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 SCIENTIFIC PROGRAMME Friday May 23, 2014 16.00 18.00‐18.10 18.10‐18.45 18.50‐19.25 19.30‐20.05 20:15 Chair: Ivan Dikic Arrival and registration Welcome words Ivan Dikic, Goethe University Frankfurt, Germany Keynote lecture: Seven Transmembrane Receptors KL01 Robert Lefkowitz, Duke University, USA Keynote lecture: Cell signalling by receptor tyrosine kinases: from basic KL02 principles to cancer therapy Joseph Schlessinger, Yale University, USA Keynote lecture – in Memory of Tony Pawson Guiding Signals through Anchored Enzyme Complexes KL03 John Scott, University of Washington, USA Welcome dinner Alverde Terrace Saturday May 24, 2014 Session I Oncogenic signalling networks I Chair: John Scott 09.00‐09.35 Keynote lecture: Targeting K‐Ras driven tumors KL04 Mariano Barbacid, Centro Nacional de Investigaciones Oncológicas (CNIO), Spain 09.40‐10.10 Tyrosine kinase signalling networks in human cancer Roger Daly, Monash University, Australia L05 10.15‐10.35 Ubiquitin dependent regulation of MEKK2/3‐MEK5‐ERK5 signalling module by IAPs L06 Krishna Rajalingam, Mainz University, Germany 10.40‐11.10 Tea break Piano Bar Terrace 11.10‐11.40 Novel targets of Raf in tumorigenesis Manuela Baccarini, Max F. Perutz Laboratories (MFPL), Austria L07 11.45‐12.15 BRAF and RAS signalling in melanoma: basic biology and therapeutic options Richard Marais, Cancer Research UK Manchester Institute, UK L08 12.20‐12.30 Increased nanoclustering as a novel mechanism for cancer associated Ras mutations Maja Solman, Turku Centre for Biotechnology, Åbo Akademi, Finland ST01 12.35‐12.45 Akt can promote cancer cell survival independently of kinase activitiy Igor Vivanco, Institute of Cancer Research, Sutton, UK ST02 Development of an IGF2 super‐antagonist by directed evolution of IGF2R Susana Frago, University of Oxford, UK ST03 12.50‐13.00 13.05‐14.30 Lunch break Restaurant Cavtat Chair: Ruth Palmer Session II Genomic integrity in cancer 14.30‐15.05 Keynote lecture: Histidine phosphorylation: the invisible phosphoproteome? Tony Hunter, Salk Institute Cancer Center, USA KL09 15.10‐15.40 Signalling in DNA damage responses Mike Yaffe, MIT, USA L10 15.45‐16.05 Comprehensive genomic analysis of human tumors identifies oncogenic drivers Somasekar Seshagiri, Genentech, USA L11 16.10‐16.40 Tea break Piano Bar Terrace 16.40‐17.10 17.15‐17.45 Control of DNA repair activity at mammalian telomeres Jacqueline J. Jacobs, Netherlands Cancer Institute, The Netherlands Signalling a cell cycle exit after radiation therapy René Medema, Netherlands Cancer Institute, The Netherlands L12 L13
A syndrome with early‐onset hepatocellular carcinoma, instability and progeroid features is caused by mutations in DVC1/SPRTN Janos Terzic, University of Split, Croatia ST04 Balance BRCA1 and 53BP1 at DNA damage sites for DNA repair pathway choice and cancer therapy Junjie Chen, The University of Texas MD Anderson Cancer Center, USA ST05 ST06 17.50‐18.00 18.05‐18.15 18.20‐18.30 Insights into Ribonucleotide Reductase (RNR) regulation during cell cycle progression and DNA damage response Vincenzo D'Angiolella, University of Oxford/Gray Institute, UK 19.00‐23.00 Poster session I/ Fingerfood dinner Bobara Hall/ Quite Salon
Sunday May 25, 2014 Session III Oncogenic signalling networks II Sponsored by the LOEWE project: Ub‐Net Chair: Manolis Pasparakis 09.00‐09.35 Keynote lecture: Survival and Vascular Co‐option of Metastasis Initiating KL14 Joan Massagué, Memorial Sloan Kettering Cancer Center, USA 09.40‐10.10 Evading the anti‐tumor immune response – a novel role for Focal Adhesion Kinase L15 Margaret Frame, Edinburgh University, UK 10.15‐10.35 Targeting Signal Transduction for the Treatment of Acute Myeloid Leukemia L16 Hubert Serve, Goethe University Frankfurt, Germany 10.45‐11.15 Tea Break Piano Bar Terrace 11.15‐11.45 