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Volume 14, Number 3, Autumn 2009
Report of Scientific Congresses, Abstracts of Other Articles and ...
Description:
"Case Report" Cytomegalovirus Colitis with similar Endoscopic Pattern of
Pseudomembranous Colitis in Collagen Vascular Disease
Description: Pashaei M, Ebrahimi-Daryani N, Ajdarkosh H, Ameli M ..... ABSTRACT .....
Cytomegalovirus (CMV) infection can cause colitis which is usually manifested with fever,
weight loss, anorexia and abdominal pain.Watery diarrhea can be the only manifestation.
CMV colitis usually can not be diagnosed according to the clinical findings. Moreover,
endoscopic appearance can exactly mimic pseudo-membranous colitis. Here by, we are
presenting a patient with fever and watery diarrhea receiving immunosuppressive treatment
due to rheumatoid arthritis who had received antibiotics. Pseudo-membranous colitis was
revealed during colonoscopy and subsequently metronidazole and vancomycine treatment
initiated but no improvement was observed. Finally, according to the positive CMV antibody
and the presence of CMV antigen diagnosis was confirmed and valganciclovir for CMV colitis
was administered. Keywords: Cytomegalovirus coliti ,Pseudo-membranous colitis,
Valganciclovir Govaresh/ Vol. 14, No.3, Autumn 2009; 164-169 Corresponding author:
Second floor of Jam-E-Jam, No. 130, Next to Zafar Cross, Vali-E-Asr Ave, Tehran, Iran Tel:
+98 21 88799446 Fax: +98 21 88799840 Email: [email protected] Received: 5 Jul. 2009
Edited: 23 Feb. 2010 Accepted: 23 Feb. 2010
"Case Report" Diagnosis of a rare syndrome: Cronkhite-Canada syndrome
Description: Vahedi H, Arab P ..... ABSTRACT ..... Cronkhite-Canada syndrome (CCS) is a
rare, non-familial disorder of unknown etiology associated with alopecia, cutaneous
hyperpigmentation, gastrointestinal polyposis, onychodystrophy, diarrhea, weight loss and
abdominal pain. The prevalence of gastrointestinal malignancy in CCS patients is about 13%,
and especially is high in colorectal and gastric areas; 5 year mortality rate is 55%. In this
report, a 74 year old man is described who had dysgeusia, skin hyperpigmentation,
onycholysis, abdominal pain, chronic diarrhea, progressive weight loss and episodic melena
since one year ago. He underwent upper endoscopy and colonoscopy. Diffuse polyposis were
seen in stomach, duodenum and from rectum to cecum. Pathology of biopsy specimens
showed hamartomatous polyps, compatible with Cronkhite-Canada syndrome.Although CCS
is a rare acquired syndrome, it should be considered in differential diagnosis of gastrointestinal
polyposis with diarrhea and skin changes. These patients need careful follow up to identify
associated malignancies. Keywords: Cronkhite-Canada syndrome, Hamartomatous Polyps,
Non-Familial Govaresh/ Vol. 14, No.3, Autumn 2009; 161-163
"Case Report" Good Prognosis of Early stage Malignant Melanoma of the Esophagus
Description: Zare-Mehrjardi A, Vahedian-Ardakani J ..... ABSTRACT ..... Malignant
melanoma of the esophagus is a rare tumor with poor prognosis. The survival of patients is
generally less than one year after diagnosis. A case of primary malignant melanoma of the
esophagus is presented, who after radical resection of the tumor, is in excellent health, with no
evidence of disease 14 months after surgery. Keywords: Melanoma, Esophagus, Esophageal
tumor Govaresh/ Vol. 14, No.3, Autumn 2009; 203-204 Corresponding author: Department of
Pathology, Firoozgar Hospital, Beh-Afarin st, Vali-e-asr sq., Tehran, Iran Tel:+98 21
88942661-4 Fax: +98 21 88942622 E-mail: [email protected] Received:31 May
2009 Edited: 28 Jul. 2009 Accepted: 29 Jul. 2009
"Original Article" Primary Non-Hodgkins Lymphoma of the Pancreas How can
Differentiate it from pancreatic Adenocorcinoma?
Description: Sotoudehmanesh R, Bakhshipour AR, Zamani F, Rakhshani N, Zenali F .....
