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POSTDOCTORAL POSITIONS ARE AVAILABLE IMMEDIATELY IN THE LABORATORY OF MOLECULAR CONTROL OF MORPHOGENESIS AND TUMOR PROGRESSION Professor Jean Paul Thiery, Principal Investigator, Institute of Molecular Cell biology (IMCB), A*STAR, Singapore. Applicants should have a Ph.D. degree and have at least one first author peer-reviewed paper in a well recognized international journal. A strong background in biophysics or in cell molecular developmental biology is required. Several projects are ongoing in the laboratory on the mechanochemistry of cell adhesion and on mechanisms driving epithelial-mesenchymal transition. The laboratory explores mechanisms regulating cell migration in vivo using new transgenic models targeting the neural crest. Induction and branching morphogenesis is analyzed in the mammary gland in vitro and in vivo with recently developed transgenic models. The laboratory is also engaged in a large screen of oncogenes and tumor suppressor genes involved in cancer progression, taking advantage of a new extremely powerful method of insertional mutagenesis based on transposition. There is a particular focus on breast carcinoma basal cell subtypes. IMCB is the largest of the A*STAR Institutes in Singapore, located on the new campus of Biopolis. More than 5000 scientists are now working on this multidisciplinary campus, close to the National University of Singapore. Core facilities include very large computing facilities, bioinformatics and most advanced oncogenomic, bioengineering and nanotechnology platforms. X-ray crystallography, large scale production of cells and proteins, DNA sequencing, NMR, mass spectrometry, flow cytometry, video, TIRF, FRAP, FRET and confocal microscopy are all available at IMCB. IMCB houses one of the most advanced zebrafish facilities in the world, and has direct access to one of largest animal facilities. Biomedical science has become a top priority of the Republic of Singapore, which is now already widely considered to be the new eldorado for scientists. Research is fully supported by government funding making everyday laboratory life much easier than in many other countries. Singapore is a small city state of 4.5 million, on an island at the southern tip of Malaysia. It is a multicultural and multiracial society. Changi Airport is considered to be the best airport worldwide in term of effectiveness and connections. The cost of living is relatively low (compared to countries in Europe and North America); income tax is one of the lowest in the world. Many international schools and universities now operate in Singapore. Long term employment prospects are good. A scientific career in Singapore, following a postdoctoral position, can be easily envisioned due to the very rapid expansion of academic institutions. The private sector is flourishing in Singapore and offers multiple opportunities for senior positions. Interested individuals should send their application, CV and name and address of three referees to: Professor Jean Paul Thiery Institute of Molecular and Cell Biology Proteos, 61 Biopolis Drive, 138673 SINGAPORE Tel 6565869621 Mail: [email protected] Web: http://www.imcb.a-star.edu.sg