Rap signalling complexes: landmark recognizing modules in cell adhesion and polarity L17 Hans Bos, Utrecht University, The Netherlands 11.50‐12.20 Tumor Suppressor role for the deubiquitinase, BAP1 L18 Vishva Dixit, Genentech, USA ST07 12.25‐12.35 OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3 Lina Herhaus, University of Dundee, UK 12.40‐12.50 OncoMD: A powerful genomic data interpretation tool ST08 to make clinical decisions in cancer Amitabha Chaudhuri, MedGenome Inc., USA 13.00‐15.00 Poster session II & Fingerfood lunch Bobara Hall/ Quite Salon 15.15 Excursion (Dinner not included) Monday May 26, 2014 Session IV Inflammation and cancer Chair: René Medema 09.00‐09.35 Keynote lecture: Regnase‐1‐mediated regulation of the immune response KL19 Shizuo Akira, Osaka University, Japan 09.40‐10.10 IKK/NF‐kB signalling in inflammation and cancer L20
Manolis Pasparakis, University of Cologne, Germany ST09 10.15‐10.25 Loss of NF‐kB1 causes gastric cancer via cytokine mediated chronic inflammation Lorraine O’Reilly, The Walter and Eliza Hall of Medical Research, Melbourne, Australia 10.30 ‐10.40 Targeting lysosomal adaptor complexes during cancer progression ST10 David McEwan, Goethe University Frankfurt, Germany 10.50‐11.20 Tea break Piano Bar Terrace 11.20‐11.50 The EGFR ‐ exploring the unexpected L21 Maria Sibilia, Medical University of Vienna, Austria 11.55‐12.25 A Numb/p53 circuitry couples control of replicative self‐renewal L22 and tumour suppression in normal and cancer mammary epithelial cells Pier Paolo Di Fiore, Istituto FIRC di oncologia molecolare (IFOM), Italy 12.30‐12.50 Molecular basis for engineering myeloid suppressors L23 Peter Murray, St. Jude Children's Research Hospital, USA 13.00‐14.30 Lunch Restaurant Cavtat Session V 14.30‐15.05 15.10‐15.40 15.45‐16.15 16.15‐16.45 16.50‐17.20 17.25‐17.45 Oncology pathways in cancer metabolism and development Chair: Margaret Frame Keynote lecture: Signalling in wound‐induced skin cancer KL24 Fiona Watt, University of Cambridge, UK Anaplastic Lymphoma Kinase signalling in Drosophila and mouse models L25 Ruth Palmer, Umeå University, Sweden Tea break Piano Bar Terrace Structural regulation of ubiquitin pathways L26 Brenda Schulman, St. Jude Children's Research Hospital, USA Mitotic Wnt signalling regulates cell growth and proliferation L27 Christof Niehrs, Institute for Molecular Biology (IMB), Germany L28 The function of p63 and p73 in genetic quality control and cancer developmen Volker Dötsch, Goethe University Frankfurt, Germany Poster session III Bobara Hall 18.00‐20.00 20.30‐23:30 Farewell dinner and dancing After midnight Spinaker Restaurant Night Club Poseidon will be opened Tuesday May 27, 2014 Session VI Cell death and autophagy pathways Chair: Maria Sibilia 09.00‐09.35 Keynote Lecture: Life and Death Decisions: Annexin AI expressed KL29 on apoptotic cells downregulates the immune response Peter Krammer, German Cancer Research Center (DKFZ), Germany 09.40‐10.10 Caspase‐2 as a tumour suppressor L30 Sharad Kumar, Centre for Cancer Biology (CCB), Australia 10:15‐10:25 Pushing Myc inhibition towards the clinic using a directly‐ ST11 deliverable cell‐penetrating peptide Marie‐Eve Beaulieu, Vall d'Hebron Institute of Oncology, Spain 10.30‐11.00 Tea break Piano Bar Terrace 11.00‐11.35 Keynote lecture: Autophagy in cancer KL31 Yoshinori Ohsumi, Tokyo Institute of Technology, Japan 11.40‐12.10 Autophagy in haematological tumors L32 Katharina Simon, University of Oxford, UK 12.15‐12.45 Autophagy: Friend or foe in the treatment of fusion L33 protein‐associated leukemias? Anne Simonsen, University of Oslo, Norway 12.50‐13.00 Salmonella drives cellular transformation and cancer ST12 Tiziana Scanu, The Netherlands Cancer Institute, The Netherlands 13.05‐13.15 Poster award ceremony and closing remarks 13.15‐14.30 Lunch Restaurant Cavtat Departure