Download Is use of statin associated with better histopathologic parameters in

Is Use of Statin Associated with Better Histopathologic Parameters in Men with Biopsy Proven
Cancer? A Retrospective Matched Controlled Anaylsis
Introduction and Objectives: The objective of this study is to determine whether a preoperative use
of HMG-CoA inhibitors (statin) has an influence on tumor aggressiveness in men with diagnosed
prostate cancer. We examine, in our patient population, the relationship between a preoperative
administration of HMG-CoA inhibitors (statin) and the final histology after a radical prostatectomy
regarding tumor size and Gleason grading.
Materials and Methods: In a retrospective review, we identified all patients who presented with a
prostate cancer at our institution to a radical prostatectomy and who had taken statin preoperatively.
We evaluated a subgroup of 252 patients with prostate cancer. Forty of these 252 patients took statin
preoperatively. As part of our study we compared these 40 patients who took preoperatively statin
with the rest of the 212 who did not, in terms of age, BMI, PSA, C-reactive protein, intraoperative
blood loss, Gleason-score and upgrading/downgrading on the final pathology.
Results: Overall, median serum prostate specific antigen was slightly higher in patients on
preoperative statin medications 6, 52 ng/ml, compared to the PSA value in the control group 6,
11ng/ml. The median intraoperative blood loss was 300 ml in both groups also in the serum levels of
C-reactive protein was 1.5 mg / L in both groups equal. Comparing the preoperative Gleason-score,
the biopsy and the Gleason-score on the final pathology we observe a downgrading in 6/40 (15%)
patients and a upgrading on 13/40 (32.5%) patients on the statin group. The control group showed a
downgrading only in 12, 7% patients and a upgrading in 83/212 (39.1%) patients.
Conclusion: The present study suggests that those patients with prostate cancer who took statin
before the surgery have a better Gleason-Score and thus that this medication may have an influence
on the biological aggressiveness of the prostate cancer.