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Dr. KK Rana, Asstt. Professor (Stage-3), Gushkara Mahavidyalaya GENERAL INFORMATION 1. Name: Dr. Kalyan Kumar Rana 2. Father’s name: Late Sudhir Chandra Rana 3. Department: Department of Chemistry 4. Current Designation: Assistant Professor (Stage-3) 5. Address for correspondence : Dr. Kalyan Kumar Rana Opp-Puratanchak Ration Shop, PO-Nutanganj Sher Afghan Road, PS+Dist-Burdwan PIN-713102, WB. 6. Permanent Address (with pin code): Dr. Kalyan Kumar Rana Opp-Puratanchak Ration Shop, Sher Afghan Road, PO-Nutanganj PS+Dist-Burdwan, PIN-713102, WB. 7. Educational Qualification (Graduation onwards): Examination BSc MSc PhD(Sc) Name of the Affiliating University Vidyasagar University Vidyasagar University Jadavpur University Year of passing 1994 1996 2002 NET GATE --- 2000 (June) 1996 and 1997 Name of Institution Pravat Kumar College, Contai Vidyasagar University, MIdnapore Indian Association for the Cultivation of Science, Jadavpur ----- Some Presentable Information Dr. KK Rana has joined in the Gushkara Mahavidyalaya on 01.03.2003 as a Lecturer in Chemistry and continuing till date as an Associate Professor (Stage-3) of Chemistry. JRF, SRF and RA(I) at Indian Association for the Cultivation of Science, 2A, 2B Raja SC Mallick Road, Jadavpur, Kolkata-32. Post Doctoral Research Associate at North Dakota State University, North Dakota, USA, under the supervision of Prof. MP Sibi, Dept. of Chemistry and Biochemistry. Attended one ‘Orientation Programme’ and three ‘Refresher Courses’ specified for College Teachers, Organized by the UGC-Academic Staff College, The University of Burdwan. Attended Seven Retraining Programmes of College Teachers, organized by Jadavpur University, Jadavpur, Kolkata, under UGC-JU Potential for Excellence Scheme. Attended a number of Seminars, Symposia, Conferences Summer and Winter Schools etc. related to Chemistry. Published 17 Research Papers in Internationally Reputed Journals. Published 2 Text Books on UG Chemistry Practical Courses. Published 2 Edited Volumes. Obtained Silver Medal from Vidyasagar University as stood second in 1996 MSc (Chemistry) batch. Regarding Research: Have Ability to perform synthetic organic chemical reactions and to purify the products in micro scale. Expertise in handling air and moisture sensitive compounds like epoxides, bromides, epoxyolefinic compounds etc. Experience in analysis of 1H, 13C, DEPT NMR and mass spectra. Interpretation of GC-MS, EI-MS, GC, paper chromatography and handling HPLC, FT-IR etc. Working knowledge in MSWord, MSPowerPoint, MSExcel, ChemWindow, Chemdraw, Chemoffice etc. Obtained a Minor Research Project Proposal to UGC, ERO. Title of the project is “Development of an efficient and convenient protocol for the synthesis of polyfunctionalized benzopyrans by a three-component one-pot coupling reaction using molybdenylacetylacetonate as the catalyst” Life Member: Indian Association for the Cultivation of Science, Jadavpur, Kolkata-32 [Mem. No. 3687/17-4-97]. Member: Indian Chemical Society, 92 APC Road, Kolkata-9 [Mem. No. 5811]. Life Member: The Indian Science Congress Association, 14, Dr. Biresh Guha Street, Kolkata-17 [Mem. No. L21169]. Life Member: Indian Science News Association, 92, APC Roy Road, Kolkata-9 [Mem. No. LM 805]. Life Member: Udbodhan, 1, Udbodhan Lane, Baghbazar, Kolkata- 3 [Mem. No. LK312P] Participation in Seminars, Conferences etc. Sl. No. Name of OP/RC/Workshop/ Seminar/Symposia Organized by Venue Date 1. 56th Orientation Programme UGC-ASC, Burdwan University UGC-ASC, Burdwan University 21st Dec., ’05 17th Jan., ’06 2. Empowerment of Women MUC Women’s College, Burdwan MUC Women’s College Burdwan 24th & 25th Feb., 2005 3. 3rd Chemical Research Society of India Symposium IIT, Kharagpur 6th Aug., 2005 4. 