Download CureVac Collaborates with the Cancer Research Institute and

CureVac Collaborates with the Cancer Research Institute and
Ludwig Cancer Research to Enable Clinical Testing of Novel
Immunotherapy Treatment Options for Cancer
TÜBINGEN, Germany, and NEW YORK, Nov. 4, 2013 – The non-profit Cancer Research
Institute (CRI) and Ludwig Cancer Research (Ludwig), and CureVac, a clinical stage
biopharmaceutical company that has pioneered the development of a new class of therapies
and vaccines based on messenger RNA (mRNA), today announced that they will collaborate
to enable clinical testing of novel cancer immunotherapy treatment options.
Amplifying the immune system’s ability to recognize, attack, and destroy cancer, is a
therapeutic strategy that recent studies have demonstrated to be a potent and effective
approach to treatment of some cancers. Product approvals and promising clinical data for
various checkpoint inhibitors, which block proteins responsible for immune system inhibition,
support the potential of combining CureVac's RNActive® vaccines with this new class of
treatment to significantly improve cancer patient survival.
“The collaboration with CureVac is the fourth in a series of partnerships CRI and Ludwig
have struck with biotech and pharmaceutical companies in order to bring next-generation
combination immunotherapies into clinical studies sooner than would otherwise happen,”
said Adam Kolom, managing director of CRI’s non-profit venture fund, which makes
investments to support the costs of innovative immunotherapy clinical trials. “Each of our
partnerships increases investigator access to one or more high-promise immune reagents,
and brings new and potentially more effective combination treatments to patients.”
Ludwig and CRI will conduct up to five clinical studies of cancer immunotherapy
combinations through their jointly coordinated CVC Trials Network using CureVac’s
investigational clinical stage drug, CV9202, combined with other priority agents available to
CRI and Ludwig from their internal portfolios or accessed through additional industry
partnerships. CV9202 contains NSCLC-associated antigens and is the optimized successor
of CV9201, which has successfully completed a phase I/IIa clinical trial demonstrating its
safety and immunogenicity. Additional investigational clinical stage drugs from CureVac’s
product pipeline can be added.
“Combining immunotherapy approaches holds great potential for the treatment of cancer,“
said Jonathan Skipper PhD, executive director of technology development at the Ludwig
Institute for Cancer Research. “CureVac’s immunotherapy platform, which contains several
Ludwig antigens, has shown promising results in early stage clinical trials. Our collaboration
will enable us to combine this novel technology with different immunotherapeutic approaches
to attack a patient’s cancer on multiple fronts and therefore decrease the chances of immune
escape,“ added Skipper.
“There has been a great amount of progress made in the cancer immunotherapy field
recently, and we believe that checkpoint inhibitors could work even more efficiently with
fewer side effects when combined with targeted anti-tumor guidance through an efficient
vaccination approach such as RNActive®,” said Ingmar Hoerr, Ph.D., chief executive officer
at CureVac. “The collaboration with the Cancer Research Institute and Ludwig Cancer
Research will provide us with important insights about combination immunotherapies such as
combinations with checkpoint inhibitors. RNActive® vaccines have been shown to elicit a
safe, effective and robust immune response against encoded cancer antigens in cancer
patients, and we continue to work with partners worldwide to develop immune-based
therapies to combat debilitating diseases such as cancer.”
Financial terms were not disclosed.
About RNActive®
CureVac is combining both the antigenic and adjuvant properties of mRNAs to develop novel
and effective mRNA vaccines. RNActive® vaccines are comprised of modified and formulated
mRNA with three distinct features: The mRNA vaccines are translated into the target
antigens, and the formulation and modifications lead to translatability ensuring (1) strong
antigen expression, (2) increased stability and (3) enhanced immune-stimulatory activity.
About CV9202
CureVac’s CV9202 RNActive® vaccine is being developed for the treatment of patients with
non-small cell lung cancer (NSCLC). CV9202 consists of six RNActive®-derived molecules
coding for six different NSCLC-associated antigens.
About Ludwig Cancer Research
Ludwig Cancer Research is an international collaborative network of acclaimed scientists
with a 40-year legacy of pioneering cancer discoveries. Ludwig combines basic research with
the ability to translate its discoveries and conduct clinical trials to accelerate the development
of new cancer diagnostics and therapies. Since 1971, Ludwig has invested more than $1.6
billion in life-changing cancer research through the not-for-profit Ludwig Institute for Cancer
Research and the six U.S.-based Ludwig Centers.
www.ludwigcancerresearch.org
About the Cancer Research Institute
The Cancer Research Institute (CRI), established in 1953, is the world’s only non-profit
organization dedicated exclusively to transforming cancer patient care by advancing scientific
efforts to develop new and effective immune system-based strategies to prevent, diagnose,
treat, and cure cancer. Guided by a world-renowned Scientific Advisory Council that includes
three Nobel laureates and 25 members of the National Academy of Sciences, CRI has
invested $263 million in support of research conducted by immunologists and tumor
immunologists at the world’s leading medical centers and universities, and has contributed to
many of the key scientific advances that demonstrate the potential for immunotherapy to
change the face of cancer treatment.
www.cancerresearch.org
About CureVac
CureVac, a clinical stage biopharmaceutical company from Tübingen, Germany, is
advancing the field of mRNA-based vaccination. The company uses its technology platforms
for the development of novel therapeutic mRNA vaccines (RNActive®) for cancer and
prophylactic vaccines for infectious diseases. Furthermore CureVac develops adjuvants
based on non-coding RNAs (RNAdjuvant®) for enhancing the immune response of other
vaccines. The company has successfully completed Phase I/IIa studies with its RNActive®
cancer vaccines in prostate cancer and non-small cell lung cancer (NSCLC). Results so far
have shown that mRNA-based products are safe and capable of inducing balanced immune
responses including humoral and cellular, Th1 and Th2 and effector and memory responses.
CureVac is currently running a number of clinical trials with its RNActive® vaccines, including
a large randomized Phase IIb clinical trial in prostate cancer. In addition to developing its
own pipeline, CureVac is collaborating with Sanofi Pasteur,In-Cell-Art and Janssen
Pharmaceuticals for the development of prophylactic vaccines in infectious diseases utilizing
its RNActive® technology platform.
www.curevac.com
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Media Contacts
Dr. Martina Schwarzkopf
Russo Partners, New York
T: + 1 (212) 845 4292
M: + 1 (347) 591 8785
T: + 1 (212) 845 4251
[email protected]
Verena Lauterbach, Manager Communications
CureVac GmbH, Tübingen, Germany
T: +49 (0) 7071 920 53 756
[email protected]
Brian M. Brewer
Cancer Research Institute, New York, NY USA
T: + 1 (212) 688-7515 x242
[email protected]
Rachel Steinhardt
Ludwig Institute for Cancer Research, New York, NY USA
T: + 1 (212) 450-1582
[email protected]