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U.S. Postage PAID Permit No. 4860 symposia & events 2016 February 20-26, 2016 9th Annual Illinois Eye Review Friday, April 22, 2016 9th Annual Retina Symposium Wednesday, May 25, 2016 2016 Spring Glaucoma Symposium Friday, June 17, 2016 40th Annual Alumni / Resident Day Sunday, October 16, 2016 Alumni Reception at the AAO Meeting Saturday, October 22, 2016 The Chicago Chronic GVHD Meeting http://eyecare.uic.edu l www.chicago.medicine.uic.edu/eye Proud Community Partner ONE VISION2014-15 Department of Ophthalmology and Visual Sciences Illinois Eye and Ear Infirmary University of Illinois College of Medicine AND EAR INFIRMARY IN THIS ISSUE 1 2 4 6 8 10 28 32 34 36 38 40 48 49 Leadership Shedding Light on the “Bionic Eye” Artificial Cornea Program Flourishes PROSE Clinic Makes Strides Stem Cells and Sight Clinical Services/Faculty Research Faculty Sponsored Research Clinical Investigations and Trials Giving Education Publications In Memoriam; Investiture Cless Lab LEADERSHIP Mark I. Rosenblatt, MD, PhD, MBA | Professor and Department Head Lions of Illinois/Charles I. Young Chair in Ocular Research Joel Sugar, MD | Vice Chair for Clinical Operations Joel Sugar MD Professor in Ophthalmology William F. Mieler, MD, FARVO | Vice Chair for Education Cless Family Professor in Ophthalmology Mahnaz Shahidi, PhD | Vice Chair for Research Morton F. Goldberg MD FACS Professor in Ophthalmology CLESS FAMILY OPHTHALMIC SURGICAL TRAINING AND SIMULATION CENTER Timothy McMahon, OD, FAAO | Vice Chair for Optometry Professor of Ophthalmology R. V. Paul Chan, MD, FACS | Vice Chair for Global Ophthalmology Professor of Ophthalmology The Illinois Eye and Ear Infirmary is known as a leader in the field of ophthalmic training in the region and in the nation. One component of this leadership is providing the highest level of surgical training that is available. This year we inaugurated the 9 station state-of-the-art Cless Family Ophthalmic Surgical Training and Simulation Center (Cless Lab), the premier center for ophthalmic surgical training in the Midwest. The Cless Lab will be home to surgical training courses, webcasting and live surgery streaming as well as surgical simulation technology. A generous investment made by the Cless Family Foundation, along with support from faculty and alumni, made this vision a reality. Establishing the Cless Lab is an enormous advancement in how we train our residents and surgical fellows. It is an active learning environment allowing for a virtual-reality simulation experience within which attention to the finest, most minute details, such as the careful orchestration of hand and foot instrument manipulation, can be perfected without putting patients at risk. It will no doubt significantly increase trainees’ aptitude and confidence when performing in a live operating room. The virtual connections this equipment makes possible will enable us to examine how fellow surgeons from all corners of the world do work, and repeat it right here. This exposure to new information and practices will fuel the innovation and breakthroughs that will happen here first. And, when they do, we can share them with the rest of the world right from the Cless Lab. We now are able to provide services few places in the world can offer. Our faculty, residents, fellows, alumni and local ophthalmologists can learn more, innovate faster and pioneer surgical curriculum because of these connections. CREDITS Writers Lisa Holton Margaret Doyle Editor Laurie Walker Designer Lisa Birmingham Contributors Margaret Chervinko, Lauren Hughes, Cristina Lee, Kristen Scheurich, Laurie Walker Photography Cathy Carroll, Joshua Clark, Roberta Dupuis-Devlin, Mark Janowicz On the cover Visionary by Gwyn Newcombe Left to right: Drs. Sugar, McMahon, Shahidi, Mieler and Rosenblatt—not pictured, Dr. Chan A MESSAGE FROM THE DEPARTMENT HEAD I am deeply honored to serve as the Head of the Department of Ophthalmology and Visual Sciences at the Illinois Eye and Ear Infirmary/University of Illinois College of Medicine. The Department has a historic legacy of unparalleled clinical care, outstanding education, and innovative research. This could not have been done without the combined efforts of our faculty, staff and supporters. For over 155 years, the Infirmary has been leading the way in advanced care for patients who have some of the most serious and complicated eye conditions. The subspecialty services and clinicians in the Department are nationally known for providing this care. We all share in this invaluable commitment to treating and curing eye diseases such as cataracts, glaucoma, and age-related macular degeneration. Ophthalmologic innovation is happening here. The modern healthcare landscape and the rapid development of new technologies present us with a unique opportunity to foster innovation and pursue new connections between medicine and engineering to address complex ophthalmic conditions. We are pursuing the development of new fellowship opportunities, including ones in global ophthalmology, which will allow us to inspire innovation here at home and impact patients and clinical care around the globe. Our scientific discoveries will influence how we treat the most serious and complicated eye conditions, and enhance the quality of life for our patients. Our Illinois Eye and Ear Infirmary (IEEI) residents and trainees have shaped our department, programs and clinics. Their commitment to innovative, inspired and impassioned medicine has helped to establish IEEI as a national center for excellence in resident education. We are proud to train the best and brightest in ophthalmology and we are excited to roll out a brand new surgical curriculum for our trainees in 2016 that corresponds with our new state-of-the-art Cless Family Ophthalmic Surgical Training and Simulation Center. Innovative medicine is happening now. In the Department of Ophthalmology and Visual Sciences, we are pioneering innovation in three important areas: high-resolution functional imaging, nanoscale device development and tissue engineering to help us better diagnose and treat eye disease earlier, and preserve the sight of our patients. Mark I. Rosenblatt, MD, PhD, MBA Professor and Head Department of Ophthalmology & Visual Sciences Lions of Illinois /Charles I. Young Chair in Ocular Research Director, Corneal Regenerative Medicine Laboratory Medical School University of Miami (PhD, Biochemistry) Residency in Ophthalmology Massachusetts Eye and Ear Infirmary Clinical Fellowship Massachusetts Eye and Ear Infirmary (Cornea) Research Fellowship Schepens Eye Research Institute Graduate School New York University (MBA) In order to continue to lead and stay in sync with advances in medicine, science and technology, we have