani Silvia Biomedica Bioengineering Sciences and Technologies Modeling and Analysis of Biological Systems ‐ MABS GR‐2013‐ 02355984 Study of systems for evaluating and decreasing potential risks arising from human consumption of edible insects in order to develop food policies and achieve consumer protection. IZSVE Belluco Simone Biomedica Veterinary Food Safety ‐ FOSA GR‐2013‐ 02355986 Promote social interactions and cooperation in Autism via enhanced sharing of motor intentions: the role of reward and oxytocin. SANTA LUCIA Candidi Matteo Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 37 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02355988 Multi‐functionalized nanostructured biomaterials for the CASA SOLLIEVO regeneration of nervous tissues SOFFERENZA GR‐2013‐ 02355990 From deciphering biological networks of cardiosphere‐ derived‐cells (CDC) paracrine activity to cell‐free therapies for cardiac regeneration after myocardial infarction (MI). GR‐2013‐ 02355991 AREA P.I. Biomedica Classificazione 1 Liv. Classificazione 2° liv. Bioengineering Sciences and Technologies Nanotechnology ‐ NANO Cardiovascular and Respiratory Sciences Myocardial Ischemia and Metabolism ‐ MIM Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD Marco Biomedica Musculoskeletal, Oral and Skin Sciences Musculoskeletal Tissue Engineering ‐ MTE Valle Andrea Biomedica Immunology Hypersensitivity, Autoimmune, and Immune Toscana Corsini Iuri Biomedica Digestive, Kidney and Urological Systems Gastrointestinal Mucosal Pathobiology ‐ GMPB Role of oxidative stress in a model of early Alzheimer's Disease: effects of the CoQ10 and environmental enrichment SANTA LUCIA De Bartolo Paola Biomedica Biobehavioral and Behavioral Processes Adult Psychopathology and Disorders of Aging ‐ APDA GR‐2013‐ 02356007 Auditory and olfactory neurodegeneration: chemotherapy side effects and stem cell repair Veneto ASTOLFI LAURA Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND GR‐2013‐ 02356008 Genomic profiling of hepatocellular carcinoma for cancer PASCALE vaccine development Tagliamonte Maria Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII Gelain Fabrizio GAETANI MASSIMILIANO Biomedica Strategies for preserving the integrity and function of the SANTA LUCIA immature brain: a pre‐clinical study. Foti Francesca GR‐2013‐ 02355993 Preclinical optimization of bone‐marrow concentrate treatment to improve osteochondral repair RIZZOLI Cavallo GR‐2013‐ 02355995 Longitudinal high‐definition mapping of circulating immune cells in human autoimmune Type 1 Diabetes SAN RAFFAELE MILANO GR‐2013‐ 02355998 Role of inflammatory response in Necrotizing Enterocolitis of the preterm infants: effectiveness of Toll‐ like receptor 4 antagonist and PPAR gamma agonist tested in an animal model. GR‐2013‐ 02356004 Sicilia Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 38 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02356009 Novel Roles for the Parkinson's Disease kinase LRRK2 in Cytoskeletal Dynamics GR‐2013‐ 02356010 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Civiero Laura Biomedica A new arthroscopic regenerative treatment to target knee RIZZOLI osteoarthritis: evaluation of bone marrow concentrate potential from in vitro studies to the clinical application in a randomized controlled trial. Filardo Giuseppe Clinico‐ Musculoskeletal, Oral and assistenzial Skin Sciences e Arthritis, Connective Tissue and Skin ‐ ACTS GR‐2013‐ 02356012 Fear memory extinction: from animals to humans Laricchiuta Daniela Biomedica Biobehavioral and Behavioral Processes Biobehavioral Mechanisms of Emotion, Stress and Health ‐ MESH GR‐2013‐ 02356016 Use of Silk fibroin nanofibres for the in vivo regeneration SAN RAFFAELE MILANO of urological tissues and the delivery of chemotherapeutic agents Alessandrino Antonio Biomedica Bioengineering Sciences and Technologies Biomaterials and Biointerfaces ‐ BMBI GR‐2013‐ 02356019 Dissecting the Thyroid hormone‐FOXE1 functional link for the development of novel therapeutic approaches in BCC therapy Antonini Dario Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC GR‐2013‐ 02356022 GALEAZZI CRAS ‐ Controlled Release of Adipose‐derived stem cell Secretome in the osteoarthritic joint: one step beyond cell therapy de Girolamo Laura Biomedica Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ‐ ACTS GR‐2013‐ 02356025 Transcranial Magnetic Stimulation in the assessment of motor cortex excitability and experimental treatment of restless legs syndrome. Giuseppe Biomedica Brain Disorders and Clinical Neuroscience Neural Basis of Psychopathology, Addictions and Sleep Disorders ‐ NPAS GR‐2013‐ 02356026 Clinical impact of Next Generation Sequencing analysis Emilia‐Romagna of genetic and epigenetic modifications in head and neck oral squamous cell carcinoma asioli sofia Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS GR‐2013‐ 02356028 Unravel the functional role and the therapeutic potential Veneto of sclera stem cell in glaugoma Bifari Francesco Biomedica Anterior Eye Disease ‐ AED S.CAMILLO SANTA LUCIA SDN Associazione Oasi Maria SS Lanza Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Molecular, Cellular, and Developmental Neuroscience Brain Disorders and Clinical Neuroscience Synapses, Cytoskeleton and Trafficking ‐ SYN Pagina 39 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02356029 Role of 5‐alpha reductase in the impact of sleep disorders Sardegna on tic severity in Tourette syndrome GR‐2013‐ 02356033 STEM CELL NICHE AND TUMOR ASSOCIATED MACROPHAGES: A POTENTIAL THERAPEUTIC TARGET IN CHOLANGIOCARCINOMA GR‐2013‐ 02356038 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Frau Roberto Biomedica Brain Disorders and Clinical Neuroscience Neural Basis of Psychopathology, Addictions and Sleep Disorders ‐ NPAS HUMANITAS Raggi Chiara Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME A NEW ALGORITHM FOR THE EARLY IDENTIFICATION AND TREATMENT OF B‐LINEAGE ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS WITHOUT KNOWN MOLECULAR ABERRATIONS, WHO MAY BENEFIT FROM MOLECULARLY‐DRIVEN THERAPEUTIC APPROACHES Lazio Messina Monica Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02356039 Vaginal infections in HPV‐positive cancer: prevention and treatment based on an integrated approach with natural substances.Acronym: I.N.S.T.IN.C.T (Integration of Natural Substances Toward INfection in Cervical Tumours) Istituto Superiore di Sanita' DI VITO MAURA Biomedica Infectious Diseases and Microbiology Clinical Research and Field Studies of Infectious Diseases ‐ CRFS GR‐2013‐ 02356041 Puglia A system biology study investigating the mechanisms involved in the reduction of cardiovascular risk in dialysis patients treated by high efficiency convective therapy: looking for a therapeutic target for dialysis‐associated cardiovascular disease. Simone Simona Biomedica Cardiovascular and Respiratory Sciences Clinical and Integrative Cardiovascular Sciences ‐ CICS GR‐2013‐ 02356043 SANTA LUCIA A comprehensive preventive program for dementia tailored on the neuropsychological profile of persons with Mild Cognitive Impairment: cognitive stimulation, physical intervention and healthy nutrition, a randomized controlled trial. DI SANTO SIMONA GABRIELLA Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02356044 SANTA LUCIA Chronic lithium treatment in an animal model of early Alzheimer's Disease: characterization of neuroanatomical and functional effects Gelfo Francesca Biomedica Clinical Neuroscience and Neurodegeneration ‐ CNN Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Brain Disorders and Clinical Neuroscience Pagina 40 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02356045 DUNGEON: hacking the functional architecture of Glioblastoma multiforme to curb cellular invasion CASA SOLLIEVO SOFFERENZA Mazza Tommaso Biomedica Genes, Genomes and Genetics Genomics, Computational Biology and Technology ‐ GCAT GR‐2013‐ 02356046 Advanced engineered prostheses for customized treatment of thoracic deformities Toscana Ghionzoli Marco Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences ‐ BTSS GR‐2013‐ 02356050 Imaging cognitive remediation in first episode schizophrenia: a randomized controlled trial SANTA LUCIA Piras Fabrizio Biomedica Brain Disorders and Clinical Neuroscience Neural Basis of Psychopathology, Addictions and Sleep Disorders ‐ NPAS GR‐2013‐ 02356052 Effects of physical exercise on the pathophysiology of cerebellar dysfunction in experimental Multiple Sclerosis SANTA LUCIA GENTILE ANTONIETTA Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT GR‐2013‐ 02356053 Functional characterization of mutations of the gene encoding the cyclin‐dependent kinase inhibitor p27kip1 (CDKN1B), responsible for the development of multiple endocrine neoplasia type 4 (MEN4) syndrome Toscana Francesca Marini Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC GR‐2013‐ 02356055 DEVELOPMENT OF MULTIFACTORIAL GENETIC PREDICTORS OF PHARMACOLOGICAL TREATMENT RESPONSE IN PATIENTS WITH SCHIZOPHRENIA Puglia Pergola Giulio Biomedica Brain Disorders and Clinical Neuroscience Neural Basis of Psychopathology, Addictions and Sleep Disorders ‐ NPAS GR‐2013‐ 02356056 CROB ROLE OF MITOCHONDRIAL OXIDATIVE METABOLISM AND REDOX SIGNALING IN ADULT STEM CELL PROLIFERATION AND DIFFERENTIATION: DEVELOPMENT OF INNOVATIVE STRATEGIES FOR EX VIVO HEMATOPOIETIC STEM CELL EXPANSION TO BE USED IN ONCO‐HEMATOLOGICAL THERAPIES Tataranni Tiziana Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 41 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02356060 Economic crisis and adherence to the Mediterranean diet: possible impact on biomarkers of inflammation and metabolic phenotypes in the cohort of the MOLI‐SANI study. Molise Bonaccio Marialaura Biomedica Healthcare Delivery and Methodologies Health and Health Related Behavior of Individuals and Populations Fellowship ‐ F16 GR‐2013‐ 02356062 Creatine Transporter Deficiency: therapeutic preclinical strategies in a conditional mouse model. STELLA MARIS Casarano Manuela Rita Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD GR‐2013‐ 02356065 COSMO ‐ COntinuum in active Sensory‐MOtor human prosthesis interaction SANTA LUCIA PARADISI FRANCESCO Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Small Business Bioengineering, Surgical Sciences, and Technology ‐ SBTS (SBIR/STTR) GR‐2013‐ 02356066 MONZINO Impact of improvement in systolic and diastolic left ventricular parameters on health‐related quality of life in patients undergoing transcatheter aortic valve implantation: correlations among immediate and long‐ standing echocardiographic changes, heart f Gripari Paola Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS GR‐2013‐ 02356067 Bio‐production and characterization of an array of nanoparticles, made of polysaccharide‐metal hybrid matrices, possessing chemotherapeutic properties. Sicilia Gallo Giuseppe Biomedica Bioengineering Sciences and Technologies Nanotechnology ‐ NANO GR‐2013‐ 02356069 PRECISION MEDICINE FOR CHEMOTHERAPY‐ TREATED BREAST CANCER PATIENTS: ROLE OF PI3KC2A LOSS IN PREDICTING RESPONSE TO ANTI‐ MICROTUBULE DRUGS Piemonte Marchiò Caterina Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02356076 Emilia‐Romagna DEFINITION OF THE PHENOTYPIC STATE‐ DEPENDENT IMPACT OF PERICYTES IN CANCER CELL DISSEMINATION Mangieri Domenica Biomedica Oncology 1 ‐ Basic Translational Tumor Progression and Metastasis ‐ TPM2 GR‐2013‐ 02356082 Characterization of the molecular mechanism of action of Istituto Superiore di Sanita' Shytaj auranofin and buthionine sulfoximine, a scalable drug combination showing curative potential in the macaque AIDS model. Iart Luca Biomedica AIDS and Related Research AIDS Discovery and Development of Therapeutics ‐ ADDT Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 42 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO GR‐2013‐ 02356085 Role of gene expression regulation in autophagy‐ mediated chemoresistance in brain tumours GR‐2013‐ 02356091 DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagliarini Vittoria Biomedica Genes, Genomes and Genetics Molecular Genetics ‐ MGA Emilia‐Romagna Single cell analysis by multiparameter flow cytometry: indentification of new markers for response and immune characterisazion of multpile myeloma patients treated with new drugs Brioli Annamaria Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02356092 Prognostic significance of the quantification of disease and mutations using Peptide Nucleic Acids in Chronic Myeloid Leukemia precursors at diagnosis and after 3 months of treatment with Tyrosine Kinase Inhibitors Piemonte Fava Carmen Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT GR‐2013‐ 02356093 Learning and Relearning Math S.CAMILLO Benavides‐ Varela Silvia Clinico‐ Biobehavioral and assistenzial Behavioral Processes e Cognition and Perception ‐ CP GR‐2013‐ 02356116 Circulating tumor cells in squamous cervical cancer: impact on survival and molecular characteristics responsible of tumor progression and spread. REGINA ELENA tomao federica Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02356126 FROM CELIAC DISEASE TO ENTEROPATHY‐ MAGGIORE ASSOCIATED T CELL LYMPHOMA : miRNAs AS NOVEL PREDICTIVE BIOMARKERS OF MALIGNANT TRANSFORMATION Tomba Carolina Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02356129 Cardiac troponin after cardiac surgery SAN RAFFAELE MILANO Monaco Fabrizio Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Surgery, Anesthesiology, and Trauma ‐ SAT GR‐2013‐ 02356132 Personality influence on different trajectories of morphological changes in neurodegenerative disease. SANTA LUCIA Picerni Eleonora Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02356134 Evaluation of the use of silver nanoparticles to reduce zoonotic food‐borne infections (Salmonella and Campylobacter) in the egg producing farms: assessment of efficacy and benefit‐to‐risk analysis IZSVE Losasso Carmen Biomedica Veterinary Food Safety ‐ FOSA SANTA LUCIA Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 43 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02356138 RNA transcriptional profiling of oral squamous cell carcinoma to identify reliable prognostic and predictive markers for routine clinical practice. Piemonte Arduino Paolo Giacomo Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02356150 Effectiveness of testosterone replacement therapy (TRT) on prostatic gland in hypogonadal patients affected by benign prostatic hyperplasia (BPH) and metabolic syndrome (MetS) Toscana Vignozzi Linda Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Integrative and Clinical Endocrinology and Reproduction ‐ ICER GR‐2013‐ 02356154 Expanding the spectrum of immunotherapy‐responsive DON GNOCCHI epilepsy: identification of novel neuronal surface antibodies and characterization of their target antigens in patients with antiepileptic‐drug resistant epilepsy Iorio Raffaele Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT GR‐2013‐ 02356155 Targeting aortic valve calcification: role and therapeutic potential of pyrophosphate. Rattazzi Marcello Biomedica Vascular and Hematology Atherosclerosis and Inflammation of the Cardiovascular System ‐ AICS GR‐2013‐ 02356156 The use of satellite data to estimate the short‐term health Lazio effects of air pollution in proximity of industrial sites in Italy Badaloni Chiara Clinico‐ Population Sciences and assistenzial Epidemiology e Social Sciences and Population Studies ‐ SSPS GR‐2013‐ 02356158 METABOLIC COMORBIDITIES IN PATIENTS WITH CHRONIC URTICARIA caldarola giacomo Biomedica Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ‐ ACTS GR‐2013‐ 02356172 Toscana Defining the expression profiles of microRNAs in pancreatic islets, in immune cell infiltrates and in serum samples of NOD mice and in sera of type 1 diabetic patients: a role for microRNAs as candidate biomarkers of autoimmune diabetes Sebastiani Guido Biomedica Immunology Hypersensitivity, Autoimmune, and Immune GR‐2013‐ 02356174 Venous thromboembolism in patients with hepatocellular MAGGIORE carcinoma undergoing liver transplantation. maino alberto Clinico‐ Vascular and Hematology assistenzial e Veneto Lazio Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Hemostasis and Thrombosis ‐ HT Pagina 44 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02356175 The role of inflammation in mood disturbances in multiple sclerosis NEUROMED BUTTARI FABIO Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT GR‐2013‐ 02356179 Mitochondrial calcium signaling in the control of insulin sensitivity Veneto De Stefani Diego Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular Aspects of Diabetes and Obesity ‐ CADO GR‐2013‐ 02356183 The role of endothelial dysfunction in venous thromboembolism (VTE): data from the population‐ based Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) Study Emilia‐Romagna Cattabiani Chiara Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR GR‐2013‐ 02356193 I. O. V. STRUCTURAL AND FUNCTIONAL INSIGHTS FOR POST‐TRANSLATIONAL MODIFICATIONS IN CANCER: INVESTIGATING NEW TARGETABLE PLAYERS molon barbara Biomedica Immunology Transplantation, Tolerance and Tumor Immunology ‐ TTT GR‐2013‐ 02356194 Identification of novel genes involved in Non‐Syndromic Intellectual Disability. A first step for new diagnostic tools and potential therapeutic targets. BURLO GAROFALO Faletra Flavio Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD GR‐2013‐ 02356198 ROLE OF EPHA3 AS POTENTIAL MOLECULAR TARGET IN MULTIPLE MYELOMA: IN VITRO AND IN VIVO EFFECTS OF A SPECIFIC MONOCLONAL ANTIBODY CROB Caivano Antonella Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB GR‐2013‐ 02356217 Combination of novel acellular nerve allografts and autografts as a complex nerve repair. Preclinical and postsurgical evaluation of nerve regeneration and Schwann cell migration. RIZZOLI Boriani Filippo Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Surgery, Anesthesiology, and Trauma ‐ SAT GR‐2013‐ 02356223 Lazio Multidisciplinary project to optimize management and improving survival of patients with severe sepsis or septic shock due to multidrug‐resistant microrganisms. FALCONE MARCO Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 45 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02356227 Ectodermal dysplasia syndromes by defective nectins (nectinopathies): molecular mechanisms and clinical implications ISTITUTO DERMOPATICO DELL'IMMACOLATA Brancati Francesco Biomedica GR‐2013‐ 02356238 Development of an integrated database and space‐time statistical methodology to investigate incidence and clustering of childhood cancers in 5 Italian regions Lazio LEONE MICHELA Clinico‐ Population Sciences and assistenzial Epidemiology e Epidemiology of Cancer ‐ EPIC GR‐2013‐ 02356268 Autism and prosopagnosia: investigate the role of oxytocin and its polymorphisms to improve face processing, memory and emotional contagion. SANTA LUCIA Minio Paluello Ilaria Biomedica Developmental Brain Disorders ‐ DBD GR‐2013‐ 02356272 SAN DONATO Predicting post‐surgery complications in patients undergoing coronary artery bypass graft through the assessment of perioperative cardiovascular control indices Bari Vlasta Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Surgery, Anesthesiology, and Trauma ‐ SAT GR‐2013‐ 02356275 Crayfish plague: molecular epidemiology of Aphanomyces astaci infections in the Italian native crayfish species Austropotamobius pallipes and in non‐ native crayfish populations that may act as reservoirs of infections Caprioli Riccardo Biomedica Veterinary Animal Health ‐ ANHE GR‐2013‐ 02356276 SIGNALING TO INVADOPODIA: THE ROLE OF SNARE I. O. V. PROTEINS IN LEUKEMIA DISSEMINATION Larghi Paola Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB GR‐2013‐ 02356278 Role of macrophages in the obesity‐associated colorectal cancer (CRC): searching for new therapeutic targets. I. O. V. Mazzon Cristina Biomedica Immunology Innate Immunity And Inflammation ‐ III GR‐2013‐ 02356281 Tackling maladaptive cortical oscillations: combining thalamocortical dysrhythmia, machine learning and neurofeedback to exert pain control and reduction. SANTA LUCIA Valentini Elia Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02356285 Tele‐Home‐Medicine Rehabilitation (THoMR) approach MAGGIORE for cerebellar disorders, combining non invasive cerebellar stimulation, computer‐based platform training and telemonitoring. Ferrucci Roberta Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN IZSAM Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Musculoskeletal, Oral and Skin Sciences Brain Disorders and Clinical Neuroscience Classificazione 2° liv. Arthritis, Connective Tissue and Skin ‐ ACTS Pagina 46 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02356287 Cost‐effectiveness of lung cancer primary and secondary prevention Toscana Carreras Giulia Biomedica Healthcare Delivery and Methodologies Biomedical Computing and Health Informatics ‐ BCHI GR‐2013‐ 02356288 Metabolic regulation of prostate cancer malignant phenotype Campania Terracciano Daniela Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME GR‐2013‐ 02356289 Chemoprevention as a strategy to hamper cancer stem cell phenotype in inflammation‐driven colon and breast tumors Emilia‐Romagna Penzo Marianna Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME GR‐2013‐ 02356293 Evaluation of the mechanisms sustaining the capability of SAN RAFFAELE MILANO endogenous neural stem cells to protect from ischemic stroke by restraining the pro‐inflammatory effects of danger signals. Butti Erica Biomedica Brain Disorders and Clinical Neuroscience Acute Neural Injury and Epilepsy ‐ ANIE GR‐2013‐ 02356296 Study of the ecology of antibiotic resistance spread through geo‐mapping and source attribution as key factor for an accurate risk assessment and management of Italian water bodies IZSVE Lettini Antonia Anna Biomedica Infectious Diseases and Microbiology Drug Discovery and Mechanisms of Antimicrobial Resistance ‐ DDR GR‐2013‐ 02356302 ''ETHICLAB'': A NEW BIOBANK TO PROMOTE LABORATORY ANIMAL TISSUE SHARING Istituto Superiore di Sanita' Sette Antonio Biomedica Veterinary Animal welfare ‐ ANWE GR‐2013‐ 02356305 A new promising treatment to selectively modulate the inflammatory response of microglia/macrophages in spinal cord injury MARIO NEGRI Rossi Filippo Biomedica Brain Disorders and Clinical Neuroscience Acute Neural Injury and Epilepsy ‐ ANIE GR‐2013‐ 02356306 Synaptic and non‐synaptic plasticity in cerebellar neurons in response to inflammation SANTA LUCIA Grasselli Giorgio Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT GR‐2013‐ 02356307 A CONTROLLED DELIVERY SYSTEM FOR HUMAN ENDOTHELIAL PROGENITOR CELL CONDITIONED MEDIUM AS A NEW POSSIBLE ALTERNATIVE TO CELL THERAPY IN TISSUE REGENERATION Toscana Felice Francesca Biomedica Vascular and Hematology Vascular Cell and Molecular Biology ‐ VCMB Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 47 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02356309 The extracellular matrix protein EMILIN2 as a regulator of the neutrophil response in the tumor inflammatory microenvironment during colon cancer development. C.R.O. AVIANO Andreuzzi Eva Biomedica GR‐2013‐ 02356311 Non‐invasive evaluation of portal hypertension in patients with liver cirrhosis by using a computational model Sicilia D'AMICO MARIO Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Hepatobiliary Pathophysiology ‐ HBPP GR‐2013‐ 02356314 Role of HLA‐G polymorphism in pediatric Multiple Sclerosis BURLO GAROFALO Celsi Fulvio Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT GR‐2013‐ 02356319 Interconnected networks of promoters: a new tool for prioritizing disease genes Toscana Di Patti Francesca Biomedica Genes, Genomes and Genetics Genomics, Computational Biology and Technology ‐ GCAT GR‐2013‐ 02356326 Role of TGFß signaling in the onset of Alzheimer¿s Disease: novel insight from Emilin proteins NEUROMED D'Andrea Ivana Biomedica Biobehavioral and Behavioral Processes Adult Psychopathology and Disorders of Aging ‐ APDA GR‐2013‐ 02356328 Next generation sequencing to speed up diagnosis and to MARIO NEGRI identify novel causes of atypical hemolytic uremic syndrome Mele Caterina Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD GR‐2013‐ 02356339 SERPINB3 AND DEREGULATION OF MYC ONCOGENE Veneto IN LIVER CARCINOGENESIS Turato Cristian Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC GR‐2013‐ 02356344 Development of a miRNA 103‐based diagnostic kit for cerebral ischemia. PIGNATARO GIUSEPPE Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN GR‐2013‐ 02356346 MICIA‐ Microbiome Identity Card for Imported Animals. IZSAM A Pilot study for the Microbiome Surveillance Associated with Exotic Animal Trade Lorusso Alessio Biomedica Veterinary Animal Health ‐ ANHE SDN Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Oncology 1 ‐ Basic Translational Classificazione 2° liv. Tumor Microenvironment ‐ TME Pagina 48 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02356358 Alternative in vitro models for assessing non‐essential trace elements (NOTEs) developmental toxicity: transcriptomic and metabolomic approach in farm animal cell lines and embryos, and translational research for human developmental toxicology. IZSPB Rutigliano Lucia Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular, Molecular and Integrative Reproduction ‐ CMIR GR‐2013‐ 02356359 Brain AKTion: neurobiology of AKT‐1 and AKT‐2 and its role in the pathophysiology and treatment of schizophrenia and bipolar disorder Toscana Palumbo Sara Biomedica Brain Disorders and Clinical Neuroscience Pathophysiological Basis of Mental Disorders and Addictions ‐ PMDA GR‐2013‐ 02356362 Cardiac remodelling in the Dravet Syndrome: genotype‐ phenotype correlations from mouse models to patient‐ derived cardiac myocytes CARLO BESTA Terragni Benedetta Biomedica Cardiovascular and Respiratory Sciences Electrical Signaling, Ion Transport, and Arrhythmias ‐ ESTA GR‐2013‐ 02356370 Study of neuroprotective effects of dexpramipexole in models of cerebral ischemia Toscana Muzzi Mirko Biomedica Brain Disorders and Clinical Neuroscience Brain Injury and Neurovascular Pathologies ‐ BINP GR‐2013‐ 02356373 A new multidisciplinary approach for assessing pain and distress in mice and rats following invasive surgery IZSVE Di Martino Guido Biomedica Veterinary Animal welfare ‐ ANWE GR‐2013‐ 02356375 Molecular mechanisms of immunomodulant effect of mesenchymal stromal cells (MSCs) on survival and proliferation of tumor cells SAN MATTEO Mantelli Melissa Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME GR‐2013‐ 02356377 Dissecting the human immune response to Istituto Superiore di Sanita' Mariotti Mycobacterium tuberculosis heparin‐binding hemagglutinin (HBHA) for a more accurate diagnosis and prevention of tuberculosis Sabrina Biomedica Infectious Diseases and Microbiology Host Interactions with Bacterial Pathogens ‐ HIBP GR‐2013‐ 02356381 EFFECT OF GLUCO AND LIPOTOXICITY ON GLP‐1 SECRETION AND L CELL FUNCTION Sicilia Urbano Francesca Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Molecular and Cellular Endocrinology ‐ MCE GR‐2013‐ 02356386 ANTI‐INFLAMMATORY AND NEUROPROTECTIVE ACTION OF IBUDILAST IN HUNTINGTON DISEASE SANTA LUCIA Paldino Emanuela Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 49 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02356388 The hypoxic microenvironment reprograms macrophage and dendritic cell functions in neuroblastoma: mechanisms of tumor progression GASLINI Raggi Federica Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME GR‐2013‐ 02356389 High throughput profile of microRNAs and proteomic analysis of hepatocellular carcinomas and non Hodgkin's lymphomas induced by Hepatitis C Virus chronic infection Toscana Gragnani Laura Biomedica Oncology 1 ‐ Basic Translational Cancer Etiology ‐ CE GR‐2013‐ 02356392 Investigating insertional mutagenesis as a new mechanism of HIV‐1 persistence in infected host SAN RAFFAELE MILANO Cesana Daniela Biomedica AIDS and Related Research AIDS Molecular and Cellular Biology ‐ AMCB GR‐2013‐ 02356399 Development of a human multifunctional anti‐ CEACAM1/IL‐2 immunoprotein in order to direct and strongly fire up the immune system's response against melanoma Istituto Superiore di Sanita' Ascione Alessandro Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII GR‐2013‐ 02356401 Targeting molecular mechanisms responsible for adaptation of cancer cells to metabolic stress as a novel approach in BRAF‐driven human malignancies CROB Sisinni Lorenza Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB GR‐2013‐ 02356416 Veneto Insulin resistance: insights from network genomics and molecular genetics into the metabolic and cardiovascular phenotype. A study in healthy individuals, in patients with newly diagnosed type 2 diabetes and in patients undergoing bariatric surgery. Dauriz Marco Clinico‐ Genes, Genomes and assistenzial Genetics e Genomics, Computational Biology and Technology ‐ GCAT GR‐2013‐ 02356434 Improving of safety and efficacy of antisense oligonucleotides using biocompatible and biodegradable nanoparticles as delivery system for exon‐skipping mediated therapies for neuromuscular disorders. OSPEDALE BAMBINO GESU' Passarelli Chiara Biomedica Bioengineering Sciences and Technologies Gene and Drug Delivery Systems ‐ GDD GR‐2013‐ 02356438 MicroRNAs: emerging players in modulating penetrance from ADOA to ADOA+. S.CAMILLO Grespi francesca Biomedica Cell Biology Cellular Signaling and Regulatory Systems ‐ CSRS Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 50 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02356443 An integrated microRNA profiling and Surface Enhanced C.R.O. AVIANO Raman Spectroscopy analysis of urine samples to predict prostate cancer prognosis. Cervo Silvia Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02356445 Molecular pathways in papillomavirus infections in large and small ruminants Russo Valeria Biomedica Infectious Diseases and Microbiology Infectious Diseases and Microbiology Fellowship ‐ F13 GR‐2013‐ 02356446 EFFECT OF A BCI‐CONTROLLED HUMANOID ROBOT Sicilia ON INDEPENDENCE AND QUALITY OF LIFE IN ALS PATIENTS Spataro Rossella Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02356455 Novel Approaches to Identify, Track and Specifically Target Acute Myeloid Leukemia Founder Mutations Vago Luca Aldo Edoardo Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC GR‐2013‐ 02356456 Veneto Muscle stem cells and extracellular matrix in obesity related sarcopenia: new insights for innovative diagnostic and terapeutic approaches Franzin Chiara Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO GR‐2013‐ 02356461 Potassium channels as new therapeutic target for brain tumors. Catalano Myriam Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT GR‐2013‐ 02356475 Toscana Longitudinal 36‐months prospective study aimed at exploring novel biomarkers and radiation‐free techniques useful to the early diagnosis, to the assessment of long‐ term outcome and to the early evaluation of response to therapy of Behçet¿s disease Talarico Rosaria Clinico‐ Immunology assistenzial e Hypersensitivity, Autoimmune, and Immune GR‐2013‐ 02356476 On‐farm welfare index evaluation for the Italian heavy pig ROTA NODARI SARA Biomedica Veterinary Animal welfare ‐ ANWE GR‐2013‐ 02356477 GASLINI Expression and function of nucleotide‐metabolizing ectoenzymes in the context of multiple myeloma niche in the bone marrow Morandi Fabio Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME IZSSA SAN RAFFAELE MILANO NEUROMED IZSLER Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 51 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02356484 Feasibility of using Brain‐Computer Interface for rehabilitation of spatial neglect S.CAMILLO Tonin Luca Clinico‐ Emerging Technologies and Neurotechnology ‐ assistenzial Training in Neurosciences NT e GR‐2013‐ 02356486 EFFECT OF NEURO‐AD, COMBINED rTMS STIMULATION AND COGNITIVE TRAINING, ON THE COGNITIVE FUNCTION OF PD WITH MILD COGNITIVE IMPAIRMENT S.CAMILLO Biundo Roberta Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02356488 Presence, bioaccumulation and toxicological risks from pharmaceuticals in marine bivalves IZSUM STRUBBIA SOFIA Biomedica Veterinary Food Safety ‐ FOSA GR‐2013‐ 02356497 miRNomics of neurodegenerative demyelination: development of progressive MS animal models CARLO BESTA Cordiglieri Chiara Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT GR‐2013‐ 02356499 Interactions between genetics and brain function in the amyotrophic lateral sclerosis (ALS)‐ frontotemporal dementia (FTD) continuum: a Whole Genome‐ Neuroimaging Association Study to identify novel biomarkers of neurodegeneration SDN Trojsi Francesca Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02356503 Assessing the role of Androgen Receptor (AR) in the prognosis and treatment of breast cancer Piemonte Castellano Isabella Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02356508 3D micro‐CT and FEA to optimize biomaterial performance in osteoporosis therapy Istituto Superiore di Sanita' Pecci Raffaella Biomedica Bioengineering Sciences and Technologies Biomaterials and Biointerfaces ‐ BMBI GR‐2013‐ 02356510 ReAD: Rehabilitation, Art & Dyslexia SANTA LUCIA Galli Giulia Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Developmental Brain Disorders ‐ DBD GR‐2013‐ 02356519 Circulating microRNA as predictive biomarkers in prediabetic and diabetic complications Veneto CATTELAN ARIANNA Biomedica Cellular Aspects of Diabetes and Obesity ‐ CADO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Endocrinology, Metabolism, Nutrition and Reproductive Sciences Pagina 52 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02356521 HUMANITAS CXCR4 mutants in Warts, Hypogammaglobulinemia, Infections and Myelokathexis (WHIM) and Waldenstrom Macroglobulinemia (WM) pathogenesis: signalling properties and therapeutic opportunities Borroni Elena Monica Biomedica Immunology Innate Immunity And Inflammation ‐ III GR‐2013‐ 02356522 Natural killer cells and macrophages cross‐talk in the pathogenesis of HIV‐1 infection HUMANITAS savino benedetta Biomedica Immunology Immunity and Host Defense ‐ IHD GR‐2013‐ 02356531 UNRAVELLING THE ROLE OF IMMUNE‐DERIVED OXYSTEROLS IN THE MAINTENANCE OF BREAST CANCER STEM CELL POPULATION IN VITRO AND IN VIVO SAN RAFFAELE MILANO Soncini Matias Cristobal Biomedica Immunology Transplantation, Tolerance and Tumor Immunology ‐ TTT GR‐2013‐ 02356535 The ADRIAS study: Arthropod‐borne Diseases in Residents, Immigrants and Animals living in Sicily. IZSSI Amodio Emanuele Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS GR‐2013‐ 02356537 Re‐programming of tumor metabolism by fasting as a strategy to enhance chemotherapy effectiveness GASLINI Bianchi Giovanna Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB GR‐2013‐ 02356541 EVALUATION OF THE PROGNOSTIC AND PREDICTIVE VALUE OF ION CHANNELS AND TRANSPORTERS PROFILE ("TRANSPORTOME") IN GASTRIC CANCER. Toscana LASTRAIOLI ELENA Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02356547 Functional dissection of inflammatory gene enhancers in macrophages I.E.O. OSTUNI RENATO Biomedica Genes, Genomes and Genetics Genomics, Computational Biology and Technology ‐ GCAT GR‐2013‐ 02356548 New strategies to control veterinary drug residues in food IZSUM Saluti Giorgio Biomedica Veterinary Food Safety ‐ FOSA GR‐2013‐ 02356549 Role of estrogens and their receptors in aldosterone synthesis in humans. Caroccia Brasilina Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Molecular and Cellular Endocrinology ‐ MCE Veneto Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 53 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA GR‐2013‐ 02356550 SRB1/ABCA1 cross‐talk as a possible new player in Rett syndrome pathogenesis GR‐2013‐ 02356553 Animal‐human concordance for breast cancer in national IZSME interest sites: a matter of food safety, short chain and living area. GR‐2013‐ 02356558 Set up of a new class of anti‐tumour compounds based on Istituto Superiore di Sanita' IESSI the fusion of proton pump inhibitors with scaffold molecules including carbonic anhydrase inhibitors or standard chemotherapeutics Elisabetta Biomedica GR‐2013‐ 02356563 Validation of an autoantibodies based test in the diagnosis of the breast cancer MAGGIORE Despini GR‐2013‐ 02356565 Facing the epidemics of Celiac Disease since the early days: a large scale study of epigenetic and environmental risk factors. Campania GR‐2013‐ 02356568 Immunoregulatory role of innate immunity cells in the tumor microenvironment IRCCS AOU San Martino‐ IST (Genova) GR‐2013‐ 02356569 GR‐2013‐ 02356573 P.I. Classificazione 2° liv. Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD Veterinary Food Safety ‐ FOSA Oncology 2 ‐ Translational Clinical Drug Discovery and Molecular Pharmacology ‐ DMP Luca Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS GALATOLA MARTINA Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD Vacca Paola Biomedica Immunology Transplantation, Tolerance and Tumor Immunology ‐ TTT STABILITY AND INSTABILITY OF ATHEROSCLEROTIC Puglia PLAQUES: THE BLOODSTREAM DISCLOSURE OF THE PROBLEM Scicchitano Pietro Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS Piemonte Influence of Different Perfusion and Aortic Clamping Techniques in Minimally Invasive Mitral Valve Surgery: A Randomized Clinical Trial Ricci Davide Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR Toscana Biomedica Classificazione 1 Liv. STICOZZI CLAUDIA Serpe Francesco Paolo Biomedica Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 54 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA GR‐2013‐ 02356574 NEW APPROACHES FOR LEGIONELLA AND BIOFILM Istituto Superiore di Sanita' Fontana CONTROL IN DENTAL UNIT WATERLINE: USE OF TERPINEN‐4‐OL ALONE OR IN CONBINATION WITH CONVENTIONAL WATER SYSTEM DISINFECTION PROCEDURES Stefano GR‐2013‐ 02356576 Unveiling the potential of Circulating Melanoma Cells (CMCs): round trip from bench to bedside I. O. V. SCAINI MARIA CHIARA Clinico‐ GR‐2013‐ 02356584 Primary systemic vasculitides, AtheroSclerosis And HDL dysfunCTION (VAS ACTION) Emilia‐Romagna PALMISANO GR‐2013‐ 02356592 Role of muscle interstitial fibroadipogenic progenitors in the regulation of myofiber response to acute and pathological denervation SANTA LUCIA GR‐2013‐ 02356593 From monogenic to multifactorial auto‐inflammatory disease: pathogenetic study, epigenetic changes and therapeutic targets. BURLO GAROFALO GR‐2013‐ 02356596 Development of a rapid drug susceptibility test for Mycobacterium tuberculosis using electronparamagnetic resonance GR‐2013‐ 02356610 GR‐2013‐ 02356611 P.I. Biomedica Classificazione 1 Liv. Classificazione 2° liv. Risk, Prevention and Health Behavior Risk, Prevention and Intervention for Addictions ‐ RPIA Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS ALESSANDRA Biomedica Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR Madaro Luca Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN Marcuzzi Annalisa Biomedica Immunology Innate Immunity And Inflammation ‐ III Istituto Superiore di Sanita' Piccaro Giovanni Biomedica Infectious Diseases and Microbiology Drug Discovery and Mechanisms of Antimicrobial Resistance ‐ DDR Identification of genotype‐related molecular targets in the vitamin D pathway for personalized pharmacological treatments of the spinal disc diseases GALEAZZI Colombini Alessandra Biomedica Cell Biology Cellular Signaling and Regulatory Systems ‐ CSRS A potential role of ELAV RNA‐binding proteins in the pathogenesis of amyotrophic lateral sclerosis (ALS) AUXOLOGICO Colombrita Claudia Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Cardiovascular and Respiratory Sciences Pagina 55 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02356612 Neuroinflammation and Mevalonic Aciduria: mitochondrial damage and inflammasome involvement. BURLO GAROFALO Tricarico Paola Maura Biomedica GR‐2013‐ 02356617 Circulating Tumor Cells in prostate cancer patients: identification of new response predictive markers to androgen depletion therapy. I.E.O. Musi Gennaro Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS GR‐2013‐ 02356621 Immune response regulation by long non‐coding RNA and micro‐RNA in rheumatoid arthritis and juvenile idiopathic arthritis Toscana santarlasci veronica Biomedica Immunology Cellular and Molecular Immunology A ‐ CMIA GR‐2013‐ 02356622 Circulating microRNAs as novel biomarkers of disease and response to therapy in pediatric medulloblastoma OSPEDALE BAMBINO GESU' Mastronuzzi Angela Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP GR‐2013‐ 02356623 Role of tumor‐derived oxysterols in monocytic cell fate within the tumor microenvironment. SAN RAFFAELE MILANO Raccosta Laura Biomedica Immunology Transplantation, Tolerance and Tumor Immunology ‐ TTT GR‐2013‐ 02356630 Resistance to HIV‐1 protease inhibitors: genotypic and phenotypic evaluation of the impact of gp41 env mutations. Lombardia Franzetti Marco Biomedica AIDS and Related Research AIDS Molecular and Cellular Biology ‐ AMCB GR‐2013‐ 02356631 Towards a physiological cure of Diabetic Retinopathy: prevention/regression by treatment with Chromogranin A fragment Vasostatin‐1 SAN RAFFAELE MILANO Maestroni Silvia Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Diabetes, Metabolism, Nutrition and Obesity Small Business SEP (EMNR E10 B) GR‐2013‐ 02356634 Functional connectivity changes after Traumatic Brain Injury: MEG and fMRI studies SANTA LUCIA Betti Viviana Biomedica Brain Disorders and Clinical Neuroscience Brain Injury and Neurovascular Pathologies ‐ BINP GR‐2013‐ 02356647 A novel, peptide‐based, optical diagnostic tool to identify Toscana and quantify microrganisms in biofilm‐associated infections Di Luca Mariagrazia Biomedica Bioengineering Sciences and Technologies Microscopic Imaging and Spectroscopy ‐ MIS* Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Molecular, Cellular, and Developmental Neuroscience Neural Oxidative Metabolism and Death ‐ NOMD Pagina 56 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02356648 Epigenetic modulation of the C9ORF72 promoter in patients affected by amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD) and ALS/FTLD and possible therapeutic implications Lombardia Mosca Lorena Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02356649 Effects of the antiparkinsonian drug Pramipexole on the development of compulsivity in rats: modulation of hippocampus‐ventral striatum loop by chronic stimulation of dopamine D2/D3 receptors. SANTA LUCIA schepisi chiara Biomedica Brain Disorders and Clinical Neuroscience Pathophysiological Basis of Mental Disorders and Addictions ‐ PMDA GR‐2013‐ 02356652 Iodothyronines and thyromimetics: potential applications Campania in homozygous familial hypercholesterolemia. Silvestri Elena Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Molecular and Cellular Endocrinology ‐ MCE GR‐2013‐ 02356664 Nutraceuticals: potential therapeutic value in parkinsonism NEUROMED Biagioni Francesca Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02356666 DISCO TRIP ‐ Disrupting Respiratory Complex I to Trigger Pseudonormoxia: an anticancer strategy Emilia‐Romagna Gasparre Giuseppe Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB GR‐2013‐ 02356667 Targeting microRNAs as novel anti‐tumor approach for KRAS mutant colorectal cancer REGINA ELENA Fiori Micol Eleonora Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB GR‐2013‐ 02356669 Identification of mechanisms involved in the pathogenesis of neoplastic clones in Large Granular Lymphocytes Disorders (LGL) Veneto Gattazzo Cristina Biomedica Immunology Cellular and Molecular Immunology B ‐ CMIB GR‐2013‐ 02356672 Circulating tumour cells as markers of tumour aggressiveness in metastatic colorectal cancer Istituto Scientifico Romagnolo Fabbri Francesco Biomedica Oncology 1 ‐ Basic Translational Tumor Progression and Metastasis ‐ TPM2 GR‐2013‐ 02356681 Longitudinal prospective study of neurodegenerative Langerhans cell histiocytosis (ND‐LCH): a multidisciplinary approach. Toscana Sieni Elena Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Clinical Neuroscience and Neurodegeneration ‐ CNN Pagina 57 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02356683 Development of a tridimensional in vitro canine breast cancer/Mesenchymal Stromal Cells (MSCs) co‐culture model to reduce the use of animals in oncological studies IZSSI Di Bella Santina Biomedica Veterinary Animal welfare ‐ ANWE GR‐2013‐ 02356686 Innate immune response in obesity: in vitro and in vivo studies of molecular mechanisms and therapeutic strategies in neurodegeneration Veneto Zusso Morena Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02356694 Piemonte Development of gut microbiota indicators in new strategies for early diagnosis and manage of children type 1 dibetes and irritable bowel syndrome. Traversi Deborah Biomedica Genes, Genomes and Genetics Prokaryotic Cell and Molecular Biology ‐ PCMB GR‐2013‐ 02356701 Plant extracts as a source of anti‐inflammatory agents to threat Benign Prostatic Hyperplasia Daniele Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Molecular and Cellular Endocrinology ‐ MCE GR‐2013‐ 02356703 Impact of lipid metabolism alterations on influenza virus SAN RAFFAELE PISANA replication and host cell response SGARBANTI ROSSELLA Biomedica Infectious Diseases and Microbiology Virology A and B Study Sections ‐ VIRA and VIRB GR‐2013‐ 02356705 Transcranial MRI‐guided focused ultrasound (tcMRgFUS) to treat neurological disorders: preliminary Sicilia Gagliardo Cesare Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Bioengineering, Technology, and Surgical Sciences ‐ BTSS GR‐2013‐ 02356711 Optimization of extracorporeal carbon dioxide removal through blood acidification: development of new technologies Lombardia Zanella Alberto Biomedica Bioengineering Sciences and Technologies Instrumentation and Systems Development ‐ ISD GR‐2013‐ 02356714 Molecular Nanodecoders for the Quantitative, Multiplexed, Layer‐by‐Layer Imaging of Disease‐ Associated Markers Friuli‐Venezia Giulia Castronovo Matteo Biomedica Bioengineering Sciences and Technologies Nanotechnology ‐ NANO GR‐2013‐ 02356716 In vitro model for cancer stem cell niche Istituto Superiore di Sanita' Bozzuto Giuseppina Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB Istituto Superiore di Sanita' Marcoccia Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 58 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02356717 Prognostic and predictive significance of liquid biopsy (Circulating Tumor Cells and cell‐free nucleic acids) in neuroendocrine neoplasms Toscana Antonuzzo Lorenzo Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS GR‐2013‐ 02356726 A recombinant antibody to CCR5 as immunotherapy against HIV transmission SAN RAFFAELE MILANO VENUTI ASSUNTA Biomedica AIDS and Related Research AIDS Discovery and Development of Therapeutics ‐ ADDT GR‐2013‐ 02356742 A novel liver‐on‐chip approach for studying NAFLD: REGINA ELENA analysis of the miRNome associated to the status of p53 in a 3D in vitro model of human steatosis as new diagnostic and prognostic tool Gori Manuele Biomedica Digestive, Kidney and Urological Systems Hepatobiliary Pathophysiology ‐ HBPP GR‐2013‐ 02356743 Opioids in chronic non cancer pain patients: clinical aspects in long‐term treatment CONVERSA GIANLUCA Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health and Health Related Behavior of Individuals and Populations Fellowship ‐ F16 GR‐2013‐ 02356745 Proteomic and metabolomic characterization of the renal Puglia and cardiovascular impairment in HIV patients: new tools to discriminate the impact of the virus, the comorbidities and the antiretroviral drugs toxicities Papale Massimo Biomedica AIDS and Related Research AIDS Clinical Studies and Epidemiology ‐ ACE GR‐2013‐ 02356747 BAP1‐dependent Malignant Mesothelioma: mechanisms and early detection Emilia‐Romagna GIORGI CARLOTTA Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP GR‐2013‐ 02356749 microRNAs as Functional Markers for Treatment Refractory Leukaemia SAN RAFFAELE MILANO Gentner Bernhard Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP GR‐2013‐ 02356752 Control of TGFß pro‐metastatic activitiy by targeting the pro‐angiogenic Growth and Differentiation Factor‐5 (GDF5) in the progression of breast cancer. Toscana Laurenzana anna Biomedica Oncology 1 ‐ Basic Translational Tumor Progression and Metastasis ‐ TPM2 GR‐2013‐ 02356753 Curcumins and RNA metabolism: investigating the involvement of coding and non‐coding RNA in Alzheimer's disease MONDINO Gagliardi Stella Biomedica Genes, Genomes and Genetics Molecular Genetics ‐ MGA MAUGERI Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 59 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02356760 inflammatory Cerebral amyloid Angiopathy and Alzheimer's disease ßiomarkers CARLO BESTA Piazza Fabrizio Biomedica GR‐2013‐ 02356771 Challenging the role of chemotherapy in HER2 positive early breast cancer: PI3KCA pathways alteration and response to neoadjuvant pertuzumab‐trastuzumab plus letrozole or paclitaxel in Hormone Receptor positive‐ HER2 positive breast cancer patients. I. O. V. Guarneri Valentina Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC GR‐2013‐ 02356776 Integrated analysis of effector/regulatory immune‐ response and microbiota in Crohn's Disease (CD) patients and in healthy relatives with NOD2 Istituto Superiore di Sanita' Butera Alessia Biomedica Immunity and Host Defense ‐ IHD GR‐2013‐ 02356779 Relatioship between endothelial progenitor cells, APOE genotype, and cerebrovascular perfusion in Alzheimer disease Toscana Baldacci Filippo Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Cell Death in Neurodegeneration ‐ CDIN GR‐2013‐ 02356784 EVALUATION OF THE ABILITY OF MESENCHYMAL STROMAL CELLS (MSCs) AND HEMATOPOIETIC STEM CELLS (HSCs) TO RESTORE RENAL FUNCTION IN A MURINE MODEL OF ACUTE EXPERIMENTAL INDUCED RENO‐VASCULAR DISEASE IZSSI Altomare Roberta Biomedica Digestive, Kidney and Urological Systems Renal and Urological Sciences Small Business Activities ‐ SERU GR‐2013‐ 02356786 Cell‐on‐chip model for new immunotherapy approach to Lazio overcome the resistance to triple negative breast cancer treatments: the role of interaction between cancer stem cell and macrophage polarization Pantano Francesco Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME GR‐2013‐ 02356788 Dissecting the role of FUS/CHOP and EWSR1/CHOP partnership in myxoid liposarcoma development. Brenca Monica Clinico‐ Oncology 1 ‐ Basic assistenzial Translational e GR‐2013‐ 02356793 Veneto Brain PET/MRI using simultaneously the absolute quantification of 18F‐FDG, fMRI and brain structurall evaluation in pre and post‐surgical brain tumors: is it a one stop shop to predict outcome and drive rehabilitation ? Cecchin Diego Clinico‐ Emerging Technologies and Neurotechnology ‐ assistenzial Training in Neurosciences NT e C.R.O. AVIANO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Brain Disorders and Clinical Neuroscience Immunology Clinical Neuroscience and Neurodegeneration ‐ CNN Cancer Molecular Pathobiology ‐ CAMP Pagina 60 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02356799 Circulating nucleic acids in colorectal cancer: new non‐ ISTITUTO TUMORI invasive tools to improve surveillance in high risk patients MILANO GR‐2013‐ 02356817 Investigating the role of mitochondria‐ER interaction in CMT: new insights in the biology of peripheral neuropathy GR‐2013‐ 02356820 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. DELCONTE GABRIELE Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS S.CAMILLO Giacomello Marta Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN Clinical relevance of STAT3 activation in the setting of chemotherapy resistance: from biological characterization to the development of new strategies to overcome the resistant phenotype in solid tumors Campania Pisanti Simona Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT GR‐2013‐ 02356821 Mitochondrial DNA dynamics: Implications in neurodegenerative diseases S.CAMILLO Soriano Garcia Maria Eugenia Cuerva Biomedica Cell Biology Nuclear and Cytoplasmic Structure/Function and Dynamics ‐ NCSD GR‐2013‐ 02356830 Whole‐genome sequencing for epidemiological identification of clinical and environmental isolates of Legionella spp in outbreak investigations. Work insurance implications. INAIL Celenza Giuseppe Biomedica Population Sciences and Epidemiology Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions ‐ IRAP GR‐2013‐ 02356831 Isolation and characterization of thyroid cancer stem cells to identify novel molecular targets in the aggressive thyroid tumors unresponsive to the current treatment Lazio Cosimo Durante Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02356832 CMR evaluation of myocardial inflammation persistence after acute myocarditis: prognostic relevance SAN RAFFAELE MILANO Esposito Antonio Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS GR‐2013‐ 02356835 MAGGIORE Definition of standard age‐ and gender‐related ultrasound reference values for joint structures in healthy children. filocamo giovanni Clinico‐ Musculoskeletal, Oral and assistenzial Skin Sciences e Arthritis, Connective Tissue and Skin ‐ ACTS Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 61 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO GR‐2013‐ 02356841 Biological and clinical markers in Major Depressive Disorder GR‐2013‐ 02356846 DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Calati Raffaella Biomedica Brain Disorders and Clinical Neuroscience Pathophysiological Basis of Mental Disorders and Addictions ‐ PMDA MicroRNA Regulation of Cardiac Stem Cell Regeneration Calabria Potential in Diabetes Mellitus Vicinanza Carla Biomedica Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF GR‐2013‐ 02356875 Understanding mechanisms of Myotonic Dystrophy muscle atrophy: new therapeutic approaches Lazio TERRACCIAN CHIARA O Biomedica Musculoskeletal, Oral and Skin Sciences Skeletal Muscle Biology and Exercise Physiology ‐ SMEP GR‐2013‐ 02356876 The NGF‐TrkA control of APP phosphorylation and processing in retinal ganglion cells (RGC) affected by Alzheimer¿s Disease‐like neurodegeneration and glaucoma. BIETTI Triaca Viviana Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND GR‐2013‐ 02356886 Adipose Derived Stem Cells (ADSCs): Differentiation and Sicilia Engineering for Peripheral Nerve Defect Reconstruction. zabbia giovanni Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences ‐ BTSS GR‐2013‐ 02356887 Development and validation of a mathematical model for Piemonte esteem of central blood pressure in normal subjects and in patients with proximal aorta dilatation MILAN ALBERTO Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Medical Imaging ‐ MEDI GR‐2013‐ 02356892 TMS application in the treatment of Eating Disorders Piemonte Folegatti Alessia Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Neural Basis of Psychopathology, Addictions and Sleep Disorders ‐ NPAS GR‐2013‐ 02356900 Prothymosin alpha as a new therapeutic strategy for improving post‐ischemic left ventricular remodeling and dysfunction via G‐protein coupled receptor kinase 2 (GRK2) down‐regulation in the failing heart. MAUGERI CANNAVO ALESSANDRO Biomedica Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF FATEBENEFRATELLI Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Cardiovascular and Respiratory Sciences Pagina 62 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02356901 Developing innovative mHealth integrated solutions for AUXOLOGICO empowering type 2 diabetic and obese patients in remote self‐monitoring and chronic care management using mobile devices, apps, social media and web‐based technologies: the DIABESITY 3.0 feasibility, Castelnuovo Gianluca Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO GR‐2013‐ 02356902 Study of non coding‐RNAs as new biomarkers in cancer. Toscana Acunzo Mario Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02356903 Use of genetic‐driven dysbindin‐1 (DTNBP1) variations for personalized treatments in First Episode of Psychosis MEDEA Mereu Maddalena Biomedica Brain Disorders and Clinical Neuroscience Neural Basis of Psychopathology, Addictions and Sleep Disorders ‐ NPAS GR‐2013‐ 02356904 Novel therapeutic options for hypertrophic cardiomyopathy: a quest for a personalized, genotype‐ driven treatment Toscana Coppini Raffaele Biomedica Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF GR‐2013‐ 02356906 Connectivity‐based neural markers to describe and quantify cortical plasticity induced by motor rehabilitation SANTA LUCIA Astolfi Laura Biomedica Brain Disorders and Clinical Neuroscience Acute Neural Injury and Epilepsy ‐ ANIE GR‐2013‐ 02356907 The potential of stem cells on nerve regeneration: unraveling the effect of human mesenchymal stromal cells in experimental hypoxic ischemic brain injury. BURLO GAROFALO Valencic Erica Biomedica Molecular, Cellular, and Developmental Neuroscience Neurodifferentiation, Plasticity, and Regeneration ‐ NDPR GR‐2013‐ 02356908 Early brain imaging and neuromonitoring combined with MAGGIORE clinical assessment to predict long‐term behavioural problems in preterm infants. De Carli Agnese Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Developmental Brain Disorders ‐ DBD GR‐2013‐ 02356923 The genetic contribution of the gamma‐interferon‐ inducible lysosomal thiol‐reductase IFI30 in the immune and central nervous system in the context of multiple sclerosis: could it be a useful marker for personalizing treatment? Ottoboni Linda Biomedica Genetics of Health and Disease ‐ GHD SAN RAFFAELE MILANO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Genes, Genomes and Genetics Classificazione 2° liv. Pagina 63 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02356926 Resistance to temozolomide in glioblastoma multiforme: role of mitotic slippage and USP1‐regulated apoptosis Emilia‐Romagna Feletti Alberto Biomedica GR‐2013‐ 02356929 Therapeutic target of vitamin D to prevent cardiovascular disease in CKD patients. SAN RAFFAELE MILANO Arcidiacono Teresa Clinico‐ Vascular and Hematology assistenzial e Atherosclerosis and Inflammation of the Cardiovascular System ‐ AICS GR‐2013‐ 02356947 From tissues to serum in canine mammary cancer: the role of miRNAs in an integrated concept of malignant tumor progression IZSUM Pavone Silvia Biomedica Veterinary Animal Health ‐ ANHE GR‐2013‐ 02356955 Increase of tumor drug penetration by tissue‐ internalizing nanocarriers: a novel personalized strategy for Neuroblastoma therapy GASLINI Brignole Chiara Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT GR‐2013‐ 02356961 INNOVATIVE FORCEPS FOR BETTER MANAGEMENT OF PATIENTS AND REDUCTION OF COSTS IN LAPAROSCOPIC SURGERY Calabria Rizzuto Antonia Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Bioengineering, Technology, and Surgical Sciences ‐ BTSS GR‐2013‐ 02356964 Geomedicine of type 2 diabetes: genetic, environmental and social dterminants in the Basilicata region. Basilicata Ceccarelli Elena Biomedica Risk, Prevention and Health Behavior SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan ‐ TPM1 GR‐2013‐ 02356967 ENDOgenous ENDOchondral bone regeneration driven by inspired biomaterials (ENDO2) GALEAZZI Scotti Celeste Biomedica Musculoskeletal, Oral and Skin Sciences Musculoskeletal Tissue Engineering ‐ MTE GR‐2013‐ 02356972 REGULATION OF SPLICING FACTORS DURING AUTOPHAGY AND THEIR ROLE IN NEURODEGENERATION. SANTA LUCIA valacca cristina Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND GR‐2013‐ 02356975 Intensive nutritional counseling in cancer patients undergoing radiotherapy: a randomized controlled trial. SAN MATTEO CACCIALANZ RICCARDO A Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Oncology 2 ‐ Translational Clinical Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Basic Mechanisms of Cancer Therapeutics ‐ BMCT Clinical Oncology ‐ CONC Pagina 64 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA GR‐2013‐ 02356976 Functional and structural connectivity rearrangement after epilepsy surgery S.CAMILLO Storti Silvia Francesca Clinico‐ GR‐2013‐ 02356978 Targeting KRAS mutations in NSCLC through LKB1 co‐ vulnerability ISTITUTO TUMORI MILANO Platania GR‐2013‐ 02356987 Effectiveness of post‐prandial exercise and training interventions in improving glycemic control and reducing cardiovascular‐related complications in type 2 diabetes patients Marche GR‐2013‐ 02356993 Whole‐genome sequencing approach for gene discovering in Common Variable Immunodeficiency (CVID) GR‐2013‐ 02356994 P.I. Classificazione 1 Liv. Classificazione 2° liv. Brain Disorders and assistenzial Clinical Neuroscience e Acute Neural Injury and Epilepsy ‐ ANIE Marco Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC Lucertini Francesco Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO Emilia‐Romagna Di Pierro Valentina Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD Anti‐tumor effects of conjugates between Tumor Associated Antigens and a novel TLR7‐ligand (modified adenine) in humanized models of lung cancer and melanoma Toscana Pratesi Sara Biomedica Immunology Transplantation, Tolerance and Tumor Immunology ‐ TTT GR‐2013‐ 02357003 MicroRNAs as biomarkers for acute graft‐versus‐host disease in pediatric patients given allogeneic hematopoietic stem cell transplantation OSPEDALE BAMBINO GESU' Bertaina Alice Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02357021 Role of renal progenitors in renal cell carcinoma formation Toscana Peired Anna Biomedica Digestive, Kidney and Urological Systems Cellular and Molecular Biology of the Kidney ‐ CMBK GR‐2013‐ 02357025 Diagnostic strategy proposal to identify and treat Normal Lazio Pressure Hydrocephalus patients among senile dementia population. Rigante Luigi Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02357044 Neuroprotective effects of a natural phytochemical extracted from Moringa oleifera in an experimental model of Parkinson's disease. Giacoppo Sabrina Biomedica Clinical Neuroscience and Neurodegeneration ‐ CNN NEUROLESI Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Brain Disorders and Clinical Neuroscience Pagina 65 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02357051 fABLE ‐ Favouring the Acquisition of functional Basic Locomotor primitives for Enabling walking in children with cerebral palsy SANTA LUCIA Iosa Marco Biomedica GR‐2013‐ 02357052 Web‐based Motherhood choice decision aid for women with Multiple Sclerosis (We‐MoMS): A proof‐of‐concept study CARLO BESTA Giordano Andrea Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroimmunology and Brain Tumors ‐ CNBT GR‐2013‐ 02357075 SDN Epigenetic remodeling of ncx3 gene by drugs inhibiting histone deacetylases (HDACs) class II A: a new strategy to reduce the neuronal damage in brain ischemia Formisano Luigi Biomedica Brain Disorders and Clinical Neuroscience Brain Injury and Neurovascular Pathologies ‐ BINP GR‐2013‐ 02357077 Effects of fibrate‐induced mitochondria biogenesis in a mouse model of progressive multiple sclerosis Toscana buonvicino daniela Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN GR‐2013‐ 02357078 Diagnostic and prognostic value of contrast‐enhanced cardiovascular magnetic resonance for noninvasive detection of cardiac involvement in systemic amyloidosis Toscana Barison Andrea Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF GR‐2013‐ 02357080 The role of HIPK2 in the diagnosis, therapy and clinical care of cerebellar ataxia SDN Anzilotti Serenella Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND GR‐2013‐ 02357081 Targeting SUMO1‐tau protein interaction in Alzheimer's disease and tauopathy SANTA LUCIA Nisticò Robert Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN GR‐2013‐ 02357092 Preclinical biomarkers of interictal psychosis in epilepsy: a combined EEG/fMRI study correlated with pupillary response. S.CAMILLO Anzellotti Francesca Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02357093 Role of interferon‐gamma in promoting graft‐versus‐host Veneto disease in allogeneic hematopoietic stem‐cell transplantation recipients Ugel stefano Biomedica Immunology Transplantation, Tolerance and Tumor Immunology ‐ TTT Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Brain Disorders and Clinical Neuroscience Classificazione 2° liv. Developmental Brain Disorders ‐ DBD Pagina 66 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02357103 Relation between endothelial progenitor cells and carotid Lombardia plaque vascularization in atherosclerosis and large‐vessel vasculitides. The role of plaque vascularization as marker and therapeutic target in humans and animal models. Ammirati Enrico Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Medical Imaging ‐ MEDI GR‐2013‐ 02357105 Improving social decision making in neurological patients with acquired sociopathy syndrome Panasiti Maria Serena Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02357115 Genome landscape of juvenile myelomonocytic leukemia: Veneto a comprehensive study to identify mechanisms related to high risk of relapse Bresolin Silvia Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC GR‐2013‐ 02357120 microRNA‐BASED APPROACHES FOR HEPATIC TUMOR PROPHYLAXIS AND THERAPY Emilia‐Romagna CALLEGARI ELISA Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC GR‐2013‐ 02357122 Exosomes as delivery platform for packing siRNAs to study the role of Proteoglycans in the pathogenesis of Alzheimer¿s Disease. NEUROLESI Scuruchi Michele Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02357124 Age‐related inflammation as a common causative pathway in altered glucose metabolism and sarcopenia: characterization of early biomarkers of disease and identification of potential therapeutic targets Lazio Conte Caterina Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO GR‐2013‐ 02357134 Toward an individualized use of mitotane treatment in patients affected by adrenocortical carcinoma: genetic profiling as tool to better manage patients outcome and their quality of life. Piemonte De Francia Silvia Biomedica Oncology 1 ‐ Basic Translational Cancer Genetics ‐ CG GR‐2013‐ 02357136 Emilia‐Romagna COMPOSITION OF GUT MICROBIOTA AND IMPACT ON IMMUNE SYSTEM RECOVERY AND ACUTE GRAFT VERSUS HOST DISEASE IN PEDIATRIC PATIENTS UNDERGOING HEMATOPOIETIC STEM CELL TRANSPLANTATION Masetti Riccardo Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII SANTA LUCIA Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 67 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02357137 Anti‐ischemic, anti‐arrhythmic and metabolic effect of Ranolazine in Hypertrophic Cardiomyopathy and in animal models of ventricular hypertrophy Toscana Todiere GR‐2013‐ 02357140 P‐glycoprotein mediates the interactions between antiretrovirals and lipids: impact on the effectiveness of HAART, lipids metabolism and atherosclerosis in HIV treated patients. SPALLANZANI Tempestilli GR‐2013‐ 02357141 Possible role of NF‐kB activation by microbiome as concause of neurodegeneration in Alzheimer's disease NEUROLESI GR‐2013‐ 02357144 Diet‐related metabolic diseases and brain function: identification of novel clinical biomarkers of cognitive decline GR‐2013‐ 02357156 Classificazione 1 Liv. Classificazione 2° liv. Giancarlo Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF Massimo Clinico‐ AIDS and Related Research assistenzial e AIDS Clinical Studies and Epidemiology ‐ ACE Marino Merlo Francesca Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN Lazio Sorice Gian Pio Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO Fast tuning of the immune response across the blood brain barrier by drug repurposing in a preclinical setting for translation into stroke therapy SANTA LUCIA Amantea Diana Biomedica Brain Disorders and Clinical Neuroscience Brain Injury and Neurovascular Pathologies ‐ BINP GR‐2013‐ 02357157 Efficacy of the treatment with Bifidobacterium Breve B632 and Bifidobacterium Breve BR03 on endocrine response to the oral glucose tolerance test in pediatric obesity: a double blind randomized controlled trial Piemonte Prodam Flavia Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO GR‐2013‐ 02357165 Telomere length, glycomics and genetics as new predictive biomarkers to improve outcome of breast cancer patients Emilia‐Romagna Napolioni Valerio Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS GR‐2013‐ 02357176 Small RNA‐seq: an innovative tool to explore the key role HUMANITAS of cardiac and immunoregulatory miRNAs in Fabry Disease. Viviani Anselmi Chiara Biomedica Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Cardiovascular and Respiratory Sciences Pagina 68 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02357191 Identification and characterization of early biomarkers for Alzheimer's disease using ex‐vivo monocytes NEUROLESI Ferlazzo Nadia Clinico‐ Molecular, Cellular, and assistenzial Developmental e Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND GR‐2013‐ 02357193 Understanding the language of Schwann stromal and Neuroblastoma cell cross‐talk under hypoxic and non‐ hypoxic conditions: an approach to improve the therapy of neuroblastoma. Veneto Aveic Sanja Biomedica Intercellular Interactions ‐ ICI GR‐2013‐ 02357194 Lazio Brain Function Monitoring to Evaluate Efficacy and Safety of Palliative‐Sedation‐in‐the‐ Last‐Days‐Therapy in Terminally Cancer Patients. Gian Paolo Spinelli Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Medical Imaging ‐ MEDI GR‐2013‐ 02357211 A MULTIMODAL APPROACH TO STUDY IRON ROLE IN HUNTINGTON'S DISEASE FROM CENTRAL TO PERIPHERAL DISTRICT Sanchez Castaneda Cristina Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02357217 Lazio Circulating microRNAs' expressions profile in gastric cancer patients as predictor of response to chemotherapy treatments Lorenzon Laura Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02357220 A neuroregenerative approach to Parkinson's disease based on the modulation of cerebral Rac and Cdc42 GTPases MARCO Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN GR‐2013‐ 02357224 Immune response against tumor by PUFA and Orlistat in DE BELLIS colorectal cancer Favoino Elvira Biomedica Risk, Prevention and Health Behavior Behavioral Medicine: Interventions and Outcomes ‐ BMIO GR‐2013‐ 02357229 Kv7 CHANNEL AS A NEW MITOCHONDRIAL K+ CHANNEL IN NEURONS AND CARDIAC CELLS: EXPRESSION, FUNCTIONAL CHARACTERIZATION, AND POSSIBLE PROTECTIVE ROLE AGAINST ISCHEMIA‐REPERFUSION INJURY. Miceli Francesco Biomedica Brain Disorders and Clinical Neuroscience Brain Injury and Neurovascular Pathologies ‐ BINP SANTA LUCIA Istituto Superiore di Sanita' MUSILLI SDN Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Cell Biology Pagina 69 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02357237 Boosting Cellular MRI for Cell Therapy Applications in Neuroimmunological Disorders GR‐2013‐ 02357239 AREA P.I. Classificazione 1 Liv. Mastropietro Alfonso Biomedica Heart failure screening network in Calabria. A method to Calabria reduce hospitalization and patient migration Santise Gianluca Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF GR‐2013‐ 02357242 PHAge‐based nanoBIOsensing detection of Brucella spp. ‐ PHA.BIO. BORRIELLO GIORGIA Biomedica Bioengineering Sciences and Technologies Instrumentation and Systems Development ‐ ISD GR‐2013‐ 02357246 Characterization of immune system in heart failure: from NEUROMED experimental models to humans. Carnevale Daniela Biomedica Cardiovascular and Respiratory Sciences Clinical and Integrative Cardiovascular Sciences ‐ CICS GR‐2013‐ 02357265 Investigation of routes of transmission for community acquired Clostridium difficile infection (CDI) and development of an aptamer‐based biosensor for rapid Clostridium difficile screening Romano Vincenza Biomedica Infectious Diseases and Microbiology Clinical Research and Field Studies of Infectious Diseases ‐ CRFS GR‐2013‐ 02357273 Type I IFN‐mediated induction of a chemoresistant niche REGINA ELENA of tumor cells: from animal models to humans SISTIGU ANTONELLA Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME GR‐2013‐ 02357274 Clinical, molecular and functional characterization of some syndromic congenital cerebellar disorders OSPEDALE BAMBINO GESU' BARRESI SABINA Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD GR‐2013‐ 02357277 Development, validation and Cloud‐based implementation of a Magnetic Resonance (MR) Biomarker of Prostate Cancer (PCa) Aggressiveness. Istituto Oncologico Candiolo Giannini Valentina Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Biomedical Imaging Technology ‐ BMIT GR‐2013‐ 02357281 Function of Natural Killer cells in type 2 diabetes mellitus MULTIMEDICA and a non‐autoimmune diabetes mellitus syndrome. Bruno Antonino Biomedica Vascular and Hematology Atherosclerosis and Inflammation of the Cardiovascular System ‐ AICS CARLO BESTA IZSME IZSME Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Bioengineering Sciences and Technologies Classificazione 2° liv. Microscopic Imaging and Spectroscopy ‐ MIS* Pagina 70 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02357283 Clinical, genetic, neurophysiological and psychological predictors of medication‐overuse headache and its relapse. MONDINO GR‐2013‐ 02357290 Integrated analysis of epigenetic, genetic and phosphoproteomic profiles for pathway‐based identification of druggable targets in individual glioblastoma stem‐like cells GR‐2013‐ 02357294 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Michele Biomedica Risk, Prevention and Health Behavior Risk, Prevention and Intervention for Addictions ‐ RPIA Istituto Superiore di Sanita' Signore Michele Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP THE ROLE OF EXOSOMES IN AMYOTROPHIC LATERAL SCLEROSIS PATHOGENESIS IZSPLV Grifoni Silvia Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02357296 Correlation between cardiovascular imaging and Mediator expression in endothelial progenitor cells: a new diagnostic integrated tool SDN Schiano Concetta Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS GR‐2013‐ 02357326 Potential efficacy of compounds influencing reactive oxygen species for treatment of pediatric T‐ALL I. O. V. silic‐benussi micol Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP GR‐2013‐ 02357327 The complex interplay between microbiota and the mucus system in intestinal tumorigenesis I.E.O. Saccheri Fabiana Biomedica Digestive, Kidney and Urological Systems Gastrointestinal Mucosal Pathobiology ‐ GMPB GR‐2013‐ 02357336 Novel therapeutic perspectives for angioedema associated BURLO GAROFALO with C1‐inhibitor deficiency or angiotensin converting enzyme‐inhibitor treatment Bossi Fleur Clinico‐ Vascular and Hematology assistenzial e Vascular Cell and Molecular Biology ‐ VCMB GR‐2013‐ 02357341 I.N.R.C.A. Evaluation of effect of mindfulness therapy and holistic psychotherapy on quality of life and anxiety and immune parameters of patients affected by tumors. Ottaviani Marica Clinico‐ Risk, Prevention and assistenzial Health Behavior e Behavioral Medicine: Interventions and Outcomes ‐ BMIO GR‐2013‐ 02357356 Evaluation of the role of the anti‐JC virus (JCV) SAN RAFFAELE MILANO neutralizing humoral response in the risk stratification for progressive multifocal leukoencephalopathy (PML) of multiple sclerosis patients on natalizumab therapy. Mancini Nicasio Biomedica Virology A and B Study Sections ‐ VIRA and VIRB Viana Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Infectious Diseases and Microbiology Pagina 71 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02357358 DEVELOPMENT OF A NEW MOUSE MODEL ACTIVELY RECAPITULATING HUMAN PEMPHIGUS FOR THE PRE‐CLINICAL EVALUATION OF INNOVATIVE THERAPIES. Emilia‐Romagna GR‐2013‐ 02357360 Development of neutralinzing antibodies blocking key steps of Staphylococcus aureus infection to be used as combined cocktail immunotherapy. Istituto Superiore di Sanita' zamboni GR‐2013‐ 02357371 Long non coding RNAs as biomarkers and therapeutic targets in multiple myeloma Calabria GR‐2013‐ 02357395 Lymphoplasmacytic lymphoma: genomic landscape and clonal evolution GR‐2013‐ 02357396 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Roberta Biomedica Immunology Hypersensitivity, Autoimmune, and Immune silvia Biomedica Infectious Diseases and Microbiology Drug Discovery and Mechanisms of Antimicrobial Resistance ‐ DDR Amodio Nicola Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP Lombardia Roccaro Aldo Maria Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC Autophagic vacuolar myopathies: gene identification by next generation sequencing CARLO BESTA Ruggieri Alessandra Biomedica Musculoskeletal, Oral and Skin Sciences Skeletal Muscle Biology and Exercise Physiology ‐ SMEP GR‐2013‐ 02357397 DISSECTING THE ROLE OF MESENCHYMAL CIRCULATING TUMOR CELLS IN COLORECTAL CANCER METASTASIS HUMANITAS CELESTI GIUSEPPE Biomedica Oncology 1 ‐ Basic Translational Tumor Progression and Metastasis ‐ TPM2 GR‐2013‐ 02357415 INDIVIDUAL PHENOTIPIC CHARACTERIZATION OF PATIENTS WITHIN THE FRONTOTEMPORAL LOBAR DEGENERATION/MOTOR NEURON DISEASE SPECTRUM USING MULTIMODAL MRI SAN RAFFAELE MILANO Canu Elisa Clinico‐ Biobehavioral and assistenzial Behavioral Processes e Adult Psychopathology and Disorders of Aging ‐ APDA GR‐2013‐ 02357418 Molecular characterization and targeting of quiescent cancer stem cells from colorectal cancer Istituto Superiore di Sanita' Francescangeli Federica Biomedica Basic Mechanisms of Cancer Therapeutics ‐ BMCT GR‐2013‐ 02357433 NEURAL AND SOCIAL IMPACT OF COGNITIVE REMEDIATION TRAINING IN SCHIZOPHRENIA AND BIPOLAR DISORDER Veneto Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Lotti Perlini Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Cinzia Oncology 2 ‐ Translational Clinical Pathophysiological Basis of Mental Disorders and Addictions ‐ PMDA Pagina 72 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02357434 Mucosal immunity predictors of HPV‐related ano‐ cervical lesions in HIV infected women: an immunological study. Lombardia sabbatini francesca Biomedica GR‐2013‐ 02357437 CLINICAL AND PROGNOSTIC ROLE OF CARDIOPULMONARY EXERCISE TEST IN THE MANAGEMENT OF MODERATE‐TO‐SEVERE AORTIC STENOSIS SAN DONATO Bandera Francesco Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR GR‐2013‐ 02357447 Transcranial direct current stimulation combined with bimanual intensive training in children with unilateral cerebral palsy CARLO BESTA Baranello Giovanni Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Developmental Brain Disorders ‐ DBD GR‐2013‐ 02357449 Effects of incretin‐based therapies on cellular markers of endothelial function/dysfunction (EPCs/MCPs) and on cognitive impairment in type 2 diabetic patients Abruzzo FORMOSO GLORIA Biomedica Vascular and Hematology Atherosclerosis and Inflammation of the Cardiovascular System ‐ AICS GR‐2013‐ 02357450 A NOVEL MYOELECTRIC CONTROLLED VIRTUAL REALITY INTERFACE FOR EFFECTIVE UPPER LIMB MOTOR RECOVERY OF STROKE PATIENTS SANTA LUCIA Berger Denise Jennifer Biomedica Integrative, Functional, and Cognitive Neuroscience Sensorimotor Integration ‐ SMI GR‐2013‐ 02357451 PRECLINICAL EVALUATION OF SMALL MOLECULE SIRT6 INHIBITORS AS CHEMOSENSITIZERS IN MULTIPLE MYELOMA IRCCS AOU San Martino‐ IST (Genova) cea michele Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB GR‐2013‐ 02357454 Cerebellar tDCS as a challenge for gait recovery in cerebellar degenerative diseases. Comparative study to address treatment efficacy SANTA LUCIA Masciullo Marcella Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02357455 A cell based assay to test antifibrotic drugs CARLO BESTA Gibertini Sara Biomedica Musculoskeletal Tissue Engineering ‐ MTE Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. AIDS and Related Research Musculoskeletal, Oral and Skin Sciences AIDS‐Associated Opportunistic Infections and Cancer ‐ AOIC Pagina 73 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02357464 Role of metabolic defects related to intracellular lipid storage in early‐onset neurodegenerative dementia and their implications for diagnosis and treatment. GR‐2013‐ 02357467 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Cupidi Chiara Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN CROB Characterization of the potential oncogenic role of gamma chain (gc) by exploring its modulatory activity on genes related to growth signaling, cell cycle control and survival, and through its post‐transcriptional miRNAs‐ mediated regulation. Fusco Anna Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC GR‐2013‐ 02357469 Coding‐ and non‐coding RNAs in B cells from multiple sclerosis patients. SANTA LUCIA Annibali Viviana Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT GR‐2013‐ 02357475 (hiSHOC) HCV‐INDUCED SEIZING OF THE HOST CELL: IMPLICATIONS FOR PATHOGENESIS AND THERAPY Veneto Gualtiero Alvisi Biomedica Infectious Diseases and Microbiology Virology A and B Study Sections ‐ VIRA and VIRB GR‐2013‐ 02357486 SAN RAFFAELE MILANO "THE ROLE OF 124‐IODINE/CG250 PET IMAGING TECHNIQUE IN DETECTING LYMPH NODE METASTASES IN RENAL CELL CARCINOMA PATIENTS" capitanio umberto Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Medical Imaging ‐ MEDI GR‐2013‐ 02357489 Establishment of three‐dimensional organoids from patient‐derived colorectal cancer xenografts Istituto Oncologico Candiolo di Blasio Laura Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME GR‐2013‐ 02357503 Long term efficacy and safety of second generation antipsychotics in children and adolescents: an active pharmacovigilance and pharmacogenetic study. MEDEA Pozzi Marco Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD GR‐2013‐ 02357507 Diagnostic accuracy and cost‐effectiveness of Next Generation Sequencing (NGS) strategies in the genetic testing of Rare Orthopaedic Diseases RIZZOLI Pedrini Elena Clinico‐ Genes, Genomes and assistenzial Genetics e Calabria Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Genomics, Computational Biology and Technology ‐ GCAT Pagina 74 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO Classificazione 1 Liv. Classificazione 2° liv. GR‐2013‐ 02357513 Role of Cardiac Stromal Cells in the pathogenesis of Arrhythmogenic Right Ventricular Cardiomyopathy MONZINO Sommariva Elena Biomedica Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF GR‐2013‐ 02357519 The Stem cell sEcretome for doxorubicin‐induced Cardiomyopathy REgeneraTion (SECRET) IRCCS AOU San Martino‐ IST (Genova) Tasso Roberta Biomedica Cell Biology Intercellular Interactions ‐ ICI GR‐2013‐ 02357521 Novel in‐vitro model approach: tissue engineering tools to study the epigenetic of endothelial cells in atherosclerosis development SAN MATTEO Pellegata Alessandro Filippo Biomedica Genes, Genomes and Genetics Molecular Genetics ‐ MGA GR‐2013‐ 02357525 Challenging new epigenetic vulnerabilities in human chemo‐resistant breast cancer metastasis. I.E.O. Cicalese Angelo Biomedica Oncology 1 ‐ Basic Translational Cancer Genetics ‐ CG GR‐2013‐ 02357526 SANTA LUCIA Depression and adult neurogenesis: a multi‐approach investigation on the role of the Wnt pathway target‐gene Math1 in the pathogenesis of Major Depressive Disorder. Saraulli Daniele Biomedica Brain Disorders and Clinical Neuroscience Neural Basis of Psychopathology, Addictions and Sleep Disorders ‐ NPAS GR‐2013‐ 02357528 Upper limb impairment in Charcot‐Marie‐Tooth patients: DON GNOCCHI evaluation of motor strategies and effectiveness of rehabilitation treatments by means of an innovative instrumental protocol. Pazzaglia Costanza Clinico‐ Musculoskeletal, Oral and assistenzial Skin Sciences e GR‐2013‐ 02357536 The stroke‐prone rat as a new experimental model of anti‐ AUXOLOGICO phospholipid syndrome: pathogenic and therapeutic effects of antibodies against different B2 glycoprotein I epitopes Chighizola Cecilia Beatrice Biomedica Calabria mignogna chiara Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Immunopathology and Immunotherapy ‐ CII MAUGERI Pagano Gennaro Clinico‐ Biology of Development assistenzial and Aging e Aging Systems and Geriatrics ‐ ASG GR‐2013‐ 02357545 GR‐2013‐ 02357549 DESTINATARIO ISTITUZIONALE AREA P.I. Tumor microenvironment in oral squamous cell cancer (OSCC). Impact of insulin‐resistance on phenotype and progression of Parkinson's Disease Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Immunology Musculoskeletal Rehabilitation Sciences ‐ MRS Hypersensitivity, Autoimmune, and Immune Pagina 75 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA GR‐2013‐ 02357554 The role of HTR2B/G‐alpha/Hippo signaling in progression and therapy response of uveal melanoma IRCCS AOU San Martino‐ IST (Genova) Amaro Adriana Agnese Biomedica GR‐2013‐ 02357556 Metaphoric speech processing in Schizophrenia: repairing a neural connectivity breakdown. SANTA LUCIA Ribolsi Michele GR‐2013‐ 02357559 DCMNET ‐ Interdisciplinary network for the prognostic stratification of patients affected by Idiopatic Dilated Cardiomyopathy Friuli‐Venezia Giulia Aleksova GR‐2013‐ 02357560 Genetic and antigenic characterisation of emerging ruminant pestiviruses threatening farm and animal production in an endemic area IZSUM GR‐2013‐ 02357561 P.I. Classificazione 1 Liv. Classificazione 2° liv. Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP Biomedica Brain Disorders and Clinical Neuroscience Neural Basis of Psychopathology, Addictions and Sleep Disorders ‐ NPAS Aneta Biomedica Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF Petrini Stefano Biomedica Veterinary Animal Health ‐ ANHE Deep genetic and phenotypic characterization of Autism Istituto Scienze Spectrum Disorder (ASD) families: analysis of the nuclear Neurologiche and mitochondrial genome Rochat Magali Jane Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD GR‐2013‐ 02357563 Can exposures to pesticides and solvents trigger the MS relapse? MAUGERI Oddone Enrico Clinico‐ Population Sciences and assistenzial Epidemiology e Neurological, Aging and Musculoskeletal Epidemiology ‐ NAME GR‐2013‐ 02357566 Impact of carotid revascularization on cognitive performances in patients with "asymptomatic" carotid stenosis: a novel multimodal brain neuroimaging approach SANTA LUCIA Cacciari Claudia Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02357585 Molecular characterization of NSCLC treated with tyrosine kinase inhibitors on the basis of EGFR status: sensitivity mechanisms for EGFR wild type tumors and resistance markers for EGFR mutated disease Istituto Scientifico Romagnolo Ulivi Paola Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02357587 Investigating the role of bcl‐2 and cancer stem cells in non‐small cell lung cancer REGINA ELENA D'aguanno Simona Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 76 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02357588 Development of double‐acting apoferritin nanoparticles for nuclear delivery of anthracyclines in HER2 positive breast cancer Lombardia Mazzucchelli Serena Biomedica Oncology 2 ‐ Translational Clinical Developmental Therapeutics ‐ DT GR‐2013‐ 02357597 Disinfectants in sustainable aquaculture: an integrated study of the pathological, genetic and enzymatic effects on aquatic organisms. IZSPLV Varello Katia Biomedica Veterinary Animal welfare ‐ ANWE GR‐2013‐ 02357598 PUSHING STEM CELL EXTRACELLULAR VESCICLES TOWARD A NEUROREGENERATIVE ASSET MAGGIORE Barilani Mario Biomedica Molecular, Cellular, and Developmental Neuroscience Neurodifferentiation, Plasticity, and Regeneration ‐ NDPR GR‐2013‐ 02357600 IL‐27 and IL‐30 receptors as novel therapeutic targets in human breast cancer GASLINI Cocco Claudia Biomedica Oncology 2 ‐ Translational Clinical Developmental Therapeutics ‐ DT GR‐2013‐ 02357601 DECA‐Designing adapted Environment for Children with STELLA MARIS Autism Narzisi Antonio Biomedica Healthcare Delivery and Methodologies Biomedical Computing and Health Informatics ‐ BCHI GR‐2013‐ 02357602 Modeling TDP43 properties through synaptic activity: from neuronal function to neurodegeneration. SANTA LUCIA Nutini Michele Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02357603 Characterisation of different clinical phenotypes in Duchenne muscular dystrophy Istituto Scienze Neurologiche Sarajlija Jasenka Clinico‐ Musculoskeletal, Oral and assistenzial Skin Sciences e Musculoskeletal Rehabilitation Sciences ‐ MRS GR‐2013‐ 02357604 Rainbow trout as translational model for human non‐IgE‐ IZSPLV mediated immune adverse reactions to food Colussi Silvia Biomedica Digestive, Kidney and Urological Systems Gastrointestinal Mucosal Pathobiology ‐ GMPB GR‐2013‐ 02357605 Identification of novel treatment tools for Castration‐ Resistant Prostate Cancer by use of a specific‐designed Zebrafish animal model Dicitore Alessandra Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Molecular and Cellular Endocrinology ‐ MCE AUXOLOGICO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 77 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02357609 Istituto Superiore di Sanita' PIERI ANALYSIS OF CIRCULATING MICRORNAS IN CEREBROSPINAL FLUID OF AMYOTROPHIC LATERAL SCLEROSIS. GR‐2013‐ 02357614 Eye Movement Desensitization and Reprocessing (EMDR) therapy in Treatment Resistant Depression (TRD): efficacy, epigenetic biomarkers and gene expression profiles. FATEBENEFRATELLI GR‐2013‐ 02357616 New moral‐psychological testing materials GR‐2013‐ 02357621 MicroRNA profiling for identification of breast cancer patients at high risk to develop distant metastases: uncovering clinical suitability and functional role of microRNAs in breast cancer. GR‐2013‐ 02357622 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. MASSIMO Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN Minelli Alessandra Biomedica Risk, Prevention and Health Behavior Behavioral Medicine: Interventions and Outcomes ‐ BMIO NEUROLESI Recupero Angela Monica Clinico‐ Integrative, Functional, assistenzial and Cognitive Neuroscience e Cognitive Neuroscience ‐ COG CASA SOLLIEVO SOFFERENZA Barbano Raffaela Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS CD157 in tumor‐microenvironment crosstalk: from Piemonte biology to potential clinical applications in ovarian cancer Morone Simona Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME GR‐2013‐ 02357624 Extracellular matrix cues and tumor angiogenesis: role of C.R.O. AVIANO EMILIN2 in regulating endothelial cell behavior Paulitti Alice Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME GR‐2013‐ 02357631 Acute coronary syndromes and clinical outcome: the role MONZINO of nitric oxide synthesis in red blood cells Cosentino Nicola Biomedica Cardiovascular and Respiratory Sciences Myocardial Ischemia and Metabolism ‐ MIM GR‐2013‐ 02357637 Molecular and biological markers in laryngeal squamous cell carcinoma, is it time for a new targeted therapy?Thymidylate synthase, PI3K, PTEN, AKT, epidermal growth factor receptor and NOTCH are important factors for tumor cell proliferation. Improvemen Tagliabue Marta Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e I.E.O. Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Cancer Biomarkers ‐ CBSS Pagina 78 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02357638 Targeting miRNAs for therapy and molecular imaging of chronic inflammatory diseases of large vessels ARCISPEDALE Croci Stefania Biomedica Vascular and Hematology Vascular Biology Special Emphasis Panel ‐ SEVB GR‐2013‐ 02357640 Clinical impact of modifiable causes of resistant hypertension: an intervention aimed at improving sleep quality and adherence to treatment Toscana Bruno Rosa Maria Biomedica Cardiovascular and Respiratory Sciences Clinical and Integrative Cardiovascular Sciences ‐ CICS GR‐2013‐ 02357643 Development of an Anti‐Corruption Controlling System (CCS) Through Implementation of an Operational Corruption Controlling Tool (OCCT) Applied to the Healthcare Procurement Process. Sicilia Pietrosi Astrid Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD GR‐2013‐ 02357645 Perfusion MRI and immunological features of anti‐Hu REGINA ELENA antibody associated paraneoplastic neurological syndrome Plantone Domenico Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02357648 STUDY OF THE USE OF ESTROGENS IN THE PHARMACOLOGICAL MODULATION OF PARVALBUMIN SYSTEM IN ANIMAL MODELS OF NEURODEGENERATION Lazio MARCHESE ELISA Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND GR‐2013‐ 02357653 Detection of molecular fingerprinting predictive of human colon cancer progression and search of miRNA‐ fusion gene pairs by a Systems Biology approach CASA SOLLIEVO SOFFERENZA Panza Anna Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS Lazio Capriotti Anna Laura Biomedica Bioengineering Sciences and Technologies Gene and Drug Delivery Systems ‐ GDD GR‐2013‐ 02357658 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. GR‐2013‐ 02357661 Cost‐effectiveness of psychoeducational treatment in children with Tourette Spectrum Disorders (TSD) Puglia Craig Francesco Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD GR‐2013‐ 02357665 Exploring the role of the P2X7 purinoceptor in cancer cachexia. SAN RAFFAELE PISANA Vitiello Laura Biomedica Skeletal Muscle Biology and Exercise Physiology ‐ SMEP Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Musculoskeletal, Oral and Skin Sciences Pagina 79 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02357686 In vivo evaluation of the process of Epithelial‐ Mesenchymal and Mesenchymal‐Epithelial transition (EMT‐MET) in Hepatocellular Carcinoma (HCC) dissemination and metastasization. MAGGIORE Colombo Federico Simone Biomedica Oncology 1 ‐ Basic Translational Tumor Progression and Metastasis ‐ TPM2 GR‐2013‐ 02357692 Tumor infiltrating lymphocytes (TILs) and melanoma: prognostic markers and new terapeutic targets ISTITUTO DERMOPATICO DELL'IMMACOLATA nardinocchi lavinia Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB GR‐2013‐ 02357694 Next Generation Sequencing for the detection of gene(s) and novel therapeutic targets in psoriasis‐related pathologies GASLINI Rusmini Marta Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD GR‐2013‐ 02357695 Innovative therapeuthic strategies for treatment of Gilles Sicilia de la Tourette Syndrome and Tic Disorders: effects of repetitive Transcranial Magnetic Stimulation (rTMS) and transcranial direct current stimulation (tDCS) Giglia Giuseppe Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02357696 New strategy for a high throughput screening (HTS) with Emilia‐Romagna stable shRNA lentivirus infection for discovery of new drug targets in multiple myeloma. STORTI PAOLA Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC GR‐2013‐ 02357698 Integrative profiling of rare diseases by whole genome and transcriptome sequencing SAN RAFFAELE MILANO Cittaro Davide Biomedica Genes, Genomes and Genetics Genomics, Computational Biology and Technology ‐ GCAT GR‐2013‐ 02357704 Impact of atherosclerotic markers and functional arterial parameters in influencing the outcome of patients with mild‐moderate carotid disease. SANTA LUCIA Altamura Claudia Clinico‐ Vascular and Hematology assistenzial e Atherosclerosis and Inflammation of the Cardiovascular System ‐ AICS GR‐2013‐ 02357705 Overcoming Drug Resistance in Neuroblastoma IRCCS AOU San Martino‐ IST (Genova) Parodi Federica Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP GR‐2013‐ 02357706 Gene expression profiling of the crosstalk between glioblastoma tumor cells and endothelial cells in neoplastic angiogenesis SANTA LUCIA MONGIARDI MARIA PATRIZIA Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 80 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02357707 COMBINATION OF NEUROPHYSIOLOGICAL AND NEUROIMAGING TECHNIQUES TO INVESTIGATE ALTERED BRAIN NETWORKS AND MOTOR PLANNING SECONDARY TO TRAUMATIC BRAIN INJURY (TBI) GR‐2013‐ 02357709 Umbria Increasing Value and Reducing Waste in Biomedical Research: Study Design, Conduct, Analysis and Publication Bias of Protocols and Funded Projects in Italy. GR‐2013‐ 02357710 Agents bearing N‐phenylbenzamide moieties as a novel pharmacological approach for the treatment of Hodgkin lymphoma GR‐2013‐ 02357713 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Gazzellini Simone Clinico‐ Integrative, Functional, assistenzial and Cognitive Neuroscience e Cognitive Neuroscience ‐ COG Luchetta Maria Laura Clinico‐ Healthcare Delivery and assistenzial Methodologies e Research on Ethical Issues in Human Studies ‐ REHS Stolfa Diana Antonella Biomedica Semiquantitative parameters generated by 68Ga‐ Liguria DOTATOC PET/CT scan and assessment of somatostatin receptors profile as prognostic and predictive tools in neuroendocrine tumors giovannini elisabetta Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Oncology 2 ‐ Translational Clinical Small Business [SBIR/STTR] Radiation Therapy and Biology ‐SETA] GR‐2013‐ 02357714 TERT promoter mutations, expression and localization in MAGGIORE differentiated thyroid cancer and thyroid cancer stem cells Muzza Marina Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP GR‐2013‐ 02357715 Effects of plasma components in circulating chronic lymphocytic leukemia cell survival: a role in the B‐cell receptor inhibitors era C.R.O. AVIANO BENEDETTI DANIA Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME GR‐2013‐ 02357716 Role of the purinergic receptor P2X7 in the pathogenesis of atherosclerosis. SAN RAFFAELE PISANA Gorini Stefania Biomedica Cardiovascular and Respiratory Sciences Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR GR‐2013‐ 02357719 TrueHeart: A novel 3D cardiac biomimetic system fully recapitulating adult heart physiology and muscular dystrophy pathology. MONZINO Gowran Aoife Biomedica Cardiovascular and Respiratory Sciences Cardiovascular Differentiation and Development ‐ CDD OSPEDALE BAMBINO GESU' ONCOLOGICO DI BARI Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Oncology 2 ‐ Translational Clinical Drug Discovery and Molecular Pharmacology ‐ DMP Pagina 81 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02357725 Deciphering the cardiac sodium channel interactome to understand the molecular pathogenesis of cardiac arrhythmias and to develop novel diagnostic and therapeutic tool to prevent sudden death SDN Detta Nicola GR‐2013‐ 02357726 Role of interleukin‐33 in the development of gastritis, epithelial proliferation and gastric neoplasia SAN DONATO Pisani Laura Francesca Biomedica GR‐2013‐ 02357740 Role of coronary ion channels in the crass‐talk between myocardial needs and coronary blood flow. A possible culprit in ischemic heart disease? Lazio Mancone Massimo Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Myocardial Ischemia and Metabolism ‐ MIM GR‐2013‐ 02357751 Veneto Genetics of severe obesity in children and adolescents: assessing the prevalence of known Mendelian forms, and discovering new genes associated with monogenic obesity by whole exome sequencing followed by co‐ segregation, case‐control and functional anal Morandi Anita Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD GR‐2013‐ 02357756 Targeted inhibition of HIV‐1 Tat and Interferon regulatory factor (IRF)‐1 physical and functional interaction as a novel anti‐HIV‐1 therapeutic strategy. Istituto Superiore di Sanita' REMOLI ANNA LISA Biomedica AIDS and Related Research AIDS Discovery and Development of Therapeutics ‐ ADDT GR‐2013‐ 02357757 Biostatistical methods for meta‐analyzing individual participant data in diagnostic and prognostic research, with application to the role of cerebrospinal fluid biomarkers in Parkinson's disease. Umbria Paolo Clinico‐ Healthcare Delivery and assistenzial Methodologies e Biostatistical Methods and Research Design ‐ BMRD GR‐2013‐ 02357760 Non‐peptidic ligands of G protein couple receptors FPRs in human glioblastomas: an immunopharmacological target for development of new therapeutic approaches. Istituto Superiore di Sanita' Ricci Alessandro Biomedica Tumor Progression and Metastasis ‐ TPM2 GR‐2013‐ 02357762 RELATIONSHIP BETWEEN OSTEOPOROSIS AND CARDIOVASCULAR RISK IN PATIENTS WITH THALASSEMIA MAJOR Toscana Antonella Clinico‐ Vascular and Hematology assistenzial e Eusebi Meloni Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Biomedica Classificazione 1 Liv. Classificazione 2° liv. Cardiovascular and Respiratory Sciences Electrical Signaling, Ion Transport, and Arrhythmias ‐ ESTA Digestive, Kidney and Urological Systems Gastrointestinal Mucosal Pathobiology ‐ GMPB Oncology 1 ‐ Basic Translational Clinical Hematology Special Emphasis Pane ‐SECHl Pagina 82 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02357764 The addition of simvastatin portal venous infusion to cold storage solution of explanted whole liver grafts for facing ischemia/reperfusion injury in an area with low rate of deceased donation Sicilia PAGANO DUILIO Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Surgery, Anesthesiology, and Trauma ‐ SAT GR‐2013‐ 02357768 miR‐17‐92 and methylation status alterations in response to neadjuvant chemo‐radiotherapy in rectal cancer Istituto Scientifico Romagnolo Molinari Chiara Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02357785 Genetic characterization of inflammatory damage on corneal limbal epithelial stem cells and setting up of innovative non surgical therapeutic strategies. Abruzzo Curcio Claudia Biomedica Cell Biology Cellular Signaling and Regulatory Systems ‐ CSRS GR‐2013‐ 02357788 Safe Follow‐up after EndoVascular Aortic Repair (EVAR) SAN DONATO with Non‐contrast magnetic resonance imaging (NCMRI) and Color‐flow Duplex Ultrasound (CDU): Diagnostic Accuracy, Cost‐effectiveness Analysis, and Impact on Patient Management (the SAFEVAR study) Secchi Francesco Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Medical Imaging ‐ MEDI GR‐2013‐ 02357789 Performance evaluation of clinical pathways in cancer patients: an innovative model of governance Istituto Scientifico Romagnolo Altini Mattia Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD GR‐2013‐ 02357793 To study the potential mission of cancer stem cells as early pre‐cancerous traits and biomarkers of progression from liver fibrosis to hepatocellular carcinoma OSPEDALE BAMBINO GESU' Ceccarelli Sara Biomedica Hepatobiliary Pathophysiology ‐ HBPP GR‐2013‐ 02357797 Pretreatment staging of gastric cancer in the era of neoadjuvant chemotherapy: a prospective multicentre study finalised to validate the accuracy of MDCT and the feasibility of Computed Tomography perfusion imaging in the preoperative CT staging and resta Toscana Mazzei Maria Antonietta Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Oncology 2 ‐ Translational Clinical Small Business [SBIR/STTR] Radiation Therapy and Biology ‐SETA] GR‐2013‐ 02357805 Glial‐mediated inflammation underlying neurodegeneration in Mucopolysaccharidosis type II epitomizes a common causal path in the development of major neurodegenerative diseases CASA SOLLIEVO SOFFERENZA Zalfa Maria Cristina Biomedica Cell Death in Neurodegeneration ‐ CDIN Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Digestive, Kidney and Urological Systems Brain Disorders and Clinical Neuroscience Pagina 83 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02357813 E.L.I.S.A. projectA multicomponent intervention for End‐of‐Life care Implementation in end Stage organ failure of Aging from hospital to home I.N.R.C.A. SORVILLO FRANCESCA Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD GR‐2013‐ 02357814 Cell signaling modulators to counteract to the oncogenic potential of gonadotropins. Emilia‐Romagna Casarini Livio Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Molecular and Cellular Endocrinology ‐ MCE GR‐2013‐ 02357815 iPSC technology: a useful model to understand the molecular and cellular mechanisms of ageing and Parkinson's disease. OSPEDALE BAMBINO GESU' Compagnucci Claudia Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND GR‐2013‐ 02357820 Can EEG biomarkers predict and optimize effectiveness of robot‐assisted therapy? MAUGERI Sterpi Irma Biomedica Brain Disorders and Clinical Neuroscience Brain Injury and Neurovascular Pathologies ‐ BINP GR‐2013‐ 02357821 An Italian study on intermediate‐lenght polyQ‐tract expansions: frequency, clinical variability, and brain morphometry of subjects at risk for late‐onset neurodegenerative diseases. CARLO BESTA Nanetti Lorenzo Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02357825 Zebrafish: an intriguing model to investigate the role of cancer stem cells in thyroid carcinomas. MAGGIORE Cirello Valentina Biomedica Tumor Progression and Metastasis ‐ TPM2 GR‐2013‐ 02357827 Effects of early seizure onset and seizure persistence on brain connectivity in young children with tuberous sclerosis complex: a diffusion tensor and functional MR study OSPEDALE BAMBINO GESU' Moavero Romina Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Developmental Brain Disorders ‐ DBD GR‐2013‐ 02357828 Pathogenesis, diagnosis and prognosis of non alcoholic fatty liver disease (NAFLD): the role of lipid related molecular inflammatory pathways in the evolution to steatohepatitis and in the development of cardiovascular diseases. New perspectives for a non Veneto Pesce Paola Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Oncology 1 ‐ Basic Translational Pagina 84 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02357830 TRAIL, THE REGULATION OF BODY WEIGHT AND METABOLISM, AND ITS INTERACTION WITH THYROID HORMONES AND METFORMIN. BURLO GAROFALO Bernardi Stella Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Molecular and Cellular Endocrinology ‐ MCE GR‐2013‐ 02357833 Function of ISWI in nucleoplasm compartments organization and its role in alternative splicing of oncogenic isoforms Sicilia Onorati Maria Cristina Biomedica Genetics of Health and Disease ‐ GHD GR‐2013‐ 02357837 Allogeneic Hematopoietic Stem Cell Transplantation for Refractory Immune‐mediated Neurological Diseases SAN RAFFAELE MILANO Greco Raffaella Clinico‐ Vascular and Hematology assistenzial e Hematopoiesis ‐ HP GR‐2013‐ 02357839 OSPEDALE BAMBINO Mitochondrial encephalocardiopathies: an integrated clinical and molecular approach to implement the genetic GESU' diagnosis Diodato Daria Clinico‐ Genes, Genomes and assistenzial Genetics e Genetics of Health and Disease ‐ GHD GR‐2013‐ 02357840 Targeted therapy with Ruxolitinib in Myelofibrosis: a novel characterization of the inflammatory microenvironment Emilia‐Romagna PALANDRI FRANCESCA Biomedica Cell Biology Intercellular Interactions ‐ ICI GR‐2013‐ 02357850 New players in tuberculosis vaccine development: mycobacterial small regulatory RNAs for attenuating virulence of Mycobacterium tuberculosis SAN RAFFAELE MILANO Miotto Paolo Biomedica Infectious Diseases and Microbiology Host Interactions with Bacterial Pathogens ‐ HIBP GR‐2013‐ 02357872 Immuno ‐ Metabolic Targeting of Tumor Microenvironment in Ewing's Sarcoma (IMMETTE) Emilia‐Romagna Grisendi Giulia Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME GR‐2013‐ 02357875 Metabolomics and cardiovascular function in the offspring of patients with premature coronary artery disease: a study for the early identification of high risk subjects for myocardial infarction Veneto Castaldi Biagio Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS GR‐2013‐ 02357880 Effect of tailored communication on MMR vaccination uptake and timeliness: a Randomized Controlled Trial Puglia Martinelli Domenico Clinico‐ Healthcare Delivery and assistenzial Methodologies e Community‐Level Health Promotion ‐ CLHP Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Genes, Genomes and Genetics Classificazione 2° liv. Pagina 85 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02357882 Blood viscosity and thrombophilic pattern in obstructive sleep apnea SAN DONATO Baryshnikova Ekaterina Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS GR‐2013‐ 02357885 Endovascular therapy in acute ischemic stroke: an observational prospective study of an inter‐provincial Hub and Spoke Model Emilia‐Romagna Zini Andrea Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Acute Neural Injury and Epilepsy ‐ ANIE GR‐2013‐ 02357891 Vibriosis in aquaculture settings: new tools and markers for the control of animal diseases and human exposure IZSVE CABURLOTTO GRETA Biomedica Veterinary Animal Health ‐ ANHE GR‐2013‐ 02357894 Iper‐expression of insulin receptor in breast cancer: role of the transcription factors AP‐2¿ and p53. Calabria arcidiacono biagio Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB GR‐2013‐ 02357902 Role of melanocortin receptors in vascular remodeling MONZINO Saporiti Federica Biomedica Vascular and Hematology Vascular Biology Special Emphasis Panel ‐ SEVB GR‐2013‐ 02357903 Investigation of the apoptosis‐independent functions of Mcl‐1 in the regulation of mTOR, LDHB and NPM1 and their contribution to Mcl‐1‐driven tumorigenesis. I.E.O. Elgendy Mohamed Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC GR‐2013‐ 02357904 EFFECTS OF LOW‐FREQUENCY STN‐DBS STIMULATION ON LATE‐EMERGING AXIAL SYMPTOMS AND COGNITION IN PARKINSON'S DISEASE. Emilia‐Romagna PREDA FRANCESCA Clinico‐ Emerging Technologies and Brain Disorders and assistenzial Training in Neurosciences Related e Neurosciences Fellowship ‐ F01 GR‐2013‐ 02357906 Selection of biomarkers actionable with targeted agents to define a bio‐clinical and therapeutic algorithm for metastatic colorectal cancer (MCRC) patients. Abruzzo Bruera Gemma Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02357907 The developmental role of the endocannabinoid system in metabolic syndrome and co‐morbid neuropsychiatric disturbances: fundamental mechanisms and therapeutic potential Istituto Superiore di Sanita' Macri Simone Biomedica Biobehavioral and Behavioral Processes Biobehavioral Mechanisms of Emotion, Stress and Health ‐ MESH Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 86 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02357919 Prophylactic bilateral salpingectomy as the new strategy for preventing ovarian cancers: safety confirmation, educational campaign and assessment of the prevalence of tubal precancerous lesions in healthy women are the three essential steps for changing s Calabria Venturella Roberta Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC GR‐2013‐ 02357922 Effects of a Mediterranean‐ style diet on non‐alcoholic fatty liver disease in patients with type 2 diabetes. SDN Lutgarda Bozzetto Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Diabetes, Metabolism, Nutrition and Obesity Small Business SEP (EMNR E10 B) GR‐2013‐ 02357923 Emilia‐Romagna Identification of the prognostic and predictive value of pre‐specified biomarkers and gene sets in stage III‐IV epithelial ovarian cancer specimens from patients treated with neoadjuvant platinum‐taxane chemotherapy: a biomarker sub‐study of GOGER‐01 rand Barbieri Elena Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02357924 Combined PET/MRI brain imaging as marker of dementia in Parkinson's disease SDN Erro Roberto Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02357928 Targeting Protein kinase C Epsilon (PKCe) as a novel therapeutic strategy in Primary Myelofibrosis Emilia‐Romagna Masselli Elena Biomedica Vascular and Hematology Hematopoiesis ‐ HP GR‐2013‐ 02357934 REDOX MECHANISMS REGULATE PROLIFERATION AND CHEMIORESISTANCE OF GASTROINTESTINAL CANCER STEM CELLS Lazio Puglisi Maria Ausiliatrice Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB GR‐2013‐ 02357939 Molecular bases of Female Epilepsy with Mental Retardation (EFMR) and Rett syndrome (RTT): targeting common mechanisms underlying two X‐linked neurological disorders of young girls characterized by brain hyper‐excitability. HUMANITAS Bassani Silvia Biomedica Molecular, Cellular, and Developmental Neuroscience Synapses, Cytoskeleton and Trafficking ‐ SYN Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 87 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02357948 PROGNOSTIC VALUE OF MOLECULAR ALTERATIONS Lombardia IN GASTRIC CANCER: OVERALL SURVIVAL IN PATIENTS LIVING IN CREMONA AREA WITH OVEREXPRESSION OF MET, FGFR AND OCT1 GR‐2013‐ 02357955 Diagnostic integration of clinical flow cytometry with Raman spectroscopy: an innovative approach for diagnosis of human acute leukemia GR‐2013‐ 02357959 Role of the adipocyte mineralocorticoid receptor in the development of sarcopenic obesity and comorbidities GR‐2013‐ 02357960 Development and validation of a dermo‐epidermal Emilia‐Romagna biological skin substitute for the treatment of severe burns GR‐2013‐ 02357964 Protocadherin 19 (PCDH19) related epilepsy as X‐linked model of neurological disorder: from inherited base to therapy. GR‐2013‐ 02357967 Rescue of Transforming‐Growth‐Factor‐beta 1 pathway as Associazione Oasi Maria SS Caraci a new strategy for neuroprotection in Alzheimer's disease: role of second‐generation antidepressant drugs GR‐2013‐ 02357968 Biology beyond second primary melanomas in metastatic ARCISPEDALE patients treated with Selective BRAF Inhibitors (SBI). GR‐2013‐ 02357978 Dissecting susceptibility to cardiometabolic disease in Brisighella study using genomic and metagenomic approaches GR‐2013‐ 02357981 Unraveling the role of Fanconi anemia proteins in mitochondria for novel therapeutic approaches AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. TOPPO LAURA Clinico‐ Oncology 1 ‐ Basic assistenzial Translational e Cancer Molecular Pathobiology ‐ CAMP SDN Mirabelli Peppino Biomedica Bioengineering Sciences and Technologies Microscopic Imaging and Spectroscopy ‐ MIS* SAN RAFFAELE PISANA Feraco Alessandra Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative Physiology of Obesity and Diabetes ‐ IPOD PURPURA VALERIA Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Bioengineering, Technology, and Surgical Sciences ‐ BTSS Terracciano Alessandra Biomedica Brain Disorders and Clinical Neuroscience Acute Neural Injury and Epilepsy ‐ ANIE Filippo Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN moscarella elvira Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS Emilia‐Romagna Rosticci Martina Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD BURLO GAROFALO Ravera Silvia Biomedica Cell Biology Nuclear and Cytoplasmic Structure/Function and Dynamics ‐ NCSD OSPEDALE BAMBINO GESU' Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 88 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA GR‐2013‐ 02357989 Metastatic progression of breast cancer: targeting the insulin receptors ‐ microenvironment connection Sicilia Nicolosi Maria Luisa Biomedica Oncology 1 ‐ Basic Translational Tumor Progression and Metastasis ‐ TPM2 GR‐2013‐ 02357998 PERIOPERATIVE MARKERS AND CLINICAL FOLLOW‐ UP OF NEUROLOGICAL AND LUNG INJURY IN INFANTS WITH CONGENITAL HEART DISEASES. Veneto Simonato Manuela Biomedica Cardiovascular and Respiratory Sciences Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR GR‐2013‐ 02357999 Production of autologous antigen‐specific T lymphocytes Toscana using iPSC technology. Focosi Daniele Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII GR‐2013‐ 02358002 COronary plaque evolUtion: in vivo invasive and non invasive assessment of coronary PLaquE progression and correlation with biohumoral markers (COUPLE) De Caterina Alberto Ranieri Clinico‐ GR‐2013‐ 02358012 Functional discovery of new drug‐targetable genes for the C.R.O. AVIANO cure of CRC patients Rizzolio GR‐2013‐ 02358017 The Annexin A5 and the obstetric outcome in general pregnant population: Insights into molecular and functional analysis of a novel risk factor for thrombosis and pregnancy complications. CASA SOLLIEVO SOFFERENZA GR‐2013‐ 02358026 Melanopsin retinal ganglion cells and circadian rhythms: function and dysfunction in Alzheimer's disease and aging. GR‐2013‐ 02358031 Nosocomial infections, antibiotic‐resistance and the possible new therapeutic use of an extract of the isothiocyanate Glucomoringin purified by Moringa oleifera seeds. P.I. Classificazione 1 Liv. Classificazione 2° liv. Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS Flavio Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC Tiscia Giovanni Luca Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Pregnancy and Neonatology ‐ PN Istituto Scienze Neurologiche La Morgia Chiara Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN NEUROLESI Galuppo Maria Letteria Clinico‐ Infectious Diseases and assistenzial Microbiology e Toscana Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Drug Discovery and Mechanisms of Antimicrobial Resistance ‐ DDR Pagina 89 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA GR‐2013‐ 02358032 Investigating the interplay between mesenchymal stromal Emilia‐Romagna cells and hematopoietic stem cells in leukemia development and outcome Ciciarello Marilena Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME GR‐2013‐ 02358035 Harness the power of RIP3 as modulator of cell death pathways in colorectal cancer therapy CROB pescatore alessandra Biomedica Cell Biology Cellular Signaling and Regulatory Systems ‐ CSRS GR‐2013‐ 02358036 Long‐term efficacy of a novel simplified, minimally‐ invasive procedure for sinus floor elevation in the atrophic posterior maxilla: a multicenter, randomized study. Emilia‐Romagna Farina Roberto Clinico‐ Musculoskeletal, Oral and assistenzial Skin Sciences e GR‐2013‐ 02358038 Retention in Care (RiC) in Persons Living With HIV SPALLANZANI (PLWH): current dynamics in Italy, and evaluation of a long‐term sustainable intervention for increasing RiC and reducing lost‐to‐follow‐up. Fusco Francesco Maria Clinico‐ GR‐2013‐ 02358039 Targeted Therapy With or Without Nephrectomy in Metastatic Renal Cell Carcinoma: Liquid Biopsy for Biomarkers Discovery ISTITUTO TUMORI MILANO Verzoni Elena GR‐2013‐ 02358041 A wearable myocontrolled neuroprosthesis for the recovery of hand functions understanding the mechanisms of action of training mediated by functional electrical stimulation in individuals with stroke MAUGERI Ambrosini GR‐2013‐ 02358048 Characterization of human adipose tissue microbiota and AUXOLOGICO its relation with adipose tissue gene expression and cardio‐metabolic diseases GR‐2013‐ 02358058 alpha4beta1 integrin‐mediated endothelial cell adhesion to EMILIN1 gC1q domain: implications in tissue engineered vascular grafts GR‐2013‐ 02358059 Preclinical and clinical development of a novel class of ligand‐based CXCR4 ‐inhibitor cyclic peptides P.I. Classificazione 1 Liv. Classificazione 2° liv. Oral, Dental and Craniofacial Sciences ‐ ODCS AIDS and Related Research AIDS Clinical Studies and Epidemiology ‐ ACE Biomedica Oncology 2 ‐ Translational Clinical Clinical Oncology ‐ CONC Emilia Biomedica Emerging Technologies and Brain Disorders and Training in Neurosciences Related Neurosciences Fellowship ‐ F01 Zulian Alessandra Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO C.R.O. AVIANO Capuano Alessandra Biomedica Vascular and Hematology Vascular Cell and Molecular Biology ‐ VCMB PASCALE Ieranò Caterina Biomedica Oncology 2 ‐ Translational Clinical Developmental Therapeutics ‐ DT assistenzial e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 90 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02358064 MicroRNA: powerfull biomarker for monitoring and predict response to preoperative chemoradiotherapy in rectal cancer patients. Veneto Maretto Isacco Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS GR‐2013‐ 02358065 Dissecting the role of TRIM proteins as autophagy regulators in human genetic rare diseases CASA SOLLIEVO SOFFERENZA Fusco Carmela Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD GR‐2013‐ 02358068 "Novel strategies to combat gynaecological tumors: targeting of metabolism, cell invasion and chemoresistance" CROB AMOROSO MARIA ROSARIA Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB GR‐2013‐ 02358074 The pathogenesis of Hereditary Spastic Paraplegia: role of MEDEA Endoplasmic Reticulum morphological alterations Pendin Diana Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN GR‐2013‐ 02358086 BILATERAL STRIATAL NECROSIS : PHENOTYPES DELINATION AND IDENTIFICATION OF NEW GENOTYPES Tonduti Davide Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02358093 Characterization of new pathways potentially involved in Sicilia Human Hepatocellular Carcinoma prevention and treatment Miceli Vitale Biomedica Cancer Molecular Pathobiology ‐ CAMP GR‐2013‐ 02358096 The ion torrent platform utilization for the microbial biodiversity in perimplantitis: application of a new technology based on Next generation Sequencing BURLO GAROFALO Mazzoni Annalisa Clinico‐ Infectious Diseases and assistenzial Microbiology e Bacterial Pathogenesis ‐ BACP GR‐2013‐ 02358098 Mapping spatial neglect symptoms in the brain: A study combining behavioural data, functional neuroimaging, and computational modelling SANTA LUCIA Nardo Davide Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Brain Injury and Neurovascular Pathologies ‐ BINP GR‐2013‐ 02358110 Human organotypic vascularized microfluidic 3D models GALEAZZI for investigating novel endothelial targets to prevent bone metastatic invasion from breast cancer Arrigoni Chiara Biomedica Tumor Microenvironment ‐ TME CARLO BESTA Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Oncology 1 ‐ Basic Translational Oncology 1 ‐ Basic Translational Classificazione 2° liv. Pagina 91 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02358111 Analysis of gene expression noise at the single cell level in SANTA LUCIA lymphoblastoid cell lines (LCLs) obtained from identical twins dscordant for multiple sclerosis (MS), unrelated MS patients and healthy controls. ricigliano vito antonio gerardo Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT GR‐2013‐ 02358113 Bone Marrow Fibroblast: Focus on Multiple Myeloma progression. ONCOLOGICO DI BARI Serratì Simona Biomedica Vascular and Hematology Vascular Cell and Molecular Biology ‐ VCMB GR‐2013‐ 02358118 Elucidating neuroimaging biomarkers of vascular parkinsonism for better prediction of cognitive and behavioral outcomes. SANTA LUCIA Assogna Francesca Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02358124 Pain control in patients with bone metastases treated with magnetic resonance imaging‐guided high intensity focused ultrasound (MR‐HIFU) Istituto Scientifico Romagnolo Ricci Marianna Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Medical Imaging ‐ MEDI GR‐2013‐ 02358125 ATP7B multiple rare gene variants in the susceptibility for SAN RAFFAELE PISANA Alzheimer's Disease. Bucossi Serena Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD GR‐2013‐ 02358133 Evaluation of the anti‐inflammatory and immunomodulatory activity of Mesenchymal Stem/Stromal Cell‐derived Extracellular Vesicles in an animal model of ulcerative colitis OSPEDALE BAMBINO GESU' Del Fattore Andrea Biomedica Immunology Immunology Fellowships and Area ‐ F07 GR‐2013‐ 02358134 CARDIO‐PUZZLE solving tool: interpreting genetic heterogeneity in cardiomyopathies. From single nucleotide to single genome, passing through massive parallel sequencing. SAN MATTEO Favalli Valentina Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD GR‐2013‐ 02358143 New perspectives for radiotherapy: development of a laser‐based technology for electrons and gamma‐rays generation. Characterization and dosimetry towards the transfer for radiotherapy of cancer. Toscana Baffigi Federica Biomedica Oncology 2 ‐ Translational Clinical Radiation Therapeutics and Biology ‐ RTB GR‐2013‐ 02358144 PERSPECT ‐ A new perspective for 99mTc Molecular Imaging Emilia‐Romagna CICORIA GIANFRANCO Biomedica Bioengineering Sciences and Technologies Instrumentation and Systems Development ‐ ISD Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 92 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02358169 Presepsin (soluble CD14 subtype) for the diagnosis of sepsis and monitoring of antibiotic treatment in preterm newborns: a multicenter prospective study. Toscana Poggi Chiara Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS GR‐2013‐ 02358172 Use of granulocyte‐colony stimulating factor to decrease post operative complications after hepatectomy. A prospective multicenter, double‐blind, placebo‐ controlled study. Emilia‐Romagna Alessandro Cucchetti Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Hepatobiliary Pathophysiology ‐ HBPP GR‐2013‐ 02358176 Piemonte EVALUATION OF OUTCOMES OF HIGH RISK NON MUSCLE‐INVASIVE BLADDER CANCER (NMIBC) UNDERGOING RE‐TRANSURETHRAL RESECTION (RE‐ TUR) PLUS STANDARD TREATMENT OR TREATMENT ALONE: A RANDOMIZED PROSPECTIVE TRANSLATIONAL RESEARCH STUDY Oderda Marco Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS GR‐2013‐ 02358177 Multimodal experimental and theoretical approach for the study of the Spinal Cord in healthy and diseased subjects SANTA LUCIA Fratini Michela Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Medical Imaging ‐ MEDI GR‐2013‐ 02358179 New insight on interactions between gut microbiota and osteoporosis: an in vitro and in vivo study to develop novel biotherapeutic approaches GALEAZZI Toscano Marco Biomedica Musculoskeletal, Oral and Skin Sciences Skeletal Biology Development and Disease ‐ SBDD GR‐2013‐ 02358180 Molecular alterations and clinical features associated with Toscana progression of myelodysplastic syndromes to myelodysplastic syndromes/ myeloproliferative neoplasms Valencia Martinez Ana Belen Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02358181 Study of the mechanisms responsible for the increased Emilia‐Romagna breast cancer risk and reduced tumor chemosensitivity in obese and type 2 diabetes people: role of the interleukin 6 BRIGHENTI ELISA Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP GR‐2013‐ 02358182 Circulating microRNAs, lifestyle factors, and their interaction in the aetiology, diagnosis and prognosis of Soft Tissue Sarcoma Galeone Carlotta Biomedica Population Sciences and Epidemiology Epidemiology of Cancer ‐ EPIC MARIO NEGRI Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 93 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02358185 Optimized cost‐efficacy of HCV treatment with direct‐ acting antivirals: a model‐based approach trained by outcomes from the real practice Istituto Superiore di Sanita' Giovanetti GR‐2013‐ 02358191 Neuromodulation in pediatric focal cortical dysplasia: focus on GABAergic transmission SAN RAFFAELE PISANA GR‐2013‐ 02358192 Vitamin D in the prevention of subclinical and advanced atheromatosis. GR‐2013‐ 02358196 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Marta Biomedica Infectious Diseases and Microbiology Clinical Research and Field Studies of Infectious Diseases ‐ CRFS roseti cristina Biomedica Brain Disorders and Clinical Neuroscience Acute Neural Injury and Epilepsy ‐ ANIE BURLO GAROFALO Arcidiacono Maria Vittoria Biomedica Vascular and Hematology Atherosclerosis and Inflammation of the Cardiovascular System ‐ AICS Next Generation Sequencing for genetic abnormalities responsible for Atypical Chronic Myeloid Leukemia Lombardia Donadoni Carla Biomedica Oncology 1 ‐ Basic Translational Cancer Genetics ‐ CG GR‐2013‐ 02358213 Monitoring the molecular evolution of lung cancer by liquid biopsy to model the proper targeted treatment strategy. Sicilia Bronte Giuseppe Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02358216 Innate Immunity and Natural History of Hepatitis C Virus Toscana Infection in Children INDOLFI GIUSEPPE Biomedica Infectious Diseases and Microbiology Virology A and B Study Sections ‐ VIRA and VIRB GR‐2013‐ 02358219 A Pioneering Neuroadaptive Personalized Therapy for Memory Preservation SAN RAFFAELE PISANA INFARINATO FRANCESCO Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02358222 Immunogenic cell death as novel immune response mechanism to EGFR‐targeted therapy in Colorectal Cancer I.E.O. Pozzi Chiara Clinico‐ Immunology assistenzial e Cellular and Molecular Immunology A ‐ CMIA GR‐2013‐ 02358223 In search of new sets of genomic and phenotypic markers CROB for the diagnosis of myelodysplastic syndromes: a novel discovery approach based on high throughput flow cytometry and RNA sequencing. D'Auria Fiorella Biomedica Cancer Biomarkers ‐ CBSS Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Oncology 2 ‐ Translational Clinical Pagina 94 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02358225 CELLULAR AND MOLECULAR APPROACH TO STUDY NEW PATHWAYS INVOLVED IN IMMUNE DYSREGULATION: WHOLE EXOME SEQUENCING IN IPEX‐LIKE PATIENTS Toscana Vignoli Marina GR‐2013‐ 02358227 A phase II, prospective, pilot study of anakinra in asbestosis SAN RAFFAELE MILANO Dagna Lorenzo GR‐2013‐ 02358229 Multimodal investigation of biomarkers in patients with Alzheimer's disease DON GNOCCHI Morasso Carlo Francesco Biomedica GR‐2013‐ 02358234 Personalized chemotherapy for bone metastatic NSCLC patients based on patient‐specific microfluidic in vitro screening SAN RAFFAELE MILANO Bulotta Alessandra Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC GR‐2013‐ 02358238 Peripheral blast clearance analysis during induction treatment in patients with acute myeloid leukemia Toscana Mannelli Francesco Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC GR‐2013‐ 02358241 A pilot study of the clinical efficacy and safety of faecal microbial transplantation for the decolonization of hospitalized patients harboring enteric KPC‐producing Klebsiella pneumoniae Lombardia bisi luca Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS GR‐2013‐ 02358247 Resolving the perivascular extracellular matrix regulation C.R.O. AVIANO of pericyte‐driven tumor dissemination for therapeutic targeting of cell‐microenvironment interactions Marastoni Stefano Biomedica Tumor Microenvironment ‐ TME GR‐2013‐ 02358249 Biological, clinical and neuro‐imaging markers of unstable plaque in patients with asymptomatic carotid artery stenosis Toscana nesi mascia Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02358260 A new mouse model of spontaneous prion diseases: following the path from structural determinants to toxicity and therapeutics Istituto Superiore di Sanita' Pirisinu Laura Biomedica Cell Death in Neurodegeneration ‐ CDIN Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD Biomedica Cardiovascular and Respiratory Sciences Lung Injury, Repair, and Remodeling ‐ LIRR Bioengineering Sciences and Technologies Microscopic Imaging and Spectroscopy ‐ MIS* Oncology 1 ‐ Basic Translational Brain Disorders and Clinical Neuroscience Pagina 95 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02358262 The sense of number in Developmental Dyscalculia STELLA MARIS Anobile GR‐2013‐ 02358271 Reduction of post‐MI events in smoking cessation programs using e‐cigs: a randomized controlled trial Sicilia GR‐2013‐ 02358272 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Developmental Brain Disorders ‐ DBD CAPONNETT PASQUALE O Clinico‐ Risk, Prevention and assistenzial Health Behavior e Behavioral Medicine: Interventions and Outcomes ‐ BMIO Evaluation of a novel nano‐material as wound dressing to Toscana prevent surgical site infections caused by Methicillin Resistant Staphylococcus Aureus (MRSA) strains. Morandi Matteo Biomedica Nanotechnology ‐ NANO GR‐2013‐ 02358284 Financial Abilities in pathological aging S.CAMILLO Arcara Giorgio Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02358285 NR4A in autoimmune and neurodegenerative disease: a translational approach from mouse to man Piemonte Montarolo Francesca Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT GR‐2013‐ 02358288 Preliminary Studies for Boron Neutron Capture Therapy application to Osteosarcoma Calabria Galasso Olimpio Biomedica Oncology 2 ‐ Translational Clinical Radiation Therapeutics and Biology ‐ RTB GR‐2013‐ 02358289 Pro‐inflammatory interleukin‐18 and phosphoinositide‐ dependent protein kinase‐1 regulation of cardiac contractility HUMANITAS Monasky Michelle Biomedica Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF GR‐2013‐ 02358290 Diagnostic significance and pathogenic role of anti‐KIR4.1 Piemonte potassium channel antibodies in Multiple Sclerosis. Marnetto Fabiana Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT GR‐2013‐ 02358291 Copy number variations at the GFAP locus and GASLINI deregulated GFAP expression as possible pathogenic mechanisms causing or modifying the disease phenotype in Alexander disease DI ZANNI ELEONORA Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Giovanni Bioengineering Sciences and Technologies Pagina 96 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA GR‐2013‐ 02358292 Prospective randomized study of diagnostic accuracy comparing prostate cancer detection by transrectal ultrasound‐guided biopsy versus Magnetic Resonance Imaging (MRI) with selective MR‐guided biopsy in men with negative biopsy and suspected prostate canc I.E.O. PETRALIA GIUSEPPE GR‐2013‐ 02358293 Transcranial Direct Current Stimulation (tDCS) for disabling tremor resistant to therapy: a randomized, double blind, crossover, placebo controlled clinical trial MONDINO Pozzi Nicolò Gabriele Clinico‐ GR‐2013‐ 02358296 MicroRNA miR‐590‐3p and prostaglandin F2alpha receptor (FP) expression in healthy subjects and in patients with essential hypertension Lazio Mucci Luciana GR‐2013‐ 02358299 Emilia‐Romagna Correlation between motor awareness and motor symptoms in Parkinson's Disease: a possile role of mental practice GR‐2013‐ 02358302 Role of microbial co‐factors in persistency of cervico‐ vaginal HPV‐infection, virus‐induced inflammation and epithelial cell damage GR‐2013‐ 02358306 Manipulating iron homeostasis in multiple myeloma: a novel strategy of potential therapeutic value GR‐2013‐ 02358315 GR‐2013‐ 02358319 P.I. Classificazione 1 Liv. Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Classificazione 2° liv. Renal and Urological Sciences Small Business Activities ‐ SERU Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN Clinico‐ Vascular and Hematology assistenzial e Vascular Cell and Molecular Biology ‐ VCMB FIORAVANTI VALENTINA Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN Toscana CLEMENTE ANN MARIA Biomedica Infectious Diseases and Microbiology Infectious Diseases and Microbiology Fellowship ‐ F13 SAN RAFFAELE MILANO Campanella Alessandro Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME Pain in knee osteoarthritis, a placebo‐controlled RIZZOLI randomized clinical trial for a new potential therapeutic approach: magnetic resonance guided focused ultrasound surgery (MRgFUS) Bazzocchi Alberto Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Medical Imaging ‐ MEDI CARLO BESTA Whole Exome Next‐Generation Sequencing in patients with Ruptured and Unruptured Intracranial Aneurysm: a pilot study to identify genetic variants associated with risk of aneurysm rupture (ANEURYSK). Acerbi Francesco Clinico‐ Genes, Genomes and assistenzial Genetics e Genetics of Health and Disease ‐ GHD Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 97 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02358321 immune system disregulation and neurodevelopmental disorders: the search for peripheral markers in tourette syndrome and early onset psychosis Puglia PETRUZZELLI MARIA GIUSEPPINA Biomedica Biobehavioral and Behavioral Processes Child Psychopathology and Developmental Disabilities ‐ CPDD GR‐2013‐ 02358322 Circulating Tumour Cells: a tool for the discovery of novel biomarkers and drug development targets in bone sarcoma PASCALE Bifulco Katia Biomedica Oncology 1 ‐ Basic Translational Tumor Progression and Metastasis ‐ TPM2 GR‐2013‐ 02358324 The role of non‐coding RNAs in the development of atherosclerosis and vascular complications in diabetes Calabria De Rosa Salvatore Biomedica Cardiovascular and Respiratory Sciences Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR GR‐2013‐ 02358326 Metabolomic Fingerprint for Cognitive impairment in Hypertension. NEUROMED SELVETELLA GIULIO Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS GR‐2013‐ 02358327 Biomarkers of haemorragic trasformation in patients with NEUROMED ischaemic stroke. Landolfi Alessandro Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02358334 non‐coding RNAs as Pulmonary neuroendocrine(NE) tumors biomarkers Valerio Biomedica Genes, Genomes and Genetics Molecular Genetics ‐ MGA GR‐2013‐ 02358340 IZSVE Searching for new/undetected viruses transmitted by native and invasive mosquitoes and identification of their ecological cycle including potential animal reservoirs Ravagnan Silvia Biomedica Veterinary Animal Health ‐ ANHE GR‐2013‐ 02358353 A perspective longitudinal cohort study on the molecular Lombardia and clinical effects of HIV antiretroviral treatment with protease inhibitors on HPV‐related malignancies. Mazza Francesca Biomedica Oncology 2 ‐ Translational Clinical Drug Discovery and Molecular Pharmacology ‐ DMP Provincia autonoma Trento Del Vescovo Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 98 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02358354 Indicated prevention with long‐chain polyunsaturated omega‐3 fatty acids in patients with22q11 microdeletion syndrome genetically at high risk for psychosis: A randomised, doubleblind, placebo‐controlled treatment trial. OSPEDALE BAMBINO GESU' Armando Marco Biomedica Biobehavioral and Behavioral Processes Child Psychopathology and Developmental Disabilities ‐ CPDD GR‐2013‐ 02358360 Interaction of environmental and ecological factors on spillover risk of West Nile and Usutu viruses in humans in Northern Italy IZSPLV Pautasso Alessandra Biomedica Veterinary Animal Health ‐ ANHE GR‐2013‐ 02358363 Preclinical development of a novel and target‐specific compound that kills melanoma cells through a death receptor Emilia‐Romagna Truzzi Francesca Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT GR‐2013‐ 02358364 Bone Pre‐Metastatic niche: the role of exosomes in the crosstalk between breast cancer cells and osteoclasts Istituto Scientifico Romagnolo Mercatali Laura Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME GR‐2013‐ 02358366 Theranostic applications in pancreatic cancer disease: a new way to drive targeted therapies. Sicilia TARANTINO GAETANA ILARIA Biomedica Oncology 2 ‐ Translational Clinical Developmental Therapeutics ‐ DT GR‐2013‐ 02358367 Early neuromuscular and psychophysiological biomarkers SANTA LUCIA for the prevention of falls risk in neurological diseases and brain ageing: Training anticipatory cognitive brain functions Berchicci Marika Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02358368 ROLE OF ANOCTAMINS IN NEURO‐MUSCULAR DISEASES Sondo Elvira Biomedica Cell Biology Membrane Biology and Protein Processing ‐ MBPP GR‐2013‐ 02358377 Toscana Second and third generation sequencing in genetic diagnosis of rare diseases: the model of Marfan syndrome and related disorders Sticchi Elena Biomedica Genes, Genomes and Genetics Genomics, Computational Biology and Technology ‐ GCAT GR‐2013‐ 02358386 An elastic polymeric mesh as an external supports for the Toscana prevention of intimal hyperplasia in by‐pass vein grafts Losi Paola Biomedica Bioengineering Sciences and Technologies Biomaterials and Biointerfaces ‐ BMBI GASLINI Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 99 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02358391 The hypoxia inducible factor (HIF)‐1 alpha as a potential target in combination with new drugs for the therapy of multiple myeloma. Emilia‐Romagna Bolzoni Marina Biomedica GR‐2013‐ 02358395 The prognostic value of a Multidimensional Prognostic Index (MPI) in elderly hospitalized patients undergoing cardiac invasive procedures Emilia‐Romagna BERTINI MATTEO Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS GR‐2013‐ 02358399 SAN MATTEO Identification and characterization of human broadly neutralizing antibodies against human coronaviruses and human parainfluenza viruses Piralla Antonio Biomedica Small Business: Non‐ HIV Anti‐Infective Therapeutics ‐ SBN GR‐2013‐ 02358410 ADHD and epilepsy comorbidity: safety and risk assessment in children receiving methylphenidate or atomoxetine treatment. STELLA MARIS Pellacani Simona Clinico‐ Biobehavioral and assistenzial Behavioral Processes e Child Psychopathology and Developmental Disabilities ‐ CPDD GR‐2013‐ 02358412 Hepatitis E, an emerging zoonotic disease: immunity, pathogenesis and novel reservoirs. Istituto Superiore di Sanita' Di Bartolo Ilaria Biomedica Infectious Diseases and Microbiology Fellowship ‐ F13 GR‐2013‐ 02358418 Run the risk in breast cancer: the impact of genetic risk in I.E.O. individual and familial decision making processes Riva Silvia Clinico‐ Risk, Prevention and assistenzial Health Behavior e SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan ‐ TPM1 GR‐2013‐ 02358420 Computer‐aided tools to support identification and CARLO BESTA connectivity of the area of seizures generation in epileptic patients submitted to pre‐surgical intracranial EEG monitoring Bellistri Elisa Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Acute Neural Injury and Epilepsy ‐ ANIE GR‐2013‐ 02358428 RE‐ASSESSMENT OF THE RISK FACTORS FOR INVASIVE FUNGAL INFECTION IN LIVER TRANSPLANTATION BASED ON THE MODEL FOR END‐STAGE LIVER DISEASE (MELD) SCORE Bartoletti Michele Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS Emilia‐Romagna Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Oncology 1 ‐ Basic Translational Infectious Diseases and Microbiology Infectious Diseases and Microbiology Classificazione 2° liv. Tumor Progression and Metastasis ‐ TPM2 Pagina 100 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02358430 NEUROMASTER: NEUROnavigated MAgnetic STimulation in patients with mild‐moderate Alzheimer disease combined with Effective cognitive Rehabilitation SAN RAFFAELE PISANA Vecchio Fabrizio Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02358431 Multiple primary tumours after breast cancer: the role of environment and therapies, and possible genetic and epigenetic risk markers Piemonte Ricceri Fulvio Biomedica Population Sciences and Epidemiology Epidemiology of Cancer ‐ EPIC GR‐2013‐ 02358432 Chronic Kidney Disease evaluation in high risk subjects, Sicilia nephropatic patients and transplant recipients: Diffusion tensor imaging, Elastography, urinary microRNAs and biomarkers of Fibrosis allow Early diagnosis, renal and Allograft survival improvement a Lacquaniti Antonio Biomedica Digestive, Kidney and Urological Systems Renal and Urological Sciences Small Business Activities ‐ SERU GR‐2013‐ 02358437 Macrocephaly‐Autism‐Epilepsy Phenotype (MAEP) STELLA MARIS spectrum: multimodal assessment of neuroanatomical, neurophysiological and molecular underpinnings of brain dysfunctions. Valvo Giulia Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD GR‐2013‐ 02358440 Controlling the liposome‐protein corona for its exploitation in targeted therapy Lazio Caracciolo Giulio Biomedica Bioengineering Sciences and Technologies Biomaterials and Biointerfaces ‐ BMBI GR‐2013‐ 02358442 Optimization of the cardiac network in the Lazio region: appropriateness, timeliness and equity in access to emergency care. Lazio Mataloni Francesca Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD GR‐2013‐ 02358448 Circulating microRNAs, salivary biomarkers (microRNAs, OSPEDALE BAMBINO proteins and microbiota) coupled to clinical and GESU' telehomecare data as innovative diagnostic tools for fibromialgia syndrome. Baldassarre Antonella Biomedica Arthritis, Connective Tissue and Skin ‐ ACTS GR‐2013‐ 02358449 Affective dysregulation in Bipolar and Borderline Personality Disorders: a common feature with different patterns. A multidimensional study with the Experience Sampling Method and physiological monitoring. Candini Valentina Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e FATEBENEFRATELLI Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Musculoskeletal, Oral and Skin Sciences Classificazione 2° liv. Pathophysiological Basis of Mental Disorders and Addictions ‐ PMDA Pagina 101 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02358450 Mindfulness‐based cognitive behavioural therapy for obsessive‐compulsive disorder: a randomized controlled trial on the clinical outcomes and the underlying neural mechanisms of change FATEBENEFRATELLI Lanfredi Mariangela Biomedica GR‐2013‐ 02358453 Coronary CT Angiography and CT perfusion imaging in Type‐2 diabetic patients with endothelial dysfunction Lazio Pirro Federica Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Myocardial Ischemia and Metabolism ‐ MIM GR‐2013‐ 02358454 The novel candidate tumor suppressor gene ADAR2 as a new therapeutic target for glioblastoma multiforme (GBM) OSPEDALE BAMBINO GESU' Tomaselli Sara Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP GR‐2013‐ 02358457 In vitro differentiation of placenta stem cells into mature Sardegna functional hepatocytes and in vivo application for the treatment of liver based metabolic diseases Marongiu Fabio Biomedica Digestive, Kidney and Urological Systems Hepatobiliary Pathophysiology ‐ HBPP GR‐2013‐ 02358460 COMBINED MOLECULAR AND IMMUNOLOGICAL STRATEGIES FOR OUTCOME PREDICTION AND THERAPY OF ACUTE AND CHRONIC HEPATITIS C VIRUS INFECTIONS Barili Valeria Biomedica Immunology Immunity and Host Defense ‐ IHD GR‐2013‐ 02358466 Investigation of human epileptic networks by fMRI based Emilia‐Romagna effective connectivity: a new approach to identify the neuronal drivers of the pathological activity in surgically remediable epilepsies. Vaudano Anna‐Elisabetta Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02358468 Nanoparticles‐ encapsulating Zoledronic Acid in combination therapy as a new strategy for glioblastoma treatment REGINA ELENA Porru Manuela Biomedica Oncology 2 ‐ Translational Clinical Developmental Therapeutics ‐ DT GR‐2013‐ 02358470 Circulating micro‐RNAs as novel biomarkers in Malignant Pleural Mesothelioma Toscana BONOTTI ALESSANDRA Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02358472 DON GNOCCHI Neural manual vs. robotic assisted mobilization to improve motion and reduce pain hypersensitivity in hand osteoarthritis: a randomized controlled trial. VILLAFANE JORGE HUGO Clinico‐ Musculoskeletal, Oral and assistenzial Skin Sciences e Emilia‐Romagna Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Brain Disorders and Clinical Neuroscience Neural Basis of Psychopathology, Addictions and Sleep Disorders ‐ NPAS Musculoskeletal Rehabilitation Sciences ‐ MRS Pagina 102 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02358475 Evaluation of the impact of functional and volumetric tools on the DIaGnostic confidence of physicians in the diagnosis of Alzheimer's Disease (DIG‐AD) FATEBENEFRATELLI Redolfi Alberto Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02358489 A proinflammatory role of proNGF and of the p75NTR receptor in chronic arhtiris: a novel targettable pathway for novel therapies OSPEDALE BAMBINO GESU' Minnone Gaetana Biomedica Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ‐ ACTS GR‐2013‐ 02358492 Placenta derived Mesenchymal Stromal Cells as new Piemonte therapeutic tools to deliver anti‐inflammatory signals and anti‐tumor drugs simultaneously: a preclinical study in bone sarcomas. Mareschi Katia Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME GR‐2013‐ 02358498 THE ROLE OF DEEP BRAIN STIMULATION AND ITS PARAMETER OPTIMIZATION IN MOOD AND BEHAVIORAL DISTURBANCES IN PATIENTS WITH MOVEMENT DISORDERS Fumagalli Manuela Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02358503 A comprehensive approach for the diagnosis of ultra‐rare Emilia‐Romagna diseases Magini Pamela Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD GR‐2013‐ 02358507 Development and application of a new case finding strategy for recognition of missing cases of celiac disease in Italian general practice Trifirò Gianluca Clinico‐ Population Sciences and assistenzial Epidemiology e Social Sciences and Population Studies ‐ SSPS GR‐2013‐ 02358511 Prospective evaluation of a screening methodology and of Emilia‐Romagna pathophysiological correlates in patients admitted to hospital for acute coronary syndromes and at risk of chronic obstructive pulmonary disease. CAMPO GIANLUCA CALOGERO Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS GR‐2013‐ 02358512 Risk evaluation of human exposure to ticks borne diseases (TBDs) and comparative analysis of pathogens through medical and veterinary cooperation IZSUM Antognini Elisa Biomedica Infectious Diseases and Microbiology Vector Biology ‐ VB GR‐2013‐ 02358518 Optimizing brain pre‐surgical planning in children: integration of functional and structural connectivity at high and ultra‐high field MRI STELLA MARIS Fiori Simona Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD MAGGIORE Sicilia Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 103 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02358521 FATEBENEFRATELLI A comprehensive stimulating program for MCI patients supported by pervasive healthcare technologies: cognitive training, fitness and nutritional interventions GR‐2013‐ 02358523 Modeling inflammation and oxidative stress in Rett syndrome development using a proteomic approach to identify early molecular targets GR‐2013‐ 02358524 Circulating miRNA biomarkers for defeating mortality in lung and ovarian cancer patients GR‐2013‐ 02358525 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Fostinelli Silvia Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN Toscana Cortelazzo Alessio Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND I.E.O. BIANCHI FABRIZIO Biomedica Oncology 1 ‐ Basic Translational Cancer Genetics ‐ CG A pilot study for staging schizophrenia through a multi‐ Puglia factor algorithm: implications for prediction of prognosis, clinical and functional outcome of conventional drug treatment compared to modern Cognitive Rehabilitation. RAMPINO ANTONIO Biomedica Brain Disorders and Clinical Neuroscience Pathophysiological Basis of Mental Disorders and Addictions ‐ PMDA GR‐2013‐ 02358526 DEFINING THE PERIPHERAL NERVOUS SYSTEM SAN RAFFAELE MILANO SIGNATURE IN AMYOTROPHIC LATERAL SCLEROSIS: A MAGNETIC RESONACE IMAGING AND NEUROPATHOLOGIC STUDY Riva Nilo Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02358527 IDENTIFICATION OF GENETIC MECHANISMS AND DISCOVERY OF BIOMARKERS IN FOCAL CORTICAL DYSPLASIA AND REFRACTORY EPILEPSY Emilia‐Romagna Pippucci Tommaso Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD GR‐2013‐ 02358534 TRFH domain of TRF2 as a target for drug development REGINA ELENA Salvati Erica Biomedica Cell Biology Cellular Signaling and Regulatory Systems ‐ CSRS GR‐2013‐ 02358538 The burden of HIV infection and AIDS on mortality patterns: A population‐based study in Italy C.R.O. AVIANO Zucchetto Antonella Clinico‐ AIDS and Related Research assistenzial e AIDS Clinical Studies and Epidemiology ‐ ACE GR‐2013‐ 02358539 Randomized controlled trial on the effects of STELLA MARIS methylphenidate and add‐on computer‐based working‐ memory training, on action planning, adaptive behaviour and quality of life in patients with ADHD. Belmonti Vittorio Clinico‐ Biobehavioral and assistenzial Behavioral Processes e Cognition and Perception ‐ CP Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 104 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02358548 Identification of pharmacokinetic and pharmacogenomic BURLO GAROFALO strategies for methotrexate therapy personalization in patients with Juvenile Idiopathic Arthritis Pastore Serena Biomedica GR‐2013‐ 02358549 New managerial paths and technological innovations non‐ NEUROLESI invasive for care and remote monitoring of complexes patients: Cost‐benefit analysis and home‐care. Bramanti Alessia Clinico‐ Healthcare Delivery and assistenzial Methodologies e GR‐2013‐ 02358552 High‐technology virtual‐reality surgical simulators for medical students' selection and young residents' training in neurosurgery CARLO BESTA Perin Alesandro Clinico‐ Emerging Technologies and Neurotechnology ‐ assistenzial Training in Neurosciences NT e GR‐2013‐ 02358553 Improving cancer services: integration of care evaluation and patient engagement models Emilia‐Romagna Bravi Francesca Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD GR‐2013‐ 02358556 PREDICTING THE PROGRESSION OF SUBJECTIVE COGNITIVE DECLINE AND MILD COGNITIVE IMPAIRMENT (MCI) TO DEMENTIA: THE ROLE OF COGNITIVE, BIOLOGICAL AND NEUROIMAGING MARKERS Emilia‐Romagna spallazzi marco Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN GR‐2013‐ 02358563 Involvement of beta‐adrenergic signalling in cardiac repair and regeneration Istituto Superiore di Sanita' Massimi Alessia Biomedica Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF GR‐2013‐ 02358564 High‐throughput miRNAome profiling in myasthenia gravis patients: towards the identification of pathogenic mechanisms underlying autoimmunity CARLO BESTA Cavalcante Paola Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT GR‐2013‐ 02358572 Deciphering the role of microRNAs and genomic alterations in melanoma resistance to BRAF‐targeted therapy: identification of plasma biomarkers to predict and monitor response to therapy ISTITUTO DERMOPATICO DELL'IMMACOLATA Caporali Simona Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD Biomedical Computing and Health Informatics ‐ BCHI Pagina 105 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02358575 ANTI‐CEACAM6 LIPOSOMAL IMMUNO‐ CHEMOTHERAPY OF COLORECTAL CANCER IN AN ORGAN‐ON‐CHIP DEVICE SDN Tomaiuolo Giovanna Biomedica GR‐2013‐ 02358578 Neurobiological mechanisms underlying emotion processing dysfunctions in Affective Disorders: A clinical and MRI longitudinal investigation SANTA LUCIA Basile Barbara Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Pathophysiological Basis of Mental Disorders and Addictions ‐ PMDA GR‐2013‐ 02358579 The pre‐metastatic niche formation in melanoma: role of SAN GALLICANO tumor‐derived secreted factors and myeloid derived suppressor cells in modulating and shaping the environment of secondary recurrences and clinico‐ pathlogical predictors of melanoma skip‐metastases PAOLINO GIOVANNI Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB GR‐2013‐ 02358585 Deciphering candidate susceptibility genes for familial Colorectal Cancer ISTITUTO TUMORI MILANO Signoroni Stefano Biomedica Oncology 1 ‐ Basic Translational Cancer Genetics ‐ CG GR‐2013‐ 02358594 Multi‐Omics study of spastin‐related hereditary spastic paraplegia (HSP) type 4 to help diagnosis and therapy of different penetrance and severity phenotypes STELLA MARIS Ucciferri Nadia Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02358601 Role of the endoplasmic reticulum redox regulators Ero1alpha, Peroxiredoxin4 and ERp44 in prostate cancer SAN RAFFAELE MILANO Anelli Tiziana Biomedica Cell Biology Cellular Signaling and Regulatory Systems ‐ CSRS GR‐2013‐ 02358604 Gene‐environment interactions in the etiopathogenesis of Lazio nonsyndromic craniosynostosis: towards the definition of an updated diagnostic workflow FRASSANITO PAOLO Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD GR‐2013‐ 02358606 IMPACT ON CLINICAL OUTCOME AND COSTS OF SYSTEMATIC MULTIDISCIPLINARY MANAGEMENT OF HOSPITALIZED PATIENTS WITH COMMUNITY ACQUIRED PNEUMONIA Emilia‐Romagna Giannella Maddalena Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS GR‐2013‐ 02358609 New molecular biomarkers for the diagnosis and management of pancreatic lesions Sicilia Bruno Loredana Biomedica Cancer Biomarkers ‐ CBSS Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Bioengineering Sciences and Technologies Oncology 2 ‐ Translational Clinical Gene and Drug Delivery Systems ‐ GDD Pagina 106 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02358612 Combining next‐generation sequencing and cellular studies to develop effective strategies for the identification of unconventional genetic determinants of amyotrophic lateral sclerosis GR‐2013‐ 02358613 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD Marangi Giuseppe Biomedica PEPTIDE RECEPTOR RADIONUCLIDE THERAPY WITH Istituto Scientifico 90Y‐DOTATOC IN RELAPSED/REFRACTORY DIFFUSE Romagnolo LARGE B CELL AND MANTLE CELL LYMPHOMAS. Musuraca Gerardo Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Oncology 2 ‐ Translational Clinical Small Business [SBIR/STTR] Radiation Therapy and Biology ‐SETA] GR‐2013‐ 02358619 New molecular markers for a personalized therapy in epithelial ovarian cancer C.R.O. AVIANO Sonego Maura Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02358623 Dissecting the genetic etiology of epileptic encephalopathy by next‐generation sequencing Campania Coppola Antonietta Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD GR‐2013‐ 02358631 Exploring the potentialities of lung ultrasound in pediatric cardiac surgery: an easy, fast, inexpensive, radiation‐free, but still surprisingly underutilized diagnostic tool. Toscana Giordano Raffaele Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS GR‐2013‐ 02358635 Identification of molecular and cellular therapeutic targets for the cure of psoriasis and inflammatory skin diseases SAN RAFFAELE MILANO Maina Virginia Biomedica Arthritis, Connective Tissue and Skin ‐ ACTS GR‐2013‐ 02358636 Idiopathic normal pressure hydrocephalus: new diagnostic markers for a treatable dementia. Lazio POLLI FILIPPO MARIA Clinico‐ GR‐2013‐ 02358639 i‐CLIMB project: a pilot study for the integration of CLinical, Imaging and Mechano‐Biological variables as a new paradigm for management of the dilated ascending aorta Toscana Murzi Michele Lazio Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Musculoskeletal, Oral and Skin Sciences Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS Pagina 107 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02358643 Efficacy of lymphatico‐venous anastomosis alone, autologous vascularized lymphnode transfer alone and combined lymphatico‐venous anastomosis and autologous vascularized lymphnode transfer in the treatment of breast cancer‐related lymphedema GR‐2013‐ 02358649 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Visconti Giuseppe Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Surgery, Anesthesiology, and Trauma ‐ SAT Familial pancreatic cancer: identification of high‐risk SAN MATTEO individuals.Definition of a possible screening algorithm based on clinical features, clinical genetics and molecular analysis. COBIANCHI LORENZO Biomedica Oncology 1 ‐ Basic Translational Cancer Genetics ‐ CG GR‐2013‐ 02358667 Molecular control of iNKT cell function and anergy in anti‐tumor response SAN RAFFAELE MILANO Fedeli Maya Biomedica Immunology Cellular and Molecular Immunology B ‐ CMIB GR‐2013‐ 02358668 In vivo advanced MRI markers of brain microenvironment prone to metastasis in breast and lung cancer patients. REGINA ELENA Quattrocchi Carlo Cosimo Biomedica Emerging Technologies and Brain Disorders and Training in Neurosciences Related Neurosciences Fellowship ‐ F01 GR‐2013‐ 02358672 Route to normalization: functional and structural correlates of depression remission induced by psychotherapy. SANTA LUCIA Tommasin Silvia Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02358676 Malignant melanoma: investigation of new combined targeted therapies in in vitro and in vivo models SDN Cuomo Gaia Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB GR‐2013‐ 02358677 RApid versus SLOw Withdrawal of antiepileptic Calabria monotherapy in two‐year seizure‐free adult patients with epilepsy (RASLOW Study): a pragmatic multicentre, prospective, randomized, controlled study. Ferlazzo Edoardo Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Acute Neural Injury and Epilepsy ‐ ANIE GR‐2013‐ 02358681 Prospective investigation of the relationship between C subunit of the FO ATP synthase and reperfusion injury in patients with ST‐segment elevation myocardial infarction. Bonora Massimo Biomedica Myocardial Ischemia and Metabolism ‐ MIM Lazio Emilia‐Romagna Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Cardiovascular and Respiratory Sciences Pagina 108 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02358686 SIGNOR a tool for systems approach to diagnosis and patient stratification: focus on neuromuscular disorders. SANTA LUCIA Perfetto Livia Biomedica GR‐2013‐ 02358692 Cardiac preservation with normothermic donor heart perfusion compared to standard cold storage in heart transplantation: a new standard of care to face donor shortage? Friuli‐Venezia Giulia Sponga Sandro Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Cardiovascular Sciences Small Business SECS GR‐2013‐ 02358693 Integrated network for the identification and treatment of subjects with Familial Hypercholesterolemia for the prevention of premature coronary heart disease. ARCISPEDALE Fasano Tommaso Clinico‐ Vascular and Hematology assistenzial e Atherosclerosis and Inflammation of the Cardiovascular System ‐ AICS GR‐2013‐ 02358701 Early environmental stimulation and Down syndrome: impact on neurodevelopment in children and animal models STELLA MARIS Begenisic Tatjana Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD GR‐2013‐ 02358702 Role of mitochondrial calcium in stomach and colorectal cancers Emilia‐Romagna Marchi Saverio Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC GR‐2013‐ 02358704 Application of Proteomics and Metabonomics for SANTA LUCIA neurodegenerative pathways identification linked to deep gray matter atrophy and iron deposition in Multiple Sclerosis and Parkinson's Disease patients Pisani Valerio Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02358706 Increasing diagnostic accuracy of Alzheimer¿s disease in the early stage of mild cognitive impairment through machine learning algorithms and functional connectivity measures De Marco Matteo Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02358713 Predictive impact of the immune contexture and genomic CARLO BESTA alterations in glioblastoma after dendritic cell immunotherapy Pellegatta Serena Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII S.CAMILLO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Cell Biology Molecular and Integrative Signal Transduction ‐ MIST Pagina 109 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02358714 The role of the anesthetic block of the motor branches of Istituto Scienze posterior tibial nerve in the evaluation of the spastic Neurologiche equinus pattern: validation of a surface EMG integrated protocol Milletti David Clinico‐ Musculoskeletal, Oral and assistenzial Skin Sciences e Musculoskeletal Rehabilitation Sciences ‐ MRS GR‐2013‐ 02358716 An innovative and transferable rehabilitation protocol for RIZZOLI oncology patients with skeletal reconstructions based on wearable and portable systems Valente Giordano Biomedica Musculoskeletal, Oral and Skin Sciences Musculoskeletal Rehabilitation Sciences ‐ MRS GR‐2013‐ 02358720 Etiology of cryptoglandular anal fistulas: immuno‐ pathological characterization of chronic inflammation Lazio Litta Francesco Biomedica Immunology Innate Immunity And Inflammation ‐ III GR‐2013‐ 02358723 rePLAY: a comprehensive rehabilitation theraPy tooL based on Active video game for children with cerebral palsY SANTA LUCIA Aloise Fabio Biomedica Biobehavioral and Behavioral Processes Motor Function, Speech and Rehabilitation ‐ MFSR GR‐2013‐ 02358726 RESHAPE: REstoring the Self with embodiable HAnd ProsthesEs INAIL Di Pino Giovanni Biomedica Brain Disorders and Clinical Neuroscience Acute Neural Injury and Epilepsy ‐ ANIE GR‐2013‐ 02358731 Towards improved surveillance and preparedness for West Nile Virus infections at the animal‐human interface IZSVE Mulatti Paolo Biomedica Veterinary Animal Health ‐ ANHE GR‐2013‐ 02358732 Development of a standardized WGS‐based platform for real‐time outbreak investigation and infection control practice improvement. SAN RAFFAELE MILANO Baldan Rossella Biomedica Infectious Diseases and Microbiology Clinical Research and Field Studies of Infectious Diseases ‐ CRFS GR‐2013‐ 02358737 Effects of Transcranial Direct Current Stimulation and Cognitive‐Behavioural Therapy on brain plasticity in MS: implications for the treatment of chronic pain. SANTA LUCIA Spano' Barbara Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroimmunology and Brain Tumors ‐ CNBT GR‐2013‐ 02358740 Innate Immunity and Inflammation genes: novel markers BURLO GAROFALO for preterm birth and cerebral palsy Alberini Elena Biomedica Developmental Brain Disorders ‐ DBD Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Brain Disorders and Clinical Neuroscience Classificazione 2° liv. Pagina 110 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02358746 Non‐Invasive brain stimulation combined with memory training in patients with Alzheimer¿s Disease FATEBENEFRATELLI Brambilla Michela Biomedica GR‐2013‐ 02358747 Chronic Venous Disease: a randomized study in subjects with prolonged occupational exposure to gravity. Emilia‐Romagna GIANESINI SERGIO Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health and Health Related Behavior of Individuals and Populations Fellowship ‐ F16 GR‐2013‐ 02358752 IZSUM Novel bacteriophages isolated from cheese manufacturing environments as innovative tool for Listeria monocytogenes active biocontrol in cheese plants Petruzzelli Annalisa Biomedica Veterinary Food Safety ‐ FOSA GR‐2013‐ 02358753 PARACETAMOL AND IBUPROFEN IN THE TREATMENT OF PATENT DUCTUS ARTERIOSUS: CLINICAL IMPACT AND BIOMARKERS OF EFFICACY IN TWO COHORTS OF PRETERM INFANTS. MAGGIORE ANTONIAZZI STEFANIA ADELAIDE Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Pregnancy and Neonatology ‐ PN GR‐2013‐ 02358754 Emerging ArBovirus infections: epidemiology, diagnosis and pathogenesis Emilia‐Romagna Rossini Giada Biomedica Infectious Diseases and Microbiology Infectious Diseases and Microbiology Fellowship ‐ F13 GR‐2013‐ 02358759 Clinical Impact of a Comprehensive Geriatric Assessment SAN RAFFAELE PISANA on the Elderly Patient in Oncology: Optimization of Personalized Health‐Care Programs and Diagnostic‐ Therapeutic Pathways. A Randomized Controlled Study. Dall'Armi Valentina Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD GR‐2013‐ 02358760 Hindering Abeta formation by targeting the Amyloid Precursor Protein at the beta‐secretase cleavage site MARIO NEGRI BEEG MARTEN Biomedica Drug Discovery in the Nervous System ‐ ZRG1 MNPS GR‐2013‐ 02358762 Participatory research for fine‐tuning of a 2.0 system to optimise home management of oral cancer therapies. Istituto Scientifico Romagnolo PASSARDI ALESSANDRO Clinico‐ Healthcare Delivery and assistenzial Methodologies e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Brain Disorders and Clinical Neuroscience Molecular, Cellular, and Developmental Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN Biomedical Computing and Health Informatics ‐ BCHI Pagina 111 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02358764 Validation of an Ankle Wearable Exoskeleton (AWE) prototype for gait function support and rehabilitation in children with neurological and neuromuscular diseases GR‐2013‐ 02358767 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Vasco Gessica Clinico‐ Emerging Technologies and Neurotechnology ‐ assistenzial Training in Neurosciences NT e Effect of a physical activity and health education program Lazio on functional ability, physical performance, and healthcare resource consumption in elderly subjects with metabolic syndrome. Laudisio Alice Biomedica GR‐2013‐ 02358770 Impact of methylmercury exposure on neurocognitive function in children at school age. BURLO GAROFALO mariuz marika Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Developmental Brain Disorders ‐ DBD GR‐2013‐ 02358788 New control strategies of salmonellosis in pigs based on modulation of the intestinal microbiota IZSUM Pesciaroli Michele Biomedica Animal Health ‐ ANHE GR‐2013‐ 02358789 IMPLEMENTING A POPULATION BASED RECORD LINKAGE SYSTEM OF NEUROLOGICAL DISEASES: A TOOL FOR EVALUATIVE EPIDEMIOLOGY. PARKINSON'S DISEASE AS A MODEL. Istituto Scienze Neurologiche Luciano Lorenza Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD GR‐2013‐ 02358806 Understanding neural mechanisms of Spatial Neglect by linking anatomical damage to resting state functional connectivity NEUROMED Baldassarre Antonello Biomedica Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02358807 LOW ADIPONECTIN LEVELS AS INDIPENDENT RISK MARKER FOR BREAST CANCER IN HIGH RISK POSTMENOPAUSAL WOMEN I.E.O. Macis Debora Clinico‐ Population Sciences and assistenzial Epidemiology e Epidemiology of Cancer ‐ EPIC GR‐2013‐ 02358810 SIRT1 activation as a new strategy to reduce endothelial dysfunction and thrombotic events in hetero/homozygous for Methylenetetrahydrofolate reductase (MTHFR) NEUROMED Carrizzo Albino Biomedica Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR GR‐2013‐ 02358813 MULTIethnic oriented mental health services: a CulturAl FATEBENEFRATELLI Mediation Portal ‐MULTICAMPO‐ Signorini Giulia Clinico‐ Healthcare Delivery and assistenzial Methodologies e OSPEDALE BAMBINO GESU' Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Biology of Development and Aging Veterinary Brain Disorders and Clinical Neuroscience Cardiovascular and Respiratory Sciences Aging Systems and Geriatrics ‐ ASG Health Services Organization and Delivery ‐ HSOD Pagina 112 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02358814 Impact of bone marrow microenvironment on platelet prothrombotic function: an in vitro model based on genetically engineered megakaryocytes. MONZINO Brambilla Marta Biomedica Vascular and Hematology Hemostasis and Thrombosis ‐ HT GR‐2013‐ 02358827 Real‐time fMRI‐based neurofeedback as a treatment tool for emotional deficits in bipolar disorder. SAN RAFFAELE MILANO Poletti Sara Biomedica Brain Disorders and Clinical Neuroscience Neural Basis of Psychopathology, Addictions and Sleep Disorders ‐ NPAS GR‐2013‐ 02358829 Prednisolone in cattle: OMICS strategies to differentiate between endogenous and synthetic sources IZSPB Paglia Giuseppe Biomedica Veterinary Food Safety ‐ FOSA GR‐2013‐ 02358830 IN VIVO MRI TRACKING OF MESENCHYMAL STEM CELLS USED TO CLOSE POST‐SURGICAL BRONCHO‐ PLEURAL FISTULAE: STUDIES IN AN EXPERIMENTAL ANIMAL MODEL I.E.O. Rizzo Stefania Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Biomedical Imaging Technology ‐ BMIT GR‐2013‐ 02358837 Investigating the Hippo pathway in breast cancer: identification of novel biomarkers and therapeutic strategies REGINA ELENA Maugeri‐Saccà Marcello Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS GR‐2013‐ 02358841 Amyotrophic Lateral Sclerosis and Caffeine Intake. An Italian Population‐Based Case‐Control Study MARIO NEGRI Pupillo Elisabetta Biomedica Neurological, Aging and Musculoskeletal Epidemiology ‐ NAME GR‐2013‐ 02358847 Cognitive rehabilitation after temporal lobe epilepsy surgery: outcomes and predictors. CARLO BESTA Parente Annalisa Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Acute Neural Injury and Epilepsy ‐ ANIE GR‐2013‐ 02358852 The neural markers of post‐stroke recovery: tracking the early dynamics of cortical reorganization with a novel longitudinal multimodal approach. SANTA LUCIA Bonnì Sonia Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Acute Neural Injury and Epilepsy ‐ ANIE GR‐2013‐ 02358853 'KEEPING THE BODY IN MIND': MONITORING YOUNG PEOPLE WITH MENTAL DISORDERS BEING ADMINISTERED PSYCHOTROPIC DRUGS Abruzzo Giusti Laura Biomedica Behavioral Medicine: Interventions and Outcomes ‐ BMIO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Population Sciences and Epidemiology Risk, Prevention and Health Behavior Classificazione 2° liv. Pagina 113 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02358857 ATM HETEROZYGOSITY AS A MAJOR‐TUMOR SUSCEPTIBILITY FACTOR IN THE GENERAL POPULATION REGINA ELENA Prodosmo Andrea Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB GR‐2013‐ 02358859 Development of a new diagnostic tool for early diagnosis and prognosis of colorectal cancer Emilia‐Romagna BERTOLINI FEDERICA Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02358862 DEVELOPMENT OF INNOVATIVE ANALYTICAL METHODS FOR MEAT PRODUCTS SAFETY AND QUALITY ASSURANCE IZSPB Iammarino Marco Biomedica Veterinary Food Safety ‐ FOSA GR‐2013‐ 02358863 Prognostic Impact of Germline BRCA Mutations in Early‐ onset Triple‐negative Breast Cancer: A Multicenter, Population‐based Cancer Registry Study Emilia‐Romagna Musolino Antonino Clinico‐ Oncology 1 ‐ Basic assistenzial Translational e Cancer Genetics ‐ CG GR‐2013‐ 02358865 Development and analysis of new biomarkers for the assessment of disease activity and treatment response in patients with chronic inflammatory bowel diseases Toscana Faggioni Lorenzo Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Medical Imaging ‐ MEDI GR‐2013‐ 02358869 New approaches to enhance the immunogenicity and efficacy of DNA and avipox‐based recombinant vaccines for the therapy of HPV‐related tumors Lombardia Bissa Massimiliano Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII GR‐2013‐ 02358884 Neurological and biological aspects of ocular surface diseases and their impact on the quality of vision in relation to occupational tasks and environmental stress in the aging population NEUROLESI Rania Laura Clinico‐ Biology of Development assistenzial and Aging e Aging Systems and Geriatrics ‐ ASG GR‐2013‐ 02358888 Emotional Processing in Bipolar Disorder: an embodied perspective study FATEBENEFRATELLI Bulgari Viola Biomedica Adult Psychopathology and Disorders of Aging ‐ APDA GR‐2013‐ 02358896 Connect Our Children: Web Health Application for Monitoring Safety and Efficacy of Psychotropic Medications in Children andAdolescents Sicilia Lamberti Marco Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Biobehavioral and Behavioral Processes Classificazione 2° liv. Developmental Brain Disorders ‐ DBD Pagina 114 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02358898 Sicilia Cartilage regeneration by Mesenchymal Stem Cells (MSCs) cultured on a collagen scaffold (CCC) implantation and individual‐combined effects of a nutritional profile analogue to Mediterranean Diet, of TA‐ 65®, of recombinant lubricin and of physical activit Trovato Francesca Maria Biomedica GR‐2013‐ 02358899 Innovative use of satellite data for exposure assessment to Lazio evaluate the health effects of extreme temperatures and air pollution in Rome Stafoggia Massimo Clinico‐ Population Sciences and assistenzial Epidemiology e Social Sciences and Population Studies ‐ SSPS GR‐2013‐ 02358901 Mitochondrial dysfunction in Progressive Supranuclear Palsy: possible role of metal exposure MAGGIORE Viganò Mariele Biomedica Neural Oxidative Metabolism and Death ‐ NOMD GR‐2013‐ 02358902 BONE FRACTURE RISK IN GLUCOCORTICOID NEUROLESI INDUCED OSTEOPOROSIS IN MYASTHENIA GRAVIS. A POSSIBLE ANABOLIC EFFECT OF PYRIDOSTIGMINE ON BONE TISSUE Portaro Simona Clinico‐ Musculoskeletal, Oral and assistenzial Skin Sciences e Musculoskeletal, Oral and Skin Sciences Small Business ‐ SEMO GR‐2013‐ 02358906 Correlation between Epilepsy and Small Vessel Disease: a Calabria translational study Scicchitano Francesca Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Acute Neural Injury and Epilepsy ‐ ANIE GR‐2013‐ 02358912 HEAL2TOE: Towards a HEALthy locomotor development OSPEDALE BAMBINO in idiopathic TOE‐walking, kinematic and kinetic analysis GESU' and development of a novel orthosis TAVERNESE EMANUELA Biomedica Musculoskeletal, Oral and Skin Sciences Musculoskeletal, Oral and Skin Sciences Small Business ‐ SEMO GR‐2013‐ 02358930 Flexible endoscopic robotic device for paranasal diagnosis Toscana and treatment Dallan Iacopo Biomedica Bioengineering Sciences and Technologies Instrumentation and Systems Development ‐ ISD GR‐2013‐ 02358931 CSF B‐cells sorting: a new approach in identification of MS related antigens. Duranti Fabio Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN CARLO BESTA Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Musculoskeletal, Oral and Skin Sciences Molecular, Cellular, and Developmental Neuroscience Classificazione 2° liv. Musculoskeletal Tissue Engineering ‐ MTE Pagina 115 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02358946 Coronary artery disease progression in patients with acute coronary syndromes and diabetes mellitus GR‐2013‐ 02358949 Thromboelastometry (TEM) in acute coagulopathy of SAN RAFFAELE MILANO trauma (ACT): development of an innovative TEM driven transfusion support protocol and search for new prognostic markers of ACT. GR‐2013‐ 02358950 Molecular characterization of glioblastoma multiforme progression and recurrence: a new in vivo model for patients stratification and treatments tailoring GR‐2013‐ 02358953 AREA P.I. Stefanini Giulio Giuseppe Clinico‐ Tassara Lombardia DIVERSITY MANAGEMENT STRATEGIES IMPACT ON WORK‐RELATED STRESS AND PATIENT SATISFACTION GR‐2013‐ 02358955 Classificazione 1 Liv. Classificazione 2° liv. Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS Michela Giulia Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Surgery, Anesthesiology, and Trauma ‐ SAT Giussani Carlo Giorgio Biomedica Basic Mechanisms of Cancer Therapeutics ‐ BMCT Emilia‐Romagna Rodeschini Giulia Clinico‐ Risk, Prevention and assistenzial Health Behavior e Psychosocial Development, Risk, and Prevention ‐ PDRP Mutimodal analysis in Fronto‐temporal Dementia SAN RAFFAELE PISANA MIRAGLIA FRANCESCA Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02358956 Targeted genome editing of the CD40LG gene for the treatment of X‐linked hyper‐IgM immunodeficiency SAN RAFFAELE MILANO Genovese Pietro Biomedica Genes, Genomes and Genetics Gene Therapy and Inborn Errors ‐ GTIE Special Emphasis Panel GR‐2013‐ 02358959 7‐Tesla MR investigation of motor cortex in Amyotrophic Toscana Lateral Sclerosis: functional and structural hallmarks for diagnosis and prognosis at a single‐subject level Pesaresi Ilaria Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02358961 ENVIRONMENTAL IMPACT ASSESSMENT ON TESTICULAR CANCER AND MALE REPRODUCTIVE FUNCTION Crispo Anna Biomedica Cancer Molecular Pathobiology ‐ CAMP HUMANITAS PASCALE Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Oncology 2 ‐ Translational Clinical Oncology 1 ‐ Basic Translational Pagina 116 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO GR‐2013‐ 02358962 Novel serological tests for diagnosis and follow‐up of human cystic echinococcosis GR‐2013‐ 02358966 DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. MARICONTI MARA Biomedica Infectious Diseases and Microbiology Infectious Diseases and Microbiology Fellowship ‐ F13 Cardiac sympathetic nervous system: genetics, functional MAUGERI anatomy and risk of sudden death. Novelli Valeria Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD GR‐2013‐ 02358968 Mitochondrial dysfunction as a common pathogenic pathway in neurodegeneration STELLA MARIS Meschini Maria Chiara Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD GR‐2013‐ 02358974 Combination therapy with Mirabegron and Tadalafil for the treatment of Neurogenic Overactive Bladder and Sexual Dysfunction in Multiple Sclerosis male patients. Sicilia favilla vincenzo Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Urologic and Kidney Development and Genitourinary Diseases ‐ UKGD GR‐2013‐ 02358975 Mediterranean Diet, Cellular Markers of Low Grade Inflammation and Risk of Cerebrovascular and Cardiovascular Events. NEUROMED Costanzo Simona Biomedica Population Sciences and Epidemiology Cardiovascular and Sleep Epidemiology ‐ CASE GR‐2013‐ 02358978 Optimization and pilot clinical trial of a three‐ dimensional electromagnetic endovascular navigator Toscana Condino Sara Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Electromagnetic Devices Special Emphasis Panel ‐ SEED GR‐2013‐ 02358980 CSF peptide profile in Mild Cognitive Impairment with and with no AD pathology FATEBENEFRATELLI Marizzoni Moira Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02358983 New strategies for diagnostic, therapeutic and clinical care in Metabolism disorders and cardiovascular disease Calabria Succurro Elena Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO GR‐2013‐ 02358986 Molecular profile and pathway analysis of oropharyngeal squamous cell carcinoma: an ex vivo 3D multi‐layer cell culture model to identify biomarkers for patient‐tailored therapies PASCALE Annunziata Clorinda Biomedica Modeling and Analysis of Biological Systems ‐ MABS SAN MATTEO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Bioengineering Sciences and Technologies Pagina 117 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02358995 A new insight into pediatric leukemia: Che‐1 involvement OSPEDALE BAMBINO in oncogenic c‐Myc signaling GESU' GR‐2013‐ 02358997 In vitro and in vivo studies for the application of Boron Neutron Capture Therapy in patients affected by malignant mesothelioma GR‐2013‐ 02359000 T lymphocyte recruitment and severe chronic epilepsy: evidence from human patients and experimental model and possible neuroprotective and antiepileptic effect of therapies preventing glia activation/neuroinflammation and T cell infiltration GR‐2013‐ 02359001 Evaluation of gold nanoparticles as radioenhancing agent CARLO BESTA in the radiation therapy treatment of gliobastoma multiforme: an in vitro and in vivo study for a new standard of care GR‐2013‐ 02359010 MicroRNA as novel prognostic and pharmacogenomic biomarkers in premature infants with patent ductus arteriosus treated with ibuprofen GR‐2013‐ 02359021 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Folgiero Valentina Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC SAN MATTEO Protti Nicoletta Biomedica Oncology 2 ‐ Translational Clinical Radiation Therapeutics and Biology ‐ RTB CARLO BESTA Finardi Adele Biomedica Brain Disorders and Clinical Neuroscience Acute Neural Injury and Epilepsy ‐ ANIE De Martin Elena Biomedica Oncology 2 ‐ Translational Clinical Radiation Therapeutics and Biology ‐ RTB BURLO GAROFALO De Cunto Angela Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD Multimodal approach to the non‐invasive monitoring of patients with disorders of consciousness Toscana Bandini Andrea Biomedica Bioengineering Sciences and Technologies Instrumentation and Systems Development ‐ ISD GR‐2013‐ 02359022 The psychopathological and cognitive pattern of rare brain diseases. CARLO BESTA Manfredi Valentina Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02359023 Study of representation and functional activity of CD4+ T SAN RAFFAELE MILANO cell subsets in multiple myeloma: association with disease status, prognosis and response to therapy Di Lullo Giulia Biomedica Transplantation, Tolerance and Tumor Immunology ‐ TTT Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Immunology Pagina 118 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02359029 FATEBENEFRATELLI Effects of neuromodulation (tDCS) for the treatment of Cocaine Addiction. Reduction of Cortical mechanisms of Reward Bias and Inter‐Hemispheric unbalance measured by fNIRS and EEG. Finocchiaro Roberta Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Neural Basis of Psychopathology, Addictions and Sleep Disorders ‐ NPAS GR‐2013‐ 02359031 Modeling human clonal dynamics of hematopoietic system reconstitution of gene therapy patients through vector integration sites for predicting system response to clinical injuries Calabria Andrea Biomedica Healthcare Delivery and Methodologies Biostatistical Methods and Research Design ‐ BMRD GR‐2013‐ 02359032 Targeting beta‐Amyloid Peptide asseMblies in Alzheimer FATEBENEFRATELLI Disease: a multidisciplinary approach (TAP‐ MAD) Casalini Stefano Biomedica Bioengineering Sciences and Technologies Biomaterials and Biointerfaces ‐ BMBI GR‐2013‐ 02359041 Evaluation of innovative molecular and proteomic assays for rapid detection of carbapenemase production among gram negative bacteria directly from blood cultures SPALLANZANI Di Bella Stefano Biomedica Infectious Diseases and Microbiology Clinical Research and Field Studies of Infectious Diseases ‐ CRFS GR‐2013‐ 02359044 Glycosphingolipid synthetic pathway as valuable therapeutic option for the treatment of GOLPH3‐ dependent NSCLC. PASCALE Leone Alessandra Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC GR‐2013‐ 02359045 HUMANITAS Predictive role of tumor hypoxia imaging, circulating microRNAs and immune‐related markers in patients with locally advanced non‐small cell lung cancer (NSCLC). Lopci Egesta Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02359053 Cell autonomous and cell non‐autonomous roles of p27kip1 in HER2‐driven breast cancer onset and progression C.R.O. AVIANO Segatto Ilenia Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC GR‐2013‐ 02359054 Patients with oligometastatic prostate cancer: role of stereotacic radiotherapy and exosomes. Possible impact on cost/benefits and clinical outcome Toscana Pasqualetti Francesco Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e SAN RAFFAELE MILANO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Radiation Therapeutics and Biology ‐ RTB Pagina 119 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02359056 Friuli‐Venezia Giulia Lipostructure in breast reconstruction: comparative analysis of the standard‐ and four commercially available Cell‐Assisted Lipotransfer techniques in terms of ability to enrich fat grafts in stem cells, clinical outcome and prevent capsular contracture. GR‐2013‐ 02359057 Clinical evaluation and health technology assessment of an innovative approach to spinal fusion surgery: the patient specific templates. GR‐2013‐ 02359058 A protein profiles study to identify ideal early biomarkers NEUROLESI for High‐Risk Human Papillomaviruses infection and cancer progression diagnosis GR‐2013‐ 02359060 Multimodal neurophysiological approach for the diagnostic and prognostic assessment of patients with disorders of consciousness GR‐2013‐ 02359062 Disclosing Cerebral Cavernous Malformations pathogenesis: from genotype‐ phenotype correlation to characterization of cross‐talk in neurovascular unit GR‐2013‐ 02359064 The Biological Resource & Expert Centre of the IRCCS Istituto Scientifico Scientific Institute of Romagna for the Study and Romagnolo Treatment of Cancer (BRC‐IRST): a hub and spoke model of biobank network GR‐2013‐ 02359069 Magnetic Resonance Spectroscopy as a marker of response to dopaminergic treatment in Parkinson's Disease GR‐2013‐ 02359071 VITAMIN E SUPPLEMENTATION FOR ANTIVIRAL TREATMENT OF CHRONIC HEPATITIS B. AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Lara Lazzaro Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences ‐ BTSS Parchi Paolo Domenico Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma ‐ SAT Bertuccio Maria Paola Biomedica Infectious Diseases and Microbiology Virology A and B Study Sections ‐ VIRA and VIRB Emilia‐Romagna Guaraldi Pietro Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN NEUROLESI Scimone Concetta Biomedica Brain Disorders and Clinical Neuroscience Brain Injury and Neurovascular Pathologies ‐ BINP Turri Valentina Biomedica Population Sciences and Epidemiology Epidemiology of Cancer ‐ EPIC NEUROLESI CIURLEO ROSELLA Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN Emilia‐Romagna Conti Fabio Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS Toscana Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 120 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02359079 Immobilization System Evaluation for Robot Patient Positioning System (RPPS) CROB Caivano Rocchina Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Radiation Therapeutics and Biology ‐ RTB GR‐2013‐ 02359081 The nuclear factor HMGA1: a novel gene for early diagnosis and prognosis of type 2 diabetes mellitus Calabria IIRITANO STEFANIA Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Molecular and Cellular Endocrinology ‐ MCE GR‐2013‐ 02359083 CYCLING OF INTENSIFIED ANTIRTEROVIRALS IN PATIENTS WITH HIV INFECTION TREATED SINCE EARLY/ACUTE INFECTION (CYCLING Study) SPALLANZANI Pinnetti Carmela Clinico‐ AIDS and Related Research assistenzial e AIDS Clinical Studies and Epidemiology ‐ ACE GR‐2013‐ 02359092 Testing the concept of Acute Coronary Syndrome in Patients Without Angiographic Evidence of Obstructive Coronary Plaques: A Cross‐Sectional Diagnostic Study SAN MATTEO LEONARDI SERGIO Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS GR‐2013‐ 02359099 A Randomized, Placebo‐controlled, Double Blind "Futility Design" Clinical Trial of R Treatment of Amyotrophic Lateral Sclerosis. Emilia‐Romagna MANDRIOLI JESSICA Biomedica Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02359104 The nerves PISTA project: Nerves Physiological Imaging for Safe Treatment Approach. Role of combined ultrasonographic imaging and neurophysiological investigation for treatment of peripheral nerve pathologies. Sicilia Gagliardo Andrea Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Small Business Bioengineering, Surgical Sciences, and Technology ‐ SBTS (SBIR/STTR) GR‐2013‐ 02359114 Monitoring and managing metabolic disturbances in Emilia‐Romagna people taking antipsychotic drugs: a cluster randomized trial of an intervention combining evidence‐based quality improvement and a computer based intervention. Tedeschini Enrico Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD GR‐2013‐ 02359115 Mobile genetic elements: new approaches for Abruzzo epidemiological studies on antibiotic resistance mechanisms in Gram‐negative clinical and environmental isolates. Bellio Pierangelo Biomedica Drug Discovery and Mechanisms of Antimicrobial Resistance ‐ DDR Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Brain Disorders and Clinical Neuroscience Infectious Diseases and Microbiology Classificazione 2° liv. Pagina 121 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02359118 A MultidisciplinAry iNtervention of DOmiciliary asSIstance for demented elderly and their caregiver: the effects on quality of life and functional status Acronym: AMANDOSI I.N.R.C.A. Giuli Cinzia Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD GR‐2013‐ 02359125 Combination of enzyme replacement therapy and pharmacological chaperones for the treatment of Pompe disease. Campania Porto Caterina Biomedica Therapeutic Approaches to Genetic Diseases ‐ TAG GR‐2013‐ 02359126 Mitochondrial diseases in Tuscany: a strategic plan to implement disease awareness and management STELLA MARIS Rubegni Anna Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02359128 POST RESECTIONAL BRONCHO‐PLEURAL FISTULA CLOSURE BY AUTOLOGOUS BONE ¿ MARROW DERIVED MESENCHYMAL STEM CELL BRONCHOSCOPIC TRANSPLANTATION:AN EXPERIMENTAL MODEL ON GOATS I.E.O. Petrella Francesco Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences ‐ BTSS GR‐2013‐ 02359132 Meningioma radiosurgery: hormonal receptors modulation, related pathways and their correlation with radiosensitivity. In vitro and in vivo study. CARLO BESTA Pinzi Valentina Biomedica Oncology 2 ‐ Translational Clinical Radiation Therapeutics and Biology ‐ RTB GR‐2013‐ 02359134 Evaluation of the prothrombotic and inflammation state in patients with severe aortic stenosis before and after implantation of two different prosthetic valves: sutured versus sutureless bioprostheses. HUMANITAS Miceli Antonio Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma ‐ SAT GR‐2013‐ 02359137 Trend of HPV‐associated oropharyngeal cancer in Italy from 1990 to 2012 I. O. V. Baboci Lorena Clinico‐ Population Sciences and assistenzial Epidemiology e Epidemiology of Cancer ‐ EPIC GR‐2013‐ 02359146 The role of Adenovirus 36 in the Obesity Istituto Superiore di Sanita' PONTERIO ELEONORA Biomedica Clinical and Integrative Diabetes and Obesity ‐ CIDO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Genes, Genomes and Genetics Endocrinology, Metabolism, Nutrition and Reproductive Sciences Pagina 122 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02359154 Thalamo‐cortical dysfunction as a marker of Lewy Bodies S.CAMILLO Disease in the early stage Delli Pizzi Stefano Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02359156 Development of a new clinical evaluation tool to check spinal functions (STACMOQ ‐ STAbility Control and MOvement Quality) in neurological diseases and aging based on movement analysis DON GNOCCHI Pirali Caterina Biomedica Musculoskeletal, Oral and Skin Sciences Musculoskeletal Rehabilitation Sciences ‐ MRS GR‐2013‐ 02359157 Unravelling the Genetic Defects in Progressive Familial Intrahepatic Cholestasis (PFIC): a Next Generation Sequencing Approach Emilia‐Romagna Vitale Giovanni Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD GR‐2013‐ 02359160 Tailored cathodal tDCS in drug‐resistant epileptic patients OSPEDALE BAMBINO GESU' Assenza Giovanni Biomedica Brain Disorders and Clinical Neuroscience Acute Neural Injury and Epilepsy ‐ ANIE GR‐2013‐ 02359163 Crizotinib Targeted Multistage Vector for treatment of childhood malignant solid tumor (Neuroblastoma). Veneto Molinaro Roberto Biomedica Bioengineering Sciences and Technologies Gene and Drug Delivery Systems ‐ GDD GR‐2013‐ 02359168 Role of Neuregulin 1 signalling in the modulation of mesencephalic dopaminergic neurons activity: implications in the pathogenesis and therapy of schizophrenia SANTA LUCIA Ledonne Ada Biomedica Brain Disorders and Clinical Neuroscience Pathophysiological Basis of Mental Disorders and Addictions ‐ PMDA GR‐2013‐ 02359170 The "Poli‐Framingham Study": a cohort study on cardiovascular risk, lifestyle and cognitive function of midlife employees of the Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico MAGGIORE Marcucci Maura Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02359177 Device for evaluating laryngeal cough reflex in health subjects and amyotrophic lateral sclerosis (ALS) patients. MAGGIORE frasca vittorio Biomedica Clinical Neuroscience and Neurodegeneration ‐ CNN Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Brain Disorders and Clinical Neuroscience Classificazione 2° liv. Pagina 123 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02359180 Bio Engineering in Proctological Surgery: autologous graft surgery. Toscana Giani Iacopo Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Clinical, Integrative and Molecular Gastroenterology ‐ CIMG GR‐2013‐ 02359183 Muscle vibration and spasticity in stroke: a combined neurophysiological and neuroradiological approach. NEUROLESI Naro Antonino Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Brain Injury and Neurovascular Pathologies ‐ BINP GR‐2013‐ 02359185 CD45RA‐depleted donor lymphocyte infusions for the HUMANITAS prevention of infections in patients affected by hematological malignancies after haploidentical stem cell transplantation and post‐transplant cyclophosphamide CROCCHIOLO ROBERTO Biomedica Immunology Transplantation, Tolerance and Tumor Immunology ‐ TTT GR‐2013‐ 02359187 MAUGERI The equilibrium in the frontal plane during stance and locomotion along curved trajectories: basic mechanisms, rationale for rehabilitation and validation of training protocols in patients with selected diseases of the central nervous system. Godi Marco Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02359191 In vitro and in vivo models to study anti‐ transglutaminase antibodies dependent reproductive changes Quaglia Sara Biomedica Digestive, Kidney and Urological Systems Gastrointestinal Mucosal Pathobiology ‐ GMPB GR‐2013‐ 02359194 MONDINO Exploring brain networks and structural connectivity architecture as neural correlate of cognitive recovery after stroke Zucchella Chiara Clinico‐ Integrative, Functional, assistenzial and Cognitive Neuroscience e Cognitive Neuroscience ‐ COG GR‐2013‐ 02359195 NEUROMED A‐synuclein deposition, cross‐modal cortical plasticity and motor symptoms detected by whole body biosensors in Parkinson's Disease: a new translational approach Suppa Antonio Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02359205 Breath Biomarkers and Acute respiratory distress Syndrome Puglia Mirabella Lucia Biomedica Cardiovascular and Respiratory Sciences Lung Injury, Repair, and Remodeling ‐ LIRR GR‐2013‐ 02359206 Analysis of toxicity of anti‐angiogenic therapy in elderly subjects and in vitro models of endothelial cells aging. ARCISPEDALE Chiappelli Martina Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME BURLO GAROFALO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 124 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02359211 PSY‐Sport Rehab: Investigation of the role of Physical Activity and Psycho‐education on immune function and quality of life in cancer survivors ONCOLOGICO DI BARI Romito Francesca Clinico‐ Biobehavioral and assistenzial Behavioral Processes e Biobehavioral Mechanisms of Emotion, Stress and Health ‐ MESH GR‐2013‐ 02359212 Chimeric antigen receptor‐redirected T cells targeting CD19 antigen: first‐in‐human Italian trial for children with chemotherapy‐refractory Acute Lymphoblastic Leukemia. OSPEDALE BAMBINO GESU' Quintarelli Concetta Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Immunopathology and Immunotherapy ‐ CII GR‐2013‐ 02359217 FOXO3a‐FOXM1 axis in pediatric T‐cell acute lymphoblastic leukemia (T‐ALL): involvement in tumor progression, epigenetic reprogramming and drug resistance. Veneto Bortolozzi Roberta Biomedica Interdisciplinary Molecular Sciences and Training Fellowship: Oncological Sciences ‐ F09 GR‐2013‐ 02359221 Innovative strategies to boost thymopoiesis after cyto‐ ablative and immunosuppressive treatment SAN RAFFAELE MILANO BORTOLOMA ILEANA Biomedica Immunology Transplantation, Tolerance and Tumor Immunology ‐ TTT GR‐2013‐ 02359223 Familial Prion Polyneuropathy (FPP): Prevalence Of Prion Protein Mutation In Polyneuropathy Mimicking Familial Amyloid Polyneuropathy in Emilia‐Romagna Region Emilia‐Romagna D'Angelo Roberto Clinico‐ Genes, Genomes and assistenzial Genetics e Genetics of Health and Disease ‐ GHD GR‐2013‐ 02359224 Genetic epidemiology and molecular characterization of phenotypes associated with D4Z4 macrosatellite repeat variations: novel diagnostic tools for myopathies. Toscana Ricci Giulia Clinico‐ Genes, Genomes and assistenzial Genetics e Genetics of Health and Disease ‐ GHD GR‐2013‐ 02359238 Noninvasive assessment of spleen stiffness by shear wave SAN MATTEO elastography in cirrhotic patients as predictive sign of portal hypertension and esophageal varices Lissandrin Raffaella Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Clinical, Integrative and Molecular Gastroenterology ‐ CIMG GR‐2013‐ 02359243 Risk assessment of Crimean‐Congo hemorrhagic fever in North‐East Italy Mughini Gras Lapo Biomedica Animal Health ‐ ANHE IZSVE Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Veterinary Classificazione 2° liv. Pagina 125 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02359249 Functional Magnetic Resonance Imaging and olfactory receptors gene variants in the evaluation of smell perception in severe obese patients. SDN Labruna Giuseppe Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Medical Imaging ‐ MEDI GR‐2013‐ 02359252 The role of the cortical excitability in the modulation of neuroplasticity in neurological diseases FATEBENEFRATELLI Fertonani Anna Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02359253 Neuroimaging correlates of blinking abnormalities in patients with Progressive Supranuclear Palsy. NEUROMED Bologna Matteo Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02359257 Molecular mechanisms underling oxidative stress in CDKL5 disorders Toscana Pecorelli Alessandra Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD GR‐2013‐ 02359260 New strategies for targeted therapeutic intervention of obesity: exploiting fat "browning" by Mineralocorticoid Receptor and p66Shc interaction SAN RAFFAELE PISANA Marzolla Vincenzo Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular Aspects of Diabetes and Obesity ‐ CADO GR‐2013‐ 02359264 The PRIORITY Study ‐ PRedictIng long term Outcomes afteR Isolated coronary arTery bypass surgerY Piemonte BARILI FABIO Clinico‐ Healthcare Delivery and assistenzial Methodologies e GR‐2013‐ 02359265 Kinematic and electromyographic assisted ankle spasticity treatment. Comparative study to address treatment efficacy. SANTA LUCIA Tamburella Federica Clinico‐ Emerging Technologies and Sensory, Motor and assistenzial Training in Neurosciences Cognitive e Neuroscience Fellowship ‐ F02B GR‐2013‐ 02359267 Anticoagulation therapy with warfarin in the uremic patients: traditional and new markers of vascular calcification Emilia‐Romagna salomone luisa Clinico‐ Vascular and Hematology assistenzial e Hemostasis and Thrombosis ‐ HT GR‐2013‐ 02359268 New technological approaches for the improvement of the safety and quality of Italian fishery products (SAFEfish) IZSPLV Bianchi Daniela Manila Biomedica Food Safety ‐ FOSA Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Veterinary Classificazione 2° liv. Health Services Organization and Delivery ‐ HSOD Pagina 126 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO GR‐2013‐ 02359270 Assessment of tumor heterogeneity of colorectal carcinoma through analysis of liquid biopsies GR‐2013‐ 02359281 DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Rachiglio Anna Maria Biomedica SDN SLEEP DISORDERED BREATHING AND CARDIAC SYMPATHETIC INNERVATION IN PATIENTS AFFECTED BY HEART FAILURE: PATHOPHYSIOLOGICAL MECHANISMS, PREVALENCE AND PROGNOSTIC IMPLICATIONS. Marciano Caterina Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS GR‐2013‐ 02359291 Deciphering the mechanisms of resistance to lapatinib in Campania breast cancer Giuliano Mario Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB GR‐2013‐ 02359293 Perioperative Administration of Dexamethasone and Infection Zambon Massimo Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma ‐ SAT GR‐2013‐ 02359295 Self‐awareness in preclinical Alzheimer¿s Disease: neural Emilia‐Romagna correlates and prognostic implications Tondelli Manuela Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02359296 The link between HER2 addiction and immune infiltration as determinant of trastuzumab efficacy ISTITUTO TUMORI MILANO Triulzi Tiziana Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII GR‐2013‐ 02359299 Childhood Cancer Registry of Puglia ONCOLOGICO DI BARI CANNONE GRAZIA ANTONELLA Clinico‐ Population Sciences and assistenzial Epidemiology e GR‐2013‐ 02359300 SPRINT a post Stroke inPatient Rehabilitation in a INtelligent environmenT I.N.R.C.A. Felici Elisa Clinico‐ Emerging Technologies and Sensory, Motor and assistenzial Training in Neurosciences Cognitive e Neuroscience Fellowship ‐ F02B GR‐2013‐ 02359301 Methylene blue in patients with septic shock. A multicenter randomized clinical trial. SAN RAFFAELE MILANO Pasin Laura Biomedica PASCALE SAN RAFFAELE MILANO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Oncology 2 ‐ Translational Clinical Cardiovascular and Respiratory Sciences Cancer Biomarkers ‐ CBSS Epidemiology of Cancer ‐ EPIC Clinical and Integrative Cardiovascular Sciences ‐ CICS Pagina 127 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02359303 HOXB7 master role in the molecular circuitry associated with acquired resistance to anti‐estrogen treatments in human breast cancer: potential predictive and therapeutic values Istituto Superiore di Sanita' Errico Maria Cristina Biomedica GR‐2013‐ 02359305 End‐Of‐Life Care Pathways In General Hospitals Emilia‐Romagna Carandina Ilaria Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD GR‐2013‐ 02359313 TIME RELIABILITY OF LASER'S DEVICES IN DERMATOLOGY SAN GALLICANO Mariano Maria Biomedica Musculoskeletal, Oral and Skin Sciences Musculoskeletal, Oral and Skin Sciences Small Business ‐ SEMO GR‐2013‐ 02359315 TOWARD ADAPTIVE DEEP BRAIN STIMULATION FOR MAGGIORE GAIT DISTURBANCES IN PARKINSON'S DISEASE. Rosa Manuela Biomedica Bioengineering Sciences and Technologies Instrumentation and Systems Development ‐ ISD GR‐2013‐ 02359320 Use of attenuated Salmonella enterica serovar Typhimurium as anticancer treatment Istituto Superiore di Sanita' Chirullo Barbara Biomedica Oncology 2 ‐ Translational Clinical Developmental Therapeutics ‐ DT GR‐2013‐ 02359331 Role of the melanoma stem cells‐tumor microenvironment interplay in melanoma invasion and metastasis ARCISPEDALE Dallaglio Katiuscia Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME GR‐2013‐ 02359332 NEUROPILIN‐1, PLACENTA GROWTH FACTOR AND PLATELET DERIVED GROWTH FACTOR‐C AS THERAPEUTIC TARGETS IN HUMAN MELANOMA ISTITUTO DERMOPATICO DELL'IMMACOLATA Ruffini Federica Biomedica Oncology 1 ‐ Basic Translational Tumor Progression and Metastasis ‐ TPM2 GR‐2013‐ 02359341 The predictive values of brain connectivity for the diagnosis of disorder of consciousness using a multimodal magnetic resonance imaging protocol NEUROLESI Marino Silvia Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Acute Neural Injury and Epilepsy ‐ ANIE GR‐2013‐ 02359352 miR‐155 as an epigenetic regulator of B cell lineage activity in Rheumatoid Arthritis Lazio Alivernini Stefano Biomedica Hypersensitivity, Autoimmune, and Immune Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Oncology 1 ‐ Basic Translational Immunology Tumor Cell Biology ‐ TCB Pagina 128 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02359355 Augmented Reality in Head and Neck Oncology: development of a system to improve surgical resection, reconstruction and interdisciplinary interface between surgery, pathology and radiotherapy. GR‐2013‐ 02359357 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Copelli Chiara Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Bioengineering, Technology, and Surgical Sciences ‐ BTSS SAN GALLICANO NON INVASIVE "IN VIVO" DIAGNOSIS AND THERAPEUTICAL FOLLOW‐UP OF CICATRICIAL AND NON CICATRICIAL ALOPECIAS AGOZZINO MARINA Biomedica Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ‐ ACTS GR‐2013‐ 02359361 Emilia‐Romagna Inflammasome activity and modulation in different Multiple Sclerosis forms and as a predictor of response to interferon‐beta therapy Ferraro Diana Biomedica Immunology Innate Immunity And Inflammation ‐ III GR‐2013‐ 02359362 Familial Hypercholesterolemia: study of miRNome and proteome to identify new molecular pathways SDN Di Taranto Maria Donata Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD GR‐2013‐ 02359372 Enhanced surveillance and clinical impact of hospital‐ acquired viral gastroenteritis in children hospitals OSPEDALE BAMBINO GESU' Valentini Diletta Biomedica Infectious Diseases and Microbiology Infectious Diseases and Microbiology Fellowship ‐ F13 GR‐2013‐ 02359374 BURLO GAROFALO Exploring Genetic Connections of Dysregulated Insulin Secretion Between Congenital Hyperinsulinism and Insulinomas for the Identification of New Causative Genes ATHANASAKI EMMANOUIL S Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD GR‐2013‐ 02359376 Resting state networks and cognitive functioning in epileptic patients NEUROLESI Nunnari Domenica Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Acute Neural Injury and Epilepsy ‐ ANIE GR‐2013‐ 02359378 Sentinel lymph node biopsy in breast cancer: Impact of biological tumor features on lymphatic drainage pattern and on the choice of the lymphoscintigraphy execution modality. ARCISPEDALE falco giuseppe Clinico‐ Interdisciplinary Molecular assistenzial Sciences and Training e Fellowship: Oncological Sciences ‐ F09 GR‐2013‐ 02359382 STEM CELLS DERIVED FROM EXTRA‐EMBRYONIC TISSUES FOR TENDON REGENERATION Abruzzo Abate Michele Biomedica Musculoskeletal Tissue Engineering ‐ MTE CASA SOLLIEVO SOFFERENZA Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Musculoskeletal, Oral and Skin Sciences Pagina 129 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02359383 Targeting the lysosome to modulate mTORC1 function and treat obesity‐associated metabolic disorders GR‐2013‐ 02359386 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. settembre Carmine Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular Aspects of Diabetes and Obesity ‐ CADO Transcatheter arterial chemoembolization using REGINA ELENA Fotemustine Mixed with Degradable Starch Microspheres (DMS) plus intravenous ipilimumab for Liver Metastases from uveal melanoma nuzzo carmen Biomedica Oncology 2 ‐ Translational Clinical Clinical Oncology ‐ CONC GR‐2013‐ 02359387 Biomechanical study of the postural balance: search for reliable biomarkers to develop a micro‐electromachinal device based on haptic feedback as a system to prevent falls SDN Agosti Valeria Biomedica Emerging Technologies and Neurotechnology ‐ Training in Neurosciences NT GR‐2013‐ 02359392 New treatment perspectives in Eating Disorders: the efficacy of non‐invasive brain‐directed treatment OSPEDALE BAMBINO GESU' Costanzo Floriana Clinico‐ Emerging Technologies and Brain Disorders and assistenzial Training in Neurosciences Related e Neurosciences Fellowship ‐ F01 GR‐2013‐ 02359400 Surveillance of Mycobacterium Avium subspecies Paratuberculosis infection through the analysis of microbiome and environmental factors. IZSSI FALDUTO MARIA Biomedica Infectious Diseases and Microbiology Host Interactions with Bacterial Pathogens ‐ HIBP GR‐2013‐ 02359401 Identification of leukaemia cell ligands for activating human NK receptors OSPEDALE BAMBINO GESU' Romania Paolo Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII GR‐2013‐ 02359405 Use of early non‐invasive ventilation to reduce the need for intensive care unit. A multricentric randomized trial. SAN RAFFAELE MILANO Monti Giacomo Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR GR‐2013‐ 02359407 Sorting out West Nile virus Pandora's box: identifying virulence determinants to understand host anti‐viral immune responses and predict pathogenesis Istituto Superiore di Sanita' Capocefalo Antonio Biomedica Virology A and B Study Sections ‐ VIRA and VIRB SAN RAFFAELE MILANO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Infectious Diseases and Microbiology Pagina 130 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02359410 Multisensory integration and immune system: new perspectives for obesity. AUXOLOGICO Scarpina Federica Clinico‐ Integrative, Functional, assistenzial and Cognitive Neuroscience e Neuroendocrinology, Neuroimmunology and Behavior ‐ NNB GR‐2013‐ 02359418 MODELING REDOX BALANCE IN HEPATIC PROGENITOR CELLS: IMPACT ON CARCINOGENESIS DURING CHRONIC LIVER DISEASES Puglia Bellanti Francesco Biomedica Oncology 1 ‐ Basic Translational Cancer Etiology ‐ CE GR‐2013‐ 02359430 Study of microRNA signatures and functions in frontotemporal dementia FATEBENEFRATELLI Maffioletti Elisabetta Biomedica Genes, Genomes and Genetics Molecular Genetics ‐ MGA GR‐2013‐ 02359431 Connectivity changes as biomarker of neurodegeneration SDN in Alzheimer's disease and frontotemporal dementia: a multimodal neuroimaging approach. Rombetto Sara Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02359439 pharmacogenetic bases of the safety and efficacy of novel SAN RAFFAELE MILANO adjuvants in vaccines: a methodological approach Rigamonti Elena Biomedica Immunology Vaccines Against Microbial Diseases ‐ VMD GR‐2013‐ 02359455 Umbria Frame‐work for Anticoagulation Surveillance: long‐term safety and effectiveness of new oral anticoagulants in real‐life for prevention of cardioembolism in non valvular atrial fibrillation and for the treatment of venous thromboembolism. The UFAS s Umbria Vedovati Maria Cristina Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD GR‐2013‐ 02359457 Characterization of microRNA (MiRNAs) alterations in neuronal‐like models of neurodegenerative disorders SANTA LUCIA Croce Nicoletta Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND GR‐2013‐ 02359458 The neural underpinnings of emotional impulsivity as a common biomarker of affective disorders: an integrated multimodal imaging study. MEDEA Maggioni Eleonora Biomedica Brain Disorders and Clinical Neuroscience Pathophysiological Basis of Mental Disorders and Addictions ‐ PMDA GR‐2013‐ 02359460 Thyroid cancer risk and gene susceptibility in Mt. Etna volcanic area: a case‐control study. Sicilia Malandrino Pasqualino Clinico‐ Oncology 1 ‐ Basic assistenzial Translational e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Cancer Etiology ‐ CE Pagina 131 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02359464 Targeted personalized therapy of Acute Myeloid Leukemia: Next Generation Sequencing and metabolomics‐based approaches GR‐2013‐ 02359469 The role of cytomegalovirus and sphingosine‐1‐phosphate MAGGIORE cross‐talk on stemness and aggressiveness of glioblastoma multiforme: an integrated molecular and bioinformatic approach to derive molecular mechanisms and therapeutic implications GR‐2013‐ 02359472 A novel in vivo hydroxyapatite functionalized scaffold (SCID‐synth‐bone) as a preclinical platform for anti Myeloma agents development GR‐2013‐ 02359477 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. papayannids cristina Biomedica Oncology 1 ‐ Basic Translational Cancer Genetics ‐ CG marfia giovanni Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP Calimeri Teresa Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME Q fever in Italy: an integrated surveillance system based Emilia‐Romagna on epidemiological and genotyping studies in human and animal populations Pierro Anna Biomedica Infectious Diseases and Microbiology Clinical Research and Field Studies of Infectious Diseases ‐ CRFS GR‐2013‐ 02359479 Olfactory dysfunction in Multiple Sclerosis detected by using Olfactory Event Related Potentials: early marker of neuroinflammation‐neurodegeneration or disease progression? NEUROLESI Caminiti Fabrizia Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02359487 Adrenomedullin and autoimmune hepatitis: new insight in thymic mechanisms Veneto De Martin Sara Biomedica Immunology Hypersensitivity, Autoimmune, and Immune GR‐2013‐ 02359489 Long‐term Recreational football training as useful tool to SDN improve health‐related fitness in T2DM subjects : effects on muscle oxidative metabolism, CVD risk, QoL and pharmacological treatment. Martone Domenico Biomedica Risk, Prevention and Health Behavior SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan ‐ TPM1 GR‐2013‐ 02359493 MAGGIORE Identification of potential glioblastoma‐associated autoantibodies: definition of new circulating biomarkers and development of anti‐angiogenic multitarget therapies navone stefania Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME Emilia‐Romagna Calabria Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 132 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02359504 A randomized control trial pilot study on effectiveness of S.CAMILLO a combination Between assistive technology, neurostimUlation and behavIouraL strategy in in persons with Disorders Of consciousNess: BUILD‐ON project GR‐2013‐ 02359506 STEREOTACTIC HYPOFRACTIONATED RADIOTHERAPY (SBRT) WITH CYBERKNIFE SYSTEM FOR LOW‐INTERMEDIATE RISK PROSTATE CANCER GR‐2013‐ 02359510 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Cavinato Marianna Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Acute Neural Injury and Epilepsy ‐ ANIE Borzillo Valentina Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Oncology 2 ‐ Translational Clinical Small Business [SBIR/STTR] Radiation Therapy and Biology ‐SETA] Development of a statistical procedure to facilitate the ISTITUTO TUMORI use of circulating microRNA biomarkers in clinical MILANO practice by adjusting the classification accuracy to plasma haemolysis levels Pizzamiglio Sara Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02359511 Liquid biopsies for monitoring the activity of anti‐EGFR PASCALE therapies in metastatic colorectal carcinoma patients with liver‐limited disease Ottaiano Alessandro Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS GR‐2013‐ 02359512 Discovery of prognostic vs. predictive biomarkers in patients with advanced, BRAF‐mutated colorectal cancer receiving standard chemotherapy vs. targeted treatment ISTITUTO TUMORI MILANO Pietrantonio Filippo Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS GR‐2013‐ 02359513 Bioremediation as a novel tool for feed and food safety. IZSLER Lorenzi Valentina Biomedica Veterinary Food Safety ‐ FOSA GR‐2013‐ 02359514 Assessing immune responses against the viral neuraminidase to improve influenza vaccine efficacy. Istituto Superiore di Sanita' Di Martino Angela Biomedica Immunology Vaccines Against Microbial Diseases ‐ VMD GR‐2013‐ 02359524 Autophagy impairment in patients with chronic HCV infection: impact on steatohepatitis and carcinogenesis. SPALLANZANI Vescovo Tiziana Biomedica Infectious Diseases and Microbiology Virology A and B Study Sections ‐ VIRA and VIRB GR‐2013‐ 02359525 COGNITIVE NEUROGENETICS OF DEVELOPMENTAL DYSLEXIA: FROM GENES TO REHABILITATION MEDEA Mascheretti Sara Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD PASCALE Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 133 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO GR‐2013‐ 02359529 Immunomodulation in Multiple Sclerosis: Estogen receptor alpha role. From the bench to the bedside. GR‐2013‐ 02359531 DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Clerico Marinella Biomedica Immunology Cellular and Molecular Immunology A ‐ CMIA ARCISPEDALE Characterization of the role of SIRT‐dependent deacetylation of C/EBP alpha in the pathogenesis of FLT3‐ ITD+ leukemia Fragliasso Valentina Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC GR‐2013‐ 02359532 NON INVASIVE BRAIN STIMULATION AS ADJUVANT THERAPY FOR DEMENTIA MAGGIORE Mameli Francesca Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02359535 The long‐term impact of severe acquired brain injury (sABI) on coping strategies and quality of life of patients and caregivers: new intervention strategies NEUROLESI Corallo Francesco Clinico‐ Integrative, Functional, assistenzial and Cognitive Neuroscience e Cognitive Neuroscience ‐ COG GR‐2013‐ 02359541 Development and validation of predictive models based on clinical, dosimetric and skin spectrophotometry data for objective selection of breast cancer patients for treatment with intensity modulated radiation therapy ISTITUTO TUMORI MILANO Carrara Mauro Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Oncology 2 ‐ Translational Clinical Small Business [SBIR/STTR] Radiation Therapy and Biology ‐SETA] GR‐2013‐ 02359544 Combining constraint induced movement therapy and BCI‐driven functional electrical stimulation for sensorimotor neuromodulation: enhancing arm functional recovery SANTA LUCIA Morone Giovanni Biomedica Emerging Technologies and Brain Disorders and Training in Neurosciences Related Neurosciences Fellowship ‐ F01 GR‐2013‐ 02359547 Usefulness of Diffusion‐Weighted Magnetic Resonance Abruzzo Imaging in the characterization of uterine malformations. Maccarone Marica Tina Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Reproductive Sciences Small Business SEP ‐ EMNR E11 B GR‐2013‐ 02359549 Diet,microbiota, intestinal barrier function and cancer: new insight for novel therapeutic approaches VETRANO STEFANIA Biomedica Digestive, Kidney and Urological Systems Gastrointestinal Mucosal Pathobiology ‐ GMPB Piemonte HUMANITAS Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 134 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02359550 Mycoplasma pneumoniae post‐infectious encephalitis in children: a model to study the role of infections in the development of autoimmunity GR‐2013‐ 02359555 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Nociti Viviana Biomedica Immunology Immunity and Host Defense ‐ IHD OPIOID ANTAGONISM AND DOPAMINERGIC SYSTEM Lazio IN GAMBLING DISORDER: GENETIC, NEUROIMAGING AND CLINICAL CORRELATES Di Nicola Marco Biomedica Brain Disorders and Clinical Neuroscience Pathophysiological Basis of Mental Disorders and Addictions ‐ PMDA GR‐2013‐ 02359556 Extensive molecular characterization of a large series of benign and malignant mesothelial pleural lesions Toscana Proietti Agnese Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02359561 Cohesins: from Cornelia de Lange Syndrome to leukemia Lombardia Maitz Silvia Beatrice Biomedica Oncology 1 ‐ Basic Translational Cancer Genetics ‐ CG GR‐2013‐ 02359562 Piemonte MIBI scan and molecular markers for a new multidisciplinary diagnostic approach in the management of hypofunctioning thyroid Thy 3 nodules CALANDRI ENRICO Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS GR‐2013‐ 02359563 The Effect of Intrapartum Synthetic Oxytocin and Oxytocin Receptor Polymorphisms on Infant Behavior. STELLA MARIS Prisco Hannah Margareta Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Developmental Brain Disorders ‐ DBD GR‐2013‐ 02359564 CB1 receptor and Kv7 potassium channels: novel molecular targets for the treatment of Duchenne Muscular Dystrophy (DMD) Molise Ambrosino Paolo Biomedica Musculoskeletal, Oral and Skin Sciences Skeletal Biology Development and Disease ‐ SBDD GR‐2013‐ 02359565 Biological characterization of follicular lymphoma to improve diagnosis and treatment modalities: a research proposal from a phase III clinical trial (FIL‐RENOIR12) Provincia autonoma Bolzano Michael Mian Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02359566 Exploring novel molecular targets for the treatment of neurodegenerative diseases FATEBENEFRATELLI Russo Isabella Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN DON GNOCCHI Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 135 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02359570 Analysis of mutational frequency of the genes involved in Sicilia non syndromic hearing loss, study of GJB2 promoter methylation, genotype‐phenotype correlation, establishment of a genetic‐audiological algorithm for early diagnosis and management of patients wit GR‐2013‐ 02359571 Cost analysis of management of elderly Parkinson's disease patients in Italy; benefits in term of quality of life and healthcare costs of an ICT model of tertiary prevention of cognitive decline and motor function through training of the cognitive functio GR‐2013‐ 02359579 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD amorini maria Biomedica SAN RAFFAELE PISANA LIZIO ROBERTA Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD Image‐based high precision hypofractionated Intensity Modulation Radiation Therapy and concurrent Temozolomide in patients affected by Glioblastoma ARCISPEDALE Ciammella Patrizia Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Radiation Therapeutics and Biology ‐ RTB GR‐2013‐ 02359583 Complex needs and Transition from Pediatric to Adult Care in Patients Affected by Neurological Conditions CARLO BESTA Cavallera Vanessa Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD GR‐2013‐ 02359590 A new strategy for the detection of residual leukemia cells Veneto Paganin Maddalena Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02359595 Protective effects of cognitive reserve in glioma patients: Neuropsychological and psychosocial investigations Campanella Fabio Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02359599 Investigation on the functional outcomes of prelingually OSPEDALE BAMBINO deaf children: differences between monaural and binaural GESU' hearing GR‐2013‐ 02359600 Magnetic and electric transcranial brain stimulation for neuro‐rehabilitation purposes: from patho‐physiological concepts to novel treatment strategies Friuli‐Venezia Giulia Lazio Giannantonio Sara Clinico‐ Integrative, Functional, assistenzial and Cognitive Neuroscience e Auditory System ‐ AUD Ferreri Biomedica Clinical Neuroplasticity and Neurotransmitters ‐ CNNT Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Florinda Brain Disorders and Clinical Neuroscience Pagina 136 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02359603 Development of rapid tests for zoonotic Babesia species diagnosis and molecular characterization of strains in order to find new control strategies IZSSI Blanda Valeria Biomedica Infectious Diseases and Microbiology Clinical Research and Field Studies of Infectious Diseases ‐ CRFS GR‐2013‐ 02359609 Non‐paralytic botulinum molecule for the control of migraine pain MONDINO Mangione Antonina Stefania Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02359610 Cognitive and behaviuoral outcome and correlation with MRI findings in children with disorders of cerebellar growth and development, in particular posterior fossa malformations or early fetal cerebellar injury due to preterm birth. CARLO BESTA Bulgheroni Sara Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Developmental Brain Disorders ‐ DBD GR‐2013‐ 02359611 Genomics of triglyceride pathways and dismetabolic, renal, andcardiovascular complications. A new personal genomics approach to an oldproblem. Veneto Martinelli Nicola Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD GR‐2013‐ 02359617 The derailments of the visuo‐attentional and motor development trajectories as early markers for autism spectrum disorder MEDEA Luca Ronconi Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD GR‐2013‐ 02359623 Inhibition of contralesional cerebral motor cortex, through non invasive brain stimulation and constraint induced therapy, in early subacute stroke patients DON GNOCCHI Di Sipio Enrica Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Brain Injury and Neurovascular Pathologies ‐ BINP GR‐2013‐ 02359624 Intensification of antiretroviral therapy with cycles of deferiprone to reduce the amount of total HIV DNA in peripheral blood in HIV‐infected patients on antiretroviral therapy, with undetectable HIV RNA by real‐time PCR (kPCR) Lombardia Cossu Maria Vittoria Biomedica AIDS Discovery and Development of Therapeutics ‐ ADDT GR‐2013‐ 02359628 The use of minimally invasive surgery video systems: 3D vs 2D. Lazio Giordano Valeria Clinico‐ Healthcare Delivery and assistenzial Methodologies e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. AIDS and Related Research Health Services Organization and Delivery ‐ HSOD Pagina 137 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02359633 Use of Olive Oil Polyphenols to prevent Peritoneal Dialysis Technique Failure by Reducing Peritoneum Fibrosis Calabria Vizza Donatella Biomedica Digestive, Kidney and Urological Systems Renal and Urological Sciences Small Business Activities ‐ SERU GR‐2013‐ 02359646 Using Positron Emission Tomography with Florbetapir F18 for detection of cortical amyloid in Alzheimer's Disease: neuropsychological and cerebral metabolic predictors in patients receiving cognitive rehabilitation. SANTA LUCIA Di Iulio Fulvia Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02359648 Building prediction models of accumulation of long‐term CASA SOLLIEVO SOFFERENZA disability and cognitive impairment in patients with multiple sclerosis integrating structural and functional MRI measures across disease clinical phenotype: prospective studies of adult and pediatri Copetti Massimiliano Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02359649 Dissection analysis of the white matter anatomy in normal children's brain OSPEDALE BAMBINO GESU' De Benedictis Alessandro Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD GR‐2013‐ 02359656 Evaluation of in vivo and ex vivo biomarkers for the prediction of chemotherapy response incastration resistant metastatic prostate cancer patients: 18F‐ Fluorocholine PET/CT imagingand circulating tumor cells analysis MAUGERI SPINAPOLICE ELENA GIULIA Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS GR‐2013‐ 02359658 ICF as a framework for a new Italian multidisciplinary approach for paediatric rheumatic rehabilitation: a randomised controlled trial Emilia‐Romagna Salghetti Annamaria Clinico‐ Musculoskeletal, Oral and assistenzial Skin Sciences e Musculoskeletal Rehabilitation Sciences ‐ MRS GR‐2013‐ 02359659 Legionellosis and Tourism. A Model of Risk Analysis for cruise ships and lines NEUROLESI Melcarne Lucia Clinico‐ Infectious Diseases and assistenzial Microbiology e Bacterial Pathogenesis ‐ BACP GR‐2013‐ 02359677 DYSLEXIA PREVENTION THROUGH NEUROCOGNITIVE VIDEOGAMES MEDEA Gori Simone Biomedica Developmental Brain Disorders ‐ DBD Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Brain Disorders and Clinical Neuroscience Classificazione 2° liv. Pagina 138 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO GR‐2013‐ 02359679 Duodenum: a key player in the regulation of glucose metabolism GR‐2013‐ 02359684 DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Muscogiuri Giovanna Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Endocrinology, Metabolism, Nutrition and Reproductive Sciences (EMNR) Integrated Review Group Fellowship Panel ‐ F06 OSPEDALE BAMBINO A HUMAN PROTEOME PROJECT INITIATIVE TO GESU' UNVEIL BIOCHEMICAL ,PROTEOMIC AND METABONOMIC VARIATIONS IN CYBRID CELL LINES CARRYING m.13513G>A MUTATION IN ND5 GENE, ASSOCIATED TO DIFFERENT CLINICAL PHENOTYPES. Torraco Alessandra Biomedica Molecular, Cellular, and Developmental Neuroscience Neural Oxidative Metabolism and Death ‐ NOMD GR‐2013‐ 02359688 Crosstalk between adipocytes and breast cancer cells in obesity Campania D'Esposito Vittoria Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME GR‐2013‐ 02359691 Exosomal RNA profiling for ALS early diagnosis Istituto Superiore di Sanita' VINCI RAMONA Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02359693 Epidemiology of Anisakiasis in Italy: a multidisciplinary approach to study the host‐parasite interaction, humans‐ Anisakis in order to elucidate clinical features and diagnostic aspects of Anisakis‐allergy disease. IZSSI Mazzucco Walter Biomedica Population Sciences and Epidemiology Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions ‐ IRAP GR‐2013‐ 02359694 Functional communications network of MiRNAs in High PASCALE Grade Glioma de Antonellis Pasqualino Biomedica Oncology 1 ‐ Basic Translational Tumor Progression and Metastasis ‐ TPM2 GR‐2013‐ 02359696 An integrated and intensive treatment in patients with Mild Cognitive Impairment for preserving cognition and reducing conversion to dementia Brignani Debora Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN Campania FATEBENEFRATELLI Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 139 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02359698 Motor rehabilitation trials in Parkinson Disease: Gait Analysis as objective measure of clinical improvement GR‐2013‐ 02359702 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Marchetti fabio Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN Piemonte From Frontotemporal Lobar Degeneration to Paget Disease of Bone: identifying common pathogenic pathways using integrated genetic and clinical approaches Rubino Elisa Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02359706 Doxycycline Therapy after Endovascular Aneurysm Repair in the Presence of Type II Endoleak gallitto enrico Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR GR‐2013‐ 02359707 Proteolytic effect of matrix metalloproteinases on anti‐ SAN MATTEO tumor necrosis factor (TNF)‐alpha antibodies: possible correlation with response to anti‐TNF‐alpha treatment in patients with inflammatory bowel disease Biancheri Paolo Biomedica Digestive, Kidney and Urological Systems Gastrointestinal Mucosal Pathobiology ‐ GMPB GR‐2013‐ 02359710 High frequency bilateral repetitive trascranial magnetic SAN RAFFAELE MILANO stimulation with H‐coin over the left and right broca¿s areas to improve language function in chronic non‐fluent post stroke aphasic patient. Chieffo Raffaella Biomedica Brain Disorders and Clinical Neuroscience Brain Injury and Neurovascular Pathologies ‐ BINP GR‐2013‐ 02359711 Redefining Recurrent Unipolar Depression by a neuroscience‐based approach. SANTA LUCIA Mazzarini Lorenzo Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Neural Basis of Psychopathology, Addictions and Sleep Disorders ‐ NPAS GR‐2013‐ 02359712 A novel assessment of development of autonomous nervous system in growth restricted fetuses BURLO GAROFALO Stampalija Tamara Clinico‐ Biology of Development assistenzial and Aging e Development‐1 ‐ DEV1 GR‐2013‐ 02359715 Analysis of immune response induced by M.bovis in naturally infected pigs: pathogenetic, epidemiological and public health evaluations IZSSI Amato Benedetta Biomedica Animal Health ‐ ANHE SANTA LUCIA Emilia‐Romagna Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Veterinary Pagina 140 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO GR‐2013‐ 02359720 Inhibiting effect of a fungal polysaccharide on proliferation of melanoma cells GR‐2013‐ 02359722 DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Scarpari Marzia Biomedica Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ‐ ACTS OSPEDALE BAMBINO VIPP project (Vaccination in Immunocompromised GESU' Pediatric Population).Analysis of development and persistence of protective immunity after new and routine vaccinations in immunocompromised pediatric population. Palma Paolo Biomedica Immunology Immunity and Host Defense ‐ IHD GR‐2013‐ 02359724 MRI and biological markers of neurodegeneration in multiple sclerosis Bergsland Niels Peter Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02359729 Evaluation of the epiduroscopy effectiveness in patients Provincia autonoma Trento Violini with chronic low back pain: the role of inflammation as a pathogenic mechanism of pain Alessia Clinico‐ Bioengineering Sciences assistenzial and Technologies e Instrumentation and Systems Development ‐ ISD GR‐2013‐ 02359731 Ex‐vivo activity evaluation of Th17 and invariant NKT cells from malignant pleural mesothelioma patients on standard chemotherapy protocols : prognostic impact to development new biomarkers, better response to chemotherapy and prolonged survival with fewe Piemonte altomare emanuela Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII GR‐2013‐ 02359732 Immunotherapeutic interventions to overcome tumor microenvironment‐related escape mechanisms in Adoptive Cellular Therapy approaches for CD30+ lymphoma OSPEDALE BAMBINO GESU' DE ANGELIS BIAGIO Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII GR‐2013‐ 02359736 Evaluation of wild and captive dolphin welfare in a program of dolphin‐watching for patients affected by mental illness. IZSPLV diana greta Biomedica Veterinary Animal welfare ‐ ANWE GR‐2013‐ 02359738 Amniotic stem cells‐derived vesicles: their role as mediators of endometrial regeneration. Marche Corradetti Alessandra Biomedica Cell Biology Intercellular Interactions ‐ ICI SAN GALLICANO DON GNOCCHI Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 141 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02359739 Exploring pathogenetic mechanisms of genetic inflammation‐related epilepsies: human and animal studies. OSPEDALE BAMBINO GESU' Specchio Nicola Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD GR‐2013‐ 02359740 Biomarkers for new therapeutic strategies in Alzheimer's Disease: neuroimaging studies Sicilia Paterniti Irene Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Cell Death in Neurodegeneration ‐ CDIN GR‐2013‐ 02359742 I.N.R.C.A. QoLITech: A methodological framework and toolkit to evaluate the Quality of Life Improvement with new Technologies in the ageing population with neurological and cardiovascular diseases for the empowerement of the health care services. Bevilacqua Roberta Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD GR‐2013‐ 02359747 Molecular bases in stroke rehabilitation: an epigenomic study Di Lorenzo Cherubino Biomedica Genes, Genomes and Genetics Molecular Genetics ‐ MGA GR‐2013‐ 02359748 Lazio IDENTIFICATION AND CHARACTERIZATION OF GENES/PATHWAYS PROGNOSTIC OF HIGH RISK OF RELAPSE‐METASTASES IN BREAST AND COLORECTAL RESIDUAL TUMORS FOLLOWING NEOADJUVANT THERAPY milano annalisa Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP GR‐2013‐ 02359751 Perioperative levosimendan in high risk patients undergoing non‐cardiac surgery. A multicenter randomized trial. SAN RAFFAELE MILANO Lembo Rosalba Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma ‐ SAT GR‐2013‐ 02359756 Development and evaluation of hands‐on tools for the control of foodborne pathogens in leafy vegetables IZSPLV Bellio Alberto Biomedica Veterinary Food Safety ‐ FOSA GR‐2013‐ 02359763 Ulysses on the wheelchair: nostalgia as comforting tool SANTA LUCIA Bello Annalisa Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Acute Neural Injury and Epilepsy ‐ ANIE GR‐2013‐ 02359764 Assessment of tumor hypoxia in patients with cervical cancer: impact of 18F‐FAZA PET/CT on personalized treatment SAN RAFFAELE MILANO MAPELLI PAOLA Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC DON GNOCCHI Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 142 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02359765 AhR role in thyroid malignancies I. O. V. Barollo Susi Biomedica GR‐2013‐ 02359773 Evidence‐based pathways of care for chronic diseases: socioeconomic differences in access and health outcomes Lazio Belleudi Valeria Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD GR‐2013‐ 02359774 Prostaglandin D2 synthase (PTGDS) and myelin SAN RAFFAELE MILANO degeneration in peripheral nervous system: identification of new signal pathways to treat chronic complications of Diabetes TRIMARCO AMELIA Biomedica Molecular and Cellular Endocrinology ‐ MCE GR‐2013‐ 02359775 Longitudinal evolution and clinical impact of neurodegeneration and myelin loss and repair in early relapsing‐remitting and primary‐progressive Multiple Sclerosis NEUROLESI Battaglini Marco Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02359777 INDICATION: INtellectual Disability Imaging ChAracterizaTION MEDEA Peruzzo Denis Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD GR‐2013‐ 02359779 TARGETING THE PI3K/mTOR NETWORK TO IDENTIFY NEW POTENTIAL DRUGS IN PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA BURLO GAROFALO Simioni Carolina Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB GR‐2013‐ 02359781 Community Care 2.0 NEUROLESI Carilli Paolo Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD GR‐2013‐ 02359783 Quality of life in oral cancer survivors: a protocol for assessment and management. Sicilia Di Fede Veronica Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Endocrinology, Metabolism, Nutrition and Reproductive Sciences Endocrinology, Metabolism, Nutrition and Reproductive Sciences Endocrinology, Metabolism, Nutrition and Reproductive Sciences (EMNR) Integrated Review Group Fellowship Panel ‐ F06 Pagina 143 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02359787 2‐hydroxylglutarate (2HG) and isocitrate dehydrogenase (IDH1/2) mutations as molecular markers and targeted‐ immunotherapy in gliomas. CARLO BESTA Anghileri Elena Biomedica GR‐2013‐ 02359790 How to choose virtual reality protocol: motivation, attention and physiological changes in different interactive environments DON GNOCCHI alviti federica Clinico‐ Emerging Technologies and Neurotechnology ‐ assistenzial Training in Neurosciences NT e GR‐2013‐ 02359801 HEPATITIS E VIRUS: AN EMERGING INFECTIOUS DISEASE IN ITALY. MOLECULAR DETECTION AND CHARACTERIZATION OF ISOLATES BY THE NOVEL NEXT GENERATION SEQUENCING TECHNOLOGY Istituto Superiore di Sanita' Taffon Stefania Biomedica GR‐2013‐ 02359803 NODAL AND PARANODAL COMPONENTS AS MONDINO AUTOIMMUNE TARGETS IN INFLAMMATORY DEMYELINATING DISORDERS OF THE CENTRAL AND PERIPHERAL NERVOUS SYSTEM Cortese Andrea Clinico‐ Immunology assistenzial e Hypersensitivity, Autoimmune, and Immune GR‐2013‐ 02359806 Role of Thymic stromal lymphopoietin on immune cell polarisation and cancer development Fornasa Giulia Clinico‐ Immunology assistenzial e Immunology Fellowships and Area ‐ F07 GR‐2013‐ 02359807 T cell‐mediated senescence induction: an unrevealed role SANTA LUCIA for CD8+ lymphocytes in multiple sclerosis? Di Mitri Diletta Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT GR‐2013‐ 02359809 Construction of genomic libraries of Mycobacterium Bovis for the identification of new antigensas vaccine candidates IZSSI Mandanici Francesca Biomedica Immunology Vaccines Against Microbial Diseases ‐ VMD GR‐2013‐ 02359817 EVALUATION OF THE APPROPRIATENESS OF PRESCRIPTION AND INTERACTION OF MEDICATIONS IN ELDERLY PATIENTS WITH MULTIPLE DISEASE Campania Trimarco Valentina Biomedica Healthcare Delivery and Methodologies Health Services Organization and Delivery ‐ HSOD GR‐2013‐ 02359823 Mild cognitive impairment and safe driving ability: evaluation with motion analysis in virtual reality. DON GNOCCHI Imbimbo Isabella Clinico‐ Integrative, Functional, assistenzial and Cognitive Neuroscience e I.E.O. Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Oncology 2 ‐ Translational Clinical Infectious Diseases and Microbiology Cancer Biomarkers ‐ CBSS Infectious Diseases and Microbiology Fellowship ‐ F13 Cognitive Neuroscience ‐ COG Pagina 144 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE GR‐2013‐ 02359834 DECIPHERING ETIOLOGY FOR APPROPRIATE CLINICAL CARE : INVESTIGATING MICROCEPHALY‐ NEURODEVELOPMENTAL IMPAIRMENT‐ SKELETAL ANOMALIES IN PEDIATRIC AGE GR‐2013‐ 02359839 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Milani Donatella Clinico‐ Genes, Genomes and assistenzial Genetics e Genetics of Health and Disease ‐ GHD Physical exercise for prevention of dementia: a Molise randomized, parallel‐group, observer‐blinded clinical trial Cristofano Adriana Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN GR‐2013‐ 02359850 DON GNOCCHI Noninvasive brain stimulation (NIBS) in patients with Charcot‐Marie‐Tooth disease. Strengthening the learning of functional strategies. Paolasso Ilaria Clinico‐ Emerging Technologies and Neurotechnology ‐ assistenzial Training in Neurosciences NT e GR‐2013‐ 02359853 64Cu‐Cl2 in prostate cancer for diagnostic detection of lymph node and bone metastases and for metabolic radiotherapy I. O. V. NEGRI ANNA Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Radiation Therapeutics and Biology ‐ RTB GR‐2013‐ 02359858 INCIDENCE AND PROGNOSTIC VALUE OF DIAPHRAGM DYSFUNCTION EVALUATED WITH TRANS‐THORACIC ULTRASOUND IN ACUTE RESPIRATORY FAILURE SECONDARY TO ACUTE EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE Emilia‐Romagna Antenora Federico Biomedica Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR NET‐2013‐ 02355002‐1 Thalidomide, a novel immunological treatment to modify BURLO GAROFALO the natural history of paediatric Crohn's disease: a new proposal from a well‐established paediatric research network. Ventura Alessandro Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Clinical, Integrative and Molecular Gastroenterology ‐ CIMG Badolato Raffaele Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Clinical, Integrative and Molecular Gastroenterology ‐ CIMG Toffoli Giuseppe Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Clinical, Integrative and Molecular Gastroenterology ‐ CIMG NET‐2013‐ Genetic and immunological study of children with 02355002‐2 Crohn's disease receiving thalidomide treatment MAGGIORE Lombardia NET‐2013‐ Evaluation of the effect of pharmacokinetic, metabolomic C.R.O. AVIANO 02355002‐3 and pharmacogenomic, profiles of thalidomide on response and toxicity in children with Crohn's disease Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Cardiovascular and Respiratory Sciences Pagina 145 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE NET‐2013‐ 02355021‐1 Liguria New emerging technologies and their translational application to genomic medicine: genetic laboratories automation, from Sanger sequencing to targeted NGS chip design for the molecular diagnosis of genetic disease, cost analysis using ABC model for an app Coviello NET‐2013‐ 02355021‐2 Certification, quality and cost analysis of genetic testing, and assessment of genetic counselling offered by genetic services. National survey and international data base connections. OSPEDALE BAMBINO GESU' NET‐2013‐ 02355021‐3 Cost analysis plan of new genomic technologies using different operative models for an efficient benchmarking and appropriate allocation of NHS recourses. NET‐2013‐ 02355021‐4 Classificazione 1 Liv. Classificazione 2° liv. Domenico Clinico‐ Genes, Genomes and assistenzial Genetics e Genetics of Health and Disease ‐ GHD Lepri Francesca Romana Clinico‐ Genes, Genomes and assistenzial Genetics e Genetics of Health and Disease ‐ GHD RIZZOLI Sangiorgi Luca Clinico‐ Genes, Genomes and assistenzial Genetics e Genetics of Health and Disease ‐ GHD The clinical risk management in Medical Genetics Piemonte amoroso antonio Clinico‐ Genes, Genomes and assistenzial Genetics e Genetics of Health and Disease ‐ GHD NET‐2013‐ 02355116‐1 Coordination of large national cohorts of patients with chronic HCV infection: data management, monitoring and centralized data analysis. Istituto Superiore di Sanita' Kondili Loreta Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS NET‐2013‐ 02355116‐2 Strategic use of new DAA combinations in HCV patients with HIV and/or HBV coinfection Lombardia Massimo Puoti Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS NET‐2013‐ 02355116‐3 Difficult to treat HCV populations in the era of new direct Lazio acting antivirals (DAAs) Gasbarrini Antonio Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS NET‐2013‐ 02355116‐4 HCV infection in difficult to reach, vulnerable, underserved populations, and gender issues. Villa Erica Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS Emilia‐Romagna Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Pagina 146 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE NET‐2013‐ 02355116‐5 Pharmaco‐economics of the new DAAs for the treatment Sicilia of chronic HCV infection NET‐2013‐ 02355170‐1 Feasibility and effects on body composition of a life style intervention with diet and exercise in early breast cancer (BC) patients. NET‐2013‐ 02355170‐2 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Craxì Antonio Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS Liguria Gennari Alessandra Biomedica Oncology 2 ‐ Translational Clinical Chemo/Dietary Prevention ‐ CDP Development of a clinical algorithm for a dynamic prognosistic assessment in patients with early breast cancer entered in a lifestyle modifying intervention program IRCCS AOU San Martino‐ IST (Genova) BRUZZI PAOLO Biomedica Oncology 2 ‐ Translational Clinical Chemo/Dietary Prevention ‐ CDP NET‐2013‐ 02355170‐3 Impact of a radical lifestyle intervention in early breast cancer on the level of expression of selected circulating miRNA known to be related to BC prognosis Istituto Scientifico Romagnolo Nanni Oriana Biomedica Oncology 2 ‐ Translational Clinical Chemo/Dietary Prevention ‐ CDP NET‐2013‐ 02355170‐4 Evaluation of the impact on patient metabolism of a lifestyle intervention, including Mediterranean Diet and Physical activity in early breast cancer (BC) patients. Toscana Quinones‐ Galvan Alfredo Biomedica Oncology 2 ‐ Translational Clinical Chemo/Dietary Prevention ‐ CDP NET‐2013‐ 02355196‐1 Pathways to Recovery from Mental Illness. From rehabilitation to education and self‐management: the Recovery College Model.A study to evaluate the impact of the partecipation to training groups based on the Recovery Capital approach on individual pathway Lombardia lucchi fabio Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD NET‐2013‐ 02355196‐2 The role of Users and Family Members in Peer Support.A study to assess methods and practices of users involvement in mental health services delivery and its impact on treatment outcomes, on the culture of the service workforce and stakeholders of local c Provincia autonoma Trento De Stefani Renzo Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 147 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE NET‐2013‐ 02355196‐3 Emilia‐Romagna Supporting Organisations towards Coproduction and Recovery: a peer‐accreditation process among all the relevant stakeholders in the mental health field to design, test and implement an instrument to assess, monitor and support organisations that choose c NET‐2013‐ 02355196‐4 Personalisation in Mental Health. A qualitative research on promising and best‐practices to promote personalisation in mental health care plans and on the implementation and evaluation of innovative interventions across the sites of the Project. NET‐2013‐ 02355196‐5 Piemonte Individualized Care Plans (ICPs): Users and their carers in the "driver's seat".A study to compare the outcomes of ICPs coproduced by users, their carers with mental health services key‐workers vs standard ICPs based on the preminence of professionals. NET‐2013‐ 02355234‐1 Clinical efficacy and cost‐effectiveness of Telerehabilitation for post‐Stroke and post Traumatic Brain Injury patients in comparison with usual territorial rehabilitation, analyzed in two different organizational models. NET‐2013‐ 02355234‐2 NET‐2013‐ 02355234‐3 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Fioritti Angelo Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD Mezzina Roberto Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD Geda Giovanni Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD S.CAMILLO Tonin Paolo Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD TELEREHABILITATION IN SEVERE ACQUIRED BRAIN INJURY: IS IT EFFECTIVE? NEUROLESI Calabrò Rocco Salvatore Clinico‐ Clinical efficacy of Telerehabilitation on motor and cognitive disorders in Parkinson's disease in comparison with standard rehabilitation MONDINO Sinforiani CARLO BESTA Raggi NET‐2013‐ Blind assessment of outcome measures in 02355234‐4 Telerehabilitation for neurological patients and caregivers' burden, and contribution to a randomised non‐inferiority clinical trial on patients with sequelae of Stroke Friuli‐Venezia Giulia Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD Elena Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD Alberto Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD Pagina 148 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA NET‐2013‐ 02355234‐5 Health Technology Assessment of different care models in telerehabilitation Istituto Superiore di Sanita' Giacomozzi Claudia Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD NET‐2013‐ 02355263‐1 Non invasive tools for early surveillance of at‐risk populations Istituto Superiore di Sanita' Scattoni Maria Luisa Clinico‐ Biobehavioral and assistenzial Behavioral Processes e Child Psychopathology and Developmental Disabilities ‐ CPDD P.I. Classificazione 1 Liv. Classificazione 2° liv. NET‐2013‐ An integrated specialist web network for early screening 02355263‐2 of ASD MEDEA Molteni Massimo Clinico‐ Biobehavioral and assistenzial Behavioral Processes e Child Psychopathology and Developmental Disabilities ‐ CPDD NET‐2013‐ 02355263‐3 STELLA MARIS Muratori Filippo Clinico‐ Biobehavioral and assistenzial Behavioral Processes e Child Psychopathology and Developmental Disabilities ‐ CPDD NET‐2013‐ OMICS biomarkers for better care in Autism Spectrum 02355263‐4 Disorders Lazio Persico Antonio Maria Clinico‐ Biobehavioral and assistenzial Behavioral Processes e Child Psychopathology and Developmental Disabilities ‐ CPDD NET‐2013‐ 02355263‐5 Predictors of outcomes in autism early behavioral intervention OSPEDALE BAMBINO GESU' Vicari Stefano Clinico‐ Biobehavioral and assistenzial Behavioral Processes e Child Psychopathology and Developmental Disabilities ‐ CPDD NET‐2013‐ 02355297‐1 Development and standardization of a Cognitive evoked potentials and Low resolution computed tomography (LORETA) protocol in children with SCD and in age‐ ethnic matched controls Veneto SAINATI LAURA Clinico‐ Vascular and Hematology assistenzial e Erythrocyte and Leukocyte Biology ‐ ELB Emilia‐Romagna palazzi giovanni Clinico‐ Vascular and Hematology assistenzial e Erythrocyte and Leukocyte Biology ‐ ELB EARLY BIRD DIAGNOSTIC PROTOCOL FOR AUTISM SPECTRUM DISORDERS (EARLY BIRD) NET‐2013‐ Development and standardization of a Neuro‐Cognitive 02355297‐2 Protocol to evaluate monolingual and bilingual infants, pre‐school and school age children with Sickle Cell Disease Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 149 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE NET‐2013‐ Development and standardization of a Sleep study 02355297‐3 questionnaire and Polysomnography protocol in a multiethnic population of children with Sickle Cell Disease Lombardia Campania NET‐2013‐ Development and standardization of a MRI/MRA, 02355297‐4 Functional MRI protocol since young age in a multiethnic population of children with Sickle Cell Disease AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. MASERA NICOLETTA Clinico‐ Vascular and Hematology assistenzial e Erythrocyte and Leukocyte Biology ‐ ELB PERROTTA SILVERIO Clinico‐ Vascular and Hematology assistenzial e Erythrocyte and Leukocyte Biology ‐ ELB NET‐2013‐ 02355313‐1 MONDINO Improved detection of hippocampal and extra‐ hippocampal abnormalities in temporal lobe epilepsy by an advanced MRI 3T protocol, including multiparametric mapping (MPM), diffusion tensor imaging (DTI) and arterial spin labeling (ASL), to assess macrostruct Vitali Paolo Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Acute Neural Injury and Epilepsy ‐ ANIE NET‐2013‐ 02355313‐2 Surgically treatable temporal lobe epilepsy: in‐vivo 3T MRI, ex‐vivo 7T MRI and histological correlations CARLO BESTA Didato Giuseppe Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Acute Neural Injury and Epilepsy ‐ ANIE NET‐2013‐ 02355313‐3 Brain networks involved in temporal lobe epilepsy as revealed by EEG‐fMRI co‐registration. A national multi‐ centric study. Emilia‐Romagna Meletti Stefano Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Acute Neural Injury and Epilepsy ‐ ANIE NET‐2013‐ 02355333‐1 Study of host/virus interactions involved in HIV control, in patient treated with a multitarget antiretroviral (MT‐ ART) therapy during primary HIV infection (PHI). SAN RAFFAELE MILANO Tambussi Giuseppe Biomedica AIDS and Related Research AIDS Clinical Studies and Epidemiology ‐ ACE NET‐2013‐ 02355333‐2 Virologic evolution in different compartments in patients Lombardia receiving multitarget antiviral therapy (MT‐ART) during primary HIV infection (PHI) Rusconi Stefano Biomedica AIDS and Related Research AIDS Clinical Studies and Epidemiology ‐ ACE NET‐2013‐ 02355333‐3 Lymphoid architecture and homeostasis in lymphnodes, Lombardia gut and peripheral blood in HIV‐infected patients during primary HIV infection (PHI) and changes upon multitarget antiretroviral therapy (MT‐ART) Marchetti Giulia Carla Biomedica AIDS and Related Research AIDS Clinical Studies and Epidemiology ‐ ACE Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 150 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE NET‐2013‐ 02355333‐4 Plasma, intracellular and tissue concentrations reached by a multitarget antiretroviral therapy (MT‐ART) during the treatment of patients with primary HIV infection (PHI): a pharmacokinetic/pharmacodynamic study NET‐2013‐ 02355333‐5 New model of Primary HIV infection (PHI) management: Lombardia identification of PHI, standardization of antiretroviral treatment and data collection in a nationwide Italian network (INACTION) NET‐2013‐ 02355352‐1 ALLOGENEIC TRANSFUSION OF RED BLOOD CELL CONCENTRATES FROM CORD BLOOD UNITS IN EXTREMELY LOW BIRTH WEIGHT PRETERM INFANTS: COMPARATIVE ANALYSIS OF CUMULATIVE INCIDENCE OF PREMATURITY RELATED DISEASES BETWEEN PATIENTS RECEIVING CORD BLOOD OR ADULT BLOOD NET‐2013‐ 02355352‐2 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Calcagno Andrea Biomedica AIDS and Related Research AIDS Clinical Studies and Epidemiology ‐ ACE Muscatello Antonio Biomedica AIDS and Related Research AIDS Clinical Studies and Epidemiology ‐ ACE Lazio Zini Gina Clinico‐ Vascular and Hematology assistenzial e Erythrocyte and Leukocyte Biology ‐ ELB ALLOGENEIC TRANSFUSION OF RED BLOOD CELL (RBC) CONCENTRATES FROM CORD BLOOD IN EXTREMELY LOW BIRTH WEIGHT PRETERM INFANTS: MICROPARTICLE CHARACTERIZATION IN CORD BLOOD AND ADULT DONOR RBC UNITS. CASA SOLLIEVO SOFFERENZA SANTODIROC MICHELE CO Clinico‐ Vascular and Hematology assistenzial e Erythrocyte and Leukocyte Biology ‐ ELB NET‐2013‐ 02355352‐3 ALLOGENEIC TRANSFUSION OF CORD BLOOD RED BLOOD CELL (RBC) CONCENTRATES IN EXTREMELY LOW BIRTH WEIGHT NEONATES: COMPARISON OF IMMUNOMODULATION AND EFFECT ON LYMPHOCYTE SUBSETS EXERTED BY CORD BLOOD OR ADULT BLOOD PRODUCTS. Abruzzo Accorsi Patrizia Clinico‐ Vascular and Hematology assistenzial e Erythrocyte and Leukocyte Biology ‐ ELB NET‐2013‐ 02355352‐4 ALLOGENEIC TRANSFUSION OF RED BLOOD CELL CONCENTRATES FROM CORD BLOOD UNITS IN EXTREMELY LOW BIRTH WEIGHT PRETERM INFANTS. Calabria Princi Domenica Clinico‐ Vascular and Hematology assistenzial e Erythrocyte and Leukocyte Biology ‐ ELB Piemonte Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 151 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE NET‐2013‐ 02355461‐1 Novel approaches to the diagnosis of subclinical, unapparent or latent socially relevant infectious diseases in immigrants in Italy and identification of prognostic indexes based on the specific immune response signature NET‐2013‐ 02355461‐2 Assessment of the prevalence, clinical and virological Lombardia characteristics of Viral Hepatitis in immigrants through the implementation of different screening and prevention adjusted to social environment NET‐2013‐ 02355461‐3 Implementation of diagnostic method for diagnosis of tuberculosis in recently immigrants from TB high endemic area NET‐2013‐ 02355461‐4 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Carlo Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS Castelli Francesco Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS Lichtner Miriam Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS Calabria Screening for infectious diseases in recent migrants and evaluation of the specific immune responses for diagnosis driven treatment and prevention strategies. Torti Carlo Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS NET‐2013‐ 02355461‐5 Screening for clinically unapparent infectious diseases at Puglia high social impact in recently immigrants from Africa for early diagnosis and appropriate treatment Angarano Gioacchino Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS NET‐2013‐ 02355555‐1 Improving Transition Process in major psychoses MEDEA Martinuzzi Andrea Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD NET‐2013‐ 02355555‐2 Transition in Cystic Fibrosis: comparing management models to improve quality of care OSPEDALE BAMBINO GESU' lucidi vincenzina Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD NET‐2013‐ 02355555‐3 Improving Transition Process in severe Myopathies GASLINI Minetti Carlo Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD NET‐2013‐ 02355555‐4 Psychosocial and biological factors influencing the transition from adolescence to early adulthood Istituto Superiore di Sanita' Angelo Picardi Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD Istituto Superiore di Sanita' Severini Lazio Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 152 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO NET‐2013‐ 02355555‐5 Improving transition for autism spectrum disorders Lombardia Politi Pierluigi Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD NET‐2013‐ 02355666‐1 Dynamic MR imaging of the pelvic floor functional disorders: a comparison between sitting and supine position. Sicilia Midiri Massimo Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Biomedical Imaging Technology ‐ BMIT NET‐2013‐ Dynamic MR imaging of the pelvic floor functional 02355666‐2 disorders: a comparison between sitting and supine position. Campania GRASSI ROBERTO Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Biomedical Imaging Technology ‐ BMIT NET‐2013‐ Dynamic MR imaging of the pelvic floor functional 02355666‐3 disorders: a comparison between sitting and supine position. Lazio Orlacchio Antonio Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Biomedical Imaging Technology ‐ BMIT NET‐2013‐ 02355787‐1 Istituto Superiore di Sanita' Comba Pietro Biomedica Population Sciences and Epidemiology Social Sciences and Population Studies ‐ ZRSS NET‐2013‐ Cancer incidence in contaminated sites, with a focus on 02355787‐2 children Toscana Crocetti Emanuele Biomedica Population Sciences and Epidemiology Social Sciences and Population Studies ‐ ZRSS NET‐2013‐ Individual‐based cohort studies on air quality and 02355787‐3 cardiorespiratory diseases in industrial sites: indicators for public health policy Lazio Ancona Carla Biomedica Population Sciences and Epidemiology Social Sciences and Population Studies ‐ ZRSS NET‐2013‐ Environment‐related diseases in contaminated sites: the 02355787‐4 response of health services Piemonte Magnani Corrado Biomedica Population Sciences and Epidemiology Social Sciences and Population Studies ‐ ZRSS Saglio Giuseppe Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e NET‐2013‐ 02355812‐1 DESTINATARIO ISTITUZIONALE Epidemiological surveillance in contaminated sites: improvements in study design and implementation of SENTIERI KIDS Project Piemonte Molecular markers and innovative technologies predictive of succesful treatment discontinuation in CML patients receiving tyrosine kinase inhibitors Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Cancer Biomarkers ‐ CBSS Pagina 153 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE NET‐2013‐ 02355812‐2 Campania Profile of Bone Marrow microenvironment biological markers in CML patients treated with TKIs: development a novel diagnostic tools Pane Fabrizio Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS NET‐2013‐ 02355812‐3 Optimization of TKIs Multiple Approaches and quality of Lombardia life (QoL) in elderly patients (60 years of age or older) with Ph+ chronic myeloid leukemia (CML) and MR3.0 / MR4.0 stable molecular response Russo Domenico Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS NET‐2013‐ 02355812‐4 High‐resolution genomic and metabolic characterization Emilia‐Romagna of leukemia stem cells to predict successful treatment discontinuation in chronic myeloid leukemia patients Martinelli Giovanni Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS NET‐2013‐ 02356160‐1 Pediatric ataxias in Italy: epidemiological studies and disease registry, development of a multi‐level informatic platform for clinicians and families, and implementation of guidelines for diagnosis, management and care within the National Health System Nicola Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Developmental Brain Disorders ‐ DBD NET‐2013‐ 02356160‐2 Improving genetic diagnosis of pediatric ataxias: CASA SOLLIEVO identification of novel genetic determinants, large scale SOFFERENZA molecular screenings and genotype‐phenotype correlates by use of state‐of‐the‐art genomic technologies Valente Enza Maria Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Developmental Brain Disorders ‐ DBD NET‐2013‐ 02356160‐3 OSPEDALE BAMBINO Development of innovative low‐cost, widely accessible technologies for quantitative assessment and home‐based GESU' rehabilitation of motor function in pediatric ataxias Bertini Enrico Silvio Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Developmental Brain Disorders ‐ DBD MEDEA NET‐2013‐ Cognitive and behavioral defects in non‐progressive 02356160‐4 pediatric ataxias: systematic cognitive profiling, innovative neuroimaging studies and development of low‐ cost, widely accessible technologies for personalized home‐based rehabilitation Borgatti Renato Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Developmental Brain Disorders ‐ DBD NET‐2013‐ 02356185‐1 Lazzarotto Tiziana Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS Istituto Superiore di Sanita' Vanacore Standardizing virological methods for the diagnosis, Emilia‐Romagna monitoring and presymptomatic treatment of CMV and EBV infections in adult and pediatric stem cell transplant recipients. Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 154 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE NET‐2013‐ 02356185‐2 Clinical surveillance models and viral DNA cut‐off for pre‐ Lombardia symptomatic treatment of CMV and EBV infections in adult high‐risk stem cells transplant recipients. Farina Claudio francesco Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS NET‐2013‐ 02356185‐3 Clinical surveillance models and viral DNA cut‐off for pre‐ SAN MATTEO symptomatic treatment of CMV and EBV infections in pediatric stem cells transplant recipients Giorgiani Giovanna Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS NET‐2013‐ 02356185‐4 Clinical surveillance models and viral DNA cut‐off for pre‐ Lazio symptomatic treatment of CMV and EBV infections in adult and pediatric low‐risk stem cells transplant recipients. Gentile Giuseppe Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS NET‐2013‐ 02356185‐5 Evaluation of CMV and EBV‐specific cellular immune responses in hematopoietic stem cell transplant recipients to prevent and control viral infection. Piemonte Cavallo Rossana Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS NET‐2013‐ 02356202‐1 Gender‐oriented molecular characterization of Hepatocellular Carcinoma (HCC) associated with Diabetes and Obesity: impact on clinical aggressiveness and survival. Emilia‐Romagna De Maria Nicola Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO Emilia‐Romagna NET‐2013‐ Active screening for chronic liver disease and HCC in 02356202‐2 diabetics and gender‐oriented epidemiology via the ¿RER Diabetes Care Net¿ Manicardi valeria Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO NET‐2013‐ Comparative imaging and locoregional treatment 02356202‐3 outcome in diabetes/NASH vs. viral HCCs ARCISPEDALE massari marco Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO NET‐2013‐ Gender burden assessment in development, progression, 02356202‐4 therapy and self‐management of diabetes, obesity and related‐conditions Emilia‐Romagna Signani Fulvia Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 155 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE NET‐2013‐ 02356597‐1 Fecal Microbiota Transplantation (FMT) program: Realization of regional referral centers for the treatment of recurrent Clostridium difficile infection by FMT. AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Lazio Cammarota Giovanni Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD NET‐2013‐ Fecal Microbiota Transplantation (FMT) program: 02356597‐2 Realization of regional referral centers for the treatment of recurrent Clostridium diffcile infection by FMT. Emilia‐Romagna Bazzoli Franco Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD NET‐2013‐ Fecal Microbiota Transplantation (FMT) program: 02356597‐3 Realization of regional referral centers for the treatment of recurrent Clostridium diffcile infection by FMT. Lombardia Maconi Giovanni Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD NET‐2013‐ Fecal Microbiota Transplantation (FMT) program: 02356597‐4 Realization of regional referral centers for the treatment of recurrent Clostridium diffcile infection by FMT. Abruzzo Neri Matteo Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD NET‐2013‐ 02356764‐1 I.N.R.C.A. Lattanzio Fabrizia Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO NET‐2013‐ Geriatric outcomes among older Type 2 diabetic patients 02356764‐2 treated with DPP4 inhibitors or glinides: focus on physical functioning Lazio Bernabei Roberto Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO NET‐2013‐ Geriatric outcomes among older Type 2 diabetic patients 02356764‐3 treated with DPP4 inhibitors or glinides: focus on cognitive functioning Campania Paolisso Giuseppe Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO NET‐2013‐ 02356934‐1 Toscana Palli Domenico Biomedica Population Sciences and Epidemiology Epidemiology of Cancer ‐ EPIC Piemonte Segnan Nereo Biomedica Population Sciences and Epidemiology Epidemiology of Cancer ‐ EPIC Geriatric outcomes among older Type 2 diabetic patients treated with DPP4 inhibitors or glinides: focus on pro‐ inflammatory and oxidative stress markers A sustainable strategy for the prevention of recurrences and risk reduction in breast cancer patients based on permanent life‐style modifications: a randomized intervention trial to evaluate a one‐year protocol aimed to obtain dietary and physical activit NET‐2013‐ Evaluation of the clinical performance of Digital Breast 02356934‐2 Tomosynthesis (DBT) as a primary test for breast cancer screening: a multicentre randomized trial Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 156 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. NET‐2013‐ Identification of a tailored protocol and a risk reduction 02356934‐3 strategy for breast cancer in affected and unaffected BRCA1/2 carriers and in familial breast cancer high risk subjects Evaluation of the feasibility of the protocol in different areas in the Toscana Caligo Maria Adelaide Biomedica Population Sciences and Epidemiology Epidemiology of Cancer ‐ EPIC NET‐2013‐ Digital breast tomosynthesis as a primary test for breast 02356934‐4 cancer screening: assessment of safety, accuracy, cost‐ effectiveness and organizational impact. Emilia‐Romagna Giorgi Rossi Paolo Biomedica Population Sciences and Epidemiology Epidemiology of Cancer ‐ EPIC NET‐2013‐ Human‐mouse co‐clinical trials to tailor chemotherapy 02356949‐1 for ovarian cancer Piemonte Katsaros Dionyssios Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS NET‐2013‐ Identification of a panel of biomarkers able to predict 02356949‐2 response to bevacizumab in women with advanced high‐ grade serous ovarian cancer receiving neoadjuvant chemotherapy Lazio Scambia Giovanni Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS NET‐2013‐ Targeted therapy in ovarian cancer with novel anti‐ 02356949‐3 angiogenic and anti‐PARP drug combinations: efficacy and predictive biomarkers I.E.O. COLOMBO NICOLETTA Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS NET‐2013‐ XENO‐PATIENTS co‐clinical trial to validate novel 02356949‐4 treatment modalities in ovarian cancer MARIO NEGRI Giavazzi Raffaella Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS NET‐2013‐ 02357109‐1 Cerebral Cavernous Malformations: from clinic to disease Lombardia mechanisms toward prevention and treatment Fontanella Marco Maria Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Brain Injury and Neurovascular Pathologies ‐ BINP NET‐2013‐ 02357109‐2 Cerebral Cavernous Malformations: from clinic to disease Piemonte mechanisms toward prevention and treatment Rainero Innocenzo Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Brain Injury and Neurovascular Pathologies ‐ BINP NET‐2013‐ 02357109‐3 Cerebral Cavernous Malformations: from clinic to disease Toscana mechanisms toward prevention and treatment Battistini Stefania Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Brain Injury and Neurovascular Pathologies ‐ BINP Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 157 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA NET‐2013‐ 02357109‐4 Cerebral Cavernous Malformations: from clinic to disease Veneto mechanisms toward prevention and treatment denaro luca Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Brain Injury and Neurovascular Pathologies ‐ BINP NET‐2013‐ 02357109‐5 Cerebral Cavernous Malformations: from clinic to disease Abruzzo mechanisms toward prevention and treatment Splendiani Alessandra Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Brain Injury and Neurovascular Pathologies ‐ BINP NET‐2013‐ 02357159‐1 A translational approach to investigate the biomolecular role of Vitamin D in pediatric obesity and insulin resistance Piemonte Bona Gianni Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative Physiology of Obesity and Diabetes ‐ IPOD NET‐2013‐ 02357159‐2 Micro‐RNA Regulation: Understanding, predicting, diagnosing and treatingNAFLD and obesity‐related complications in Childhood Emilia‐Romagna Street Maria Elisabeth Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative Physiology of Obesity and Diabetes ‐ IPOD NET‐2013‐ 02357159‐3 Effects of perfluorinated chemicals (PFCs) levels on growth and insulin resistance inneonates born with adequate or low weight for gestational age Emilia‐Romagna Predieri Barbara Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative Physiology of Obesity and Diabetes ‐ IPOD NET‐2013‐ 02357398‐1 WP1. Development of metagenomics models for culture‐ Istituto Superiore di Sanita' Morabito independent detection and typing of zoonotic pathogens and study of their interactions with the microbiota in the whole animal‐to‐human transmission chain Stefano Biomedica Veterinary Food Safety ‐ FOSA P.I. Classificazione 1 Liv. Classificazione 2° liv. NET‐2013‐ WP2. Development of a next generation sequencing 02357398‐2 (NGS)‐based surveillance system enabling multi‐genome comparisons and improving the control of vector borne viral diseases IZSAM Cammà Cesare Biomedica Veterinary Food Safety ‐ FOSA NET‐2013‐ WP3 ‐ Development of a next generation sequencing 02357398‐3 (NGS)‐based surveillance system enabling multi‐genome comparisons for the effective control of infectious diseases at the animal‐human interface and foodborne zoonoses IZSVE Monne Isabella Biomedica Veterinary Food Safety ‐ FOSA Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 158 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. NET‐2013‐ WP4 ‐ Development of a next generation sequencing 02357398‐4 (NGS)‐based surveillance system enabling multi‐genome comparisons and improving the control of diseases caused by protozoa IZSSI VITALE FABRIZIO Biomedica Veterinary Food Safety ‐ FOSA NET‐2013‐ 02357441‐1 Clinical added value of MEG in surgical planning and patients management and outcome in patients who will undergo to brain surgery for low grade brain tumors, vascular malformations or epilepsy CARLO BESTA Franceschetti Silvana Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD NET‐2013‐ 02357441‐2 Evaluation of the cost‐benefit ratio of S.CAMILLO Magnetoencephalography (MEG) to optimize selection of Stroke and Mild Cognitive Impairment patients requiring early, intensive and prolonged rehabilitation. Piccione Francesco Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD NET‐2013‐ 02357441‐3 Clinical Application of high density EEG and fMRI in epilepsy and neurorehabilitation Manganotti Paolo Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD NET‐2013‐ 02357441‐4 Impact of Magnetoencaphalography in the diagnosis and Abruzzo follow‐up of schizophrenic patients Di Massimo Giannantonio Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD NET‐2013‐ 02357568‐1 Defining a new diagnostic and prognostic biomarkers tool in low risk prostate cancermanagement. PASCALE Perdonà Sisto Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS NET‐2013‐ Defining a new diagnostic and prognostic biomarkers 02357568‐2 tool in low risk prostate cancermanagement. Piemonte Muto Giovanni Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS NET‐2013‐ Defining a new diagnostic and prognostic biomarkers 02357568‐3 tool in low risk prostate cancermanagement. Calabria damiano rocco Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS Mazzon Emanuela Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD NET‐2013‐ 02358003‐1 Veneto Implement technical architecture , data flow organization NEUROLESI and security control systems to extend the regional telepathology network to a national environment. Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 159 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. NET‐2013‐ A project for establishing a telepathology service for 02358003‐2 Anatomic Pathology using whole‐slide imaging. C.R.O. AVIANO Carbone Antonino Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD NET‐2013‐ A project aimed to establish/implement a telepathology 02358003‐3 network and service in selected Anatomic Pathology subspecialties REGINA ELENA Pescarmona Edoardo Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD NET‐2013‐ Campania Thelepathology Network : focus on colorectal 02358003‐4 and skin tumors immunoscore. PASCALE Botti Gerardo Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD Collini Paola Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD ISTITUTO TUMORI NET‐2013‐ Whole‐slide‐imaging telepathology in pediatric tumors 02358003‐5 and soft tissue sarcomas diagnosis. Whole‐slide‐imaging MILANO telepathology applicability to in situ molecular pathology NET‐2013‐ 02358018‐1 INFLUENCE OF DIFFERENT BETABLOCKERS ON HEART FAILURE PROGNOSIS. A PROSPECTIVE ANALISYS MONZINO Agostoni Piergiuseppe Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR NET‐2013‐ 02358018‐2 Breathing pattern during sleep and wakefulness in congestive heart failure patients AUXOLOGICO Lombardi Carolina Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR NET‐2013‐ 02358018‐3 Toscana Evaluation of prognostic accuracy of a multi‐marker model including MECKI score and several cardiac risk biomarkers according to the principles of Evidence‐Based Laboratory Medicine and International Recommended Criteria Clerico Aldo Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR PERRONE FILARDI PASQUALE Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR NET‐2013‐ ROLE OF RESTING AND EXRECISE CHRONOTROPIC 02358018‐4 VARIABLES IN THE PROGNOSIS OF PATIENTS AFFECTED BY HEART FAILURE: NEW INSIGHTS OF THE MECKI SCORE Campania Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 160 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE NET‐2013‐ 02358018‐5 A prospective validation of MECKI score in idiopathic dilated cardiomyopathy: is it time for improving the prognostic stratification of this rare disease? Friuli‐Venezia Giulia Merlo Marco Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR NET‐2013‐ 02358135‐1 Home monitoring of the atrial fibrillation burden. Toscana Padeletti Luigi Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD NET‐2013‐ 02358135‐2 Metabolic and cardiac home monitoring in complicated heart failure/diabetic patients. MULTIMEDICA Genovese Stefano Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD NET‐2013‐ 02358135‐3 Strategies to manage patients with chronic obstructive lung diseases and heart failure at home. Toscana Prediletto Renato Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD NET‐2013‐ 02358135‐4 Preventing Heart Failure progression by home monitor and support at an early stage. Campania Trimarco Bruno Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD NET‐2013‐ 02358135‐5 Preventing Heart Failure progression by home monitor and support at an early stage. Lombardia LUNATI MAURIZIO Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD NET‐2013‐ 02358707‐1 Characterization of the patient's genome for clinical decision making in myelodysplastic syndromes (MDS) SAN MATTEO DELLA PORTA MATTEO GIOVANNI Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC NET‐2013‐ Prospective evaluation of a KIT‐adapted treatment of 02358707‐2 core‐binding factor leukemia (CBFL) in adults and integrated genetic analysis: a multi‐center phase II study Lombardia Morra Enrica Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC NET‐2013‐ Prevalence and clinical significance of c‐KIT somatic 02358707‐3 mutations in hypereosinophilic syndromes MAGGIORE Cortelezzi Agostino Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 161 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. NET‐2013‐ Diffuse large B cell lymphoma (DLBCL) with 02358707‐4 dysregulation of c‐myc gene expression. Dissecting the pathological and molecular heterogeneity to support tailored treatment strategies Lombardia Rossi Giuseppe Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC NET‐2013‐ Definition of patient's unique genetic profile to guide 02358707‐5 therapeutical decision making in myeloproliferative neoplasms (MPN) Lombardia Passamonti Francesco Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC NET‐2013‐ Clonal composition of synchronous colorectal tumors to 02358800‐1 address field effect(s) theory. HUMANITAS Malesci Alberto Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS NET‐2013‐ Epigenetic profiles of early‐onset, synchronous and 02358800‐2 metachronous colorectal cancers. Emilia‐Romagna RICCIARDIELL LUIGI O Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS C.R.O. AVIANO NET‐2013‐ NGS‐based genomic profiling of synchronous and 02358800‐3 metachronous tumors arising in patients with attenuated polyposis Fornasarig Mara Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS NET‐2013‐ Epidemiological, clinical and molecular characterization 02358800‐4 of juvenile CRC. REGINA ELENA Stigliano Vittoria Anna Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS NET‐2013‐ MicroRNA expression profiles as predictors of colorectal 02358800‐5 cancer predisposition Lazio GENUARDI MAURIZIO Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS NET‐2013‐ 02358831‐1 Perinatal factors associated with respiratory infections and their sequelae: the Piccolipiù birth cohort and the network of Pediatric Hospitals Toscana Rusconi Franca Clinico‐ Population Sciences and assistenzial Epidemiology e Social Sciences and Population Studies ‐ SSPS NET‐2013‐ 02358831‐2 Air pollution exposure, socioeconomic characteristics of the family, perinatal maternal psychological distress and child neurodevelopment: the Piccolipiù birth cohort and the network of Pediatric Hospitals BURLO GAROFALO Ronfani Luca Clinico‐ Population Sciences and assistenzial Epidemiology e Social Sciences and Population Studies ‐ SSPS NET‐2013‐ 02358831‐3 Early risk factors of overweight and obesity in young children: the Piccolipiù birth cohort and the network of Pediatric Hospitals Lazio PORTA DANIELA Clinico‐ Population Sciences and assistenzial Epidemiology e Social Sciences and Population Studies ‐ SSPS Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 162 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO NET‐2013‐ 02358831‐4 Early epigenetic markers of childhood diseases: the Piccolipiù birth cohort and the network of Pediatric Hospitals Piemonte Richiardi Lorenzo Clinico‐ Population Sciences and assistenzial Epidemiology e Social Sciences and Population Studies ‐ SSPS NET‐2013‐ 02358831‐5 Communication strategies to parents for evidence‐based preventive practices in childhood: the Piccolipiù birth cohort and the network of Pediatric Hospitals OSPEDALE BAMBINO GESU' Bozzola Elena Clinico‐ Population Sciences and assistenzial Epidemiology e Social Sciences and Population Studies ‐ SSPS NET‐2013‐ 02359419‐1 Modeling current perinatal and neonatal data to predict infant outcomes and provide tools for measuring and improving quality of care Lombardia zanini rinaldo Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD NET‐2013‐ 02359419‐2 Magnesium Sulphate to prevent neurologic damage following preterm birth Lombardia FERRAZZI ENIRCO M. Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD NET‐2013‐ 02359419‐3 Ultrasound accuracy in assessing cerebellar haemorrhages in Very Low Birth Weight infants Liguria ramenghi luca antonio Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD NET‐2013‐ Area‐based Emilia Romagna Neonatal Network: outcome Emilia‐Romagna 02359419‐4 of VLBW infants at two years FERRARI FABRIZIO Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD NET‐2013‐ 02359419‐5 Prospective longitudinal approach to the small fetus: how Piemonte different patterns of fetal growth impact on neonatal morbidity and auxological, neurodevelopmental and metabolic outcomes at 2 years of corrected age. Bertino Enrico Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD NET‐2013‐ 02359663‐1 The emergency‐urgency network rationalization and the development of a disease management manual Lombardia Agostoni Elio Clemente Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD Friuli‐Venezia Giulia Eleopra Roberto Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD NET‐2013‐ The Hub and Spoke process for the endovascular 02359663‐2 treatment of acute ischaemic stroke DESTINATARIO ISTITUZIONALE Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 163 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE NET‐2013‐ The use of telestroke system to improve acute stroke care 02359663‐3 Veneto AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Giometto Bruno Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD PE‐2013‐ 02354800 Exendin‐4 improves insulin signaling in peripheral target Calabria tissues by modulating inflammatorypathways. Sesti Giorgio Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular Aspects of Diabetes and Obesity ‐ CADO PE‐2013‐ 02354821 Clustering of Autism Genetic, Epigenetic, and Functional MEDEA Connectivity data in a multidimensional space. Giorda Roberto Biomedica Biobehavioral and Behavioral Processes Child Psychopathology and Developmental Disabilities ‐ CPDD PE‐2013‐ 02354871 Mesenchymal Stem Cells and photoactivable Nanoparticles: a novel Anticancer Phototherapy System for High grade Osteosarcoma Treatment (SNAPSHOT) RIZZOLI DONATI DAVIDE MARIA Biomedica Oncology 2 ‐ Translational Clinical Developmental Therapeutics ‐ DT PE‐2013‐ 02354918 Graft function amelioration of organs from non heart beating donors by ex vivo perfusion withthe new oxygen carrier Hemarina‐M101 (HEMO2Life®). SAN MATTEO PELLEGRINI CARLO Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma ‐ SAT PE‐2013‐ 02354920 Definition and Prevalence of subclinical REM Sleep Behavior Disorder among Patients Attending Sleep Disorders Centers Associazione Oasi Maria SS Ferri Raffaele Biomedica Brain Disorders and Clinical Neuroscience Neural Basis of Psychopathology, Addictions and Sleep Disorders ‐ NPAS PE‐2013‐ 02354923 ISTITUTO TUMORI Osteopontin regulation of B‐cell lymphomagenesis, under chronic antigenic stimulation, models diffuse large MILANO B‐cell lymphoma . Mario Paolo Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME PE‐2013‐ 02354934 Understanding the role of TM9SF4 in the malignant progression of skin cancers. Preclinical studies on a new biomarker associated with drug resistance and invasiveness of melanoma cells Istituto Superiore di Sanita' Lozupone Francesco Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC PE‐2013‐ 02354961 Role of lipid rafts in the immune response to fungal infections. Istituto Superiore di Sanita' Gagliardi Maria Cristina Biomedica Immunology Immunity and Host Defense ‐ IHD Colombo Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 164 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE PE‐2013‐ 02354966 Imaging of systemic molecular events during mammary tumorigenesis as a novel approach for the identification of new clinically useful tumour biomarkers. REGINA ELENA Piaggio Giulia Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS PE‐2013‐ 02354980 Targeting the Syndecan‐1/ADAM10‐driven angiogenic pathway in solid tumors. IRCCS AOU San Martino‐ IST (Genova) Carnemolla Maria Barbara Biomedica Oncology 1 ‐ Basic Translational Tumor Progression and Metastasis ‐ TPM2 PE‐2013‐ 02354998 TNFalpha/CCL2/estrogen receptor axis in the Istituto Superiore di Sanita' Gessani pathogenesis and therapy of inflammatory bowel diseases Sandra Biomedica Immunology Innate Immunity And Inflammation ‐ III PE‐2013‐ 02355016 Type I IFN‐induced alteration of the vitamin D system: a mechanistic insight into interferonopathies Istituto Superiore di Sanita' Gauzzi Maria Cristina Biomedica Cell Biology Cellular Signaling and Regulatory Systems ‐ CSRS PE‐2013‐ 02355037 A research platform for development of miRNA‐based therapeutic strategies against multiple myeloma Calabria Tassone Pierfrancesco Biomedica Oncology 2 ‐ Translational Clinical Developmental Therapeutics ‐ DT PE‐2013‐ 02355069 Veneto ROLE OF ß‐CATENIN SIGNALING IN PROMOTING MACROPHAGE‐DRIVEN INFLAMMATION AND FIBROSIS IN FIBROCYSTIN‐DEFECTIVE LIVER DISEASE Fabris Luca Biomedica Cell Biology Intercellular Interactions ‐ ICI PE‐2013‐ 02355086 Identification of disease biomarkers and innovative therapeutic options for hereditary neuropathies Schenone Angelo Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Glia ‐ CMBG PE‐2013‐ 02355126 Homer‐mGlu5 scaffold as common abnormal mechanism Associazione Oasi Maria SS Catania and therapeutic target for Intellectual Disability (ID) and Autism Spectrum Disorders (ASD) Maria Vincenza Biomedica Molecular, Cellular, and Developmental Neuroscience Molecular Neuropharmacology and Signaling ‐ MNPS PE‐2013‐ 02355127 ANTIBODIES IN SINGLE‐CHAIN FORMAT AGAINST THE E6 AND E7 ONCOPROTEINS AS A NEW TREATMENT FOR THE HPV‐ASSOCIATED DISEASES Istituto Superiore di Sanita' Accardi PE‐2013‐ 02355133 Role of Che‐1 in multiple myeloma cell growth and progression REGINA ELENA IRCCS AOU San Martino‐ IST (Genova) Fanciulli Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Luisa Biomedica Oncology 2 ‐ Translational Clinical Developmental Therapeutics ‐ DT Maurizio Biomedica Cell Biology Cellular Signaling and Regulatory Systems ‐ CSRS Pagina 165 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE PE‐2013‐ 02355204 Leukocyte telomere length (LTL), mitochondrial DNA (mtDNA) copy number and multiple myeloma (MM) susceptibility and survival. Toscana Buda Gabriele Biomedica Population Sciences and Epidemiology Epidemiology of Cancer ‐ EPIC PE‐2013‐ 02355206 Novel pathways in PNS myelination and remyelination SAN RAFFAELE MILANO Taveggia Carla Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Glia ‐ CMBG PE‐2013‐ 02355229 Molecular determinants of muscle pericytes dysfunction in diabetes mellitus MULTIMEDICA Spinetti Gaia Biomedica Vascular and Hematology Vascular Cell and Molecular Biology ‐ VCMB PE‐2013‐ 02355271 Targeting oncogenic epigenetic factors as an innovative anticancer strategy in Rhabdomyosarcoma OSPEDALE BAMBINO GESU' Rota Rossella Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP PE‐2013‐ 02355346 Hematopoietic stem cell transplantation for malignant forms of Multiple Sclerosis. Toscana riccardo saccardi Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroimmunology and Brain Tumors ‐ CNBT PE‐2013‐ 02355362 OSTEOCHONDRAL SCAFFOLD FUNCTIONALISATION RIZZOLI BY BIOCOMPETENT DENDRONS Giavaresi Gianluca Biomedica Musculoskeletal, Oral and Skin Sciences Musculoskeletal Tissue Engineering ‐ MTE PE‐2013‐ 02355372 Brain Mechanisms of Chronic Subjective Dizziness SANTA LUCIA Indovina Iole Biomedica Integrative, Functional, and Cognitive Neuroscience Auditory System ‐ AUD PE‐2013‐ 02355374 Restoring the enteric nervous system: neural progenitors derived from Amniotic Fluid and Placenta Stem Cells for novel approaches in the treatment of Hirschsprung's disease and intestinal dysganglionosis Veneto Giacomello Luca Biomedica Biology of Development and Aging Cellular Mechanisms in Aging and Development ‐ CMAD PE‐2013‐ 02355472 From monogenic forms of Crohn¿s Disease to novel models for developing non‐immunosuppressive treatments. BURLO GAROFALO BIANCO ANNA MONICA ROSARIA Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Gastrointestinal Mucosal Pathobiology ‐ GMPB Pagina 166 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE PE‐2013‐ 02355484 Impact of carotid endarterectomy and stenting on hemodynamics, fluid‐structure interaction, autonomic modulation, and cognitive brain function. SAN RAFFAELE MILANO Marrocco Trischitta Massimiliano Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Bioengineering, Technology, and Surgical Sciences ‐ BTSS PE‐2013‐ 02355502 New molecular biomarkers and therapeutic targets in urologic cancers Calabria Belfiore Antonino Biomedica Oncology 1 ‐ Basic Translational Tumor Progression and Metastasis ‐ TPM2 PE‐2013‐ 02355527 NEW ANTI‐HCV VACCINES BASED ON ENGINEERED EXOSOMES Istituto Superiore di Sanita' ruggieri anna Biomedica Immunology Vaccines Against Microbial Diseases ‐ VMD PE‐2013‐ 02355575 Markers of prediction of sorafenib sensitivity in primary liver carcinoma HUMANITAS RONCALLI MASSIMO Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS PE‐2013‐ 02355589 Human experimental models for preclinical validation of exemestane in the treatment of mesothelioma and to identify novel biomarkers involved in drug response REGINA ELENA Galati Rossella Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS PE‐2013‐ 02355725 Role of the Association between Oxidative stress, Inflammation and Innate Immune System Response in the Survival and Function of Pancreatic Beta Cells SAN RAFFAELE PISANA DELLA MORTE DAVID Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular Aspects of Diabetes and Obesity ‐ CADO PE‐2013‐ 02355752 Evaluation of antitumor activity of claudin3‐specific immunotoxin in the treatment of recurrent chemotherapy resistant ovarian and uterine cancers. Lombardia RAVAGGI ANTONELLA Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII PE‐2013‐ 02355774 Liguria Identification of a prognostic miRNA signature in HG‐ PIN and development of artificial therapeutic miRNAs to prevent prostate cancer progression. Campodonico Fabio Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS PE‐2013‐ 02355826 Nutrient Stress and Epigenetic Control of HIV‐1 Gene Expression Poli Guido Biomedica AIDS and Related Research AIDS Immunology and Pathogenesis ‐ AIP PE‐2013‐ 02355869 An INTERvention programme to increase the QUALity of I.N.R.C.A. long‐term care facilities ‐ the INTERQUAL project Chiatti Carlos Clinico‐ Healthcare Delivery and assistenzial Methodologies e SAN RAFFAELE MILANO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Health Services Organization and Delivery ‐ HSOD Pagina 167 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE PE‐2013‐ 02355924 Integration of Transcriptomics and Next Generation Exome Sequencing to Identify Risk Variants in IgA Nephropathy Puglia COX SHARON NATASHA Biomedica PE‐2013‐ 02355948 High‐end and Low‐End Virtual Reality Systems for the Rehabilitation of Friality in the Elderly AUXOLOGICO Riva Giuseppe Clinico‐ Emerging Technologies and Brain Disorders and assistenzial Training in Neurosciences Related e Neurosciences Fellowship ‐ F01 PE‐2013‐ 02355951 Development of a novel immunotherapeutic approach in OSPEDALE BAMBINO type 1 diabetes and autoimmune polyendocrine syndrome GESU' type 3 variant: use of antisense oligonucleotides to PTPN22 gene variant conjugated to immunoliposomes Fierabracci Alessandra Clinico‐ Immunology assistenzial e Hypersensitivity, Autoimmune, and Immune PE‐2013‐ 02356021 Functional characterization of non‐coding regulatory elements controlling SOX factors expression in melanoma patients ARCISPEDALE Sancisi Valentina Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP PE‐2013‐ 02356078 Dravet syndrome: Effect of seizures on the severity of epileptic and cognitive phenotypes in a mouse model CARLO BESTA Scalmani Paolo Biomedica Brain Disorders and Clinical Neuroscience Acute Neural Injury and Epilepsy ‐ ANIE PE‐2013‐ 02356080 Multidimensional Approach in Geriatric Oncology Emilia‐Romagna (MAGO) study: optimising surgical outcomes in frail older adults affected by cancer. Ugolini Giampaolo Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC PE‐2013‐ 02356114 Leptin as novel therapeutic tool to control Mycobacterium tuberculosis infection via metabolic manipulation Carla Biomedica Infectious Diseases and Microbiology Host Interactions with Bacterial Pathogens ‐ HIBP PE‐2013‐ 02356137 Preclinical development of a new fenretinide formulation Istituto Superiore di Sanita' Pegna Zeuner Ann with high bioavailability and activity against cancer stem cells Biomedica Oncology 2 ‐ Translational Clinical Developmental Therapeutics ‐ DT PE‐2013‐ 02356195 Rescuing T‐cell dysfunction in Chronic Lymphocytic Leukemia by targeting the Notch signaling pathway Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME Istituto Superiore di Sanita' Palma Istituto Superiore di Sanita' Fedele Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Giorgio Classificazione 1 Liv. Classificazione 2° liv. Digestive, Kidney and Urological Systems Cellular and Molecular Biology of the Kidney ‐ CMBK Pagina 168 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE PE‐2013‐ 02356214 NOVEL TOOLS TO STUDY AND INHIBIT MALARIA PARASITES HOMING TO HUMAN BONE MARROW Istituto Superiore di Sanita' Silvestrini PE‐2013‐ 02356244 Role of the atypical chemokine receptor ACKR2 expressed by lymphatic vessels in metastatic colonization HUMANITAS PE‐2013‐ 02356282 Prospective, Randomized, Multi‐Center Trial of Lateral MAGGIORE Trendelenburg versus Semi‐ Recumbent Body Position in Mechanically Ventilated Patients For The Prevention of Ventilator‐Associated Pneumonia PE‐2013‐ 02356284 Mechanistic studies on the interplay between short‐term starvation and T cell immunotherapy for neuroectodermal tumors PE‐2013‐ 02356295 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Francesco Biomedica Infectious Diseases and Microbiology Pathogenic Eukaryotes ‐ PTHE BONECCHI RAFFAELLA Biomedica Immunology Innate Immunity And Inflammation ‐ III Panigada Mauro Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS GASLINI Prigione Ignazia Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB The use of language in limb apraxia rehabilitation FATEBENEFRATELLI Manenti Rosa Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN PE‐2013‐ 02356329 Identification of mechanisms underlying clinical heterogeneity in Phelan‐McDermid syndrome through detailed genotype/phenotype correlation, gene expression analysis, and system biology approaches MEDEA Bonaglia Maria Clara Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD PE‐2013‐ 02356335 Lysosomal‐mediated cellular clearance as a new strategy for the therapy of inherited demyelinating neuropathies SAN RAFFAELE MILANO Bolino Alessandra Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Glia ‐ CMBG PE‐2013‐ 02356364 PHARMACOEPIGENETICS IN SKIN WOUND REPAIR: IMPLICATIONS FOR CHRONIC ULCER TREATMENT ISTITUTO DERMOPATICO DELL'IMMACOLATA Napolitano Monica Biomedica Cardiovascular and Respiratory Sciences Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR PE‐2013‐ 02356398 Unraveling the role of GLUL in the susceptibility to coronary heart disease specifically affecting type 2 diabetes CASA SOLLIEVO SOFFERENZA Trischitta Vincenzo Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 169 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE PE‐2013‐ 02356431 Are microRNAs‐34 involved in mood disorders and in the SANTA LUCIA response to pharmacological treatments? Ventura Rossella Biomedica Brain Disorders and Clinical Neuroscience Pathophysiological Basis of Mental Disorders and Addictions ‐ PMDA PE‐2013‐ 02356451 Non‐coding DNA will fill the gaps in diagnostic and prognostic classifications of human leukemia. Umbria Di Giacomo Danika Biomedica Oncology 1 ‐ Basic Translational Cancer Genetics ‐ CG PE‐2013‐ 02356465 Evaluation of the diagnostic accuracy of three memory tests for early Alzheimer's disease Lombardia Clerici Francesca Maria Alessandra Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN PE‐2013‐ 02356613 Microfluidic organotypic model of monocyte GALEAZZI transendothelial migration to the joint for the screening of promising therapeutic strategies in obese osteoarthritic patients Lopa Silvia Biomedica Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ‐ ACTS PE‐2013‐ 02356626 Cellular transporters role in the pathogenesis of chemotherapy‐induced peripheral neurotoxicity Lombardia Cavaletti Guido Angelo Biomedica Genes, Genomes and Genetics Genomics, Computational Biology and Technology ‐ GCAT PE‐2013‐ 02356661 Targeting persistent bacilli to fight tuberculosis Istituto Superiore di Sanita' Giannoni Federico Biomedica Infectious Diseases and Microbiology Drug Discovery and Mechanisms of Antimicrobial Resistance ‐ DDR PE‐2013‐ 02356670 Role of newly disclosed Vd1 T cells expressing Natural HUMANITAS Cytotoxicity Receptors in the homeostasis of gut associated lymphoid tissue and in the physiopathology of inflammatory bowel diseases and colon‐rectal cancer. MAVILIO DOMENICO Biomedica Immunology Innate Immunity And Inflammation ‐ III PE‐2013‐ 02356684 Clonal analysis of pancreatic ductal adenocarcinoma and related metastatic regional and at distance lymph nodes as an aid to stratify patients for personalized treatment. zerbi alessandro Biomedica Oncology 1 ‐ Basic Translational Cancer Genetics ‐ CG HUMANITAS Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 170 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE PE‐2013‐ 02356685 Implication of vitamin D in gestational hypertension and Sicilia preeclampsia. PE‐2013‐ 02356702 Clinical impact of three‐dimensional patient specific dosimetry with Monte Carlo simulations in Peptide Radionuclide Radiation Therapy. Basis for clinical protocols established on dosimetric/radiobiological parameters. PE‐2013‐ 02356818 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Santoro Domenico Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Endocrinology, Metabolism, Nutrition and Reproductive Sciences (EMNR) Integrated Review Group Fellowship Panel ‐ F06 I.E.O. CREMONESI MARTA Clinico‐ Healthcare Delivery and assistenzial Methodologies e Biostatistical Methods and Research Design ‐ BMRD Circulating microRNAs as biomarkers of chemotherapy‐ related cardiotoxicity and myocardial inflammation HUMANITAS CONDORELLI GIANLUIGI Biomedica Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF PE‐2013‐ 02356864 Identifying genes responsible for familial diabetes of the adulthood by next generation sequencing of the whole exome. CASA SOLLIEVO SOFFERENZA Prudente Sabrina Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD PE‐2013‐ 02356930 Genetic and early environmental determinants of methylation pattern in immune function genes: the contribution of singleton and twin birth cohorts. Istituto Superiore di Sanita' Stazi Maria Antonietta Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD PE‐2013‐ 02356940 Early development of locomotion in cerebral palsy children SANTA LUCIA Ivanenko Yury Biomedica Biology of Development and Aging Development‐2 ‐ DEV2 PE‐2013‐ 02356990 Joint dynamical HRV‐rsfMRI analysis: a new tool to investigate central correlates of ANS dysfunction in PD and Parkinsonisms. Toscana Tessa Carlo Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN PE‐2013‐ 02357094 Etiology and prevention of type 1 diabetes Lombardia Antonio Toniolo Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Clinical and Integrative Diabetes and Obesity ‐ CIDO Pagina 171 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE PE‐2013‐ 02357099 Maternal metabolic conditions in pregnancy and childhood obesity: mechanisms involved and disease burden in Italy Piemonte merletti franco Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Pregnancy and Neonatology ‐ PN PE‐2013‐ 02357264 Role of STAT3 signalling in control of muscle regeneration, growth and autophagy during age‐related degenerative neuromuscular diseases SANTA LUCIA Latella Lucia Biomedica Musculoskeletal, Oral and Skin Sciences Skeletal Muscle Biology and Exercise Physiology ‐ SMEP PE‐2013‐ 02357299 Functional interactions of HTLV‐1 proteins controlling oncogenic and inflammatory pathways I. O. V. Ciminale Vincenzo Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP PE‐2013‐ 02357338 Evaluation of drug metabolism and transporters (DMET)‐ Calabria related genetic polymorphisms in Multiple Myeloma (MM) patients undergoing high dose melphalan therapy Tagliaferri Pierosandro Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS PE‐2013‐ 02357374 From the estimate of HIV undiagnosed people to the control of viral load: the implementation of a network of clinical centres to assess the HIV cascade in Italy Istituto Superiore di Sanita' SULIGOI BARBARA Clinico‐ AIDS and Related Research assistenzial e AIDS Clinical Studies and Epidemiology ‐ ACE PE‐2013‐ 02357408 Harnessing T cell responses against leukemia with CD1c‐ restricted TCRs specific for self‐lipid antigens SAN RAFFAELE MILANO Casorati Giulia Biomedica Immunology Transplantation, Tolerance and Tumor Immunology ‐ TTT PE‐2013‐ 02357465 Human Papilloma Virus (HPV) Exploitation of the SUMO I.E.O. (Small Ubiquitin‐like MOdifier) Pathway in HPV‐ induced cancers. CHIOCCA SUSANNA Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC PE‐2013‐ 02357476 Circulating cell‐derived microvesicles in coronary artery disease: molecular signature, functional properties, and predictive value in coronary artery bypass graft patency Camera Marina Clinico‐ Vascular and Hematology assistenzial e Atherosclerosis and Inflammation of the Cardiovascular System ‐ AICS PE‐2013‐ 02357477 Application of Next Generation Sequencing (Ion Torrent) GASLINI for the molecular characterization of non autoimmune diabetes mellitus since newborn to young adult in patients with uncertain diagnosis d'Annunzio Giuseppe Clinico‐ Genes, Genomes and assistenzial Genetics e Genetics of Health and Disease ‐ GHD MONZINO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 172 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE Classificazione 1 Liv. Classificazione 2° liv. PE‐2013‐ 02357540 POTENTIAL BIOLOGICAL MARKERS AND MOLECULAR PROFILING OF HEPARAN SULFATES IN MO PATIENTS: EVALUATION OF PATHOPHYSIOLOGICAL PATHWAYS TO DEFINE A COMPLETE BIOCHEMICAL PROFILING FOR DIAGNOSIS AND PATIENTS FOLLOW‐UP RIZZOLI Locatelli Manuela Biomedica Genes, Genomes and Genetics Therapeutic Approaches to Genetic Diseases ‐ TAG PE‐2013‐ 02357550 Understanding the role of mesenchymal stromal cell‐ derived microvesicles in the inflammatory leukemic microenvironment OSPEDALE BAMBINO GESU' Bernardo Maria Ester Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME PE‐2013‐ 02357562 Istituto Scientifico Tridimensional biomimetic models to improve breast cancer in vitro studies: effect of the microenvironment on Romagnolo tumor behavior, hypoxia response and drug resistance Ibrahim Toni Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME PE‐2013‐ 02357623 Role of Opisthorchis felineus, an emerging human parasite in Italy, in the development of cholangiocarcinoma in an animal model of chronic infection. Istituto Superiore di Sanita' Pozio Edoardo Biomedica Infectious Diseases and Microbiology Pathogenic Eukaryotes ‐ PTHE PE‐2013‐ 02357632 Epigenetic, aging (leukocyte telomere length), inflammatory markers and geographical‐, sex‐ related differences in cardiovascular disease (the EPI‐AGING study). MONZINO Baldassarre Damiano Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS PE‐2013‐ 02357669 The oncogenic potential of the AID/APOBECs: involvement in tissue transformation and oncogenesis ‐ new tools to better model cancer Toscana Conticello Silvestro Biomedica Cancer Etiology ‐ CE PE‐2013‐ 02357684 REGINA ELENA Implementation of FOLFIRINOX in the routine management of pancreatic cancer patients: clinical impact of dose/schedule modifications and additional supportive measures and potential for pharmacogenetics‐ based strategies for treatment selection and person Milella Michele Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC PE‐2013‐ 02357688 The therapeutic potential of peroxisome proliferator‐ activated receptor PPAR gamma and its ligands as new targets against infection by lentiviruses alessandra Biomedica Immunity and Host Defense ‐ IHD Istituto Superiore di Sanita' borsetti Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Oncology 1 ‐ Basic Translational Immunology Pagina 173 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE PE‐2013‐ 02357700 REGINA ELENA BRAIN TUMOR‐RELATED EPILEPSY: AN UNCONVENTIONAL TREATMENT APPROACH BASED ON NEW KNOWLEDGE OF PATHOGENETIC MECHANISMS Maschio Marta Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT PE‐2013‐ 02357701 SYNCHRONIZATION of INHIBITION PRECEDES and PROMOTES EPILEPTIC SEIZURES CARLO BESTA de Curtis Marco Biomedica Brain Disorders and Clinical Neuroscience Acute Neural Injury and Epilepsy ‐ ANIE PE‐2013‐ 02357727 Multipotent Amniotic Fluid‐derived Stem Cells (AFS) may iinfluence Survival and Differentiation of Neuroblastoma Cells : a possible New Therapeutic Tool GASLINI Martucciello Giuseppe Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB PE‐2013‐ 02357745 Coagulation/complement activation and cerebral hypoperfusion in relapsing‐remitting multiple sclerosis REGINA ELENA Koudriavtseva Tatiana Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN PE‐2013‐ 02357747 IRCCS AOU San Martino‐ Structural proteomics and solution characterization of proteins of biomedical/oncological interest: development IST (Genova) of a comprehensive facility, application to the fibrin(ogen)‐integrins cell‐matrix interactions model system, and to the mechanism of fibrin fo Rocco Mattia Biomedica Biological Chemistry and Macromolecular Biophysics Macromolecular Structure and Function D ‐ MSFD PE‐2013‐ 02357780 Evaluation of immune‐reconstitution in patients given TCR‐alpha beta/B‐cell depleted haploidentical stem cell transplantation followed by the addback of donor T‐cells expressing an inducible Caspase9 suicide gene pagliara daria Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII PE‐2013‐ 02357792 I.E.O. Adipose tissue progenitors, angiogenesis and breast cancer metastasis‐initiating cells. Identification of targets and therapeutic interventions BERTOLINI FRANCESCO Biomedica Oncology 2 ‐ Translational Clinical Developmental Therapeutics ‐ DT PE‐2013‐ 02357806 ISTITUTO TUMORI Improving standard of care: translating molecular portrait into clinically effective tools to overcome ovarian MILANO cancer recurrence. Mezzanzanica Delia Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT OSPEDALE BAMBINO GESU' Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 174 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE PE‐2013‐ 02357823 Next generation sequencing of synchronous and metachronous hepatic colorectal cancer metastases to identify prognostic biomarkers and therapeutic targets Lazio Nigri Giuseppe Riccardo Biomedica PE‐2013‐ 02357826 Chronic Kidney Disease as a Dysmetabolic Determinant of Disability among Older People (CKD‐3D) I.N.R.C.A. Corsonello Andrea Clinico‐ Population Sciences and assistenzial Epidemiology e Kidney, Nutrition, Obesity and Diabetes ‐ KNOD PE‐2013‐ 02357871 REGULATION of IMMUNITY in PATIENTS UNDERGOING ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION Emilia‐Romagna Arpinati Mario Biomedica Immunology Transplantation, Tolerance and Tumor Immunology ‐ TTT PE‐2013‐ 02357883 Systemic safety of antiangiogenic therapy for intravitreal use in retinal vascular disease: systematic review and network meta‐analysis Toscana Virgili Gianni Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD PE‐2013‐ 02357925 Role of hypoxia induced non‐coding RNAs in peripheral ischemia SAN DONATO Martelli Fabio Biomedica Vascular Cell and Molecular Biology ‐ VCMB PE‐2013‐ 02357936 A registry of severe malaria in returning travellers from endemic countries: clinical outcome and adverse events including haematological and pharmacokinetic data. NetwOrk for severe MALaria treatment ‐ NOMAL study SPALLANZANI Nicastri Emanuele Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS PE‐2013‐ 02357974 Virtual and Augmented Reality Support for Transcatheter Toscana Valve Implantation by usingCardiovascular MRI Positano Vincenzo Biomedica Biomedical Imaging Technology ‐ BMIT PE‐2013‐ 02357980 Does intensive exercise induce plasticity‐related changes in Parkinson's Disease? NEUROLESI Russo Margherita Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN PE‐2013‐ 02358045 Development of stem cell‐derived METABO‐MIMETIC nanovesicleS as new therapeutic approach to inflammation and cancer(METABO‐MIMETICS) SAN RAFFAELE MILANO Drago Denise Biomedica Gene and Drug Delivery Systems ‐ GDD Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Oncology 1 ‐ Basic Translational Vascular and Hematology Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering Sciences and Technologies Classificazione 2° liv. Tumor Progression and Metastasis ‐ TPM2 Pagina 175 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO PE‐2013‐ 02358053 A computer based tool for real time classification of colorectal lesions detected by endoscopy PE‐2013‐ 02358085 DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Granata Antonino Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Computational modeling and sciences for biomedical and clinical applications ‐ ZRCM Neuroblastoma prognostic biomarkers in primary tumors GASLINI and blood exosomes Varesio Luigi Biomedica Oncology 1 ‐ Basic Translational Tumor Progression and Metastasis ‐ TPM2 PE‐2013‐ 02358099 Reduction of breast cancer recurrence in women: lifestyle PASCALE strategies and microRNA expression Montella Maurizio Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Chemo/Dietary Prevention ‐ CDP PE‐2013‐ 02358104 Identification of new genes involved in the myelomagenesis and their validation as new therapeutic targets in multiple myeloma GIULIANI NICOLA Biomedica Molecular Oncogenesis ‐ MONC PE‐2013‐ 02358107 Opioid tolerance in chronic pain patients: understanding SAN RAFFAELE PISANA the molecular mechanism for a new therapeutic approach Muscoli Carolina Clinico‐ Integrative, Functional, assistenzial and Cognitive Neuroscience e Somatosensory and Chemosensory Systems ‐ SCS PE‐2013‐ 02358116 Gastrointestinal (GI) disorders associated to ASDs: investigating their clinical characteristics and geneticsusceptibility along the brain‐gut axis Emilia‐Romagna Parmeggiani Antonia Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD PE‐2013‐ 02358119 Targeting the tumor‐stroma crosstalk to restrain breast cancer recurrence. A translational approach: from bedside to bench and back C.R.O. AVIANO Belletti Barbara Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB PE‐2013‐ 02358145 Clinical, structural and functional markers for recovery of MAUGERI consciousness Estraneo Anna Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN PE‐2013‐ 02358146 The E. coli cytotoxic necrotizing factor 1 as a new drug for OSPEDALE BAMBINO GESU' counteracting energetic defects in mitochondrial disorders: a preclinical study. Rizza teresa Biomedica Developmental Brain Disorders ‐ DBD Sicilia Emilia‐Romagna Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Oncology 1 ‐ Basic Translational Brain Disorders and Clinical Neuroscience Pagina 176 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE PE‐2013‐ 02358174 ROLE OF ROTAVIRUS INFECTION IN THE PATHOGENESIS OF CELIAC DISEASE Istituto Superiore di Sanita' Silano PE‐2013‐ 02358199 Genetic determinants of Trousseau Syndrome Lazio PE‐2013‐ 02358228 Bringing exposomics into systems medicine: Study of the SAN RAFFAELE PISANA occupational and environmental determinants of COPD PE‐2013‐ 02358240 Childhood apraxia of speech: neurobiological and behavioural markers and experience‐dependent changes of neural connectivity induced by treatment. STELLA MARIS PE‐2013‐ 02358393 PREDICTING THE FUTURE HEALTH CARE NEEDS OF CANCER SURVIVORS IN AGEING POPULATIONS (FORECARE) Istituto Superiore di Sanita' De Angelis PE‐2013‐ 02358414 Small‐molecule quadruplex‐targeted drug discovery for a REGINA ELENA multimodal therapy against colorectal tumor: Towards Clinical candidate selections PE‐2013‐ 02358439 Dissecting the role of microRNAs in the radiation response of human prostate cancer PE‐2013‐ 02358444 PE‐2013‐ 02358462 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Marco Biomedica Digestive, Kidney and Urological Systems Gastrointestinal Mucosal Pathobiology ‐ GMPB Mango Ruggiero Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD BONASSI STEFANO AURELIO Clinico‐ Population Sciences and assistenzial Epidemiology e Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions ‐ IRAP Chilosi Anna Biomedica Developmental Brain Disorders ‐ DBD Roberta Clinico‐ Population Sciences and assistenzial Epidemiology e Epidemiology of Cancer ‐ EPIC Biroccio Annamaria Biomedica Cell Biology Cellular Signaling and Regulatory Systems ‐ CSRS Zaffaroni Nadia Biomedica Oncology 2 ‐ Translational Clinical Radiation Therapeutics and Biology ‐ RTB Advanced diffusion MRI methods to improve detection CARLO BESTA and characterization of focal cortical dysplasias in surgically‐remediable epileptic patients: an in vivo and ex vivo study with neuropathological correlation Zucca Ileana Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Medical Imaging ‐ MEDI ADAR2‐mediated miR‐editing as a novel therapeutic tool OSPEDALE BAMBINO for glioblastoma therapy GESU' Gallo Angela Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP ISTITUTO TUMORI MILANO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Brain Disorders and Clinical Neuroscience Pagina 177 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE PE‐2013‐ 02358469 IDENTIFICATION OF DIETARY‐ASSOCIATED BIOMARKERS FOR THE PREVENTION OF CERVICAL CANCER THROUGH INTEGRATIVE AND EPIGENETIC APPROACHES PE‐2013‐ 02358471 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Antonella Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP Host‐Hepatitis C virus interaction in different geographic Istituto Superiore di Sanita' ciccozzi areas: disease progression and resistance markers massimo Biomedica Immunology Immunity and Host Defense ‐ IHD PE‐2013‐ 02358481 Identification of reliable lipid markers associated with prostate cancer and evaluation of autophagy and Myc modulators as possible pharmacological tools to affect lipid profiling and prostate cancer phenotype. PASCALE pucci biagio Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB PE‐2013‐ 02358567 New Insights in the Etiology and Pathophysiology of Early‐Life Functional Gastrointestinal Disorders: role of Microbiome and Environmental Factors. Campania Miele Erasmo Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Clinical, Integrative and Molecular Gastroenterology ‐ CIMG PE‐2013‐ 02358576 Novel genomic biomarkers potentially useful in REGINA ELENA informing treatment decisions and in predicting drug toxicity: a retrospective and prospective study in Luminal B breast cancer patients Cognetti Francesco Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS PE‐2013‐ 02358577 Analysis of NLRP3 inflammasome as important new therapeutic target in neurodegenerative diseases SANTA LUCIA Ciaramella Antonio Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT PE‐2013‐ 02358590 Cellular vectors to maximize the delivery of standard chemotherapeutics to lung cancer SDN Parodi Alessandro Biomedica Bioengineering Sciences and Technologies Gene and Drug Delivery Systems ‐ GDD PE‐2013‐ 02358650 Influence of steatosis, intracellular lipid accumulation and lipophagy on the efficacy of the HCV NS5B polymerase inhibitor SPALLANZANI Montalbano Marzia Clinico‐ Infectious Diseases and assistenzial Microbiology e Sicilia Agodi Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Clinical Research and Field Studies of Infectious Diseases ‐ CRFS Pagina 178 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE PE‐2013‐ 02358658 Interplay between cAMP and RhoA pathways with filamin A: effects on pituitary tumors invasiveness and response to drugs MAGGIORE Mantovani Giovanna Biomedica PE‐2013‐ 02358717 EFFECTS OF INFUSIONAL LEVODOPA CARBIDOPA THERAPY ON GAIT, FALLS AND POSTURAL INSTABILITY IN ADVANCED PARKINSON¿S DISEASE Emilia‐Romagna sensi mariachiara Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN PE‐2013‐ 02358742 Development of vaccines to control salmonellosis using attenuated strains with altered metaluptake capability IZSLER Alborali Giovanni Loris Biomedica Veterinary Animal Health ‐ ANHE PE‐2013‐ 02358815 The function of Group I metabotropic glutamate receptor NEUROMED subtypes in absence epilepsy Ngomba Richard Teke Biomedica Brain Disorders and Clinical Neuroscience Acute Neural Injury and Epilepsy ‐ ANIE PE‐2013‐ 02358850 The use of cell migration modulators as a novel approach Istituto Superiore di Sanita' Vendetti to enhance vaccine‐induced immunity in immune‐ compromised hosts Silvia Biomedica Immunology Vaccines Against Microbial Diseases ‐ VMD PE‐2013‐ 02358866 SIGNATURES OF VOLITIONAL INHIBITION IN THE SUBTHALAMIC NUCLEUS: A ROAD FOR OPTIMIZING DEEP BRAIN STIMULATION PLACEMENT Giovanni Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN PE‐2013‐ 02358887 Pancreatic ductal adenocarcinoma (PDAC): development SAN MATTEO of a new communication platform between radiologists, surgeons and pathologists based on virtual and 3D printed reconstructions of the pancreas and the tumor mass. PIETRABISSA ANDREA Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Computational modeling and sciences for biomedical and clinical applications ‐ ZRCM PE‐2013‐ 02358957 Prevention of human adverse health effects of endocrine active substances: evaluation of the quality of individual epidemiological studies, and quantitative assessment of the impact based on the overall toxicological and mechanistic data combined with epi Lombardia moretto angelo Biomedica Healthcare Delivery and Methodologies Biostatistical Methods and Research Design ‐ BMRD PE‐2013‐ 02358965 Methods and tools to monitor trends in HIV epidemic and the impact of preventive programs. SPALLANZANI Ippolito Giuseppe Clinico‐ AIDS and Related Research assistenzial e NEUROMED Mirabella Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Endocrinology, Metabolism, Nutrition and Reproductive Sciences Molecular and Cellular Endocrinology ‐ MCE AIDS Clinical Studies and Epidemiology ‐ ACE Pagina 179 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE PE‐2013‐ 02358976 Toscana The role of neutrophil extracellular traps in rheumatoid arthritis: new pathogenetic mechanisms and novel targets for diagnosis and therapy PE‐2013‐ 02359008 Genetic dissection and functional characterization of a neuronal plasma membrane Ca2+ atpase in the pathogenesis of congenital ataxia PE‐2013‐ 02359028 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. migliorini paola Biomedica Immunology Hypersensitivity, Autoimmune, and Immune Zanni Ginevra Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD MAUGERI Sensory and autonomic markers in early diagnosis of parkinsonism. A new strategy to predict clinical evolution toward different neruodegenerative disorders. Nolano Maria Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN PE‐2013‐ 02359039 Influenza A Virus Evolution and Adaptation to Host Restriction Factors SAN RAFFAELE MILANO Vicenzi Elisa Biomedica Virology A and B Study Sections ‐ VIRA and VIRB PE‐2013‐ 02359040 Vascular Cognitive Decline in Atrial Fibrillation: Advanced MRI neuroimaging and in‐depth neuropsychological assessment of brain damage an dysfunction CARLO BESTA Boffano Carlo Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN PE‐2013‐ 02359116 Understanding the role of intracellular zinc regulation in endothelial and cardiac cellular senescence I.N.R.C.A. Malavolta Marco Biomedica Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF PE‐2013‐ 02359129 Characterization of neurovascular coupling and brain functional response to hypoglycemia in Type 1 diabetes SANTA LUCIA Giove Federico Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative Physiology of Obesity and Diabetes ‐ IPOD PE‐2013‐ 02359172 Development and pre‐clinical validation of a soft‐ tethered endoscopic robot to replace colonoscopy as a screening tool for colorectal cancer Piemonte AREZZO ALBERTO Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences ‐ BTSS OSPEDALE BAMBINO GESU' Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Infectious Diseases and Microbiology Pagina 180 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE PE‐2013‐ 02359184 Innovative humanized mouse models for fast tracking the SAN RAFFAELE MILANO clinical translation of CAR T cells Bondanza Attilio Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII PE‐2013‐ 02359192 The Linosa Project: a whole‐island study on atypical hemolytic uremic syndrome Lombardia SCOLARI FRANCESCO Biomedica Digestive, Kidney and Urological Systems Pathobiology of Kidney Disease ‐ PBKD PE‐2013‐ 02359201 Statistical model for breast cancer screening integrating individual risk factors: a cost effectiveness analysis. Toscana Ventura Leonardo Biomedica Healthcare Delivery and Methodologies Biomedical Computing and Health Informatics ‐ BCHI PE‐2013‐ 02359254 Altered VAPB‐dependent lipid metabolism investigated in novel cell models for ALS CARLO BESTA Bernasconi Pia Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND PE‐2013‐ 02359287 Structural biomarkers of awareness and wakefulness in disorders of consciousness CARLO BESTA Ferraro Stefania Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN PE‐2013‐ 02359379 An immunogenomic Therapy for Multiple Myeloma C.R.O. AVIANO Michieli Mariagrazia Biomedica Oncology 2 ‐ Translational Clinical Developmental Therapeutics ‐ DT PE‐2013‐ 02359389 Human intestinal organoids for new therapies Campania GRECO LUIGI Biomedica Bioengineering Sciences and Technologies Modeling and Analysis of Biological Systems ‐ MABS PE‐2013‐ 02359471 New strategies for diagnosis and rehabilitation of impaired bodily self recognition in neurological patients with motor deficit following cerebro‐vascular and degenerative disease MAUGERI Frassinetti Francesca Biomedica Integrative, Functional, and Cognitive Neuroscience Cognitive Neuroscience ‐ COG PE‐2013‐ 02359574 In vivo assessment of the role of Locus Coeruleus in the development of Alzheimer's Disease and other types of Dementia. Toscana Giorgi Filippo Sean Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Clinical Neuroscience and Neurodegeneration ‐ CNN Pagina 181 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE PE‐2013‐ 02359619 Dysregulation of glycogen synthase kinase 3 signaling in mood disorders: identification of new molecular targets, prognostic and response biomarkers. Lazio JANIRI LUIGI Biomedica Brain Disorders and Clinical Neuroscience Pathophysiological Basis of Mental Disorders and Addictions ‐ PMDA PE‐2013‐ 02359734 Endogenous Reverse Transcriptase as early diagnostic biomarker of cancer progression and as potential target for innovative differentiation cancer treatment SAN RAFFAELE PISANA GUADAGNI FIORELLA Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS PE‐2013‐ 02359750 Intrabody‐mediated prion ablation as a novel gene‐based SAN RAFFAELE PISANA antibody strategy against Alzheimer's disease CARDINALE ALESSIO Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN PE‐2013‐ 02359759 Integrated analysis of circulating and intramuscular SANTA LUCIA myogenic micro‐RNA as biomarker of disease progression and response to pharmacological treatment in Duchenne Muscular Dystrophy patients. Saccone Valentina Biomedica Musculoskeletal, Oral and Skin Sciences Skeletal Muscle Biology and Exercise Physiology ‐ SMEP RF‐2013‐ 02354798 Characterization of the molecular mechanisms allowing Neuroblastoma cells to suppress immune surveillance and set up of biotherapeutic approaches capable to counteract their effects. Bottino Cristina Biomedica Immunology Transplantation, Tolerance and Tumor Immunology ‐ TTT RF‐2013‐ 02354819 Istituto Superiore di Sanita' Rosi Metabolic profiling of cancer stem‐like cells from glioblastoma patients: 1H NMR spectroscopic fingerprints coupled to biological, radiobiological and clinical data. Antonella Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02354829 Seven Tesla MR imaging as preclinical biomarker in populations at risk for Parkinson disease Cosottini Mirco Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02354830 Metabolomic profile of the amniotic fluid collected Veneto during amniocentesis in the second trimester of gestation: predictability for renal and respiratory diseases in infancy Zaffanello Marco Biomedica Pregnancy and Neonatology ‐ PN GASLINI Toscana Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Endocrinology, Metabolism, Nutrition and Reproductive Sciences Pagina 182 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02354832 Targeting epigenetic regulation of pro‐angiogenic factors Veneto in malignant gliomas Cabrini Giulio Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT RF‐2013‐ 02354834 Development of innovative in vitro infection models, Veneto based on human cell reprogramming and gene editing, to investigate the biology and pathogenesis of neurotropic viruses and to test new antiviral molecules. Barzon Luisa Biomedica Infectious Diseases and Microbiology Virology A and B Study Sections ‐ VIRA and VIRB RF‐2013‐ 02354835 COMPARATIVE EFFICACY OF OMOLOGOUS BLOOD‐ BASED EYEDROPS FROM DIFFERENT SOURCES IN THE TREATMENT OF SEVERE KERATOPATHY ‐ A RANDOMIZED CLINICAL TRIAL Velati Claudio Vittorio Clinico‐ Vascular and Hematology Hematology Small Business Activities ‐ SBIR/STTR ‐ SBHE RF‐2013‐ 02354850 Genome‐based development of new diagnostic, virulence Emilia‐Romagna and epidemiological markers for nontuberculous mycobacteria RUMPIANESI FABIO Biomedica Infectious Diseases and Microbiology Clinical Research and Field Studies of Infectious Diseases ‐ CRFS RF‐2013‐ 02354852 Humoral and functional characterization of extracellular ncRNAs in pathogenesis of Myotonic Dystrophy type 1 SAN DONATO GRECO SIMONA Biomedica Musculoskeletal, Oral and Skin Sciences Skeletal Muscle Biology and Exercise Physiology ‐ SMEP RF‐2013‐ 02354859 Q‐fever in Italy: pilot study to investigate presence, diffusion and genetic diversity of Coxiella burnetii IZSAM Garofolo Giuliano Biomedica Genes, Genomes and Genetics Genetic Variation and Evolution ‐ GVE RF‐2013‐ 02354863 Lycopene, Selenium and Polydeoxyribonucleotide: a triple therapeutic approach in conditions of male infertility Sicilia Minutoli Letteria Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular, Molecular and Integrative Reproduction ‐ CMIR RF‐2013‐ 02354865 Emerging role of Torque Teno virus (TTV) in food chain IZSME Viscardi Maurizio Biomedica Veterinary Food Safety ‐ FOSA RF‐2013‐ 02354866 Role of glycosylation in Alzheimer's disease MARIO NEGRI Balducci Claudia Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN Emilia‐Romagna AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. assistenzial e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 183 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02354869 Early detection and prevention of subtle cognitive decline: neuropsychological and imaging signature of asymptomatic at‐risk adults RF‐2013‐ 02354873 Feasibility of network among Hospitals to provide a high IRCCS AOU San Martino‐ quality, cost effective fertility preservation with ovarian IST (Genova) tissue banking to girls and women undergoing gonadotoxic treatments. RF‐2013‐ 02354874 Seroprevalence of Hepatitis E virus infection in Italian blood donors: a survey at national and regional level Istituto Superiore di Sanita' Pisani RF‐2013‐ 02354876 Re‐organization of neural circuits before memory loss in mice models of Alzheimer¿s disease: experimental approach of the cognitive reserve concept and implications for diagnosis and therapy SANTA LUCIA RF‐2013‐ 02354879 ADOPTIVE IMMUNOTHERAPY FOR METASTATIC COLORECTAL CANCER PATIENTS RF‐2013‐ 02354880 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Piras Federica Biomedica Anserini Paola Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD Giulio Biomedica Population Sciences and Epidemiology Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions ‐ IRAP Ammassari‐ Teule Martine Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN Lombardia Bregni Marco Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII NSD1 PHD fingers as potential targets for Acute Myeloid Leukemia SAN RAFFAELE MILANO Musco Giovanna Biomedica Biological Chemistry and Macromolecular Biophysics Macromolecular Structure and Function C ‐ MSFC RF‐2013‐ 02354882 Alcohol‐ related neurodevelopmental disorders: prevention and early diagnosis of fetal alcohol spectrum disorders and fetal alcohol syndrome. Istituto Superiore di Sanita' Pichini Simona Biomedica Risk, Prevention and Health Behavior Risk, Prevention and Intervention for Addictions ‐ RPIA RF‐2013‐ 02354883 A molecular‐oriented approach as a selection tool for multimodal treatment of gastric cancer. Multicenter biomarker validation conducted by the Italian Research Group for Gastric Cancer (GIRCG) network Toscana DANIELE Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS SANTA LUCIA MARRELLI Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN Pagina 184 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02354884 APRON: Assay for PRiONs. DEVELOPMENT OF AN ASSAY DETECTING PRIONS IN ANIMALS AND HUMANS AFFECTED WITH PRION DISORDERS IN A PRECLINICAL AND CLINICAL STAGE IZSPLV Casalone Cristina Biomedica RF‐2013‐ 02354889 Adipose tissue‐related mechanisms and vascular dysfunction in different obese phenotypes. Lazio Tesauro Manfredi Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO RF‐2013‐ 02354891 Innovative strategies for osteochondral lesions treatment: RIZZOLI new stem cell sources and new biomimetic polymeric scaffold Torricelli Paola Biomedica Musculoskeletal, Oral and Skin Sciences Musculoskeletal Tissue Engineering ‐ MTE RF‐2013‐ 02354892 Pancreatic cancer therapy based on combination of DNA vaccination and PI3Kgammainhibition Piemonte Novelli Francesco Biomedica Immunology Transplantation, Tolerance and Tumor Immunology ‐ TTT RF‐2013‐ 02354894 Functional and molecular characterization of glutamate‐ dependent mechanisms regulating brain metabolism in Alzheimer's disease Marche Amoroso Salvatore Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN RF‐2013‐ 02354899 Targeted multiple dye‐doped NIR emitting silica nanoparticles as optical imaging probes for cancer diagnostic applications BURLO GAROFALO BIFFI STEFANIA Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Clinical Molecular Imaging and Probe Development ‐ CMIP RF‐2013‐ 02354900 Dissecting the molecular network of interleukin‐1ß in non‐alcoholic steatohepatitis in order to identify novel potential therapeutic targets OSPEDALE BAMBINO GESU' Alisi Anna Biomedica Digestive, Kidney and Urological Systems Hepatobiliary Pathophysiology ‐ HBPP RF‐2013‐ 02354903 Analysis of somatic mutations and related altered pathways for the identification ofnew biomarkers and molecular targets in tumors of the lower female genital tract PASCALE Tornesello Maria Lina Clinico‐ Genes, Genomes and assistenzial Genetics e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Veterinary Animal Health ‐ ANHE Genetics of Health and Disease ‐ GHD Pagina 185 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02354905 Investigating the molecular mechanisms leading to genome instability in tumours: analysis ofrole of the replication stress response and its potential for early diagnosis and target therapy of cancer Istituto Superiore di Sanita' Pichierri Pietro Biomedica RF‐2013‐ 02354906 Role of Extra virgin olive oil in modulating post‐prandial oxidative stress in Diabetic patients Lazio Pasquale Pignatelli Clinico‐ Risk, Prevention and assistenzial Health Behavior e Behavioral Medicine: Interventions and Outcomes ‐ BMIO RF‐2013‐ 02354908 A MULTICENTRE PHASE II RANDOMIZED STUDY OF REGINA ELENA FULVESTRANT VERSUS FULVESTRANT + METFORMIN AS FIRST‐ AND SECOND‐LINE ENDOCRINE TREATMENT IN NON DIABETIC POSTMENOPAUSAL WOMEN WITH HORMONE RECEPTOR POSITIVE, HER‐2 NEGATIVE ADVANCED BREAST CANCER. THE META TRIAL. Vici Patrizia Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC RF‐2013‐ 02354910 Signaling networks in cerebellar neurodegenerative disorders and cancer: role of Ataxia Telangiectasia Mutated (ATM) kinase SANTA LUCIA Barilà Daniela Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND RF‐2013‐ 02354911 Non Alcoholic Fatty Liver Disease (NAFLD), vitamin D and cardiometabolic risk: a proof of concept study Lombardia Belli Luca Saverio Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO RF‐2013‐ 02354912 MicroRNAs as a novel diagnostic biomarkers for Non Alcoholic Fatty Liver Disease (NAFLD) and Non Alcoholic SteatoHepatitis (NASH). Sicilia Purrello Francesco Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Molecular and Cellular Endocrinology ‐ MCE RF‐2013‐ 02354913 Mutant p53 controls post‐transcriptional‐mediated oncosuppressor miRNAs maturation in colon cancer. REGINA ELENA gurtner aymone Biomedica Genes, Genomes and Genetics Molecular Genetics ‐ MGA RF‐2013‐ 02354917 Potential impact of a traditional Mediterranean Diet on estrogen, inflammation and cholesterol homeostasis: a Bermuda triangle for CVD risk? Sicilia carruba giuseppe Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative Nutrition and Metabolic Processes ‐ INMP Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Oncology 1 ‐ Basic Translational Cancer Genetics ‐ CG Pagina 186 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02354921 The MINA PROJECT. Mirror Neurons In Alcoholics: can Mirror Neuron System help us tounderstand and treat Alcohol Addiction? Emilia‐Romagna RF‐2013‐ 02354922 Abnormal phosphatidylcholine metabolism as a base for tailored molecular imaging and for therapy targeting in human triple negative breast cancer RF‐2013‐ 02354925 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Cristiana Biomedica Brain Disorders and Clinical Neuroscience Neural Basis of Psychopathology, Addictions and Sleep Disorders ‐ NPAS Istituto Superiore di Sanita' Iorio Egidio Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS Implementation and improvement of a predicting model of all‐cause mortality in patients with type 2 diabetes mellitus living in Apulia, Southern Italy. CASA SOLLIEVO SOFFERENZA De Cosmo Salvatore Clinico‐ Population Sciences and assistenzial Epidemiology e Kidney, Nutrition, Obesity and Diabetes ‐ KNOD RF‐2013‐ 02354927 Integration, Harmonization and Standardization of laboratory tools for disease monitoring and outcome prediction in non‐Hodgkin Lymphoma (NHL) in the context of the "Fondazione Italiana Linfomi" (FIL) network Piemonte Ladetto Marco Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02354928 MOTOR REHABILITATION IN SPINAL CORD INJURY: ENHANCING RECOVERY THROUGH COGNITION. Lombardia Bottini Gabriella Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Acute Neural Injury and Epilepsy ‐ ANIE RF‐2013‐ 02354930 Anti‐SAP (secreted aspartyl proteinases) antibodies to fight mucosal and systemic candidiasis. Umbria Vecchiarelli Anna Biomedica Infectious Diseases and Microbiology Pathogenic Eukaryotes ‐ PTHE RF‐2013‐ 02354932 Design of a double‐faced nanostructured wound dressing Istituto Superiore di Sanita' Baldassarri with regenerative and antimicrobial properties Lucilla Biomedica Bioengineering Sciences and Technologies Nanotechnology ‐ NANO RF‐2013‐ 02354933 CDKL5‐related neurodevelopmental diseases: a multidisciplinary study in a novel mouse model to foster efficient therapeutic approaches SAN RAFFAELE MILANO Nicoletta Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD RF‐2013‐ 02354937 STUDIES ON THE POTENTIAL USE OF EXTRACELLULAR VESICLES IN THE THERANOSTICS (THERAPY AND DIAGNOSIS, WHOLE IN ONE) OF CANCER Istituto Superiore di Sanita' Fais Stefano Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS Di Gennaro Landsberger Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 187 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02354939 Diagnostic and therapeutic devices emitting electromagnetic fields: effectiveness and safety for patients and workers Istituto Superiore di Sanita' Polichetti Alessandro Vittorio Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Electromagnetic Devices Special Emphasis Panel ‐ SEED RF‐2013‐ 02354940 LIPID NANOCARRIERS FOR PHOTODYNAMIC THERAPY OF GLIOBLASTOMA Istituto Superiore di Sanita' MOLINARI AGNESE Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT RF‐2013‐ 02354941 Modena Familial Cancer Clinic: organizing an health care Emilia‐Romagna service devoted to assess, counsel and manage people with hereditary cancer syndromes. Laura Clinico‐ Genes, Genomes and assistenzial Genetics e Genetics of Health and Disease ‐ GHD RF‐2013‐ 02354947 Therapeutic strategies against Influenza virus infection based on lactoferrin‐derived peptides Fabiana Biomedica Drug Discovery and Mechanisms of Antimicrobial Resistance ‐ DDR RF‐2013‐ 02354948 STELLA MARIS A double blind randomized controlled placebo trial to evaluate the efficacy of oral tetrabenazine and trihexyphenidyl in patients with dyskinetic cerebral palsy Battini Roberta Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Developmental Brain Disorders ‐ DBD RF‐2013‐ 02354949 Effectiveness of repeated immunizations with DNA plasmids encoding HER‐2/neu in the longterm prevention of mammary cancer in HER‐2/neu transgenic mice I.N.R.C.A. Provinciali Mauro Biomedica Cellular Mechanisms in Aging and Development ‐ CMAD RF‐2013‐ 02354953 Cogan's Syndrome: application of functional neuroimaging to autoimmune cerebral vessels' inflammation Emilia‐Romagna Mora Paolo Clinico‐ Immunology assistenzial e Hypersensitivity, Autoimmune, and Immune RF‐2013‐ 02354954 Identification of innovative therapeutic strategies regarding metastatic ovarian cancers Sicilia Todaro Matilde Biomedica Basic Mechanisms of Cancer Therapeutics ‐ BMCT RF‐2013‐ 02354955 PASCALE Preclinical and phase II clinical study of cisplatin, cetuximab and valproic acid in recurrent and/or metastatic squamous cell carcinoma of the head and neck Caponigro Francesco Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cortesi Istituto Superiore di Sanita' Superti Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Infectious Diseases and Microbiology Biology of Development and Aging Oncology 2 ‐ Translational Clinical Clinical Oncology ‐ CONC Pagina 188 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA RF‐2013‐ 02354956 Genetic Assessment of Reproductive Activity in BUffalo and CAttle IZSME CORRADO FEDERICA RF‐2013‐ 02354957 Role of anti‐epileptic drugs in epilepsy and psychiatric/neurologic comorbidity: a translationalstudy. Calabria De Sarro Giovambattista Clinico‐ RF‐2013‐ 02354958 Cyclic joint loading and molecular cartilage homeostasis: RIZZOLI towards the design of rehabilitation programs limiting progression of human knee osteoarthritis Leardini RF‐2013‐ 02354963 CCR5 specific antibody derived mimetic peptide against HIV transmission RF‐2013‐ 02354964 Menopause: Impact on cardiovascular Risk Veneto AugmentatioN and Outcome worsening (MIRANO) Study RF‐2013‐ 02354965 A DCE‐MRI quantitative index for prediction and early assessment of response to neo‐adjuvant radio‐ chemotherapy in locally advanced rectal cancer (LARC) RF‐2013‐ 02354970 P.I. Biomedica Classificazione 1 Liv. Classificazione 2° liv. Endocrinology, Metabolism, Nutrition and Reproductive Sciences Molecular and Cellular Endocrinology ‐ MCE Brain Disorders and assistenzial Clinical Neuroscience e Acute Neural Injury and Epilepsy ‐ ANIE Alberto Biomedica Musculoskeletal, Oral and Skin Sciences Skeletal Biology Structure and Regeneration ‐ SBSR Lopalco Lucia Biomedica AIDS and Related Research AIDS Discovery and Development of Therapeutics ‐ ADDT Tikhonoff Valerie Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Integrative and Clinical Endocrinology and Reproduction ‐ ICER PASCALE Petrillo Antonella Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC Stereotactic body radiation therapy (SBRT) with the Tomotherapy platform in primary and metastatic lung and liver tumor Sicilia ferrera giuseppe Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Radiation Therapeutics and Biology ‐ RTB RF‐2013‐ 02354973 New immunological markers for improving the cure of inborn haemoglobinopathies by hematopoietic stem cell transplantation Istituto Superiore di Sanita' Sanchez Massimo Biomedica Vascular and Hematology Hematopoiesis ‐ HP RF‐2013‐ 02354976 TROPHIC ACTIVITY OF SPERMIDINE SUPRAMOLECULAR COMPLEXES IN OSTEOARTHRITIS RIZZOLI Rosa Maria Biomedica Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ‐ ACTS SAN RAFFAELE MILANO Borzi' Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 189 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02354977 A metabolomics approach to identify aberrant signaling pathways in patients at risk for major cardiovascular events:studies in human subjects with diabetes and atherosclerosis RF‐2013‐ 02354978 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Federici Massimo Biomedica Vascular and Hematology Atherosclerosis and Inflammation of the Cardiovascular System ‐ AICS Targeting Mycobacterium surface constituents as a novel Lazio vaccination strategy against tuberculosis aimed at developing neutralizing antibodies. Delogu Giovanni Biomedica Infectious Diseases and Microbiology Host Interactions with Bacterial Pathogens ‐ HIBP RF‐2013‐ 02354979 Emilia‐Romagna Self‐monitoring test based on preferential hyperacuity perimetry versus standard clinical monitoring procedures in detecting the necessity of repetition of intravitreal treatment with anti‐angiogenic drugs for patients affected by neovascular age‐related PARMEGGIAN FRANCESCO I Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02354982 Linking purinergic P2X7 receptor to inflammation in Multiple Sclerosis: a novel target for therapy. Amadio Susanna Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02354983 Cockayne syndrome: targeting mitochondrial dysfunction Istituto Superiore di Sanita' D'Errico as a novel therapeutic approach to prevent neurodegeneration Mariarosaria Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND RF‐2013‐ 02354985 MICRORNA IN PAPILLARY THYROID CARCINOMA: PATHWAYS INVOLVED AND POSSIBLE PROGNOSTIC AND THERAPEUTIC IMPACT ISTITUTO TUMORI MILANO Borrello Maria Grazia Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB RF‐2013‐ 02354987 Identification of novel biomarkers for the checkpoint inhibitor treatment of melanoma patients I. O. V. Mandruzzato Susanna Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02354990 Evaluation of biological properties and in vivo persistence SAN MATTEO of human memory‐like Natural Killer cells as a tool for a novel approach of antitumor cell therapy in pediatric patients with high‐risk solid tumors given either autologous or allogeneic hemat MACCARIO RITA Clinico‐ Immunology assistenzial e Transplantation, Tolerance and Tumor Immunology ‐ TTT Lazio SANTA LUCIA Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 190 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02354991 Exploiting the p53 pathway: Molecular mechanisms of the I.E.O. increasing risk of breast cancer associated with aging MIGLIACCIO ENRICA Biomedica Biology of Development and Aging Cellular Mechanisms in Aging and Development ‐ CMAD RF‐2013‐ 02354996 Validation of the histone demethylase LSD1 as a target in acute myeloid leukemia I.E.O. MINUCCI SAVERIO Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC RF‐2013‐ 02354999 Hepatitis B Vaccination in HIV‐Positive Adults with Isolated Antibodies to HBV Core Antigen (Anti‐HBc): Evaluation of Humoral and Cellular Immune Response SAN RAFFAELE MILANO Morsica Giulia Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS RF‐2013‐ 02355001 Gene expression profiles in ovarian cancer. Focus on Sgk1 Calabria and related molecules in the development of patient tailored therapies. The modulation of Sgk1 kinase activity by Sgk1 interacting peptides and small molecules forinnovative therapeutic approach Perrotti Nicola Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT RF‐2013‐ 02355008 A Multidisciplinary Magnetic Resonance Imaging and Immunohistochemical study of human fetal malformation of cortical development. CARLO BESTA Frassoni Carolina Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD RF‐2013‐ 02355009 Protein and microRNA expression profiles of multiple sclerosis patients in glatiramer acetate treatment: potential biomarkers Puglia De Masi Roberto Biomedica Emerging Technologies and Neurotechnology ‐ Training in Neurosciences NT RF‐2013‐ 02355012 P2RX7, a gene modifier in ALS: genetic and functional analysis of polymorphisms in a cohort of ALS patients. SANTA LUCIA Volonté Cinzia Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02355013 Innovative therapies for the rescue of intellectual disability in Down syndrome, a model of genetic cognitive defect and Alzheimer's‐like dementia Campania Scala Iris Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD RF‐2013‐ 02355014 p73/HIF‐1alpha axis in physiological and pathological conditions ISTITUTO DERMOPATICO DELL'IMMACOLATA Melino Gerry Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 191 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355017 High throughput, population‐wide, reflex testing of colo‐ rectal cancer: molecular characterization, identification of individualized therapy targets and prevention of familial cases IRCCS AOU San Martino‐ IST (Genova) Mastracci Luca Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02355019 BIOLOGICAL APPROACH TO DECONTAMINATION OF BIVALVE MOLLUSCS FROM V.PARAHAEMOLYTICUS AND SALMONELLA BY BACTERIOVORAX SPECIES. IZSUM Ottaviani Donatella Biomedica Food Safety ‐ FOSA RF‐2013‐ 02355030 Role of Mediterranean Diet on breast cancer recurrence in postmenopausal women Calabria Montalcini Tiziana Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Integrative Nutrition and Metabolic Processes ‐ INMP RF‐2013‐ 02355034 A comparative study of polydeoxyribonucleotide (PDRN) Sicilia with hyperbaric oxygen (HBO) therapy on the healing of chronic diabetic foot ulcers. (THE POLYHBODFU study) Altavilla Domenica Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO RF‐2013‐ 02355040 Complementary vaccination with dendritic cells pulsed with autologous tumor lysate in resected stage III and IV melanoma patients: a phase II randomized trial Istituto Scientifico Romagnolo ridolfi laura Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII RF‐2013‐ 02355043 Prediction of liver adenoma and carcinoma onset by assessment of miRNA in the blood GASLINI Eva Alessandra Biomedica Genes, Genomes and Genetics Gene Therapy and Inborn Errors ‐ GTIE Special Emphasis Panel RF‐2013‐ 02355045 Hemorheological disorders and diabetes mellitus: the Progetto Diabete Calabria Study. Calabria Claudio Carallo Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO RF‐2013‐ 02355046 Combining integrated oxidative proteomic and metabolism profiles for the identification of novel pathogenetic mechanisms and therapies against hypertrophic cardiomiopathy and pigmentary retinopathy in mitochondrial trifunctional protein deficiency/long‐ch OSPEDALE BAMBINO GESU' Pastore Anna Biomedica Therapeutic Approaches to Genetic Diseases ‐ TAG Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Veterinary Genes, Genomes and Genetics Pagina 192 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355048 Enhanced recovery program in pancreatic surgery. An innovative approach to improve outcome and optimize resources. Lombardia GIANOTTI LUCA VITTORIO Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02355049 Calcium‐Calmodulin Kinases mediated regulation of human atherosclerotic plaques: role in vascularwall and infiltrating inflammatory cells Campania Illario Maddalena Biomedica Cardiovascular and Respiratory Sciences Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR RF‐2013‐ 02355050 EXPRESSION PROFILING IN HUMAN HORMONE‐ SECRETING NEUROENDOCRINE TUMORS IN ASSOCIATION WITH CLINICAL AND BIOCHEMICAL FEATURES AUXOLOGICO Pecori Giraldi Francesca Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Molecular and Cellular Endocrinology ‐ MCE RF‐2013‐ 02355051 Metagenomic analysis of infectious agents involved in colon polyps and cancer as innovative prevention and treatment strategies Istituto Superiore di Sanita' Di Bonito Paola Biomedica Infectious Diseases and Microbiology Clinical Research and Field Studies of Infectious Diseases ‐ CRFS RF‐2013‐ 02355052 Discovering metabolomic signatures associated with specific gene mutations in melanoma and their role in tumor radiosensitivity and immunogenicity. Istituto Superiore di Sanita' Rainaldi Gabriella Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME RF‐2013‐ 02355053 Multidrug Resistance of the Blood Brain Barrier: clinical implications and pharmacological activity of anticancer agents Toscana Sardi Iacopo Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT RF‐2013‐ 02355057 Immune responses of man and animals to infectious and non‐infectious stressors: identification of cross‐species host parameters of immunocompetence IZSLER Amadori Massimo Biomedica Immunology Innate Immunity And Inflammation ‐ III RF‐2013‐ 02355059 Providing indication for novel therapeutic strategies and drugs to improve outcome of recurrent osteosarcoma patients RIZZOLI Serra Massimo Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT RF‐2013‐ 02355061 Identification of new candidate Brugada Syndrome genes SAN RAFFAELE MILANO and advanced functional analysis in patient‐specific induced pluripotent stem cell models. Benedetti Sara Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 193 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355064 Development and Evaluation of Influenza Virus Istituto Superiore di Sanita' Puzelli Polymerase Inhibitors for Combination Antiviral Therapy RF‐2013‐ 02355066 A translational study of dysautonomia and other non‐ motor symptoms in parkinsonism NEUROMED RF‐2013‐ 02355068 MOLECULAR AND IMMUNOLOGICAL PATHWAYS INVOLVED IN ONSET AND MALIGNANCY OF EXPERIMENTAL OSTEOSARCOMA AND HEMANGIOSARCOMA AS TARGET OF INNOVATIVES THERAPIES. RIZZOLI RF‐2013‐ 02355072 The emerging role of microRNAs in autism spectrum disorders Associazione Oasi Maria SS Elia RF‐2013‐ 02355074 Innovative methods for autologous pancreatic beta cells and pseudo islets production. MULTIMEDICA RF‐2013‐ 02355075 DEVELOPMENT OF INSULIN‐PRODUCING BIOHYBRID ORGAN FOR THE CURE OF TYPE I DIABETES RF‐2013‐ 02355076 RF‐2013‐ 02355077 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Simona Biomedica Infectious Diseases and Microbiology Drug Discovery and Mechanisms of Antimicrobial Resistance ‐ DDR Fornai Francesco Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN Landuzzi Lorena Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB Maurizio Biomedica Genes, Genomes and Genetics Genomics, Computational Biology and Technology ‐ GCAT Biunno Ida Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular Aspects of Diabetes and Obesity ‐ CADO Umbria Calafiore Riccardo Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular Aspects of Diabetes and Obesity ‐ CADO Modulation of TIMELESS expression by miR‐139.5p influences cancer cell behavior and increases chemosensitivity in colorectal cancer CASA SOLLIEVO SOFFERENZA Mazzoccoli Gianluigi Biomedica Oncology 1 ‐ Basic Translational Tumor Progression and Metastasis ‐ TPM2 Elevated levels of HbA1c in subjects with normal glucose tolerance are associated with cardiovascular risk profile: role of soluble Receptor for Advanced Glycation End‐ products (sRAGE). Sicilia Piro Salvatore Biomedica Risk, Prevention and Health Behavior SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan ‐ TPM1 Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 194 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355078 Multi‐epitope ERBB2 targeting with humanized antibodies REGINA ELENA Giacomini Patrizio Biomedica Bioengineering Sciences and Technologies Nanotechnology ‐ NANO RF‐2013‐ 02355080 Strengthening the public health through the use of bivalve molluscs as indicators of environmental contamination by human activity that affect food safety IZSUM Latini Mario Biomedica Veterinary Food Safety ‐ FOSA RF‐2013‐ 02355083 NEUROPHYSIOLOGICAL AND OPTOGENETIC ASSESTMENT OF SYNAPTIC PLASTICITY IN DYT11 DYSTONIA SANTA LUCIA Martella Giuseppina Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02355085 Development Of A Novel Adoptive Cell Transfer Approach (ACT) For Cancer Immunotherapy Based On The Use Of Autologous IFN‐DC For The Induction Of Anti‐Tumor Response And Implemented By Strategies Aimed At Extending The Replicative Lifespan Of The Anti‐Tumo Istituto Superiore di Sanita' Santini Stefano Maria Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII RF‐2013‐ 02355088 ISTITUTO TUMORI Next generation sequencing to uncover novel markers and therapeutic targets for radioiodine‐resistant papillary MILANO thyroid carcinoma Greco Maria Angela Biomedica Oncology 1 ‐ Basic Translational Cancer Genetics ‐ CG RF‐2013‐ 02355089 PATHOGENIC CHARACTERIZATION OF AUTOSOMAL STELLA MARIS RECESSIVE SPASTIC‐ATAXIA OF CHARLEVOIX‐ SAGUENAY TRHOUGH STUDIES IN VITRO AND IN VIVO Tessa Alessandra Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD RF‐2013‐ 02355092 Ethical Counseling Service I.E.O. Boniolo Giovanni Clinico‐ Healthcare Delivery and assistenzial Methodologies e RF‐2013‐ 02355102 The effect of physiologically representative complex context on Total Knee Replacement wear. Toward the interpretation and the knowledge of tribological processes in joint prostheses. RIZZOLI Affatato Maria Ulderico Biomedica Saverio Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Surgical Sciences, Biomedical Imaging, and Bioengineering Classificazione 2° liv. Research on Ethical Issues in Human Studies ‐ REHS Small Business Bioengineering, Surgical Sciences, and Technology ‐ SBTS (SBIR/STTR) Pagina 195 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355103 Exosome‐mediated RNA interference: a new therapeutic strategy for HPV‐induced cancer Istituto Superiore di Sanita' Chiantore RF‐2013‐ 02355104 Genetic and antigenic diversity and pathogenicity of viruses associated with enteritis Emilia‐Romagna RF‐2013‐ 02355105 SAN RAFFAELE MILANO D2 resection and HIPEC (hyperthermic intraperitoneal chemoperfusion) in locally advanced gastric carcinoma: a randomized and multicentric phase III study. RF‐2013‐ 02355109 Novel pathways to chemoresistance in chronic lymphocytic leukemia: study of Toll‐like receptors signaling molecules. RF‐2013‐ 02355113 AREA P.I. Maria Vincenza Biomedica Classificazione 1 Liv. Classificazione 2° liv. Bioengineering Sciences and Technologies Nanotechnology ‐ NANO Infectious Diseases and Microbiology Infectious Diseases and Microbiology Fellowship ‐ F13 Medici Maria Cristina Biomedica Orsenigo Elena Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Surgery, Anesthesiology, and Trauma ‐ SAT SAN RAFFAELE MILANO Muzio Marta F Biomedica Immunology Innate Immunity And Inflammation ‐ III Targeting stress response pathways in human melanoma ISTITUTO TUMORI MILANO Anichini Andrea Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP RF‐2013‐ 02355138 Role of HMGB1 in Doxorubicin‐induced cardiotoxicity MONZINO Milano Giuseppina Biomedica Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF RF‐2013‐ 02355139 A NANOMEDICINE APPROACH FOR TRIPLE NEGATIVE BREAST CANCER (TNBC). TARGETING THROUGH INNOVATIVE NANOPARTICLE‐APTAMER BIOCONJUGATES. Toscana crispino sergio Biomedica Oncology 2 ‐ Translational Clinical Developmental Therapeutics ‐ DT RF‐2013‐ 02355141 Extracellular vesicles in the crosstalk between adipocytes Piemonte and pancreatic beta‐cells: link with obesity and diabetes. Granata Riccarda Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular Aspects of Diabetes and Obesity ‐ CADO RF‐2013‐ 02355142 Molecular, immunological and imaging determinants of Emilia‐Romagna outcome in sorafenib‐treated patients with hepatocellular carcinoma Missale Gabriele Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 196 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA RF‐2013‐ 02355144 Quality of life in spinal cord injury: methods of MAUGERI measurements and correlation with individual parameters RF‐2013‐ 02355146 The bank vole as a novel animal model for investigating the prion‐like properties of tauopathies. Istituto Superiore di Sanita' Di Bari RF‐2013‐ 02355147 Genetic dissection of cystic fibrosis host susceptibility to Pseudomonas aeruginosa infections using a highly genetically diverse mouse resource population, the Collaborative Cross mice SAN RAFFAELE MILANO Bragonzi Alessandra RF‐2013‐ 02355150 Development of new technologies to promote thymic regeneration for the treatment of Primary Immunodeficiencies SAN RAFFAELE MILANO Bosticardo RF‐2013‐ 02355152 Mitochondrial dysfunction and iron (dys)‐metabolism in Neurodegeneration with Brain Iron Accumulation (NBIA): an integrated approach based on human neuronal cellular systems CARLO BESTA Tiranti RF‐2013‐ 02355161 A new potential therapeutic for Rett Syndrome: a preclinical study RF‐2013‐ 02355163 P.I. Fizzotti Gabriella Classificazione 1 Liv. Classificazione 2° liv. Clinico‐ Healthcare Delivery and assistenzial Methodologies e Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN Biomedica Infectious Diseases and Microbiology Host Interactions with Bacterial Pathogens ‐ HIBP Marita Biomedica Genes, Genomes and Genetics Therapeutic Approaches to Genetic Diseases ‐ TAG Valeria Sonia Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN Istituto Superiore di Sanita' Fiorentini Carla Biomedica Molecular, Cellular, and Developmental Neuroscience Drug Discovery in the Nervous System ‐ ZRG1 MNPS Systems data for individual renal cancer medicine ISTITUTO TUMORI MILANO Bongarzone Italia Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02355164 Molecular mechanisms and therapeutic implications of alpha 7 nAChR anti‐inflammatory pathways in the prevention of obesity‐linked co‐morbidities AUXOLOGICO Cancello Raffaella Biomedica Cell Biology Molecular and Integrative Signal Transduction ‐ MIST RF‐2013‐ 02355165 Dendritic cell‐based vaccine therapy in mesothelioma patients: preclinical and phase I clinical studies Istituto Superiore di Sanita' Proietti Enrico Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Michele Angelo Biomedica Biomedical Computing and Health Informatics ‐ BCHI Pagina 197 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355166 Caffeine as a potential therapeutic option for Alzheimer's Istituto Superiore di Sanita' Popoli disease RF‐2013‐ 