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Curriculum Vitae PERSONAL Name: Born: Marital status: Marcel Paul Copper. March 7, 1963 in The Hague, the Netherlands. Married, 4 children. EDUCATION/EMPLOYMENT 1975-1981 VWO: Caland Lyceum, Rotterdam, the Netherlands. 1981-1988 Medicine, University of Leiden, the Netherlands. 1984: Research cardiology, Edinburgh, Scotland. Student-assistant positions: Anatomy, neuroanatomy, social health and medical informatics. 1988-1990 First Lieutenant doctor: Military Hospital Dr. A. Mathijsen, Department of Otolaryngology, Utrecht, the Netherlands. 1990 (March-Sept) Resident in general surgery, Diaconessenhuis, Leiden, the Netherlands. 1990-1992 Researcher: Tumour Biological Laboratory of the Department of Otolaryngology, head and neck surgery, Free University Hospital, Amsterdam, the Netherlands. 1992-1997 Training for Otolaryngologist: Free University Hospital, Amsterdam, the Netherlands. Trainers: Prof. Dr. G.B. Snow, Prof. Dr. I.B. Tan. Registration as an Otolaryngologist: April 1, 1997. 1997-1999 Academic specialist, Academic Medical Centre, Amsterdam, the Netherlands. Focus areas: Head and neck surgery, Otology and Paediatric Otolaryngology. March 1998 PhD in Medicine, Free University, Amsterdam, the Netherlands. Thesis: Biomarkers in chemoprevention of second primary tumours in head and neck cancer patients. Promotor: Prof. Dr. G.B. Snow. 1999-2000 Fellowship in Head and neck surgery, Netherland Cancer Institute, Amsterdam, the Netherlands. 2000-March 2002 Head and neck surgeon, Free University Hospital, Amsterdam, the Netherlands. Focus areas: Oncology, reconstructive surgery. 2001-2008 Consultant Head and neck surgeon, Emma Children’s Hospital and Academic Medical Centre, Amsterdam, the Netherlands. - Dr. M.P. Copper, -1 - 2002-2008 Head and neck surgeon, Netherland Cancer Institute, Amsterdam, the Netherlands. 2002-present Otolaryngologist/Head and neck surgeon, Sint Antonius Hospital, Nieuwegein, the Netherlands. Focus areas: Head and neck surgery and surgery for obstructive sleep apnea syndrome. 2008-present Trainer in Otolaryngology, Sint Antonius Hospital, Nieuwegein/Utrecht, the Netherlands. 2016-present ENT-surgeon at the Ruysdael Voice Clinic, Amsterdam, the Netherlands. OTHER POSITIONS AND MEMBERSHIPS Member of the Dutch Society for Otolaryngology/Head and neck surgery. Member Dutch Committee for Eye and Orbital Tumours. Member of the Dutch Guideline Committee for Oesophageal Cancer. Board member (Secretary) of the ENT association of the Central Netherlands. Board member (Finance) of the medical staff, Sint Antonius Hospital, Nieuwegein. Member of the Dutch Consilium of Otolaryngology. Member of the Dutch Visitation Committee for Teaching Hospitals in Otolaryngology. Member of the European Laryngological Society. International member American Academy of Otolaryngology - Head & Neck Surgery. Corresponding member American Head and Neck Society. Member of the Dutch Working group on OSAS. Member of the International Sleep Surgical Sleep Society. Representative of Dutch Society for Otolaryngology/ Head and neck surgery at the RGS (Registration committee of Medical Specialists). PRICES 1994: Annual Award of the Dutch Association of Oral Surgery and Oral Surgery for research on genetic factors in head and neck cancer. 1999: Annual Award (2nd) of the Dutch Society of Otolaryngology/Head and neck surgery for the thesis “Biomarkers in chemoprevention of second primary tumours in head and neck cancer patients”. - Dr. M.P. Copper, -2 - PUBLICATIONS Thesis Biomarkers in chemoprevention of second primary tumours in head and neck cancer patients. ISBN 90-9011394-0, march 1998. Scientific publications 1 C.F. Smit, M.P. Copper, J.M.G. Urlings. Two HIV-seropositive militaries having ENTcomplaints. Dutch Military Journal of Medicine, 5:163-165 (1990). 2 M.P. Copper, B.J.M. Braakhuis, N. de Vries, G.A.M.S. van Dongen, J.J.P. Nauta, G.B. Snow. A panel of biomarkers of carcinogenesis of the upper aerodigestive tract as potential intermediate end points in chemoprevention trials. Cancer, 71:825-830 (1993). 