established an exciting partnership with the University of Illinois College of Engineering at Urbana-Champaign. This partnership will support joint conferences, train physicians and scientists, and collaborate between departments to develop solutions for sight-threatening diseases. Our intentional convergence of medicine and engineering will greatly improve ophthalmic conditions around the world. Our new Ophthalmology Clinical Trials Center underscores our commitment to medical research, which has contributed to advances in Ophthalmology and related areas of medicine. These fundamental discoveries impact our academic medical program and allow us to provide quality eye care to those in need. We offer our gratitude to our friends and supporters and invite you all to join us on this journey for ongoing innovation, productivity and discovery. OneVision | 1 SHEDDING LIGHT ON THE “BIONIC EYE” The University of Illinois’ Argus II trial moves ahead, returning sight to the blind. The Argus II® retinal prosthesis system – also known as the “Bionic Eye” trial – has been making news at the Illinois Eye and Ear Infirmary’s (IEEI) Department of Ophthalmology since manufacturer Second Sight named the IEEI one of 13 North American clinical testing sites after getting FDA approval in 2013. planted with an electronic device and that the vision will not be ‘normal vision,’” she explained. At this time, the device does not allow for enough resolution to see faces or colors. However, for many patients, the added visual information provided by Argus II can improve the patient’s ability to navigate paths, find doorways and “see people moving about,” returning a significant degree of visual independence to their lives. Additionally, given advances in engineering which allows technology to become smaller and more powerful over time, vision outcomes, comfort and other features of the bionic eye project will improve. “It’s the chance to give some sight back to patients blind from retinitis pigmentosa. Right now, there is no other way you can return vision to completely blind patients,” explains project leader Jennifer I. Lim, MD. The Argus II system is designed to restore limited sight to individuals suffering from retinitis pigmentosa, a genetic disease that causes “Today, depending on how severely impaired a patient’s progressive blindness by destroying the light-sensing cells vision is, a patient might be able to see a white line that in the retina. Eventually, this artificial can help them walk independently retina system may help tackle other or be able to sort clothing into light sight-destroying diseases like macuand dark colors,” Lim explains. Fular degeneration. ture upgrades to the Argus system “A lot of the most common – named for the all-seeing giant The University of Illinois Hospital & procedures you see today of Greek mythology – might not Health Sciences System is the only only eliminate the current required were in clinical trials at the medical center in Illinois selected to bulky headgear of dark glassoffer the artificial retina. Lim says IEEI including the first clinical es and head-mounted camera the success of the device – a surbut also provide the possibility of trials for diabetic retinopathy, gically implanted chip on the retina sharper images. that wirelessly receives informamacular degeneration, vein tion from a head-mounted camera Lim has worked with the inventor occlusion and sickle cell to help blind individuals “see” light of the device, Mark S. Humayun, and shapes in black and white – deMD, PhD, the biomedical engineer management. pends on the patient’s motivation and retina physician who develand willingness to undergo “visual oped the bionic eye at the Univertraining after implantation” to learn sity of Southern California. She how to use the device. points out that such collaborative relationships are common at the Department of Ophthalmology. The device uses an electrode array that goes directly onto the patient’s retina. The electronic chip is connected to a “The Department has always been a place of innovation,” silicone strip that holds a receiver and is mounted to the said Lim. “A lot of the most common procedures you see outside of the eye. There is no discomfort and the current today were in clinical trials at the IEEI including the first technology is still in the early phase, Lim adds. “It’s not clinical trials for diabetic retinopathy, macular degeneraright for everyone” suffering from RP, Lim explains. “A pation, vein occlusion and sickle cell management. We are tient has to be comfortable knowing that they will be imjust in the early stages with this implant,” she said. 2 Argus® II illustration courtesy of Second Sight Medical Products, Inc. “It’s the chance to give some sight back to patients blind from retinitis pigmentosa. Right now, there is no other way you can return vision to completely blind patients,” explains project leader Jennifer I. Lim, MD. OneVision | 3 ARTIFICIAL CORNEA PROGRAM FLOURISHES It takes a particular kind of patient to assure success, but the Department of Ophthalmology’s work with the toughest cases has made it the Midwestern leader in artificial cornea transplantation. For over 150 years, the Department of Ophthalmology and Visual Sciences at the Illinois Eye and Ear Infirmary (IEEI) has provided the field of ophthalmology with a long list of firsts in research, surgical technique and groundbreaking patient care. ease and we have formed a team of specialists to provide them with the most comprehensive care possible. At the IEEI we have incorporated cornea, glaucoma, vitreoretinal, oculoplastics, contact lens and uveitis specialists into the artificial cornea team resulting in an interdisciplinary approach” said Cortina, Director of the Artificial Cornea Program at the University of Illinois College of Medicine. Henry Winters knows this personally. Winters’ life changed on Jan. 5, 1978 when he suffered chemical burns over 60 percent of his body at the manufacturing plant where The Department has he worked as a supervisor. “I got hurt at 27 years of age, and I was in suspended animation from that day,” said Winters, who was comAs the work of the Artificial pletely blind for three years before receiving his first of several transCornea Program continues, planted natural corneas starting in patients like Winters illustrate the 1980s. one of the largest artificial cornea programs in the country with a strong research team to complement the large clinical program. Our goal is to advance the field of artificial cornea and we have made significant contributions including improvement of surgical outcomes using high resolution imaging to evaluate the formation of damagthe Department’s unique Unable to work or drive from the ing membranes behind the Kpro approach to