ABSTRACT ..... Background: Primary pancreatic lymphoma (PPL) is a rare condition and its
differentiation from most commonly adenocarcinoma is very important because of different
prognosis and treatment strategies. The aim of this study was presenting different aspects for
differentiating PPL from pancreatic adenocarcinoma. Materials andMethods: During 14
months, 5 patients who underwent endoscopic ultrasonography in our ward were recorded.
Demographic characteristics, laboratory and imaging findings were evaluated. Literature
review was done. Results: The duration of symptoms was between one to two months. The
primary presenting symptoms were abdominal pain, weight loss, jaundice and pruritus. All
patient except one, diagnosed as primary pancreatic lymphoma by EUS-guided fine-needle
aspiration. Occasional presence of B-symptoms, larger size of the lesion, less occurrence of
invasion to the large vessels despite larger size, less occurrence of obstructive jaundice (in
spite of greater frequency in the head of the pancreas) and normal or lower titer of CA19-9
may be useful keys for differentiating primary pancreatic lymphoma from pancreatic cancer.
Conclusion: Although cytology or tissue histology is fundamental for the diagnosis, clinical,
laboratory and imaging findings may be valuable tools for differentiation PPL from pancreatic
adenocarcinoma. Keywords: Non-Hodgkin Lymphoma, Diagnosis, Histology Govaresh/ Vol.
14, No.3, Autumn 2009; 198-202 Corresponding author: Digestive Disease Research Center,
Tehran University ofMedical Sciences, 14117-13135-North Kargar Ave., Shariati hospitalTehran-Iran Tel: +98 21 82415000 Fax: +98 21 82415400 E-mail: [email protected]
Received: 22. Jul. 2009 Edited:10 Oct. 2009 Accepted: 15 Oct. 2009
"Original Article" Pancreatic concer: State of the Art and Current Situation in the
Islamic Republic of Iran
Description: Jamali A, Kamgar M , Massarrat S, Sotoudeh M, Larijani B, Adler G, Seufferlin
T ..... ABSTRACT ..... Compared to western countries, pancreatic cancer has a relatively low
incidence in Iran. It is rarely diagnosed before the fifth decade in Iran and most of the patients
are older than 60 at the time of diagnosis like to the western countries, where pancreatic cancer
is a disease of advanced age. The incidence of the disease in some young patients suggests a
possible role of genetic defects, which is probably due to high consanguineous marriages in
Iran. Despite many efforts in improving diagnosis and treatment of pancreatic cancer, this
disease has still dismal prognosis. The analysis of the spatial spread of the pancreatic cancer in
Mazandaran and Golestan, two provinces in the Caspian Sea region in the north of Iran, which
comprise a low incidence of pancreatic cancer, showed that the disease, unlike other
gastrointestinal tract cancers, does not exhibit high incidence clusters in the region. Our
knowledge about the molecular and cellular pathology of the pancreatic cancer has progressed,
and many agents including anti-EGFR, anti-VEGF, and immunotherapeutic agents have been
applied for the treatment of the disease. However, surgery remains the only curative approach
and further research is paramount to identify novel diagnostic and predictive biomarkers for
early diagnosis and treatment stratification. Pancreatic cancer requires an interdisciplinary
approach which involves surgery, pathology, radiology, gastroenterology, oncology, and
palliative care provided in dedicated, specialized centers. Govaresh/ Vol. 14, No.3, Autumn
2009; 189-197 Corresponding author: Department of Internal Medicine, Martin Luther
University Halle-Wittenberg, Ernst-Grube-Strasse 40, D-06120 Halle/Saale, Germany. Tel:
+49 345 5572661 Fax: +49 345 557 E-mail: [email protected]
Received: 9 Dec. 2009 Edited: 2 Jan. 2010 Accepted: 3 jan. 2010
"Original Article" Detection of Hepatitis G Virus (GBV-C) in chronic Hepatitis C
Patient by RT-Nested PCR
Description: Ghanbari R, Ravanshad M, Hosseini SY, Shahzamani K ..... ABSTRACT .....
Background: Hepatitis G virus (GBV-C) is a single strand RNApositive virus and is a member
of flaviviridae family. Infection with the virus is prevalent add has worldwide distribution.