3 J. Cloos, I. Steen, B.J.M. Braakhuis, M.P. Copper, N. de Vries, J.J.P. Nauta, G.B. Snow. Increased mutagen sensitivity in head-and-neck squamous-cell carcinoma patients, particularly those with multiple primary tumors. International Journal of Cancer, 56:816-819 (1994). 4 M.P. Copper, A. Jovanovic, J.J.P. Nauta, B.J.M. Braakhuis, N. de Vries, I. van der Waal, G.B. Snow. Role of genetic factors in the etiology of squamous cell carcinoma of the head and neck. Archives of Otolaryngology Head and Neck Surgery, 121:157-60 (1995). 5 L.J.J.M. Bauwens, M.P. Copper, J.T. Schmidt. Life-threatening angioedema as a side effect of angiotensin-converting-enzyme (ACE) inhibitors. NTVG, 139:674- 677 (1995). 6 J.A.M. Beliën, M.P. Copper, B.J.M. Braakhuis, G.B. Snow, J.P.A. Baak. Standardization of counting micronuclei: definition of a protocol to measure genotoxic damage in human exfoliated cells. Carcinogenesis, 16:2395-2400 (1995). 7 M.P. Copper, F.B.J.M. Thunnissen, N. de Vries, G.B. Snow, B.J.M. Braakhuis. Cytomorphometric parameters in exfoliated cells as biomarkers in head and neck cancer chemoprevention. International Journal of Oncology, 9:1071-1075 (1996). 8 T. Teerlink, M.P. Copper, I. Klaassen, B.J.M. Braakhuis. Simultaneous analysis of retinol, all-trans- and 13-cis-retinoic acid and 13-cis-4-oxoretinoic acid in plasma by liquid chromatography using on-column concentration after single-phase fluid extraction. Journal of Chromatography B, 694:83-92 (1997). 9 J.W. Wirds, E.S. Boon, G.J. Scheffer, M.P. Copper, H.F. Mahieu. Percutaneous tracheotomy using a dilating forceps: a rapid and safe technique. Intensive Care Reviews, 12:9-14 (1997). 10 B.J.M. Braakhuis, I. Klaassen, B.M. van der Leede, J. Cloos, R.H. Brakenhoff, M.P. Copper, T. Teerlink, H.F.J. Hendriks, P.T. van der Saag, G.B. Snow. Retinoid metabolism and all-trans retinoic acid induced growth inhibition in head and neck squamous cell carcinoma cell lines. British Journal of Cancer, 76:189-197 (1997). - Dr. M.P. Copper, -3 - 11 M.P. Copper, R.H. Brakenhoff, J. Cloos, G.B. Snow, B.J.M. Braakhuis. All-trans retinoid acid induced gene expression and growth inhibition in head and neck cancer cell lines. European Journal of Cancer Part B: Oral Oncology, 33:270-274 (1997). 12 I. Klaassen, M.P. Copper, R.H. Brakenhoff, S.J. Smeets, G.B. Snow, B.J.M. Braakhuis. Exfoliated oral cell messenger RNA - suitability for biomarker studies. Cancer Epidemiology, Biomarkers & Prevention, 7:469-472 (1998). 13 H.A.J. Brok, R.J. Stroeve, M.P. Copper, P.F. Schouwenburg. The treatment of hypertonicity of the pharyngo-oesophageal segment after laryngectomy: a review. Clinical Otolaryngology, 23:302-307 (1998). 14 M.P. Copper, I. Klaassen, T. Teerlink, G.B. Snow, B.J.M. Braakhuis. Plasma retinoid levels in head and neck cancer patients: a comparison with healthy controls and the effect of retinyl palmitate treatment. European Journal of Cancer Part B: Oral Oncology, 35:40-44 (1999). 15 H.A.J. Brok, M.P. Copper, R.J. Stroeve, B.W. Ongerboer de Visser, A.J. Venkervan Haagen, P.F. Schouwenburg. Evidence for recurrent laryngeal nerve contribution in motor innervation of the human cricopharyngeal muscle. Laryngoscope, 109:705-708 (1999). 16 M.P. Copper. Biomarkers for chemoprevention of second primary tumors in the head and neck. Kanker, 23(2):30-31 (1999). 17 D.J. Menger, M.P. Copper, R.A. Tange, P.F. Schouwenburg. An extraordinary cause of nasal obstruction: A leiomyosarcoma. NTvKNO, 2:62-65 (1999). 18 M.P. Copper, C.F. Smit, L.D. Stanojcic, P.P. Devriese, P.F. Schouwenburg, E.M.H. Mathus-Vliegen. The role of laryngo-pharyngeal reflux in head and neck cancer patients. Laryngoscope, 110:1007-1011 (2000). 19 P. Merkus, M.P. Copper, M.H.J. van Oers, P.F. Schouwenburg. Lymphoma in the ear. ORL J Otorhinolaryngol Relat Spec, 62:274-277 (2000). 