the toughest day of the accident, Winters got device and studying the formation minimal and temporary improveof potentially dangerous microbial cases in eye medicine. ment from those transplants and in biofilms on the device. Additionally, recent years, he noticed again that our engineering and basic science the remaining vision in his left eye team lead by Drs. Yu and Rosenblatt is investigating new began to worsen. He and his wife started to look for other materials and designs for a novel Keratoprosthesis device. options, and in 2012, Winters and his doctor M. Soledad Cortina started discussing the transplantation of the arCortina and fellow faculty member Jose de la Cruz have tificial cornea known as the Boston Keratoprostheses, or published a seminal first textbook on KPro technology and KPro. KPro is now considered a surgical option for patients transplant. The team gathered the latest and most comprewith poor prognosis for standard corneal transplants or hensive knowledge and best practices on the device from whose corneal transplants have failed. Later in 2012, Winleading specialists around the world and published “Kerters was implanted with a Boston Type 1 KPro. After more atoprostheses and Artificial Corneas: Fundamentals and than 30 years, he finally saw clearly from his less-injured Surgical Applications” late in 2014. Says Cortina: “Much of left eye. what you will find in the book goes beyond current literature to experiences that have not been shared anywhere “It was so exciting – it was the first time out of all those else. All aspects of KPro surgery, from history and preopyears that I got a chance to see me,” Winters explained. “I erative evaluation to surgical techniques and postoperacould go places, see places and I could read. When you tive management of complications, are addressed by more start seeing the words again after you’ve heard them all than two dozen leading surgeons as chapter authors in the that time, they don’t feel the same. I was finally able to get first edition. familiar again with what I saw.” As the work of the Artificial Cornea Program continues, Now 65, Winters is retired and has elected not to try to patients like Winters illustrate the Department’s unique drive. But seeing again reminded him how withdrawn he approach to the toughest cases in eye medicine. “Our was for so much of his life. patients come to us with a variety of visual and physical challenges that few treatment centers see,” said Cortina. “The Department of Ophthalmology at the IEEI has a par“We believe that our interdisciplinary approach allows us to ticular and unique approach to the artificial cornea. We untransform the lives of some of our sickest patients.” derstand that these patients suffer from complex eye dis- 4 “It was so exciting – it was the first time out of all those years that I got a chance to see me,” Winters explained. “I could go places, see places and I could read...I was finally able to get familiar again with what I saw.” Front Part Corneal Graft Back Plate Front Part Corneal Graft Back Plate OneVision | 5 PROSE CLINIC MAKES STRIDES New prosthetic solutions help patients regain sight, mobility and independence PROSE (short for Prosthetic Replacement of the Ocular Surface Ecosystem) is a device and treatment system that aims to restore vision, promote healing and improve the quality of life for patients with complex corneal disease. 6 When Dr. Ellen Shorter, OD, FAAO joined the Department of Ophthalmology and Visual Sciences at the Illinois Eye and Ear Infirmary (IEEI), one of her first objectives was to complete the intensive BostonSight® PROSE Clinical Fellowship. Rapaport conferred with her doctors at Milwaukee’s Eye Institute and mentioned she had heard about PROSE. They referred her to the Department’s PROSE Clinic and after her first visit to Chicago in January 2014 she planned to began treatment that summer. Pioneered at the Boston Foundation for Sight, PROSE (short for Prosthetic Replacement of the Ocular Surface Ecosystem) is a device and treatment system that aims to restore vision, promote healing and improve the quality of life for patients with complex corneal disease. PROSE prosthetics are thin transparent devices made of gas-permeable plastic that allow oxygen and a healing saline solution to reach the ocular surface. The device fits under the eyelid and rests on the sclera (the white tissue of the eye), vaulting the cornea, and creating a reservoir of saline solution that continuously bathes the diseased eye in oxygenated artificial tears. The result is a new, smooth optical surface. In 2010 the IEEI opened its PROSE Clinic, one of only 12 in the United States, with Shorter as its first director. “Most of our patients have severe ocular surface disease or advanced corneal ectasia,” Shorter explains. “Many of our patients have been to multiple eye doctors and are frustrated. PROSE treatment is a final option when other standard therapies have failed.” Even better, Rapaport said she can now clearly see her newborn grandchild. “It’s just been phenomenal.” For many patients, PROSE may be the ideal and sometimes only treatment that can restore vision and dramatically reduce eye pain and light sensitivity. PROSE offers hope to patients with conditions such as Stevens-Johnson syndrome (SJS), severe dry eye syndrome, Sjogren’s syndrome, keratoconus, pellucid marginal degeneration (PMD), ocular trauma and post-transplant or LASIK complications. For example, Shorter notes that several of her patients have had cancer and may suffer from chronic graft versus host disease (cGvHD), which can occur six to 12 months after a bone marrow transplant. “Patients with ocular cGvHD have severe dry eye with constant, debilitating eye pain and light sensitivity,” she explains. PROSE patient Sheri Rapaport had no experience with cancer but had developed keratoconus, a degenerative corneal disease, in her 20s. She learned about PROSE from a friend’s son who had leukemia and developed cGvHD. He was a medical student, and had done some research on the PROSE devices. “I could see with the PROSE devices immediately,” says Rapaport. All PROSE devices are customized with computer-aided design (CAD) software to precisely fit the patient’s unique eye shape and are manufactured in the Boston Foundation’s state-of-the-art lab. It can take several months of customization to get the best fit. Dr. Shorter and her team help to train patients on the devices which are removed at bedtime and re-inserted in the morning. PROSE devices can solve a variety of eye problems. Patients like Sheri Rapaport cannot see with spectacles and her PROSE devices aid her vision. Other patients might need them to permanently protect or temporarily heal the ocular surface due to injury. Rapaport says Dr. Shorter has been