42nd Annual Convention of Chemists 9th-13th Feb., 2006 5. Retraining of College Teachers on Development of Scientific Awareness Jadavpur University 6. Retraining of College Teachers on “Placement Network Management” Jadavpur University Dept. of Chemistry Visva Bharati Santiniketan Dept. of Instrumentation Engineering, Jadavpur University Dept. of Mechanical Engineering, Jadavpur University 7. 4th Chemical Research Society of India Symposium Chemical Research Society of India and Dept. of Chem. Kalyani University Chemical Research Society of India and Department of Chemistry, IIT, Kharagpur Indian Chemical Society and Department of Chemistry, Visva Bharati, Santiniketan Kalyani University University College of Science and Technology, University of Calcutta, Rajabazar, Kolkata-9. Department of Power Engg. Jadavpur University. 10th -11th Mar., 2006 21st Mar., 2006 4th Aug., 2006 8. Acharya Prafulla Chandra Ray and Chemistry Today Indian Chemical Society 9. Retraining of College Teachers on “Placement Office Management” Jadavpur University 10. International Symposium on Current Perspectives in Organic Chem. Dept. of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur MLS Hall, IACS, Jadavpur Kol-32 7th-9th Dec., 2006 Jadavpur University Dept. of Mech. Engg., Jadavpur University 5th Jan., 2007 Jadavpur University Dept. of Mathematics, Jadavpur University 16th Jan. 2007 Dept. of Mathematics, Jadavpur University Dept. of Architecture, Jadavpur University Raj College, Burdwan 19th Jan. 2007 11. 12. 13 14 15 Retraining of College Teachers on “Science Education and Development of Scientific Bent of Mind.” Retraining of College Teachers on “Scope of Research in Science and Engineering.” Retraining of College Teachers on “Computer Aided Teaching.” Retraining of College Teachers on “Redesigning of an Existing Syllabus.” The proposed Indo-US Nuclear Treaty: Implication Jadavpur University Jadavpur University WBCUTA, Burdwan Distt.. Committee 15th Sep., 2006 24th Nov., 2006 5th Feb. 2007 8th Dec., 2007 and Significance 16 17 18 19 20 21 22 UGC-Sponsored National Seminar on “Advanced Spectroscopy, Theoretical Chemistry, Synthesis, Reactivity and Structure Evaluation.” Summer School on “Corrosion Fundamentals, Testing and Prevention.” Seminar on “Education: Past and Present” 15th Refresher Course on Environmental Science Winter School on “Waste Mgmt., Effluent Treatment and Recycling.” UGC Sponsored State Level Seminar on “Tourism: An Activity for Economic and Socio-Cultural Boost” UGC Sponsored State Level Seminar on “Bio-Diversity: Issues and Concerns” 23 ‘Prabodh’ Certificate Course in Hindi 24 National Workshop on SCILAB 25 26 27 UGC and State DST Sponsored National Seminar on “Design, Synthesis, Interaction, Chemical and Biochemical Activities of Different Functional Molecules” Chemical Research Society of India Symposium on “Chemical Research in the First Decade of 21st Century” 20th Refresher Course on Environmental Science 28 Science Academies’ Lecture Workshop on “Recent Developments in Chemistry” 29 UGC Sponsored National Level Seminar on “Advanced Instruments used in Current Research” 30 UGC Sponsored National Level Seminar on “Frontier in Chemistry” The University of Burdwan, Dept. of Chemistry Deptt. of Chemistry 25th-27th Apr., 2008 MHRD/AICTE under Staff Dev. Programme Dept. of Chemistry, NIT, Durgapur 14th to 27th July, 2008 Gushkara Mahavidyalaya UGC-ASC, Burdwan University 25th Sept., 2008 MHRD/AICTE under Staff Dev. Programme Dept. of Chemistry, NIT, Durgapur 19th to 31st Jan., 2009 Gushkara Mahavidyalaya and BN Dutta Smriti Mahavidyalaya, Burdwan Gushkara Mahavidyalaya 26th March, 2010 Gushkara Mahavidyalaya 27th March, 2010 Distance Mode November, 2010 Haldia Institute of Technology, Haldia 27th-29th Dec., 2010 Deptt. of Chemistry 15th-17th March, 2011 Gushkara Mahavidyalaya UGC-ASC, Burdwan University Gushkara Mahavidyalaya and BN Dutta Smriti Mahavidyalaya, Burdwan Hindi Teaching Scheme (Exam. Wing), Department of Official Language, Ministry of Home Affairs, Govt. of India