20 C.F. Smit, M.P. Copper, J.A.M.J. van Leeuwen, I.G. Schoots, L.D. Stanojcic. Effect of cigarette smoking on laryngopharyngeal and gastro-oesophageal reflux. Annals of Otology, Rhinology and Laryngology, 110:190-193 (2001). 21 I.B. Tan, J.L.N. Roodenburg, M.P. Copper, J.W.W. Coebergh, I. van der Waal. Early diagnosis and prevention of malignant tumors in the head and neck region. NTVG, 145:567-572 (2001). 22 Buwalda J, Schouwenburg PF, Blank LE, Merks JH, Copper MP, Strackee SD, Voute PA, Caron HN. A novel local treatment strategy for advanced stage head and neck rhabdomyosarcomas in children. Results of the AMORE protocol. Eur J Cancer, 39:1594-602 (2003). 23 M.P. Copper, I.B.Tan, H. Oppelaar, M.C. Ruevekamp, F.A. Stewart. Foscan mediated photodynamic therapy in early stage squamous cell carcinoma of the head and neck. Archives of Otolaryngology Head and Neck Surgery, 129:709-711 (2003). 24 J. Buwalda , L.E. Blank, P.F. Schouwenburg, M.P. Copper, S.D. Strackee, P.A. Voute, J.H. Merks, H.N. Caron. The AMORE protocol as salvage treatment for nonorbital head and neck rhabdomyosarcoma in children. Eur J Surg Oncol, 30:884892 (2004). - Dr. M.P. Copper, -4 - 25 C.E. Lopuhaä, M.P. Copper, A.J.M. Balm. Obstructive sleep apnea syndrome in a child. NTvKNO, 11:143-145 (2005). 26 A.J.M. Balm, P.F.J.M. Lohuis, M.P. Copper. Educational session: How I do it Unwrapping the neck node levels around a sternocleidomastoid muscle bar: a systematic way of performing (modified) radical neck dissection. Eur J Surg Oncol. 31:1216-1221 (2005). 27 L. Smeele, I.B. Tan, M.P. Copper. Foscan-mediated photodynamic therapy (PDT) in the treatment of primary squamous cell carcinoma of the head and neck. Int J Oral Maxillofac Surg. 34:38-38 (2005). 28 M.P. Copper, M. Triesscheijn, I.B. Tan, M.C. Ruevekamp, F.A. Stewart. Photodynamic therapy in the treatment of multiple primary tumors in the head and neck. Clin Otolaryngol, 32:185-9 (2007). 29 B. Karakullukcu, K. van Oudenaarde, M. Copper, M. Klop, R. van Veen, B. Tan. Photodynamic therapy of early stage oral cavity and oropharynx neoplasms: an outcome analysis 170 patients. Eur Arch Otorhinolaryngol. 268:2810288 (2011). 30 D.M.J. Milstein, A.M. van Kuijen, M.P. Copper, W.F. Fokkens, I.B. Tan, C. Ince. Monitoring microcirculatory alterations in oral squamous cell carcinoma following photodynamic therapy. Photodiagnosis Photodyn Ther, 9:69-75 (2012). 31 B. Karakullukcu S.D. Stoker, A.P. Wildeman, M.P. Copper, M.A. Wildeman I.B. Tan. A matched cohort comparison of mTHPC-mediated photodynamic therapy and trans-oral surgery of early stage oral cavity squamous cell cancer. Eur Arch Otorhinolaryngol, 270:1093-7 (2013). 32 S. van Egmond, A. Aarts, M.P. Copper. Effect of multilevel surgery in patients with obstructive sleep apnea syndrome. NTvKNO, 20:45-9 (2014). PRESENTATIONS November 1990, Amsterdam. First Euroscan-meeting: "Current status of the Euroscan trial". June 1991, Amsterdam. EORTC head and neck group meeting: "Euroscan, present status". September 1991, Düsseldorf, Germany. IV Symposium on Tumor Research in Oto-RhinoLaryngology: "Head and neck cancer risk assessment by biological markers". October 1991, Vittorio Veneto, Italy. Convegno Internazionale Il Carcinoma Faringo Laringeo:"Euroscan: Uno studio europeo sulla chemio-prevenzione dei secondi tumori primitivi". October 1991, Verona, Italy. Euroscan-meeting: "Euroscan, present status". October 1991, Baton Rouge, USA. Symposium on Vitamins and Cancer Prevention: "Euroscan, present status". March 1992, Amsterdam. 7th NCI-EORTC Symposium on new drugs in cancer therapy: "Intermediate endpoints in chemoprevention trials". - Dr. M.P. Copper, -5 - November 1992, Amsterdam. chemoprevention trials". NWHHT-conference: "Intermediate end-points in March 1993, Nijmegen. KNO-vergadering: "Erfelijke factoren spelen een belangrijke rol bij het ontstaan van het plaveisel-celcarcinoom in het hoofd-halsgebied: een patiëntcontrole-onderzoek". April 1993, Berlin, Germany. International Cancer Chemo Prevention Conference: "Intermediate markers in the Euroscan trial". May 1995, Brussels, Belgium. EORTC head and neck group meeting: "Biomarkers and their application in cancer chemoprevention". November 1996, Amsterdam. 