a calming influence throughout her treatment. “It has been a real hopeful, positive process from the beginning.” She adds, “Now I can go to the grocery store and see what is on the shelves…it’s like PROSE has given me my independence back.” Even better, Rapaport said she can now clearly see her newborn grandchild. “It’s just been phenomenal.” Rapaport, 67, had undergone four cornea transplants over the previous four decades with only minimal success. “Every procedure worked for a short time,” she explained, “then the keratoconus took over again.” Eventually, Rapaport couldn’t drive anymore or perform everyday tasks due to her severely diminished eyesight. “Even going to the grocery store was a challenge,” she recalls. OneVision | 7 STEM CELLS AND SIGHT Can stem cell technology at the squeeze of an eyedropper promote healing and regeneration for the worst injuries and diseases of the eye surface? Severe and chronic ocular injuries and diseases have long vexed ophthalmologists trying to find ways to accelerate healing and promote regeneration of the eye surface. Stem cell research might finally provide an answer. this research to the clinic. We see the most difficult patients that no one else is able to take care of.” He adds that “the Department of Ophthalmology has a long history of cultivating important research with the infrastructure to do top quality work.” “We’ve never had very effective treatments for severe eye injuries and for chronic conditions where the corneal This particular project has been supported by the surface cannot regenerate itself,” says Ali Djalilian, MD, U.S. Department of Defense, which is seeking greater Associate Professor of Ophthalmology/Cornea Service. treatment options for eye injuries and combat-related That’s why Djalilian, Director of the Infirmary’s Corneal conditions. Djalilian’s project is also being supported with a Epithelial Biology and Tissue Engigrant from the Vision for Tomorrow neering Laboratory, is researching Foundation, a Chicago-based ways to apply stem cell-produced organization that supports families factors – specialized proteins that affected by aniridia—an absence “If this works, (Djalilian) can get diseased or injured cells to of the iris in one or both eyes, or will literally be changing heal – as a topical treatment on the albinism—a disorder that prevents eye surface. the body’s ability to produce or the course of treatment for distribute melanin. Djalilian anticipates that such stem thousands of people. cell-produced factors may be disHelen Mopsick, board member at pensed through eyedrops or by Vision for Tomorrow, said the orspecialized contact lenses that lock ganization connected with Djalilian the healing solution in place. in 2011 and supports the research because current treatment for aniridia is a cornea trans“We think this will be helpful for a wide range of patients plant. Said Mopsick, “If this works, (Djalilian) will literally be with severe injuries or diseases of the surface of the eye,” changing the course of treatment for thousands of people. says Djalilian of the 1 million dollar project, which launched Part of the condition of aniridia is that if the cornea starts to about a year ago and is roughly two to three years away deteriorate in someone’s late teens or early twenties, the from human trials. injury just doesn’t heal.” Stem cells are cultured in the Infirmary laboratory so such factors can be collected,” says Djalilian. To date, most of his studies have “been based on optimizing those conditions and testing them in animal models.” This summer, the Department’s team is hoping to begin pre-clinical studies that will eventually allow the U.S. Food and Drug Administration to give the Department clearance to start clinical trials. Stem cell research is a very hot topic right now in ophthalmology, but Djalilian says the Department provides a unique home for this new technology to flourish. “As a department and a team, we are set up very well to translate 8 Mopsick added that Djalilian approached the foundation and a lab visit made it a partnership. “He has quite a few patients and we love finding researchers who are also in clinic,” she said. “This is our first project with [the Department of Ophthalmology at the Illinois Eye and Ear Infirmary], and it’s been a very good experience: very responsive. And we’ll be back.” “As a department and a team, we are set up very well to translate this research to the clinic. We see the most difficult patients that no one else is able to take care of.” OneVision | 9 CORNEA AND REFRACTIVE SURGERY The Cornea and External Disease Service manages patients with diseases of the front of the eye including corneal and conjunctival infections, keratoconus, cataracts, tumors of the iris and conjunctiva, blepharitis, dry eye, corneal scarring, complications of trauma and ocular surgery as well as hereditary corneal diseases like Fuchs’ Dystrophy. The service has extensive expertise in all forms of partial thickness corneal transplantation including DMEK, DSAEK/ DSEK, and DALK as well as traditional penetrating keratoplasty that provides patients with the widest array of treatment options. Those not eligible for human corneal transplantation may qualify for our Artificial Cornea Program, which is the largest program of its kind in the Midwest for implanting keratoprostheses. The service also provides access to state-of-the-art imaging technology to quickly and accurately diagnose a wide spectrum of diseases. Cornea specialists also work with the Contact Lens Service to offer advanced contact lens therapies including the PROSE lens and offer the opportunity to participate in the latest clinical trials for dry eye diseases, corneal transplantation and corneal infections. IMAGE: Photo of iris and pupil courtesy of the Eye Photography Service. 