Download THE WAR ON PANCREATIC CANCER

Training to Improve Survival
Initiative
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“THE WAR ON PANCREATIC CANCER
REQUIRES DEDICATION”
SINJAN BOSE
APRIL 23, 2012
Facts about Pancreatic Cancer
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 4th leading cause of death
 Only one with a 5 year survival rate of 6%
 Survival rate has not improved since passage of
National Cancer Act of 1971
 In 2012, 43,920 Americans will be diagnosed and
37,390 will die
 75% of patients die within the first 12 months of
diagnosis
 Only 2% of NCI’s annual budget allocated
2012 Relative Five Year Survival Rates
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NCI Annual Funding 2001-2010
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Issues
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 Lack of funding towards research
 Physician and public awareness of the disease
 Future supply of scientists in serious jeopardy
Pancreatic Research and Education Act
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 Develop a Strategic Plan for Research
 Cancer Research Incubator Pilot for the Deadly
Cancers
 Strengthening and Expanding SPORE for Pancreatic
Center
 Promoting Physician and Public Awareness
Strategic Plan for Research
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 Amend Part B of title III of Public Health Service Act
(42 U.S.C. 243 et. seq.)

§ 320B(a). Pancreatic Cancer Initiative. “The Secretary shall
establish and implement a Pancreatic Cancer Initiative to
assist in coordinating activities to address the high mortality
rate associated with pancreatic cancer. Such initiative shall
focus on:

(A) advancing research on the causes, diagnosis, and treatment of
pancreatic cancer with the goal of increasing 5-year survival”
Strategic Plan for Research
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 Amend Part B of title III of Public Health Service Act
(42 U.S.C. 243 et. seq.)

§ 320B(b). Interdisciplinary Pancreatic Cancer Coordinating
Committee.
(1) Establishment
 (2) Membership
 (3) Responsibilities
 (4) Strategic Plan
 “(A) Development – The Committee shall develop not later than
6 months of the Committee’s establishment and update not less
than every 5 years thereafter a strategic plan for the conduct and
support of pancreatic cancer research and awareness for the
upcoming fiscal 5-year period”

Strategic Plan for Research
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 Amend Part B of title III of Public Health Service Act (42
U.S.C. 243 et. seq.)

§ 320B(b). Interdisciplinary Pancreatic Cancer Coordinating
Committee.
(1) Establishment
 (2) Membership
 (3) Responsibilities
 (4) Strategic Plan
 (5) Prioritization and Award of NIH Research Grants
 In General. – The Committee shall conduct evaluations and make
recommendations as needed to the Secretary, the Director of
National Institutes of Health, and the Director of the National
Cancer Institute regarding prioritization and award of NIH
research grants relating to pancreatic cancer

Cancer Research Incubator Pilot for the Deadly
Cancers
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 Amend Part B of title IV of Public Health Service Act
(42 U.S.C. 284 et. seq.)

§ 409K. Cancer Research

(a) Cancer Research Incubator Pilot Project –
 (1) Grants –
• (A) In General – The Secretary may award grants to research
institutions for use in developing innovative compounds or
technologies for the prevention, early detection, or treatment of
those cancers with 5-year survival rates of less than 50%
Strengthening and Expanding of Excellence for
Pancreatic Center
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 Amend Part B of title IV of Public Health Service Act
(42 U.S.C. 284 et. seq.)

§ 409K. Cancer Research

(b) Centers of Excellence –
 (1) Designation – The Secretary may designate two additional
Specialized Programs of Research Excellence (SPOREs)
focusing solely on pancreatic cancer research. In carrying out
this paragraph, the Secretary may choose to designate 1 or more
satellite centers that augment the work of a previously
designated Specialized Program of Research Excellence
Promoting Physician and Public Awareness
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 Amend Part B of title III of Public Health Service Act
(42 U.S.C. 243 et. seq.)

§ 320B(c). Physician Awareness

(1) Program. – The Secretary, in consultation with the Director of
the National Institutes of Health, the Director of the Centers for
Disease Control and Prevention, and relevant patient advocate and
physician organizations, shall develop a primary care provider
education program on pancreatic cancer. The Secretary may
include in such program accredited continuing medical education
and such other activities as the Secretary determines appropriate
The NCI and Pancreatic Cancer
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 Allocates budget through grant mechanisms – R
grants
 From 2008 to 2009 number of R grants increased
from 216 to 231 but amount of grants decreased from
$49.1 million to $48 million
 Fellowship, Career, and Training Awards (FKT)
decreased by 15% from 2008 to 2009
The NCI and Pancreatic Cancer
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Training to Improve Survival Initiative
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 Amend § 320B. Pancreatic Cancer Initiative
 Add (a)(4)(C)(iv).

“The grant will develop education and training resources
for investigators and health care providers about
pancreatic cancer risk assessment, evaluation protocols,
and sample collection.”
Policy Paramours
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 U.S. Senate
 Sheldon Whitehouse (D-RI)
 Tom Harkin (D-IA)
 U.S. House of Representatives
 Anna Eshoo (D-CA)
 Leonard Lance (R-NJ)
 Dave Reichert (R-WA)
 Tim Murphy (R-PA)

Republican Physician’s Caucus Co
Opposition
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 U.S. House of Representatives
 Fred Upton (R-MI)
 Ed Whitefield (R-KY)
 Steve Scalise (R-LA)
Stakeholders
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 Governmental
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Center for Medicare and Medicaid Services
Center for Disease Control and Prevention
Department of Health and Human Services
National Institutes for Health
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National Cancer Institute
Food and Drug Administration
 Non-governmental
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Pancreatic Cancer Action Network (PANCAN)
Cancer Leadership Council
American Association of Cancer Research (AACR)
American Pancreatic Association
Doctors, Caregivers, Scientists
Major Hospitals
References
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 American Cancer Society. Cancer Facts & Figures 2012. Atlanta:
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American Cancer Society; 2012
Surveillance, Epidemiology, and End Results (SEER) Program,
National Cancer Institute. “Age-Adjusted U.S. Death Rates and
Trends for the Top 15 Cancer Sitesa by Race/Ethnicity, Both Sexes”
Smith BD, Smith GL, Hurria A, Hortobagyi GN, Buchholz TA.
Future of Cancer Incidence in the United States: Burdens Upon an
Aging, Changing Nation. J Clin Oncol. 2009
Li D, Xie K, Wolff R, Abbruzzese JL. Pancreatic Cancer.
Lancet.2004; 363:1049 – 1057
Oettle H, Post S, Neuhaus P, et al. Adjuvant Chemotherapy With
Gemcitabine vs Observation in Patients Undergoing Curative-Intent
Resection of Pancreatic Cancer: A Randomized Controlled Trial.
JAMA. 2007;297:267-277.
American Cancer Society.
www.pancan.org