9e symposium experimenteel onderzoek heelkundige specialismen: "Nieuwe risicofactoren voor het ontwikkelen van een plaveiselcelcarcinoom in het hoofd-hals gebied". January 1997, Haarlem. KNO-vergadering: “De percutane punctie-tracheotomie: Een beschrijving en analyse van twee verschillende methoden”. May 1998, Arcachon, France. 1st European week on the larynx: “Recurrent laryngeal nerve contribution in motor innervations of the human crico-pharyngeal muscle”. June 1998, Helsinki, Finland. 7th International congress of pediatric otorhinolarygology: “A new combined treatment of surgery, brachytherapy and reconstruction in children with recurrent rhabdomyosarcoma after chemotherapy: The AMORE-protocol”. September 1998, Rome, Italy. Second congress of the European Laryngological Society: “Recurrent laryngeal nerve contribution in motor innervations of the human cricopharyngeal muscle”. April 1999, Amsterdam. KNO-vergadering: “Biomarkers bij chemopreventie van tweede primaire tumoren in patiënten met een hoofd-hals carcinoom”. November 1999, Groningen. KNO-vergadering: “Laryngofaryngeale reflux bij patiënten met een carcinoom in het hoofd-hals gebied”. November 1999, Epe. Lustrummeeting Nederlandse Werkgroep Hoofd-Halstumoren: “Biomarkers bij chemopreventie van hoofd-hals tumoren: een update”. March 2001, Amsterdam. Refereeravond VUMC: “Chemopreventie bij het hoofdhalscarcinoom”. October 2001, Moerkapelle. Symposium “Larynxcarcinomen en spraakrevalidatie”. & Workshop OK-assistenten KNO: May 2002, Boca Raton, USA. American Head & Neck Society (Combined Otolaryngological Spring Meetings): “Foscan® mediated photodynamic therapy in early stage squamous cell carcinoma of the head and neck”. September 2002, San Diego, USA. American Academy of Otolaryngology - Head and Neck Surgery. Laryngopharyngeal Reflux: What to Do in the Normal ENT Practice (instructor). - Dr. M.P. Copper, -6 - November 2002, Amsterdam. KNO-vergadering:“Lange termijn resultaten van Foscan® gereguleerde fotodynamische therapie bij de behandeling van oppervlakkige hoofdhalscarcinomen.” November 2002, Rio de Janeiro, Brazil. 8th World Congress on Oral Cancer. Workshop Photodynamic Therapy (invited speaker). May 2003, Koln, Germany. Course on PDT (instructor) September 2003, Amsterdam. Course on PDT (instructor) July 2004, Amsterdam. NDDO-meeting: ”Recognizing patients who can benefit from PDT.” March 2005, Liverpool, England. Aintree Hospital: ”Head and Neck cancer treated by Photodynamic Therapy.” March 2005, UMCU. Refereeravond: ”De behandeling van hoofd-hals tumoren met photodynamische therapie.” November 2005, Nieuwegein. KNO-vergadering: ”Results of Foscan® mediated photodynamic therapy in the treatment of second primary tumors in the head and neck”. November 2006, Amsterdam. Opening PDT-centre: ”Photodynamic therapy and head and neck cancer”. January 2007, Dordrecht. Masterclass BAHA: ”Suturing and bandages”. March 2008, Nieuwegein. Sleepmarket 2008: ”De surgical treatment of OSAS”. January 2009, Nieuwegein. Department of surgery: ”Algorithm Neck node”. September 2010, Nieuwegein. Reflux course ATOS Medical: ”Techniques in measuring laryngopharyngeal reflux”. October 2010, Nieuwegein. Najaarsvergadering NSWO: ”Multilevel Surgery in untreated OSAS patients”. January 2013, Nieuwegein. BAHA Master class. Introduction and new developments. March 2015, Nieuwegein, National Symposium on Anaesthesia and OSAS. Surgical treatment options for OSAS. April 2015, Nieuwegein, NVTS (Dutch Society of Dental Sleep Medicine). New surgical treatment options for OSAS. October 2015, Veldhoven, Dutch Surgery Days. Hypoglossal nerve stimulation: a new surgical treatment option for OSAS. February 2016, Frankfurt, Germany. DISE for patient selection in UAS therapy. - Dr. M.P. Copper, -7 -