School of Applied Sciences and Deptt. Information Technology, HIT Haldia and FOSSEE—Project of IIT Bombay The University of Burdwan, Deptt. of Chemistry Chemical Research Society of India and Department of Chemistry, Visva Bharati, Santiniketan UGC-ASC, Burdwan University Department of Chemistry, Visva Bharati, Santiniketan Department of Chemistry & Physics, Dept. of Sri Ramakrishna Sarada Vidya Mahapitha, Kamarpukur and Dept. of Physics, The University of Burdwan Department of Chemistry, MUC Women’s College and Department of Chemistry, Vivekananda Mahavidyalaya, 23rd Dec.,’08 12th Jan., ’09 Department of Chemistry, Visva Bharati, Santiniketan UGC-ASC, Burdwan University Department of Chemistry, Visva Bharati, Santiniketan 15th Oct.- 04th Nov., ’11 Sri Ramakrishna Sarada Vidya Mahapitha, Kamarpukur 20th-21st Sept., 2013 MUC Women’s College 4th-5th Dec., 2013 6th Aug., 2011 29th Nov.-1st Dec., 2012 Burdwan Department of Chemistry, Visva Bharati, Santiniketan Department of Chemistry, Visva Bharati, Santiniketan 31 Science Academies’ Lecture Workshop on “Recent Developments in Chemistry” Department of Chemistry, Visva Bharati, Santiniketan 32 National Seminar on “Recent Advances in Chemistry” Department of Chemistry, Visva Bharati, Santiniketan 33 National Symposium on “Recent Advances in Chemistry and Industry (2014)” Indian Chemical Society, Kolkata Meghnad Saha Bhavan, 92, APC Road, Kolkata-9 1st-2nd Aug., 2014 34 National Symposium on “Opportunities in Medicinal Plant Research” Society for Ethnopharmacology and School of Natural Product Studies, Jadavpur University Gandhi Bhavan, Jadavpur University, Jadavpur, Kolkata32 29th-30th Nov., 2014 Sitananda College, Nandigram and Royal Society of Chemistry (Eastern India Section) Sitananda College, Nandigram, Purba Medinipur 12th Dec., 2014 UGC-ASC, Burdwan University UGC-ASC, Burdwan University 24th-30th Dec., 2014 UGC-ASC, Burdwan University UGC-ASC, Burdwan University 30th Jan.- 19th Feb., 2015 Dept. of Chemistry, Gushkara Mahavidyalaya, Gushkara, Burdwan SN Bose Hall, Gushkara Mahavidyalaya 22nd March, 2015 Department of Chemistry, Haldia Govt. College, Haldia, Purba Medinipur Auditorium, Haldia Govt. College, Haldia, Purba Medinipur 4th - 5th August, 2016 35 36 37 38 39 National Symposium on “Chemistry and its Interface with the Scientific Disciplines” 2nd Short Term Course on “Students’ Counseling and Guidance” 1st RC in “History of Science and Technology” UGC sponsored UGC sponsored National Seminar on “Recent Developments in Green Chemistry” UGC sponsored two day National Seminar on “Recent Development in Bio-Active Molecules (RDBAM-2016)” 17th-18th Feb., 2014 9th March, 2014 Areas of Interest Synthetic Organic Chemistry, especially, radical cyclisation using a transition metal radical source and related methodology. Wrote few Review Papers on Microwave Assisted Organic Synthesis, Green Chemistry, Medicinal Usefulness of Vitex negundo Linn., Herbal Medicine etc. Also wrote two text books on Practical Chemistry of Hons./Gen. Course and Practical Chemistry of Engineering Course and published two edited volumes. List of Publications Books: i. Text Book on Undergraduate Chemistry Practical Courses, Dr. KK Rana, Bhasa O Sahitya, Kolkata, (Dec., 2011), ISBN: 978-81-8438-054-2 ii. Text Book on Chemistry Practical for Engineering Courses, Dr. KK Rana ad Dr. S Rana, Bhasha o Sahitya, Kolkata, (Jan., 2015), ISBN: 978-81-8438-078-X iii. Proceedings of the Golden Jubilee (1965-2015) Celebration of Gushkara Mahavidyalaya, Edited Volume, (Aug., 2015), ISBN: 978-93-5235-350-7 iv. Proceedings of the UGC Sponsored National Seminar on “Recent Developments in Green Chemistry”, Edited Volume, (Aug., 2015), ISBN: 978-93-5235-543-3 Papers: 1). “A Mild and Efficient Method for the Deoxygenation ofEpoxyketones to Enones.” KK Rana and SC Roy; J. Ind. Chem. Soc., 1999, 76, 545. 