10 DIRECTOR Elmer Y. Tu, MD Professor of Clinical Ophthalmology Director, Cornea Service MEDICAL SCHOOL University of Miami RESIDENCY IN OPHTHALMOLOGY University of Wisconsin CLINICAL FELLOWSHIP Bascom Palmer Eye Institute (Cornea) Clinical Interests Corneal transplantation including DMEK, DSAEK, DALK and Full thickness corneal transplantation; Corneal infections and corneal inflammatory disorders; Complex and routine cataract surgery Research Interests Corneal infections and inflammation; Corneal transplantation; New surgical and drug therapies Dimitri T. Azar, MD, MBA Dean, University of Illinois College of Medicine Distinguished Professor of Ophthalmology, Bioengineering and Pharmacology B.A. Field Chair in Ophthalmologic Research MEDICAL SCHOOL American University of Beirut, Lebanon RESIDENCY IN OPHTHALMOLOGY Massachusetts Eye and Ear Infirmary CLINICAL FELLOWSHIP Massachusetts Eye and Ear Infirmary (Cornea) RESEARCH FELLOWSHIP Schepens Eye Research Institute GRADUATE SCHOOL University of Chicago (MBA) Clinical Interests laser vision correction; cornea and cataract surgery M. Soledad Cortina, MD Assistant Professor of Ophthalmology Director, Comprehensive Ophthalmology Faculty Practice (COFP) and General Eye Clinic Director, Artificial Cornea Program MEDICAL SCHOOL University of Buenos Aires School of Medicine, Argentina Jose de la Cruz, MD Assistant Professor of Ophthalmology Co-Director, Millennium Park Eye Center MEDICAL SCHOOL Ponce School of Medicine, Puerto Rico RESIDENCY IN OPHTHALMOLOGY New York Eye and Ear Infirmary RESIDENCY IN OPHTHALMOLOGY Louisiana State University CLINICAL FELLOWSHIP Massachusetts Eye and Ear Infirmary (Cornea) CLINICAL FELLOWSHIP Illinois Eye and Ear Infirmary (Cornea) GRADUATE SCHOOL Indiana University at Bloomington (MS) RESEARCH FELLOWSHIP Louisiana State University, Neuroscience Center Clinical Interests Advances in keratoprosthesis transplantation; Anterior segment imaging in cornea and refractive surgery; Femtosecond technology for corneal tranplantation Clinical Interests Ocular surface disease and high-risk corneal transplantation including Boston keratoprosthesis; Cataract surgery and endothelial keratoplasty Research Interests Sterile keratolysis in Boston keratprosthesis patients; Optical properties of artificial corneas; Corneal nerves and their regeneration after injury Research Interests Development of surgical devices for conjunctival manipulation; New techniques in refractive surgery and femtosecond assisted keratoplasty; Advanced technology intraocular lenses for correction of presbyopia and astigmatism Ali R. Djalilian, MD Sandeep Jain, MD Mark I. Rosenblatt, MD, PhD, MBA MEDICAL SCHOOL University of Minnesota MEDICAL SCHOOL University of Delhi, India RESIDENCY IN OPHTHALMOLOGY University of Minnesota RESIDENCY IN OPHTHALMOLOGY Harkness Eye Institute CLINICAL FELLOWSHIP Cincinnati Eye Institute (Cornea) CLINICAL FELLOWSHIP Massachusetts Eye and Ear Infirmary (Cornea) RESEARCH FELLOWSHIP University of Minnesota (Cornea) RESEARCH FELLOWSHIP Wilmer Eye Institute (Cornea) RESEARCH FELLOWSHIP National Eye Institute (Ocular Immunology) Clinical Interests Dry Eye and Ocular surface disease; Ocular graftversus-host-disease; Neurotrophic keratitis Research Interests Matrix metalloproteinases in corneal wound healing and angiogenesis; Refractive surgery; Optics; Accommodating intraocular lenses Associate Professor of Ophthalmology Director, Corneal Epithelial Biology and Tissue Engineering Laboratory Clinical Interests Ocular surface disease; Limbal stem cell deficiency; Corneal and limbal stem cell transplantation; Immunologic diseases of the cornea Research Interests Stem cell based therapy; Corneal wound healing; Tissue engineering Associate Professor of Ophthalmology Director, Corneal Neurobiology Laboratory Director, Dry Eye Service Research Interests Professor and Head Department of Ophthalmology & Visual Sciences Illinois Lions/Charles I. Young Chair in Ocular Research Director, Corneal Regenerative Medicine Laboratory MEDICAL SCHOOL University of Miami (PhD, Biochemistry) RESIDENCY IN OPHTHALMOLOGY Massachusetts Eye and Ear Infirmary CLINICAL FELLOWSHIP Massachusetts Eye and Ear Infirmary (Cornea) Molecular and cellular aspects of corneal nerve regeneration; Molecular and cellular aspects of ocular surface disease; Translational research RESEARCH FELLOWSHIP Schepens Eye Research Institute GRADUATE SCHOOL New York University (MBA) Clinical Interests Corneal disease; Cataract; Refractive surgery; Ocular pain; Dry Eye disease; Keratoplasty Research Interests Ocular regenerative medicine; Corneal stem cells; Corneal nerve regeneration; Angiogenesis; Tissue engineering; Biomaterials; Nanomedicine CORNEA SERVICE continued on next page OneVision | 11 CORNEA AND REFRACTIVE SURGERY (CONT.) Joel Sugar, MD Joel Sugar MD Professor in Ophthalmology Vice Chair, Clinical Operations MEDICAL SCHOOL University of Michigan RESIDENCY IN OPHTHALMOLOGY Washington University, St. Louis CLINICAL FELLOWSHIP University of Florida, Gainesville (Cornea) Clinical Interests Corneal disorders; Herpes simplex; Herpes zoster; Congenital anomalies of the anterior eye Research Interests Keratoplasty outcomes; Herpes; Fuchs dystrophy 12 Charles Qian Yu, MD Assistant Professor of Ophthalmology MEDICAL SCHOOL University of California Davis RESIDENCY IN OPHTHALMOLOGY Stanford University CLINICAL FELLOWSHIP (CORNEA) Cornell University Clinical Interests Cataract; Penetrating keratoplasty; Endothelial keratoplasty; Keratoprosthesis Research Interests Corneal healing; Artificial cornea; LASIK clinical trials; Virtual reality CONTACT LENS The Contact Lens Service provides care to patients requiring medically necessary contact lenses and related services. Our doctors are nationally known for their clinical and research expertise and their ability to help patients with various complex corneal diseases including: Keratoconus, Post-corneal transplant, Dry eye syndrome, Graft-versus-host disease (GVHD), Limbal stem cell deficiency, Sjögren’s syndrome, Neurotrophic keratitis, Corneal scarring, Stevens-Johnson syndrome, Post-LASIK, and Aphakia. We have extensive experience with all types of medically necessary contact lenses including scleral, hybrid and rigid contact lenses as well as customized soft contact lenses. The service’s PROSE clinic is one of only 12 clinic sites in America to offer BostonSight® PROSE treatment for patients with severely compromised ocular function as a result of complex corneal disease. ### DIRECTOR Charlotte E. Joslin, OD, PhD, FAAO Associate Professor of Ophthalmology Department Affiliate, Epidemiology and Biostatistics Director, Contact Lens Service OPTOMETRY SCHOOL Ohio State University College of Optometry RESIDENCY IN OPTOMETRY Jesse Brown VA Medical Center and Blind Rehabilitation Center of Hines VA Hospital GRADUATE SCHOOL University of Illinois at Chicago (PhD, Epidemiology) Clinical Interests Medically necessary contact lenses for diseases such as: Keratoconus; Post-corneal transplant; Dry eye; Graft-versus-host disease (GVHD); Limbal stem cell deficiency, Sjögren’s syndrome, Neurotrophic keratitis; Corneal scarring; Stevens-Johnson syndrome; PostLASIK Timothy T. McMahon, OD, FAAO Professor of Ophthalmology Vice Chair for Optometry OPTOMETRY SCHOOL Illinois College of Optometry RESIDENCY IN OPTOMETRY Kansas City VA Medical Center Clinical Interests Medically necessary contact lenses; Corneal topography; Anterior segment diseases and injuries Research Interests Keratoconus and other corneal ectactic conditions and diseases; Dry eye; Blepharitis Ellen Shorter, OD, FAAO Assistant Professor of Ophthalmology Director, Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) Clinic OPTOMETRY SCHOOL Illinois College of Optometry