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Mitotic Division in Cancer Cells Grading Rubric Name:_________________________________ Period:______ Date:______________________ 1. Prepare a bar graph that compares the length of time spent in each phase of the cell cycle for healthy and cancerous cells. (1 point per bullet; 4 points max) X/Y axes are correctly labeled and include units when appropriate Graph appropriately scaled and data correctly represented Descriptive and appropriate title Data correctly identified with a key 2. Run a chi-square analysis on the data from Table 1 to determine whether there is a significant difference in the number of cells found in each phase for cancerous stomach cells. Correct setup and use of the X2 formula (1 point) 3. Analysis of Data a. General trend in data summarized (1 point) Both cancerous and healthy cells spend more time in interphase than M phase b. Comparison of data (1 point) Cancerous cells spend more time in M phase and less time in interphase than do healthy cells. OR Healthy cells spend less time in M phase and more time in interphase than do cancerous cells c. Chi Square analysis (1 point per bullet, 5 points max) Null hypothesis is correctly stated Comparison of X2 value to critical value P-value and degrees of freedom are identified Reject/fail to reject null hypothesis What it means to reject/fail to reject null hypothesis d. Elaboration of analysis Cancerous cells have lost the function of 2 or more genes that are involved in cell cycle control. (1 point) Example of gene and description of loss of function (1 point per column; 2 points max) Gene (1 point max) Loss of Function (1 point max) p53 tumor suppressor; checkpoints ignored; increased speed of cell apoptosis signal; cycle/division stalls cell cycle RAS proto-oncogene; Cell cycle overstimulated; increased speed of cell stimulates cell cycle/cell division cycle Cyclins proto-oncogene; Cell cycle overstimulated; increased speed of cell stimulates cell cycle/cell division cycle