Accurate diagnosis of the virus is very important, because of co-infection with other important
viruses like HCV, HBV and HIV, it may influence on pathogenesis, disease progression and
response to viral therapy. Materials and Methods: In the current investigation a sensitive and
accurate RT-Nested PCR for isolation and detection of 5'-UTR sequences of Hepatitis G virus
(GBV-C) was developed and applied. First genome of the virus was extracted and then, by
Reverse Transcription method, cDNA was synthesized. Then, by use of a double stage PCR
and two pairs of specific primers, the specified region of the virus genome was amplified and
the final product was visualized on agarose gel electrophoresis. Results: Based on five positive
samples, the method was developed and optimized. Then, by use of the developed method, 71
sera samples from chronic HCV infected patients, was checked for Hepatitis G virus (GBV-C).
Finally, it was shown that 31(43.6%) patients were positive for Hepatitis G virus. Conclusion:
Based in the results in the current study, it was shown that the developed assay has acceptable
performance for diagnosis of Hepatitis G virus infection.Also it was concluded that the
infection rate among chronic HCV infected patients is high. Keywords: Nested PCR, RT-PCR,
Hepatitis G virus, 5’-UTR Govaresh/ Vol. 14, No.3, Autumn 2009; 153-160
Corresponding author: Department of Virology, Faculty of Medical Sciences, Tarbiat Modares
University, Tehran, Iran Telefax : +98-21-82883836 E-mail: [email protected]
Received: 16 Dec. 2009 Edited: 22 Feb. 2010 Accepted: 23 Feb. 2010
"Original Article" Immunohistochemistry stain Assessment of DNA Mismatch Repair
Proteins in Gastric Cancer
Description: Molaei M, Yadollahzadeh M, Mansoori B, Nemati F, Zali N, Montazer-Haghighi
M, Zali MR ..... ABSTRACT ..... Background: Germline mutations in MMR genes are
reported to be present in more than 70% of HNPCC cases. But, there is a paucity of data
regarding the importance of defect of MMR system in the gastric cancer in general. So, in this
study, we used IHC stain forMLH1,MSH2, PMS2 andMSH6 to reveal profile ofMMR
expression in patients with gastric cancer. Materials and Methods: This study was performed
on 134 patients with gastric cancer who had undergone surgical resection from January 2001
to December 2005. For comparative analyses chi-square test or Fisher’s exact test and ttest were used. Results: Through IHC assay, all of samples from patients had normal stain for
MSH2 and MSH6. Except in 5 cases (3.7%) IHC stains for MLH1 and in 4 cases (3%) IHC
stains for PMS2 were normal. In comparative analyses there were not any significant
difference in variables between subgroups of IHC result. Conclusion:Although, genetic factors
are cause of gastric cancer in few patients, and germline mutation may increase the risk of
gastric cancer. In this study 3.7% of cases with gastric cancer had abnormalMMR proteins
function. It seems that MLH1 and PMS2 have a major role in MMR functions in Iranian
patients with gastric cancer, to further clarify this issue, more resrarchers should be done.
Keywords: Mismatch repair system, Immunohistochemistry, Gastric cancer, MLH1, PMS2,
MSH2, MSH6. Govaresh/ Vol. 14, No.3, Autumn 2009; 148-152 Corresponding author:
Gastroenterology and Liver Disease Research Center, Shahid Beheshti University of Medical
Sciences, Tehran, Iran Tel: + 98 21 22432515 Fax: + 98 21 22432517 E-mail:
[email protected] Received: 19 Oct. 2009 Edited:7 Feb. 2010 Accepted: 9 Feb. 2010
"Original Article" Seroepidemiology and Determination of Age trend of Helicobacter
Pylori Contamination in Golestan province in 2008
Description: Ghasemi-Kebria F, Asmar M, Angizeh AH, Behnam-Pour N, Bazouri M, Tazike
E, Ghaemi EA ..... ABSTRACT ..... Background: Infection with Helicobacter pylori might be
related to chronic gastritis, peptic ulcer and gastric Adenocarcinoma. Given the high
prevalence of Helicobacter infection in our region, this study was designed to determine the
age trend of Helicobacter pylori contamination in Golestan province in 2008. Materials
andMethods: This cross-sectional descriptive study was carried out on 1028 residents of
Golestan province, which were randomly selected by cluster sampling in 2008. Data were
gathered by questionnaires and trial examinations. Blood sampling and titration of anti-H
pylori IgG by ELISAwere done. SPSS software was used for statistical analysis of the results
and was considered significant (P