RESIDENCY IN OPTOMETRY Jesse Brown VA Medial Center and Hines VA Hospital CLINICAL FELLOWSHIP Boston Foundation for Sight (PROSE) Clinical Interests Ocular surface disease; Corneal ectasia; Keratoconus; Keratoprosthesis Research Interests Dry eye; Adenoviral conjunctivitis Research Interests Epidemiology of various eye diseases and infections; Racial differences in various eye and other health-related outcomes OneVision | 13 GLAUCOMA Glaucoma is the leading cause of irreversible blindness in the world. Our Glaucoma Service is nationally recognized as a center for the diagnosis and treatment of glaucoma in adults and children. It is a site for testing investigational new drugs and has been a leader in the use of laser and surgery to treat all forms of the disease. Our service offers comprehensive care and management of all forms of glaucoma, including specialized diagnostic testing and the latest technologies for laser and surgical treatment. Faculty members are actively involved in glaucoma research and are nationally recognized as experts in their field. DIRECTOR Thasarat S. Vajaranant, MD Associate Professor of Ophthalmology Director, Glaucoma Service MEDICAL SCHOOL Chulalongkorn University, Thailand RESIDENCY IN OPHTHALMOLOGY Illinois Eye and Ear Infirmary CLINICAL FELLOWSHIP Illinois Eye and Ear Infirmary (Glaucoma) RESEARCH FELLOWSHIP Illinois Eye and Ear Infirmary (Low Vision) Clinical Interests Diagnosis and management of glaucoma and cataract; Management of complex glaucoma and cataract; International ophthalmology Research Interests Glaucoma epidemiology; Women’s eye health; Aging of the optic nerve; Outcomes of glaucoma surgery; Management of glaucoma after corneal transplants IMAGE: Fundus photo highlighting optic nerve of glaucoma patient courtesy of the Glaucoma Service. 14 OTHER CLINICAL FACULTY David S. Hillman, MD Ahmad A. Aref, MD Assistant Professor of Ophthalmology MEDICAL SCHOOL Northwestern University RESIDENCY IN OPHTHALMOLOGY Penn State Hershey Eye Center CLINICAL FELLOWSHIP Bascom Palmer Eye Institute (Glaucoma) Clinical Interests Jacob T. Wilensky, MD Jacob T. Wilensky MD Professor of Ophthalmology Director, Glaucoma Fellowship Program MEDICAL SCHOOL Tulane University RESIDENCY IN OPHTHALMOLOGY Tulane University Affiliated Hospitals CLINICAL FELLOWSHIP Washington University, St. Louis (Glaucoma) Complex cataract surgery; Trabeculectomy and glaucoma drainage implant surgery for advanced glaucomatous disease; Microinvasive glaucoma surgery for mild/moderate glaucomatous disease; Selective laser trabeculoplasty for open-angle glaucomas; Laser iridotomy for angle-closure glaucomas RESEARCH FELLOWSHIP Research Interests Investigation of new drugs for glaucoma; Laser therapy treatment for glaucoma Surgical techniques in complex glaucomas; Risk factor analysis of steroid-response glaucoma; Glaucoma associated with retinal disorders; Novel glaucoma medical therapies; Optic nerve imaging Assistant Professor of Clinical Ophthalmology National Eye Institute (Glaucoma) Clinical Interests Diagnosis and treatment of glaucoma with special emphasis on laser therapy Mark W. Lunde, MD Assistant Professor of Clinical Ophthalmology Research Interests OneVision | 15 NEURO-OPHTHALMOLOGY The Neuro-Ophthalmology Service offers expert evaluations and treatment for neuro-ophthalmologic conditions, including: optic neuritis, idiopathic intracranial hypertension (pseudotumor cerebri), ischemic optic neuropathies, optic neuropathies of unknown etiology, ocular myasthenia gravis, cranial nerve palsies, thyroid eye disease and visual or oculomotor complications of stroke, brain tumors, multiple sclerosis and other neurological diseases. The service facilitates and interprets a wide range of diagnostic testing relevant to the diagnosis and management of neuro-ophthalmic diseases, including: Goldmann and Humphrey perimetry, infrared pupilometry, optical coherence tomography, electroretinography, lumbar punctures and magnetic resonance imaging. The service works closely with doctors in the University of Illinois Hospital and Health Sciences Systems’ departments of Neurosurgery, Neurology, Radiation Oncology and Rheumatology to provide interdisciplinary, state-of-the-art treatments. DIRECTOR Heather E. Moss, MD, PhD Assistant Professor of Ophthalmology Director, Neuro-Ophthalmology Service Director, Neuro-Ophthalmology Fellowship Program MEDICAL SCHOOL Harvard Medical School RESIDENCY IN NEUROLOGY University of Pennsylvania CLINICAL FELLOWSHIP University of Pennsylvania (Neuro-Ophthalmology) GRADUATE SCHOOL Harvard-MIT Division of Health Sciences and Technology (PhD, Medical Engineering) Clinical Interests Idiopathic intracranial hypertension; Optic neuritis; Optic neuropathies; Optic chiasm disorders; Visual disorders with neurological causes; Ocular myasthenia gravis; Cranial nerve palsies Research Interests Idiopathic intracranial hypertension; Optic neuritis; Visual system dysfunction in amyotrophic lateral sclerosis IMAGE: Brain MRI depicting orbital structures courtesy of iStock. 16 OTHER CLINICAL FACULTY Anil Gulati, MD James Goodwin, MD Peter W. MacIntosh, MD MEDICAL SCHOOL MEDICAL SCHOOL RESIDENCY IN NEUROLOGY RESIDENCY IN OPHTHALMOLOGY CLINICAL FELLOWSHIP CLINICAL FELLOWSHIP Clinical Interests CLINICAL FELLOWSHIP Associate Professor of Ophthalmology University of Illinois College of Medicine University of Minnesota Bascom Palmer Eye Institute (NeuroOphthalmology) Optic neuritis; Optic neuropathies; Ophthalmoplegia; Visual field loss; Idiopathic intracranial hypertension; Cranial nerve palsies Research Interests Optic neuritis; Autoimmune optic neuropathy; Optic nerve decompression Assistant Professor of Clinical Ophthalmology Assistant Professor of Ophthalmology The Chicago Medical School Stroger Cook County Hospital Illinois Eye and Ear Infirmary (NeuroOphthalmology) Massachusetts Eye and Ear Infirmary (Oculoplastics) Clinical Interests Idiopathic intracranial hypertension; Diplopia; Ptosis; Eyelid and orbital tumors; Orbital trauma Research Interests Thyroid eye disease; Nonarteritic anterior ischemic optic neuropathy (NAION) OneVision | 17 OCULOPLASTIC & RECONSTRUCTIVE SURGERY The Oculoplastic & Reconstructive Surgery Service provides assessment and treatment for conditions of the eyelids, orbit, face and lacrimal system. Systemic disease, trauma, birth defects and the aging process can alter the area around the eyes. Conditions such as blepharoptosis, ectropion, entropion, eyelid retraction, blepharospasm, epiphora, tumors of the ocular adnexa and orbit and fractures of the orbit are just a few of the conditions treated in this specialty. Patients can be seen at both the Illinois Eye and Ear Infirmary and the Millennium Park Eye Center. DIRECTOR Pete Setabutr, MD Associate Professor of Ophthalmology Director, Oculoplastic & Reconstructive Surgery Service Co-Director, Millennium Park Eye Center MEDICAL SCHOOL University of Texas-Houston RESIDENCY IN OPHTHALMOLOGY University of Texas-Houston CLINICAL FELLOWSHIP Illinois Eye and Ear Infirmary (Oculoplastics) Clinical Interests Cosmetic and reconstructive eyelid surgery; Orbital surgery; Diseases of the lacrimal system Research Interests Diseases of the eyelid; Diseases of the orbit; Epidemiological international vision research IMAGE: Artistic rendering of a human skull courtesy of Lisa Birmingham. 