2). “A Short and Stereoselective Total Synthesis of (±)-Sesamin by Radical Cyclisation of an Epoxide Using a Transition Metal Radical Source.” KK Rana, C Guin and SC Roy; Tetrahedron Lett., 2000, 41, 48, 9337. 3). “Ceric Ammonium Nitrate Mediated Selective Bromoalkoxylation of Activated Cinnamyl Compounds Using Lithium Bromide.” KK Rana, C Guin and SC Roy; Synlett, 2001, 2, 226. 4). “Synthesis of Spirocyclic Ethers by Radical Cyclisation of Epoxides Using a Transition Metal Radical Source.” KK Rana, C Guin and SC Roy; Ind. J. Chem., 2001, 40B, 925. (Dedicated to Prof. UR Ghatak on the occasion of his 70 th birth anniversary) 5). “Short and Stereoselective Total Synthesis of (±)-Dihydrosesamin and (±)-Acuminatin Methyl Ether by Radical Cyclisation of Epoxides Using a Transition Metal Radical Source.” KK Rana, C Guin and SC Roy; Synlett, 2001, 8, 1249. 6). “An Efficient Chemo- and Regioselective Oxidative Nuclear Bromination of Activated Aromatic Compounds Using Lithium Bromide and Ceric Ammonium Nitrate.” SC Roy, C Guin, KK Rana and G Maiti; Tetrahedron Lett., 2001, 42, 6941. 7). “Stereoselective Synthesis of Trisubstituted Tetrahydrofurans by Radical Cyclisation Reaction Using a Hypophosphite Salt. Application to the Total Synthesis of (±)Dihydrosesamin.” SC Roy, C Guin, KK Rana and G Maiti; Tetrahedron, 2002, 58, 2435. 8). “Short and Stereoselective Total Synthesis of Furano Lignans (±)-Dihydrosesamin, (±)Lariciresinol Dimethyl Ether, (±)-Acuminatin Methyl Ether, (±)-Sanshodiol Methyl Ether, (±)Lariciresinol, (±)-Acuminatin, (±)-Lariciresinol Monomethyl Ether and Furofuran Lignans (±)Sesamin, (±)-Eudesmin, (±)-Piperitol Methyl Ether, (±)-Pinoresinol, (±)-Piperitol, (±)- Pinoresinol Monomethyl Ether by Radical Cyclisation of Epoxides Using a Transition Metal Radical Source” SC Roy, KK Rana and C Guin, J. Org. Chem., 2002, 67, 10, 3242. 9). “A Novel and Efficient Ceric Ammonium Nitrate Catalysed Oxidative Nuclear Chlorination of Activated Aromatic Compounds by Acetyl Chloride.” SC Roy, KK Rana, C Guin and B Banerjee, Synlett., 2003, 2, 221. 10). “A Mild and Efficient Method for the Protection of Carbonyl Compounds as Oxathiolanes, Dithiolanes and Dithianes Catalyzed by Molybdenylacetylacetonate.” KK Rana, C Guin, S Jana and SC Roy, Tetrahedron Lett., 2003, 44, 8597. 11). “Ceric Ammonium Nitrate Catalyzed Mild and Efficient -Chlorination of Ketones by Acetyl Chloride.” SC Roy, KK Rana, C Guin and B Banerjee, ARKIVOK, 2003, (ix), 34. (Dedicated to Prof. Asima Chatterjee on the occasion of her 85th birth anniversary.) 12). Mild and Efficient Molecular Iodine Catalyzed Protection of Carbonyl Compounds as Oxathiolane Derivatives.” KK Rana, C Guin, B Banerjee and SC Roy, J. Ind. Chem. Soc., 2003, 80, 1005. (Dedicated to Prof. SM Mukherjee.) 13). “A review on Indian Women Scientists”, K.K. Rana and S. Rana, Communique (ISSN: 0973-8584), 2014, March, 8(1), 93-98. 14). “Review on Medicinal Usefulness of Vitex negundo Linn.” S. Rana and K.K. Rana, Open Access Library Journal (ISSN: 1234-1010), 2014, 1(3), 1-13. http://dx.doi.org/10.4236/oalib.1100508 15). “Review on Present Status and Future of Herbal Medicine”, K.K. Rana and S. Rana, The Beats of Natural Sciences (ISSN: 2348-7615), 2014(June), 1(2), 1-8. 16). “Fundamentals, Representative Applications and Future Perspectives of Green Chemistry: A Short Review” K.K. Rana and S. Rana, Open Access Library Journal (ISSN: 1234-1010) 2014, 1(5), 1-16. http://dx.doi.org/10.4236/oalib.1100748 17). “Microwave Reactors: A Brief Review on Its Fundamental Aspects and Applications” K.K. Rana and S. Rana, Open Access Library Journal (ISSN: 1234-1010) 2014, 1(6), 1-20, http://dx.doi.org/10.4236/oalib.1100686 Paper wise Syllabus Taught UG HONOURS COURSE BSc Part-I Chemistry (Hons.) Paper II Full Marks: 50 ORGANIC CHEMISTRY (THEORY) 1. General introduction (4 lectures) Nomenclature of organic molecules with special reference to polycyclic, bridge head, aromatic, heteroaromatic and heterocycles