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E.C.CO. Protocol title Study Type Primary Objective Secondary Objective Inclusion criteria Exclusion criteria Treatment Duration of study Endometrial Cancer – COnservative treatment A multicentre registry study Observational, prospective (patient registry) [The study runs within the framework of Gynecologic Cancer InterGroup (GCIG), thus, participating centres must belong to one of the qualified national groups] - Proportion of complete regression - Duration of response - Frequency and pattern of relapse - Frequency of metachronous ovarian cancer - Tumor-related deaths - Treatment related morbidity - Frequency of spontaneous pregnancies - Frequency of pregnancies after ART - Pattern of residual disease on definitive surgical specimens - Age up to 40 years - Histologically proven EC - Strong desire to preserve fertility and complete the follow-up program - Oncology and fertility counseling and informed consent - History of previous/concomitant cancer (except for adequately treated skin basal cell or in situ cervical cancer) - Patient belonging to a family with hereditary non-polyposis colorectal cancer (Lynch II syndrome) - Synchronous ovarian cancer at magnetic resonance imaging (MRI) or laparoscopy - Contraindications for progestin treatment or levonorgestrel-releasing intrauterine system (LNG-IUS) insertion - Since this is a registry study, there is not one defined protocol, but treatment, however, is to be administered according to a IRB-approved protocol (except for the countries where conservative treatment can be given outside a IRB-approved study because considered as a standard procedure). Already active protocols in GCIG member institutions are incorporated in the study package and recommended - Pretreatment fertility counseling and patient informed consent are considered mandatory - Pathological criteria are defined for differential diagnosis of endometrial hyperplasia and low grade adenocarcinoma - Definitive surgery should be planned, and pathological data available A first phase of three years is planned, eventually followed by further three years. For information, please contact: Stefano Greggi – Istituto Nazionale Tumori di Napoli [email protected]