Download The Surgical Treatment of Bladder Cancer Jakko Nieuwenhuijzen

The Surgical Treatment
of Bladder Cancer
Jakko Nieuwenhuijzen
This study has been performed in The Netherlands Cancer Institute / Antoni van
Leeuwenhoek hospital, Amsterdam, the Netherlands.
ISBN: 978-90-8659445-0
The publication of this thesis was financially supported by: Abbott, Astellas,
AstraZeneca, CombiCare, Eli lilly, Eurocept, Ferring BV, GlaxoSmithKline, Hitachi,
Hoogland Medical, Medisch Centrum Alkmaar, Novartis, Nycomed, Olympus,
Pfizer, Pohl Boskamp, sanofi-aventis, de Vrije Universiteit, Zambon.
Cover design: Gryts Lootsma
Typography: Bruce Ross
Printed by: Buijten & Schipperheijn
VRIJE UNIVERSITEIT
The Surgical Treatment
of Bladder Cancer
ACADEMISCH PROEFSCHRIFT
ter verkrijging van de graad Doctor aan
de Vrije Universiteit Amsterdam,
op gezag van de rector magnificus
prof.dr. L.M. Bouter,
in het openbaar te verdedigen
ten overstaan van de promotiecommissie
van de faculteit der Geneeskunde
op woensdag 28 april 2010 om 11.45 uur
in de aula van de universiteit,
De Boelelaan 1105
door
Jacobus Adrianus Nieuwenhuijzen
geboren te Harderwijk
promotor: prof.dr. S. Horenblas
Voor mijn ouders
Contents
Chapter 1:
General introduction and outline of the thesis ...............................
9
Chapter 2:
Local recurrence after cystectomy and survival of bladder
cancer patients; a population based study in greater
Amsterdam (J urol, 174: 97, 2005)................................................
23
Neoadjuvant methotrexate, vinblastine, doxorubicin and
cisplatin for histologically proven lymph node positive bladder
cancer (J urol, 174: 80, 2005) .......................................................
39
Small cell carcinoma of the bladder: a single centre study
of 25 cases treated in analogy to small cell lung cancer
(Urology, 65: 295, 2005) ...............................................................
55
Survival after bladder preservation with brachytherapy
versus radical cystectomy; a single institute experience
(Eur urol, 48: 239, 2005) ...............................................................
67
Salvage cystectomy after failure of interstitial radiotherapy and
external beam radiotherapy for bladder cancer
(BJU int, 94: 793, 2004) ................................................................
85
Clinical outcomes after sexuality preserving cystectomy and
neobladder (prostate sparing cystectomy) in 44 patients
(J urol 173: 1314, 2005; J urol 179: S35, 2008) ............................
99
Chapter 3:
Chapter 4:
Chapter 5:
Chapter 6:
Chapter 7:
Prostate sparing cystectomy: long term oncological results
(BJU int, 104: 1239, 2009) ............................................................ 111
Chapter 8:
Urinary diversions after cystectomy: the association of
clinical factors, complications, and functional results of 4
different diversions (Eur urol 53: 834, 2008) ................................. 123
Chapter 9:
Follow-up after cystectomy: regularly scheduled, risk adjusted,
or symptom guided? Patterns of recurrence, relapse
presentation, and survival after cystectomy (submitted) .............. 137
Chapter 10:
General discussion and future perspectives ................................. 153
Chapter 11:
Summary / Samenvatting.............................................................. 167
Dankwoord ............................................................................................................ 179