compounds, molecular weight (preliminary idea about mass spectroscopy), molecular formula 2. Structure and properties (8 lectures) Nature of bonding in aliphatic, alicyclic, aromatic and heterocyclic compounds; bond length, bond strength, bond angle and their variations in compounds with sp3, sp2 and sp hybridized carbon atoms; orbital pictures of methane, ethane, ethene, ethyne, allene and benzyne; delocalised bonds, resonance, steric inhibition of resonance, hyperconjugation, tautomerism, aromaticity, Huckel’s rules, aromatic, nonaromatic and antiaromatic compounds, non-benzenoid aromatic compounds, Huckel’s rule Inductive and field effects; dipole moment, H-bonding and its effect on physical and chemical properties of organic molecules 3. Introduction to organic reactions (7 lectures) Homolysis and heterolysis of bonds; types of reactions: ionic, radical and pericyclic; Bronsted-Lowry concept, Lewis concept, strengths of acids and bases; effect of solvent on acidity and basicity; relationship between structure and acidity and basicity, acid-base reactions Thermodynamics and kinetics of organic reactions, energy profiles for one-step and two- step reactions, catalyzed reactions, Hammond postulate, principle of microscopic reversibility, kinetically and thermodynamically controlled reactions; methods of determination of organic reactions: study of intermediates, kinetic and stereochemical studies, non-kinetic and kinetic studies with isotopes (primary and secondary kinetic isotope effects), crossover experiments 4. Reactive intermediates (8 lectures) Formation, structure, stability and reactions of classical and non-classical carbocations, carbanions, free radicals, arynes, ylides, carbenes and nitrenes 5. Stereochemistry (20 lectures) Concept of constitution, stereochemical representation: Fischer, Newman, Sawhorse, Flying-wedge and their interconversions, molecular symmetry: plane, centre, simple and alternating axes; symmetry operations, chirality and chiral centre, configuration, configurational nomenclature: D/L, R/S, erythro/threo; optical activity and optical isomerism, optical rotation: specific and molecular; optical purity, enantiomeric excess; resolution of optical isomers; chiral axis in allenes, biphenyls and spiranes and their R/S descriptors Geometrical isomerism (diastereomerism) of molecules with C=C, C=N (oximes) and simple cyclic molecules; cis/trans and E/Z nomenclature Conformation of alkanes and cycloalkanes: dihedral angle and angle of torsion, gauche, eclipsed and staggered arrangements; synperiplanar, synclinal, anticlinal, antiperiplanar conformations; conformation-energy diagram of ethane, propane and n-butane, relative stability of conformers on the basis of steric effect, dipole-dipole interaction, H-bonding; conformational analysis of cyclohexane and its mono- and di-substituted derivatives with chair, boat and twist boat forms and their symmetry properties and optical activity; strains in molecules: angle, bond, torsional and steric; steric and stereoelectronic factors. 6. Aliphatic nucleophilic substitution reactions (8 lectures) Free radical and nucleophilic substitutions at sp3 carbon: SN1, SN2, SNi SN1′, SN2′, SNi′ reactions; NGP Factors affecting rates of SN1 and SN2 reactions, phase transfer catalyst and its use in organic reaction, use of crown ether in substitution reaction; functional group transformations using S N2 reactions 7. Elimination reactions (5 lectures) E1, E2 and E1CB mechanisms, reactivity, Saytzeff/Hofmann orientation and stereoselectivity; elimination Vs substitution; syneliminations: pyrolysis of ester, xynthate, tert-N-oxide. BSc Part-I Chemistry (Hons.) Paper IV Full Marks: 50 ORGANIC CHEMISTRY (PRACTICAL) Organic Qualitative analysis (30 marks) Recording of physical characteristics (colour, texture, odour and melting point) Preliminary tests (ignition test, soda lime test, litmus test, unsaturation