02355167 Tumor and immune cells cross‐talk in osteosarcoma: additional treatment opportunities RF‐2013‐ 02355169 A natural Aß variant with dominant negative effect on CARLO BESTA amyloidogenesis engineered to tackle Alzheimer's disease RF‐2013‐ 02355180 Development of a biotech system for natural compound production, by plant in vitro tissueculture, for the prevention and treatment of human dismetabolic diseases. RF‐2013‐ 02355181 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Patrizia Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN Scotlandi Katia Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME Di Fede Giuseppe Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN Istituto Superiore di Sanita' Loizzo Stefano Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative Nutrition and Metabolic Processes ‐ INMP PARP inhibition as therapeutic target for Huntington's disease SANTA LUCIA Fusco Francesca Romana Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02355182 Neurons derived from induced pluripotent stem cells from multiple sclerosis patients as a tool for studying pathogenic disease mechanisms and identifying novel neuroprotective compounds SAN RAFFAELE MILANO Martino Gianvito Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT RF‐2013‐ 02355185 dl922‐947 oncolytic virus and innate immune response stimulation in Anaplastic Thyroid Carcinoma models Campania Portella Giuseppe Biomedica Oncology 2 ‐ Translational Clinical Developmental Therapeutics ‐ DT RF‐2013‐ 02355189 Biological aging and urban pollution Veneto MAESTRELLI PIERO Biomedica Cardiovascular and Respiratory Sciences Lung Injury, Repair, and Remodeling ‐ LIRR RF‐2013‐ 02355190 Sphingolipid inflammatory mediators in Alzheimer disease pathogenesis and spread FATEBENEFRATELLI Benussi Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN RIZZOLI Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Luisa Pagina 198 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355203 Nanoparticle‐dependent delivery of steroids for the treatment of primary biliary cirrhosis to increase their therapeutic index RF‐2013‐ 02355207 Neonicotinoids and pyrethroids, an emerging health issue IZSAM for bees and humans RF‐2013‐ 02355208 Pain in Parkinson's Disease. A multidisciplinary clinical, neurophysiological and transcranial brain stimulation approach. RF‐2013‐ 02355209 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. INVERNIZZI PIETRO Biomedica Digestive, Kidney and Urological Systems Clinical, Integrative and Molecular Gastroenterology ‐ CIMG Scortichini Giampiero Biomedica Veterinary Food Safety ‐ FOSA Veneto TINAZZI MICHELE Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN Defining molecular targets that govern the capacity of platelets to support hepatitis B virus (HBV)‐associated liver immunopathology SAN RAFFAELE MILANO Guidotti Luca Biomedica Immunology Immunity and Host Defense ‐ IHD RF‐2013‐ 02355214 Idiopathic Inflammatory Myopathies: identification of a diagnostic epigenetic biomarker ‐ MYOMIRNA Emilia‐Romagna Cenacchi Giovanna Biomedica Musculoskeletal, Oral and Skin Sciences Musculoskeletal, Oral and Skin Sciences Small Business ‐ SEMO RF‐2013‐ 02355216 Cytokines and adipokines in phenotyped COPD as inflammatory biomarkers in relation to extrapulmonary manifestations and dysmetabolism. Toscana Parronchi Paola Biomedica Cardiovascular and Respiratory Sciences Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR RF‐2013‐ 02355218 The P2X7/inflammasome axis: a key player in adipose tissue metabolism in health and disease. Toscana Solini Anna Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative Physiology of Obesity and Diabetes ‐ IPOD RF‐2013‐ 02355220 Deciphering TDP‐43 properties in the Fronto Temporal Dementia/Amyotrophic Lateral Sclerosis spectrum disorders. SANTA LUCIA Longone Patrizia Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN HUMANITAS Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 199 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355223 ROLE OF THE NOVEL PROTEIN DEPDC5 IN NEURONAL PHYSIOLOGY AND PATHOGENESIS OF FAMILIAL FOCAL EPILEPSIES: POTENTIAL THERAPEUTIC IMPLICATIONS. RF‐2013‐ 02355227 PINOCCHIO: computed‐aided Planning and monItoriNg RIZZOLI biological bOne reConstructions in CHIldren Oncology. RF‐2013‐ 02355228 MECHANISMS GOVERNING THE PERITONEAL DISSEMINATION AND THE CHEMORESISTANCE OF THE EPITHELIAL OVARIAN CANCER RF‐2013‐ 02355230 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Bisulli Francesca Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN Taddei Fulvia Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Computational modeling and sciences for biomedical and clinical applications ‐ ZRCM ISTITUTO TUMORI MILANO Tomassetti Antonella Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB NEW STRATEGIES FOR MUCOSAL VACCINATION AGAINST HELICOBACTER PYLORI AND CLOSTRIDIUM DIFFICILE INFECTIONS Toscana GHELARDI EMILIA Biomedica Infectious Diseases and Microbiology Infectious Diseases and Microbiology Fellowship ‐ F13 RF‐2013‐ 02355231 INSIDE: INtegrated in SIlico and in vivo approach to uncover the hidden genetic basis of GnRH neuron DEficiency AUXOLOGICO Bonomi Marco Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative and Clinical Endocrinology and Reproduction ‐ ICER RF‐2013‐ 02355240 An integrated approach to unravel the genetic causes and Toscana molecular pathogenesis of epileptogenic focal cortical dysplasia. Guerrini Renzo Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Developmental Brain Disorders ‐ DBD RF‐2013‐ 02355241 Validation of pharmacogenetic enhancement of Ras‐ERK signalling to prevent neurodegeneration and cognitive deficits in mouse models of Parkinson's Disease. SAN RAFFAELE MILANO Fasano Stefania Biomedica Cellular and Molecular Biology of Neurodegeneration ‐ CMND RF‐2013‐ 02355242 Anti‐Cholinergic receptors antibodies, cardiovascular autonomic profile and dysautonomia symptoms relationships in Pure Autonomic Failure, Amyotrophic Lateral Sclerosis and Postural Orthostatic Tachycardia Syndrome: evidence for a pathophysiology based th HUMANITAS Furlan Raffaello Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Istituto Scienze Neurologiche Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Molecular, Cellular, and Developmental Neuroscience Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR Pagina 200 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355245 Can we identify the structural and genetic traits of bone‐ impairing dismetabolisms? A pilot study in Osteogenesis Imperfecta and Klinefelter Syndrome patients. RF‐2013‐ 02355247 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Baruffaldi Fabio Biomedica Musculoskeletal, Oral and Skin Sciences Skeletal Biology Development and Disease ‐ SBDD Toscana How to face the emergence of multidrug resistant carbapenemases producing Klebsiella pneumoniae strains causing bacteremia/septicemia. Lupetti Antonella Biomedica Infectious Diseases and Microbiology Drug Discovery and Mechanisms of Antimicrobial Resistance ‐ DDR RF‐2013‐ 02355249 A new model to evaluate surgical readmission rates as hospitals' quality‐of‐care indicator Sicilia Vitale Francesco Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02355257 Insulin‐Resistance, Inflammation and Cardiovascular Risk: Molecular Bases, Pathophysiological, Clinical and Therapeutic Implications of the High Mobility Group Protein AT‐Hook 1 (HMGA1) Calabria BRUNETTI ANTONIO Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO RF‐2013‐ 02355259 Cardiac amyloidosis: molecular mechanism and innovative therapies for a challenging aging related cardiomyopathy SAN MATTEO MERLINI GIAMPAOLO Biomedica Biological Chemistry and Macromolecular Biophysics Macromolecular Structure and Function B ‐ MSFB RF‐2013‐ 02355260 SELECTIVE AXILLARY LYMPH NODE DISSECTION VS COMPLETE AXILLARY DISSECTION: A RANDOMISED CLINICAL TRIAL TO ASSESS THE PREVENTION OF LYMPHEDEMA IN BREAST CANCER TREATMENT ISTITUTO TUMORI MILANO Gennaro Massimiliano Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Surgery, Anesthesiology, and Trauma ‐ SAT RF‐2013‐ 02355261 Can diet and metabolic factors affect efficacy and toxicity Sicilia of chemotherapy in cancer patients? Frittitta Lucia Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Chemo/Dietary Prevention ‐ CDP RF‐2013‐ 02355262 Regulation of SMN2 splicing in cell and mouse models of SANTA LUCIA Spinal Muscular Atrophy Sette Claudio Biomedica Therapeutic Approaches to Genetic Diseases ‐ TAG RIZZOLI Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Genes, Genomes and Genetics Pagina 201 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355274 Computer‐aided diagnosis of brain amyloidosis in PET imaging. Implementation of the automatic, SUVR‐ independent scoring system for EvaLuation of Brain Amyloidosis (ELBA) in two groups of subjects, having maximum (i.e., patients with certified Alzheimer's IRCCS AOU San Martino‐ IST (Genova) Nobili Flavio Mariano Biomedica RF‐2013‐ 02355277 A multidisciplinary approach to optimize the clinical management of patients and make it ready to the new diagnostic and therapeutic opportunities. The case of arrhythmogenic inherited diseases. Piemonte Giustetto Carla Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Electrical Signaling, Ion Transport, and Arrhythmias ‐ ESTA RF‐2013‐ 02355280 Endocrine evaluation in patients with traumatic brain injury. Study correlation between endocrine parameters, body composition, and neurocognitive, neurobehavioral and quality of life aspects SDN Di Somma Carolina Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Integrative and Clinical Endocrinology and Reproduction ‐ ICER RF‐2013‐ 02355281 Membrane composition and dynamics in Plasmodium‐ Istituto Superiore di Sanita' Ponzi infected erythrocytes: new approaches for malaria control Marta Biomedica Infectious Diseases and Microbiology Pathogenic Eukaryotes ‐ PTHE RF‐2013‐ 02355282 An innovative and affordable next generation sequencing‐ SAN RAFFAELE MILANO based strategy for the diagnosis of drug resistant tuberculosis and therapy follow up. Cirillo Daniela Maria Biomedica Infectious Diseases and Microbiology Clinical Research and Field Studies of Infectious Diseases ‐ CRFS RF‐2013‐ 02355284 IMPLEMENTATION OF LIVER CIRRHOSIS DIAGNOSIS Veneto AND DEVELOPMENT OF A TELEMEDICINE PROJECT FOR TERRITORIAL MANAGEMENT Patrizia Pontisso Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Clinical, Integrative and Molecular Gastroenterology ‐ CIMG RF‐2013‐ 02355287 ATP‐P2X7R immunity promotes breakdown of tolerance in type 1 diabetes Zuccotti Gian Vincenzo Biomedica Immunology Transplantation, Tolerance and Tumor Immunology ‐ TTT RF‐2013‐ 02355290 IRCCS AOU San Martino‐ Therapeutic targets in Chronic Lymphocytic Leukemia (CLL): a study based on microenvironment and leukemic IST (Genova) B cells cross‐talk. Cutrona Giovanna Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT Lombardia Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN Pagina 202 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355294 Validation of the Long ncRNA TRPM2‐AS as a Novel Prognostic Marker and Therapeutic Target in Prostate Cancer Patients with Pelvic Lymph Node Invasion RF‐2013‐ 02355303 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Lavorgna Giovanni Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB Neurobiological Mechanisms Underlying Effectiveness of MEDEA Cognitive‐Behaviour Treatment in childhood and adolescence Anxiety Disorders Nobile Maria Biomedica Biobehavioral and Behavioral Processes Biobehavioral Mechanisms of Emotion, Stress and Health ‐ MESH RF‐2013‐ 02355304 Circulating microRNA signatures for glioblastoma multiforme Veneto Dechecchi Maria Cristina Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02355305 Role of 'non‐classical' renin‐angiotensin‐system in the progression of diabetic nephropathy in a rat model of type 1 diabetes. SAN MATTEO ZONTA SANDRO Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular Aspects of Diabetes and Obesity ‐ CADO RF‐2013‐ 02355308 Efficacy of Albumin Replacement and Balanced Solution MAGGIORE in Patients with Septic Shock (the ALBIOSS‐BALANCED trial): a 2‐by‐2 factorial, investigator‐initiated, open‐label, multicenter, randomized, controlled trial. Caironi Pietro Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS RF‐2013‐ 02355312 Diabetes Ketoacidosis in children and adolescents: an Italian nationwide study on clinical, social and economic impact cherubini valentino Clinico‐ Population Sciences and assistenzial Epidemiology e Kidney, Nutrition, Obesity and Diabetes ‐ KNOD RF‐2013‐ 02355323 MAGGIORE Brain mitochondrial dysfunction, abnormal thermodynamics and inflammation in Parkinson's disease: investigation of three interrelated putative causes rango mario Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02355324 Analysis of plasma and urinary extracellular vesicles in kidney transplant recipients for the detection and monitoring of immunologic and infectious complications Piemonte Biancone Luigi Biomedica Digestive, Kidney and Urological Systems Cellular and Molecular Biology of the Kidney ‐ CMBK RF‐2013‐ 02355326 Rab39b mouse models: pre‐clinical studies by using AMPA receptors as possible therapeutic targets to unravel the role of RAB39B in Intellectual Disability and Autism Spectrum Disorder SAN RAFFAELE MILANO D'Adamo Patrizia Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD SAN RAFFAELE MILANO Marche Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 203 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355329 Innovative strategies to harness the immune system against cancer with bispecific antibodies Lombardia Golay Josee Therese Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII RF‐2013‐ 02355332 Alteration of lipoproteins in HIV‐infected patients: implications for cardiovascular disease. SPALLANZANI Alonzi Tonino Biomedica AIDS and Related Research AIDS Immunology and Pathogenesis ‐ AIP RF‐2013‐ 02355339 BRADEION AS A URINARY MARKER OF TRANSITIONAL CELL CANCER OF THE BLADDER: VALIDATION BY RT‐PCR OF SEPT4 TRANSCRIPTS AND DEVELOPMENT OF A DIAGNOSTIC TEST Sicilia BONGIOVAN LUCA NI Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02355343 Innovative biotechnologies for the assessment of Excessive Physical Activity (EPA), heart rate variability and stress levels in early adolescents with anorexia nervosa restrictive subtype (ANR) STELLA MARIS Maestro Sandra Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Pathophysiological Basis of Mental Disorders and Addictions ‐ PMDA RF‐2013‐ 02355359 Association between intestinal microbiome and cardiorenal syndrome in chronic heart failure patients Puglia Iacoviello Massimo Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR RF‐2013‐ 02355370 Protein aggregation and dysregulation of RNA metabolism in FET model of ALS SANTA LUCIA PARONETTO MARIA PAOLA Biomedica RF‐2013‐ 02355373 RELATIONSHIP BETWEEN OBESITY, DIABETES MELLITUS , DYSLIPIDEMIA AND CARDIOVASCULAR DISEASES Toscana Di Bello Vitantonio Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF RF‐2013‐ 02355375 P2X ionotropic receptors as therapeutic targets in dystrophin and sarcoglycan deficient muscular dystrophies GASLINI Bruno Claudio Biomedica Skeletal Muscle Biology and Exercise Physiology ‐ SMEP Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Molecular, Cellular, and Developmental Neuroscience Musculoskeletal, Oral and Skin Sciences Classificazione 2° liv. Cellular and Molecular Biology of Neurodegeneration ‐ CMND Pagina 204 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355377 Dendritic cells based immune treatment in HIV‐1 infected patients from the International Consortium of DC Vaccine: whole genome and functional expression analyses BURLO GAROFALO CROVELLA SERGIO Biomedica AIDS and Related Research HIV/AIDS Vaccines ‐ VACC RF‐2013‐ 02355378 Changes in post‐transcriptional gene regulation in ALSdue to expansion of the c9orf72 repeats SANTA LUCIA Carrì Maria Teresa Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND RF‐2013‐ 02355383 The role of Cardiac Ankyrin Repeat Protein in cardiac inflammatory pathways and remodeling associated with human dilated, hypertrophic, and post‐inflammatory cardiomyopathy. HUMANITAS Bang Marie‐Louise Biomedica Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF RF‐2013‐ 02355394 Gut‐kidney axis: Renal effect of Mediterranean Diet and of Low‐protein Diet with Ketoacids to restore the physiological intestinal microbiota in Chronic Kidney Disease (CKD) Campania Di Iorio Biagio Raffaele Biomedica Digestive, Kidney and Urological Systems Renal and Urological Sciences Small Business Activities ‐ SERU RF‐2013‐ 02355405 miRNA based therapeutics to target protumorigenic potential of stromal fibroblasts in lung cancer ISTITUTO TUMORI MILANO Roz Luca Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME RF‐2013‐ 02355414 Computer Assisted Evaluation of Fracture Risk in Tumor Spine Lesions RIZZOLI Schileo Enrico Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Computational modeling and sciences for biomedical and clinical applications ‐ ZRCM RF‐2013‐ 02355421 QUANTIFICATION OF IGF‐1 ISOFORMS AND ANALYSIS OF THEIR FUNCTION IN BREAST CANCER ISTITUTO TUMORI MILANO Villarini Anna Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02355423 Chronic kindey disease, Arterial Stiffness and Target blood pressure (The CAST Study) MAGGIORE Meazza Roberto Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Clinical and Integrative Cardiovascular Sciences ‐ CICS Pagina 205 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355425 Use of Fluorine‐18‐fluorodeoxyglucose (18F‐FDG) positron emission tomography (PET) scan in guiding treatment and determining prognosis in pulmonary sarcoidosis SAN RAFFAELE MILANO Cremona George Ian Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Medical Imaging ‐ MEDI RF‐2013‐ 02355426 Peripheral nervous system involvement and neuropathic pain in immunoglobulin light chain (AL) amyloidosis: epidemiology and identification of novel "omic" markers for diagnosis, outcome prediction and response assessment SAN MATTEO Palladini Giovanni Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02355428 Genetics of taste perception, life style, health status and colorectal cancer risk. Piemonte Polizzi Salvatore Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD RF‐2013‐ 02355429 Approach to patients with shock due to systemic capillary Lombardia leak syndrome (Clarkson Disease) admitted to emergency departments of Regione Lombardia and identification of the mechanisms leading to the increase in endothelial permeability responsible for the Cicardi Marco Biomedica Cardiovascular and Respiratory Sciences Physiology and Pathobiology of Musculoskeletal, Oral, and Skin Systems ‐ PPMO RF‐2013‐ 02355435 EVA: Early Vascular Abnormalities in IUGRPrenatal and postnatal detection of cardiovascular disorders in intrauterine growth restricted fetuses and neonates: a multicentric clinical and biochemical study Veneto Cosmi Erich Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Cardiovascular Differentiation and Development ‐ CDD RF‐2013‐ 02355436 Molecular taxonomy of (familial) spinal Sicilia Magro Gaetano Giuseppe Biomedica Genes, Genomes and Genetics Genomics, Computational Biology and Technology ‐ GCAT RF‐2013‐ 02355437 Establishing a platform for the translatomic analysis of ALS/FTD pathogenesis and disease progression in transgenic models SAN RAFFAELE MILANO Consalez Giangiacomo Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN RF‐2013‐ 02355438 Heart remodelling and exercise tolerance in chronic obstructive pulmonary disease related to different phenotypes of the disease Emilia‐Romagna Pelà Giovanna Maria Biomedica Cardiovascular and Respiratory Sciences Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 206 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355439 Interplay between the decidual microenvironment and HLA‐G‐expressing regulatory cells in promoting tolerance at the fetal‐maternal interface. SAN RAFFAELE MILANO Gregori Silvia Biomedica RF‐2013‐ 02355442 Patient‐Specific Induced Pluripotent Stem Cells for Amyotrophic Lateral Sclerosis drug screening Piemonte Mazzini Letizia Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02355444 Immunomediated mechanisms of disease progression in multiple myeloma Puglia Ria Roberto Clinico‐ Oncology 1 ‐ Basic assistenzial Translational e Tumor Microenvironment ‐ TME RF‐2013‐ 02355448 Long‐term prognosis and mortality fifteen after acute Veneto coronary syndrome: the ABC* study on acute coronary syndrome (*ABC is acronym for Adria, Bassano, Conegliano, and Padova Hospitals): malignancies, stroke, gender prognostic difference. berton giuseppe Clinico‐ Population Sciences and assistenzial Epidemiology e Epidemiology of Cancer ‐ EPIC RF‐2013‐ 02355451 Molecular bases for personalized medicine in psoriatic patients: analysis of expression and function of the PSORS1 locus gene CCHCR1 Cavani Andrea Biomedica Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ‐ ACTS RF‐2013‐ 02355468 I.E.O. Prognostic value of EndoPredict (EP) score in premenopausal women with newly diagnosed endocrine‐ responsive breast cancers treated with hormonal therapy in the IBCSG (International Breast Cancer Study Group) SOFT and TEXT trials. Munzone Elisabetta Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02355469 Addressing the role of RPF‐1 developmental factor in the ISTITUTO TUMORI epigenetic landscape of Wilms tumor and Neuroblastoma MILANO pediatric cancers fiorino antonio Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP RF‐2013‐ 02355470 The long pentraxin PTX3 in cancer: a novel player in cancer‐related inflammation Garlanda Cecilia Biomedica Immunology Transplantation, Tolerance and Tumor Immunology ‐ TTT ISTITUTO DERMOPATICO DELL'IMMACOLATA HUMANITAS Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Endocrinology, Metabolism, Nutrition and Reproductive Sciences Pregnancy and Neonatology ‐ PN Pagina 207 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355471 The Neural Bases of Impaired Facial Emotion Recognition Emilia‐Romagna in Borderline Personality Disorder De Panfilis Chiara Biomedica RF‐2013‐ 02355473 Advanced therapies in Parkinson¿s disease. Clinical and NEUROMED neurophysiological effects of continuous duodenal/jejunal levodopa/carbidopa pump infusion and deep brain stimulation of the subthalamic nucleus (STN) Fabbrini Giovanni Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02355476 Identificazione di sistemi di rilascio ottimali per i Nucleic Campania Acid Based Drugs e studio dei meccanismi di azione in alcuni modelli di patologie umane infiammatorie /Identification of optimal delivery systems for the Nucleic Acid Based Drugs and study of t Piazza Ornella Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Lung Injury, Repair, and Remodeling ‐ LIRR RF‐2013‐ 02355478 New biomarkers to predict prognosis and tailor systemic therapy in patients with Pseudomyxoma Peritonei Deraco Marcello Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC RF‐2013‐ 02355482 SAN RAFFAELE MILANO Dynamic tracing of the impact of neutralising and inhibitory‐non‐neutralising antibodies on HIV‐1 infection of dendritic cells and macrophages at mucosal sites. Scarlatti Gabriella Biomedica AIDS and Related Research AIDS Immunology and Pathogenesis ‐ AIP RF‐2013‐ 02355495 Uncoupling protein‐2 and increased stroke susceptibility in stroke‐prone spontaneously hypertensive rat. Relevance for the human disease. NEUROMED Rubattu Speranza Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD RF‐2013‐ 02355496 Novel molecular and cellular pathophysiological mechanisms of diabetic vascular disease Abruzzo De Caterina Raffaele Biomedica Cardiovascular and Respiratory Sciences Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR RF‐2013‐ 02355498 Intestinal microbiome biomarkers for non‐celiac gluten sensitivity: new diagnostic and therapeutic targets. Emilia‐Romagna DE GIORGIO ROBERTO Biomedica Genes, Genomes and Genetics Genomics, Computational Biology and Technology ‐ GCAT ISTITUTO TUMORI MILANO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Integrative, Functional, and Cognitive Neuroscience Cognitive Neuroscience ‐ COG Pagina 208 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355499 Global Rare Tumor Networking and new staging/prognostic concepts in Thymic Epithelial Tumors and in Non Small Cell Lung Carcinomas metastatic to the Mediastinum: an integrated clinicopathological and molecular study REGINA ELENA Marino Mirella Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02355500 Innate immunity in HIV patients who do not recover the immune system after successful antiretroviral therapy: the role of the inflammasome. Emilia‐Romagna Mussini Cristina Clinico‐ AIDS and Related Research assistenzial e AIDS Clinical Studies and Epidemiology ‐ ACE RF‐2013‐ 02355503 Gastrointestinal Tract Permeability and Inflammation in HIV‐Infected patients with mild to moderate Chronic Kidney Disease: a cross‐over, double blind, randomized clinical trial Emilia‐Romagna Guaraldi Giovanni Biomedica AIDS Clinical Studies and Epidemiology ‐ ACE RF‐2013‐ 02355504 NEW DIAGNOSTIC AND THERAPEUTIC APPROACHES Emilia‐Romagna IN PATIENTS WITH ALCOHOLIC AND DYSMETABOLIC CIRRHOSIS AND ALCOHOL CONSUMPTION Bernardi Mauro Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Hepatobiliary Pathophysiology ‐ HBPP RF‐2013‐ 02355505 bedside to bench investigation of the cardiac adverse effects of proteasome inhibition: observational study in multiple myeloma patients, and molecular investigation in experimental models of proteasome failure dependent cardiomyopathy. Piazza Francesco Biomedica Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF RF‐2013‐ 02355519 Postural sway and facial mimicry as behavioral markers of SANTA LUCIA covert motor symptoms in Parkinson's disease in a new differential early diagnostic protocol. Pavone Enea Francesco Biomedica Biobehavioral and Behavioral Processes Adult Psychopathology and Disorders of Aging ‐ APDA RF‐2013‐ 02355520 Brain Development in Children Born Preterm: an fMRI, Psychological and Neurological Follow up at Scholar Age SAN RAFFAELE MILANO Scifo Paola Vittoria Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Developmental Brain Disorders ‐ DBD RF‐2013‐ 02355524 Metal on metal hip prosthesis: Cobalt‐induced neurotoxicity RIZZOLI Toni Aldo Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Cell Death in Neurodegeneration ‐ CDIN Veneto Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. AIDS and Related Research Pagina 209 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355526 DC vaccination combined with radiotherapy and/or preemptive IFN‐alpha in melanoma: a phase II clinical study Istituto Scientifico Romagnolo Guidoboni Massimo Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII RF‐2013‐ 02355529 ExoND ‐ Cross disease identification and analysis of exosomal cargo signature: implication for neuroprotection and therapeutics in neurodegenerative diseases. MONDINO Fuzzati‐ Armentero Marie Thérese Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN RF‐2013‐ 02355537 Cross talk between stromal cells, inflammation and reactive oxygen species: Their impact on cancer cell growth, survival, and cancer drug sensitivity SDN Laukkanen Mikko Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME RF‐2013‐ 02355539 Development and testing of an active, light weight, wearable lower limb exoskeleton for gait assistance in older persons. DON GNOCCHI Molino Lova Raffaele Biomedica Musculoskeletal, Oral and Skin Sciences Musculoskeletal Rehabilitation Sciences ‐ MRS RF‐2013‐ 02355543 Prenylcysteine Lyase as a potential novel player in atherosclerosis MONZINO Banfi Cristina Biomedica Vascular and Hematology Atherosclerosis and Inflammation of the Cardiovascular System ‐ AICS RF‐2013‐ 02355554 Hexabromocyclodecanes (HBCDDs) and Novel Brominated Flame Retardants (NBFRs): food levels, environmental contamination and toxicological effects. IZSUM Piersanti Arianna Biomedica Veterinary Food Safety ‐ FOSA RF‐2013‐ 02355566 REGINA ELENA Improvement of gliomas diagnosis and treatment: genomic alteration, imaging characteristic and circulating miRNA studies Vidiri Antonello Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02355570 Role of angiotensin‐converting enzymes inhibitors on cardioprotection against anticancer therapy‐induced cardiotoxicity: in vivo clinical evidences along with in vitro studies CARDINALE DANIELA MARIA Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC RF‐2013‐ 02355572 HAART and pregnancy: cellular/tissue impact analysis in SPALLANZANI pregnant women and utero‐exposed newborn, and identification of new stress‐related biomarker Corazzari Marco Biomedica AIDS Clinical Studies and Epidemiology ‐ ACE I.E.O. Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. AIDS and Related Research Pagina 210 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355574 Personalized multidisciplinary therapy in head and neck cancer based on clinical and molecular markers C.R.O. AVIANO Franchin Giovanni Biomedica Oncology 1 ‐ Basic Translational Tumor Progression and Metastasis ‐ TPM2 RF‐2013‐ 02355579 MESENCHYMAL STROMAL CELLS BEHAVIOR IN DIFFERENT JOINT ENVIROMENTS TO DEVELOP POTENCY ASSAYS STRATEGIC FOR CLINICAL APPLICATION IN RHEUMATIC DISEASES RIZZOLI Lisignoli Gina Biomedica Musculoskeletal, Oral and Skin Sciences Skeletal Biology Structure and Regeneration ‐ SBSR RF‐2013‐ 02355580 Role of GALNT2 on insulin resistance and glucose homeostasis CASA SOLLIEVO SOFFERENZA Di Paola Rosa Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular Aspects of Diabetes and Obesity ‐ CADO RF‐2013‐ 02355584 Therapeutic exploitation of correlates of melanoma cell resistance to targeted drugs through immunobiologic approaches C.R.O. AVIANO Sigalotti Luca Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT RF‐2013‐ 02355587 NEW THERAPEUTIC STRATEGIES TO IMPROVE T CELL FUNCTION BY TARGETING CO‐INHIBITORY RECEPTORS BY SMALL SYNTHETIC BLOCKING COMPOUNDS IN CHRONIC VIRAL INFECTIONS Emilia‐Romagna PENNA AMALIA Biomedica Immunology Immunity and Host Defense ‐ IHD RF‐2013‐ 02355588 ASSESSMENT OF NEOPLASTIC CONTAMINATION IN CRYOPRESERVED OVARIAN TISSUE OF PATIENTS AFFECTED BY SARCOMAS AND HEMATOLOGICAL MALIGNANT DISEASES: SAFETY OF TISSUE AUTOTRANSPLANTATION Emilia‐Romagna Fabbri Raffaella Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02355594 Sexual orientation as a social determinant of health: non‐ genetic predictors, quality of life, health status, and burden of selected mental and non‐mental health disorders among young adults in Friuli Venezia Giulia. Friuli‐Venezia Giulia Valent Francesca Clinico‐ Population Sciences and assistenzial Epidemiology e Social Sciences and Population Studies ‐ SSPS RF‐2013‐ 02355595 Role of sirtuin‐3 and its modulation in diabetic vascular disease: insights from clinical and preclinical approaches Veneto Avogaro Angelo Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Molecular and Cellular Endocrinology ‐ MCE RF‐2013‐ 02355596 Analysis of EMT‐like behaviour of hematopoietic cells expressing the leukemogenic fusion protein AML1/ETO. I.E.O. ALCALAY MYRIAM Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 211 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355601 ROLE OF THE NEUROTROPHIN BDNF AND ITS INTERACTION WITH ENVIRONMENTAL FACTORS IN THE REGULATION OF THROMBOSIS RF‐2013‐ 02355608 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Barbieri Silvia Stella Biomedica Event‐based modelling of Alzheimer's disease progression SANTA LUCIA to assist clinicians in the early diagnosis and prognosis on a single patient scale Giulietti Giovanni Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02355620 Targeting Endothelin‐1/YAP signaling to circumvent chemoresistance in ovarian cancer REGINA ELENA Bagnato Anna Teresa Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT RF‐2013‐ 02355624 PI3Kgamma at the intersection between hypertension and immune system. NEUROMED Maffei Angelo Biomedica Vascular and Hematology Hypertension and Microcirculation ‐ HM RF‐2013‐ 02355626 Toward a prenatal non‐invasive diagnosis of Congenital Heart Diseases (CHDs): identification of early plasmatic markers (miRNAs) Lazio GRAMMATIC PAOLA O Biomedica Genes, Genomes and Genetics Therapeutic Approaches to Genetic Diseases ‐ TAG RF‐2013‐ 02355630 Age related Macular Degeneration: analysis of gene expression in the Retina‐Pigment epithelium‐Choroid complex from human donors and validation of newly identified genes in diseased patients. Veneto FERRARI STEFANO Biomedica Genes, Genomes and Genetics Genomics, Computational Biology and Technology ‐ GCAT RF‐2013‐ 02355633 From migraine to Medication Overuse: environmental, clinical and molecular risk stratification for predicting migraine progression and for planning of prevention strategies. Istituto Scienze Neurologiche Cevoli Sabina Biomedica Brain Disorders and Clinical Neuroscience Neural Basis of Psychopathology, Addictions and Sleep Disorders ‐ NPAS RF‐2013‐ 02355634 ISTITUTO Pathogenetic role of endothelial cells in psoriasis: identification of therapeutic targets and predictive factors DERMOPATICO DELL'IMMACOLATA of co‐morbidities Failla Cristina Maria Biomedica Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ‐ ACTS RF‐2013‐ 02355647 A retrospective epidemiological evaluation of Multiple Sclerosis in Umbria Sarchielli Paola Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e MONZINO Umbria Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Vascular and Hematology Hemostasis and Thrombosis ‐ HT Clinical Neuroimmunology and Brain Tumors ‐ CNBT Pagina 212 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355649 Androgen excess, hormonal receptors, aromatase and 5alfa‐reductase activity, in breast cancer growth and prognosis RF‐2013‐ 02355653 Lazio Study of the effect of intravenous immunoglobulin therapy on T‐cell repertoire in AChR‐positive Myasthenia Gravis as a model for personalized medicine RF‐2013‐ 02355654 Anthropometric, metabolic, inflammatory and central haemodynamic parameters associated to newly diagnosed hypertension, inadequately controlled blood pressare and vascular aging in a large sample of general population: therapeutic and prognostic implicati RF‐2013‐ 02355656 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Venturelli Elisabetta Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS Bartoccioni Emanuela Biomedica Immunology Hypersensitivity, Autoimmune, and Immune Borghi Claudio Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS Red orange juice daily consumption and human health: a Istituto Superiore di Sanita' MASELLA pilot study in high cardio‐metabolic risk subjects and Type 2 Diabetic patients ROBERTA Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative Nutrition and Metabolic Processes ‐ INMP RF‐2013‐ 02355659 Nanoformulated antiretroviral drug for HIV eradication from sanctuary sites CORSI FABIO RUGGERO Biomedica AIDS and Related Research AIDS Discovery and Development of Therapeutics ‐ ADDT RF‐2013‐ 02355672 Lazio Identification and evaluation of non‐celiac gluten sensitivity by morphologic and functional magnetic resonance imaging using dynamic contrast enhanced and diffusion weighted imaging methods in comparison with a basic immunological study Masselli Gabriele Biomedica Immunology Hypersensitivity, Autoimmune, and Immune RF‐2013‐ 02355677 Identification of signalling pathway activation profiles in colorectal cancer stem cells by mass cytometry and correlation with sensitivity to pathway‐targeting drugs. Istituto Superiore di Sanita' Biffoni Mauro Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB RF‐2013‐ 02355678 Autoreactive memory stem T cells generation and expansion post islet transplantation SAN RAFFAELE MILANO Paolo Biomedica Immunology Transplantation, Tolerance and Tumor Immunology ‐ TTT ISTITUTO TUMORI MILANO Emilia‐Romagna Lombardia Monti Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 213 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355680 PREDICTIVE GENETIC ALTERATIONS IN OVARIAN CANCER (PREGIO) Emilia‐Romagna RF‐2013‐ 02355682 Calcitonin oligomers as a model to study the amyloid neurotoxicity: the focal role played by lipid rafts in the prevention and cure. RF‐2013‐ 02355684 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Daniela Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS Istituto Superiore di Sanita' Diociaiuti Marco Biomedica Biological Chemistry and Macromolecular Biophysics Biochemistry and Biophysics of Membranes ‐ BBM Optimization of cardiac stem cell replicative capacity in preclinical and clinical models of ischemic cardiomyopathy. SAN RAFFAELE PISANA LIMANA FEDERICA Biomedica Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF RF‐2013‐ 02355686 Innovative targeted therapy for the treatment of B cell leukemia BURLO GAROFALO Zauli Giorgio Biomedica Oncology 2 ‐ Translational Clinical Developmental Therapeutics ‐ DT RF‐2013‐ 02355688 BONE, FATTY TISSUE AND CARDIOVASCULAR SYSTEM: STUDY OF INTERACTIONS AMONG THREE SYSTEMS IN OBESE CHILDREN Puglia Faienza Maria Felicia Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO RF‐2013‐ 02355690 Complications in spinal surgery are too high. A prospective monitoring to reduce and avoid them. RIZZOLI Barbanti Brodano Giovanni Clinico‐ Risk, Prevention and assistenzial Health Behavior e Behavioral Medicine: Interventions and Outcomes ‐ BMIO RF‐2013‐ 02355692 PREDICTIVE SERUM EPIGENETICS IN HEAD AND NECK CANCER Piemonte Merlano Marco Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02355695 Pharmacological targeting of brain 5HT7 receptor to rescue molecular, morphofunctional and behavioral deficits in preclinical models of Rett Syndrome Istituto Superiore di Sanita' Laviola Giovanni Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD RF‐2013‐ 02355701 IDENTIFICATION OF GENETIC VARIANTS SAN RAFFAELE MILANO UNDERLYING BRONCHOPULMONARY DYSPLASIA IN PRETERM NEWBORNS USING EXOME SEQUENCING AND CORRELATION TO THE CLINICAL PHENOTYPE Carrera Paola Biomedica Cardiovascular and Respiratory Sciences Lung Injury, Repair, and Remodeling ‐ LIRR RF‐2013‐ 02355702 C.R.O. AVIANO Study the repurposed drug Auranofin to find new low cost therapeutic strategy for cancer patients negative and positive for HIV‐infection Aldinucci Donatella Biomedica Oncology 2 ‐ Translational Clinical Developmental Therapeutics ‐ DT Turchetti Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 214 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355704 Inhibition of endocannabinoids‐hydrolyzing enzymes as a new therapeutic target for migrainetreatment: studies in animal models and preliminary evaluation in humans RF‐2013‐ 02355706 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Tassorelli Cristina Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN CASA SOLLIEVO Defining the Combinatorial Suppression of human SOFFERENZA Glioblastoma Cancer stem‐like cells (hGSCs) by the neurogenic niche effectors Ephrins and BMPs. Improving hGSCs enrichment and seeking new hGSC‐specific regulators and novel therapeutic options. Vescovi Angelo Luigi Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP RF‐2013‐ 02355711 Treatment of Subsyndromal Delirium and Long term Cognitive Dysfunction after Cardiac surgery. Predictive value of Neurobiochemical Markers of brain injury and Resting State Functional Connectivity evaluation Emilia‐Romagna vezzani antonella Clinico‐ Integrative, Functional, assistenzial and Cognitive Neuroscience e Cognitive Neuroscience ‐ COG RF‐2013‐ 02355715 Ghrelin as a new cardiometabolic risk biomarker: from population and patient studies to tissue and cell biology in heart and skeletal muscle. Friuli‐Venezia Giulia Barazzoni Rocco Biomedica Clinical and Integrative Diabetes and Obesity ‐ CIDO RF‐2013‐ 02355716 Impact of Diabetes on the Regenerative Potential of the Human Renal Glomerulus. SAN RAFFAELE MILANO Zerbini Gianpaolo Clinico‐ Biology of Development assistenzial and Aging e Cellular Mechanisms in Aging and Development ‐ CMAD RF‐2013‐ 02355727 Pathological biomineralization: new insights in human bioapatite deposits in the calcific aortic valve and aortic wall in the prevention of early calcification Veneto Viscardi Francesca Biomedica Cardiovascular and Respiratory Sciences Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR RF‐2013‐ 02355729 Innate immune responses in Multiple Sclerosis SANTA LUCIA BORSELLINO GIOVANNA Biomedica Immunology Innate Immunity And Inflammation ‐ III RF‐2013‐ 02355735 Non‐traditional biomarkers of CKD‐associated cardiovascular disease: potential new avenues for prevention and therapy. Campania Perna Biomedica Digestive, Kidney and Urological Systems Pathobiology of Kidney Disease ‐ PBKD MONDINO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Alessandra Endocrinology, Metabolism, Nutrition and Reproductive Sciences Pagina 215 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355736 THE ROLE OF SOD1 IN THE NUCLEUS: NEW INSIGHTS MONDINO INTO THE PATHOGENESIS OF AMYOTROPHIC LATERAL SCLEROSIS (ALS). Cereda Cristina Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND RF‐2013‐ 02355738 ErbB receptors and TGF‐beta crosstalk in H.pylori related Abruzzo in gastric diseases: molecular signalling and therapeutic opportunities Innocenti Paolo Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP RF‐2013‐ 02355740 Therapeutic targeting of cancer stem cells and identification of biomarkers predictive of drug‐response in lung cancers Istituto Superiore di Sanita' Eramo Adriana Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT RF‐2013‐ 02355741 SCREENING FOR OSTEOPOROSIS AND FRACTURE RISK: TARGETING THE LINK BETWEEN CIRCULATING MONOCYTES AND BONE REMODELING RIZZOLI Fini Milena Clinico‐ Musculoskeletal, Oral and assistenzial Skin Sciences e Musculoskeletal, Oral and Skin Sciences Small Business ‐ SEMO RF‐2013‐ 02355742 RIZZOLI Pathogenesis and control of osteomyelitis in periprosthetic infections. Innate immune defense against biofilm and design of anti‐infective biomaterials Arciola Carla Renata Biomedica Infectious Diseases and Microbiology Bacterial Pathogenesis ‐ BACP RF‐2013‐ 02355745 Hydrogen Sulfide role in the inflammatory response in Amyotrophic Lateral Sclerosis Spalloni Alida Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN RF‐2013‐ 02355748 Role of autophagy in growth, progression and endothelial GASLINI trans‐differentiation of neuroblastoma cells Pezzolo Annalisa Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME RF‐2013‐ 02355749 IZSPLV HUMANS AND WILDLIFE: ZOOS IN BETWEEN. ARE ZOOS A THREAT OR BIOSENTINELS FOR INFECTIOUS DISEASES? Acutis Pier Luigi Biomedica Veterinary Animal Health ‐ ANHE RF‐2013‐ 02355750 Analysis of the clinico‐pathological and prognostic value of defects in transcriptional regulation of ovarian cancer Bignotti Eliana Biomedica Oncology 1 ‐ Basic Translational Tumor Progression and Metastasis ‐ TPM2 SANTA LUCIA Lombardia Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 216 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355753 APPLICATIONS OF X‐RAY FLUORESCENCE BASED TECHNIQUES AND ADVANCED IMAGING METHODS TO UNRAVEL CHANGES IN IRON METABOLISM AND METAL TOXICITY IN CHILDREN BURLO GAROFALO RF‐2013‐ 02355754 Assessment of the risk for consumers exposed to industrial, urban and agricultural environmental contaminants deriving from the illegal disposal of wastes within the ¿Land of Fire¿ (Campania Region) RF‐2013‐ 02355764 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Lorella Biomedica Biological Chemistry and Macromolecular Biophysics Enabling Bioanalytical and Biophysical Technologies ‐ EBT Istituto Superiore di Sanita' Ferrara Fulvio Biomedica Veterinary Food Safety ‐ FOSA ALS and FTD: changing paradigms in the genotype‐ phenotype correlation due to C9orf72 and other gene characterization AUXOLOGICO Vincenzo Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02355768 THE IMPACT OF INTENSIVE TUBERCULOSIS CASE FINDING WITH MOLECULAR TESTS IN HIV‐ INFECTED PATIENTS Istituto Superiore di Sanita' Giuliano Marina Clinico‐ AIDS and Related Research assistenzial e AIDS Clinical Studies and Epidemiology ‐ ACE RF‐2013‐ 02355777 Proteostasis modulation as a novel therapeutic strategy for cystic fibrosis. GASLINI Pedemonte Nicoletta Biomedica Genes, Genomes and Genetics Therapeutic Approaches to Genetic Diseases ‐ TAG RF‐2013‐ 02355782 A new strategy against neurodegeneration: pharmacological modulation of the Ca2+ permeability of ionotropic glutamate receptors NEUROMED Fucile Sergio Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN RF‐2013‐ 02355800 Sodium calcium exchanger (NCX): a new player in neuronal degeneration occurring in Parkinson's Disease SDN Sirabella Rossana Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND RF‐2013‐ 02355805 Phase 1‐2 study of valproic acid combined with radiotherapy and chemotherapy in locally advanced non‐ small‐cell lung cancer (V‐LANCE study) PASCALE Morabito Alessandro Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Pascolo Silani Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Clinical Oncology ‐ CONC Pagina 217 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE Classificazione 1 Liv. Classificazione 2° liv. RF‐2013‐ 02355807 mTOR inhibition and cardiovascular aging in chronic kidney disease Puglia Stallone Giovanni Biomedica Cardiovascular and Respiratory Sciences Clinical and Integrative Cardiovascular Sciences ‐ CICS RF‐2013‐ 02355809 Pharmacological Targeting of the new GPR17 receptor to prevent adverse remodeling and heart failure in the ischemic heart MONZINO Sironi Luigi Biomedica Cardiovascular and Respiratory Sciences Myocardial Ischemia and Metabolism ‐ MIM RF‐2013‐ 02355818 Toscana METABOHEARTFAIL‐GRAPE miRNAs IN REVERSING REMODELING THROUGH MODULATION OF CARDIAC AQUAPORIN‐7 AND GLYCEROL UPTAKE IN A SWINE MODEL OF NON‐ISCHEMIC CHRONIC HEART FAILURE Lionetti Vincenzo Biomedica Cardiovascular and Respiratory Sciences Myocardial Ischemia and Metabolism ‐ MIM RF‐2013‐ 02355819 Abruzzo An integrated genomic and proteomic approach for cancer screening and targeted therapy in early stage lung adenocarcinoma BUTTITTA FIAMMA Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02355823 A marker‐based approach to multimodal esophageal cancer treatment I. O. V. Scarpa Marco Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02355824 Development of anti‐giardial drugs targeting g14‐3‐3 interactions. Istituto Superiore di Sanita' Lalle Marco Biomedica Infectious Diseases and Microbiology Drug Discovery and Mechanisms of Antimicrobial Resistance ‐ DDR RF‐2013‐ 02355825 USING VIRTUAL REALITY AND ROBOTICS REHABILITATION INTERVENTION TO IMPROVE SOCIAL AND COGNITIVE ABILITY IN ADOLESCENTS AND CHILDREN WITH AUTISM Abruzzo Valenti Marco Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Developmental Brain Disorders ‐ DBD RF‐2013‐ 02355831 Instrumental Learning of Anterior Insular Cortex Activity S.CAMILLO with Real‐time fMRI in AutismSpectrum Disorders. Caria Andrea Biomedica Developmental Brain Disorders ‐ DBD Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Brain Disorders and Clinical Neuroscience Pagina 218 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE Classificazione 1 Liv. Classificazione 2° liv. RF‐2013‐ 02355834 Validation of Next Generation Sequencing (NGS)‐based Lysosomal Storage Disease Diagnostic Panels and Characterisation of Novel Gene Variants by Functional Studies through Transient Generation of Zebrafish Mutants GASLINI Filocamo Mirella Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD RF‐2013‐ 02355835 What makes a maltreated child become an adult drug abuser: uncovering neuroimaging/blood biomarkers and designing rescue therapeutic strategies in preclinical models SANTA LUCIA carola valeria Biomedica Brain Disorders and Clinical Neuroscience Neural Basis of Psychopathology, Addictions and Sleep Disorders ‐ NPAS RF‐2013‐ 02355836 SAN RAFFAELE MILANO Mutational profile of HCV non structural regions (NS3, NS5a and NS5b) associated with direct acting antivirals resistance in HIV/HCV coinfected individuals naive or non responder to dual (Peg interferon plus ribavirin, P‐R) anti‐HCV treatment: possible i Bagaglio Sabrina Biomedica Infectious Diseases and Microbiology Clinical Research and Field Studies of Infectious Diseases ‐ CRFS RF‐2013‐ 02355841 Exploiting Rho GTPase signaling: a novel therapeutic avenue in the treatment of Fragile X Syndrome Istituto Superiore di Sanita' Diana Giovanni Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD RF‐2013‐ 02355856 Human neural stem/progenitor cells derived from induced pluripotent stem cells (hiNSCs) as a renewable source of transplantable neurons and oligodendrocytes. SAN RAFFAELE MILANO Gritti Angela Biomedica Molecular, Cellular, and Developmental Neuroscience Neurogenesis and Cell Fate ‐ NCF RF‐2013‐ 02355863 Cervical cancer screening in younger women. Piemonte Ronco Guglielmo Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02355866 Towards the definition of molecular alterations characteristic of indolent prostate cancer: Implications for improved selection of active surveillance patients ISTITUTO TUMORI MILANO Valdagni Riccardo Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02355867 Evaluation of new approaches for prevention and control Istituto Superiore di Sanita' ricci of Legionella and other waterborne pathogens through the analysis of microbiome of drinking water systems. maria luisa Biomedica Infectious Diseases and Microbiology Fellowship ‐ F13 Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Infectious Diseases and Microbiology Pagina 219 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355868 Chromosome 17 gene amplification hotspots as biomarkers and therapeutic targets for aggressive breast cancer. I.E.O. DI FIORE PIER PAOLO Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC RF‐2013‐ 02355871 Cell‐free DNA methylated sequences in coronary artery disease: role as new potential pathophysiologic markers SAN DONATO Corsi Romanelli Massimiliano Marco Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD RF‐2013‐ 02355872 Circulating microRNAs as biomarkers for diagnosis and prognosis of hepatocellular and cholangiocellular carcinomas Emilia‐Romagna Gramantieri Laura Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02355874 MULTICENTRIC RANDOMIZED PHASE II TRIAL OF TRANSORAL ROBOTIC SURGERY (TORS) FOLLOWED BY RISK‐BASED DEINTENSIFIED RADIOTHERAPY VERSUS DEINTENSIFIED CURATIVE RADIOCHEMOTHERAPY FOR T1‐T2 WITH MINIMAL NODAL INVOLVMENT HPV POSITIVE OROPHARYNX CANCER I.E.O. alterio daniela Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Radiation Therapeutics and Biology ‐ RTB RF‐2013‐ 02355877 Otoacoustic emissions as biomarkers of possible synergistic interaction in inducing hearing damage: an experimental study INAIL Sisto Renata Biomedica Population Sciences and Epidemiology Neurological, Aging and Musculoskeletal Epidemiology ‐ NAME RF‐2013‐ 02355880 Targeted genome editing in Recombination activating gene (RAG) 1: precise correction of the genetic defect in human SCID. HUMANITAS Villa Anna Biomedica Immunology Cellular and Molecular Immunology B ‐ CMIB RF‐2013‐ 02355883 Evaluation of changes of fecal microbioma in patients infected/colonized with Klebsiella pneumoniae carbapenames producers (KPC‐Kp) after the use of decontamination protocols SPALLANZANI D'arezzo Silvia Biomedica Infectious Diseases and Microbiology Clinical Research and Field Studies of Infectious Diseases ‐ CRFS RF‐2013‐ 02355884 Pathogenetic aspects of ebolavirus infection SPALLANZANI Di Caro Antonino Biomedica Infectious Diseases and Microbiology Virology A and B Study Sections ‐ VIRA and VIRB Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 220 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355885 Innovative HDACi/IFN‐alpha‐based combination therapy Istituto Superiore di Sanita' Gabriele in solid tumors RF‐2013‐ 02355888 REGENERATIVE THERAPY OF OSTEOCHONDRAL LESIONS: FACTORS THAT INFLUENCE CELLULAR MEDICINE RIZZOLI RF‐2013‐ 02355889 CDKL5 RARE DISEASE: CHARACTERIZATION OF THE DISORDER AND DEVELOPMENT OF THERAPEUTIC STRATEGIES RF‐2013‐ 02355891 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Lucia Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT Buda Roberto Biomedica Bioengineering Sciences and Technologies Biomaterials and Biointerfaces ‐ BMBI Istituto Scienze Neurologiche Gobbi Giuseppe Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD QUANTITATIVE MRI OF THE BRAIN AND SPINAL CORD FOR THE EVALUATION OF ADRENOMYELONEUROPATHY SEVERITY AND PROGRESSION SAN RAFFAELE MILANO Politi Letterio Salvatore Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Medical Imaging ‐ MEDI RF‐2013‐ 02355893 Preventing mental retardation in two intermediate metabolism diseases: a preclinical investigation for new therapy SANTA LUCIA Puglisi‐Allegra Stefano Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD RF‐2013‐ 02355896 Istituto Superiore di Sanita' Alano Functional dissection of the bone marrow privileged maturation niche of Plasmodium falciparum transmission stages in a humanized mouse model Pietro Biomedica Infectious Diseases and Microbiology Infectious Diseases and Microbiology Fellowship ‐ F13 RF‐2013‐ 02355898 Establishment of an Italian cohort study of psoriasis and Lombardia psoriatic arthritis based on record‐linkage of regional healthcare administrative databases, and assessment of the risk of severe infections, major cardiovascular events, and cancer, in patients tr Naldi Luigi Clinico‐ Healthcare Delivery and assistenzial Methodologies e Biostatistical Methods and Research Design ‐ BMRD RF‐2013‐ 02355899 Healthy Math S.CAMILLO Semenza Carlo Clinico‐ Biobehavioral and assistenzial Behavioral Processes e Cognition and Perception ‐ CP RF‐2013‐ 02355903 Use of meropenem in critically ill patients with gram negative infections. A multicenter randomized study. SAN RAFFAELE MILANO Colombo Sergio Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 221 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355904 SANTA LUCIA Role of the interaction between neurotensin and metabotropic glutamate receptors at cellular level: possible involvement in the development and expression of levodopa‐induced dyskinesia. RF‐2013‐ 02355908 Idiopathic Normal Pressure Hydrocephalus (iNPH), parkinsonism and dementia: improving the accuracy of diagnosis and the patient care to reverse the symptomatology Neurodegeneration, Phenotypes and Outcome Measures RF‐2013‐ 02355920 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Guatteo Ezia Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN MONDINO Pacchetti Claudio Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN Ciliogeneisis and sonic hedgehog signaling in Niemann Pick type C disease: possible role in disease pathogenesis. Friuli‐Venezia Giulia Dardis Andrea Elena Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN RF‐2013‐ 02355923 PENETRATION OF METAL NANOPARTICLES THROUGH BIOLOGICAL MEMBRANES AND IMMUNOLOGICAL RESPONSE Friuli‐Venezia Giulia Bovenzi Massimo Biomedica Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ‐ ACTS RF‐2013‐ 02355929 Role of miRNA/mRNA network and mesenchymal Campania stromal cells in the pathogenesis of the aortopathy associated with bicuspid and tricuspid aortic valve and as early biomarkers Cipollaro Marilena Biomedica Cardiovascular and Respiratory Sciences Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR RF‐2013‐ 02355931 Linking metagenomic and metabolomics profiling of the SAN RAFFAELE MILANO human intestinal microbiota to gut immune alterations in autoimmune Type 1 Diabetes Falcone Marika Biomedica Immunology Hypersensitivity, Autoimmune, and Immune RF‐2013‐ 02355934 Next generation sequencing in Neural Tube Defects: identification of susceptibility genes in order to improve prevention and genetic counseling Capra Valeria Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD RF‐2013‐ 02355937 EVALUATION OF STANDARD VIDEODERMATOSCOPY Sicilia AND LOW‐COST VIDEOMICROSCOPES AS NON‐ INVASIVE DIAGNOSTIC TOOLS FOR SCABIES AND OTHER SKIN ECTOPARASITOSES OF THE MIGRANTS: A COST EFFECTIVE ANALYSIS Micali Giuseppe Clinico‐ Infectious Diseases and assistenzial Microbiology e GASLINI Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Clinical Research and Field Studies of Infectious Diseases ‐ CRFS Pagina 222 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355940 Epigenetic/somatic alterations and inter‐cellular nucleic I.N.R.C.A. acids transfer associated with an impaired control of endogenous retrotransposable elements in breast cancer: a study to investigate pathogenic mechanisms, new prognostic disease markers and experi Cardelli Maurizio Biomedica RF‐2013‐ 02355941 New strategies for personalized diagnosis and treatment of nephrotic syndrome in children. Toscana Romagnani Paola Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Pathobiology of Kidney Disease ‐ PBKD RF‐2013‐ 02355943 Effects of an endoscopic technique, the duodenal‐jejunal bypass liner, on body weight, glyco‐metabolic control and some adipocytokines in type 2 diabetic patients SAN MATTEO Derosa Giuseppe Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO RF‐2013‐ 02355949 Multicenter phase II clinical study of adoptive Emilia‐Romagna immunotherapy with alloreactive NK cells as consolidation strategy for elderly acute myeloid leukemia patients Curti Antonio Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Immunopathology and Immunotherapy ‐ CII RF‐2013‐ 02355950 The morphometric study of nerve: super‐resolution Mosaicing analysis (PNS‐MoMa) SAN RAFFAELE MILANO Sanguigno Luigi Biomedica Bioengineering Sciences and Technologies Biodata Management and Analysis ‐ BDMA RF‐2013‐ 02355952 Modulation of SHP2's allosteric regulation as a novel strategy to treat hematologic malignancies and RASopathies Istituto Superiore di Sanita' Martinelli Simone Biomedica Oncology 2 ‐ Translational Clinical Drug Discovery and Molecular Pharmacology ‐ DMP RF‐2013‐ 02355962 Ser/Thr protein phosphatases as potentially druggable biomarkers to predict trastuzumab therapeutic responsiveness, and counteract the development of resistance in breast cancer SAN RAFFAELE MILANO TACCHETTI CARLO Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB RF‐2013‐ 02355963 The use of classical conditioning with a telemedicine approach for anomia rehabilitation in chronic aphasia: a clinical outcome research SANTA LUCIA Carlesimo Giovanni Augusto Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD Clinical Neuroscience and Neurodegeneration ‐ CNN Pagina 223 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02355971 Pre‐clinical and clinical (phase I) investigation on the role Lombardia of umbilical cord wall derived mesenchymal stromal cells (UC‐MSC) to treat severe grade III/IV steroid resistant acute graft versus host disease (GVHD) introna martino Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Immunopathology and Immunotherapy ‐ CII RF‐2013‐ 02355975 Glycosaminoglycans as critical players in inflammation and tissue damage during chronic lung infection by Pseudomonas aeruginosa: prognostic and therapeutic implications for cystic fibrosis SAN RAFFAELE MILANO Cigana Cristina Biomedica Host Interactions with Bacterial Pathogens ‐ HIBP RF‐2013‐ 02355987 Antenatal human heart development Lombardia cuttin maria serena Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Cardiovascular Differentiation and Development ‐ CDD RF‐2013‐ 02355989 Development of novel biomarkers for the early diagnosis of chronic antibody mediated rejection in renal transplantation Veneto Zaza Gianluigi Biomedica Pathobiology of Kidney Disease ‐ PBKD RF‐2013‐ 02355992 Outcomes and cost of care in diabetic subjects over 70 I.N.R.C.A. years old living in Regione Marche (Italy): results from a record‐linkage analysis of administrative and clinical data between 2008 and 2012 Rabini Rosa Anna Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02355999 Hippocampal‐mesolimbic network dysfunction: a vicious SANTA LUCIA worsening loop of cognitive decline in Alzheimer's disease? A molecular, electrophysiological and behavioral investigation on a murine model Berretta Nicola Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroplasticity and Neurotransmitters ‐ CNNT RF‐2013‐ 02356001 ERK5 and Hedgehog pathways as novel targets for melanoma treatment Toscana Stecca Barbara Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT RF‐2013‐ 02356002 Targeting of lysophosphatidic acid‐mediated autocrine/paracrine growth signal as novel therapeutic approach for liver cancer DE BELLIS Mazzocca Antonio Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Infectious Diseases and Microbiology Digestive, Kidney and Urological Systems Pagina 224 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02356003 FECAL MICROBIAL TRANSPLANTATION IN HIV‐ INFECTED PATIENTS WITH SUB OPTIMAL IMMUNOLOGICAL RESPONSE UNDER ANTIRETROVIRAL THERAPY Lombardia BANDERA ALESSANDRA Biomedica RF‐2013‐ 02356005 CONTROLLED PHYSICAL ACTIVITY, WELLNESS EDUCATION AND ACTIVE AGINGA cohort study on cardiovascular and hemodynamic responses to physical activity in the elderly. Lazio legramante jacopo maria Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR RF‐2013‐ 02356006 Prostate Cancer Surveillance: a new strategy to select and Istituto Oncologico Candiolo monitor patients using repeated PSA test and Magnetic Resonance Imaging Regge Daniele Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Medical Imaging ‐ MEDI RF‐2013‐ 02356015 Digging deeper into molecular mechanisms of bcl‐2‐ mediated regulation of different functions in melanoma REGINA ELENA Del Bufalo Donatella Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB RF‐2013‐ 02356017 Inside the mechanism of immune disregulation due to EBV infection in MS SANTA LUCIA Angelini Daniela Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT RF‐2013‐ 02356020 Exploring the molecular mechanisms of glioblastoma Istituto Superiore di Sanita' Ricci Vitiani stem‐like cell survival and differentiation to design novel therapeutic strategies: microRNAs as potential supporters to tumor vascularization Lucia Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB RF‐2013‐ 02356024 Targeting HMGB1 with BoxA in inflammation‐associated cancer Bianchi Marco E. Biomedica Oncology 2 ‐ Translational Clinical Developmental Therapeutics ‐ DT RF‐2013‐ 02356027 Implementation and sustainability of a systems medicine Toscana approach in patients affected by cardiovascular disease and dysmetabolic status. Gensini Gian Franco Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e SAN RAFFAELE MILANO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. AIDS and Related Research AIDS Discovery and Development of Therapeutics ‐ ADDT Clinical and Integrative Cardiovascular Sciences ‐ CICS Pagina 225 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02356030 Sardegna KILLER IMMUNOGLOBULIN LIKE RECEPTOR AND HUMAN ENDOGENOUS RETROVIRUS K (HERVK) AS TUMOR BIOMARKERS OF ONCOGENESIS AND RESPONSE TO TREATMENT IN ONCO‐HEMATOLOGY RF‐2013‐ 02356036 Innovative testing of bone substitute bioavailability for oral surgery procedure. RF‐2013‐ 02356049 Non invasive brain stimulation in rehabilitation of Sicilia neurological and cognitive defects in post‐stroke patients. RF‐2013‐ 02356054 Non coding RNA Signatures: Novel Biomarkers for early detection of Colorectal Cancer RF‐2013‐ 02356058 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. GIORGIO Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS Rossella Biomedica Oral, Dental and Craniofacial Sciences ‐ ODCS fierro brigida Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Brain Injury and Neurovascular Pathologies ‐ BINP CASA SOLLIEVO SOFFERENZA Piepoli Ada Biomedica Cancer Biomarkers ‐ CBSS EVALUATING AND RANKING PATIENT‐ORIENTED OUTCOME MEASURES IN BRAIN TUMOR PATIENTS WITH EVIDENCE‐BASED CRITERIA Veneto Talacchi Andrea Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC RF‐2013‐ 02356059 Development of an immunotherapeutic strategy for an effective therapeutic HPV vaccine Istituto Superiore di Sanita' NEGRI DONATELLA Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII RF‐2013‐ 02356061 Non‐melanoma skin cancers and inflammation: Roles of NF‐kB‐regulated Gadd45b gene Abruzzo Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP RF‐2013‐ 02356063 Attacking amyotrophic lateral sclerosis from the Istituto Superiore di Sanita' Potenza periphery: will the immune system help to win the battle? Rosa Luisa Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN RF‐2013‐ 02356068 Preclinical and clinical study on Schizophrenia‐Bipolar Disorder Spectrum (SZ‐BPDs) and Frontotemporal Dementia (FTD) shared genetic and neurobiological profile Giulia Biomedica Brain Disorders and Clinical Neuroscience Pathophysiological Basis of Mental Disorders and Addictions ‐ PMDA LA NASA Istituto Superiore di Sanita' Bedini Veneto Fargnoli Perini Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Maria Concetta Biomedica Musculoskeletal, Oral and Skin Sciences Oncology 2 ‐ Translational Clinical Pagina 226 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02356070 SEARCHING NEW DIAGNOSTIC/PROGNOSTIC MARKERS OF CANDIDEMIA Istituto Superiore di Sanita' Torosantucci RF‐2013‐ 02356071 The role of Hedgehog pathway in the cerebellar functionality and resilience SANTA LUCIA RF‐2013‐ 02356072 Genetic markers in elderly to estimate the risk for vascular diseases by using the peripheral arterial disease model. RF‐2013‐ 02356074 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Antonella Biomedica Infectious Diseases and Microbiology Clinical Research and Field Studies of Infectious Diseases ‐ CRFS Petrosini Laura Biomedica Biobehavioral and Behavioral Processes Biobehavioral Regulation, Learning and Ethology ‐ BRLE Sicilia Signorelli Salvatore Santo Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD OPA1‐related blindness in Italy: from genotype to phenotype to disease modelling, towards a therapy Istituto Scienze Neurologiche Carelli Valerio Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02356077 Childhood Cancer Survivors entering adulthood: prevalence of chronic conditions and the Survivorship Passport as a tool for transition to adult care and follow‐ up GASLINI Haupt Riccardo Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02356081 Italian Platform on Neurodegenerative Disorders of Aging. A Meta‐Database of Italian Cohort studies SANTA LUCIA Musicco Massimo Clinico‐ Integrative, Functional, assistenzial and Cognitive Neuroscience e Neurobiology of Learning and Memory ‐ LAM RF‐2013‐ 02356083 Serum Cholesterol efflux capacity (CEC) as an index of plaque vulnerability in patients with carotid atherosclerosis: correlation with embolic potential evaluated by trans‐cranial Doppler (TCD) Emilia‐Romagna Denti Licia Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS RF‐2013‐ 02356106 Modulating the dynamic molecular interplay between carnosine‐like peptides, metal ions and aberrant ß‐ amyloid peptides in CNS and in Alzheimer's Disease: integrated model approach for counteracting neurodegeneration SAN RAFFAELE MILANO Barca Amilcare Biomedica Cellular and Molecular Biology of Neurodegeneration ‐ CMND Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Molecular, Cellular, and Developmental Neuroscience Pagina 227 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO RF‐2013‐ 02356107 Safety and effectiveness of a new exoskeletal robotic device for hand motor recovery after stroke. RF‐2013‐ 02356111 DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Toscana Posteraro Federico Biomedica BIETTI Oddone Francesco Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Anterior Eye Disease ‐ AED Proteomic analysis of tears of patients with glaucomatous optic neuropathy: pointing towards the development of novel diagnostic, prognostic and therapeutic strategies for glaucoma Bioengineering Sciences and Technologies Instrumentation and Systems Development ‐ ISD RF‐2013‐ 02356112 An addressed nutrigenetic approach to calcium nephrolithiasis SAN RAFFAELE MILANO Vezzoli Giuseppe Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Integrative Nutrition and Metabolic Processes ‐ INMP RF‐2013‐ 02356123 Epigenetic marks and inflammatory profile of subcutaneous adipose tissue in severely obese subjects before and after controlled caloric restriction and exercise training intervention. MAUGERI Rengo Franco Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular Aspects of Diabetes and Obesity ‐ CADO RF‐2013‐ 02356127 Deciphering the Systems Properties of the Mitochondrial SANTA LUCIA Proteome in Neurodegenerative Diseases Urbani Andrea Biomedica Molecular, Cellular, and Developmental Neuroscience Neural Oxidative Metabolism and Death ‐ NOMD RF‐2013‐ 02356135 Releasing the immune brakes to enhance the power of anticancer vaccines for the treatment of HER2+ cancer patients" Piemonte SATOLLI MARIA ANTONIETTA Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII RF‐2013‐ 02356136 The functional basis of cerebro‐cerebellar connectivity: implications for dysfunction in Alzheimer diseases MONDINO D'Angelo Egidio Biomedica Integrative, Functional, and Cognitive Neuroscience Neurobiology of Learning and Memory ‐ LAM RF‐2013‐ 02356139 "Stand and Walk". Optimizing the embodiment and agency of relevant robotic walkers in spinal cord injury patients SANTA LUCIA Pazzaglia Mariella Biomedica Bioengineering Sciences and Technologies Modeling and Analysis of Biological Systems ‐ MABS Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 228 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02356140 Istituto Superiore di Sanita' Butto HIV‐1 Env proteins variability in variants from different HIV‐1 subtypes and recombinant forms and its correlation with disease stage and resistance/sensitivity to neutralization. Stefano Biomedica AIDS and Related Research AIDS Immunology and Pathogenesis ‐ AIP RF‐2013‐ 02356141 Clinical and molecular characterization of corpus callosal Campania abnormalities: towards a better understanding of their genetic basis. Del Giudice Ennio Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD RF‐2013‐ 02356148 Adherence to Mediterranean Diet and pregnancy outcome: clinical, biochemical and epigenetic effects. Macchia Paolo Emidio Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular, Molecular and Integrative Reproduction ‐ CMIR RF‐2013‐ 02356151 Assessing the relevance of a target‐organ¿specific miRNA SAN RAFFAELE MILANO signature in type 1 diabetes and in other organ‐specific autoimmune diseases Battaglia Manuela Biomedica Immunology Hypersensitivity, Autoimmune, and Immune RF‐2013‐ 02356167 T cell response to anti‐TNF‐alpha therapeutical agents in Toscana treated patients to prevent loss of response and adverse drug reactions Maggi Enrico Biomedica Immunology Hypersensitivity, Autoimmune, and Immune RF‐2013‐ 02356168 GENOTYPE CHARACTERIZATION IN LIQUID BIOPSIES Lombardia FOR THE EARLY IDENTIFICATION OF LETHAL DISEASE IN PROSTATE CANCER PATIENTS WITH PSA PROGRESSION AFTER PRIMARY TREATMENT Berruti Alfredo Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02356169 Effects of different dietary fatty acids on non‐alcoholic fatty liver disease in patients with type 2 diabetes Campania Riccardi Gabriele Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO RF‐2013‐ 02356173 Bioreactor‐based recellularization of fixative‐free decellularized pericardium with aortic valve‐derived interstitial cells for derivation of living heart valve bioprostheses MONZINO Polvani Gianluca Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences ‐ BTSS Campania Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 229 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02356176 A multidisciplinary and integrated study of the behavioral, genetics and neurobiological correlates of impulsive and violent behavior. Implications for the development of rehabilitation strategies in convicted offenders. Toscana Pietrini Pietro Biomedica RF‐2013‐ 02356180 Refractory epilepsy or syncope incognito unmasked by exhaustive neurophysiologic and electrocardiographic investigations: a prospective, advanced diagnostic evaluation that may allow an early and alternative diagnosis in many patients with drug‐resistant Calabria Gambardella Antonio Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Acute Neural Injury and Epilepsy ‐ ANIE RF‐2013‐ 02356181 Botanicals used in products marketed for human and animal health: phytochemical profiles and their toxicity evaluation Istituto Superiore di Sanita' GALLO FRANCESCA ROMANA Biomedica SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan ‐ TPM1 RF‐2013‐ 02356184 We Need TYME: the Italian "hub and spoke" network for centralized clinical and translational research to ensure multidisciplinary expertise and to promote drug development and biomarker discovery for ThYmic MalignanciEs ISTITUTO TUMORI MILANO Garassino Marina Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC RF‐2013‐ 02356196 DNA global demethylation and specific somatic mutation Istituto Oncologico Candiolo patterns as potential biomarkers of risk for colorectal neoplasm. Venesio Tiziana Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02356197 Effects of sensory stimulation on cognitive performance in normal subjects and in brain‐injured patients: an ERP analysis Toscana Carboncini Maria Chiara Biomedica Integrative, Functional, and Cognitive Neuroscience Cognitive Neuroscience ‐ COG RF‐2013‐ 02356199 Genotype/phenotype correlation in retinitis pigmentosa: use of multiple animal models of photoreceptors degeneration to elucidate molecular mechanisms of disease and response to different therapies Lazio Falsini Benedetto Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Biobehavioral and Behavioral Processes Risk, Prevention and Health Behavior Biobehavioral Mechanisms of Emotion, Stress and Health ‐ MESH Pagina 230 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO RF‐2013‐ 02356201 Role of environment‐gene interaction in etiology and promotion of pituitary tumours. RF‐2013‐ 02356215 DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Cannavò Salvatore Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Molecular and Cellular Endocrinology ‐ MCE Cell‐type and subunit specific alterations of NMDA SANTA LUCIA receptors in striatum at early stages of Parkinson's disease Calabresi Paolo Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02356218 Oleuropein aglycone efficacy against Alzheimer's disease: an advanced biological preclinical investigation and a proof of concept study in mild Alzheimer's disease patients Toscana SORBI SANDRO Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02356221 Development of a nanoparticle‐based pharmacological approach for amyotrophic lateral sclerosis MARIO NEGRI Bigini Paolo Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02356224 Novel serum biomarkers of liver disease progression in obese patients with liver steatosis Sicilia Montalto Giuseppe Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative Physiology of Obesity and Diabetes ‐ IPOD RF‐2013‐ 02356230 How is it possible to define rehabilitation care appropriateness? The impact of an alternative evaluation system on the appropriateness of health care resources Emilia‐Romagna Brianti Rodolfo Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02356240 Exploring the phenotypic heterogeneity in E200K Creutzfeldt‐Jakob disease by integrated association studies: a model for improving the management of neurodegenerative diseases. Istituto Superiore di Sanita' Ladogana Anna Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02356241 Silk protein platform for efficient mimicking of the bone marrow vascular niche and functional platelet production: a translational research strategy to understand platelet related diseases and predict efficacy for candidate therapeutics SAN MATTEO ALESSANDRA Biomedica Bioengineering Sciences and Technologies Modeling and Analysis of Biological Systems ‐ MABS Sicilia BALDUINI Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 231 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02356245 P2X7 and cancer: a double‐edge sword GASLINI RF‐2013‐ 02356252 Evaluation of the vector competence of mosquito species within the Culicinae sub‐family for both circulating and importable arboviruses, and assessment of the potential exposure of animal and human populations to infected vectors in North‐Eastern Italy. Istituto Superiore di Sanita' Rezza RF‐2013‐ 02356259 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Danilo Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME Giovanni Biomedica Infectious Diseases and Microbiology Infectious Diseases and Microbiology Fellowship ‐ F13 Respiratory Syncytial Virus (RSV) infection in infants: the Istituto Superiore di Sanita' Ausiello Ectonet/IFNs axis as regulator of inflammatory/adaptive responses and as therapeutic target. Clara Maria Biomedica Immunology Innate Immunity And Inflammation ‐ III RF‐2013‐ 02356260 Targeted Next‐generation sequencing: implementation of Emilia‐Romagna a novel diagnostic tool in the clinical routine of newborn screening Simona Ferrari Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD RF‐2013‐ 02356270 Potential role of HDL Cholesterol Efflux Capacity in the evaluation of cardiovascular risk in patients with Familial Hypercholesterolemia (FH) IRCCS AOU San Martino‐ IST (Genova) pisciotta livia Biomedica Cardiovascular and Respiratory Sciences Cardiovascular Sciences Small Business SECS RF‐2013‐ 02356280 Influence of metalloestrogens on risk of developing different breast cancer subtypes: an Italian cohort study ISTITUTO TUMORI MILANO Sieri Sabina Clinico‐ Population Sciences and assistenzial Epidemiology e Epidemiology of Cancer ‐ EPIC RF‐2013‐ 02356292 Multiple and inducible gene therapy for improving peripheral nerve regeneration. Piemonte Tos Pierluigi Biomedica Bioengineering Sciences and Technologies Gene and Drug Delivery Systems ‐ GDD RF‐2013‐ 02356294 Paediatric Bipolar Disorder with comorbid Attention Deficit / Hyperactivity: new peripheral putative biomarkers and preclinical assessment of pharmaco‐ therapy. Istituto Superiore di Sanita' Adriani Walter Biomedica Brain Disorders and Clinical Neuroscience Pathophysiological Basis of Mental Disorders and Addictions ‐ PMDA RF‐2013‐ 02356297 Occupational skin diseases: preventive measures and individual susceptibility Friuli‐Venezia Giulia Francesca Clinico‐ Musculoskeletal, Oral and assistenzial Skin Sciences e Marimpietri Rui Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Arthritis, Connective Tissue and Skin ‐ ACTS Pagina 232 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02356304 Killing replicating and nonreplicating bacilli to fight tuberculosis RF‐2013‐ 02356308 Epidemiological methodology of Salmonella spp in Puglia Puglia isolated from human and non‐human sources: isolation, identification, drug resistance and cluster analysis. RF‐2013‐ 02356315 A genome‐based and functional approach to improve the Piemonte diagnosis and define the molecular bases of syndromic and non‐syndromic intellectual disability. RF‐2013‐ 02356316 Genetic abnormalities in C3 glomerulopathies and in immune‐complex‐associated membranoproliferative glomerulonephritis RF‐2013‐ 02356317 New strategies for therapeutic and clinical care in human NEUROMED glioblastoma RF‐2013‐ 02356327 Cyclophosphamide as sole graft‐vs.‐host disease prophylaxis in allogeneic hematopoietic stem cell transplantation from HLA‐identical donors: effects on transplant related toxicity and graft‐vs.‐leukemia tumor/effect. RF‐2013‐ 02356334 Development of diagnostic and prognostic epigenetic NEUROMED tools for facioscapulohumeral muscular dystrophy (FSHD) RF‐2013‐ 02356343 Effects of continuous and intermittent hypoxia on Oncogenesis Puglia RF‐2013‐ 02356345 Dynamics of peripheral blood molecular signatures and circulating tumor cells to predict recurrence in high risk tumor resected melanoma patients Istituto Superiore di Sanita' Moschella Piemonte Classificazione 1 Liv. Classificazione 2° liv. Lanfranco Biomedica Infectious Diseases and Microbiology Small Business: Non‐ HIV Anti‐Infective Therapeutics ‐ SBN De Vito Danila Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS Brusco Alfredo Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD Noris Marina Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD Arcella Antonietta Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT BRUNO BENEDETTO Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC Della Ragione Floriana Biomedica Skeletal Muscle Biology and Exercise Physiology ‐ SMEP lacedonia donato Clinico‐ Interdisciplinary Molecular assistenzial Sciences and Training e Fellowship: Oncological Sciences ‐ F09 Federica Biomedica Cancer Biomarkers ‐ CBSS Istituto Superiore di Sanita' Fattorini MARIO NEGRI AREA P.I. Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Musculoskeletal, Oral and Skin Sciences Oncology 2 ‐ Translational Clinical Pagina 233 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02356347 Exposure to chemicals, pesticides and substances of abuse in pregnant women: evaluation of DNA damage and oxidative stress parameters in peripheral lymphocytes as biomarkers of reproductive risk Toscana RF‐2013‐ 02356349 Impact of prenatal exposure to new anti‐HCV agents on maternal and neonatal outcomes. RF‐2013‐ 02356360 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. EMANUELA Biomedica Istituto Superiore di Sanita' Floridia Marco Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Pregnancy and Neonatology ‐ PN Food Safety and Endocrine Disruptors: a) levels of Bisphenols into canned food and beverages produced in Italy and b) direct risk assessment for humans IZSME Gallo Pasquale Biomedica Food Safety ‐ FOSA RF‐2013‐ 02356361 Identification of ncRNAs as biomarkers for early detection of aggressive prostate cancer in plasma and tissues Piemonte zitella andrea Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02356366 N‐formyl peptide receptors (FPRs) expression in Systemic Campania Sclerosis subsets ‐ a marker of fibrosis or vascular dysfunction? de Paulis Amato Biomedica Innate Immunity And Inflammation ‐ III RF‐2013‐ 02356367 Metabolic Risk Profiling for Prostate Cancer Management Emilia‐Romagna Marchesini Reggiani Giulio Clinico‐ Population Sciences and assistenzial Epidemiology e Epidemiology of Cancer ‐ EPIC RF‐2013‐ 02356369 Assessment and remediation of cognitive functions and communicative abilities in traumatic brain injured patients. Behavioral improvement and cerebral changes in functional brain connectivity. Piemonte Carrara Giovanna Clinico‐ Biobehavioral and assistenzial Behavioral Processes e Language and Communication ‐ LCOM RF‐2013‐ 02356371 MRI neurography assessment of nerve regeneration due to treatment in injury , compressive and degenerative peripheral neuropathies. SANTA LUCIA VADALA' RITA Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroplasticity and Neurotransmitters ‐ CNNT RF‐2013‐ 02356372 A novel TRAIL‐based therapeutic by Mesenchymal cells TARgeting PAncreatic Cancer (TARPAC) Emilia‐Romagna Dominici Massimo Biomedica Tumor Microenvironment ‐ TME MASINI Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Risk, Prevention and Health Behavior Veterinary Immunology Oncology 1 ‐ Basic Translational SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan ‐ TPM1 Pagina 234 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02356385 Assessment of horizontal transfer of toxin and antibiotic resistance genes between pathogenic clostridia and probiotic bacteria. RF‐2013‐ 02356387 SAN RAFFAELE MILANO Deciphering the role of the mTOR pathway in the regulation of ASCL1‐induced invasiveness of glioblastoma cancer stem cells RF‐2013‐ 02356393 Next generation sequencing techniques to identify new forms of inherited thrombocytopenias and to change the diagnostic approach to patients with low platelet count RF‐2013‐ 02356394 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Giovanna Biomedica Infectious Diseases and Microbiology Topics in Bacterial Pathogenesis Special Emphasis Panel ‐ ZRDM Galli Rossella Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP NORIS PATRIZIA Clinico‐ Vascular and Hematology assistenzial e Hemostasis and Thrombosis ‐ HT New ASIC channel inhibitors for the treatment of chronic SAN RAFFAELE MILANO neuro‐inflammation Muzio Luca Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT RF‐2013‐ 02356395 Veneto Identification of genetic profiles associated with IgE variability in bakers exposed to occupational allergens by exome sequencing Olivieri Mario Biomedica Population Sciences and Epidemiology Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions ‐ IRAP RF‐2013‐ 02356396 Computer‐based rehabilitation of communicative disorders in acquired cerebral injury MAUGERI pistarini caterina Biomedica Healthcare Delivery and Methodologies Biomedical Computing and Health Informatics ‐ BCHI RF‐2013‐ 02356402 Analysis of human epididymis protein 4 in epithelial ovarian cancer: biological role and predictive significance Lombardia Tognon Germana Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02356411 Investigating epigenetic patterns induced by different diets and food for cancer‐preventive health enhancement I.E.O. LUZI LUCILLA Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD RF‐2013‐ 02356413 Targeted glomerular delivery of Brain Derived Neurotrophic Factor (BDNF) to repair podocyte cytoskeleton in proteinuric diseases. MAGGIORE Cellesi Francesco Biomedica Bioengineering Sciences and Technologies Nanotechnology ‐ NANO Istituto Superiore di Sanita' Franciosa SAN MATTEO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 235 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02356415 Physiotherapy and Osteoporosis: Identification of clinical Sicilia and biological markers for the optimisation of the individualized approach to rehabilitation Programs RF‐2013‐ 02356418 Role of diaphragmatic ultrasonography in the diagnosis and prognosis in respiratory evaluation in patient with amyotrophic lateral sclerosis (Eco.Di.SLA) RF‐2013‐ 02356421 AREA P.I. Classificazione 1 Liv. Lio Domenico Biomedica Emilia‐Romagna Fantini Riccardo Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR Type 4 Phosphodiesterases as novel targets to reduce cardiovascular comorbidities in COPD. Abruzzo Davì Giovanni Biomedica Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR RF‐2013‐ 02356422 CYTOKINES, GROWTH FACTORS AND HEART RATE VARIABILY MARKERS OF JOB STRAIN. A PROPOSPECTIVE COLLABORATIVE STUDY. Friuli‐Venezia Giulia Larese Filon Francesca Clinico‐ Risk, Prevention and assistenzial Health Behavior e Psychosocial Development, Risk, and Prevention ‐ PDRP RF‐2013‐ 02356423 Microbiome assessment in the myocardial tissue of patients with dilated cardiomyopathy andmyocarditis negative to the known cardiotropic viruses. SPALLANZANI Frustaci Andrea Biomedica Clinical Research and Field Studies of Infectious Diseases ‐ CRFS RF‐2013‐ 02356424 Evidence of a therapeutic role of NGF in multiple sclerosis: clinical and experimental studies. BIETTI Centofanti Marco Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroimmunology and Brain Tumors ‐ CNBT RF‐2013‐ 02356428 TAVI versus Sutureless for the treatment of severe aortic stenosis in high risk patients: a multicenter prospectic randomized study Emilia‐Romagna Gherli Tiziano Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma ‐ SAT RF‐2013‐ 02356430 Role of lipid signaling in Alzheimer¿s disease: identification and modulation of survival molecular pathways to counteract neurodegeneration. SAN RAFFAELE PISANA CIRIOLO MARIA ROSA Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Musculoskeletal, Oral and Skin Sciences Classificazione 2° liv. Cardiovascular and Respiratory Sciences Infectious Diseases and Microbiology Skeletal Biology Development and Disease ‐ SBDD Pagina 236 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE Classificazione 1 Liv. Classificazione 2° liv. RF‐2013‐ 02356433 Whole‐exome sequencing and induced Pluripotent Stem Cells technology: new tools to explore the genetic causes of intellectual disability CASA SOLLIEVO SOFFERENZA Bernardini Laura Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD RF‐2013‐ 02356435 Explore, Identify and Validate predictive/prognostic biomarkers for Diabetic Macular Edema: an onsite analysis. BIETTI Micera Alessandra Biomedica Cell Biology Biology and Diseases of the Posterior Eye ‐ BDPE RF‐2013‐ 02356437 LONGITUDINAL MRI STUDY IN PRE‐MCI SUBJECT: IMAGING BIOMARKERS OF EARLY PRODROMAL NEURODEGENERATIVE CHANGES SANTA LUCIA GIUGNI ELISABETTA Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02356440 Clinical and genetic characterization of a relevant cohort Toscana of Myasthenia gravis patients to predict clinical pathways and development of teleconsultant activities for remote monitoring of the patient. Migliore Lucia Clinico‐ Healthcare Delivery and assistenzial Methodologies e Biostatistical Methods and Research Design ‐ BMRD RF‐2013‐ 02356442 AUTOPHAGY IN PLASMA CELL ONTOGENESIS AND MALIGNANCY SAN RAFFAELE MILANO Cenci Simone Biomedica Immunology Cellular and Molecular Immunology B ‐ CMIB RF‐2013‐ 02356444 Neuroplasticity and Alzheimer's disease: integrated approach to identify biological and neurophysiological markers. FATEBENEFRATELLI Miniussi Carlo Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02356448 Subthalamic nucleus deep brain stimulation in Tourette syndrome CARLO BESTA Albanese Alberto Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02356454 IN VITRO METABOLIC PROFILING OF EPITHELIAL OVARIAN CANCER CELLS AS A MARKER OF RESPONSE TO PLATINUM CHEMOTHERAPY I. O. V. Amadori Alberto Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Pagina 237 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02356457 A multidisciplinary approach that combines evolutionary MEDEA analysis, protein modelling, clinical and epidemiological genetics to clarify the pathogenic mechanisms underlying viral/bacterial encephalitis. RF‐2013‐ 02356459 Are genetic, inflammatory and metabolomic markers of coronary heart disease related to kidney function decline in patients with type 2 diabetes? RF‐2013‐ 02356460 Impact on clinical care of the reorganization of test for antiphospholipid antibodies in laboratory analysis. RF‐2013‐ 02356462 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Cagliani Rachele Biomedica Genes, Genomes and Genetics CASA SOLLIEVO SOFFERENZA Menzaghi Claudia Clinico‐ Population Sciences and assistenzial Epidemiology e Kidney, Nutrition, Obesity and Diabetes ‐ KNOD Friuli‐Venezia Giulia fabris martina Clinico‐ Vascular and Hematology assistenzial e Hemostasis and Thrombosis ‐ HT Lombardia Preclinical development of anticoagulant compounds, selective inhibitors of thrombin and activated Factor X, as potential antitumor strategies in pancreatic cancer Falanga Anna Biomedica Tumor Cell Biology ‐ TCB RF‐2013‐ 02356466 Biological profile of monocyte‐derived macrophages and MONZINO its correlation with plaque morphology in ischemic heart disease Marenzi Giancarlo Silvio Clinico‐ RF‐2013‐ 02356479 Cellular and animal models of Panthothenate Kinase Associated Neurodegeneration (PKAN): from pathogenesis to drug screening. Lombardia FINAZZI RF‐2013‐ 02356481 Role of CD8+CD57+ T cells in response to Epstein‐Barr Virus and in Multiple Sclerosis SANTA LUCIA RF‐2013‐ 02356483 RF‐2013‐ 02356485 Oncology 1 ‐ Basic Translational Genetic Variation and Evolution ‐ GVE Cardiovascular and assistenzial Respiratory Sciences e Myocardial Ischemia and Metabolism ‐ MIM DARIO Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND Cencioni Maria Teresa Biomedica Immunology Immunity and Host Defense ‐ IHD The molecular basis of the interplay between leukotriene Lombardia and purinergic systems: new therapies in vascular inflammation Cattaneo Marco Natale Biomedica Cardiovascular and Respiratory Sciences Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR IN VIVO EVALUATION OF THE ROLE OF METFORMIN Lazio IN THE TREATMENT OF ENDOMETRIAL CANCER Angioli Roberto Biomedica Oncology 2 ‐ Translational Clinical Drug Discovery and Molecular Pharmacology ‐ DMP Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 238 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02356487 Cord blood expanded endothelial progenitors in patients Lazio with untreatable critical limb ischemia: manufacture and validation of a definite allogenic cell therapy product, safety assessment in patients candidate to amputation and study of the immunological RF‐2013‐ 02356489 Towards a personalized treatment of metastatic melanoma: study on intrinsic resistance to MAPK inhibitors. RF‐2013‐ 02356490 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Teofili Luciana Clinico‐ Vascular and Hematology assistenzial e Vascular Biology Special Emphasis Panel ‐ SEVB I. O. V. Rossi Carlo Riccardo Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Basic Mechanisms of Cancer Therapeutics ‐ BMCT Prediction of Cardiovascular Risk by Cardiopulmonary Exercise Testing: the EURO(pean) EX(ercise) Population‐ Based Study SAN DONATO guazzi marco Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS RF‐2013‐ 02356491 Continuous care model for elderly patients who need hospital resources in the last years of their life Lombardia scandiani luciana Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02356493 Evaluation of the immune response against Mycobacterium avium subsp. paratuberculosis (MAP) in humans and animals IZSUM Mazzone Piera Biomedica Immunity and Host Defense ‐ IHD RF‐2013‐ 02356494 Mild cognitive impairment and progression to Alzheimer's disease: association with herpes viruses infections. Emilia‐Romagna Gabrielli Liliana Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02356495 identification of mutated sheep prion protein resistent to IZSUM conversion into PrPSc Biagetti Massimo Biomedica Veterinary Animal Health ‐ ANHE RF‐2013‐ 02356496 Searching for new biomarkers in Autism Spectrum Disorders (ASDs) by DNA methylation profile and gene expression analysis of ASD discordant sibpairs Veneto Dall Bernardina Bernardo Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD RF‐2013‐ 02356501 Health and healthcare for elderly immigrants and minorities in an italian area with high immigration and ageing index: an integrated approach based on cultural competency and ethnogeriatric personalized care Emilia‐Romagna colantoni alessandra Clinico‐ Healthcare Delivery and assistenzial Methodologies e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Immunology Health Services Organization and Delivery ‐ HSOD Pagina 239 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02356504 Neuron targeting of nanoparticle‐conjugated siRNAs to correct the mitochondrial phenotype in neurological diseases Campania NITSCH LUCIO Biomedica Bioengineering Sciences and Technologies Gene and Drug Delivery Systems ‐ GDD RF‐2013‐ 02356511 Epigenetic signature of cardiomyocytes in modulating in the immune response of heart failure: a new therapeutic target HUMANITAS PAPAIT ROBERTO Biomedica Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF RF‐2013‐ 02356512 The purinergic P2X7 receptor on human cardiac fibroblast: a new therapeutic target for adverse cardiac remodelling in chronic heart failure? Toscana Laghi Pasini Franco Biomedica Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF RF‐2013‐ 02356516 Veneto A randomized controlled trial of a psychosocial INTERvention on relapse prevention in patients in the first 5 years from psychosis onset and their relatives in the VENEto region: feasibility, effectiveness, predictors of outcome and impact on Mental Healt Ruggeri Mirella Clinico‐ Biobehavioral and assistenzial Behavioral Processes e Adult Psychopathology and Disorders of Aging ‐ APDA RF‐2013‐ 02356518 Novel multi‐analyte point‐of‐care testing device for rapid Toscana diagnosis and management of sepsisand severe infection. Esin Semih Biomedica Interdisciplinary Molecular Sciences and Training Small Business: Devices and Detection Systems ‐ SBDS RF‐2013‐ 02356520 Modulation of microRNA profiles in models of celiac disease by toxic and immunomodulatory gliadin peptides : potential therapeutic implication for celiac disease Istituto Superiore di Sanita' VINCENTINI OLIMPIA Biomedica Digestive, Kidney and Urological Systems Gastrointestinal Mucosal Pathobiology ‐ GMPB RF‐2013‐ 02356528 Role of altered presynaptic proteins‐mediated synaptic plasticity in cognitive decline in the aging brain I.N.R.C.A. Conti Fiorenzo Biomedica Molecular, Cellular, and Developmental Neuroscience Synapses, Cytoskeleton and Trafficking ‐ SYN RF‐2013‐ 02356529 New cell and receptor suspects in autoimmune type 1 diabetes SAN RAFFAELE MILANO Maugeri Norma Biomedica Immunology Innate Immunity And Inflammation ‐ III Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 240 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02356533 NON‐CONVENTIONAL PROGNOSTIC MARKERS AND THERAPEUTICAL TARGETS IN DEVELOPMENT AND PROGRESSION OF BLADDER CANCER RF‐2013‐ 02356536 Short‐term starvation as a strategy to improve the efficacy GASLINI of tyrosine kinase inhibitors in cancer RF‐2013‐ 02356544 Role of the Plasmodium Subtilisin‐like protease Sub1 in gamete egress from the host erythrocyte. RF‐2013‐ 02356545 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Alfano Massimo Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS Raffaghello Lizzia Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB Istituto Superiore di Sanita' pace tomasino Biomedica Infectious Diseases and Microbiology Pathogenic Eukaryotes ‐ PTHE MITOCHONDRIAL CALCIUM HOMEOSTASIS AND NEURODEGENERATION IN RODENT AND PRIMATE MODELS OF PARKINSON AND HUNGTINGTON DISEASE Veneto d'avella domenico Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02356551 D.Ha.R.P.: Dietary Habits, Nuclear Receptors, and Pancreatic Cancer Toscana Galli Andrea Biomedica Oncology 1 ‐ Basic Translational Tumor Progression and Metastasis ‐ TPM2 RF‐2013‐ 02356552 Shedding new light on well‐differentiated follicular derived thyroid carcinoma: microfluidic thyroid‐on‐chip device as a tool for the identification of novel diagnostic/prognostic biomarkers toward a patient‐ specific treatment Lazio CRESCENZI Anna Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB RF‐2013‐ 02356559 Novel computer based motor rehabilitation and brain connectivity in Huntington's Disease SANTA LUCIA Di Paola Margherita Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02356560 Search for Markers of Damage in Hematopoietic Cells in patients cured after childhood cancer GASLINI Frassoni Francesco Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP RF‐2013‐ 02356562 Novel biomarkers and therapeutic targets for the human malignant pleural mesothelioma. Emilia‐Romagna Tognon Mauro Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB SAN RAFFAELE MILANO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 241 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02356564 A Twin Study on the Relation between Psychological and Istituto Superiore di Sanita' Fagnani Immunological Functioning RF‐2013‐ 02356570 Cross‐disease Expression of Somatoform Phenotypes‐ Epidemiology and Pathophysiology Abruzzo RF‐2013‐ 02356571 A multidisciplinary study for the discovery of new clinical, metabolomic and proteomic markers for the prediction and detection of gestational diabetes RF‐2013‐ 02356572 Novel nanotechnology‐based strategies for diagnostic, therapeutic and and clinical care in lymphoma. RF‐2013‐ 02356575 Istituto Superiore di Sanita' Giammarioli Pyrimethamine derivatives: a new class of "low cost" antifolate drugs for treatment of metastatic melanoma. A preclinical study. RF‐2013‐ 02356583 Immunoprofiling as predictive biomarker to select patients candidate to be treated with agents modulating immune check points ISTITUTO TUMORI MILANO RF‐2013‐ 02356588 Can multi parametric Magnetic Resonance Imaging (mp‐ MRI) reduce overdiagnosis and overtreatment in screening for Prostate Cancer ? An one‐arm pilot study in the Florence area. RF‐2013‐ 02356589 Mediterranean plants for Human and a Sustainable Livestock Health care AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Corrado Biomedica Biobehavioral and Behavioral Processes Biobehavioral Mechanisms of Emotion, Stress and Health ‐ MESH Onofrj Marco Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN Veneto Lapolla Annunziata Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Pregnancy and Neonatology ‐ PN Toscana D'Elios Mario Milco Clinico‐ Interdisciplinary Molecular assistenzial Sciences and Training e Small Business: Biomaterials, Delivery Systems, and Nanotechnology ‐ SBBD Anna Maria Biomedica Cancer Molecular Pathobiology ‐ CAMP DE BRAUD FILIPPO Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS Toscana Zappa Marco Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS IZSSI Reale Stefano Biomedica Animal Health ‐ ANHE Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Oncology 1 ‐ Basic Translational Veterinary Pagina 242 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02356590 The role of periostin in the pathogenesis and progression Calabria of endometriosis and ovarian cancer endometriosis related. ZULLO FULVIO Clinico‐ Oncology 1 ‐ Basic assistenzial Translational e Molecular Oncogenesis ‐ MONC RF‐2013‐ 02356591 Assessing the in vivo efficacy of peptide therapeutics towards the progression of Amyotrophic Lateral Sclerosis MAUGERI Rossi Daniela Maria Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN RF‐2013‐ 02356594 Cognitive impairment in Neurodevelopment Disorders and in early onset Multiple Sclerosis: searching for distinctive/common pathogenic insights and predictive biomarkers of clinical course Puglia Margari Lucia Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD RF‐2013‐ 02356595 Inhibition of JNK‐PSD95 interaction: a novel strategy to prevent Alzheimer's disease MARIO NEGRI Borsello Tiziana Biomedica Integrative, Functional, and Cognitive Neuroscience Neurobiology of Learning and Memory ‐ LAM RF‐2013‐ 02356604 Epilepsy and sudden death: Identification and prevention Lazio of relatives using genetic diagnosis Oliva Antonio Biomedica Brain Disorders and Clinical Neuroscience Acute Neural Injury and Epilepsy ‐ ANIE RF‐2013‐ 02356606 Effect of surgical or conservative approach in patients with adrenal incidentalomas on cardiovascular, metabolic, neuropsychological and bone manifestations: respective roles of cortisol secretion and glucocorticoid sensitivity. Chiodini Iacopo Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Integrative and Clinical Endocrinology and Reproduction ‐ ICER RF‐2013‐ 02356614 Osteopenia and osteoporosis in HIV infected patients: the Emilia‐Romagna role of the virus and antiretroviral drugs. Re Maria Carla Biomedica AIDS and Related Research AIDS Immunology and Pathogenesis ‐ AIP RF‐2013‐ 02356618 Detection of DNA mutations in urine of patients with prostate cancer for the identification of early prognostic biomarkers Emilia‐Romagna Dell' Atti Lucio Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC RF‐2013‐ 02356619 Assessment of botulinum toxin effect on skeletal muscle CARLO BESTA Zanotti Simona Biomedica Musculoskeletal, Oral and Skin Sciences Skeletal Muscle Biology and Exercise Physiology ‐ SMEP MAGGIORE Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 243 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02356624 RIZZOLI Treatment of joint degeneration: a new strategy for a new etiopathology target. A comparative study on cell free scaffold vs bone marrow concentrate for subchondral bone lesions. Marcacci Maurilio Clinico‐ Musculoskeletal, Oral and assistenzial Skin Sciences e Arthritis, Connective Tissue and Skin ‐ ACTS RF‐2013‐ 02356628 Screening for silent atrial fibrillation in the elderly: potential for stroke prevention Umbria Becattini Cecilia Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02356635 Myeloid cell and adipocyte interaction in human bone marrow of frail elders: identification of biomolecular markers and therapeutic targets of immune senescence Veneto BRONTE VINCENZO Biomedica Cellular Mechanisms in Aging and Development ‐ CMAD RF‐2013‐ 02356638 Duchenne Muscular Dystrophy: a study of the natural history of respiratory muscles assessed by new noninvasive diagnostic techniques MEDEA D'Angelo Maria Grazia Clinico‐ Musculoskeletal, Oral and assistenzial Skin Sciences e Musculoskeletal Rehabilitation Sciences ‐ MRS RF‐2013‐ 02356641 Impact of asbestos‐mediated inflammation in mesothelioma genesis and progression. Implication for early diagnosis, prognosis and therapy HUMANITAS SICA ANTONIO Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME RF‐2013‐ 02356642 New Doxorubicin hepatic delivery strategy by ultrasound Veneto microbubbles and sonoporation, and effects of heme oxygenase‐1 induction and inhibition, in the treatment of hepatocellular carcinoma (HCC) in rats: evaluation of antineoplastic effects, prevention o Sacerdoti David Biomedica Oncology 2 ‐ Translational Clinical Developmental Therapeutics ‐ DT RF‐2013‐ 02356644 Individual prediction of urinary toxicity after radiotherapy of prostate cancer: incorporating clinical, dosimetric and genomic/molecular parameters into predictive models SAN RAFFAELE MILANO FIORINO CLAUDIO Biomedica Oncology 2 ‐ Translational Clinical Radiation Therapeutics and Biology ‐ RTB RF‐2013‐ 02356645 Effects of Neuropeptide Y on the central nervous system neurons of rat models of Alzheimer Disease SANTA LUCIA Angelucci Francesco Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroplasticity and Neurotransmitters ‐ CNNT Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Biology of Development and Aging Pagina 244 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02356646 Impact of gender and of reproductive status on liver damage and cardiovascular dysfunction in patients with Nonalcoholic Fatty Liver Disease Piemonte Vanni Ester Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Hepatobiliary Pathophysiology ‐ HBPP RF‐2013‐ 02356650 HEALTH OUTCOME AND MOLECULAR BASIS OF PRIMARY HYPOBETALIPOPROTEINEMIAS Emilia‐Romagna Lonardo Amedeo Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences (EMNR) Integrated Review Group Fellowship Panel ‐ F06 RF‐2013‐ 02356651 Cardiac remodelling in obese patients after different bariatric procedures: novel tools in Cardiac Magnetic Resonance and andselection of a novel cluster of cardio‐ metabolic biomarkers. Lazio Carbone Iacopo Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Medical Imaging ‐ MEDI RF‐2013‐ 02356654 FIBRIN CLOT PROPERTIES, FIBRINOGEN OXIDATION Toscana AND OXIDATIVE STRESS IN ISCHEMIC STROKE: AN `IN VIVO' STUDY IN THE ACUTE PHASE AND AFTER INTRAVENOUS AND INTRA‐ARTERIAL Marcucci Rossella Biomedica Hemostasis and Thrombosis ‐ HT RF‐2013‐ 02356663 Identification of independent biomarkers predicting aortic dissections in patients with Marfan syndrome. AUXOLOGICO Salvi Paolo Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS RF‐2013‐ 02356665 DEVELOPMENT, VALIDATION AND CLINICAL APPLICATION OF NEXT GENERATION SEQUENCING MULTIGENIC PIPELINES FOR DETECTION AND DYNAMIC CHARACTERIZATION TOWARD PERSONALIZATION OF CANCER PREVENTION AND TREATMENT. Abruzzo Ricevuto Enrico Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02356671 Study of the role played by S100B and RAGE in Amyotrophic Lateral Sclerosis‐induced astrocytosis and motoneuron death Lazio Michetti Fabrizio Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Endocrinology, Metabolism, Nutrition and Reproductive Sciences Vascular and Hematology Pagina 245 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02356680 Combined targeting of cancer cells and tumor‐supporting SAN RAFFAELE MILANO microenvironment by Natural Killer T lymphocytes engineered with tumor‐specific TCRs Dellabona Paolo Biomedica RF‐2013‐ 02356687 The possible influence of fat‐soluble vitamins on cognition and brain structural integrity in patients with Secondary Progressive Multiple Sclerosis: a longitudinal study. Nocentini Ugo Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02356689 A RANDOMIZED OPEN‐LABEL STUDY COMPARING Puglia EVEROLIMUS AT DIFFERENT DOSES WITH STANDARD THERAPY IN THE ABILITY TO DELAY THE PROGRESSION OF DIABETIC NEPHROPATHY DI PAOLO SALVATORE Biomedica Pathobiology of Kidney Disease ‐ PBKD RF‐2013‐ 02356696 Impact of diet and physical activity on quality of life and outcome of patients operated for lung cancer I.E.O. Gnagnarella Patrizia Clinico‐ Population Sciences and assistenzial Epidemiology e Epidemiology of Cancer ‐ EPIC RF‐2013‐ 02356697 CirculAting VEsicles: The hidden sites of neurodegeneration (CAVE) FATEBENEFRATELLI Ghidoni Roberta Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02356700 Residual evolution of HIV env V3 sequence in virologically suppressed patients undergoing Maraviroc‐ including antiretroviral therapy. Marche Bagnarelli Patrizia Biomedica AIDS and Related Research AIDS Immunology and Pathogenesis ‐ AIP RF‐2013‐ 02356704 New insights in the diagnosis and management of patients with mitochondrial disorders in the view a new therapeutic era: natural history, biomarkers, outcome measures and quality of life Sicilia Musumeci Olimpia Clinico‐ Musculoskeletal, Oral and assistenzial Skin Sciences e Skeletal Muscle Biology and Exercise Physiology ‐ SMEP RF‐2013‐ 02356707 Improving aphasia rehabilitation: New tools for administering and directing therapy SANTA LUCIA Guariglia Cecilia Clinico‐ Integrative, Functional, assistenzial and Cognitive Neuroscience e Cognitive Neuroscience ‐ COG SANTA LUCIA Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Immunology Digestive, Kidney and Urological Systems Transplantation, Tolerance and Tumor Immunology ‐ TTT Pagina 246 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02356709 Analysis of the interplay between oxidative stress and familiarity for atrial fibrillation RF‐2013‐ 02356712 IMPROVING QUALITY AND CARE OPTIONS FOR THE Toscana END‐OF‐LIFE IN ADVANCED HEART FAILURE. RF‐2013‐ 02356715 Antibodies long term persistence and memory cells role after different pneumococcal vaccine strategies in HIV adults RF‐2013‐ 02356718 7‐Transmembrane Receptors/Trasforming Growth Factor Campania Beta Receptors Biased‐Crosstalk: A Novel Concept for Nanotherapy of Cardiac Fibrosis in Heart Failure RF‐2013‐ 02356719 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. violi francesco Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF EMDIN MICHELE Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD Montagnani Francesca Clinico‐ Immunology assistenzial e Immunity and Host Defense ‐ IHD Esposito Giovanni Biomedica Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF Natural eye drops from allogeneic umbilical cord blood plasma Istituto Superiore di Sanita' Grazzini Giuliano Biomedica Healthcare Delivery and Methodologies Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02356720 Antidepressant activity of fingolimod in experimental animal models and patients with multiple sclerosis NEUROMED Bruno Valeria Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT RF‐2013‐ 02356722 Embryonal tumors of the brain: analysis of epigenetic networks NEUROMED Gulino Alberto Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP RF‐2013‐ 02356727 Active surveillance or radical treatment in patients with Piemonte newly diagnosed low risk prostate cancer: a population‐ based comparative effectiveness study in the Oncological Network of Piedmont and Valle d'Aosta Ciccone Giovannino Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02356730 Understanding Human Papillomavirus (HPV) Natural Infection in Head and Neck Cancer to Develop New Preventive, Diagnostic, and Treatment Strategies Piemonte SUCCO GIOVANNI Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS Lazio Toscana Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 247 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02356732 EFFECTIVENESS OF 3D‐ULTRASOUND‐GUIDED SURGERY IN IMPROVING PATIENTS CLINICAL OUTCOME AND SURVIVAL IN BRAIN TUMOURS SAN RAFFAELE MILANO Mortini Pietro Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroimmunology and Brain Tumors ‐ CNBT RF‐2013‐ 02356746 Physically driven nanocarriers for the controlled delivery of apomorphine and levodopa in Parkinson's disease AUXOLOGICO PRIANO LORENZO Biomedica Bioengineering Sciences and Technologies Gene and Drug Delivery Systems ‐ GDD RF‐2013‐ 02356754 NOVEL STRATEGIES FOR MOLECULAR DIAGNOSIS AND RISK STRATIFICATION OF PATIENTS WITH CHRONIC HEART FAILURE. Campania Piscione Federico Biomedica Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF RF‐2013‐ 02356755 Counselling and Service Delivery program to increase the Emilia‐Romagna adherence to Mediterranean Diet and to reduce the risk of cardiovascular disease STORCHI MARCO Clinico‐ Risk, Prevention and assistenzial Health Behavior e Psychosocial Risk and Disease Prevention ‐ PRDP RF‐2013‐ 02356758 Studies on the role of the neuron‐astrocyte‐microglia triad in the pathogenesis of cerebral ischemia Toscana Pellegrini Giampietro Domenico Edoardo Biomedica Brain Injury and Neurovascular Pathologies ‐ BINP RF‐2013‐ 02356759 Assessing the Risk of Falls in the Elderly of Long‐term care institutions through Instrumental Sit‐to‐stand test (ARFELIS) DON GNOCCHI Castiglioni Paolo Clinico‐ Risk, Prevention and assistenzial Health Behavior e SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan ‐ TPM1 RF‐2013‐ 02356762 The genetics of sudden cardiac death in athletes and implication for risk prevention Veneto THIENE GAETANO Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR RF‐2013‐ 02356772 Development of new biomarkers to stratify the PML risk in multiple sclerosis patients during Natalizumab therapy: study of the potential correlation between presence of human Polyomavirus JC DNA in blood/urine samples and cytokine‐chemokine profiling in p Lazio Pietropaolo Valeria Antonietta Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Brain Disorders and Clinical Neuroscience Classificazione 2° liv. Pagina 248 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02356780 Immune response to human cytomegalovirus in the immunocompetent and the immunocompromised host: new approaches and their clinical impact RF‐2013‐ 02356781 Influence of microbioma on biological activity of CXCR4, SAN RAFFAELE MILANO CCR5 and CCR6 during a mucosal chronic inflammation. RF‐2013‐ 02356785 EZH2 epigenetic regulation of the HIPK2/p53/Pin1 circuitry in chemoresistant melanoma: identification of molecular switches as new therapeutic targets RF‐2013‐ 02356787 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. spinillo arsenio Biomedica Infectious Diseases and Microbiology Virology A and B Study Sections ‐ VIRA and VIRB Pastori Claudia Biomedica Immunology Hypersensitivity, Autoimmune, and Immune ISTITUTO DERMOPATICO DELL'IMMACOLATA ciarapica roberta Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP LEFT VENTRICULAR HYPERTROPHY IN AORTIC VALVE DISEASE AND HYPERTROPHIC CARDIOMYOPATHY: GENETIC BASIS, BIOPHYSICAL CORRELATES AND VIRAL THERAPY MODELS Toscana Olivotto Iacopo Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF RF‐2013‐ 02356790 EXOME SEQUENCING IN EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS (EGPA) PATIENTS Emilia‐Romagna VAGLIO AUGUSTO Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD RF‐2013‐ 02356791 Immigrants and sanitation: an accurate diagnosis to assess the spread of parasitic infections and the associated immune modulation Campania Galdiero Massimiliano Biomedica Infectious Diseases and Microbiology Infectious Diseases and Microbiology Fellowship ‐ F13 RF‐2013‐ 02356792 Identification and validation of genes that control cellular I.E.O. plasticity, as novel cancer therapeutic targets. Moroni Mariacristina Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC RF‐2013‐ 02356796 ROLE OF TUMOR MICROENVIRONMENT IN IMMUNE Toscana MODULATION Amedei Amedeo Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME RF‐2013‐ 02356797 Clinical relevance of constitutional non‐truncating C.R.O. AVIANO mutations in APC gene: an integrated analysis to define the association between variants of uncertain significance and genetic risk of colo‐rectal polyposis and cancer Viel Alessandra Biomedica Oncology 1 ‐ Basic Translational Cancer Genetics ‐ CG SAN MATTEO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 249 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02356802 Inhibition of Glycolysis by 2‐Deoxy‐D‐Glucose as a Therapeutic Strategy for Polycystic Kidney Disease SAN RAFFAELE MILANO magistroni riccardo Biomedica Digestive, Kidney and Urological Systems Cellular and Molecular Biology of the Kidney ‐ CMBK RF‐2013‐ 02356804 Mutated calreticulin as a novel diagnostic marker and therapeutic target in chronic myeloproliferative neoplasms Toscana Vannucchi Alessandro Maria Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII RF‐2013‐ 02356822 SANTA LUCIA Interplay between autophagy and S‐nitrosylation: implications in the genesis, proliferation and resistance of glioblastoma stem cells Cecconi Francesco Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB RF‐2013‐ 02356829 Improving standards of care in Young Women with Breast Cancer: a translational approach C.R.O. AVIANO Massarut Samuele Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02356838 Assessment of gastrointestinal comorbidities in Autism Spectrum Disorders (ASD) Campania bravaccio carmela Biomedica Digestive, Kidney and Urological Systems Clinical, Integrative and Molecular Gastroenterology ‐ CIMG RF‐2013‐ 02356843 Analysis of the role of oxysterols/LXRs in tumorigenesis SAN RAFFAELE MILANO Russo Vincenzo Biomedica Immunology Transplantation, Tolerance and Tumor Immunology ‐ TTT RF‐2013‐ 02356844 Cerebrospinal fluid microparticles as biomarkers of Primary Progressive Multiple Sclerosis: a case‐control study Sicilia Salemi Giuseppe Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT RF‐2013‐ 02356848 In vitro and in vivo studies of homocysteine‐induced neurodegeneration and potential protective/reparative effects of nutraceutical compounds Sicilia CACCAMO DANIELA Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND RF‐2013‐ 02356855 Role of ApoL1 in the Pathogenesis of HIV‐Associated Nephropathy HUMANITAS Mikulak Joanna Biomedica AIDS and Related Research NeuroAIDS and other End‐organ Diseases ‐ NAED Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 250 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02356863 Sardegna Role of ovarian cancer microenvironment and related inflammatory and metabolic changes in the pathogenesis of patient's symptoms. Translational research for the implementation of a mechanism‐based treatment approach. Macciò Antonio Biomedica Oncology 2 ‐ Translational Clinical Clinical Oncology ‐ CONC RF‐2013‐ 02356867 Identification of human genes involved in the pathogenesis of keratoconus Veneto Ponzin Diego Biomedica Brain Disorders and Clinical Neuroscience Anterior Eye Disease ‐ AED RF‐2013‐ 02356873 The impact of a moderate CAlorie and protein REstriction PROgram (CARE‐PRO) as an efficient and affordable therapy in patients with Barrett's Esophagus. I. O. V. Realdon Stefano Clinico‐ Risk, Prevention and assistenzial Health Behavior e SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan ‐ TPM1 RF‐2013‐ 02356874 ICAROS ‐ Indagine sui Cluster di Aumento del Rischio Oncologico in Salento Puglia PISCITELLI PRISCO Clinico‐ Population Sciences and assistenzial Epidemiology e Epidemiology of Cancer ‐ EPIC RF‐2013‐ 02356883 Validation of the predictive role of LH‐Receptor expression for endometrial cancer patients stratification. Toscana NOCI IVO Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02356884 Prokineticin 2 in autoimmune demyelinating disease of the central nervous system: a possible novel target for immune intervention CARLO BESTA Pedotti Rosetta Biomedica Immunology Hypersensitivity, Autoimmune, and Immune RF‐2013‐ 02356885 Macrophages and the development of fibrosis during nonalcoholic fatty liver disease: role of interaction between iron metabolism and hypoxia‐inducible factor‐ 2alpha Toscana Marra Fabio Biomedica Digestive, Kidney and Urological Systems Hepatobiliary Pathophysiology ‐ HBPP RF‐2013‐ 02356894 New health care model for integrated multidisciplinary management and surgical treatment of complex pelvic floor dysfunctions: economic evaluation, careflow management and applicability to other clinical services Emilia‐Romagna Ascanelli Simona Clinico‐ Healthcare Delivery and assistenzial Methodologies e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Health Services Organization and Delivery ‐ HSOD Pagina 251 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02356895 Implementation of adherence work‐up by therapeutic drug monitoring (TDM) and integrated hemodynamic status assessment, for the management of resistant hypertension (RH) Piemonte VEGLIO FRANCO Clinico‐ Vascular and Hematology assistenzial e Hypertension and Microcirculation ‐ HM RF‐2013‐ 02356896 New diagnostic and therapeutic approaches in oncology based on the UN1/CD43 tumor antigen. Calabria Palmieri Camillo Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02356899 Hereditary Spastic Paraplegia: search for disease genes by SANTA LUCIA a network‐based approach ORLACCHIO ANTONIO Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02356910 Toscana IDENTIFICATION OF VASOACTIVE MEDIATORS CORRELATING WITH HEMODYNAMIC ALTERATIONS IN NEUROLOGICAL DISEASES: COMPARISON BETWEEN MULTIPLE SCLEROSIS AND OTHER NEUROLOGICAL DISEASES Monti Lucia Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02356912 Nucleotide Excision Repair and Accelerated Vascular Aging ISTITUTO DERMOPATICO DELL'IMMACOLATA Dellambra Elena Biomedica Biology of Development and Aging Cellular Mechanisms in Aging and Development ‐ CMAD RF‐2013‐ 02356913 Analysis of defects in the development of interneurons caused by dysregulation of Rac signaling relevant to neuropsychiatric disorders. SAN RAFFAELE MILANO de Curtis Ivanmatteo Biomedica Molecular, Cellular, and Developmental Neuroscience Neurodifferentiation, Plasticity, and Regeneration ‐ NDPR RF‐2013‐ 02356920 Perinatal Asphyxia, Neuroprotective Strategies and Brain Biomarkers Piemonte Gazzolo Diego Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD RF‐2013‐ 02356924 Role of the p21‐mediated DNA‐Damage Response in the immune‐surveillance of leukemia stem cells I.E.O. PELICCI PIER GIUSEPPE Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME RF‐2013‐ 02356932 Zoonotic potential and pathogenic role of the intestinal parasite Dientamoeba fragilis in pigs IZSUM Manuali Elisabetta Infectious Diseases and Microbiology Pathogenic Eukaryotes ‐ PTHE Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Biomedica Classificazione 1 Liv. Classificazione 2° liv. Pagina 252 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02356941 Kynurenine Pathway Metabolites and Suicide risk; a potential biomarker for suicide prevention Lazio Pompili Maurizio Clinico‐ Risk, Prevention and assistenzial Health Behavior e Psychosocial Development, Risk, and Prevention ‐ PDRP RF‐2013‐ 02356944 Blood brain barrier permeability in ALS from in vitro to in vivo AUXOLOGICO Bossolasco Patrizia Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN RF‐2013‐ 02356945 The functional role of Eukaryotic translation initiation factor 4h in Williams Beuren Syndrome: searching its direct downstream targets. SAN RAFFAELE MILANO Pannese Maria Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD RF‐2013‐ 02356946 Role of non‐coding RNAs in osteosarcoma stemness Toscana Brandi Maria Luisa Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD RF‐2013‐ 02356957 Host response to herpes simplex virus‐1 (HSV1) recurrent SAN RAFFAELE PISANA infections and Alzheimer's disease: looking for pathogenetic correlations and therapeutic vaccines. PALAMARA ANNA TERESA Biomedica Infectious Diseases and Microbiology Virology A and B Study Sections ‐ VIRA and VIRB RF‐2013‐ 02356960 Genomic and post‐genomic analysis of patients with rheumatoid arthritis treated with biological agents complicated by serious infections Lombardia Riva Agostino Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD RF‐2013‐ 02356962 Analysis of the impact of systemic autoimmune diseases on fertility, family planning, and on the family structure of patients. Toscana Mosca Marta Clinico‐ Population Sciences and assistenzial Epidemiology e Social Sciences and Population Studies ‐ SSPS RF‐2013‐ 02356966 Immunologic and complement activation mechanisms for antibody mediated rejection and mixed rejection in heart and kidney transplantation: the role of molecular biomarkers for diagnostic, prognostic and therapeutic strategies. Veneto Angelini Annalisa Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS RF‐2013‐ 02356970 BRAIN NETWORK DEGENERATION ASSESSED USING MULTIMODAL MRI TO EXPLAIN CLINICAL VARIABILITY IN ALZHEIMER'S DISEASE SAN RAFFAELE MILANO Magnani Giuseppe Clinico‐ Biobehavioral and assistenzial Behavioral Processes e Adult Psychopathology and Disorders of Aging ‐ APDA Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 253 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02356977 Epidemiology of stroke in the L'Aquila district Abruzzo Sacco Simona Clinico‐ Population Sciences and assistenzial Epidemiology e Neurological, Aging and Musculoskeletal Epidemiology ‐ NAME RF‐2013‐ 02356980 Targeting attention biases in depression: A longitudinal fMRI study SANTA LUCIA Fagioli Sabrina Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Pathophysiological Basis of Mental Disorders and Addictions ‐ PMDA RF‐2013‐ 02356992 Flow‐dynamic evaluation of endovascular aortic arch reconstruction by cardiovascular MRI with 4D technology and computational analysis Veneto Antonello Michele Clinico‐ Bioengineering Sciences assistenzial and Technologies e Instrumentation and Systems Development ‐ ISD RF‐2013‐ 02356995 Advanced in vitro efficacy predictivo tools for personalized design of immune checkpoint blockade immunotherapy Lazio Santini Daniele Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII RF‐2013‐ 02357004 Atrial Tissue Characteristics and Metabolic Dysregulation Emilia‐Romagna in Post‐Operative Atrial Fibrillation. A Substudy of the OPERA International Trial Corradi Domenico Biomedica Cardiovascular and Respiratory Sciences Clinical and Integrative Cardiovascular Sciences ‐ CICS RF‐2013‐ 02357006 Fosl2 as a p53 antagonist in cancer development and progression C.R.O. AVIANO Piccinin Sara Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC RF‐2013‐ 02357007 Dissecting host‐pathogen interplay: a systems biology approach to discover Plasmodium falciparum and Anopheles gambiae interactors Istituto Superiore di Sanita' Pizzi Elisabetta Biomedica Infectious Diseases and Microbiology Pathogenic Eukaryotes ‐ PTHE RF‐2013‐ 02357012 Identification and targeting of high risk subgroups in pediatric acute lymphoblastic leukemia: Ph‐like and Down Syndrome ALL Lombardia Andrea Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS Biondi Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 254 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02357013 MARIO NEGRI Atypical Hemolytic Uremic Syndrome (aHUS): Experimental protocol of patient monitoring by combined analysis of Eculizumab levels and its inhibitory effect and correlation with clinical parameters and C5b‐9 deposits on endothelial cells RF‐2013‐ 02357023 From micro‐GIST to overt GIST: dissection of the molecular alterations involved in GISTmalignant evolution RF‐2013‐ 02357024 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Bresin Elena Clinico‐ Immunology assistenzial e Hypersensitivity, Autoimmune, and Immune C.R.O. AVIANO Gasparotto Daniela Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS Targeting the Calcineurin‐GSK3 axis in T‐cell acute lymphoblastic leukemia I. O. V. Piovan Erich Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02357027 RANDOMIZED PLACEBO‐CONTROLLED STUDY OF LOW MOLECULAR WEIGHT HEPARIN (LMWH) FOR THE PREVENTION OF THROMBOEMBOLIC COMPLICATIONS IN NEWLY DIAGNOSED NON‐ HODGKIN LYMPHOMA PATIENTS (NHL) Piemonte Santi Roberto Mario Biomedica Vascular and Hematology Hemostasis and Thrombosis ‐ HT RF‐2013‐ 02357028 MOLECULAR DISSECTION OF THE PI3K/AKT PATHWAY IN GLIOBLASTOMA: IMPLICATIONS FOR THE DEVELOPMENT OF NOVEL TARGET THERAPIES BASED ON SMALL MOLECULES. CASA SOLLIEVO SOFFERENZA Parrella Paola Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP RF‐2013‐ 02357029 Exosomes omics: a vehicle for tumor‐stroma communication and clinical translation in pancreatic cancer Veneto Basso Daniela Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME RF‐2013‐ 02357031 Engineered UC‐MSCs in multiple myeloma treatment: a preclinical cytotherapy model for both killing of tumor cells and healing osteolytic bone lesions. Puglia SILVESTRIS FRANCESCO Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT RF‐2013‐ 02357034 Epigenetics in neurodegenerative dementias: circulating SANTA LUCIA cells and derived pluripotent stem cells (iPSCs) from patients to identify pathogenic mechanisms and potential biomarkers Fuso Andrea Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 255 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02357035 The role of vitamin D and B status on cellular aging and age‐related diseases Provincia autonoma Bolzano Herrmann Markus Clinico‐ Biology of Development assistenzial and Aging e Cellular Mechanisms in Aging and Development ‐ CMAD RF‐2013‐ 02357048 New Biomolecular tools for Murine Typhus Diagnosis Calabria LUCIANI FILIPPO Biomedica Infectious Diseases and Microbiology Clinical Research and Field Studies of Infectious Diseases ‐ CRFS RF‐2013‐ 02357049 Dissecting WT1 mutations in leukemia I. O. V. Tosello Valeria Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB RF‐2013‐ 02357054 REWIND ‐ Recovery of Equilibrium during Walking IN patients with stroke‐related Diseases SANTA LUCIA Paolucci Stefano Clinico‐ Emerging Technologies and Brain Disorders and assistenzial Training in Neurosciences Related e Neurosciences Fellowship ‐ F01 RF‐2013‐ 02357057 Calcineurine inhibitors (CNIs) monitoring in peripheral blood mononuclear cells (PBMCs) in the clinical care of de‐novo heart transplanted patients Piemonte Rinaldi Mauro Clinico‐ Interdisciplinary Molecular assistenzial Sciences and Training e Fellowship: Chemical and Bioanalytical RF‐2013‐ 02357066 The Impact of Hypoxia and MicroRNA Control on Dystrophin‐associated Protein Complex (DPC‐)proteins during Neuronal Differentiation: Implications for Cognitive Deficits in Duchenne Muscular Dystrophy Istituto Superiore di Sanita' Macioce Pompeo Biomedica Molecular, Cellular, and Developmental Neuroscience Neurogenesis and Cell Fate ‐ NCF RF‐2013‐ 02357070 Role of migrants in tuberculosis, vectors and vector‐ borne disease spread IZSSI Caracappa Santo Biomedica Infectious Diseases and Microbiology Clinical Research and Field Studies of Infectious Diseases ‐ CRFS RF‐2013‐ 02357071 Acquisition, analysis and management of clinical, social and geo‐medical data aiming at studying and developing epidemiological models of diseases with high social and economic impact in Calabria region Calabria Cuda Giovanni Biomedica Population Sciences and Epidemiology Social Sciences and Population Studies ‐ SSPS Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 256 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02357072 Identification of causative gene(s) for rare enteric neuropathies by next generation sequencing and functional studies in zebrafish RF‐2013‐ 02357074 Inactivation of the tumor suppressor IRF‐1 by the IkappaB Istituto Superiore di Sanita' MARSILI kinase (IKK)‐epsilon in breast cancer: identification of druggable targets through proteomic analysis RF‐2013‐ 02357095 Cardiac and Vascular stress echo during normobaric hypoxia in coronary heart disease patients and healthy subjects: A new non‐invasive, low cost test to improve safety of recreational mountain climbers and workers at high altitude. Valle d'Aosta RF‐2013‐ 02357096 LIVER REGENERATION ENHANCEMENT: PRE‐ CLINICAL AND FIRST IN MAN CLINICAL STUDY TO ASSESS THE SAFETY AND EFFICACY OF HUMAN ADIPOSE DERIVED MESENCHYMAL STEM CELLS. RF‐2013‐ 02357100 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Ivana Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD GIULIA Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC GIARDINI GUIDO Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS Sicilia Spada Marco Biomedica Surgery, Anesthesiology, and Trauma ‐ SAT New perspectives in the prevention of Diabetes dependent cognitive decline Calabria Arturi Franco Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Diabetes, Metabolism, Nutrition and Obesity Small Business SEP (EMNR E10 B) RF‐2013‐ 02357106 Effect of CHRNA7 genotypes on the cognitive response to acetylcholinesterase inhibitor (AChEI) treatment (Donepezil) at Different Stages of Alzheimer's Disease SAN RAFFAELE PISANA RUSSO PATRIZIA Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Cell Death in Neurodegeneration ‐ CDIN RF‐2013‐ 02357108 Epithelial ovarian cancer: affecting tumor growth by targeting aberrant metabolism ISTITUTO TUMORI MILANO Bagnoli Marina Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT RF‐2013‐ 02357123 The Pharmacometrics for NeuroBlastoma (P4NB) Project: GASLINI Integrated Systems Biology and Quantitative Analyses to Guide Personalized Treatment and Orphan Drug Development in High Risk NB garaventa alberto Biomedica Oncology 2 ‐ Translational Clinical Developmental Therapeutics ‐ DT GASLINI Matera Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Surgical Sciences, Biomedical Imaging, and Bioengineering Pagina 257 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02357128 DON GNOCCHI Effects of a web‐controlled home‐based exercise intervention in modulating endothelial dysfunction and related humoral markers in coronary patients across the spectrum of abnormal glucose metabolism. Ferratini Maurizio Biomedica RF‐2013‐ 02357135 The first Moyamoya disease Italian Network: the CARLO BESTA integration of clinics with genetic and cellular approaches for understanding the pathophysiology of this rare and complex disease Bersano Anna Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Brain Injury and Neurovascular Pathologies ‐ BINP RF‐2013‐ 02357138 Effectiveness of a cognitive‐behavioral and lifestyle intervention in reducing cardiovascular risk factors and cardiovascular morbidity among patients with severe mental illness treated with antipsychotics Lombardia cerveri giancarlo Clinico‐ Risk, Prevention and assistenzial Health Behavior e SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan ‐ TPM1 RF‐2013‐ 02357139 Development and characterization of non‐invasive and clinically relevant mouse models of drug resistant leukemia: cellular, molecular, and functional studies directed to the identification of therapeutic targets for chemotherapy‐resistant human leukemia c IZSLER LOMBARDI GUERINO Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP RF‐2013‐ 02357142 Aberrant genes on chromosome 10 open new perspectives ISTITUTO DERMOPATICO into the molecular pathogenesis of Cutaneous T‐cell DELL'IMMACOLATA Lymphoma Russo Giandomenico Biomedica Oncology 1 ‐ Basic Translational Cancer Genetics ‐ CG RF‐2013‐ 02357158 MOLECULAR ANALYSIS AND HISTOLOGICAL Lazio CHARACTERIZATION OF MELANOCYTIC METASTATIC PHENOTYPE ACCORDING TO THE EXPRESSION OF MCAM/MUC18 CELLULAR ADHESION MOLECULE, METALLOPROTEINASES AND ANGIOGENIC FACTORS Bianchi Luca Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02357172 Beta‐actin oxidation: a new predictive biophysical‐ biochemical marker for autism Hayek Joussef Biomedica Biochemistry and Biophysics of Membranes ‐ BBM Toscana Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Cardiovascular and Respiratory Sciences Clinical and Integrative Cardiovascular Sciences ‐ CICS Biological Chemistry and Macromolecular Biophysics Pagina 258 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02357174 Istituto Superiore di Sanita' Palmisano Strengthening the italian participation to independent, nonprofit randomized clinical trials in Europe by supporting and implementing ItaCRIN, the italian hub of ECRIN consortium. Lucia Clinico‐ Healthcare Delivery and assistenzial Methodologies e Biostatistical Methods and Research Design ‐ BMRD RF‐2013‐ 02357177 Familial breast and melanoma diseases: common and different genetic and epigenetic features ONCOLOGICO DI BARI Tommasi Stefania Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02357188 Design, Synthesis and Preclinical evaluation of novel peptidomimetic active against ESKAPE pathogens and agent of zoonosis Emilia‐Romagna BARONI MARIA CRISTINA Biomedica Infectious Diseases and Microbiology Drug Discovery and Mechanisms of Antimicrobial Resistance ‐ DDR RF‐2013‐ 02357189 Enabling BCI‐assisted bedside detection of intention to communicate and communication in functional Locked‐ in syndromes after acquired brain injury SANTA LUCIA Formisano Rita Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02357195 New technolgies in the diagnosis and surveillance of invasive bacterial infections in Italy:an essential tool in the planning and monitoring of prevention strategies Toscana Resti Massimo Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS RF‐2013‐ 02357212 IMMUNOLOGICAL MECHANISMS IMPLICATED IN THE DEVELOPMENT OF HYPERTENSION AND MORPHOFUNCTIONAL MICROVASCULAR ALTERATIONS. Lombardia Rizzoni Damiano Biomedica Clinical and Integrative Cardiovascular Sciences ‐ CICS RF‐2013‐ 02357219 Tailored communication strategies to improve lifestyle habits in women at intermediate/high risk of developing breast cancer: a Randomised Control Trial in a screening setting. Piemonte Giordano Livia Clinico‐ Risk, Prevention and assistenzial Health Behavior e SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan ‐ TPM1 RF‐2013‐ 02357227 Unicellular eukaryotes as biomarkers of intestinal dysbiosis in patients with Irritable Bowel Syndrome (Diarrhoea prevalent, IBS‐D) and Functional Diarrhoea Istituto Superiore di Sanita' Simone Mario Caccio Biomedica Infectious Diseases and Microbiology Fellowship ‐ F13 Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Cardiovascular and Respiratory Sciences Infectious Diseases and Microbiology Classificazione 2° liv. Pagina 259 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02357230 Targeting hematological malignancies by TCR gene edited memory stem T cells SAN RAFFAELE MILANO Bonini RF‐2013‐ 02357231 Clinical utility of a next generation sequencing‐based "oncochip" for therapeutic decision in metastatic breast cancer I.E.O. CURIGLIANO GIUSEPPE Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC RF‐2013‐ 02357236 Inflammasome and bladder cancer: impacts on diagnosis and post‐surgical management Umbria Mearini Ettore Biomedica Cancer Immunopathology and Immunotherapy ‐ CII RF‐2013‐ 02357243 "Primary care management" to address patients with complex health care needs in an area‐based health care system Veneto Toffanin Roberto Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02357244 Prognostic evidence in Health Technology Assessment Agenzia per i Servizi Sanitari Regionali Jefferson Tom Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02357254 Identification of new therapeutical targets of cancer stem I.E.O. cells: study of the mechanistics of mitotic spindle alignment to cortical polarity in mammary stem cell asymmetric divisions MAPELLI MARINA Biomedica Biological Chemistry and Macromolecular Biophysics Macromolecular Structure and Function C ‐ MSFC RF‐2013‐ 02357255 A comprehensive NGS‐based approach for the definition of the molecular bases of the hereditary dysmyelinating disorders of the central nervous system Di Bella Daniela Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD RF‐2013‐ 02357262 E‐cadherin and signalling pathway components for using C.R.O. AVIANO in clinic as diagnostic and prognosticvalue in gastric carcinoma De Re Valli Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02357263 One Health approch to evaluate Hepatitis E virus infection burden in humans and swine in Marche and Lazio regions, risk factors and pathogenic potential of different virus strain Duranti Anna Biomedica Infectious Diseases and Microbiology Clinical Research and Field Studies of Infectious Diseases ‐ CRFS CARLO BESTA IZSUM Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Chiara Biomedica Classificazione 1 Liv. Classificazione 2° liv. Oncology 2 ‐ Translational Clinical Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII Pagina 260 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02357266 Unravelling the impact of different treatment strategies on intra‐clonal heterogeneity in Multiple Myeloma RF‐2013‐ 02357270 AREA P.I. Classificazione 2° liv. Genes, Genomes and Genetics Genetic Variation and Evolution ‐ GVE Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB Biomedica Musculoskeletal, Oral and Skin Sciences Oral, Dental and Craniofacial Sciences ‐ ODCS Laura Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN Noonan Douglas M Biomedica Vascular and Hematology Vascular Biology Special Emphasis Panel ‐ SEVB Toscana GORINI GIUSEPPE Clinico‐ Risk, Prevention and assistenzial Health Behavior e Risk, Prevention and Intervention for Addictions ‐ RPIA High‐risk epigenetic biomarkers in the onset of malignant pleural mesothelioma in asbestos exposed subjects ONCOLOGICO DI BARI Galetta Domenico Biomedica Cancer Biomarkers ‐ CBSS RF‐2013‐ 02357302 Comparing effectiveness and cost‐effectiveness of social‐ care health‐care trajectories experienced by frail older people in real‐life Lombardia Annoni Giorgio Clinico‐ Population Sciences and assistenzial Epidemiology e Social Sciences and Population Studies ‐ SSPS RF‐2013‐ 02357304 Potential use of Circulating Melanoma Cells (CMCs) in dog: a spontaneous cancer model for studying metastasis IZSVE VASCELLARI MARTA Biomedica Animal Health ‐ ANHE Emilia‐Romagna Biomedica Classificazione 1 Liv. Cavo Michele PROSTATE CANCER: A STUDY ON THE MOLECULAR IRCCS AOU San Martino‐ MECHANISMS UNDERLYING THE DEVELOPMENT OF IST (Genova) CASTRATION‐RESISTANT PHENOTYPE Balbi Cecilia Serenella Biomedica RF‐2013‐ 02357272 A promising treatment option for Bisphosphonate‐ Related Osteonecrosis of the Jaw (BRONJ) based on osteoblasts/osteoclasts co‐culturing on multifunctional scaffolds. Abruzzo Adriano Piattelli RF‐2013‐ 02357289 Cellular senescence biomarkers in peripheral blood mononuclear cells (PBMC) of Alzheimer Disease I.N.R.C.A. Costarelli RF‐2013‐ 02357291 Innovative anti‐angiogenetic compounds for human diseases MULTIMEDICA RF‐2013‐ 02357293 The Italian National Quitline and three Regional Telephone Services to follow smokers in their quit attempts through telephone counselling and facilitating contacts with local Tobacco Cessation Services RF‐2013‐ 02357301 Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Oncology 2 ‐ Translational Clinical Veterinary Pagina 261 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02357306 Emilia‐Romagna Impact of an Enhanced Recovery After Surgery (ERAS) program on physical performance and muscle strength in elderly patients undergoing elective colorectal resection for cancer VOLPATO STEFANO Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Surgery, Anesthesiology, and Trauma ‐ SAT RF‐2013‐ 02357307 Expression and function of P2 receptors in human psoriatic keratinocytes. Study of their role in psoriasis pathogenesis and research of new potential therapeutic targets ISTITUTO DERMOPATICO DELL'IMMACOLATA Albanesi Cristina Biomedica Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ‐ ACTS RF‐2013‐ 02357321 Development of aptamers as novel diagnostic and therapeutic tools for Diabetes Mellitus HUMANITAS Malosio Maria Luisa Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Clinical Molecular Imaging and Probe Development ‐ CMIP RF‐2013‐ 02357322 Effect of stress ( and psychological factors) on immune and endocrine systems in patients affected by breast carcinoma and hormone‐correlated tumours. I.N.R.C.A. Vespa Anna Clinico‐ Biobehavioral and assistenzial Behavioral Processes e Biobehavioral Mechanisms of Emotion, Stress and Health ‐ MESH RF‐2013‐ 02357323 Identification of new molecular therapeutic targets in Medullary thyroid cancer using next generation sequencing‐based approaches CASA SOLLIEVO SOFFERENZA Torlontano Massimo Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02357324 Pharmacogenetic modulation of Ras‐ERK signalling in mouse models of striatal neurodegeneration and cognitive decline SAN RAFFAELE MILANO Brambilla Riccardo Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND RF‐2013‐ 02357325 BRIDGING THE TUMOR MACRO‐ AND MICRO‐ ENVIRONMENT: THE ROLE OF METABOLIC AND NEUROENDOCRINE FACTORS IN BREAST CANCER PROGRESSION Istituto Superiore di Sanita' Cirulli Francesca Biomedica Biobehavioral and Behavioral Processes Biobehavioral Mechanisms of Emotion, Stress and Health ‐ MESH RF‐2013‐ 02357337 PYB ‐ Protect Your Back (Effectiveness of Back Protector in preventing spinal cord injuries) Istituto Superiore di Sanita' Giustini Marco Biomedica Risk, Prevention and Health Behavior Psychosocial Development, Risk, and Prevention ‐ PDRP Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 262 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA RF‐2013‐ 02357340 Virological and molecular characteristics of Human Papillomavirus (HPV) : a study on prevalence and persistence in oral cavity and ano‐genital sites in HIV‐ positive patients SPALLANZANI Garbuglia Anna Rosa Biomedica Infectious Diseases and Microbiology Virology A and B Study Sections ‐ VIRA and VIRB RF‐2013‐ 02357342 DEVELOPMENT AND VALIDATION OF A NOVEL LABORATORY IN VITRO ASSAY AIMED AT PREDICTING ALLERGIC OR TOLERANT RESPONSES TO CONTACT ALLERGENS SAN GALLICANO Bordignon Valentina Biomedica Immunology Hypersensitivity, Autoimmune, and Immune RF‐2013‐ 02357357 A novel player in ovarian cancer vasculature: biological role and therapeutic implications I.E.O. Cavallaro Ugo Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME RF‐2013‐ 02357370 Serum tryptase and chymase: new biomarkers in patients Lombardia with acute coronary syndrome. Losappio Laura Michelina Clinico‐ RF‐2013‐ 02357373 CARDIOVASCULAR SCREENING OF LONG TERM CANCER SURVIVORS AFTER CHEST RADIATION THERAPY. C.R.O. AVIANO Lestuzzi RF‐2013‐ 02357375 Gut Bacteria (microbiOta) in HepAtic EncephaLopathy and Possible Utility of its Modulation (the GOAL study) DE BELLIS RF‐2013‐ 02357376 Serum sialic‐acid‐binding immunoglobulin‐like lectin‐7 (Siglec‐7) as a biomarker of liver inflammation and fibrosis in hepatitis C and other chronic viral infections RF‐2013‐ 02357377 Dissecting Kabuki syndrome by cellular modelling and genome wide analysis P.I. Classificazione 1 Liv. Classificazione 2° liv. Cardiovascular and assistenzial Respiratory Sciences e Myocardial Ischemia and Metabolism ‐ MIM Chiara Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS Leandro Gioacchino Clinico‐ Infectious Diseases and assistenzial Microbiology e Host Interactions with Bacterial Pathogens ‐ HIBP SAN MATTEO MONDELLI MARIO UMBERTO Biomedica Infectious Diseases and Microbiology Clinical Research and Field Studies of Infectious Diseases ‐ CRFS CASA SOLLIEVO SOFFERENZA Merla Giuseppe Biomedica Genes, Genomes and Genetics Molecular Genetics ‐ MGA Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 263 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02357382 Sicilia NEOADJUVANT CHEMOTHERAPY AND RADICAL SURGERY IN TREATMENT OF LOCALLY ADVANCED CERVICAL CARCINOMA: 18F‐FDG‐PET/CT AND MOLECULAR BIOLOGY PREDICTIVE VALUE IN EARLY AND LATE ASSESSMENT OF RADICAL SURGERY FEASIBILITY AND ITS SURVIVAL IMPACT scollo paolo Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02357385 Application of a standardized ERAS (Enhanced Recovery SAN RAFFAELE MILANO After Surgery) perioperative pathway in resective esophageal surgery: effects on morbility, mortality, lenght of hospital stay, costs, and quality of life Rosati Riccardo Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02357386 Role of serotonin in modulating L‐DOPA‐induced dyskinesia SANTA LUCIA Picconi Barbara Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02357389 Development of human Mesenchymal Stem Cell driven bone marrow microenvironments/niches supporting hemopoiesis and controlling hematopoietic and non‐ hematopoietic tumor growth in vivo IRCCS AOU San Martino‐ IST (Genova) Cancedda Ranieri Biomedica Cell Biology Intercellular Interactions ‐ ICI RF‐2013‐ 02357390 The PRECISE (PRocedural failurE after CardIovascular Surgery in the Elderly) project SAN DONATO Ranucci Marco Maria Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS RF‐2013‐ 02357392 The alpha‐Melanocyte Stimulating Hormone/ Peroxisome Proliferator Activated Receptor‐gamma connection: new insights on melanoma risk assessment SAN GALLICANO Maresca Vittoria Biomedica Cellular Signaling and Regulatory Systems ‐ CSRS RF‐2013‐ 02357393 A multidisciplinary investigation for the improvement of aortic endografting: from biomedical engineering concepts to clinical implementation SAN DONATO Trimarchi Santi Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Cell Biology Classificazione 2° liv. Computational modeling and sciences for biomedical and clinical applications ‐ ZRCM Pagina 264 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02357404 Istituto Superiore di Sanita' Brambilla Emerging health&food safety/security risks from combined organic chemical, pharmaceutical, and microbial hazards from civil wastewater treatment plants sludges recycled as top soil improvers in agriculture: "SAFE‐SOIL". Gianfranco Biomedica Veterinary Food Safety ‐ FOSA RF‐2013‐ 02357406 Role of gene methylation in the risk of ischemic stroke Licia Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD RF‐2013‐ 02357409 Microglia/macrophages as cellular target of novel CXCR4 Istituto Superiore di Sanita' Ajmone Cat antagonist and radiotherapy combined treatment in glioma models Maria Antonietta Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT RF‐2013‐ 02357410 Vascular complications in patients with chronic myeloid leukemia: evaluation of possible adverse effects of nilotinib on endothelial function. IRCCS AOU San Martino‐ IST (Genova) Palombo Domenico Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT RF‐2013‐ 02357417 T10 cellular immunotherapy in kidney transplantation to induce donor‐specific tolerance SAN RAFFAELE MILANO Caldara Rossana Clinico‐ Immunology assistenzial e Transplantation, Tolerance and Tumor Immunology ‐ TTT RF‐2013‐ 02357452 Advanced MRS, ASL perfusion and structural MRI in pediatric migraine: a longitudinal study and correlations with clinical and neurophysiological findings. OSPEDALE BAMBINO GESU' Valeriani Massimiliano Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02357453 Targeted exome sequencing to identify novel putative genetic variants associated with Gestational Diabetes Mellitus Calabria Andreozzi Francesco Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular Aspects of Diabetes and Obesity ‐ CADO RF‐2013‐ 02357463 From lifestyle to mitochondrial benefits: study on a combined therapeutic approach toHuntington's disease Istituto Superiore di Sanita' Visentin Sergio Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN RF‐2013‐ 02357468 Differential Roles of Left & Right Anterior/Polar Prefrontal Cortex (BA 10/11) in Real‐World Problem Solving S.CAMILLO Vinod Biomedica Biobehavioral and Behavioral Processes Cognition and Perception ‐ CP NEUROMED Iacoviello Goel Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 265 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02357480 Optimizing management of severe infections due to drug Campania resistant gram‐negative bacteria in hospitalised patients RF‐2013‐ 02357481 Extensive genetics and functional neuroimaging in ALS: revealing mechanisms of disease progression (GeNeuPro‐ ALS). RF‐2013‐ 02357484 A randomized controlled clinical trial to assess the role of Istituto Superiore di Sanita' Baroncelli mesalazine as a modulator of gut microbial translocation and systemic immune activation in chronically infected, ART treated HIV subjects RF‐2013‐ 02357490 Prognostic value of lung ultrasound in patients admitted for congestive heart failure: a prospective observational study Lombardia RF‐2013‐ 02357491 Development and production of a novel decellularized dermal matrix for reconstructive surgery procedures. RF‐2013‐ 02357494 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Durante Mangoni Emanuele Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS Mandich Paola Biomedica Genetics of Health and Disease ‐ GHD Silvia Clinico‐ AIDS and Related Research assistenzial e AIDS Clinical Studies and Epidemiology ‐ ACE Montano Nicola Biomedica Cardiovascular and Respiratory Sciences Cardiovascular Sciences Small Business SECS Piemonte Castagnoli Carlotta Biomedica Bioengineering Sciences and Technologies Biomaterials and Biointerfaces ‐ BMBI A bench‐to‐bedside approach to the rational use of targeted therapies in ¿ultra‐rare¿entities: the case of extraskeletal myxoid chondrosarcoma and antiangiogenics ISTITUTO TUMORI MILANO Stacchiotti Silvia Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC RF‐2013‐ 02357496 An integrated network of centers of excellence to perform a series of clinical studies to assess efficacy, efficiency, safety, and appropriate clinical indications of extracorporeal membrane oxygenation (ECMO) in patients with severe pulmonary failure Piemonte Fanelli Vito Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Lung Injury, Repair, and Remodeling ‐ LIRR RF‐2013‐ 02357497 Improving therapeutic appropriateness of Multiple Sclerosis treatments using biological approaches to personalize therapy and save pharmaceutical spending Piemonte Bertolotto Antonio Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroimmunology and Brain Tumors ‐ CNBT IRCCS AOU San Martino‐ IST (Genova) Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Genes, Genomes and Genetics Pagina 266 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02357498 Identification of a biological network as potential useful tool for monitoring, preventing and developing personalised treatments for sporadic thoracic aortic aneurysm Sicilia Ruvolo Giovanni Biomedica RF‐2013‐ 02357500 Autologous Adipose Tissue Derived Mesenchymal Stem Cells Enrichment and Isolation for the Treatment of Patients with Degenerative Hip Osteoarthritis Piemonte Ferracini Riccardo Clinico‐ Musculoskeletal, Oral and assistenzial Skin Sciences e Skeletal Biology Structure and Regeneration ‐ SBSR RF‐2013‐ 02357501 Unraveling the molecular mechanisms that underlie brain metastasis formation from breast cancer. I.E.O. PELICCI GIULIANA Biomedica Oncology 1 ‐ Basic Translational Tumor Progression and Metastasis ‐ TPM2 RF‐2013‐ 02357505 Novel therapeutic strategies for Frontotemporal Lobar Degeneration by targeting progranulin‐related inflammatory pathways MARIO NEGRI ALBANI DIEGO Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02357506 Feasibility of LINAC‐based StereoBody Radiotherapy (SBRT) in 3 fractions for low to intermediate/low risk prostate cancer REGINA ELENA Sanguineti Giuseppe Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC RF‐2013‐ 02357510 Italian study on gene‐environment interactions in lymphoma aetiology: translational aspects Toscana Miligi Lucia Biomedica Population Sciences and Epidemiology Epidemiology of Cancer ‐ EPIC RF‐2013‐ 02357512 Dysregulated JAK function in acute lymphoblastic leukemia Istituto Superiore di Sanita' Flex Elisabetta Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC RF‐2013‐ 02357515 Near‐road exposure and health effects of Ultrafine Particles INAIL gariazzo claudio Biomedica Population Sciences and Epidemiology Social Sciences and Population Studies ‐ SSPS RF‐2013‐ 02357518 Emilia‐Romagna Ontology and readmission: role of e‐health communications technologies in frail patients discharged from internal medicine department FABBIAN FABIO Clinico‐ Healthcare Delivery and assistenzial Methodologies e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Vascular and Hematology Vascular Cell and Molecular Biology ‐ VCMB Community‐Level Health Promotion ‐ CLHP Pagina 267 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02357520 Occurrence of Ostreopsis genus blooms in Tyrrhenian sea: tools to prevent human intoxication due to palytoxins contaminated seafood. Istituto Superiore di Sanita' Cozzi RF‐2013‐ 02357522 Immuno‐modulatory mechanisms may be relevant in shaping the bone marrow microenvironment in patients with primary myelofibrosis: evaluation of the possible role of mesenchymal stromal cells. SAN MATTEO RF‐2013‐ 02357523 Ultra‐high‐field (UHF) sodium (23Na) MRI imaging as noninvasive biomarker for measuring structural changes and assessing prognosis of pathology in pediatric brain tumors STELLA MARIS RF‐2013‐ 02357524 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Loredana Biomedica Veterinary Food Safety ‐ FOSA Massa Margherita Biomedica Immunology Cellular and Molecular Immunology B ‐ CMIB Tosetti Michela Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Medical Imaging ‐ MEDI UNDERSTANDING SPACE AND ACTION PERCEPTION Veneto IN SPINAL CORD INJURED PEOPLE: NEUROSCIENTIFIC AND TRANSLATIONAL IMPLICATIONS moro valentina Biomedica Integrative, Functional, and Cognitive Neuroscience Cognitive Neuroscience ‐ COG RF‐2013‐ 02357527 Emilia‐Romagna MUTATIONAL ANALYSIS, NEOANGIOGENESIS, AND CELL LINEAGE TRACING AS NEW COMPLEMENTARY APPROACHES TO DISCRIMINATE THE RISK OF MALIGNANT TRANSFORMATION IN ADENOMATOUS LIVER LESIONS. D'errico Antonietta Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02357530 Peripheral blood total nucleated cells for the treatment of ISTITUTO critical limb ischemia DERMOPATICO DELL'IMMACOLATA Germani Antonia Biomedica Clinical and Integrative Cardiovascular Sciences ‐ CICS RF‐2013‐ 02357531 Burden of Cancer in three Italian population‐based cancer registries and attributable fraction to main risk factors Istituto Scientifico Romagnolo falcini fabio Clinico‐ Population Sciences and assistenzial Epidemiology e Epidemiology of Cancer ‐ EPIC RF‐2013‐ 02357532 Computerized Interconnected Infusion Safety Systems (CIISSs) for preventing administration errors Istituto Scientifico Romagnolo Zeneli Anita Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Cardiovascular and Respiratory Sciences Pagina 268 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO RF‐2013‐ 02357534 Toll Like receptors (TLRs) a new biomarker for understanding oral and oro‐pharyngeal carcinogenesis and tumor progression related to Human Papillomavirus (HPV) infection?A multicentre study on low/high grade epithelial dysplasia and cancer HPV+ve versu Sicilia RF‐2013‐ 02357535 Dietary advanced glycation end products and cardiovascular risk: animal and human studies RF‐2013‐ 02357538 RF‐2013‐ 02357539 RF‐2013‐ 02357541 DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. giuseppina Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS Istituto Superiore di Sanita' Riganò Rachele Biomedica Cardiovascular and Respiratory Sciences Clinical and Integrative Cardiovascular Sciences ‐ CICS Understanding the molecular bases of intellectual disability and autism spectrum disorders associated with macrocrania/macrosomia (IAMM). Istituto Superiore di Sanita' cordeddu viviana Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD Role of extracellular vesicles in bone tumour pathogenesis: implications for therapy OSPEDALE BAMBINO GESU' Muraca Maurizio Biomedica Musculoskeletal, Oral and Skin Sciences Skeletal Biology Development and Disease ‐ SBDD Toscana Gambineri Eleonora Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD Musculoskeletal, Oral and Skin Sciences Skeletal Muscle Biology and Exercise Physiology ‐ SMEP campisi "Characterization of myelopoiesis disorders: unrevealing the role of GATA2 and related factors in predicting patients' clinical outcome and establishing a timely treatment" RF‐2013‐ 02357542 Novel therapeutic approaches to slow muscular dystrophy progression: identification ofpotential targets through molecular dissection of the alterations in mitochondrial biogenesisand in its epigenetic control Lombardia Clementi Emilio Giuseppe Ignazio Biomedica RF‐2013‐ 02357546 Impact and effectiveness of clinical pharmacyst's interventions in the multidisciplinary care of HIV infected patients with comorbidities including cancer, treated with polypharmacy. A randomized controlled clinical trial to assess health outcomes by adop C.R.O. AVIANO Baldo Paolo Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02357548 ASSESSMENT OF DIFFERENT WHEAT CULTIVAR EFFECTS IN A MOUSE MODEL OF ENTEROPATHY Campania RIEGLER GABRIELE Biomedica Gastrointestinal Mucosal Pathobiology ‐ GMPB Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Digestive, Kidney and Urological Systems Pagina 269 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02357552 ASSESSMENT OF THE PATHOBIOLOGICAL ROLE, DIAGNOSTIC AND PREDICTIVE VALUE OF THE NOVEL CYTOKINE IL‐30 IN PROSTATE CANCER RF‐2013‐ 02357555 Alloimmunity and infection: insight into pathogen‐driven SAN MATTEO alloreactivity to develop preventive strategies for late kidney graft failure RF‐2013‐ 02357557 Intimate Partner Violence and Woman's Mental, Social and Physical Well‐being: analysis of risk factors and the bio‐bank for epigenetic studies Liguria RF‐2013‐ 02357558 Identification of nuclear microRNAs affecting hematopoietic and neuronal cell differentiation and tumorigenesis RF‐2013‐ 02357567 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Di Carlo Emma Biomedica COMOLI PATRIZIA Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Pathobiology of Kidney Disease ‐ PBKD PIERLUIGI DANIELA Clinico‐ Population Sciences and assistenzial Epidemiology e Behavioral Genetics and Epidemiology ‐ BGES Istituto Superiore di Sanita' Pelosi Elvira Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP Study of molecular mechanisms underlying Alternating Hemiplegia of childhood by a novel in vitro model of human neuronal cells expressing ATP1A3 gene mutations Lazio Gurrieri Fiorella Biomedica Molecular, Cellular, and Developmental Neuroscience Neurotransporters, Receptors, Channels and Calcium Signaling ‐ NTRC RF‐2013‐ 02357574 Artificial neural networks and risk stratification tools for syncope in the emergency department Liguria Brignole Michele Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Cardiovascular Sciences Small Business SECS RF‐2013‐ 02357576 Circulating endothelial progenitor cells as potential predictive and prognostic markers inmetastatic colorectal cancer patients Toscana CAPORALE ROBERTO Biomedica Cancer Biomarkers ‐ CBSS RF‐2013‐ 02357579 High definition Video Thermography (VTG): a new method of imaging in paraclinical diagnosis of Non‐ Melanoma Skin Cancers and in the "Skin Cancerization Field" SAN GALLICANO LAINO LUIGI Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Oncology 2 ‐ Translational Clinical Small Business [SBIR/STTR] Radiation Therapy and Biology ‐SETA] RF‐2013‐ 02357581 INSECTS FOR FEED: EXPOSURE ASSESSMENT FROM FEED TO FOOD IZSPLV Marchis Daniela Biomedica Food Safety ‐ FOSA Abruzzo Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Oncology 1 ‐ Basic Translational Oncology 2 ‐ Translational Clinical Veterinary Tumor Microenvironment ‐ TME Pagina 270 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO RF‐2013‐ 02357582 Facilitating stroke recovery through home‐ based rehabilitation training RF‐2013‐ 02357589 DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Paola Biomedica Healthcare Delivery and Methodologies Health Services Organization and Delivery ‐ HSOD In search of new drugs and drug‐targets for the diagnosis Istituto Superiore di Sanita' Sandini and therapy of Invasive Fungal Infections (IFIs) Silvia Biomedica Infectious Diseases and Microbiology Pathogenic Eukaryotes ‐ PTHE RF‐2013‐ 02357606 Estimation of human health risk to methyl‐mercury: hair IZSPLV and nail as noninvasive bio indicators. Squadrone Stefania Biomedica Veterinary Food Safety ‐ FOSA RF‐2013‐ 02357612 Engineered nanoparticles: potential role in inducing bronchial hyperresponsiveness in exposed workers. SAN RAFFAELE PISANA CALZETTA LUIGINO Biomedica Bioengineering Sciences and Technologies Nanotechnology ‐ NANO RF‐2013‐ 02357613 Molecular bases for the identification of novel clinical approaches in patients with HPV‐induced cancer REGINA ELENA Mariani Luciano Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02357615 Development of new biguanides to target cancer metabolism IRCCS AOU San Martino‐ IST (Genova) Sambuceti Gianmario Biomedica Tumor Cell Biology ‐ TCB RF‐2013‐ 02357618 Oropharyngeal dysphagia in Myotonic Distrophies: diagnosis, management and implications for clinical practice and research CARLO BESTA Morandi Lucia Clinico‐ Musculoskeletal, Oral and assistenzial Skin Sciences e Skeletal Muscle Biology and Exercise Physiology ‐ SMEP RF‐2013‐ 02357619 Predicting chemotherapy toxicity in the elderly: a performance assessment of existing tools vs. aging biomarkers in the Ligurian population Liguria Repetto Lazzaro Biomedica Clinical Oncology ‐ CONC RF‐2013‐ 02357627 Preventing emergence and transmission of multiresistant OSPEDALE BAMBINO bacteria in hospitalized children: multi‐strategy study of GESU' risk factors and effectiveness of a tailored intervention Ciofi degli Atti Marta Luisa Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS RF‐2013‐ 02357628 ROLE OF THE IL‐31/IL‐31R AXIS IN B CELL MALIGNANCIES Corcione Biomedica Tumor Cell Biology ‐ TCB SANTA LUCIA GASLINI Marangolo Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Anna Oncology 1 ‐ Basic Translational Oncology 2 ‐ Translational Clinical Oncology 1 ‐ Basic Translational Pagina 271 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02357630 Role of the stromal‐derived factor‐1 (SDF‐1)/CXCR7 cross‐ Toscana talk between human hepatic stellate cells (hHSC) and cholangiocarcinoma (CCA) cells: a new target for CCA therapy? Gentilini Alessandra Biomedica RF‐2013‐ 02357634 Beyond the clinical evidence: a longitudinal study on the Toscana effect of physical rehabilitation in the muscle synergies and in functional brain activity in early Parkinson Disease patients Lucetti Claudio Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02357635 Study of the HIV‐1 cellular reservoir: impact of antiretroviral therapy on HIV‐1 DNA forms and identification of archived defective viral variants. SAN MATTEO Paolucci Stefania Clinico‐ AIDS and Related Research assistenzial e AIDS Molecular and Cellular Biology ‐ AMCB RF‐2013‐ 02357636 NEUROPATHIC PAIN IN GAUCHER DISEASE TYPE 1: CLINICAL AND MOLECULAR ASPECTS Friuli‐Venezia Giulia BEMBI BRUNO Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02357639 Surveillance of Multidrug Resistant Organisms (MDROs) Sicilia by a network‐based strategy: tracking molecular epidemiology and outcomes through the Neonatal Intensive Care Units Mammina Caterina Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS RF‐2013‐ 02357641 Pre‐treatment Immune Activation/Exhaustion as a Factor SPALLANZANI Affecting Post‐cART Immune Reconstitution Level and Function in Naive HIV‐infected Persons Undergoing Treatment Martini Federico Biomedica AIDS and Related Research AIDS Immunology and Pathogenesis ‐ AIP RF‐2013‐ 02357646 Patient‐derived xenografts to explore the usefulness of preclinical models on personalized medicine Emilia‐Romagna PANSINI Giancarlo Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT RF‐2013‐ 02357647 Molecular screening for a personalized treatment approach in hepatocellular carcinoma. Campania Morisco Filomena Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Cell Biology Molecular and Integrative Signal Transduction ‐ MIST Pagina 272 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02357656 The role of multiparametric Magnetic Resonance Imaging Emilia‐Romagna in the selection of patients with newly diagnosed prostate cancer at very low risk suitable for active surveillance: a prospective multi‐institutional study Schiavina Riccardo Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Urologic and Kidney Development and Genitourinary Diseases ‐ UKGD RF‐2013‐ 02357660 Towards safe, effective and feasible adoptive T cell therapy of solid tumors SAN RAFFAELE MILANO Mondino Anna Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII RF‐2013‐ 02357666 Molecular profiling of EGFR mutant lung carcinoma through analysis of liquid biopsies PASCALE Normanno Nicola Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02357667 COmparative Research of Different Antithrombotic Strategies in patients with acute coronary syndrome without persistent ST elevation, undergoing coronary revascularization (CORDAS Project): outcomes research and efficacy‐safety data. Emilia‐Romagna Cattabiani Maria Alberta Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS RF‐2013‐ 02357668 Assessment of the role of genes associated with breast cancer predisposition in the development of pediatric cancers ISTITUTO TUMORI MILANO Radice Paolo Biomedica Oncology 1 ‐ Basic Translational Cancer Genetics ‐ CG RF‐2013‐ 02357670 Deep sequencing and functional analysis of the miRNome Calabria in breast cancer progression: particular focus on exosomes, hypoxia and miR‐328 Iuliano Rodolfo Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP RF‐2013‐ 02357689 Prevention of post‐hospital syndrome in elderly through nutritional support Calabria Pujia Arturo Clinico‐ Biology of Development assistenzial and Aging e Aging Systems and Geriatrics ‐ ASG RF‐2013‐ 02357690 Preoperative computer‐assisted planning and intraoperative navigation in complex surgery of musculoskeletal tumors RIZZOLI Ruggieri Pietro Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC RF‐2013‐ 02357693 Decoding the transcriptome of circulating mesenchymal stem cells in patients with skeletal diseases and obesity. Veneto DALLE LUCA CARBONARE GIUSEPPE Biomedica Molecular Genetics ‐ MGA Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Genes, Genomes and Genetics Classificazione 2° liv. Pagina 273 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02357697 Extracellular microRNA in bronchoalveolar lavage for early detection of lung cancer IRCCS AOU San Martino‐ IST (Genova) Izzotti Alberto Biomedica RF‐2013‐ 02357699 Coming full circle on prenatal non‐invasive genetic tests: from health technology assessment, through recommendations for clinical practice/research, to support for decisions on coverage Emilia‐Romagna Ballini Luciana Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Pregnancy and Neonatology ‐ PN RF‐2013‐ 02357702 Crop biofortification with iodine: a new tool to fight iodine deficiency disorders. Toscana Tonacchera Massimo Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Endocrinology, Metabolism, Nutrition and Reproductive Sciences (EMNR) Integrated Review Group Fellowship Panel ‐ F06 RF‐2013‐ 02357703 In vivo guided regeneration of small diameter arteries (2‐ 5 mm) using biodegradable tubular scaffolds: role of endothelial progenitor cells in vasculogenesis. Veneto Vindigni Vincenzo Biomedica Bioengineering Sciences and Technologies Biomaterials and Biointerfaces ‐ BMBI RF‐2013‐ 02357723 PROJECT RANDOM: AXILLARY DISSECTION OR NOT IN SENTINEL NODE MACROMETASTASIS OF BREAST CANCER HUMANITAS tinterri corrado Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC RF‐2013‐ 02357730 Manipulate cytokines to shift the chronic inflammatory tone induced by prion disease as a route to clinical therapies HUMANITAS MATTEOLI MICHELA Biomedica Immunology Innate Immunity And Inflammation ‐ III RF‐2013‐ 02357738 The inflammasome inducer IFI16, an alarmin that initiates and propagates inflammation in Inflammatory Bowel Disease and its role as biomarker of disease phenotype heterogeneity and response to therapy. SAN DONATO VECCHI MAURIZIO Biomedica Digestive, Kidney and Urological Systems Gastrointestinal Mucosal Pathobiology ‐ GMPB RF‐2013‐ 02357739 Safe Nanotechnology: Assessing Nanoparticle Toxicity of Environmental Interest by an Integrated In Vitro Cell‐ Based Test Strategy. MAUGERI Coccini Teresa Biomedica Bioengineering Sciences and Technologies Nanotechnology ‐ NANO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS Pagina 274 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02357742 Epidemiology of Tinnitus in Italy using a Comprehensive Approach (ETICA) MARIO NEGRI Gallus Silvano Clinico‐ Population Sciences and assistenzial Epidemiology e Neurological, Aging and Musculoskeletal Epidemiology ‐ NAME RF‐2013‐ 02357743 Preclinical evaluation of ¿Janus faced¿ liposomes for the prevention of infectious complications during immunomodulatory therapy in autoimmune diseases. Lazio Ria Francesco Biomedica Immunology Innate Immunity And Inflammation ‐ III RF‐2013‐ 02357744 Different NHERF1 subcellular localizations in breast cancer: could genetic and posttranslational alterations shed light on its use in clinical practice? ONCOLOGICO DI BARI Mangia Annita Biomedica Oncology 1 ‐ Basic Translational Cancer Genetics ‐ CG RF‐2013‐ 02357746 cAMP‐PCT‐CGRP axis as a potential molecular target in the diagnosis and treatment of pre‐eclampsia BURLO GAROFALO Radillo Oriano Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Endocrinology, Metabolism, Nutrition and Reproductive Sciences (EMNR) Integrated Review Group Fellowship Panel ‐ F06 RF‐2013‐ 02357749 Lazio Health Technology Assessment and Comparative Effectiveness Research to appraise the real‐world value of an improved pharmacogenomics assay and of a metabolic assay for prediction of individual response to the anti‐ cancer agent 5‐Fluorouracil. SIMMACO MAURIZIO Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02357752 Istituto Oncologico Gastric cancer in the age of precision medicine: Linking genomic alterations to targeted drug response to validate Candiolo novel therapeutic strategies Comoglio Paolo Maria Biomedica Cancer Biomarkers ‐ CBSS RF‐2013‐ 02357754 TWIN ANALYSIS OF FINE NEEDLE ASPIRATION AND CIRCULATING TUMOR CELLS FOR GENOTYPE AND PHENOTYPE CHARACTERIZATION OF ADVANCED LUNG CANCER Mascalchi Mario Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Toscana Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Oncology 2 ‐ Translational Clinical Oncology 2 ‐ Translational Clinical Small Business [SBIR/STTR] Radiation Therapy and Biology ‐SETA] Pagina 275 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02357755 Diagnostic validation of circulating microRNAs as novel NSTEMI biomarkers in old and very old patients. I.N.R.C.A. Procopio Antonio Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Myocardial Ischemia and Metabolism ‐ MIM RF‐2013‐ 02357758 Changes in functional topography of the motor output after spinal cord injury SANTA LUCIA Cappellini Germana Clinico‐ Integrative, Functional, assistenzial and Cognitive Neuroscience e Sensorimotor Integration ‐ SMI RF‐2013‐ 02357765 A new organizational model for the management of the diabetic foot ulcers Sicilia Aliquo' Maria stella Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02357766 Fatty Liver Screening: Assessing the best effective screening program for Non Alcoholic Fatty Liver Disease (NAFLD) Sicilia Camma Calogero Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Clinical, Integrative and Molecular Gastroenterology ‐ CIMG RF‐2013‐ 02357776 Correlation between genotypic lineages and epidemiological and clinical features of Mycobacterium tuberculosis infections occurring in immigrant and authochtonous population living in the urban area of Milan, Italy. Lombardia Franzetti Fabio Clinico‐ Infectious Diseases and assistenzial Microbiology e Infectious Diseases and Microbiology Fellowship ‐ F13 RF‐2013‐ 02357777 Development, testing and dissemination of Communication strategies and tools for evidence‐based Informed Decision making in Italy (DeCIDe.It) Lazio Parmelli Elena Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02357778 Herpesvirus DNA in lower respiratory tract of intensive care unit patients: significance and implications. Toscana Peris Adriano Biomedica Infectious Diseases and Microbiology Virology A and B Study Sections ‐ VIRA and VIRB RF‐2013‐ 02357779 An Animal Behavior Analysis System exploiting the passive RFID Technology in UHF band Istituto Superiore di Sanita' Di Giannuario Amalia Biomedica Biobehavioral and Behavioral Processes Biobehavioral and Behavioral Processes Small Business Activities ‐SBBB RF‐2013‐ 02357784 Genomic analysis of human medulloblastomas and preclinical gene therapy study to target the regulation of cerebellar precursor migration Lazio Biomedica Oncology 1 ‐ Basic Translational Cancer Genetics ‐ CG Massimi Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Luca Classificazione 1 Liv. Classificazione 2° liv. Pagina 276 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02357787 Improving chronic pain treatment using new formulated topical nanomedicines. Istituto Superiore di Sanita' Pieretti Stefano Biomedica Bioengineering Sciences and Technologies Gene and Drug Delivery Systems ‐ GDD RF‐2013‐ 02357791 Connecting DNA repair and metabolic alterations of obesity in a search for predictive biomarkers Istituto Superiore di Sanita' Dogliotti Eugenia Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO RF‐2013‐ 02357795 TP53 Polymorphisms in glioblastoma and Head & Neck cancers: the clinical impact of correlation between genomic information and radio‐chemiotherapy treatment. Lombardia Buglione di Monale e Bastia Michela Biomedica Oncology 2 ‐ Translational Clinical Radiation Therapeutics and Biology ‐ RTB RF‐2013‐ 02357796 Lombardia Identification of new metabolic therapeutic targets of clear cell Renal Cell Carcinoma cancer stem cells through the study of lipid and glucose metabolism Bovo Giorgio Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP RF‐2013‐ 02357803 Clinical characterization and analytical confirmation of acute intoxications related to new psychoactive substances (NPS) of abuse identified through the specialist activity of a Poison Control Centre: defining a new emerging public health issue. Locatelli Carlo Alessandro Clinico‐ Risk, Prevention and assistenzial Health Behavior e Risk, Prevention and Intervention for Addictions ‐ RPIA RF‐2013‐ 02357804 New biomarker for thrombotic stroke in young patients: AUXOLOGICO diagnostic and pathogenic role of anti‐phopsholipid antibodies (aPL) specific for beta2 glycoprotein I (B2GPI) Domain I Meroni Pier Luigi Biomedica Hypersensitivity, Autoimmune, and Immune RF‐2013‐ 02357816 A pharmacogenetic approach to esophageal cancer: constitutive and somatic genetic variants as predictive, prognostic or disease risk markers Saggioro Daniela Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02357817 Exploring the susceptibility to fractures in youth for its SAN RAFFAELE MILANO prevention in adulthood: a phenotypic, functional and genomic characterization of bone fragility in children and adolescents and their families. Mora Stefano Biomedica Genetics of Health and Disease ‐ GHD MAUGERI I. O. V. Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Immunology Genes, Genomes and Genetics Pagina 277 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02357818 Dendritic cells engineered with the transcription factors IRF1 and IRF8 as an innovative tool for novel immunotherapy strategies. Istituto Superiore di Sanita' Fragale RF‐2013‐ 02357832 Early identification of left ventricular dysfunction due to anthracyclines and novel HER 2 targeted therapies in adjuvant treatment of breast cancer: role of new imaging techniques and biomarkers PASCALE RF‐2013‐ 02357834 Intestinal microbiome in Parkinson's disease: identification of disease biomarkers along the gut‐brain‐ axis RF‐2013‐ 02357838 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Alessandra Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME Nicola Biomedica Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF Provincia autonoma Trento Malaguti Maria Chiara Biomedica Genes, Genomes and Genetics Genomics, Computational Biology and Technology ‐ GCAT Detecting "brain at risk" for Vascular Dementia: the role of potential preclinical markers from Transcranial Magnetic Stimulation Sicilia Pennisi Giovanni Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroplasticity and Neurotransmitters ‐ CNNT RF‐2013‐ 02357849 Capacitive Coupling Electric Fields (CCEF) in the Treatment of Vertebral Compression Fractures (VCFs) Puglia piazzolla andrea Clinico‐ Musculoskeletal, Oral and assistenzial Skin Sciences e Musculoskeletal Tissue Engineering ‐ MTE RF‐2013‐ 02357851 Neuromelanin and iron dynamics in Parkinson¿s disease MONDINO and other synucleinopathies: investigation of potential neuroimaging markers of neurodegeneration and disease progression Blandini Fabio Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02357852 Predicting the individual's potential for functional recovery in Multiple Sclerosis using a combined neuroimaging and clinical approach Tomassini Valentina Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02357859 Sicilia HIGH‐RESOLUTION GENOMIC ANALYSIS AND BIOMARKER PROFILING OF AMYOTROPHIC LATERAL SCLEROSIS La Bella Vincenzo Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND SANTA LUCIA Maurea Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 278 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02357862 Bridging the gap between molecular mechanism and clinical trial, a promising approach to spinocerebellar ataxias sharing Purkinje neurons dark degeneration SAN RAFFAELE MILANO Casari Giorgio Nevio Biomedica RF‐2013‐ 02357869 Relationship between cognitive function, type 1 and type 2 diabetes Friuli‐Venezia Giulia Candido Riccardo Clinico‐ Integrative, Functional, assistenzial and Cognitive Neuroscience e Cognitive Neuroscience ‐ COG RF‐2013‐ 02357870 Reduction/elimination of exposure to ionizing radiation in interventional electrophysiologyprocedures in children using technology based on 3D mapping systems OSPEDALE BAMBINO GESU' Drago Fabrizio Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Electrical Signaling, Ion Transport, and Arrhythmias ‐ ESTA RF‐2013‐ 02357874 IMPROVEMENT OF PET‐2 PROGNOSTIC IMPACT FOR Sicilia A TAILORED THERAPY FOR HODGKIN LYMPHOMA CONSOLI UGO Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02357876 Utility of liquid biopsy in the management of early stage and advanced colorectal cancer (CRC) patients Sicilia BAZAN VIVIANA Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02357877 PAIN ASSOCIATED CORTICAL HEMODYNAMIC PERTURBATION IN PRETERM NEWBORNS AND ITS RELATION WITH SUCCESSIVE NEURODEVELOPMENTAL INJURIES BURLO GAROFALO Bembich Stefano Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Developmental Brain Disorders ‐ DBD RF‐2013‐ 02357879 Levels of miRna from serum exosomes as potential predictive biomarkers of clinical outcome in pancreatic ductal carcinoma patients ONCOLOGICO DI BARI Silvestris Nicola Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02357884 Risk assessment for and strategies to reduce perioperative Friuli‐Venezia Giulia complications and organ damage for patients undergoing cardiac surgery Zecchin Massimo Biomedica Cardiovascular and Respiratory Sciences Clinical and Integrative Cardiovascular Sciences ‐ CICS RF‐2013‐ 02357886 Mutations of cytochrome c associate with respiration defects and peculiar alterations of apoptotic pathways: pathogenetic implications in Thrombocytopenia 4 and Myelodysplastic Syndromes. PECCI ALESSANDRO Biomedica Vascular and Hematology Hemostasis and Thrombosis ‐ HT SAN MATTEO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN Pagina 279 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02357887 Next Generation sequencing in Midline Defects associated with hypopituitarism GASLINI Maghnie RF‐2013‐ 02357888 Tranexamic acid for hyperacute primary IntraCerebral Hemorrhage ‐ Italy (TICH 2‐Italy) Lombardia RF‐2013‐ 02357890 Role of the Transglutaminase type 2 (TG2) in the pathogenesis of M. tuberculosis RF‐2013‐ 02357892 Classificazione 1 Liv. Classificazione 2° liv. Mohamad Clinico‐ Genes, Genomes and assistenzial Genetics e Genetics of Health and Disease ‐ GHD Ciccone Alfonso Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Brain Injury and Neurovascular Pathologies ‐ BINP SPALLANZANI Piacentini Mauro Biomedica Infectious Diseases and Microbiology Host Interactions with Bacterial Pathogens ‐ HIBP Augmentation of nerve regeneration by iron oxide nanoparticles and electromagnetic field: a study in rat median nerve lesion Toscana Rossi Bruno Biomedica Bioengineering Sciences and Technologies Nanotechnology ‐ NANO RF‐2013‐ 02357893 Depicting common molecular mechanisms of liver and heart damage in order to improve diagnostic and therapeutic management of hepato‐cardio metabolic syndrome in children OSPEDALE BAMBINO GESU' Nobili Valerio Biomedica Digestive, Kidney and Urological Systems Hepatobiliary Pathophysiology ‐ HBPP RF‐2013‐ 02357896 Association between severe psoriasis and subclinical atherosclerotic vascular damage ISTITUTO DERMOPATICO DELL'IMMACOLATA Melillo Guido Biomedica Cardiovascular and Respiratory Sciences Clinical and Integrative Cardiovascular Sciences ‐ CICS RF‐2013‐ 02357898 Puglia PREDICTING FALLS AT HOME USING AN INTEGRATED ECG‐EMG‐EEG‐PAIN SENSORS (EEEPs) DETECTION SYSTEM‐NOT‐FALL‐ DE TOMMASO MARINA Biomedica Emerging Technologies and Neurotechnology ‐ Training in Neurosciences NT RF‐2013‐ 02357899 Un innovative way to improve cancer patient outcomes. Piemonte The effectiveness of a nurse‐led telephone follow‐up after therapeutic cancer treatment. A randomized controlled trial. Frigerio Simona Clinico‐ Healthcare Delivery and assistenzial Methodologies e Nursing Science: Adults and Older Adults ‐ NSAA RF‐2013‐ 02357909 Prevention of colorectal cancer with low‐dose aspirin and Liguria metformin in high risk subjects. De Censi Andrea Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Chemo/Dietary Prevention ‐ CDP Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Pagina 280 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02357917 Impact of short term fasting cycles on the efficacy of chemotherapy to treat pancreatic cancer CASA SOLLIEVO SOFFERENZA Andriulli Angelo Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP RF‐2013‐ 02357918 New therapies for glioblastoma IRCCS AOU San Martino‐ IST (Genova) Frosina Guido Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT RF‐2013‐ 02357920 SAN DONATO Modulation of glycosphingolipid metabolism for enhancing cell resistance to hypoxic stress: a new possible therapeutic approach for ischemic cardiovascular diseases Menicanti Lorenzo Biomedica Cardiovascular and Respiratory Sciences Myocardial Ischemia and Metabolism ‐ MIM RF‐2013‐ 02357926 New radiolabeled theranostic agents targeting molecular pathways responsible for metastatic spread Aloj Luigi Biomedica Oncology 1 ‐ Basic Translational Tumor Progression and Metastasis ‐ TPM2 RF‐2013‐ 02357929 Early Online Rehabilitation of Developmental Dyslexia: a BURLO GAROFALO randomized clinical study Lonciari Isabella Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Developmental Brain Disorders ‐ DBD RF‐2013‐ 02357930 Remote‐controlled monitoring and clinical clustering of gait and posture disorders in Parkinson Disease: an overlapping model inset between individual falls remitting and social relapsing. Lazio Pierantozzi Mariangela Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02357932 Antimicrobial stewardship and development of new laboratory procedures to assess biofilm production and drug resistance for nosocomial surveillance and prevention of healthcare associated infections SAN GALLICANO PRIGNANO GRAZIA Biomedica Infectious Diseases and Microbiology Clinical Research and Field Studies of Infectious Diseases ‐ CRFS RF‐2013‐ 02357933 Induced Pluripotent Stem Cells from schizophrenic patients as platforms for disease modeling and for understanding the molecular and cellular basis of refractoriness to clozapine treatments. Lombardia Scarone Silvio Biomedica Brain Disorders and Clinical Neuroscience Neural Basis of Psychopathology, Addictions and Sleep Disorders ‐ NPAS RF‐2013‐ 02357938 A prospective randomized phase II‐III study of continuous versus intermittent Dabrafenib and Trametinib therapy in BRAFV600 mutated metastatic melanoma patients: clinical efficacy and translational relevance Lombardia Mandala Mario Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e PASCALE Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Clinical Oncology ‐ CONC Pagina 281 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02357944 Tailored chemotherapy based on biomarkers expression in malignant pleural mesothelioma IRCCS AOU San Martino‐ IST (Genova) Grossi Francesco Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC RF‐2013‐ 02357946 Small Intestinal Bacterial Overgrowth (SIBO) syndrome in Multiple Sclerosis (MS) patients and stroke survivors. Umbria COREA FRANCESCO Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Brain Injury and Neurovascular Pathologies ‐ BINP RF‐2013‐ 02357947 Cancer Rehabiltation: definition of a multidimensional and multidisciplinary approach. Patient empowerment and Cost‐analysis. REGINA ELENA Pace Andrea Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02357949 Molecular characterization of lobular carcinoma of the breast and its variants. Emilia‐Romagna FOSCHINI MARIA PIA Clinico‐ Oncology 1 ‐ Basic assistenzial Translational e Cancer Molecular Pathobiology ‐ CAMP RF‐2013‐ 02357951 A study of the molecular and cellular mechanisms induced by macroenvironment (enriched environment) on tumor microenvironment of experimental mouse glioma NEUROMED Limatola Cristina Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME RF‐2013‐ 02357956 Combining immunomodulatory drugs with standard chemotherapy to revert tumor‐promoting Th2 inflammation in pancreatic cancer SAN RAFFAELE MILANO Protti Maria Pia Biomedica Immunology Transplantation, Tolerance and Tumor Immunology ‐ TTT RF‐2013‐ 02357958 Prevalence of infections in pregnancy among immigrant compared to resident mothers: effect of the inappropriateness of prenatal care on the incidence, severity and long term outcomes of congenital infections in each group's babies. OSPEDALE BAMBINO GESU' Auriti Cinzia Clinico‐ Infectious Diseases and assistenzial Microbiology e Infectious Diseases and Microbiology Fellowship ‐ F13 RF‐2013‐ 02357963 Unraveling the molecular basis of eicosapentaenoic acid (EPA) effects on neural development and neurodegeneration Istituto Superiore di Sanita' VITELLI LUIGI Biomedica Cellular and Molecular Biology of Neurodegeneration ‐ CMND Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Molecular, Cellular, and Developmental Neuroscience Classificazione 2° liv. Pagina 282 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02357966 Idiopathic Parkinson Disease diagnosis and pathogenesis: Istituto Scienze the search for reliable biomarkers Neurologiche Donadio Vincenzo Angelo Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02357969 INHIBITION OF DRUGGABLE GENE ABERRATIONS IN Emilia‐Romagna ER‐POSITIVE OR TRIPLE NEGATIVE OPERABLE BREAST CANCER. A WINDOW OF OPPORTUNITY TRIAL Frassoldati Antonio Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC RF‐2013‐ 02357971 Inhibition of dyskerin as a new approach to target ribosome biogenesis and cancer cell growth Montanaro Lorenzo Biomedica Oncology 2 ‐ Translational Clinical Drug Discovery and Molecular Pharmacology ‐ DMP RF‐2013‐ 02357977 GASLINI PHARMACOLOGICAL ACTIVATORS OF TMEM16A AND SLC26A9 CHLORIDE CHANNELS TO POTENTIATE MUCOCILIARY CLEARANCE AND INNATE DEFENSE MECHANISMS IN HUMAN AIRWAY DISEASES Galietta Luis Juan V Biomedica Cell Biology Membrane Biology and Protein Processing ‐ MBPP RF‐2013‐ 02357982 Molecular characterization of pulmonary sarcomatoid carcinoma, a deadly subtype of lung cancer, for patient management Pelosi Giuseppe Clinico‐ Genes, Genomes and assistenzial Genetics e RF‐2013‐ 02357985 Cost analysis of management of elderly sub‐acute stroke SAN RAFFAELE PISANA patients in Italy; healthcare costs reduction and quality life benefits on stroke patients using a ICT program of the tertiary prevention of cognitive decline and motor function through cognitive fun DEL PERCIO CLAUDIO Clinico‐ Emerging Technologies and Clinical assistenzial Training in Neurosciences Neurophysiology, e Devices, Auditory Devices and Neuroprosthesis Small Business ‐SBNE RF‐2013‐ 02357996 Cancer survivorship: extension of the italian medical‐ psychosocial paradigm to persons with active disease under therapeutical control. C.R.O. AVIANO Tirelli Umberto Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC RF‐2013‐ 02358001 Validation of novel assays to determine HIV neutralization and to measure the virus reservoir, key biomarkers of therapeutic efficacy and clinical outcome, for use in the clinical practice SAN GALLICANO Ensoli Fabrizio Biomedica AIDS Immunology and Pathogenesis ‐ AIP Emilia‐Romagna ISTITUTO TUMORI MILANO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. AIDS and Related Research Molecular Genetics ‐ MGA Pagina 283 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358010 Neuropeptide Y as regulator of macrophage phenotype and functions: a neuroimmune cue in atherosclerosis regression? RF‐2013‐ 02358011 Biomarkers of response to treatment in myasthenia gravis CARLO BESTA RF‐2013‐ 02358013 Toscana Tissue proteomics and SILAC‐based quantitative proteomic analysis of secretome of benign and malignant parathyroid tumors: identification of molecular and biochemical biomarkers for early diagnosis of parathyroid cancer. RF‐2013‐ 02358016 MicroRNAs in exhaled breath condensate and plasma: novel non invasive biomarkers for nonsmall cell lung cancer diagnosis. RF‐2013‐ 02358024 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Brigitta Biomedica Antozzi Carlo Clinico‐ Immunology assistenzial e Hypersensitivity, Autoimmune, and Immune Cetani Filomena Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS MAGGIORE Pesatori Angela Cecilia Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP NETosis in atherothrombotic disorders Veneto Pauletto Paolo Biomedica Vascular and Hematology Atherosclerosis and Inflammation of the Cardiovascular System ‐ AICS RF‐2013‐ 02358027 Development of diagnostic tools for foodborne viruses detection in outbreak settings: rapid screening methods and high‐throughput sequencing for a comprehensive response IZSLER Losio Marina Nadia Biomedica Veterinary Food Safety ‐ FOSA RF‐2013‐ 02358028 Epigenetics Meets Metabolomics: A Novel Diagnostic and Campania Therapeutic Approach in Heart Failure Perrino Cinzia Biomedica Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF RF‐2013‐ 02358029 Emilia‐Romagna Validation of a novel non‐invasive technique based on real time ultrasound B‐mode to assess the jugular venous pulse Zamboni Paolo Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Istituto Superiore di Sanita' Buttari Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Immunology Innate Immunity And Inflammation ‐ III Medical Imaging ‐ MEDI Pagina 284 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358030 MAUGERI COULD AN HOME BASED LONG TERM TELEMEDICINE PROGRAMME BE FEASIBLE AND REDUCE CARDIOVASCULAR RISK IN PATIENTS WITH METABOLIC SYNDROME? Scalvini Simonetta Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02358033 Functional interplay between metabotropic glutamate and nicotinic receptors in the modulation of plastic changes of striatal dopamine release: implications for Parkinson's Disease. Mercuri Nicola Biagio Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroplasticity and Neurotransmitters ‐ CNNT RF‐2013‐ 02358034 HIV‐1 regulatory protein Nef can contribute to increasing Istituto Superiore di Sanita' Eleonora susceptibility to malaria and opportunistic infections in primary human macrophage through modulation of class B scavenger receptor CD36 expression. Olivetta Biomedica AIDS and Related Research AIDS‐Associated Opportunistic Infections and Cancer ‐ AOIC RF‐2013‐ 02358037 Ergot alkaloids in cereals: occurrence, effect of processing Istituto Superiore di Sanita' De Santis and exposure assessment of the Italian consumer Barbara Biomedica Risk, Prevention and Health Behavior SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan ‐ TPM1 RF‐2013‐ 02358040 Angiogenesis impairment in diabetes: role of Nucleophosmin‐HMGB1 interaction Anna Biomedica Cell Biology Cellular Signaling and Regulatory Systems ‐ CSRS RF‐2013‐ 02358043 Nitrosation of pharmaceuticals of clinical use in humans: Istituto Superiore di Sanita' Pietraforte mechanism of transformation in human saliva at the acidic pH of the stomach, and evaluation of the associated potential genotoxic and carcinogenic risk. Donatella Biomedica Oncology 1 ‐ Basic Translational Cancer Etiology ‐ CE RF‐2013‐ 02358046 Develompment of an innovative 3D dynamic culture model in Bioreactor to be used as a surrogate Multiple Myeloma microenvironment for the investigation of tumor biology and the assessement of patient‐specific response to drugs SAN RAFFAELE MILANO Ferrero Elisabetta Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME RF‐2013‐ 02358047 Assessment of the diagnostic value of novel proteomic biomarkers within salivary microvescicles for the early non‐invasive diagnosis of primary Sjögren¿s syndrome Toscana Baldini Chiara Biomedica Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ‐ ACTS SANTA LUCIA ISTITUTO DERMOPATICO DELL'IMMACOLATA Di Carlo Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 285 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358052 Prevalence and burden of chronic hepatitis C virus infection in Italy: a representative nationwidestudy in the general population. Istituto Superiore di Sanita' Spada Enea Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS RF‐2013‐ 02358055 A longitudinal study on muscle synergies during walking in sub‐acute stroke persons: role of recovery and rehabilitation DON GNOCCHI Ferrarin Maurizio Biomedica Musculoskeletal, Oral and Skin Sciences Musculoskeletal Rehabilitation Sciences ‐ MRS RF‐2013‐ 02358056 Osteopontin and ICOS/B7h signaling pathways as possible targets for novel therapeutic strategies in psoriasis GALEAZZI Altomare Gianfranco Biomedica Immunology Hypersensitivity, Autoimmune, and Immune RF‐2013‐ 02358060 Primate to human cross‐species transmission of simian Type D retrovirus (SRV): seroprevalence study in Italian cohorts. Istituto Superiore di Sanita' Maggiorella Maria Teresa Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS RF‐2013‐ 02358061 An approach based on AZP531, the unacylated ghrelin (UnAG) analogue, to improve blood flow and support skeletal muscle regeneration in diabetes and peripheral artery disease (PAD). Piemonte Dentelli Patrizia Biomedica Atherosclerosis and Inflammation of the Cardiovascular System ‐ AICS RF‐2013‐ 02358066 Identification of biological features accounting for peripheral T‐cell lymphomas pathogenesis and refractoriness to Romidepsin in association with anthracycline‐based combination chemotherapy ISTITUTO TUMORI MILANO Corradini Paolo Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC RF‐2013‐ 02358069 Neoadjuvant peptide receptor radionuclide therapy (PRRT) with 90Y‐DOTATOC in pancreatic neuroendocrine tumors. I.E.O. Bodei Lisa Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Radiation Therapeutics and Biology ‐ RTB RF‐2013‐ 02358071 Infantile mitochondrial leukoencephalopathies: characterization of new phenotypes and identification of novel disease genes CARLO BESTA Moroni Isabella Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD RF‐2013‐ 02358072 MicroRNA regulation in the pathogenesis of MD and in the mechanism of action ofantidepressant drugs FATEBENEFRATELLI Bocchio‐ Chiavetto Luisella Biomedica Genes, Genomes and Genetics Molecular Genetics ‐ MGA Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Vascular and Hematology Pagina 286 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358076 New Healthcare Nano/Micromaterials for Paint and Floors Coatings Istituto Superiore di Sanita' Stringaro Annarita Biomedica Bioengineering Sciences and Technologies Nanotechnology ‐ NANO RF‐2013‐ 02358079 Study of new biomarkers for diagnoses of disorders of bile acid synthesis by mass spectrometry and metabolomics approach. Veneto GIORDANO GIUSEPPE Biomedica Digestive, Kidney and Urological Systems Hepatobiliary Pathophysiology ‐ HBPP RF‐2013‐ 02358080 A new insight into the role of ageing in smoking‐related diseases: a study of cell senescence and inflammation in Chronic Obstructive Pulmonary Disease (COPD) and Idiopathic Pulmonary Fibrosis (IPF) Veneto Saetta Marina Biomedica Cardiovascular and Respiratory Sciences Lung Cellular, Molecular, And Immunobiology ‐ LCMI RF‐2013‐ 02358082 Effects of Tumor‐associated Fibroblasts and tumor cells on the availability of efficient NK cells within the tumor core: characterization of molecular targets for therapy in melanoma and colon cancer IRCCS AOU San Martino‐ IST (Genova) Vitale Massimo Biomedica Immunology Transplantation, Tolerance and Tumor Immunology ‐ TTT RF‐2013‐ 02358083 Identification of novel biomarkers predictive of response to mitotane in patients with adrenocortical carcinoma to implement a personalized adjuvant treatment. Piemonte Terzolo Massimo Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02358084 Melanoma progression: identification of new epigenetic, druggable candidates of tumor growth in vivo. I.E.O. LANFRANCO LUISA MARIA NE Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC RF‐2013‐ 02358095 CareToy: a smart System for early home‐based intervention in infants at high risk for Cerebral Palsy STELLA MARIS Cioni Giovanni Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Developmental Brain Disorders ‐ DBD RF‐2013‐ 02358100 Neurogen origin of hypertension in hemodialytic patient: Lazio morphometric study of renal sympathetic innervation, its pathogenetic role and efficacy of renal bilateral denervation. MAURIELLO ALESSANDRO Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR RF‐2013‐ 02358101 Evaluation of bis‐maltolates, a novel class of maltol‐ derived compounds, as novel therapeutic tool for the treatment of high‐risk myelodysplastic syndrome (MDS) as single agents or in combination with DNA demethylating drugs. Leoni Pietro Biomedica Drug Discovery and Molecular Pharmacology ‐ DMP Marche Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Oncology 2 ‐ Translational Clinical Pagina 287 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358103 New methodologies for oncologic diagnostic in thyroid cancer Toscana RF‐2013‐ 02358105 USE OF LABELED MESENCHYMAL STEM CELLS AS DELIVERY VECTORS OF ANTI‐CANCER DRUGS RF‐2013‐ 02358109 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Paolo Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS Istituto Superiore di Sanita' Hassan Hamisa Jane Biomedica Oncology 2 ‐ Translational Clinical Developmental Therapeutics ‐ DT Cardiovascular risk and genetic hypercholesterolemias: improving risk assessment to optimize treatment Sicilia Averna Maurizio Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD RF‐2013‐ 02358114 For patients' sake: how research translates into practice. A study on the impact of publicly funded health research Emilia‐Romagna Addis Antonio Clinico‐ Healthcare Delivery and assistenzial Methodologies e Research on Ethical Issues in Human Studies ‐ REHS RF‐2013‐ 02358115 FOLLOW UP OF NEOPLASTIC CASES IN SENTINEL ANIMALS LIVING IN THE TERRITORY SO CALLED ¿TERRA DEI FUOCHI¿ IN CAMPANIA REGION IZSME degli Uberti Barbara Biomedica Oncology 1 ‐ Basic Translational Cancer Etiology ‐ CE RF‐2013‐ 02358117 Rehabilitation for bedridden patients: increasing performance and appropriateness by means of cognitive and autonomic data analysis Istituto Superiore di Sanita' D'Avenio Giuseppe Biomedica Integrative, Functional, and Cognitive Neuroscience Sensorimotor Integration ‐ SMI RF‐2013‐ 02358120 Pre‐clinical development of radiolabelled nanoparticles for molecular imaging of angiogenesis Toscana Pupi Alberto Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Clinical Molecular Imaging and Probe Development ‐ CMIP RF‐2013‐ 02358123 Targeting protein acetylation for non‐small cell lung REGINA ELENA cancer therapy: opportunities to overcome drug resistance Trisciuoglio Daniela Biomedica Oncology 2 ‐ Translational Clinical Drug Discovery and Molecular Pharmacology ‐ DMP RF‐2013‐ 02358126 A packaging siRNA nanotherapeutic approach addressing Associazione Oasi Maria SS Marchetti a causal defect of dopaminergic neurons to arrest nigrostriatal degeneration in experimental Parkinson's disease Bianca Maria Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02358142 An integrated model of multidisciplinary tools to target the practice of personalized medicine in rheumatoid arthritis Carlo Clinico‐ Musculoskeletal, Oral and assistenzial Skin Sciences e Emilia‐Romagna Vitti Salvarani Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Arthritis, Connective Tissue and Skin ‐ ACTS Pagina 288 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358147 Modulating seizure expression and brain damage with conventional and innovative therapeutic strategies in a rat model of human cortical dysplasia CARLO BESTA Colciaghi Francesca Biomedica Brain Disorders and Clinical Neuroscience Acute Neural Injury and Epilepsy ‐ ANIE RF‐2013‐ 02358150 Regulation and role of CCAR2 in DNA damage response and breast cancer progression ISTITUTO TUMORI MILANO Delia Domenico Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB RF‐2013‐ 02358152 Decreasing neuronal cell loss in Parkinsonisms by identifying stem cell mediated reparative mechanisms: a pilot study in Progressive Supranuclear Palsy. MAGGIORE Giordano Rosaria Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroplasticity and Neurotransmitters ‐ CNNT RF‐2013‐ 02358153 Cardio‐respiratory effects in relation to e‐cigarette use: building a clinical and epidemiological nation‐wide knowledge base Sicilia Polosa Riccardo Clinico‐ Risk, Prevention and assistenzial Health Behavior e Risk, Prevention and Intervention for Addictions ‐ RPIA RF‐2013‐ 02358154 Oleic acid counteracts cathepsin B‐related aggressiveness Istituto Superiore di Sanita' Mattia of metastatic melanoma Gianfranco Biomedica Oncology 1 ‐ Basic Translational Tumor Progression and Metastasis ‐ TPM2 RF‐2013‐ 02358155 Long‐term vs short‐term survivors patients with Malignant Pleural Mesothelioma: molecular markers, secretome and exome analysis Toscana CRISTAUDO ALFONSO Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02358156 IODINE NUTRITIONAL STATUS IN NEWBORNS AND CHILDREN 1‐5 YEARS OLD: A STRATEGY TO REDUCE IODINE DEFICIENCY IN HIGH RISK CATEGORIES OF THE POPULATION GASLINI GASTALDI ROBERTO Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Integrative Nutrition and Metabolic Processes ‐ INMP RF‐2013‐ 02358160 Creation and implementation of an integrated network for the management of diabetic foot Sicilia TRAPANI VINCENZO PIO Clinico‐ RF‐2013‐ 02358162 Immunologic biomarkers for clinical and therapeutic management of Autoimmune diseases SAN GALLICANO TRENTO ELISABETTA Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO Biomedica Hypersensitivity, Autoimmune, and Immune Immunology Pagina 289 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358163 Choline metabolism assessed by Fluorocholine Positron Emission Tomography for monitoring the response to trastuzumab in advanced breast cancer I. O. V. Cervino RF‐2013‐ 02358165 Axillary Reverse Mapping (ARM).Try to identify and spare lymphatic pathways in breast cancer surgery to prevent breast cancer related lymphedema (BCRL) Emilia‐Romagna RF‐2013‐ 02358168 How a multi‐organ (Heart, Thyroid, Kidneys) multi‐ marker strategy may improve risk prediction in children undergoing cardiac surgery: a model to prove that biomarkers in pediatric cardiac surgery are not mysterious but useful tools. RF‐2013‐ 02358170 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Basic Mechanisms of Cancer Therapeutics ‐ BMCT CARCOFORO PAOLO Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Surgery, Anesthesiology, and Trauma ‐ SAT Toscana Simona Storti Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS Enriching young people with Intellectual Disability Disorder: personalized telerehabilitation programs versus ordinary care. STELLA MARIS bargagna stefania Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Developmental Brain Disorders ‐ DBD RF‐2013‐ 02358171 Interferon regulatory factor 4 (IRF4) in chronic lymphocytic leukemia: functional, prognostic and therapeutic implications Emilia‐Romagna MARASCA ROBERTO Biomedica Cancer Molecular Pathobiology ‐ CAMP RF‐2013‐ 02358173 DEVELOPMENT AND IMPLEMENTATION OF NEW SANTA LUCIA TOOLS FOR THE VERIFICATION AND CONTROL OF THE EFFECTIVENESS OF INTERVENTIONS IN PERSON WITH SPINAL CORD INJURY Scivoletto Giorgio Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Acute Neural Injury and Epilepsy ‐ ANIE RF‐2013‐ 02358175 Study of the interactions between lentiviruses and transposable elements Barbara Biomedica AIDS and Related Research AIDS Molecular and Cellular Biology ‐ AMCB RF‐2013‐ 02358184 ROLE OF THE ACVR1 GENE AND THE BMP PATHWAY GASLINI IN PEDIATRIC ASTROCYTIC TUMORS Ravazzolo Roberto Biomedica Oncology 1 ‐ Basic Translational Cancer Genetics ‐ CG RF‐2013‐ 02358186 Clinical, diagnostic, pharmacological and pharmacogenetic management of Gambling disorder in Calabria, Italy. A prospective study. gallelli luca Clinico‐ Risk, Prevention and assistenzial Health Behavior e Istituto Superiore di Sanita' Ridolfi Calabria Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Anna Rita Oncology 1 ‐ Basic Translational Risk, Prevention and Intervention for Addictions ‐ RPIA Pagina 290 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358187 IS THERE A SYNERGYSM BETWEEN HEAD PAIN AND PELVIC PAIN IN WOMEN? THE CASE OF MIGRAINE AND ENDOMETRIOSIS ‐ A CLINICAL, NEUROPHYSIOLOGIC AND PHARMACOGENOMIC STUDY. RF‐2013‐ 02358189 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Rossella Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN Istituto Superiore di Sanita' scavia Pathogenesis of Shiga toxin‐producing Escherichia coli infections: study of the kinetics of Shiga toxins in the blood of infected patients with bloody diarrhea (hemorrhagic colitis) and/or hemolytic uremic syndrome, aimed at better understanding the mode gaia sofia giuseppina maria Biomedica Infectious Diseases and Microbiology Host Interactions with Bacterial Pathogens ‐ HIBP RF‐2013‐ 02358190 SAN GALLICANO Lipidomics and proteomics of the skin permeability barrier versus blood lipidome/sphingolipidome towards the identification of novel candidates involved in the barrier disruption and the design of innovative diagnostic tools and treatments in atopic derma CAMERA EMANUELA Clinico‐ Musculoskeletal, Oral and assistenzial Skin Sciences e Arthritis, Connective Tissue and Skin ‐ ACTS RF‐2013‐ 02358193 Lombardia The implementation of a new strategy to tailor mammography screening population to different patterns of breast cancer risk. Frammartino Brunella Clinico‐ Population Sciences and assistenzial Epidemiology e Epidemiology of Cancer ‐ EPIC RF‐2013‐ 02358197 Fighting drug resistance in triple negative breast cancer (TNBC): a combinatorial approach based on anti‐Kit ligand vaccination Piemonte Brizzi Maria Felice Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT RF‐2013‐ 02358206 Epigenetic and molecular mechanisms involved in the onset/progression of vulvar lichen sclerosus and vulvar squamous cell carcinoma. Emilia‐Romagna Martini Fernanda Biomedica Oncology 1 ‐ Basic Translational Molecular Oncogenesis ‐ MONC RF‐2013‐ 02358217 SYSTEMIC AND MUCOSAL CORRELATES OF PROTECTION IN HIV‐EXPOSED SERONEGATIVE INDIVIDUALS (HESN) Lombardia Gori Andrea Biomedica AIDS and Related Research AIDS Immunology and Pathogenesis ‐ AIP RF‐2013‐ 02358218 Identification of novel molecular mechanisms and AUXOLOGICO implementation of new diagnostic tools for growth disorders, investigated by using high throughput genome approaches Finelli Palma Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD SAN MATTEO Nappi Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 291 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO RF‐2013‐ 02358221 Ultrasound on bioeffects and safety: an integrated approach in evaluating ultrasound‐mediatedcell alterations at both cell membrane and genetic level RF‐2013‐ 02358224 DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Bedini Angelico Biomedica Cell Biology Membrane Biology and Protein Processing ‐ MBPP IZSLER Cheeses produced from raw milk: effect of heat treated milk on safety, characteristic organoleptic and nutritional properties Daminelli Paolo Biomedica Veterinary Food Safety ‐ FOSA RF‐2013‐ 02358230 Genome‐wide Association study to evaluate genetic risk factors for SPlanchnic‐venousthrombosis (GASP Study) MAGGIORE Bucciarelli Paolo Biomedica Vascular and Hematology Hemostasis and Thrombosis ‐ HT RF‐2013‐ 02358236 Ingestible capsule for photodynamic treatment of Helicobacter pylori infection Toscana Orsini Barbara Biomedica Infectious Diseases and Microbiology Drug Discovery and Mechanisms of Antimicrobial Resistance ‐ DDR RF‐2013‐ 02358237 Compliance to clinical guidelines for epithelial ovarian cancer in relation to patient outcome. A population‐ based clinical audit in the Piedmont Regional Cancer Network Piemonte Zola Paolo Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02358244 SAFETY AND EFFICACY OF PHYTOSOMIAL CURCUMIN IN NON‐ALCOHOLIC FATTY LIVER DISEASE: A DOUBLE‐BLIND, RANDOMIZED, PLACEBO‐CONTROLLED TRIAL. Piemonte GAMBINO Roberto Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Integrative Nutrition and Metabolic Processes ‐ INMP RF‐2013‐ 02358245 Gene networks controlling motor neuron degeneration in MARIO NEGRI spinal muscular atrophy for the development of new therapeutic strategies: a comparative transcriptomic approach based on induced pluripotent stem cells and mouse models GARATTINI ENRICO Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND RF‐2013‐ 02358246 Role of heavy metals in the onset and progression of human gastrointestinal inflammation Cuomo Rosario Biomedica Digestive, Kidney and Urological Systems Gastrointestinal Mucosal Pathobiology ‐ GMPB INAIL Campania Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 292 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358248 Immunological eradication of minimal residual disease in Piemonte multiple myeloma by checkpoint blockade and unleashing anti‐tumor immune responses RF‐2013‐ 02358256 EMERGING ONCOGENIC PAPILLOMAVIRUS AND POLYOMAVIRUS IN WATER ENVIRONMENTS: A COMPREHENSIVE APPROACH TO ASSESS THE POTENTIAL FOR WATERBORNE TRANSMISSION RF‐2013‐ 02358257 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Massimo Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII Istituto Superiore di Sanita' La Rosa Giuseppina Biomedica Infectious Diseases and Microbiology Infectious Diseases and Microbiology Fellowship ‐ F13 Radiation Induced abscopal/Bystander Effects (RIBEs) upon Stereotactic Body RadioTherapy (SBRT) in oligometastatic patients: identification of the molecular/cellular players involved REGINA ELENA Bossi Gianluca Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Oncology 2 ‐ Translational Clinical Small Business [SBIR/STTR] Radiation Therapy and Biology ‐SETA] RF‐2013‐ 02358258 Klebsiella pneumoniae carbapenemases (KPCs) positive strains in hospitalized patients non responders to antibiotic therapy and without any other therapeutic option: evaluation of a rescue therapy based on faecal‐ microbiota transplantation (FMT). SAN MATTEO BRUNO RAFFAELE Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS RF‐2013‐ 02358261 Phase II trial of carfilzomib and lenalidomide‐based treatment for transplant eligible and non‐eligible newly diagnosed patients with primary plasma cell leukemia: a total‐therapy model with focus on prognostic role of genomic signature. CROB Musto Pellegrino Biomedica Oncology 2 ‐ Translational Clinical Clinical Oncology ‐ CONC RF‐2013‐ 02358263 OLEUROPEIN FOR TREATMENT OF ULCERATIVE COLITIS: FROM BENCH SIDE TO CLINICS. Calabria Luzza Francesco Biomedica Digestive, Kidney and Urological Systems Clinical, Integrative and Molecular Gastroenterology ‐ CIMG RF‐2013‐ 02358264 MicroRNAs as plasma biomarkers of carotid plaque instability Veneto Scuro Alberto Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD Massaia Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 293 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358265 Gene expression profile of peripheral nerves in patients with Amyotrophic Lateral Sclerosis. SAN RAFFAELE MILANO Quattrini Angelo Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02358266 Human adipose ‐ mesenchymal stem cells trasplantation in degenerative disc disease: in vitro and invivo study of the molecular mechanism involved in immunomodulation and cell recovery. CARLO BESTA Ferri Anna Lucia Maria Biomedica Bioengineering Sciences and Technologies Gene and Drug Delivery Systems ‐ GDD RF‐2013‐ 02358273 Pseudoviral Immunity and Podocyte stress proteins in Lupus Erithematosus. From 'in vivo' research on auto‐ antibodies to mechanisms GASLINI Bruschi Maurizio Biomedica Digestive, Kidney and Urological Systems Pathobiology of Kidney Disease ‐ PBKD RF‐2013‐ 02358274 Molecular targeting of Notch signaling as a novel therapeutic strategy for multiple myeloma treatment MAGGIORE Neri Antonino Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP RF‐2013‐ 02358276 Development of a model for quantitative risk assessment of tick‐borne diseases in Italian city parks Istituto Superiore di Sanita' Vescio Maria Fenicia Biomedica Population Sciences and Epidemiology Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions ‐ IRAP RF‐2013‐ 02358283 Metabolomic profile of abdominal adipose tissue as a tool AUXOLOGICO to identify the effect of endocrine disruptors in human obesity: a potential clue for diagnostic and therapeutic approach. Marzullo Paolo Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular Aspects of Diabetes and Obesity ‐ CADO RF‐2013‐ 02358297 Myo‐inositol in the prevention of gestational diabetes in women at high risk. A multicentric, randomized, double‐ blind, placebo controlled study. Sicilia D'Anna Rosario Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Pregnancy and Neonatology ‐ PN RF‐2013‐ 02358301 GERIATRIC ASSESSMENT IN THE ONCOLOGY SETTING: VALIDATION OF A MULTIDIMENSIONAL PROGNOSTIC INDEX Emilia‐Romagna INDELLI MONICA Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 294 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358304 Safety, immunogenicity and efficacy of vaccinations against Influenza, Pneumococcus, Hepatitis B, Papillomavirus and Herpes Zoster in patients with autoimmune diseases under immunosuppressive treatment Lazio D'Amelio Raffaele Clinico‐ Immunology assistenzial e Vaccines Against Microbial Diseases ‐ VMD RF‐2013‐ 02358309 Radiation exposure optimization by wireless technology for professionals involved in the management and care of patients undergoing therapy with radionuclides. Implementation of environmental monitoring. CROB Storto Giovanni Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02358313 Development and implant of the photovoltaic artificial retina in the pig with photoreceptor degeneration: towards the human Phase‐1 experimentation Veneto Pertile Grazia Biomedica Biomaterials and Biointerfaces ‐ BMBI RF‐2013‐ 02358317 Piemonte RESPIRATORY‐GATED DEEP INSPIRATION BREATH HOLD AND SURFACE IMAGING FOR RADIOTHERAPY OF LEFT SIDED BREAST CANCER Krengli Marco Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Radiation Therapeutics and Biology ‐ RTB RF‐2013‐ 02358318 Enhancement of miR‐34a‐mediated neurogenesis as novel therapeutic approach for aging and neurodegeneration Istituto Superiore di Sanita' MERLO DANIELA Biomedica Cell Death in Neurodegeneration ‐ CDIN RF‐2013‐ 02358332 Prospective Appraisal of The Prevalence of Primary Aldosteronism in HYpertensive Patients Presenting with Lone Atrial Fibrillation (PAPPHY Study): Understanding The Mechanisms To Optimize The Diagnosis. Veneto Rossi Gian Paolo Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF RF‐2013‐ 02358333 The tumorigenic potential of cancer stem cells and the influence of inflammasome activation in the pathophysiology of cholangiocarcinoma. Marche Benedetti Antonio Biomedica Cancer Molecular Pathobiology ‐ CAMP RF‐2013‐ 02358335 Pulmonary infections by Pseudomonas aeruginosa in a third‐level paediatric university hospital: study of mechanisms involved in adaptation, virulence, transmission, development of antibiotic resistance Toscana CAMPANA SILVIA Clinico‐ Infectious Diseases and assistenzial Microbiology e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Bioengineering Sciences and Technologies Brain Disorders and Clinical Neuroscience Oncology 1 ‐ Basic Translational Clinical Research and Field Studies of Infectious Diseases ‐ CRFS Pagina 295 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358336 Angiogenic and anti‐angiogenic factors in children with Infantile Haemangioma: how they change under treatment with oral propranolol. Toscana de Martino Maurizio Biomedica Vascular and Hematology Vascular Cell and Molecular Biology ‐ VCMB RF‐2013‐ 02358338 New therapeutic options for newborns with retinopathy of prematurity Toscana Filippi Luca Biomedica Cell Biology Biology and Diseases of the Posterior Eye ‐ BDPE RF‐2013‐ 02358348 Transcranial direct current stimulation (tDCS) and speech therapy in Primary Progressive Aphasias (PPA) FATEBENEFRATELLI Cotelli Maria Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02358349 Telestroke plus home‐telemonitoring project. Feasibility, MONDINO reliability, impact on quality of care and health costs of a nodal telemedicine network for a non‐stop monitoring of stroke patients from the acute to the chronic phase of the disease. Cavallini Anna Maria Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02358350 The paradox of persistent 5 alpha reductase inhibition by Emilia‐Romagna finasteride: a model of neuropathy and a pharmacogenetic approach Simoni Manuela Biomedica Molecular and Cellular Endocrinology ‐ MCE RF‐2013‐ 02358351 EARLY‐START EXERCISE TRAINING AFTER ACUTE HEMODYNAMIC DECOMPENSATION IN PATIENTS WITH CHRONIC HEART FAILURE. A RANDOMIZED, CONTROLLED TRIAL ON FEASIBILITY AND SHORT‐ AND MEDIUM‐TERM IMPACT ON FUNCTIONAL CAPACITY, SYMPTOMS AND REHOSPITALIZATIONS. Mezzani Alessandro Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS RF‐2013‐ 02358352 IZSUM Food safety of bivalve molluscs: Development and application of molecular tools for identification, quantification and evaluation of antibiotic resistance and virulence potential of food‐associated enteric and autochthonous bacterial pathogens Leoni Francesca Biomedica Veterinary Food Safety ‐ FOSA RF‐2013‐ 02358355 Mutational analysis of Hedgehog signaling pathway genes Piemonte in basal cell carcinomas from tacrolimus/cyclosporine‐ treated renal transplant recipients Boldorini Renzo Luciano Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS MAUGERI Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Endocrinology, Metabolism, Nutrition and Reproductive Sciences Pagina 296 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358356 MOLECULAR AND SEROLOGICAL SURVEY FOR EMERGING ENTERIC VIRUSES WITH ZOONOTIC POTENTIAL IN WILD ANIMALS IN ITALY IZSPLV ORUSA RICCARDO Biomedica RF‐2013‐ 02358361 DIAMOND (DIet, Activity and MONitoring): a personalized lifestyle intervention trial for breast cancer patients. I.E.O. Titta Lucilla Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Chemo/Dietary Prevention ‐ CDP RF‐2013‐ 02358362 Xenotransplantation of primary cancer samples in zebrafish embryos: towards personalised medicine Toscana Morelli Luca Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC RF‐2013‐ 02358365 Metallothioneins as predictive biomarkers for cardiovascular events in patients with severe carotid or peripheral atherosclerosis I.N.R.C.A. Giacconi Roberta Biomedica Vascular and Hematology Atherosclerosis and Inflammation of the Cardiovascular System ‐ AICS RF‐2013‐ 02358370 New technologies for a predictive, personalized, preventive and participatory (4P) medicine in atrial fibrillation Istituto Superiore di Sanita' Giovanni Calcagnini Biomedica Healthcare Delivery and Methodologies Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02358371 Development of an in vitro model system based on clonal MAGGIORE amniotic fluid stem cells for dissecting the epigenetic mechanisms underlying pathogenesis of Kabuki syndrome Lazzari Lorenza Biomedica Biology of Development and Aging Cellular Mechanisms in Aging and Development ‐ CMAD RF‐2013‐ 02358372 THE MEVALONATE PATHWAY AND CXCR4 Piemonte SIGNALING CROSS‐TALK IN CHRONIC LYMPHOCYTIC LEUKEMIA: A TARGET TO OVERCOME FLUDARABINE RESISTANCE? coscia marta Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME RF‐2013‐ 02358373 Early and late graft failure in liver transplantation: impact Emilia‐Romagna of pre formed and de novo specific antibodies, definition of histological damage and antibodies mediated failure and new immunosuppression strategy to prevent antibodies graft failure BONTADINI ANDREA Clinico‐ Immunology assistenzial e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Veterinary Animal Health ‐ ANHE Transplantation, Tolerance and Tumor Immunology ‐ TTT Pagina 297 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358374 Role of Mycobacterium avium subspecies paratuberculosis (Map) as a trigger in Type 1 Diabetes, Hashimoto Thyroiditis and Multiple Sclerosis Sardegna Sechi Leonardo Antonio Biomedica Infectious Diseases and Microbiology Host Interactions with Bacterial Pathogens ‐ HIBP RF‐2013‐ 02358376 CARDIOGEN DECODER: Interpretation of clinical, pathologic, imaging and genetic big data in a large population of genotyped heritable cardiomyopathies. SAN MATTEO ARBUSTINI ELOISA Biomedica Cardiovascular and Respiratory Sciences Clinical and Integrative Cardiovascular Sciences ‐ CICS RF‐2013‐ 02358384 Personalized molecular medicine in patients with defined GASLINI and undifferentiated autoinflammatory diseases: a rational approach. Gattorno Marco Clinico‐ Immunology assistenzial e Innate Immunity And Inflammation ‐ III RF‐2013‐ 02358385 SAN MATTEO Characterisation of basal and post‐absorptive Glucagon Like Peptides secretory profile in patients with Metabolic Syndrome and Inflammatory Bowel Disease Lucotti Pietro Carlo Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO RF‐2013‐ 02358388 Extracellular matrix (ECM): new strategies for diagnostic, Veneto therapeutic and clinical care in Oncology Agostini Marco Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02358389 Novel 2D and 3D human models of cardiorenal pathophysiology and drug discovery Veneto GEROSA GINO Biomedica Bioengineering Sciences and Technologies Modeling and Analysis of Biological Systems ‐ MABS RF‐2013‐ 02358390 DEVELOPMENT AND CLINICAL APPLICATION OF A NOVEL RADIOGUIDED SURGERY TECHNIQUE IN BRAIN TUMORS CARLO BESTA Ferroli Paolo Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Small Business Bioengineering, Surgical Sciences, and Technology ‐ SBTS (SBIR/STTR) RF‐2013‐ 02358397 Detection of vector‐borne viruses in Sardinia by metagenomics and evaluation of Bluetongue virus evolution IZSAM Savini Giovanni Biomedica Veterinary Animal Health ‐ ANHE RF‐2013‐ 02358398 Endocannabinoids and growth factors cross‐talk in the process of wound healing SAN GALLICANO Cardinali Giorgia Biomedica Cell Biology Molecular and Integrative Signal Transduction ‐ MIST Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 298 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358400 Genetic and epigenetic mechanisms in Cluster Headache: Emilia‐Romagna genomic and plasma exosome miRNA studies Pini Luigi Alberto Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02358401 TOWARDS A PRECISION MEDICINE APPROACH TO CHRONIC OBSTRUCTIVE PULMONARY DISEASE SAN MATTEO Luisetti Maurizio Biomedica Cardiovascular and Respiratory Sciences Respiratory Integrative Biology and Translational Research ‐ RIBT RF‐2013‐ 02358402 EPIDEMIOLOGICAL, CLINICAL AND MOLECULAR CHARACTERIZATION OF POST‐TRANSPLANT MALIGNANCIES: IMPLICATIONS FOR CANCER PREVENTION AND PROGNOSIS IN RECIPIENTS OF KIDNEY AND LIVER TRANSPLANTS C.R.O. AVIANO Serraino Diego Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02358403 Xeno‐free neural crest derived‐human stem cells from oral tissue as a new tool for the modeling and treatment of Multiple Sclerosis: towards personalized medicine in neuroinflammatory/neurodegenerative disorders. Abruzzo Lugaresi Alessandra Biomedica Molecular, Cellular, and Developmental Neuroscience Neurodifferentiation, Plasticity, and Regeneration ‐ NDPR RF‐2013‐ 02358406 Myofiber‐microenvironment interaction as a trigger and Lazio a therapeutic target for muscle wasting in cancer cachexia. MUSCARITOL MAURIZIO I Biomedica Musculoskeletal, Oral and Skin Sciences Skeletal Muscle Biology and Exercise Physiology ‐ SMEP RF‐2013‐ 02358408 Immune checkpoints blockade and epigenetic immunomodulation: a novel therapeutic approach in malignant mesothelioma Toscana Calabro' Luana Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII RF‐2013‐ 02358409 A novel structural and functional MRI‐derived index of axonal myelination: application to MS and correlation with neurophysiology SANTA LUCIA Cercignani Mara Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroimmunology and Brain Tumors ‐ CNBT RF‐2013‐ 02358413 C.R.O. AVIANO Improving Diagnostic and Therapeutic Pathway in Ovarian Cancer: taking advantage of a specialized referral center. SORIO ROBERTO Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 299 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE Classificazione 1 Liv. Classificazione 2° liv. RF‐2013‐ 02358416 Exome sequencing to identify new disease genes for Essential Tremor Sicilia Aridon Paolo Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD RF‐2013‐ 02358417 Markers and Biofilm‐Related Infection DiaGnostic Evolution [M BRIDGE]: development of a new platform for prosthetic and joint infections GALEAZZI Drago Lorenzo Biomedica Infectious Diseases and Microbiology Clinical Research and Field Studies of Infectious Diseases ‐ CRFS RF‐2013‐ 02358419 Personnel and workers with pacemaker or implantable defibrillator in the MRI environment: methods and experimental data collection for the risk assessment Istituto Superiore di Sanita' Triventi Michele Biomedica Healthcare Delivery and Methodologies Community‐Level Health Promotion ‐ CLHP RF‐2013‐ 02358423 Multilineage differentiation of limbal stem cells for regenerative medicine. Sicilia GIORDANO CARLA Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Molecular and Cellular Endocrinology ‐ MCE RF‐2013‐ 02358424 Capturing human amniotic mesenchymal stromal cell (hAMSC)‐derived key effectors that induce protection after traumatic brain injury MARIO NEGRI Roncati Zanier Elisa Biomedica Brain Disorders and Clinical Neuroscience Brain Injury and Neurovascular Pathologies ‐ BINP RF‐2013‐ 02358425 Dissecting the role of the B cell receptor‐regulated miR‐ 132/212 cluster in mediating anergy and apoptosis in normal and malignant B cells C.R.O. AVIANO Gattei Valter Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP RF‐2013‐ 02358429 Molecular profiling of myeloid neoplasms for developing innovative precision medicine strategies SAN MATTEO CAZZOLA MARIO Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02358434 Spatially variant prescription of dose radiation according to hypoxic tumor distribution assessed by hypoxia markers and biological imaging: a phases I‐II study in non small cell lung cancer. CROB Nappi Antonio Biomedica Oncology 2 ‐ Translational Clinical Oncology 2 ‐ Translational Clinical Small Business [SBIR/STTR] Radiation Therapy and Biology ‐SETA] RF‐2013‐ 02358435 Molecular understanding of E3 ligases involved in signaling and cancer I.E.O. Pasqualato Sebastiano Biomedica Biological Chemistry and Macromolecular Biophysics Macromolecular Structure and Function C ‐ MSFC Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Pagina 300 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358436 Role of exosomes on immune response inflammatory/regulatory balance during chronic HCV and HBV infections RF‐2013‐ 02358438 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Agrati Chiara Biomedica Immunology Immunity and Host Defense ‐ IHD DE BELLIS Alterations of gut barrier and lipid metabolism in subjects with liver steatosis: novel insights into molecular targets and interventions using prebiotics Notarnicola Maria Biomedica Risk, Prevention and Health Behavior SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan ‐ TPM1 RF‐2013‐ 02358445 Intestinal microbiota and chronic inflammatory disease in children Toscana Lionetti Paolo Biomedica Infectious Diseases and Microbiology Host Interactions with Bacterial Pathogens ‐ HIBP RF‐2013‐ 02358446 Assessment of the therapeutic value of targeting cancer stem cells in Numb‐deficient breast cancer. I.E.O. Tosoni Daniela Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB RF‐2013‐ 02358447 Evaluation of human exposure to Aedes mosquitoes: integration of molecular and immunological approaches for the development of novel tools to assess vector control strategies and estimate arboviral disease risk. Istituto Superiore di Sanita' DI LUCA MARCO Biomedica Infectious Diseases and Microbiology Vector Biology ‐ VB RF‐2013‐ 02358451 Puglia Varicella zoster infections in patients on immunosuppressant therapy: prognostic role and value of vaccine prevention RF‐2013‐ 02358452 The "Elderly Project" aimed at the prospective multidimensional assessment of elderly patients with Diffuse Large B‐Cell Lymphoma ARCISPEDALE RF‐2013‐ 02358456 Thyroid dysfunction and chemical compound exposure in the etiology of Attention‐Deficit/Hyperactivity Disorder (ADHD) RF‐2013‐ 02358458 A NUTRITIONAL APPROACH TO CANCER: A PILOT STUDY IN TWO AREAS OF CAMPANIA CHARACTERIZED BY DIFFERENT ENVIRONMENTAL RISK SPALLANZANI Germinario Cinzia Annatea Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS MERLI FRANCESCO Clinico‐ Biology of Development assistenzial and Aging e Aging Systems and Geriatrics ‐ ASG Istituto Superiore di Sanita' Panei Pietro Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Developmental Brain Disorders ‐ DBD Istituto Superiore di Sanita' Straface Elisabetta Biomedica Cancer Molecular Pathobiology ‐ CAMP Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Oncology 1 ‐ Basic Translational Pagina 301 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO RF‐2013‐ 02358461 Vitamin D and Microbiota in colorectal cancer RF‐2013‐ 02358464 DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Gandini Sara Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Chemo/Dietary Prevention ‐ CDP A model to assess the effect of tissue ozonisation as a new Friuli‐Venezia Giulia strategy to treat endometriosis Mariuzzi Laura Biomedica Integrative and Clinical Endocrinology and Reproduction ‐ ICER RF‐2013‐ 02358465 Pathophysiology of fatigue in Parkinson's disease and effect of aerobic rehabilitation STOCCHI FABRIZIO Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02358474 Failure of traditional risk factors in predicting subclinical SAN MATTEO atherosclerosis. Search for novel imaging‐based, biochemical and molecular markers in a clinically healthy population. DE SERVI STEFANO Biomedica Clinical and Integrative Cardiovascular Sciences ‐ CICS RF‐2013‐ 02358478 Study on microRNAs as early predictors of contrast‐ induced nephropathy in patients with acute myocardial infarction treated with percutaneous coronary intervention. Emilia‐Romagna Ansani Lucia Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Myocardial Ischemia and Metabolism ‐ MIM RF‐2013‐ 02358479 Angelman Syndrome: a clinical‐neurophysiological, functional imaging and biochemical investigation to uncover new therapeutic strategies MEDEA Bonanni Paolo Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD RF‐2013‐ 02358490 Piemonte IS CHOLESTERYL ESTER STORAGE DISEASE AN UNDER‐RECOGNIZED CAUSE OF ATHEROSCLEROSIS AND LIVER DYSFUNCTION? Guardamagna Ornella Biomedica Vascular and Hematology Atherosclerosis and Inflammation of the Cardiovascular System ‐ AICS RF‐2013‐ 02358491 Mesenchimal stromal cells for congenital and acquired skin lesions. Translational research in pediatric surgery Pelizzo Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences ‐ BTSS I.E.O. SAN RAFFAELE PISANA SAN MATTEO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Gloria Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cardiovascular and Respiratory Sciences Pagina 302 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358493 RAVER2‐mediated RNA processing disregulation in Autosomal Dominant Leukodystrophy Istituto Scienze Neurologiche Capellari Sabina Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND RF‐2013‐ 02358495 Circulating endothelial cells (CEC) and microRNA as novel biomarkers predicting the response to antiangiogenetic therapy in epithelial ovarian cancer C.R.O. AVIANO ROSSI FRANCESCA MARIA Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02358499 Target identification and relevance assessment of registered drugs with myelin repair potential Istituto Superiore di Sanita' Agresti Cristina Biomedica Brain Disorders and Clinical Neuroscience Brain Injury and Neurovascular Pathologies ‐ BINP RF‐2013‐ 02358501 Design of rational and innovative immunogens based on HIV‐1 clade C Env proteins specifically mutated in selected conserved glycans for broadly effective vaccine purpose Istituto Superiore di Sanita' Cenci Alessandra Biomedica AIDS and Related Research AIDS Immunology and Pathogenesis ‐ AIP RF‐2013‐ 02358502 ROLE OF THE DNAM‐1/PVR PATHWAY IN THE PATHOGENESIS OF HIV‐1 INFECTION OSPEDALE BAMBINO GESU' Doria Margherita Clinico‐ AIDS and Related Research assistenzial e AIDS Immunology and Pathogenesis ‐ AIP RF‐2013‐ 02358504 A novel integrated approach to the diagnosis and prognosis of Disorders of Consciousness Emilia‐Romagna PIPERNO ROBERTO Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Brain Injury and Neurovascular Pathologies ‐ BINP RF‐2013‐ 02358508 Persistent toxic pollutants (PTS) in Mediterranean seafood: Analysis of time trends and dietary exposure risk assessment [MedFoodRisk] Istituto Superiore di Sanita' Miniero Roberto Biomedica Food Safety ‐ FOSA RF‐2013‐ 02358513 Metastatic potential of CD44v6 + circulating tumor cells in gastrointestinal malignancies CROB Aieta Michele Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02358514 A dedicated informatics tool to assist both medical decision making and costs burden evaluation in surgery intervention for thyroid patients REGINA ELENA APPETECCHI MARIALUISA A Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Veterinary Pagina 303 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO RF‐2013‐ 02358519 Early atherosclerosis in patients with steatosis and with chronic hepatitis C: role of visceral adiposity, procoagulant imbalance and endothelial dysfunction in vascular damage MAGGIORE Fracanzani Anna Ludovica Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO RF‐2013‐ 02358520 Ex vivo stratification of sarcoma patients who could benefit of targeted adjuvant therapy PASCALE Fazioli Flavio Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Computational modeling and sciences for biomedical and clinical applications ‐ ZRCM RF‐2013‐ 02358522 Mitochondrial functional Index through Translational approach focused on Oxidative metabolism SAN GALLICANO Dell'Anna Maria Lucia Biomedica Cellular Signaling and Regulatory Systems ‐ CSRS RF‐2013‐ 02358529 OSPEDALE BAMBINO Daily monitoring of pediatric asthmatic outpatients: pollution and health relationship. Studies of the adoption GESU' and dissemination of health‐risk behavior preventive interventions and services or adherence to treatment and/or complementary treatments Cutrera Renato Clinico‐ Risk, Prevention and assistenzial Health Behavior e SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan ‐ TPM1 RF‐2013‐ 02358530 stem cells on structural fat grafting GALIE' MANLIO Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences ‐ BTSS RF‐2013‐ 02358533 Predictive biomarkers of response to PARP‐1 inhibition as Istituto Oncologico Candiolo therapeutic strategy to improve DNA damaging agents¿ efficacy in bone and soft tissue sarcomas Grignani Giovanni Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS paola Biomedica Infectious Diseases and Microbiology Infectious Diseases and Microbiology Fellowship ‐ F13 RF‐2013‐ 02358535 DESTINATARIO ISTITUZIONALE Emilia‐Romagna Istituto Superiore di Sanita' chiani EVALUATION OF THE THERAPEUTIC ACTIVITY OF UNIVERSAL, ANTI‐BETA‐GLUCAN ANTIBODIESAGAINST MAJOR HUMAN FUNGAL PATHOGENS Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Cell Biology Pagina 304 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358537 From genes to connectome: interactions between genetic, SANTA LUCIA environmental, cognitive and brain factors in patients with preclinical and clinical Alzheimer¿s Disease. Serra Laura Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02358540 BRAIN CONNECTIVITY IN EARLY POST‐SURGICAL MAUGERI PRIMARY BRAIN TUMOR PATIENTS: RELEVANCE FOR PREDICTING INTENSIVE EARLY POST‐SURGICAL REHABILITATION OUTCOME BASSO Gianpaolo Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02358542 MiRNA expression profile in Amyotrophic Lateral Sclerosis and interaction with biomarkers of clinical features Simone Isabella Laura Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02358545 A systematic use of computer support finalized to prevent Emilia‐Romagna the renal toxicity of drugs interaction and dosage. Bianchi Stefano Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02358551 Blood Management Program in cancer surgery Bonini Alessandro Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02358554 I.N.R.C.A. Identifying if recommended glucose targets are associated with an increased risk on negative outcomes in elderly frail patients with Type 2 Diabetes Abbatecola Angela Marie Clinico‐ Population Sciences and assistenzial Epidemiology e Kidney, Nutrition, Obesity and Diabetes ‐ KNOD RF‐2013‐ 02358555 miRNA signature of early neuroglial involvement in the retina of diabetic patients. BIETTI Varano Monica Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Molecular and Cellular Endocrinology ‐ MCE RF‐2013‐ 02358560 The Hereditary Diffuse Gastric Cancer syndrome: from susceptibility genes to clinical management I.E.O. BONANNI BERNARDO Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD RF‐2013‐ 02358561 The contribution of genetic and metabolic factors to drug MAGGIORE resistance in pediatric nephrotic syndrome. Turolo Stefano Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Puglia ARCISPEDALE Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pathobiology of Kidney Disease ‐ PBKD Pagina 305 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358562 MICROTISSUE PRODUCTION FROM HUMAN GLIOBLASTOMA STEM CELLS: A NEW PRECLINICAL MODEL TO INVESTIGATE NOVEL TARGETS FOR PRECISION TREATMENTS Istituto Scientifico Romagnolo Tesei Anna Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME RF‐2013‐ 02358569 Identification of imaging biomarkers for the biological characterisation of high grade cerebral tumours. HUMANITAS CHITI ARTURO Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Medical Imaging ‐ MEDI RF‐2013‐ 02358571 AN INTEGRATED WORKFLOW TO DISCOVER COMPOUNDS ABLE TO MODULATE THE BONE MORPHOGENETIC PROTEIN SIGNALING GASLINI Bocciardi Renata Biomedica Cell Biology Cellular Signaling and Regulatory Systems ‐ CSRS RF‐2013‐ 02358581 Induced pluripotent stem cells (iPS) as a new model for cardiac and skeletal muscle pathogenesis in myotonic dystrophy type 1 (DM1). DON GNOCCHI Santoro Massimo Biomedica Genes, Genomes and Genetics Therapeutic Approaches to Genetic Diseases ‐ TAG RF‐2013‐ 02358587 Comparison among different chronic disease models in Lombardia Lombardia Region and analysis and design of innovative strategies to improve quality of care and optimise resources' utilisation. Integration of the different models, with e health and telemedicine su VAGHI ADRIANO Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02358588 eNK, herpesvirus infection and HLA‐G molecules as prognostic markers for primary unexplained infertility. Emilia‐Romagna Marci Roberto Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cellular, Molecular and Integrative Reproduction ‐ CMIR RF‐2013‐ 02358593 Use of agricultural by‐products as feed supplement for prevention of Campylobacteriosis IZSME Garofalo Francesca Biomedica Veterinary Food Safety ‐ FOSA RF‐2013‐ 02358595 Emilia‐Romagna ASSESSING A NOVEL RNA‐BASED THERAPEUTIC APPROACH FOR DOMINANT NEGATIVE MUTATIONS IN COLLAGEN TYPE VI RELATED MUSCULAR DYSTROPHIES: TARGETING SINGLE‐NUCLEOTIDE POLYMORPHISMS TO PROMOTE OUT‐OF‐FRAME EXON SKIPPING AND ALLELE‐SPECIFIC GENE SILENCING. Gualandi Francesca Biomedica Genes, Genomes and Genetics Therapeutic Approaches to Genetic Diseases ‐ TAG Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 306 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358596 Omega 3‐based nutraceuticals as modulators of endocannabinoid signaling: a potential strategy for mechanistic understanding and management of Alzheimer's disease SANTA LUCIA Maccarrone Mauro Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02358603 RECONSTRUCTION OF HUMAN URETHRA WITH A REGENERATIVE MEDICINE PROCOL IN URETHRAL STRICTURE REPAIR Umbria Costantini Elisabetta Biomedica Digestive, Kidney and Urological Systems Renal and Urological Sciences Small Business Activities ‐ SERU RF‐2013‐ 02358605 REDOX REGULATION OF MUTYH DNA‐ GLYCOSYLASE ACTIVITY VIA ITS IRON SULFUR CLUSTER AND ROLE IN INFLAMMATION Istituto Superiore di Sanita' MAZZEI FILOMENA Biomedica Oncology 1 ‐ Basic Translational Cancer Etiology ‐ CE RF‐2013‐ 02358607 Mother‐child immunogenetic interactions in pregnancy and risk of Autism Spectrum Disorders DON GNOCCHI Guerini Franca Rosa Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD RF‐2013‐ 02358611 Paratuberculosis in sheep and goats in southern Italy, and IZSLER risk related to the consumption of dairy products contaminated by Mycobacterium avium subsp. paratuberculosis Arrigoni Norma Biomedica Veterinary Food Safety ‐ FOSA RF‐2013‐ 02358616 Security in animal nutrition: The use of formaldehyde and zinc as additives for animal feed production MACALUSO ANDREA Biomedica Veterinary Food Safety ‐ FOSA RF‐2013‐ 02358617 Campania Registry study on Acute decompensated Heart Campania Failure (CRAHF): significance, implementation and reduction of clinical outcomes BONADUCE DOMENICO Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02358622 Right Internal Thoracic Artery as Blood Supply for Saphenous Vein Bypass Graft Friuli‐Venezia Giulia Benussi Bernardo Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences ‐ BTSS RF‐2013‐ 02358627 EMerging MEditerranean BIOtoxins in fish and shellfish products: methods for the identification of algal toxins and study on the mechanism of action, trophic transfer and potential risk for the human health (EMMEBIO) IZSUM Orletti Roberta Biomedica Veterinary Food Safety ‐ FOSA IZSSI Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 307 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE Classificazione 1 Liv. Classificazione 2° liv. RF‐2013‐ 02358628 Patho‐molecular mechanisms' dissection of bicuspid aortic valve: clinical and therapeutic implications. Toscana Pepe Guglielmina Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD RF‐2013‐ 02358629 Interplay between Myeloid Derived Suppressor Cells and Hematopoietic Progenitor Cells: role in the regulation of immune response and immune reconstitution process during HIV infection. SPALLANZANI Sacchi Alessandra Biomedica AIDS and Related Research AIDS Immunology and Pathogenesis ‐ AIP RF‐2013‐ 02358630 Anti‐inflammatory effects of vagal activation in patients with ST‐elevation myocardial infarction treated with primary percutaneus coronary intervention SAN MATTEO DE FERRARI GAETANO Biomedica Cardiovascular and Respiratory Sciences Myocardial Ischemia and Metabolism ‐ MIM RF‐2013‐ 02358632 Role of anti‐LRP4 antibodies in motor neuron and neuromuscular junction alteration in ALS CARLO BESTA Mantegazza Renato Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02358633 Chronotherapy in Heart Failure:Conventional versus Temporized therapy in Heart Failure (CONVERT‐HF) Emilia‐Romagna MANFREDINI ROBERTO Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS RF‐2013‐ 02358637 Establishment of a clinical and biological (biobank) registry for chronic migraine: from knowledge of the phenomenon to implications for public health Emilia‐Romagna Manzoni Gian Camillo Clinico‐ Population Sciences and assistenzial Epidemiology e Behavioral Genetics and Epidemiology ‐ BGES RF‐2013‐ 02358638 Search for pathogenic mechanisms of haploinsufficiency Lazio of LETM1 and WHSC1 in Wolf‐Hirschhorn syndrome and therapeutic trial with Vitamin C. Zollino Marcella Biomedica Biobehavioral and Behavioral Processes Child Psychopathology and Developmental Disabilities ‐ CPDD RF‐2013‐ 02358641 Identification and validation of a Panel of suitable biomarkers useful for rAdiation Risk Assessment associated with low and protracted DOSes encountered in nuclear medicine (PARADOS) Oncology 2 ‐ Translational Clinical Radiation Therapeutics and Biology ‐ RTB Istituto Superiore di Sanita' Tabocchini Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Maria Antonella Biomedica Pagina 308 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358644 Assessing Amyloid PET Patterns in MCI patients for an improved prediction of Conversion to AD Liguria ciarmiello andrea Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02358648 Toward identification of biomarkers in patients with irritable bowel syndrome (IBS) Emilia‐Romagna Barbara Giovanni Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Gastrointestinal Mucosal Pathobiology ‐ GMPB RF‐2013‐ 02358651 An epigenetic strategy to increase chemosensitivity in cancer: Malignant Mesothelioma as a model SAN RAFFAELE MILANO Agresti Alessandra Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP RF‐2013‐ 02358653 Characterization of iPSC‐derived neurons from individuals with Autism Spectrum Disorders: an in vitro model for preclinical drug screening Toscana Canitano Roberto Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD RF‐2013‐ 02358657 ROLE OF ADIPOSE TISSUE IN THE PANCREATIC CANCER MICROENVIRONMENT Veneto ZAMBONI MAURO Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME RF‐2013‐ 02358659 Early differentiation of responders from non‐responders Friuli‐Venezia Giulia in patients with Crohn's disease through the quantitative analysis of time‐intensity curves obtained after microbubble contrast agent injection Emilio Quaia Biomedica Digestive, Kidney and Urological Systems Gastrointestinal Mucosal Pathobiology ‐ GMPB RF‐2013‐ 02358660 Authenticity of olive oil: Parameters and innovative methods to preserve the originality of Italian products ferrantelli vincenzo Biomedica Veterinary Food Safety ‐ FOSA RF‐2013‐ 02358661 Sustainability and quality of care: the role of effective Emilia‐Romagna multi‐dimensional and multi‐level PeRfOrmance management system (PMS) in healthCARE organizations (PROCARE) Nicoli Maria Augusta Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02358663 The development of a new system to optimize the treatment of Cystic Fibrosis in adults: intelligent polymeric nanovectors and microcapsules to overcome mucus barrier. A translational research to satisfy a still unmet medical need. Albera Carlo Biomedica Nanotechnology ‐ NANO IZSSI Piemonte Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Bioengineering Sciences and Technologies Classificazione 2° liv. Pagina 309 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358669 The transcription factor Prep1 as a novel molecular link for type 2 diabetes and adipocyte‐related pathologies. Campania Oriente Francesco Biomedica RF‐2013‐ 02358670 Three‐dimensional musculoskeletal ultrasound in juvenile idiopathic arthritis (JIA): development of a new, feasible tool for the assessment of disease activity and to support clinical decisions and therapeutic strategy OSPEDALE BAMBINO GESU' Magni Manzoni Silvia Clinico‐ Musculoskeletal, Oral and assistenzial Skin Sciences e Arthritis, Connective Tissue and Skin ‐ ACTS RF‐2013‐ 02358671 Inappropriate medical prescriptions: a network for patients' safety. From epidemiology to medical legal aspects: evaluation of an educative/informative strategy for prevention. Molise Campobasso Carlo Pietro Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02358673 AGEING RELATED HEART AND BONE FUNCTIONAL IMPAIRMENTS: A CLINICAL AND EXPERIMENTAL STUDY ON POTENTIALLY SHARED PATHOGENETIC PATTERNS SAN RAFFAELE MILANO fragasso gabriele Biomedica Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF RF‐2013‐ 02358675 OSPEDALE BAMBINO Integrated multidisciplinary approach and not GESU' conventional endoscopic/surgical‐based strategies in paediatric morbid obesity: clinical trials and identification of novel potential non‐invasive biomarkers for pre‐ and post‐operative monitoring DE PEPPO FRANCESCO Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO RF‐2013‐ 02358679 The prognostic value of collateral flow in acute ischemic stroke secondary to occlusion of intracranial arteries treated by endovascular therapy. SANTA LUCIA Stanzione Paolo Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Acute Neural Injury and Epilepsy ‐ ANIE RF‐2013‐ 02358680 Telehealth services for home‐based management of patients with cardiovascular disease: multidimensional assessment of Remote Monitoring in Disease Management Programs. Emilia‐Romagna De Palma Rossana Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02358683 Biological scaffold and cells for soft tissue regeneration after debulking surgery in oncologic female patients Emilia‐Romagna De Iaco Pierandrea Biomedica Clinical Oncology ‐ CONC Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Endocrinology, Metabolism, Nutrition and Reproductive Sciences Cardiovascular and Respiratory Sciences Oncology 2 ‐ Translational Clinical Cellular Aspects of Diabetes and Obesity ‐ CADO Pagina 310 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358684 Theory of mind after temporal lobe epilepsy surgery: A prospective study RF‐2013‐ 02358689 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Giovagnoli Anna Rita Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN Exploiting a cancer volatile signature from exhaled breath ISTITUTO TUMORI for breast cancer early diagnosis MILANO Orlandi Rosaria Clinico‐ Bioengineering Sciences assistenzial and Technologies e Instrumentation and Systems Development ‐ ISD RF‐2013‐ 02358690 Development of a new diagnostic tool, in the field of in vivo clinical imaging, based on a hybrid technology consisting of a combination between optical contrast (laser) and ultrasound imaging. Campania Gatta Gianluca Biomedica Biomedical Imaging Technology ‐ BMIT RF‐2013‐ 02358691 EARLY STUDY. MULTICENTER, RANDOMIZED, CLINICAL TRIAL ON THE COMPARISON BETWEENEARLY SURGERY AND CONVENTIONAL THERAPY IN INFECTIVE ENDOCARDITIS. Piemonte Cecchi Enrico Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS RF‐2013‐ 02358695 Novel pharmacological strategies for Wilson's disease cure: correction of mutant ATP7B proteins through suppression of intracellular degradation processes. From therapy to pathogenesis of damage induced by copper accumulation. Campania IORIO RAFFAELE Biomedica Cell Biology Membrane Biology and Protein Processing ‐ MBPP RF‐2013‐ 02358703 Intensity modulated clinical setting Hospitals: impact on Health Population Outcomes Agenzia per i Servizi Sanitari Regionali Davoli Marina Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02358715 Identification of biological and imaging events that predict the progression of Takayasu arteritis vascular lesions SAN RAFFAELE MILANO Sabbadini Maria Grazia Clinico‐ Immunology assistenzial e Hypersensitivity, Autoimmune, and Immune RF‐2013‐ 02358719 Metagenomics and medicine: analysis and modeling of gut and gastric microbiota in Barrett's esophagus and esophagitis. Toscana Bechi Paolo Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02358721 Colon Cancer: identification of high risk individuals through genetic screening SAN MATTEO Dionigi Paolo Biomedica Genetics of Health and Disease ‐ GHD CARLO BESTA Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Surgical Sciences, Biomedical Imaging, and Bioengineering Genes, Genomes and Genetics Pagina 311 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358722 Identification of novel genes involved in inherited Piemonte nephropathies causing end‐stage renal disease at a young age through whole exome sequencing and copy number analysis. RF‐2013‐ 02358725 Second Primary Malignancies in Thyroid Cancer Survivors: Epidemiological Impact, Pathogenetic Factors and Clinical Implications RF‐2013‐ 02358728 AN INTEGRATIVE APPROACH TO EPISODIC VERTIGO SAN RAFFAELE MILANO RF‐2013‐ 02358733 Ochratoxin A in grated cheese: occurrence, study of surface migration, risk management and regulatory activity proposal RF‐2013‐ 02358735 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Quaglia Marco Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Cellular and Molecular Biology of the Kidney ‐ CMBK frasoldati andrea Biomedica Epidemiology of Cancer ‐ EPIC Teggi Roberto Clinico‐ Molecular, Cellular, and assistenzial Developmental e Neuroscience Neurotransporters, Receptors, Channels and Calcium Signaling ‐ NTRC IZSLER BIANCARDI ALBERTO Biomedica Veterinary Food Safety ‐ FOSA Optimization of adoptive immunotherapy protocols for EBV‐driven tumors expressing a restricted pattern of subdominant viral antigens C.R.O. AVIANO Dolcetti Riccardo Biomedica Oncology 2 ‐ Translational Clinical Cancer Immunopathology and Immunotherapy ‐ CII RF‐2013‐ 02358736 Research, design, analysis, development, test and tuning of a web based informatic system even used on Tablet Android to support and coordinate all activities of inspection, monitoring and sampling aimed at improvement of data exchange with Local Health A Emilia‐Romagna ALDROVANDI AURELIO Biomedica Veterinary Animal Health ‐ ANHE RF‐2013‐ 02358738 ObeSity And renal Function in pEdiatric aGe: an epidemiological stUdy in the CAlabrian region investigating Renal dysfunction in overweight/obese aDolescents. The SAFEGUARDCKD project. Calabria Postorino Maurizio Clinico‐ Biobehavioral and assistenzial Behavioral Processes e Child Psychopathology and Developmental Disabilities ‐ CPDD RF‐2013‐ 02358741 Markers of disease progression in metabolic and cardiovascular diseases caused bymutations in lamins. RIZZOLI Lattanzi Giovanna Biomedica Genetics of Health and Disease ‐ GHD ARCISPEDALE Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Population Sciences and Epidemiology Genes, Genomes and Genetics Pagina 312 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358748 Diagnostic and therapeutic course of oncologic patients with focus on biological drugs Sardegna Minerba Luigi Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC RF‐2013‐ 02358757 Vitamin D Supplementation on Assisted Reproduction Technology (ART) outcomes: a randomized clinical controlled trial and an investigation of the involved biological mechanisms MAGGIORE Somigliana Edgardo Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Integrative and Clinical Endocrinology and Reproduction ‐ ICER RF‐2013‐ 02358765 MECHANISMS CONTROLLING COGNITIVE IMPAIRMENT IN MORBIDLY OBESE PATIENTS Lazio Raffaelli Marco Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO RF‐2013‐ 02358771 Interactions between Epstein‐Barr virus and human cytomegalovirus infections and systemic lupus erythematosus: an integrated virological, immunological and clinical analysis SAN MATTEO CAVAGNA LORENZO Biomedica Immunology Immunity and Host Defense ‐ IHD RF‐2013‐ 02358774 Robot‐assisted rehabilitation of the upper limb: a new perspective for sensory and motor training MAUGERI Colombo Roberto Biomedica Emerging Technologies and Brain Disorders and Training in Neurosciences Related Neurosciences Fellowship ‐ F01 RF‐2013‐ 02358775 Novel approaches for screening of humoral primary immunodeficiencies in adult patients Toscana Matucci Andrea Clinico‐ Immunology assistenzial e Immunity and Host Defense ‐ IHD RF‐2013‐ 02358776 The prognostic value of neoangiogenesis in Colo‐Rectal Cancer (CRC): a combination of established and innovative probe‐based Confocal Laser Endomicroscopy (pCLE) approaches C.R.O. AVIANO Cannizzaro Renato Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02358777 Amniotic stem cells to improve congenital kidney damage: a fetal lamb model SAN MATTEO Avolio Luigi Biomedica Urologic and Kidney Development and Genitourinary Diseases ‐ UKGD RF‐2013‐ 02358779 The Activity Based Management applied to a comprehensive cancer center. IRCCS AOU San Martino‐ IST (Genova) COPELLO FRANCESCO Clinico‐ Healthcare Delivery and assistenzial Methodologies e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Digestive, Kidney and Urological Systems Classificazione 2° liv. Health Services Organization and Delivery ‐ HSOD Pagina 313 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358782 Butyrate as innovative therapeutic strategy against pediatric obesity complications Campania Franzese Adriana Biomedica RF‐2013‐ 02358785 Effects of multimodal training on cognition, biomarkers, rs‐FMRI and brain structural integrity in MCI patients Abruzzo Sensi Stefano Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02358786 Study of the molecular mechanisms underlying oncogene‐ I.E.O. dependent DNA replication stress Dellino Gaetano Ivan Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP RF‐2013‐ 02358787 Therapies for inborn errors of metabolism Campania Brunetti Pierri Nicola Biomedica Genes, Genomes and Genetics Gene Therapy and Inborn Errors ‐ GTIE Special Emphasis Panel RF‐2013‐ 02358790 Olfaction as an index of conversion from MCI to AD: a longitudinal functional connectivity study Emilia‐Romagna Nichelli Paolo Frigio Biomedica Integrative, Functional, and Cognitive Neuroscience Somatosensory and Chemosensory Systems ‐ SCS RF‐2013‐ 02358792 Clinical Validation of a new Low Cost Point‐of‐Care system for bilirubin determination in newborns ‐ Impact on hyperbilirubinemia prevention and cost reduction for the National Health System (SSN) BURLO GAROFALO Travan Laura Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Pregnancy and Neonatology ‐ PN RF‐2013‐ 02358793 Identification of small molecules active against HIV‐1 memory T cell reservoirs through the inhibition of their homeostatic proliferation Istituto Superiore di Sanita' Battistini Angela Biomedica AIDS Discovery and Development of Therapeutics ‐ ADDT RF‐2013‐ 02358798 Association between long‐term exposure to air pollution and neurological and metabolic impairment in adults of two large Italian longitudinal studies Piemonte Galassi Claudia Clinico‐ Population Sciences and assistenzial Epidemiology e Social Sciences and Population Studies ‐ SSPS RF‐2013‐ 02358799 Intrauterine prevention of perinatal and early infancy obesity Emilia‐Romagna facchinetti fabio Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Pregnancy and Neonatology ‐ PN Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Endocrinology, Metabolism, Nutrition and Reproductive Sciences AIDS and Related Research Diabetes, Metabolism, Nutrition and Obesity Small Business SEP (EMNR E10 B) Pagina 314 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA RF‐2013‐ 02358809 Design of innovative composite biomaterials using transglutaminase‐mediated cross‐links for bone tissue regeneration and possible applications for therapy. Sicilia Ientile Riccardo RF‐2013‐ 02358811 GUT MICROBIOTA AND INFLAMMASOME IN THE PATHOGENESIS OF ALZHEIMER¿S DISEASE DON GNOCCHI Clerici Mario Salvatore Biomedica RF‐2013‐ 02358812 Isolation, immunophenotypic‐molecular‐biological characterization and banking of human mesenchymal stem cells; identification of novel, sustainable methods for ex vivo expansion and uni‐lineage differentiation for clinical applications Calabria Gasparini Giorgio RF‐2013‐ 02358816 Preclinical assessment of the radiosensitizing activity of NEDD8 pathway inhibition in rectal cancer Istituto Oncologico Candiolo Gabriele RF‐2013‐ 02358819 Identification of neuronal substrates of Phelan‐ McDermid syndrome to identify therapies in preclinical models: correlation between clinical outcome and molecular phenotypes of human neurons derived from patient¿s hiPS cells CARLO BESTA RF‐2013‐ 02358822 Standardization of innovative methods of molecular diagnostics for the development of a prognostic and therapeutic personalized approach to patients affected with colo‐rectal cancer Lazio RF‐2013‐ 02358823 RF‐2013‐ 02358824 P.I. Classificazione 2° liv. Bioengineering Sciences and Technologies Biomaterials and Biointerfaces ‐ BMBI Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN Biomedica Musculoskeletal, Oral and Skin Sciences Musculoskeletal Tissue Engineering ‐ MTE Pietro Biomedica Oncology 2 ‐ Translational Clinical Radiation Therapeutics and Biology ‐ RTB D'Arrigo Stefano Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD Ruggeri Enzo Maria Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS Immune‐ and DNA repair‐related gene signatures for the HUMANITAS prediction of risk of tumour recurrences and brain metastasis in HER2‐positive breast cancer patients Santarpia Libero Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS Alzheimer's disease as a systemic disorder: molecular targets and clinical correlates BERNARDINI RENATO Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND Sicilia Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Biomedica Classificazione 1 Liv. Pagina 315 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358838 Influence of phosphate metabolism in the clinical phenotype and pathogenesis of bone, mineral and cardiometabolic disorders CASA SOLLIEVO SOFFERENZA Battista Claudia Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative Nutrition and Metabolic Processes ‐ INMP RF‐2013‐ 02358839 Novel biomarkers and therapy targets for Anaplastic Thyroid Carcinoma therapy: the BAG3‐BRAF pathway PASCALE Chiappetta Gennaro Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP RF‐2013‐ 02358840 The apicoplast translational apparatus as a target for the development and characterization of new antimalarial agents. Istituto Superiore di Sanita' Menegon Michela Biomedica Infectious Diseases and Microbiology Drug Discovery and Mechanisms of Antimicrobial Resistance ‐ DDR RF‐2013‐ 02358842 Medium‐ and long‐term comparative effectiveness and costs analysis of TAVI vs AVR in patients with severe symptomatic aortic stenosis at medium‐low risk Sicilia Tamburino Corrado Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02358845 Comparison of personality and peripheral biological markers in young Italians with and without internet addiction Toscana Dell'Osso Liliana Biomedica Pathophysiological Basis of Mental Disorders and Addictions ‐ PMDA RF‐2013‐ 02358848 Report‐AGE Project: clinical and biological predictors of physical function decline in older patients with chronic cardiovascular diseases I.N.R.C.A. Bustacchini Silvia Clinico‐ Biology of Development assistenzial and Aging e Aging Systems and Geriatrics ‐ ASG RF‐2013‐ 02358849 Bactericidal/permeability‐increasing fold‐containing‐ family‐B‐member‐4 as a new therapeutic target to fight cardiovascular diseases NEUROMED Vecchione Carmine Biomedica Cardiovascular and Respiratory Sciences Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR RF‐2013‐ 02358851 Reduced aspirin action in diabetic patients at high risk of Istituto Superiore di Sanita' Guerriero cardiovascular events: cellular and molecular studies on megakaryocyte progenitor cells and platelets. Raffaella Biomedica Vascular and Hematology Hemostasis and Thrombosis ‐ HT RF‐2013‐ 02358854 Beta‐cell genes and diabetes: from MODY to atypical type Emilia‐Romagna 1 or type 2 diabetes Vilma Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD Mantovani Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Brain Disorders and Clinical Neuroscience Classificazione 2° liv. Pagina 316 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358855 Unmasking organ‐confined prostate tumors with highly‐ invasive profile SAN RAFFAELE MILANO Cavarretta Ilaria Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02358858 DISSECTION OF FATTY ACID SYNTHASE ROLE AS A DETERMINANT OF DRUG RESPONSE AND RESISTANCE IN DIFFUSE MALIGNANT PERITONEAL MESOTHELIOMA THROUGH THE INTEGRATION OF GENE AND microRNA PROFILES ISTITUTO TUMORI MILANO Perego Paola Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT RF‐2013‐ 02358860 DIMCAT: Don Gnocchi ICF‐Info Multicenter Clinical Application Trial DON GNOCCHI Negrini Stefano Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02358864 Integration of information sources (administrative and textual databases plus clinical registries) into models for quality evaluation, outcome analysis, technology and economic assessment, and support for clinical decision and healthcare planning ‐ focus Lombardia Maria Frigerio Clinico‐ Risk, Prevention and assistenzial Health Behavior e Behavioral Medicine: Interventions and Outcomes ‐ BMIO RF‐2013‐ 02358867 FTD genotype‐phenotype correlation in two population clusters with common genetic background living in different continents. Calabria Colao Rosanna Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02358871 Discovery of distinct plasma micro‐RNA expression pattern in endometriosis and endometriosis‐associated ovarian cancer Sicilia Corsello Salvatore Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02358872 Common pathogenic steps in neuromuscular diseases: dissecting the role of miR‐21 and miR‐206 in SMA and ALS mice and human patients. CARLO BESTA Locatelli Denise Biomedica Molecular, Cellular, and Developmental Neuroscience Cellular and Molecular Biology of Neurodegeneration ‐ CMND RF‐2013‐ 02358877 Comparative effectiveness of a home‐care