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Meth: Meth consists of constituent molecules that are, in nature, toxic, corrosive, and highly flammable. Although the constituent molecules differ from recipe to recipe, meth commonly consists of acetone, lithium, hydrochloric acid, toluene, pseuedoephedrine, sodium hydroxide, sulfuric acid, and anhydrous ammonia. It is important to note that each of these molecules individually are detrimental to the homeostatic mechanisms—the biological functionings—of the respiratory, nervous, and cardiovascular systems. However, when combined together, the affects of these molecules multiply. Stimulating the secretion of chemicals upon consumption, meth is responsible for the subsequent results that occur as a result of increased molecule secretion. Beginning with its entrance into the body via snorting, smoking, ingesting or injecting, meth immediately enters the blood stream, disrupting the usual function of the cardiovascular system. Biologically, blood vessels—arteries, veins, and capillaries—are pivotal to blood transport throughout the body (veins and arteries) and gas exchange (capillaries). When meth enters the blood stream, arteries immediately conduct the stimulant to organs and tissues in the body. Neurogenically, meth increases the heart rate by affecting the pons and medulla oblongata in the central nervous system (see Gavy). As a result, a greater volume of blood is pumped into the arteries, increasing the pressure within the arteries, resulting in vasoconstriction—narrowing of blood vessel radius. This, then, reduces blood flow, increases blood pressure, and increases blood clotting. Consequently, heart inflammation, seizures, abnormally long, painful headaches, irregular heartbeats, and brain bleeding occur. Taken further, vasoconstriction reduces the amount of oxygen supplied to the heart. The poor supply of oxygen to the heart, medically coined myocardial ischaemia, results in death of the heart muscle and/or an increase in size of the heart muscle, coined cardiomyopathy. Additionally, the constriction of blood vessels can lead to pulmonary edema— excessive fluid in the lungs—leading to chronic lung disease. According to the American College of Physicians, patients with pulmonary edema and idiopathic pulmonary arterial hypertension (PAH) significantly more likely to have used stimulants, such as meth, than patients with other forms of pulmonary hyperextension. Make no mistake, meth is not confined within the cardiovascular, pulmonary, and nervous systems; it directly affects every system in the body. Because the blood vessels provide blood to tissues and organs in the body, meth has a direct affect on every system. Biologically, in the excretory system, blood flows through the kidneys from the renal arteries, and is filtered to extract waste material. When the blood transport system decreases in efficiency due to vasoconstriction, the filtering process of the kidneys decrease, ceasing the natural filtering process and ultimately leading to kidney failure, inflammation, and/or viral infection. More importantly, however, the kidneys produce less urine with less blood flow, recycling toxic waste back into the bloodstream. This, then, deposits unsecreted waste in the bladder, ultimately resulting in bladder infections. According to the Drug Rehab Center Network, “a high percentage of people that die from methamphetamine overdoses have symptoms of shock, coma, inability to pass urine, and muscle twitching.” Sources: http://www.livestrong.com/article/86587-effects-methamphetamine-arteriesblood/ http://www.whitehouse.gov/ondcp/anti-drug-media-campaign http://www.sciencedaily.com/releases/2007/06/070625193422.htm http://www.ndlerf.gov.au/pub/Cardiac%20probs%20and%20amphet.pdf http://www.westword.com/2003-09-04/news/72-hour-party-people/full https://www.ncjrs.gov/pdffiles1/nij/grants/209730.pdf http://chestjournal.chestpubs.org/content/130/6/1657.full.pdf http://www.jimmunol.org/content/185/5/2867.full http://www.medicalnewstoday.com/releases/101323.php http://www.smokemeth.com/images/dangers-of-meth-large.gif