test, Beilstein test) Lassaigne’s test (detection of special elements N, S, halogens) Solubility classification (H2O, 5% HCl, 5% NaOH, 5% NaHCO3, conc. H2SO4, conclusion) To be recorded in a tabular form) Functional group detection [Nitrogen containing: aromatic -NH2 and -NO2, -CONH2, CONHAr; non-nitrogenous: phenolic -OH, -COOH, -CO- (aldehydic or ketonic), -CO2R] Literature survey (selection of suitable derivative) Derivative preparation (procedure and recording of melting point) Conclusion Organic preparation (10 marks) (A) Condensation: preparation of phthalimide (B) Nitration: nitration of nitrobenzene, acetanilide (C) Oxidation: oxidation of benzyl chloride/benzyl alcohol, benzoin (D) Acetylation: acetylation of aniline using glacial acetic acid (E) Hydrolysis: hydrolysis of amide/imide, esters (F) Bromination: bromination of acetanilide using KBr, KBrO3 and glacial acetic acid LNB (5 marks) Viva-voce (5 marks) BSc Part-II Chemistry (Hons.) Paper VI Full Marks: 50 ORGANIC CHEMISTRY (THEORY) 1. Stereochemistry (4 lectures) Stereogenecity, chirotopicity, achirotopicity, prochirality, topicity of ligands and faces (Pro-R, Pro-S and Re/Si designations), chemoselective, regioselective, steroselective: diasteroselective, enantioselective reactions with examples. Asymmetric synthesis: Cram’s rule 2. Electrophilic and radical addition to C-C multiple bonds (4 lectures) Halogenation, hydrohalogenation, hydration, hydrogenation, epoxidation, hydroxylation, ozonolysis, 1,3dipolar additions; electrophiilic addition to conjugated dienes and allenes; radical addition addition of HBr; reduction of alkynes and bezenoid aromatics Diels-Alder reaction, addition of carbenes 3. Nucleophilic addition to carbonyl group (10 lectures) Reactions with water, alcohols, amines, thiols, HCN, bisulfite, Wittig reaction, Meerwein-Pondorf- Varley reduction, reduction with lithium aluminum hydride and sodium borohydride, Wolff-Kishner reduction, Clemmensen reduction, Bouveault-Blanc reduction, addition of organometallics, addition of diazomethane, Cannizzaro reaction, aldol condensation including directed aldol reaction, Claisen condensation, Knoevenagel reaction, Stobbe reaction, Reformatsky reaction, Mannich reaction, Darzen’s glycidic ester synthesis, Perkin reaction, benzoin condensation, Dieckman reaction, acyloin condensation, nucleophilic addition (Michael addition) to α,βunsaturated carbonyl system 4. Molecular rearrangement (5 lectures) Wagner-Meerwein, Pinacol-Pinacolone, Dakin, Bayer-Villiger, Beckmann, Favorasky, Hoffmann, Lossen, Schmidt, Curtius, benzil-benzillic acid, dienone-phenol, Wolf, Claisen, Fries, Photo Fries, Orton, Demjanov, benzidinesemidine 5. Reagents in organic synthesis (6 lectures) Grignard, alkyl lithium, LDA, LiAlH4, B2H6, Me3SiCl, R2CuLi, Wilkinson catalyst, NaBH4, DIBAL-H, 1,3-dithiane, OsO4, KMnO4 6. Named reactions (6 lectures) Birch, von Richter, Houben-Hoesch, Arndt-Eistert homologation, Hell-Volhard-Zelinsky, Hunsdiecker, Oppenauer, Sandmeyer, Stephen, Williamson ether synthesis 7. Alicyclic compounds (6 lectures) Structure of simple alicyclic compounds upto sixmembered ring; strain theory in classical and modern theoretical approach, ease of ring formation; physical properties with respect to dipole moment and acid strengths (cyclohexane system only) Synthesis and reactions in cyclohexane systems: E2 elimination, rearrangement, SN1 and SN2 including NGP, oxidation of cyclohexanols 8. Synthesis, physical properties and reactions (6 lectures) (i) Aliphatic and aromatic nitrogen compounds: amines, nitro compounds, nitroalkanes, alkyl nitriles, aromatic diazonium compounds, diazomethane; (ii) nitrophenols, aminophenols, nitroanilines, amino carboxylic acids9 9. Aromatic electrophilic substitution (8 lectures) Mechanism, orientation and reactivity; nitration, nitrosation, sulfonation, halogenation, Friedel-Crafts, Haworth