18 Vinay K. Aakalu, MD, MPH Amjad Z. Ahmad, MD MEDICAL SCHOOL MEDICAL SCHOOL RESIDENCY IN OPHTHALMOLOGY RESIDENCY IN OPHTHALMOLOGY CLINICAL FELLOWSHIP CLINICAL FELLOWSHIP Assistant Professor of Ophthalmology Director, Lacrimal Cell Biology Laboratory Mount Sinai School of Medicine Illinois Eye and Ear Infirmary Illinois Eye and Ear Infirmary (Oculoplastics) GRADUATE SCHOOL Columbia University (MPH) Clinical Interests Thyroid eye disease; Orbital tumors; Facial and ocular trauma; Ocular surface disease and scarring; Inflammatory orbital disease; Congenital eyelid and orbital disorders; Eye socket reconstruction; Facial palsies; Eyelid malposition; Lacrimal disease; Aesthetic surgery and treatments Assistant Professor of Clinical Ophthalmology University of Michigan Kellogg Eye Institute Kellogg Eye Institute (Oculoplastic & Reconstructive Surgery) CLINICAL INTERESTS Cosmetic eyelid surgery; Thyroid eye disease; Eyelid reconstruction surgery; Ptosis RESEARCH INTERESTS Cosmetic eyelid surgery Peter W. MacIntosh, MD Assistant Professor of Ophthalmology MEDICAL SCHOOL The Chicago Medical School RESIDENCY IN OPHTHALMOLOGY Stroger Cook County Hospital CLINICAL FELLOWSHIP Illinois Eye and Ear Infirmary (NeuroOphthalmology) CLINICAL FELLOWSHIP Massachusetts Eye and Ear Infirmary (Oculoplastics) Clinical Interests Lacrimal drainage surgery; Ptosis Research Interests Thyroid eye disease; Nonarteritic anterior ischemic optic neuropathy (NAION) Research Interests Regenerative medicine; Lacrimal cell biology; Dry eye disease; Cell based therapies; Orbital imaging; Orbital oncology; Novel and minimally invasive orbital and aesthetic surgery Allen M. Putterman, MD, FACS Professor of Ophthalmology MEDICAL SCHOOL University of Wisconsin RESIDENCY IN OPHTHALMOLOGY Michael Reese Hospital and Medical Center CLINICAL FELLOWSHIP Manhattan Eye, Ear and Throat Hospital (Oculoplastics) Clinical Interests Aesthetic eyelid and facial plastic surgery; Upper eyelid ptosis surgery; Thyroid eyelid and orbital problems; Eyelid and orbital tumors; Tear duct drainage surgery Research Interests Development of procedures and instruments for oculofacial plastic surgery OneVision | 19 PEDIATRIC OPHTHALMOLOGY & ADULT STRABISMUS The Pediatric Ophthalmology & Adult Strabismus Service offers general pediatric eye care, including exams for newborns and children up to 18 years of age. This service also provides other specialty clinics treating rare and unusual children’s eye disorders, including glaucoma and genetic, neurocutaneous, and neuro-ophthalmologic disorders. The doctors in this service specialize in strabismus (eye alignment disorders) in adults as well as children. Additional care providers include certified orthoptists and an oculoplastic and reconstructive surgeon. DIRECTOR Nathalie F. Azar, MD Associate Professor of Clinical Ophthalmology Director, Pediatric Ophthalmology & Adult Strabismus Service MEDICAL SCHOOL Boston University RESIDENCY IN OPHTHALMOLOGY George Washington University CLINICAL FELLOWSHIP Wilmer Eye Institute (Pediatric Ophthalmology) Clinical Interests Adult strabismus; Graves ophthalmopathy; Paralytic and restrictive strabismus; Amblyopia; Pediatric strabismus, cataracts and glaucoma Research Interests Amblyopia; Eye movement disorders; Surgical treatment techniques for strabismus; Pediatric ocular anomalies 20 Benjamin Mathew, MD Assistant Professor of Clinical Ophthalmology MEDICAL SCHOOL University of Manitoba RESIDENCY IN OPHTHALMOLOGY LSU Eye Center/ Alton Ochsner Clinic Foundation University of Ottawa Eye Institute RESEARCH FELLOWSHIP University of Ottawa Eye Institute (Ophthalmic Pathology) IIrene H. Maumenee, MD Marilyn T. Miller, MD, MS Research Professor of Ophthalmology Director, Ocular Genetics Laboratory Professor of Ophthalmology MEDICAL SCHOOL MEDICAL SCHOOL University of Illinois College of Medicine, Chicago University of Göttingen, Germany RESIDENCY IN OPHTHALMOLOGY RESEARCH FELLOWSHIPS University of Geneva (Ophthalmology and Genetics) University of Hawaii (Population Genetics) Johns Hopkins University (Medical Genetics) PRECEPTORSHIP IN OPHTHALMOLOGY Wilmer Eye Institute CLINICAL FELLOWSHIP University of Wisconsin (Pediatric Ophthalmology) Clinical Interests General pediatric ophthalmology; Pediatric cataract; Blocked tear duct; Retinopathy of prematurity Research Interests Ophthalmic optics; Automated measurement of strabismus Illinois Eye and Ear Infirmary CLINICAL FELLOWSHIP Illinois Eye and Ear Infirmary and Cook County Hospitals (Strabismus) GRADUATE SCHOOL University of Illinois at Chicago (MS, Microbiology) Clinical Interests Management of complications of the Marfan syndrome and related connective tissue diseases; Clinical diagnosis of patients with rare genetic diseases of the visual system Research Interests Finding new genes and mutations in hereditary eye diseases through application of whole exome and whole genome sequencing strategies; Special interest in Leber congenital amaurosis Clinical Interests International ophthalmology with special interest in training issues in pediatric ophthalmology; Craniofacial syndromes; Teratology; Duane syndrome Research Interests Teratology: craniofacial anomalies; Duane syndrome OTHER CLINICAL FACULTY Javaneh Abbasian, MD Assistant Professor of Ophthalmology Kimberlee Curnyn, MD Lawrence Kaufman, MD, PhD R.V. Paul Chan, MD, MSc, FACS Felix Y. Chau, MD Assistant Professor of Clinical Ophthalmology Associate Professor of Clinical Ophthalmology Ben Ticho, MD Associate Professor of Clinical Ophthalmology SPECIALTY FACULTY Vinay K. Aakalu, MD, MPH Oculoplastic and Reconstructive Surgery Pediatric Retina Pediatric Retina OneVision | 21 RETINA The Retina Service specializes in treating patients with both medical and surgical retinal vascular and vitreoretinal disorders, such as: age-related macular degeneration, vein occlusion, sickle cell eye disease, ocular complications of diabetes, retinal detachment, vitreomacular adhesion, retinopathy of prematurity, retinitis pigmentosa, intraocular tumors and severe eye trauma. The doctors in this service are skilled specialists in laser and other medical treatment of the retina, vitreoretinal surgery and complex retinal detachment repair. DIRECTOR Jennifer I. Lim, MD, FARVO Marion H. Schenk Esq Chair in Ophthalmology for Research of the Aging Eye Professor of Ophthalmology Director, Retina Service MEDICAL SCHOOL Northwestern University RESIDENCY IN OPHTHALMOLOGY Illinois Eye and Ear Infirmary CLINICAL FELLOWSHIP Wilmer Eye Institute (Retina) Clinical Interests Diabetic retinopathy; Age-related macular degeneration; Retinal vascular diseases; Macular diseases; Retinal detachments and vitreoretinal disorders; Ocular tumors; Retinal degenerations Research Interests Medical and surgical treatments; Clinical trials to evaluate new medical and surgical treatments of retinal diseases; Retinal imaging as applied to management of retinal diseases and determination of pathophysiology; Collaborative projects with basic scientists on pathogenesis of retinal diseases IMAGE: Immunofluorescence image of retinal cell layers courtesy of the Vitreoretinal Microsurgery Laboratory. 