telemedicine intervention to monitor the respiratory performance of patients with ALS. Friuli‐Venezia Giulia Pisa Federica‐Edith Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Clinical Neuroscience and Neurodegeneration ‐ CNN Pagina 317 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358880 GENE‐ENVIRONMENT INTERACTIONS IN SARCOIDOSIS. ROLE OF ENVIRONMENTAL INFLUENCES ON SARCOIDOSIS SUSCEPTIBILITY GENES Emilia‐Romagna RF‐2013‐ 02358881 Lipid biomarkers of neuroaxonal damage for disability progression prediction in Multiple Sclerosis RF‐2013‐ 02358885 Reduction into practice of a clinical grade stem cell marker‐based signature for the prognostic prediction of breast cancer. RF‐2013‐ 02358889 Comparing attendance rate and advanced neoplasia yield Piemonte of colonoscopy and yearly FIT for post‐polypectomy surveillance of patients with intermediate and high‐risk adenomas RF‐2013‐ 02358890 Flavors and metabolic alterations related to improper feeding behavior in mammals RF‐2013‐ 02358891 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Giuseppina Biomedica Cardiovascular and Respiratory Sciences Lung Injury, Repair, and Remodeling ‐ LIRR Istituto Superiore di Sanita' Minghetti Luisa Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT I.E.O. Pece Salvatore Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS Senore Carlo Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD Istituto Superiore di Sanita' Guidotti Marco Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences (EMNR) Integrated Review Group Fellowship Panel ‐ F06 Role of FDG positron emission tomography (PET) and immunological markers in predicting outcome in large‐ vessel vasculitides (giant cell arteritis and Takayasu arteritis) ARCISPEDALE Pipitone Nicolò Clinico‐ Vascular and Hematology assistenzial e Atherosclerosis and Inflammation of the Cardiovascular System ‐ AICS RF‐2013‐ 02358892 Cell therapy clinical trial with Mesenchymal Stem Cells (MSCs) as vehicle to deliver paclitaxel for the treatment of lung metastatic tumours in dogs IZSSI Guercio Annalisa Biomedica Oncology 2 ‐ Translational Clinical Developmental Therapeutics ‐ DT RF‐2013‐ 02358893 Exploring the role of genetics in juvenile stroke: an exome pilot study. Toscana Nencini Patrizia Biomedica Brain Disorders and Clinical Neuroscience Brain Injury and Neurovascular Pathologies ‐ BINP Bertorelli Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Endocrinology, Metabolism, Nutrition and Reproductive Sciences Pagina 318 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO RF‐2013‐ 02358895 Lombardia Three‐Month Weekly Rifapentine/Isoniazid Versus 6‐ Month Self‐administered Daily Isoniazid with or without SMS Reminders for the Treatment of Latent Tuberculosis Infection among Immigrants in Italy: a Randomized Clinical Trial RF‐2013‐ 02358905 DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Alberto Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS Istituto Superiore di Sanita' Ambrosini Elena Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD Musculoskeletal, Oral and Skin Sciences Skeletal Muscle Biology and Exercise Physiology ‐ SMEP Matteelli Next‐generation sequencing and new disease models to identify the molecular mechanisms and therapeutic targets of astrocyte dysfunction in autism‐epilepsy phenotype RF‐2013‐ 02358910 Targetting the interleukin‐6 receptor as a novel therapeutic approach in Duchenne muscular dystrophy to modulate muscle inflammation and regeneration OSPEDALE BAMBINO GESU' de benedetti fabrizio Biomedica RF‐2013‐ 02358919 Fluorescence‐guided surgical resection of high grade gliomas with sodium fluorescein: a phase III clinical trial CARLO BESTA Broggi Morgan Aldo Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC RF‐2013‐ 02358938 Epidemiology and cost evaluation of stroke in Italy Toscana Lamassa Maria Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02358940 GENDER RELATED INSIGHT INTO CARDIOVASCULAR Toscana RISK: A SYSTEM MEDICINE APPROACH Abbate Rosanna Biomedica SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan ‐ TPM1 RF‐2013‐ 02358941 Rigorous maintenance of normoxia versus hyperoxia in critically ill patients admitted in intensive care unit. A randomized multicentre study. Rinaldi Laura Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Brain Injury and Neurovascular Pathologies ‐ BINP RF‐2013‐ 02358944 Add‐on short‐term therapy with pegylated interferon alfa Lazio in patients with HBeAb positive chronic hepatitis B who are long‐term responders to nucleos(t)ide treatment: does it allow complete withdrawal of antiviral therapy and does it reduce the risk of liv Angelico Mario Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Hepatobiliary Pathophysiology ‐ HBPP Emilia‐Romagna Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Risk, Prevention and Health Behavior Pagina 319 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358945 DATA MINING IN CLINICAL TRIALS: INVESTIGATING SYMPTOM NETWORKS TO IMPROVE THERAPEUTIC STRATEGIES FOR MAJOR DEPRESSION Istituto Superiore di Sanita' Giuliani Alessandro Biomedica RF‐2013‐ 02358947 Viral persistence, chronic immune activation, and drug penetration in the Central Nervous System of HIV‐ infected subjects: predictors of viral compartmentalization in cerebrospinal fluid and clinical outcomes (CENES Study). SPALLANZANI Perno Carlo Federico Clinico‐ AIDS and Related Research assistenzial e AIDS Immunology and Pathogenesis ‐ AIP RF‐2013‐ 02358952 Renal Denervation in Patients with Advanced ChronicHeart Failure (NYHA f. C. III), Needing High Loop Diuretic Dose. MULTIMEDICA Gronda Edoardo Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS RF‐2013‐ 02358960 Distinct developmental programs of cord blood and bone OSPEDALE BAMBINO marrow haematopoietic stem cells reconstitute different GESU' B‐cell compartments in transplanted patients leading to transplant‐specific immune impairment. Cellular and molecular characterization of transi Carsetti Rita Biomedica Immunology Immunity and Host Defense ‐ IHD RF‐2013‐ 02358967 Development of innovative compoundsfor the treatment Abruzzo of renal cell carcinoma and Von Hippel‐Lindau Syndrome Tinari Nicola Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT RF‐2013‐ 02358970 NEURO‐SCD: Sudden Cardiac Death (SCD) and Neuropsychiatric drugs consumption. Pascali Vincenzo Lorenzo Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Electrical Signaling, Ion Transport, and Arrhythmias ‐ ESTA RF‐2013‐ 02358971 Sicilia Comparisons of Hepatic Transient Elastography and Acoustic Radiation Force Impulse Measurements of Liver and Spleen, Performed Before Liver Biopsy. Catalano Daniela Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Clinical, Integrative and Molecular Gastroenterology ‐ CIMG RF‐2013‐ 02358973 Organic vs conventional: spreading assessment of certain IZSSA dairy herds diseases Orrù Andrea Biomedica Animal Health ‐ ANHE Lazio Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Biobehavioral and Behavioral Processes Veterinary Adult Psychopathology and Disorders of Aging ‐ APDA Pagina 320 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358984 Validation of PTEN as diagnostic, prognostic and therapeutic predictive bio‐marker in colorectal cancer and identification of new therapeutic targets. Campania De Rosa Marina Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP RF‐2013‐ 02358985 Epigenetics in dystrophic epidermolysis bullosa: towards novel therapies to counteract dermal fibrosis and carcinoma development ISTITUTO DERMOPATICO DELL'IMMACOLATA Castiglia Daniele Biomedica Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ‐ ACTS RF‐2013‐ 02358987 Role of the motor cortex in the pathogenesis of the Amyotrophic Lateral Sclerosis disease SANTA LUCIA Zona Cristina Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN RF‐2013‐ 02358988 Identification of health interventions to be offered to populations living in areas affected by environmental pollution: development and pilot application of an evidence‐based approach. Piemonte Migliore Enrica Clinico‐ Population Sciences and assistenzial Epidemiology e Social Sciences and Population Studies ‐ SSPS RF‐2013‐ 02358989 Impact of intermittent and continuous hypoxia on factors AUXOLOGICO determining the development of atherosclerosis and cardiovascular risk in hypertensive subjects with obesity and metabolic disorders. Bilo Grzegorz Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS RF‐2013‐ 02358990 Functional link between myeloid suppressor cells and inhibition of protective T cell responses in melanoma patients. GALEAZZI Reali Eva Biomedica Immunology Transplantation, Tolerance and Tumor Immunology ‐ TTT RF‐2013‐ 02358991 Acoustic Spectroscopy of Lung Toscana Demi Marcello Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Biomedical Imaging Technology ‐ BMIT RF‐2013‐ 02358992 Strength and resistance Exercise Therapy (ET) to control PASCALE Aromatase Inhibitors (AIs) muscloskeletal adverse effects and improve Quality of Life (QoL) in elderly breast cancer survival women Pinto Monica Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC RF‐2013‐ 02358994 FOODBORNE BOTULISM IN ITALY: IMPROVEMENT OF MEASURES FOR DIAGNOSIS, PREVENTION AND CONTROL OF THE DISEASE Dario Biomedica Food Safety ‐ FOSA Istituto Superiore di Sanita' De Medici Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Veterinary Classificazione 2° liv. Pagina 321 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02358998 Investigating heparanase in synovial sarcoma as a target of innovative therapies RF‐2013‐ 02358999 OSPEDALE BAMBINO A three‐year research project conducted in a pediatric hospital cardiology unit designed to investigate whether GESU' actively eliciting preferences and wishes in young patients with heart failure and their parents in evidence‐based diagnostic and therapeutic o RF‐2013‐ 02359002 No more emergencies in DNA species identification: development and harmonization of molecular and next generation methods to determine and quantify origin species in food and to discriminate frauds from unintentional contamination. RF‐2013‐ 02359005 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Lanzi Cinzia Biomedica Rosati Paola Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD IZSPLV Peletto Simone Biomedica Veterinary Food Safety ‐ FOSA Oxidative stress and early pregnancy complications Lazio Piccione Emilio Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Pregnancy and Neonatology ‐ PN RF‐2013‐ 02359009 EFFECTS ON THE INHALATION OF MOUNT ETNA'S VOLCANIC ASHES AND HEALTH RISK: STUDY IN VITRO OF THE POTENTIAL ALTERATIONS IN THE INNATE IMMUNOLOGIC RESPONSE AND IN THE ALVEOLAR ENVIRONMENT Sicilia CRIMI NUNZIO Biomedica Cardiovascular and Respiratory Sciences Lung Cellular, Molecular, And Immunobiology ‐ LCMI RF‐2013‐ 02359012 Effects of continuous and intermittent long‐term letrozole administration on cognitive function in post‐ menopausal breast cancer patients I.E.O. Pravettoni Gabriella Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02359014 Box‐of‐rain for Critical limb ischemia: a phase II single arm trial. SAN MATTEO Argenteri Angelo Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Cardiovascular Differentiation and Development ‐ CDD RF‐2013‐ 02359024 GAIT ROBOTIC REHABILITATION IN CHILDREN WITH CONGENITAL OR ACQUIRED BRAIN INJURIES OSPEDALE BAMBINO GESU' Castelli Enrico Clinico‐ Emerging Technologies and Brain Disorders and assistenzial Training in Neurosciences Related e Neurosciences Fellowship ‐ F01 ISTITUTO TUMORI MILANO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT Pagina 322 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359025 LIPID METABOLISM AND VASCULAR HEALTH IN MORBID OBESITY: IMPACT OF BARIATRIC SURGERY Umbria LUPATTELLI GRAZIANA Clinico‐ Vascular and Hematology assistenzial e Atherosclerosis and Inflammation of the Cardiovascular System ‐ AICS RF‐2013‐ 02359030 CoNan ‐ Cobalt Nanoparticles for Multimodal Molecular Imaging Emilia‐Romagna Marengo Mario Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Biomedical Imaging Technology ‐ BMIT RF‐2013‐ 02359033 Molecular dissection of the cross‐talk between cell plasticity and autophagy in breast cancer C.R.O. AVIANO Santarosa Manuela Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP RF‐2013‐ 02359034 Impact of Digital Information and Libraries on Levels of care, Interventions, and Outcomes: IDILLIO Study. Lazio Vecchi Simona Clinico‐ Healthcare Delivery and assistenzial Methodologies e Biomedical Computing and Health Informatics ‐ BCHI RF‐2013‐ 02359036 Integrated approach to optimize the treatment with S(+)‐ Provincia autonoma escitalopram in MDD patients. Bolzano Andreas Conca Clinico‐ Biobehavioral and assistenzial Behavioral Processes e Adult Psychopathology and Disorders of Aging ‐ APDA RF‐2013‐ 02359043 A PHASE II STUDY OF AUTOLOGOUS BONE MARROW DERIVED STEM CELL TRANSPLANTATION FOR THE TREATMENT OF CHRONIC END STAGE LIVER DISEASE. Emilia‐Romagna Andreone Pietro Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Hepatobiliary Pathophysiology ‐ HBPP RF‐2013‐ 02359046 Functional and molecular characterization of the epigenetic network that controls gene expression during neurogenic muscle atrophy: new potential targets for therapies against muscle wasting caused by neurogenic disorders and aging. SANTA LUCIA BERGHELLA LIBERA Biomedica Skeletal Muscle Biology and Exercise Physiology ‐ SMEP RF‐2013‐ 02359049 Muscular vibration asociated with transcranial magnetic stimulation may relieve spasticity in patients with multiple sclerosis NEUROLESI MILARDI DEMETRIO Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Musculoskeletal, Oral and Skin Sciences Classificazione 2° liv. Clinical Neuroscience and Neurodegeneration ‐ CNN Pagina 323 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359051 Diet, PCDD/F, PCB, OCP, BPA, OP and NP exposure, intrauterine and early postnatal growth, DNA methylation and childhood obesity risk Veneto MAFFEIS CLAUDIO Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative Physiology of Obesity and Diabetes ‐ IPOD RF‐2013‐ 02359052 Non‐invasive prenatal testing: fetal aneuploidies risk determination, mutation analysis in pregnancies at risk for monogenic disorders and circulating cell free DNA dosage as a marker of pregnancy outcome. Toscana Torricelli Francesca Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD RF‐2013‐ 02359059 SPALLANZANI Use of next generation sequencing‐based metagenomic approach to improve the etiologic diagnosis of acute non bacterial meningoencefalitis Capobianchi Maria Rosaria Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS RF‐2013‐ 02359063 Toscana Biomechanical characterization of Carotid Plaque by innovative ultrasound in stroke(BioCaP): Validation Against Magnetic Resonance Imaging and Immunoistochemistry of Radiofrequency‐Based Methods Integrating 3D Imaging and Flow Velocity Distribution, and Palombo Carlo Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences ‐ BTSS RF‐2013‐ 02359065 Targeting mitochondrial calcium handling in core myopathies: an integrative approach towards novel therapeutic strategies Veneto Pegoraro Elena Biomedica Musculoskeletal, Oral and Skin Sciences Skeletal Muscle Biology and Exercise Physiology ‐ SMEP RF‐2013‐ 02359068 Risk Communication for food borne disease prevention IZSME Baldi Loredana Biomedica Veterinary Food Safety ‐ FOSA RF‐2013‐ 02359070 Panallergens in Pediatrics: evolution of the molecular allergenic profile in children with pollinosis Emilia‐Romagna Ricci Giampaolo Biomedica Population Sciences and Epidemiology Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions ‐ IRAP RF‐2013‐ 02359074 Identifying preclinical phenotypic and biological markers SANTA LUCIA of Alzheimer's Disease in healthy elderly at risk subjects Caltagirone Carlo Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Clinical Neuroscience and Neurodegeneration ‐ CNN Pagina 324 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359076 A prospective randomized study for outpatient management of chronic heart failure: Lung Ultrasound and Noninvasive Central Venous Pressure Measurement as additional diagnostic tools to standard physical examination SAN RAFFAELE MILANO Agricola RF‐2013‐ 02359077 Identification of early and predictive markers of individual risk for head and neck cancer Toscana RF‐2013‐ 02359078 ROLE OF HLA AND NATURAL KILLER CELL RECEPTORS IN THE OUTCOME OF CYTOMEGALOVIRUS (CMV) INFECTION: GENETIC AND FUNCTIONAL ANALYSIS OF KILLER IMMUNOGLOBULIN‐LIKE RECEPTORS (KIR), HLA AND NKG2 RECEPTORS VARIANTS IN THE CONTROL OF CMV INFECTION RF‐2013‐ 02359082 Classificazione 1 Liv. Classificazione 2° liv. Eustachio Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF GALLO ORESTE Biomedica Oncology 1 ‐ Basic Translational Cancer Etiology ‐ CE Sicilia DI BONA DANILO Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD Understanding the interaction between inflammatory factors profile in stroke patients to design a tailored therapeutic approach MONDINO Candeloro Elisa Biomedica Brain Disorders and Clinical Neuroscience Brain Injury and Neurovascular Pathologies ‐ BINP RF‐2013‐ 02359084 e‐Governance for the smart management of people with cognitive disorders and dementia Calabria Gareri Pietro Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02359088 Role of the Transcriptional Repressor REST/NRSF in Neuroinflammation HUMANITAS Pozzi Davide Biomedica Molecular Neuropharmacology and Signaling ‐ MNPS RF‐2013‐ 02359089 CARLO BESTA Implementation of innovative procedures for the treatment of cortical myoclonus, using non‐invasive repetitive Transcranial Magnetic Stimulation: assessment of clinical efficacy with standardized scales and monitoring of the changes on cortical excitabili Canafoglia Laura Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroplasticity and Neurotransmitters ‐ CNNT RF‐2013‐ 02359090 Dual targeting of histone lysine demethylase 1 (KDM1a) and histone deacetylases (HDACs) or retinoids with bifunctional inhibitors as novel anticancer agents Varasi Mario Biomedica Tumor Cell Biology ‐ TCB I.E.O. Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Molecular, Cellular, and Developmental Neuroscience Oncology 1 ‐ Basic Translational Pagina 325 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359091 Tumor characteristics and sensitivity to different treatments in human pancreatic adenocarcinoma : towards an individualized therapy of cancer Lombardia Moroni Mauro Biomedica RF‐2013‐ 02359096 Future scenario in HCV infection therapies: identification Lombardia of viral determinants of treatment outcome success Micheli Valeria Clinico‐ Infectious Diseases and assistenzial Microbiology e Infectious Diseases and Microbiology Fellowship ‐ F13 RF‐2013‐ 02359098 Comprehensive genetic analysis in Parkinson Disease. Campania Criscuolo Chiara Biomedica Genetics of Health and Disease ‐ GHD RF‐2013‐ 02359102 Frequency, impact on the pregnancy, and long‐term clinical outcomes on the mother and the fetus of pregnancy‐associated cancers: a record‐linkage study. MARIO NEGRI Tavani Alessandra Clinico‐ Population Sciences and assistenzial Epidemiology e Epidemiology of Cancer ‐ EPIC RF‐2013‐ 02359103 SELF REACTIVE T CELLS IN SEVERE OSTEOPOROSIS Piemonte D'AMELIO PATRIZIA Biomedica Aging Systems and Geriatrics ‐ ASG RF‐2013‐ 02359111 New‐onset diabetes after transplantation (NODAT) and glucocorticoids therapy: looking for clinical, biochemical and genetics determinants Marche ARNALDI GIORGIO Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Molecular and Cellular Endocrinology ‐ MCE RF‐2013‐ 02359112 A SYSTEMYC APPROACH TO ENSURE THE SAFETY OF SICILIAN FOOD PRODUCTS IZSSI MARINO ANNA MARIA FAUSTA Biomedica Veterinary Food Safety ‐ FOSA RF‐2013‐ 02359121 EVALUATING THE COST‐EFFECTIVENESS OF AN Sicilia ORGANIZATIONAL MODEL OF RISK ANALYSIS AND PROBLEM SOLVING FOR HEALTHCARE‐ASSOCIATED INFECTIONS DELIA Santi Antonino Clinico‐ Infectious Diseases and assistenzial Microbiology e Infectious Diseases and Microbiology Fellowship ‐ F13 RF‐2013‐ 02359124 Influence of diabetes mellitus on tuberculosis: is autophagy dysfunction the missing link? Fimia Gian Maria Biomedica Host Interactions with Bacterial Pathogens ‐ HIBP RF‐2013‐ 02359130 CANCER IN IMMUNOCOMPROMIzED POPULATIONS: C.R.O. AVIANO NEW SURVEILLANCE STRATEGIES FOR SOLID TUMOURS Vaccher Emanuela Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e SPALLANZANI Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Oncology 2 ‐ Translational Clinical Genes, Genomes and Genetics Biology of Development and Aging Infectious Diseases and Microbiology Basic Mechanisms of Cancer Therapeutics ‐ BMCT Clinical Oncology ‐ CONC Pagina 326 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359131 Hospital‐home clinical pathways in neurorehabilitation: cost‐effective evaluation of advanced technologies supporting case management and rehabilitation care NEUROMED Bartolo Michelangelo Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02359133 Personalized treatment of early/locally advanced and metastatic breast cancer patients by genomic analysis Abruzzo Ficorella Corrado Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02359135 Clinical, genetics and epidemiological assessment of familial and sporadic frontotemporal dementias in a population‐based study with the validation of a clinical‐ based cohort. CASA SOLLIEVO SOFFERENZA Seripa Davide Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02359136 Outcome and socio‐economic impact of the definitive treatment for the cardiac device‐related infections Sicilia Calvagna Giuseppe Mario Clinico‐ RF‐2013‐ 02359139 Delivering cognitive stimulation through telecommunication technology to prevent dementia S.CAMILLO Cagnin Annachiara RF‐2013‐ 02359147 Action observation treatment to improve cortical plasticity and upper limb functions in chronic stroke patients: a RCT study from basic neuroscience to traditional and home‐based clinical rehabilitation. SAN RAFFAELE PISANA FRANCESCHI MARCO NI Clinico‐ Biobehavioral and assistenzial Behavioral Processes e Motor Function, Speech and Rehabilitation ‐ MFSR RF‐2013‐ 02359150 Cutaneous and uterine leyomyomatosis occurrence and fumarate hydratase gene expression: a potential new diagnostic algorithm for the screening of the risk of cavernomas and cerebrovascular accidents Lazio Orlandi Augusto Clinico‐ Risk, Prevention and assistenzial Health Behavior e SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan ‐ TPM1 RF‐2013‐ 02359151 A multidisciplinary investigation on the early stages of dementia aimed to identify older people with cognitive frailty Veneto GALLUCCI MAURIZIO Biomedica Clinical Neuroscience and Neurodegeneration ‐ CNN Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Healthcare Delivery and assistenzial Methodologies e Classificazione 2° liv. Health Services Organization and Delivery ‐ HSOD Clinico‐ Emerging Technologies and Brain Disorders and assistenzial Training in Neurosciences Related e Neurosciences Fellowship ‐ F01 Brain Disorders and Clinical Neuroscience Pagina 327 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359152 Evaluation of Biomarkers of Resistance/Sensitivity to different Adjuvant Endocrine Treatments in a Randomized Clinical Trial to Optimize Treatment Decision‐Making and to Identify Novel Pharmacological Targets in Estrogen Receptor (ER)‐Positive Breast Canc PASCALE RF‐2013‐ 02359153 Single chain antibodies and transcription activator like effector protein: a combined biotechnologies for advanced therapeutic approach against HIV/AIDS Istituto Superiore di Sanita' Titti RF‐2013‐ 02359155 Emilia‐Romagna Use of electrical stimulation in the rehabilitation of dysphagia after stroke: randomized controlled trial to test the effectiveness of treatment on outcome RF‐2013‐ 02359159 Regenerative Networks: Influence of adipose‐derived stromal fraction on skin repair RF‐2013‐ 02359161 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Michelino Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS Fausto Biomedica AIDS and Related Research AIDS Discovery and Development of Therapeutics ‐ ADDT Antenucci Roberto Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Brain Injury and Neurovascular Pathologies ‐ BINP SAN GALLICANO Bellei Barbara Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Bioengineering, Technology, and Surgical Sciences ‐ BTSS A POPULATION BASED STUDY ON THE RELATIONSHIP BETWEEN EXPOSURE TO OUTDOOR AIR POLLUTION AND CIRCULATING BIOMARKERS. MAGGIORE MANNUCCI PIER MANNUCCIO Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR RF‐2013‐ 02359162 Phosphotargeting of NG2/CSPG4 in Chordoma ISTITUTO TUMORI MILANO Tamborini Elena Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Basic Mechanisms of Cancer Therapeutics ‐ BMCT RF‐2013‐ 02359165 Self‐Expandable Metal Stents As ¿Bridge‐To‐Surgery¿ Treatment For Acute Malignant Colonic Obstruction Sicilia Di Mitri Roberto Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Clinical, Integrative and Molecular Gastroenterology ‐ CIMG RF‐2013‐ 02359166 Development of synthesis tools for orthopaedic surgery using biomaterials based on custom made 3D printing technology Toscana Calvosa Giuseppe Biomedica Bioengineering, Technology, and Surgical Sciences ‐ BTSS De Laurentiis Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Surgical Sciences, Biomedical Imaging, and Bioengineering Pagina 328 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359169 PROJECT TITLE: ArmòniaResearch‐action of work related stress and psychosocial risk assessment in a Healthcare Enstablisment Sicilia RF‐2013‐ 02359174 Discovery of Tat mimicking compounds to fight HIV latency Istituto Superiore di Sanita' Sgarbanti RF‐2013‐ 02359176 TISSUE ENGINEERING IN ORGAN TRASPLANTATION: Sicilia THE USE OF POLYMERIC SCAFFOLDS IN HEPATIC VASCULAR AND BILIARY RECOSTRUCTION RF‐2013‐ 02359179 Vitamin D to improve cellular killing of HIV‐1. Classificazione 1 Liv. Classificazione 2° liv. MARCO Clinico‐ Risk, Prevention and assistenzial Health Behavior e Social Psychology, Personality and Interpersonal Processes ‐ SPIP Marco Biomedica AIDS and Related Research AIDS Discovery and Development of Therapeutics ‐ ADDT Ricotta Calogero Antonio Carmelo Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Bioengineering, Technology, and Surgical Sciences ‐ BTSS Nardacci Roberta Biomedica AIDS and Related Research AIDS Discovery and Development of Therapeutics ‐ ADDT RF‐2013‐ 02359182 The impact of the Internal Body Perception and image in SANTA LUCIA Aging: development of an innovative tool Lucci Giuliana Clinico‐ Biology of Development assistenzial and Aging e Aging Systems and Geriatrics ‐ ASG RF‐2013‐ 02359186 I.N.R.C.A. Fractal Lacunarity of Trabecular Bone in Magnetic Resonance Images of Lumbar Vertebras: Clinical Validation of a New Diagnostic Tool for Osteoporosis and Fracture Risk Zaia Annamaria Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Computational modeling and sciences for biomedical and clinical applications ‐ ZRCM RF‐2013‐ 02359190 Off‐label use of sildenafil in newborn and infants with pulmonary hypertension: pharmacogenetic/ pharmacokinetic analysis and possible influence on cognitive functions OSPEDALE BAMBINO GESU' testa giuseppina Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS RF‐2013‐ 02359193 Reprogramming and stemness in ovarian cancer: function, signatures and clinical relevance I.E.O. TESTA GIUSEPPE Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP RF‐2013‐ 02359199 Molecular bases of host‐pathogen interaction in brucellosis: comparative study in dairy large ruminants. IZSME Martucciello Alessandra Biomedica Veterinary Animal Health ‐ ANHE SPALLANZANI CREMA Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Pagina 329 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359200 Pleiotropic effects of proprotein convertase subtilisin kexin type 9 (PCSK9) targeting: focus on extra hepatic tissues. RF‐2013‐ 02359203 AREA P.I. Classificazione 1 Liv. CATAPANO ALBERICO LUIGI Biomedica I.N.R.C.A. A long‐term evaluation of the impact of a complex intervention to support Alzheimer's Disease patients and their caregivers. The "Up‐Tech 2" project Rimland Joseph Morton Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02359204 Cancer and adolescence: improve understanding of clinical and traslational research C.R.O. AVIANO Mascarin Maurizio Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02359207 Analytical determination and exposure assessment of nanomaterials in food Istituto Superiore di Sanita' Cubadda Francesco Biomedica Veterinary Food Safety ‐ FOSA RF‐2013‐ 02359209 Integrated use of multiple techniques for the understanding and treatment of spatial awareness and motor disorders following stroke Piemonte De Mattei Marco Biomedica Brain Disorders and Clinical Neuroscience Brain Injury and Neurovascular Pathologies ‐ BINP RF‐2013‐ 02359210 A e‐health Application for the management of Alcohol Use Disorders: A Randomized Clinical Trial Lazio Addolorato Giovanni Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Pathophysiological Basis of Mental Disorders and Addictions ‐ PMDA RF‐2013‐ 02359213 Development of radiolabeled amyloid‐seeking agents based on protein and peptide scaffolds for PET imaging SAN MATTEO Lodola Lorenzo Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Medical Imaging ‐ MEDI RF‐2013‐ 02359216 IZSPLV A new immunotherapy option for oral melanoma and other canine malignant tumors using a DNA vaccine coding for human chondroitin sulphate proteoglycan 4 (CSPG4), integrated with the validation of candidate gene useful for therapeutic opportunities and prog Ferrari Angelo Biomedica Veterinary Animal Health ‐ ANHE MULTIMEDICA Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Cardiovascular and Respiratory Sciences Classificazione 2° liv. Physiology and Pathobiology of Cardiovascular and Respiratory Systems ‐ PPCR Pagina 330 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359218 Usefulness of non‐invasive test Gastropanel in order to improve the Protonic Pomp Inhibitors (PPIs) administration appropriateness in elderly population in Parma area. Emilia‐Romagna DI MARIO FRANCESCO Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Gastrointestinal Mucosal Pathobiology ‐ GMPB RF‐2013‐ 02359219 ß‐D‐GLUCAN DRIVEN EARLY DE‐ESCALATION OF ANTIFUNGAL THERAPY IN CRITICALLY ILL PATIENTS: AN INNOVATIVE ANTIFUNGAL STEWARDSHIP PROGRAM Emilia‐Romagna VIALE PIERLUIGI Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS RF‐2013‐ 02359233 Identification of novel diagnostic and therapeutical targets in the management of patients with polyps and colorectal carcinoma SAN RAFFAELE MILANO Testoni Pier Alberto Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME RF‐2013‐ 02359234 An integrative approach to the design of rational targeted REGINA ELENA therapeutics in cholangiocarcinoma Grazi Gian Luca Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP RF‐2013‐ 02359235 New analytical strategies to improve food safety: development of fast and high‐sensitive methods, based on powerful and innovative materials, to detect pathogenic bacteria and their toxins IZSME capuano federico Biomedica Veterinary Food Safety ‐ FOSA RF‐2013‐ 02359236 Dissecting RBL2/p130 role in apoptosis, and its interplay with the AKT pathway, to fully exploit its tumor suppressor potential therapeutically PASCALE Pentimalli Francesca Biomedica Oncology 1 ‐ Basic Translational Cancer Molecular Pathobiology ‐ CAMP RF‐2013‐ 02359237 Role of gut microbioma and circulatingRNA in celiac patients Lombardia Lanzini Alberto Biomedica Digestive, Kidney and Urological Systems Clinical, Integrative and Molecular Gastroenterology ‐ CIMG RF‐2013‐ 02359241 Patients and citizens involvement in Health Technology Assessment Agenzia per i Servizi Sanitari Regionali Lo Scalzo Alessandra Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02359244 Biotechnological reagents combined with plasmonic and nanomechanical sensors for improved foodborne viruses detection IZSLER PAVONI ENRICO Biomedica Instrumentation and Systems Development ‐ ISD Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Bioengineering Sciences and Technologies Classificazione 2° liv. Pagina 331 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA Classificazione 1 Liv. Classificazione 2° liv. RF‐2013‐ 02359245 A study designed to replicate the whole‐exome sequencing‐mediated identification of novel variants involved in inhibitor development in severe Italian Hemophilia A patients MAGGIORE Peyvandi Flora Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD RF‐2013‐ 02359247 CDCP1 as a therapeutic target in metastases of triple‐ negative breast cancer ISTITUTO TUMORI MILANO Tagliabue Elda Biomedica Oncology 1 ‐ Basic Translational Tumor Progression and Metastasis ‐ TPM2 RF‐2013‐ 02359248 Clinical and genetic predisposition to gliomas and spinal tumors in neurofibromatosis type 1. CARLO BESTA eoli marica Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroimmunology and Brain Tumors ‐ CNBT RF‐2013‐ 02359250 OsteoCHONdral tissue REGENeration by a novel anti‐ INflammatory bi‐phasic scaffold (CHONREGENIN) GALEAZZI Peretti Giuseppe Biomedica Musculoskeletal Tissue Engineering ‐ MTE RF‐2013‐ 02359251 Neo adjuvant systemic chemotherapy plus intra arterial chemotherapy plus external capacitive hyperthermia followed by percutaneous irreversible electroporation and than by adjuvant therapy in locally advanced pancreatic cancer: a phase 1‐2 clinical trial ONCOLOGICO DI BARI Gadaleta Cosmo Damiano Clinico‐ RF‐2013‐ 02359256 Adjunctive corticosteroid treatment in critically ill patients with septic shock. A multicenter randomised blinded placebo controlled trial of hydrocortisone in critically ill patients with septic shock SAN RAFFAELE MILANO BOVE RF‐2013‐ 02359258 Innovative therapy for precancerous skin lesions : improving efficacy and increasing patient compliance, while reducing side effects Emilia‐Romagna RF‐2013‐ 02359266 Development of new laboratory approaches to identify immunological markers in the ovine udder and milk during infection and vaccination against contagious agalactia. IZSSI P.I. Musculoskeletal, Oral and Skin Sciences Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC TIZIANA Biomedica Infectious Diseases and Microbiology Clinical Research and Field Studies of Infectious Diseases ‐ CRFS feliciani claudio Biomedica Oncology 2 ‐ Translational Clinical Developmental Therapeutics ‐ DT Loria Guido Ruggero Biomedica Veterinary Animal Health ‐ ANHE Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 332 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359271 Comparative approaches to the molecular immunopathogenesis of Paratubercolosis IZSLER Ricchi Matteo Biomedica Veterinary Animal Health ‐ ANHE RF‐2013‐ 02359272 Systems Medicine & Chronic Rhinosinusitis with Nasal Polyps: Host Genome and its Interactions with Microbiome and Environment SAN RAFFAELE MILANO Trimarchi matteo Biomedica Infectious Diseases and Microbiology Host Interactions with Bacterial Pathogens ‐ HIBP RF‐2013‐ 02359274 Prevention of obesity through prebiotic effect of plant derived insulin‐mimetic substances SAN RAFFAELE MILANO Terruzzi Ileana Marina Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Clinical and Integrative Diabetes and Obesity ‐ CIDO RF‐2013‐ 02359275 Neurobehavioral problems in autistic spectrum disorder patients undergoing pediatric dentistry care: an observational and experimental study aimed at an innovative, tailored approach in special‐needs patients Istituto Superiore di Sanita' Alleva Enrico Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02359278 Evaluation of patient preferences around the different cancer services dimensions: newevidences for improving service organisation. Piemonte LIBERO Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02359279 A randomized clinical trial to evaluate the efficacy of Horticultural Therapy Protocol (HTP) on behavioral disorders in people with mild to moderate Alzheimer¿s disease. Istituto Superiore di Sanita' Rosmini Francesco Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02359282 Environmental and allergic factors affecting the prevalence and the diagnostic‐therapeutic approaches of asthma in children MARIO NEGRI Clavenna Antonio Clinico‐ Population Sciences and assistenzial Epidemiology e Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions ‐ IRAP RF‐2013‐ 02359283 : RELATIONSHIP OF GLUCAGON‐LIKE PEPTIDE‐1 WITH DEPRESSION AND COGNITIVE DYSFUNCTION IN PATIENTS WITH TYPE 2 DIABETES. Toscana Mannucci Edoardo Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrative Physiology of Obesity and Diabetes ‐ IPOD RF‐2013‐ 02359284 Risks of Occupational exposure to Nanomaterials: an integrated approach to evaluate exposure and health effects at workplace INAIL Cavallo Delia Biomedica Bioengineering Sciences and Technologies Nanotechnology ‐ NANO CIUFFREDA Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 333 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359288 New Diagnostic and Therapeutic Approaches To Preeclampsia: Maternal Circulating Biomarkers for Early Diagnosis, Micronutrients Supplementation and placental‐derived molecular tools Against Placental Hypoxia, Oxidative Stress and Endothelial Damage. Piemonte TODROS TULLIA Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Pregnancy and Neonatology ‐ PN RF‐2013‐ 02359290 Sedation Practices in Intensive Care Evaluation: Early Goal Directed Sedation Compared with Standard Care in Mechanically Ventilated Patients in Intensive Care SAN RAFFAELE MILANO Cabrini Luca Biomedica Cardiovascular and Respiratory Sciences Lung Injury, Repair, and Remodeling ‐ LIRR RF‐2013‐ 02359294 IMPACT OF A RESCUE COURSE OF ANTENATAL CORTICOSTEROIDS ON DEVELOPING BRAIN: A RANDOMISED CONTROLLED TRIAL ON SHORT‐ TERM AND LONG‐TERM OUTCOMES Emilia‐Romagna RIZZO NICOLA Biomedica Brain Disorders and Clinical Neuroscience Developmental Brain Disorders ‐ DBD RF‐2013‐ 02359298 Determinants of healthy aging in the EPIC‐Italy cohort ISTITUTO TUMORI MILANO Pala Maria Valeria Clinico‐ Risk, Prevention and assistenzial Health Behavior e SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan ‐ TPM1 RF‐2013‐ 02359306 Modulation of visuospatial awareness during multi‐ tasking in right hemisphere stroke patients: towards novel behavioral and neurofunctional predictors of impairment and recovery of the attentional networks S.CAMILLO Zorzi Marco Biomedica Cognitive Neuroscience ‐ COG RF‐2013‐ 02359307 Implementation and evaluation of the Meeting Centers Support Programme for people with dementia and their carers (MCSP): cost effectiveness in Italy DON GNOCCHI Farina Elisabetta Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02359309 Toscana Novel diagnostic/prognostic perspectives of 18KDa‐ Translocator Protein (TSPO) measurement in an Alzheimer Disease (AD) mouse model: a microPET study. D'Agata Alberino Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02359317 THE EFFECT OF PRE‐TRANSPLANT GRAFT RECONDITIONING WITH MESENCHYMAL STROMAL CELLS IN EXPERIMENTAL KIDNEY TRANSPLANTATION Biomedica Digestive, Kidney and Urological Systems Cellular and Molecular Biology of the Kidney ‐ CMBK SAN MATTEO AREA P.I. DAL CANTON ANTONIO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Classificazione 1 Liv. Classificazione 2° liv. Integrative, Functional, and Cognitive Neuroscience Pagina 334 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359318 Development and validation of a production process for homologous serum eye drops and fibrin‐platelet gel preparation from umbilical cord blood. Veneto De Angeli Sergio Biomedica Vascular and Hematology Erythrocyte and Leukocyte Biology ‐ ELB RF‐2013‐ 02359319 Identification of new prognostic/diagnostic markers of Neuroblastoma: iPS cells ‐based study of Lamin A dysregulation MULTIMEDICA Rizzi Roberto Biomedica Genes, Genomes and Genetics Molecular Genetics ‐ MGA RF‐2013‐ 02359322 Protocol for the treatment of Critical Limb Ischemia no option therapy with bone marrow stem cell concentrate harvested with a point of care device Emilia‐Romagna Stella Andrea Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS RF‐2013‐ 02359323 PROTECTING THE HEALTH AND DEVELOPMENT OF INFANTS SINCE THE EARLY DAYS : HUMAN VERSUS COWS MILK Campania Raimondi Francesco Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Pregnancy and Neonatology ‐ PN RF‐2013‐ 02359324 A new approach for prevention of nosocomial infections: development of advanced protocols and guidelines for integrated surveillance procedures based on molecular monitoring of endoscopes and reusable devices. Campania SMERAGLIA RICCARDO Biomedica Infectious Diseases and Microbiology Small Business: Non‐ HIV Infectious Agent Detection/Diagnostic s, Food Safety, Sterilization/Disinfec tion and Bioremediation ‐ SBID RF‐2013‐ 02359325 Pharmacogenetic study on Busulfan and hepatic veno‐ occlusive disease in paediatric patients undergoing hematopoietic stem cell transplantation BURLO GAROFALO Rabusin Marco Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02359326 A multicenter study on the diagnosis, immune HUMANITAS pathogenesis and therapy of chronic inflammatory demyelinating polyrardiculoneuropathy (CIDP) and of its variants Nobile‐Orazio Eduardo Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroimmunology and Brain Tumors ‐ CNBT RF‐2013‐ 02359327 A randomized approach to define the best treatment strategy for prostate cancer patients with lymphnodal recurrence: personalized‐therapies or androgen deprivation therapy? Picchio Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC SAN RAFFAELE MILANO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Maria Classificazione 1 Liv. Classificazione 2° liv. Pagina 335 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359328 The exposome of soccer players: evaluation of potential health risks associated with exposure to Substances of Very High Concern (SVHC) identified in the framework of the REACH Regulation and to other chemicals of concern. RF‐2013‐ 02359333 Emilia‐Romagna A NOVEL INTEGRATED GENOMIC AND IMMUNOLOGICAL STRATEGY FOR THE THERAPY OF CHRONIC HEPATITIS B RF‐2013‐ 02359337 Evaluation of the anti‐tumor effects and mechanisms of antiretroviral drugs in cervical cancer: preclinical and human studies Istituto Superiore di Sanita' Sgadari RF‐2013‐ 02359338 Circulating Endothelial Progenitor Cells and Aquaporins as predictive biomarkers of onset and growth of hemangioblastomas and cysts in von Hippel‐Lindau disease. Emilia‐Romagna RF‐2013‐ 02359339 Assessment of the risk for consumers exposed to palytoxins contaminated seafood in the presence of Ostreopsis cf. ovata bloom along the Italian coasts RF‐2013‐ 02359348 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. rosa Biomedica Risk, Prevention and Health Behavior SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan ‐ TPM1 Carlo Biomedica Immunology Immunity and Host Defense ‐ IHD Cecilia Biomedica Oncology 2 ‐ Translational Clinical Basic Mechanisms of Cancer Therapeutics ‐ BMCT Giacomo Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS Istituto Superiore di Sanita' Testai Emanuela Biomedica Veterinary Food Safety ‐ FOSA Cell intrinsic and extrinsic mechanisms sustaining chemorefractoriness in Diffuse Large B‐Cell Lymphoma (DLBCL) and classical Hodgkin Lymphoma (cHL): implications for diagnosis and therapeutic targeting HUMANITAS LOCATI MASSIMO Biomedica Oncology 1 ‐ Basic Translational Tumor Microenvironment ‐ TME RF‐2013‐ 02359351 The role of 3TMRI‐HIFU in the periosteal neurolysis of the productive lytic bone metastates CROB CAMMAROTA ALDO Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Radiation Therapeutics and Biology ‐ RTB RF‐2013‐ 02359354 Innovative approach to HIFU treatments for health care costs reduction and patient compliance improvement. Sicilia Bartolotta Biomedica Computational modeling and sciences for biomedical and clinical applications ‐ ZRCM Istituto Superiore di Sanita' draisci Ferrari Pavesi Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Tommaso Vincenzo Surgical Sciences, Biomedical Imaging, and Bioengineering Pagina 336 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359359 Research, design, analysis, development, test and tuning Lazio of a web based informatic system to be used even on Tablet Android to support and coordinate all activities of inspection, monitoring and sampling In the field of occupational safety, building sites FIRICANO IRENE Biomedica Healthcare Delivery and Methodologies Health and Health Related Behavior of Individuals and Populations Fellowship ‐ F16 RF‐2013‐ 02359363 Mapping the multisensory nature of the primary visual and auditory cortices with intracranial EEG and fMRI bruzzone maria grazia Biomedica Integrative, Functional, and Cognitive Neuroscience Cognitive Neuroscience ‐ COG RF‐2013‐ 02359364 Evaluation of two different postpartum and post‐abortion Istituto Superiore di Sanita' Rota rubella vaccination protocols in a sample of Italian hospitals. Maria Cristina Biomedica Infectious Diseases and Microbiology Clinical Research and Field Studies of Infectious Diseases ‐ CRFS RF‐2013‐ 02359365 GENOTYPING OF POLYMORPHISM OF RS753482 eNOS‐ SAN RAFFAELE MILANO C IN A COHORT OF MEN AFFECTED BY ERECTILE DYSFUNCTION AND ANALYSIS OF ITS IMPACT ON THE RESPONSE TO THERAPY WITH PDE5‐I Salonia Andrea Clinico‐ Digestive, Kidney and assistenzial Urological Systems e Urologic and Kidney Development and Genitourinary Diseases ‐ UKGD RF‐2013‐ 02359366 Evaluating Atrial Fibrillation and Related Outcomes Using a Validated Healthcare Database. Effectiveness of New vs Old Anticoagulants and Physicians' Prescription Behavior. Abraha Iosief Clinico‐ Population Sciences and assistenzial Epidemiology e Cardiovascular and Sleep Epidemiology ‐ CASE RF‐2013‐ 02359367 Adaptive radiotherapy concomitant with chemotherapy SAN RAFFAELE MILANO in preoperative treatment of rectal adenocarcinoma. Dose finding and clinical efficacy of adaptive radiotherapy; assessment of radiologic, functional, and genetic parameters predicting pathologic complet Passoni Paolo Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC RF‐2013‐ 02359369 METABOLOMIC ANALYSIS IN HUMAN URINE TO IDENTIFY PROGNOSTIC BIOMARKERS OF PRETERM LABOR AND PRETERM PRELABOUR RUPTURE OF MEMBRANES. MELONI ALESSANDRA Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Pregnancy and Neonatology ‐ PN RF‐2013‐ 02359371 Characterization of multidrug resistant (MDR) Klebsiella IZSSI pneumoniae strains in Sicilian animals compared with clinical isolates Costa Antonella Biomedica Infectious Diseases and Microbiology Clinical Research and Field Studies of Infectious Diseases ‐ CRFS CARLO BESTA Umbria Sardegna Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Pagina 337 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359377 Effect of adapted physical activity (APA) training programs on exercise tolerance, cardio‐pulmonary functionality, muscle strength, symptoms, inflammatory cytokines response, quality of life in subjects affected by multiple sclerosis (MS). SANTA LUCIA Delussu Anna Sofia Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02359380 Early discharge and remote management of heart failure patient at "Policlinico Casilino" Lazio D'ESTE GIORGIO Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02359381 Addressing the pancreatic beta cells for the prevention and treatment of type 2 diabetes Toscana Marchetti Piero Biomedica Molecular and Cellular Endocrinology ‐ MCE RF‐2013‐ 02359388 Brain mapping in asleep conditions in the treatment of high grade gliomas in the language areas CARLO BESTA Legnani Federico Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Biomedical Imaging Technology ‐ BMIT RF‐2013‐ 02359390 MicroRNA: new markers for the diagnosis of occult hepatitis B Istituto Superiore di Sanita' Marcantonio Cinzia Biomedica Clinical Research and Field Studies of Infectious Diseases ‐ CRFS RF‐2013‐ 02359398 Mobile health‐care system for symptoms monitoring in patients with metastatic breast cancer receving targeted‐ terapy Abruzzo Giampiero Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC RF‐2013‐ 02359399 Integrated/tiered approach as a tool for evaluating Istituto Superiore di Sanita' Maranghi potential toxicity of nanomaterials of concern for human health. Identification of relevant biomarkers for immune, reproductive, endocrine and geno‐toxicity Francesca Biomedica Bioengineering Sciences and Technologies Nanotechnology ‐ NANO RF‐2013‐ 02359403 Anti‐biopharmaceutical immunization: evaluation of Toscana immunogenicity of biological agents in immunomediated diseases through the detection of anti‐drug antibodies, analysis of its clinical relevance and risk factors vultaggio alessandra Biomedica Immunology Hypersensitivity, Autoimmune, and Immune Porzio Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Endocrinology, Metabolism, Nutrition and Reproductive Sciences Infectious Diseases and Microbiology Pagina 338 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359404 SPALLANZANI Intensification with dolutegravir in patients who have a stably suppressed HIV‐1 viremia during boosted‐ritonavir protease inhibitor monotherapy (Dolutegravir Protease Inhibitor Monotherapy Intensification ‐ DOLPHIN Study) RF‐2013‐ 02359409 A multiparametric and risk based monitoring approach to support clinical decision in pediatric cardiac intensive care RF‐2013‐ 02359411 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Antinori Andrea Clinico‐ AIDS and Related Research assistenzial e AIDS Clinical Studies and Epidemiology ‐ ACE OSPEDALE BAMBINO GESU' Cogo Paola Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS THE TASTE OF BACTERIA : Identifying the TAS2R38 genotypic risk of recurrence of upper respiratory infections. Campania Leone Carlo Antonio Biomedica Host Interactions with Bacterial Pathogens ‐ HIBP RF‐2013‐ 02359412 Ketogenic diet in the treatment of child drug resistant epilepsies: a longitudinal multicenter study on metabolic factors and epigenetic predictors of efficacy and tolerability MONDINO Veggiotti Pierangelo Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Developmental Brain Disorders ‐ DBD RF‐2013‐ 02359413 Eracle: daring with emotions. Psychological support in the services of cancer patients and their families Sicilia DI PASQUALE ANGELA Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC RF‐2013‐ 02359414 Understanding the molecular bases of congenital heart defects: from gene discovery to molecular diagnosis OSPEDALE BAMBINO GESU' Digilio Maria Cristina Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD RF‐2013‐ 02359415 IDENTIFICATION OF GENETIC ALTERATIONS ASSOCIATED WITH SECOND MALIGNANT NEOPLASMS HUMANITAS SANTORO ARMANDO Biomedica Oncology 1 ‐ Basic Translational Cancer Genetics ‐ CG RF‐2013‐ 02359416 Integrating serum metabolomic, circulating microRNAs profiling and adrenomedullin levels in early screening of pancreatic carcinoma in new‐onset diabetes patients Lazio D'Angelo Francesco Antonio Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02359425 Development of pre‐operative investigation tools and surgical procedures for the treatment of movement disorders in childhood OSPEDALE BAMBINO GESU' Marras Carlo Efisio Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Infectious Diseases and Microbiology Developmental Brain Disorders ‐ DBD Pagina 339 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359426 THE IMPACT OF SONICATION ON INFECTION DIAGNOSIS AND TREATMENT. SAN MATTEO BENAZZO FRANCESCO Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS RF‐2013‐ 02359427 Cardiac dysfunction induced by tyrosine kinase inhibitors: from early diagnosis to therapy Sicilia siragusa sergio Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF RF‐2013‐ 02359428 Lung transthoracic US elastography imaging and contrast Sicilia imaging US: a comparisonaddressed to US‐guided biopsies of subpleural cancer Trovato Guglielmo Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC RF‐2013‐ 02359432 Sicilia Gender related comparisons of life habits, fertile life characteristics and advanced MRI parameters in multiple sclerosis Ragonese Paolo Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroimmunology and Brain Tumors ‐ CNBT RF‐2013‐ 02359440 Involvement of cytoskeleton proteins in mediating pulmonary neuroendocrine tumors clinical presentation and progression HUMANITAS Lania Andrea Gerardo Biomedica Antonio RF‐2013‐ 02359441 Randomized controlled study on the evaluation of rehabilitation treatments for mild cognitive impairment in patients with relapsing‐remitting and secondary progressive multiple sclerosis Istituto Scienze Neurologiche maffei monica Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02359442 sEMG descriptors of fatigue as outcome measures in facioscapulohumeral dystrophy: analysis of the effects of branched chain amino acid supplementation MAGGIORE Moggio Maurizio Gualtiero Clinico‐ Musculoskeletal, Oral and assistenzial Skin Sciences e Musculoskeletal Rehabilitation Sciences ‐ MRS RF‐2013‐ 02359443 Biological features ,role of biomarkers and extent of Emilia‐Romagna surgical resection in Right Colon Cancer: identification of a score of probability of local and metastatic spread for personalized surgery Anania Gabriele Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02359451 Transmissibility and clinical significance of Mycobacterium abscessus in patients with cystic fibrosis Cariani Lisa Biomedica Infectious Diseases and Microbiology Bacterial Pathogenesis ‐ BACP MAGGIORE Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Oncology 1 ‐ Basic Translational Tumor Progression and Metastasis ‐ TPM2 Pagina 340 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359453 Evaluation of monoamine oxidase A (MAO) as a target for treatment of Prostate Cancer. I.E.O. NOLE' FRANCO Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC RF‐2013‐ 02359454 Effects of maternal nutrition during pregnancy on fetal epigenetic profile: set up of a research infrastructure. MAGGIORE Bosari Silvano Biomedica Health and Health Related Behavior of Individuals and Populations Fellowship ‐ F16 RF‐2013‐ 02359456 New molecular deep‐sequencing approach for minimal residual disease detection in adult Acute Lymphoblastic Leukemia patients for risk stratification and treatment definition. Lombardia Rambaldi Alessandro Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02359463 Auditory surveillance: designing tools and protocols for an effective follow‐up after newborn hearing screening BURLO GAROFALO Orzan Eva Clinico‐ Integrative, Functional, assistenzial and Cognitive Neuroscience e Auditory System ‐ AUD RF‐2013‐ 02359470 MEDEA AN INNOVATIVE TECHNOLOGICAL MODEL FOR REHABILITATION OF CHILDREN WITH CEREBRAL PALSY: VIRTUAL REALITY (VR), VIDEO GAMES AND ON‐LINE TUTORING FOR COORDINATIVE TRAINING AND HOME CARE ASSISTANCE. EFFICACY AND COST AFFORDANCE TURCONI ANNA CARLA Clinico‐ Emerging Technologies and Neurotechnology ‐ assistenzial Training in Neurosciences NT e RF‐2013‐ 02359473 A medical devices submission template for the Italian context (TemplaIT) Agenzia per i Servizi Sanitari Regionali Cerbo Marina Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02359476 A molecularly based diagnostic and pharmacological approach to IgA nephropathy Lazio Gambaro Giovanni Biomedica Immunology Hypersensitivity, Autoimmune, and Immune RF‐2013‐ 02359488 Pentraxin 3: a novel biomarker for diagnosing prostate cancer. A validation study. Puglia Ranieri Elena Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Healthcare Delivery and Methodologies Pagina 341 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359490 Selective upregulation of KIR receptors by herpesvirus infection: a novel pathogenetic mechanism in multiple Sclerosis SAN RAFFAELE MILANO Malnati Mauro Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroimmunology and Brain Tumors ‐ CNBT RF‐2013‐ 02359494 PROSPECTIVE MULTICENTER STUDY ON RESEARCH AND VALIDATION OF PREDICTIVE BIOMARKERS OF RESPONSE TO AZACITIDINE IN PATIENTS WITH HIGH‐RISK MYELODYSPLASTIC SYNDROMES. Emilia‐Romagna Finelli Carlo Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02359495 Identification of early markers of Panic Disorder: a gene‐ by‐enviroment investigation in a developmental framework. SAN RAFFAELE MILANO Bellodi Laura Biomedica Brain Disorders and Clinical Neuroscience Pathophysiological Basis of Mental Disorders and Addictions ‐ PMDA RF‐2013‐ 02359499 ROLE OF NGF IN CHRONIC ALLOGRAFT NEPHROPATY Calabria Bonofiglio Renzo Biomedica Digestive, Kidney and Urological Systems Pathobiology of Kidney Disease ‐ PBKD RF‐2013‐ 02359503 Ischemic Preconditioning and the vascular response to ischemia in chronic kidney disease (CKD) patients (PROTECT‐CKD) Calabria Panuccio Vincenzo Antonio Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS RF‐2013‐ 02359515 New strategies for diagnostic, therapeutic and clinical care in Infectious and immunological diseases OSPEDALE BAMBINO GESU' Fiocchi Alessandro Biomedica Immunology Hypersensitivity, Autoimmune, and Immune RF‐2013‐ 02359516 Influenza pathways: release and exposure assessment to identify the virus maintenance strategies IZSPLV MAURELLA CRISTIANA Biomedica Veterinary Animal Health ‐ ANHE RF‐2013‐ 02359518 Improvement of diagnostic accuracy of FNA and brushing citology by FISH technique and K‐ras mutation analysis in patients with suspected pancreato‐biliary malignancies Friuli‐Venezia Giulia Bulajic Milutin Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e RF‐2013‐ 02359519 Role of GluD1 in Rett syndrome: studies in a murine model and human iPS cells MARIO NEGRI Invernizzi Roberto William Biomedica Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Genes, Genomes and Genetics Classificazione 2° liv. Cancer Biomarkers ‐ CBSS Therapeutic Approaches to Genetic Diseases ‐ TAG Pagina 342 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359523 A Knowledge‐Translation Platform for measuring rehabilitation outcomes and cost for patients in care pathways Friuli‐Venezia Giulia Saccavini Marsilio Clinico‐ Biobehavioral and assistenzial Behavioral Processes e Motor Function, Speech and Rehabilitation ‐ MFSR RF‐2013‐ 02359526 A research to improve the predictability in the mammography screening protocol Sicilia BENNICI ELIO Biomedica Computational modeling and sciences for biomedical and clinical applications ‐ ZRCM RF‐2013‐ 02359527 GENOTYPE‐PHENOTYPE CORRELATION FOR MAGNETIC RESONANCE IMAGING FEATURES OF MOWAT‐WILSON SYNDROME WITH ZEB2 MUTATION/DELETION; A NEW INTERNATIONAL DATABASE AND FUTURE DISCOVERIES OF THE ROLE OF THE GENE ZEB2 IN THE DEVELOPMENT OF THE HUMAN BRAIN ARCISPEDALE garavelli livia Clinico‐ Biobehavioral and assistenzial Behavioral Processes e Child Psychopathology and Developmental Disabilities ‐ CPDD RF‐2013‐ 02359528 RISK FACTORS FOR INVASIVE CANDIDIASIS IN INTERNAL MEDICINE AND GERIATRIC UNITS Puglia Serviddio Gaetano Clinico‐ Infectious Diseases and assistenzial Microbiology e Clinical Research and Field Studies of Infectious Diseases ‐ CRFS RF‐2013‐ 02359533 Is remote memory impairment in amnestic Mild Cognitive Impairment a predictor of conversion to Alzheimer's dementia? CARLO BESTA Tiraboschi Pietro Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02359534 OSPEDALE BAMBINO Evaluation of neonatal feeding on gut microbiota shaping: the nutritional value of milks added by bioactive GESU' molecules Putignani Lorenza Biomedica Integrative Nutrition and Metabolic Processes ‐ INMP RF‐2013‐ 02359537 Lifestyles, risk factors, and emerging biomarkers for the prediction of chronic non‐communicable diseases in the general adult population Luigi Clinico‐ Risk, Prevention and assistenzial Health Behavior e Istituto Superiore di Sanita' Palmieri Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Surgical Sciences, Biomedical Imaging, and Bioengineering Endocrinology, Metabolism, Nutrition and Reproductive Sciences SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan ‐ TPM1 Pagina 343 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359540 Sleep in Subjective Memory Impairment (SMI) as a pre‐ NEUROMED clinical stage of Alzheimer Disease: a neuroimaging study Grammaldo Liliana graciela Biomedica RF‐2013‐ 02359543 Cardiovascular diseases and impact of comorbid respiratory diseases (CADICORD) Umbria Reboldi Gianpaolo Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS RF‐2013‐ 02359546 Genome‐wide association study on Follicular lymphoma ONCOLOGICO DI BARI Guarini Attilio Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02359552 Effects of different nutritional supports on muscular and metabolic outcomes in sarcopenic and pre‐sarcopenic patients with type 2 diabetes mellitus as add on to neuromuscular training pre‐ Total Joint Replacement Piemonte Broglio Fabio Clinico‐ Endocrinology, assistenzial Metabolism, Nutrition and e Reproductive Sciences Integrative Nutrition and Metabolic Processes ‐ INMP RF‐2013‐ 02359554 Development of a model of cardiac surveillance for cancer patients candidates to molecular targeted agents therapies. Campania Pepe Stefano Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC RF‐2013‐ 02359558 GENetic susceptibility, Thrombin generation and whole Toscana blood viscoelasticitY assays: a new integrative theranostic approach for haemostasis management of PEdiatric patients with congenital disease (GENoTYPE) Botto Nicoletta Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS RF‐2013‐ 02359559 Food safety in children nutrition. Exposure of young Istituto Superiore di Sanita' milana children to chemicals migrated from tableware into foods: extensive study on migration, risk characterization and risk assessment . maria rosaria Biomedica SBIR/STTR: Risk Prevention and Health Behavior across the Lifespan ‐ TPM1 RF‐2013‐ 02359560 Monitoring infection in complex wounds in pediatric patients. New strategies and model for diagnostic, therapeutic and clinical care for prevention of infection sergio Clinico‐ Healthcare Delivery and assistenzial Methodologies e OSPEDALE BAMBINO GESU' bella Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Brain Disorders and Clinical Neuroscience Risk, Prevention and Health Behavior Clinical Neuroscience and Neurodegeneration ‐ CNN Nursing Science: Children and Families ‐ NSCF Pagina 344 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359569 Falls Prevention in hospitals and long‐term care through Liguria intelligent video surveillance and monitoring of fall‐ related behavioral patterns. RF‐2013‐ 02359572 Evaluation of cognitive impairment in patients with severe stenosis of the extracranial carotid arteries: beneficial effects of carotid artery stenting (CAS) RF‐2013‐ 02359576 The efficacy of treatments of peri‐implant diseases on oral health RF‐2013‐ 02359577 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Cardinale Francesco Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD Campania Rubino Paolo Biomedica Cardiovascular and Respiratory Sciences Clinical and Integrative Cardiovascular Sciences ‐ CICS SAN RAFFAELE MILANO Gherlone Enrico Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering Surgery, Anesthesiology, and Trauma ‐ SAT IDENTIFICATION OF NEW STRATEGIES TO IMPROVE Sicilia THE OUTCOME OF TRAUMATICBRAIN INJURY AND BRAIN ISCHEMIA: PRECLINICAL AND CLINICAL STUDIES ON NEWTARGETS AND ALREADY CLINICALLY AVAILABLE DRUGS Cuzzocrea Salvatore Biomedica Brain Disorders and Clinical Neuroscience Brain Injury and Neurovascular Pathologies ‐ BINP RF‐2013‐ 02359578 Estrogen‐dependent M1/M2 macrophage balance as a novel cardiovascular risk biomarker in relation to hormonal status and pathological amenorrhea in fertile women Veneto Scaroni Carla Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Endocrinology, Metabolism, Nutrition and Reproductive Sciences (EMNR) Integrated Review Group Fellowship Panel ‐ F06 RF‐2013‐ 02359580 PREVENTION OF REPEATED FIRST TRIMESTER VOLUNTARY ABORTION AMONG WOMEN WITH LOW CONTRACEPTIVE COMPLIANCE IMPROVES REPRODUCTIVE HEALTH AND REDUCES SOCIAL AND HOSPITAL COSTS Sicilia GIAMBANCO LAURA Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02359581 Virtual surgery to optimize the operative procedure and SAN DONATO improve the outcome in heart failure patients undergoing surgical reshaping of the left ventricle. Castelvecchio Serenella Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Bioengineering, Technology, and Surgical Sciences ‐ BTSS Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 345 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359584 Transcriptional regulatory networks in multiple sclerosis SAN RAFFAELE MILANO Farina Cinthia Biomedica RF‐2013‐ 02359585 Cognition and movement: behavioural and brain responses to a mixed cognitive and motor training in individuals with Parkinson's disease SANTA LUCIA Costa Alberto Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02359589 Epigenomics of paediatric multiple sclerosis Sicilia Grimaldi Luigi Biomedica Genomics, Computational Biology and Technology ‐ GCAT RF‐2013‐ 02359591 Improving clinical care, optimizing the research network CARLO BESTA for neurological patients: a Novel ORganizational MAtrix (NORMA). Cornelio Ferdinando Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02359592 The complement and coagulation systems: contribution to ischemia and microthrombosis in subarachnoid hemorrhage MAGGIORE Stocchetti Nino Biomedica Brain Disorders and Clinical Neuroscience Brain Injury and Neurovascular Pathologies ‐ BINP RF‐2013‐ 02359594 Vitamin E, miRNA and inflammation: a tunable network in Alzheimer's disease. Umbria Mecocci Patrizia Biomedica Brain Disorders and Clinical Neuroscience Clinical Neuroscience and Neurodegeneration ‐ CNN RF‐2013‐ 02359596 Research project for identification and evaluation of a new technical and organizational model able to ensure compliance with suspension time after slaughter in livestock in terms of Pharmacosurveillance, using a system developed in web technology and hig Lazio sciscione umberto Biomedica Veterinary Food Safety ‐ FOSA RF‐2013‐ 02359598 Studio multicentrico osservazionale sull'epidemiologia e l'outcome dell'arresto cardiaco in Italia. Effetti dell'implementazione di una rilevazione sistematica sull'esito. Emilia‐Romagna Cerchiari Erga Laura Errica Biomedica Healthcare Delivery and Methodologies Health Services Organization and Delivery ‐ HSOD Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Genes, Genomes and Genetics Genes, Genomes and Genetics Classificazione 2° liv. Genomics, Computational Biology and Technology ‐ GCAT Pagina 346 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359601 Monitoring and biofeedback for posture analysis on the workplace Istituto Superiore di Sanita' Morelli RF‐2013‐ 02359602 Comparison between hospital admission and early discharge from the emergency department of nursing‐ home dwelling older people diagnosed with pneumonia: a randomized clinical trial Toscana RF‐2013‐ 02359604 Population based epidemiology of early acquired disabilities: to qualify and quantify the unmet care needs of disabled individuals, to explore the implementation of targeted and innovative intervention. Abruzzo RF‐2013‐ 02359606 Honey bees as a sentinel species for PAHs environmental IZSVE contamination RF‐2013‐ 02359608 Evaluation of diagnostic accuracy in interpretation of screening mammograms: development of advanced dedicated software RF‐2013‐ 02359612 AREA P.I. Classificazione 1 Liv. Sandra Biomedica Monzani Fabio Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD ZULLI FILIPPO Clinico‐ Population Sciences and assistenzial Epidemiology e Social Sciences and Population Studies ‐ SSPS Mutinelli Franco Biomedica Food Safety ‐ FOSA PANIZZA PIETRO Clinico‐ Risk, Prevention and assistenzial Health Behavior e Risk, Prevention and Intervention for Addictions ‐ RPIA Reducing overweight and obesity in patients as a strategy Lazio to improve disease activity and severity and to reduce the need for biological drugs in chronic inflammatory rheumatic diseases. Gremese Elisa Clinico‐ Musculoskeletal, Oral and assistenzial Skin Sciences e Arthritis, Connective Tissue and Skin ‐ ACTS RF‐2013‐ 02359616 Neonatal cardioplegia project (NECAP): investigations on Emilia‐Romagna protection of ischemic immature hearts. Angeli Emanuela Biomedica Myocardial Ischemia and Metabolism ‐ MIM RF‐2013‐ 02359621 Clinical and Experimental Pathway to Vitiligo Management SAN GALLICANO LEONE GIOVANNI Clinico‐ Musculoskeletal, Oral and assistenzial Skin Sciences e Arthritis, Connective Tissue and Skin ‐ ACTS RF‐2013‐ 02359622 Risk assessment from tattoos and laser tattoo removal: evaluation of dermal toxicity, cell toxicity and gene toxicity of nano‐ and micro‐substances SAN GALLICANO Cristaudo Antonio Biomedica Risk, Prevention and Intervention for Addictions ‐ RPIA ISTITUTO TUMORI MILANO Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Bioengineering Sciences and Technologies Classificazione 2° liv. Veterinary Cardiovascular and Respiratory Sciences Risk, Prevention and Health Behavior Instrumentation and Systems Development ‐ ISD Pagina 347 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359625 Study on the cerebellar role in Pathological Gambling: an SANTA LUCIA insight into the neurobiological bases of the Impulse Control Disorders. Leggio Maria Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Neural Basis of Psychopathology, Addictions and Sleep Disorders ‐ NPAS RF‐2013‐ 02359627 Exploring the link between antenatal maternal depression and infants¿ bio‐behavioral regulation Frigerio Alessandra Biomedica Biobehavioral and Behavioral Processes Biobehavioral Mechanisms of Emotion, Stress and Health ‐ MESH RF‐2013‐ 02359629 Liquid biopsies to detect microscopic residual disease and Istituto Scientifico monitor its evolution after surgery for early breast cancer Romagnolo ROCCA ANDREA Biomedica Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS RF‐2013‐ 02359631 Development of a dose report software and its application Sicilia in each radiology department of Sicilian Public Hospitals Brancatelli Giuseppe Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Biomedical Imaging Technology ‐ BMIT RF‐2013‐ 02359632 Detection of predictive markers for therapeutic stratification of salivary glands tumors PASCALE LONGO FRANCESCO Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02359639 Gene expression profiling and proteomic analysis on tendons and single muscle fibers from children with Cerebral Palsy HUMANITAS portinaro nicola Biomedica Musculoskeletal, Oral and Skin Sciences Skeletal Biology Structure and Regeneration ‐ SBSR RF‐2013‐ 02359640 Association between childhood exposure to phthalates and bisphenol‐A, subclinical hypothyroidism and cardiometabolic risk OSPEDALE BAMBINO GESU' Cianfarani Stefano Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Endocrinology, Metabolism, Nutrition and Reproductive Sciences (EMNR) Integrated Review Group Fellowship Panel ‐ F06 RF‐2013‐ 02359642 Clinical correlates of cerebral amyloid burden in subjects SANTA LUCIA with neurodegenerative cognitive decline Cravello Luca Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e MEDEA Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Clinical Neuroscience and Neurodegeneration ‐ CNN Pagina 348 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA RF‐2013‐ 02359643 NOVEL AND SELECTIVE ANTITUMOR STRATEGIES FOR THE TREATMENT OF MALIGNANT MELANOMA ISTITUTO DERMOPATICO DELL'IMMACOLATA Lacal Pedro Miguel Biomedica Oncology 2 ‐ Translational Clinical Developmental Therapeutics ‐ DT RF‐2013‐ 02359644 EPINEPHRINE (ADRENALINE) REFORMULATION IN IMPROVED STABILITY DRUG DELIVERY SYSTEMS, FOR INNOVATIVE USE IN EMERGENCY SITUATIONS SAN MATTEO Imberti Roberto Biomedica Bioengineering Sciences and Technologies Biomaterials and Biointerfaces ‐ BMBI RF‐2013‐ 02359645 Metabolic reprogramming as therapeutic strategy to SAN RAFFAELE PISANA ameliorate skeletal muscle tissue engineering procedures. Gargioli Cesare Biomedica Musculoskeletal, Oral and Skin Sciences Musculoskeletal Tissue Engineering ‐ MTE RF‐2013‐ 02359647 High density of tumor‐associated macrophages (TAM) predicts the responsiveness of stage III colorectal cancer (CRC) to adjuvant chemotherapy. HUMANITAS LAGHI Oncology 2 ‐ Translational LUIGI ANDREA Clinico‐ assistenzial Clinical GIUSEPPE RF‐2013‐ 02359661 A pilot study of pretherapeutic sorafenib evaluation in primary cells, and in tumor xenografts, in papillary aggressive thyroid cancer. Toscana Miccoli Paolo Biomedica RF‐2013‐ 02359671 Quality of life in persons with severe traumatic brain injury and their caregivers SANTA LUCIA Bivona Umberto Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Brain Injury and Neurovascular Pathologies ‐ BINP RF‐2013‐ 02359674 New Computational Tools for Patient Safety in IntraOperative Electron Radiation Therapy Umbria Maranzano Ernesto Biomedica Oncology 2 ‐ Translational Clinical Small Business [SBIR/STTR] Radiation Therapy and Biology ‐SETA] RF‐2013‐ 02359675 Strength‐aerobic training to treat peripheral arterial disease: a new approach to contrast atherosclerosis and disability. Veneto De Marchi Sergio Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Clinical and Integrative Cardiovascular Sciences ‐ CICS RF‐2013‐ 02359680 PREDICTION OF HIGH GRADE GLIOMAS GENOMIC SUBTYPES BY MEANS OF ADVANCED MAGNETIC RESONANCE IMAGING BIOMARKERS CASA SOLLIEVO SOFFERENZA Popolizio Teresa Biomedica Cancer Biomarkers ‐ CBSS P.I. Classificazione 1 Liv. Classificazione 2° liv. Clinical Oncology ‐ CONC e Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Oncology 2 ‐ Translational Clinical Oncology 2 ‐ Translational Clinical Oncology 2 ‐ Translational Clinical Clinical Oncology ‐ CONC Pagina 349 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA RF‐2013‐ 02359682 Exploitation of ctDNA (liquid biopsy) for therapeutic decision in mCRC Istituto Oncologico Candiolo Leone Francesco Biomedica RF‐2013‐ 02359685 A new diagnostic tool based on Raman spectroscopy for fast, easy and cheap determination of plasmatic concentrations of antiepileptic drugs CARLO BESTA Ciusani Emilio Clinico‐ Bioengineering Sciences assistenzial and Technologies e Instrumentation and Systems Development ‐ ISD RF‐2013‐ 02359686 Remote ischemic preconditiong in patients undergoing non‐cardiac surgery. A multicenter randomized trial. SAN RAFFAELE MILANO Landoni Giovanni Clinico‐ Cardiovascular and assistenzial Respiratory Sciences e Myocardial Ischemia and Metabolism ‐ MIM RF‐2013‐ 02359692 Towards precision medicine for patients with biliary tract ISTITUTO TUMORI MILANO cancers: tailored treatments based on the mutational profile detected on tumor lesions and monitored in liquid biopsies (circulating tumor cells, CTC, and circulating tumor DNA, ctDNA) Daidone Maria Grazia Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02359695 Fatty acids in breast milk and perinatal exposures to Friuli‐Venezia Giulia metals and organic compounds may predict child neuropsychological scores at 18 months in a mother‐child cohort of 900 BARBONE FABIO Clinico‐ Population Sciences and assistenzial Epidemiology e Neurological, Aging and Musculoskeletal Epidemiology ‐ NAME RF‐2013‐ 02359697 From nociception to pain in disorders of consciousness (DoC) following severe acquired brain injury (ABI) SANTA LUCIA Buzzi Maria Gabriella Clinico‐ RF‐2013‐ 02359699 Building a putative universal model for immune modulation of virus‐related tumors: the role of cell therapy in head and neck cancer SAN MATTEO Basso RF‐2013‐ 02359703 Genetic and environmental determinants of left ventricular mass and arterial function: a twin study Umbria RF‐2013‐ 02359704 Elucidating molecular and functional interactions between steroids and histone deacetylase inhibitors in the treatment of neuromuscular disorders SANTA LUCIA P.I. Classificazione 1 Liv. Classificazione 2° liv. Oncology 2 ‐ Translational Clinical Cancer Biomarkers ‐ CBSS Brain Disorders and assistenzial Clinical Neuroscience e Brain Injury and Neurovascular Pathologies ‐ BINP Sabrina Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Immunopathology and Immunotherapy ‐ CII Pucci Giacomo Biomedica Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF Puri Pier Lorenzo Biomedica Musculoskeletal, Oral and Skin Sciences Skeletal Muscle Biology and Exercise Physiology ‐ SMEP Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Pagina 350 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359708 Mechanical ventilation guided by oesophageal pressure in Piemonte severe burn patients. RF‐2013‐ 02359713 Improving Prognostic Accuracy in Severe Traumatic Brain Injury using advanced neuroimaging methods and multivariate prognostic modeling RF‐2013‐ 02359717 Volatile Organic Compounds analysis for early‐stage lung ARCISPEDALE cancer diagnosis. RF‐2013‐ 02359718 Early verticalization using ERIGO may improve functional and cognitive outcome following Severe Acquired Brain Injury RF‐2013‐ 02359719 Pediatric epilepsy: clinical and genomic diagnosis. Application of ILAE 2013 treatment guidelines and validation of the results in pediatric epileptic patients. RF‐2013‐ 02359725 AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Berardino Maurizio Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Surgery, Anesthesiology, and Trauma ‐ SAT Magnoni Sandra Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Brain Injury and Neurovascular Pathologies ‐ BINP Lococo Filippo Biomedica Cancer Biomarkers ‐ CBSS NEUROLESI Bramanti Placido Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Brain Injury and Neurovascular Pathologies ‐ BINP Sicilia Pavone Piero Biomedica Acute Neural Injury and Epilepsy ‐ ANIE Multicenter, open, randomized, prospective study for the Toscana evaluation of safety and efficacy of normothermic machine perfusion for organ preservation (Metra®) in liver transplantation De Simone Paolo Clinico‐ Surgical Sciences, assistenzial Biomedical Imaging, and e Bioengineering Surgery, Anesthesiology, and Trauma ‐ SAT RF‐2013‐ 02359727 Effects on brain excitability of antibodies derived from epileptogenic autoimmune encephalitis CARLO BESTA Librizzi Laura Biomedica Brain Disorders and Clinical Neuroscience Acute Neural Injury and Epilepsy ‐ ANIE RF‐2013‐ 02359730 Mesenchimal stem cell‐derived extracellular vesicles as pharmaceutical tool for the treatment and prevention of epilepsy due to brain inflammation. OSPEDALE BAMBINO GESU' Vigevano Federico Biomedica Brain Disorders and Clinical Neuroscience Acute Neural Injury and Epilepsy ‐ ANIE RF‐2013‐ 02359735 IDENTIFICATION OF A CIRCULATING microRNAs SIGNATURE ABLE TO PREDICT RESPONSE TO NEOADJUVANT CHEMOTHERAPY IN ADVANCED OVARIAN CANCER Umbria Fagotti Anna Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e MAGGIORE Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Oncology 2 ‐ Translational Clinical Brain Disorders and Clinical Neuroscience Cancer Biomarkers ‐ CBSS Pagina 351 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359743 A study to improve removable denture adhesion with oral Piemonte mucosa: from the molecular basis to translational applications CERUTI PAOLA Biomedica RF‐2013‐ 02359745 Give screening a chance SAN MATTEO Brunetti Enrico Clinico‐ AIDS and Related Research assistenzial e AIDS Clinical Studies and Epidemiology ‐ ACE RF‐2013‐ 02359752 Epileptic seizures prediction through nonlinear dynamic analysis of EEG signals Sardegna Tamburini Giorgio Biomedica Acute Neural Injury and Epilepsy ‐ ANIE RF‐2013‐ 02359757 Brain and Heart (BraHe): Clinical evidences and Friuli‐Venezia Giulia biomarkers that correlate with cardiac and brain integrity or with disease. A population‐based study in the Centenarians in Trieste to predict successful aging. Di Lenarda Andrea Clinico‐ Biology of Development assistenzial and Aging e Aging Systems and Geriatrics ‐ ASG RF‐2013‐ 02359766 OSPEDALE BAMBINO The new implementation of EUnetHTA Core Model by integrating the Analytic Hierarchy Process: a validation of GESU' this methodology used in health technology assessment for supporting health care decision‐making and its application for driving the process of ad Derrico Pietro Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02359767 Human Ewing Sarcoma Family Tumor (ESFT) Revisited From Cancer Stem Cells (CSCs) tothe Epigenetic Regulation: cross‐talk between ncRNA and DNA methylation Lombardia Parafioriti Antonina Biomedica Oncology 1 ‐ Basic Translational Tumor Cell Biology ‐ TCB RF‐2013‐ 02359769 Development of miniaturized assays for the timely diagnosis of rare diseases Piemonte ROCCATELLO DARIO Biomedica Musculoskeletal, Oral and Skin Sciences Arthritis, Connective Tissue and Skin ‐ ACTS RF‐2013‐ 02359770 Recognition of a specific metabolic fingerprint of diabetic Sardegna cardiomyopathy, in order to clarify its pathophysiology, delay clinical manifestations of disease and improve the treatment Cadeddu Dessalvi Biomedica Cardiovascular and Respiratory Sciences Cardiac Contractility, Hypertrophy, and Failure ‐ CCHF Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Christian Classificazione 1 Liv. Classificazione 2° liv. Musculoskeletal, Oral and Skin Sciences Brain Disorders and Clinical Neuroscience Oral, Dental and Craniofacial Sciences ‐ ODCS Pagina 352 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359778 Research project on Colony Collapse Disorder on apiaries Lazio based on the storage into a single regional database of all results of sampling and information registries, health care and geo‐referenced positions, using web technologies and accessed even by tabl CIPOLLONE BRUNO Biomedica RF‐2013‐ 02359782 Ticagrelor vs. aspirin for prevention of cardiovascular events in aspirin‐treated patients with stroke or TIA. Umbria Paciaroni Maurizio Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Brain Injury and Neurovascular Pathologies ‐ BINP RF‐2013‐ 02359785 Molecular mechanisms mediating metastasis in renal angiomyolipoma and lymphangioleiomyomatosis formation: possible clues for identification of new pharmacological treatments Piemonte Porpiglia Francesco Biomedica Digestive, Kidney and Urological Systems Cellular and Molecular Biology of the Kidney ‐ CMBK RF‐2013‐ 02359788 Study of gene expression of the major allergens produced IZSLT by Anisakis sensu lato for risk assessment in fishery products of greatest commercial interest along Tyrrhenian coast Fichi Gianluca Biomedica Veterinary Food Safety ‐ FOSA RF‐2013‐ 02359789 Evaluation of the role of pathogens and environmental factors in determining Unusual Mortality Events (UMEs) of cetaceans in the Mediterranean, and development of a UMEs predictive model IZSPLV Mignone Walter Biomedica Veterinary Animal Health ‐ ANHE RF‐2013‐ 02359792 Impact of Telemedicine in the management of very elderly patients affected by severe chronic heart failure: clinical outcomes, economic and quality of life analysis I.N.R.C.A. Antonicelli Roberto Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02359794 This study aims to investigate the bioavailability, efficacy OSPEDALE BAMBINO and safety of pediatric‐friendly formulation not GESU' commercially available, centrally prepared by the Hospital Pharmacy Corsetti Tiziana Clinico‐ Bioengineering Sciences assistenzial and Technologies e Gene and Drug Delivery Systems ‐ GDD RF‐2013‐ 02359797 Virtual Reality Simulator and Computer Guiding System for endoscopic and robotic platforms Forgione Antonello Biomedica Biomedical Computing and Health Informatics ‐ BCHI Lombardia Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Veterinary Healthcare Delivery and Methodologies Classificazione 2° liv. Animal Health ‐ ANHE Pagina 353 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO RF‐2013‐ 02359799 INCIDENCE OF OSTEONECROSIS OF THE JAW IN PATIENTS IN THERAPY WITH DENOSUMAB AND ANTIANGIOGENIC DRUGS: AN OBSERVATIONAL STUDY RF‐2013‐ 02359804 DESTINATARIO ISTITUZIONALE AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. forni franco Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Basic Mechanisms of Cancer Therapeutics ‐ BMCT Novel biomarkers of recurrence and druggable pathways Umbria to prevent tumor relapse inearly stage non‐small cell lung cancer (NSCLC) patients Crinò Lucio Clinico‐ Oncology 1 ‐ Basic assistenzial Translational e Tumor Microenvironment ‐ TME RF‐2013‐ 02359805 Performance of universal Lynch Syndrome screening ISTITUTO TUMORI using Mismatch Repair (MMR) Immunohistochemical test MILANO Sala Paola Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Cancer Biomarkers ‐ CBSS RF‐2013‐ 02359811 Effectiveness and cost/effective solutions for non self‐ sufficient people SANTA LUCIA salvia antonino Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e Brain Injury and Neurovascular Pathologies ‐ BINP RF‐2013‐ 02359814 Targeting macrophage polarization to overcome trabectedin resistance in myxoid liposarcoma. Lazio Vincenzi Bruno Biomedica Tumor Microenvironment ‐ TME RF‐2013‐ 02359815 Health Technology Assessment of adverse drug reactions: Lazio clinical, economical and organizational impact in a regional health system Marchetti Marco Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02359816 Looking for spontaneous prion diseases in wild‐type bank Istituto Superiore di Sanita' Nonno voles: a new animal model for sporadic, age related, neurodegenerative disorders Romolo Biomedica Brain Disorders and Clinical Neuroscience Cell Death in Neurodegeneration ‐ CDIN RF‐2013‐ 02359820 One Health Approach for Listeriosis: integration of the existing laboratory surveillance and control activities in the medical and food/veterinary sectors Veterinary Food Safety ‐ FOSA RF‐2013‐ 02359822 Development and institution of a rare cancers network in Abruzzo the "Regione Abruzzo" Natoli Clara Clinico‐ Population Sciences and assistenzial Epidemiology e Epidemiology of Cancer ‐ EPIC RF‐2013‐ 02359826 MULTI‐MODAL CHARACTERISATION OF CORTICO SPINAL TRACT LESIONS Rabuffetti Marco Biomedica Sensorimotor Integration ‐ SMI SAN MATTEO Istituto Superiore di Sanita' Gianfranceschi Monica Virginia Biomedica DON GNOCCHI Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Oncology 1 ‐ Basic Translational Integrative, Functional, and Cognitive Neuroscience Pagina 354 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359828 Biosafety in shellfish farming: study of emerging zoonoses IZSSA and application of an integrated model for biological risk management in livestock production, food security and environmental assessment in supply chains Virgilio Sebastiano Biomedica Veterinary Food Safety ‐ FOSA RF‐2013‐ 02359829 Tissue‐engineered gut as a novel model to study the mechanisms of Crohn¿s disease intestinal fibrosis Di Sabatino Antonio Biomedica Digestive, Kidney and Urological Systems Gastrointestinal Mucosal Pathobiology ‐ GMPB RF‐2013‐ 02359837 Creation of a new next‐generation panel for the diagnosis Associazione Oasi Maria SS Scuderi of Mitochondrial disorders with neuromuscular phenotype Carmela Biomedica Genes, Genomes and Genetics Genetics of Health and Disease ‐ GHD RF‐2013‐ 02359840 UltraSound, Contrast Enhanced UltraSound (CEUS) and CARLO BESTA 5‐aminolevulinic acid (5‐ALA) in tumour detection at the border of high grade gliomas: A prospective study based on a histopathological assessment. DiMeco Francesco Clinico‐ Oncology 2 ‐ Translational assistenzial Clinical e Clinical Oncology ‐ CONC RF‐2013‐ 02359842 BIOENGINEERING OF A NOVEL CORNEAL DEVICE COLONIZED BY AUTOLOGOUS CELLS FOR TREATMENT OF DEEP CORNEAL PATHOLOGIES SAN RAFFAELE MILANO Paganoni Giorgio Alessandro Biomedica Bioengineering, Technology, and Surgical Sciences ‐ BTSS RF‐2013‐ 02359844 Health‐related quality of life in children with Neurofibromatosis 1: a nation‐wide survey project on determining factors CARLO BESTA Saletti Veronica Clinico‐ Healthcare Delivery and assistenzial Methodologies e Health Services Organization and Delivery ‐ HSOD RF‐2013‐ 02359846 Efficacy and safety of an innovative herbal treatment on an ancient disease: the coxarthrosis Toscana FIRENZUOLI FABIO Clinico‐ Musculoskeletal, Oral and assistenzial Skin Sciences e Arthritis, Connective Tissue and Skin ‐ ACTS RF‐2013‐ 02359847 Constitution of an e‐infrastructure for advanced services in Public Health Istituto Superiore di Sanita' CACCIA BARBARA Biomedica Biomedical Computing and Health Informatics ‐ BCHI RF‐2013‐ 02359852 In vivo molecular and imaging predictors of dementia in parkinsonism Toscana Duccio Clinico‐ Brain Disorders and assistenzial Clinical Neuroscience e SAN MATTEO Volterrani Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete AREA P.I. Classificazione 1 Liv. Surgical Sciences, Biomedical Imaging, and Bioengineering Healthcare Delivery and Methodologies Classificazione 2° liv. Clinical Neuroscience and Neurodegeneration ‐ CNN Pagina 355 di 356 BANDO 2013 RICERCA FINALIZZATA ‐ Elenco Progetti Presentati CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2013‐ 02359863 SAN MATTEO Involvement of gut endothelial barrier modifications in celiac disease‐associated hypertransaminasemia: a model to investigate the gut‐liver axis RF‐2013‐ 02359864 Development of an integrated risk communication web‐ based model associated with the consumption of food additives RF‐2013‐ 02359865 Project Title: Birth outcomes in women with cancer: a population‐based cohort study RF‐2013‐ 02359869 SAN MATTEO Study of an innovative PET with enlarged field of view (FOV) provided with very high sensitivity and efficiency. Essential for the very early diagnosis of cancer, INFLAMMATORY as well as degenerative diseases and their more conservative treatment. Const AREA P.I. Classificazione 1 Liv. Classificazione 2° liv. Corazza Gino Roberto Biomedica Digestive, Kidney and Urological Systems Gastrointestinal Mucosal Pathobiology ‐ GMPB IZSVE ravarotto licia Biomedica Healthcare Delivery and Methodologies Community‐Level Health Promotion ‐ CLHP ISTITUTO TUMORI MILANO Tagliabue Giovanna Clinico‐ Population Sciences and assistenzial Epidemiology e Epidemiology of Cancer ‐ EPIC CORBELLA FRANCO Biomedica Instrumentation and Systems Development ‐ ISD Sezione Bando: CO= Progetti Cofinanziati con Industria ‐ PE= Progetti Riceractore Italiano all'Estero GR =Giovani Ricercatori ‐ RF= Sezione Ordinaria ‐ NET= Programmi di Rete Bioengineering Sciences and Technologies Pagina 356 di 356