synthesis, Gatterman-Koch, Gatterman, Hoesch, Vilsmeier-Haack, Reimer-Tiemann, Kolbe-Schmidt, chloromethylation, Manasse, Kolbe 10. Aromatic nucleophilic substitution (5 lectures) Addition-elimination mechanism, ArSN1 mechanism, elimination-addition (benzyne) mechanism; orientation and reactivity. BSc Part-III Chemistry (Hons.) Paper X Full Marks: 100 ORGANIC CHEMISTRY (THEORY) Group A 1. Dyes (3 lectures) Phenolphthalein, methyl orange, malachite green, alizarin 2. Medicinal chemistry (5 lectures) Preliminary concept on pharmacodynamics and pharmacokinetics; syntheses and uses of paracetamol (antipyretic), aspirin and phenacetin (analgesics), sulphanilamide and sulphaguanidine (sulpha-drugs), chloroquine (antimalarial) 3. Heterocyclic compounds (16 lectures) Syntheses, properties and uses of furan, pyrrole, thiophene, pyridine, quinoline, isoquinoline and indole 4. Amino acids and proteins (14 lectures) Essential and non-essential amino acids, isoelectric point, ninhydrin reaction, synthesis of glycine, alanine and tryptophan; classification of proteins, geometry of peptide linkage, elementary idea about primary and secondary structures of proteins; C-terminal, N-terminal and their determination; peptide synthesis, Merrifield synthesis 5. Carbohydrate chemistry (11 lectures) Chemistry of monosaccharides and disaccharides including structures and configurations: D-glucose, fructose, galactose, arabinose and sucrose; stepping-up and stepping-down of monosaccharides, conversion of aldose to ketose and vice versa; mutarotation, epimerization, anomeric effect, elementary idea about starch and cellulose 6. Alkaloids and terpenenoids (11 lectures) General studies of terpenenoids and alkaloids; biosynthesis of terpenes; determination of structures of citral, nerol, α-terpineol, piperin, ephedrine and coniine Group B 7. Methodology in organic synthesis (15 lectures) Disconnection approach, synthon, synthetic equivalents, umpolung, one-group disconnection of alcohols, olefins and ketones; synthesis involving enolates and enamines with special reference to diethyl malonate and ethyl acetoacetate; two-group disconnections for dioxygenated molecules (1,2-; 1,3-; 1,4-; 1,5- and 1,6-systems), Robinson annelation; reconnection; synthesis through protection of functional groups 8. Pericyclic reactions (16 lectures) FMO approach, definition, classification, electrocyclic reactions (including Woodward-Hofmann selection rules): [4+2] cycloaddition with special reference to Diels-Alder reaction, alder ene reaction, [2+2] cycloaddition; sigmatropic reactions: [1,j] and [i,j] shifts, [1,3] and [1,5] H-shifts, [3,3] sigmatropic shifts with reference to Cope and Claisen rearrangements 9. Spectroscopy (20 lectures) UV: Electronic transitions with reference to σ-σ*, n-σ*, π-π*, n-π* transitions; absorption maximum and absorption intensity, effect of solvent; Woodward rule with reference to conjugated system like dienes, trienes and α,β-unsaturated carbonyls including cyclic systems IR: Hooke’s law, stretching and bending vibrations, characteristic and diagnostic stretching frequencies, factors affecting stretching frequencies (H-bonding, electronic factor, ring size), finger-print region, diagnostic bending frequencies for benzene and its o-, m- and p-isomers 1H NMR: Principle, nuclear spin, NMR-active nuclei, chemically equivalent and nonequivalent protons; chemical shift, upfield and downfield shifts; shielding/deshielding of protons in systems involving C-C, C=O, C=C, benzene, cyclohexane; spin-spin splitting with reference to CH3CH2Br, CH3CH2OH, Br2CHCH2Br; characteristic 1H NMR signals for simple molecules Application of the above spectroscopic methods in structure elucidation of simple organic molecules 10. Nucleic acids (4 lectures) Heterocyclic bases, nucleosides, modified nucleosides, nucleotides; idea about DNA and RNA 11. Green chemistry (5 lectures) Principles, starting materials, reagents, solvents, catalysts, utilities. UG GENERAL COURSE / PASS COURSE BSc Part-I Chemistry (Gen.) Paper I Full Marks: 100 ORGANIC CHEMISTRY (THEORY) Group B Organic Chemistry (Full Marks: 50) 1. Functional Nature of Organic Compounds Classification of organic compounds in terms functional groups, their IUPAC nomenclature and valence bond structures. 2. Electron Displacement in Molecules Concept of Inductive effect, Electromeric effect, Hyperconjugation, Resonance, Aromaticity and Tautomerism. 3. Introduction to Organic Reaction Mechanism Homolytic and heterolytic bond cleavage; Reaction intermediates: carbocation, carbanion, free radical. Classification of organic reactions (substitution, elimination, addition and rearrangement) and reagent types (electrophiles, nucleophiles, acids and bases), Ideas of organic reaction mechanism (SN1, SN2, E1 and E2). 4. Chemistry of Hydrocarbons a) Free radical substitutions of alkanes; b) Formation of alkenes, electrophilic addition reactions of alkenes (upto four carbon atoms), Markwonikoff’s rule, peroxide effect, ozonolysis, radical addition and catalytic reductions; c) Formation of alkynes, their partial and complete reductions and hydration. Halogen derivatives of alkanes, their nucleophilic substitutions and elimination reactions. 5. Mono and Bifunctional Compounds Preparations and properties of primary, secondary and tertiary monohydric alcohols, ethers, ethylene glycol, pinacol and glycerol; aldehydes and ketones; monocarboxylic acids and their derivatives: acid chlorides, anhydrides, esters, amides; amines; unsaturated alcohol (allyl alcohol), unsaturated aldehyde (acrolein), unsaturated carboxylic acid (acrylic acid), unsaturated ester (methyl acrylate), di- and tribasic acids (oxalic, malonic, succinic acids; malic and citric acids). 6. Stereochemistry Concept of optical activity, optical properties of lactic acid and tartaric acid, D,L and R,S nomenclature; Geometrical isomerism with reference to fumaric acid and maleic acid; cis-trans and E, Z nomenclature. 7. Chemistry of Aromatic Compounds Modern concept of structure of benzene, general mechanism of aromatic electrophilic substitution reactions, preparations and properties of toluene, xylene, halobenzenes, benzyl chloride, benzoyl chloride, benzotrichloride, nitrobenzene, dinitrobenzene, TNT, aniline, methyl and dimethyl aniline, benzyl amine benzene diazonium chloride, phenols, benzyl alcohol, benzaldehyde, acetophenone, benzoic acid, anhydride, amides, esters; phenyl acetic acid, salicylic acid, cinnamic acid, sulphanilic acid, phenyl hydrazine, nitrophenols and picric acid. 8. Organic Synthesis Preparation and synthetic uses of diethyl malonate and ethylacetoacetate. Application of Grignard reagents in synthesis of ketones, secondary and tertiary alcohols and carboxylic acids. 9. Carbohydrates Open-chain and ring structures glucose, fructose and their mutarotation, idea of dissacharides with reference to cane sugar. BSc Part-III Chemistry (Gen.) Paper IV Full Marks: 65 ORGANIC CHEMISTRY (THEORY) 1. Chemistry of Selected Biomolecules Structural aspects (excluding elucidation and stereochemistry, unless specified) and important function of d/l-sucrose and polysaccarides (starch and cellulose), amino acids (classification, essential amino acids like glycine, alanine, methionine and tryptophan with d/l), proteins (special reference to the peptide bond, action of haemoglobin, idea of denaturation of proteins, classification and functions of enzymes in general), pyrrole, pyridine, pyrimidine and purine, nucleic acids (DNA and RNA), nucleotide and nucleoside. 2. Medicinal Chemistry Antipyretics and analgesics like paracetamol and aspirin, sulphadrugs like sulphadiazine, antibiotics like penicillin and chloramphenicol,ofloxacin; antiamoebic like metronidazole, anticancer drugs, drugs used for AIDS (detailed structures are not needed, only the nature and function of the drugs). ********************