22 Norman P. Blair, MD Professor of Ophthalmology Director, Laboratory of Retinal Circulation and Metabolism MEDICAL SCHOOL Indiana University RESIDENCY IN OPHTHALMOLOGY Massachusetts Eye & Ear Infirmary CLINICAL FELLOWSHIP Retina Associates/Massachusetts Eye & Ear Infirmary (Retina) CLINICAL FELLOWSHIP Illinois Eye and Ear Infirmary (Ophthalmic Pathology) RESEARCH FELLOWSHIP Schepens Eye Research Institute Research Interests Retinal oxygenation; Retinal energy metabolism; Retinal blood flow and ischemia; Diabetic retinopathy Yannek I. Leiderman, MD, PhD Assistant Professor of Ophthalmology Director, Vitreoretinal Microsurgery Laboratory MEDICAL SCHOOL George Washington University National Institutes of Health Partnership (PhD, Molecular Pathobiology) RESIDENCY IN OPHTHALMOLOGY Massachusetts Eye and Ear Infirmary CLINICAL FELLOWSHIP Massachusetts Eye and Ear Infirmary (Vitreoetinal Surgery) Clinical Interests Vitreoretinal surgical diseases; Diabetic eye disease; Complex retinal detachment; Proliferative vitreoretinopathy (PVR); Macular surgery; Treatment of aphakia and placement of secondary intraocular lenses Research Interests Effectiveness of ophthalmic surgical interventions in diseases of the retina and vitreous; High-fidelity modeling of novel surgical devices and experimental techniques in microsurgery Felix Y. Chau, MD Assistant Professor of Ophthalmology Director, Retinal Bioengineering Laboratory MEDICAL SCHOOL University of Iowa RESIDENCY IN OPHTHALMOLOGY Duke University Eye Center CLINICAL FELLOWSHIP Illinois Eye and Ear Infirmary (Retina) Clinical Interests Pediatric and adult retinal diseases; Retinopathy of prematurity (ROP); Retinoblastoma; Rare congenital and inherited retinal diseases; Proliferative vitreoretinopathy (PVR); Diabetic retinopathy; Macular degeneration; Cystoid macular edema Research Interests R. V. Paul Chan, MD, MSc, FACS Professor of Ophthalmology Vice Chair for Global Ophthalmology Co-Director Vitreoretinal Fellowship Training Program MEDICAL SCHOOL Temple University RESIDENCY IN OPHTHALMOLOGY New York-Presbyterian Hospital, Cornell University CLINICAL FELLOWSHIP Massachusetts Eye and Ear Infirmary (Retina) Clinical Interests Adult and pediatric retinal disease including retinopathy of prematurity (ROP); Retinal vascular diseases; Eye trauma; Eye infections/ endophthalmitis; Diabetic retinopathy; Age-related macular degeneration Medical and surgical treatments; Experimental models and risk factors for retinal diseases; Engineering applications in ophthalmology Research Interests William F. Mieler, MD, FARVO Lawrence J. Ulanski, MD, II Cless Family Professor in Ophthalmology Vice Chair for Education Director, Ocular Oncology Clinic Director, Residency and Vitreoretinal Fellowship Training MEDICAL SCHOOL University of Wisconsin-Madison RESIDENCY IN OPHTHALMOLOGY Bascom Palmer Eye Institute CLINICAL FELLOWSHIP Global ophthalmology; Telemedicine and teleeducation; New methods of diagnosing and managing pediatric retinal disease Assistant Professor of Clinical Ophthalmology MEDICAL SCHOOL University of Michigan RESIDENCY IN OPHTHALMOLOGY William Beaumont Eye Institute CLINICAL FELLOWSHIPS University of Toronto, (Vitreo-Retina and Ocular Oncology) Illinois Eye and Ear Infirmary (Uveitis) The Eye Institute, Medical College of Wisconsin (Retina-Vitreous) CLINICAL FELLOWSHIP Wills Eye Hospital (Ocular Oncology) Clinical Interests Diseases of the macula, retina and vitreous; Agerelated macular degeneration; Diabetic macular edema; Venous occlusive diseases; Vitreoretinal interface disorders; Ocular oncology Research Interests Ocular pharmacology; Intraocular tumors; Ocular imaging OneVision | 23 UVEITIS Uveitis causes up to 20 percent of blindness in the United States. The Uveitis Service treats patients with inflammation of the uveal tract, the middle vascular layers of the eye critical to its normal function. Because of the rich circulation of blood throughout this area and its proximity to other important parts of the eye, the uvea is susceptible to immune disorders. Patients are referred to this service for the diagnosis and management of infectious and non-infectious ocular inflammatory conditions such as scleritis and anterior, intermediate and posterior uveitis. Treatment with steroid-sparing systemic immunomodulatory therapy is offered when appropriate. The service also performs procedures for its uveitis patients such as the insertion of steroid eluting implants as well as surgical management of complex uveitic cataracts. CO-DIRECTOR CO-DIRECTOR Pooja Bhat, MD Ann-Marie Lobo, MD Assistant Professor of Ophthalmology Director, Uveitis Service MEDICAL SCHOOL Lokmanya Tilak Municipal Medical College and Hospital, India RESIDENCY IN OPHTHALMOLOGY Northwestern University CLINICAL FELLOWSHIPS Northwestern University (Uveitis) Massachusetts Eye and Ear Infirmary (Ophthalmic Pathology) RESEARCH FELLOWSHIP Massachusetts Eye Research and Surgery Institution (Uveitis) Clinical Interests Scleritis; Anterior, intermediate and posterior uveitis; VogtKoyanagi-Harada (VKH) disease; Behcet’s syndrome; Sarcoidosis; Infectious retinopathies; White dot syndromes Research Interests Systemic immunosuppression for ocular inflammatory conditions; Seasonal variations in autoimmune diseases; Disc and scleral changes in VKH; Schisis in pars planitis; Anterior segment and posterior segment imaging with optical coherence tomography 24 Assistant Professor of Ophthalmology MEDICAL SCHOOL Louisiana State University New Orleans RESIDENCY IN OPHTHALMOLOGY Massachusetts Eye and Ear Infirmary CLINICAL FELLOWSHIP (OCULAR IMMUNOLOGY/UVEITIS) Massachusetts Eye and Ear Infirmary Clinical Interests Ocular inflammatory disease, including infectious and non-infectious uveitis, scleritis and ocular surface inflammation; Cataract surgery Research Interests Diagnostic testing in infectious and non-infectious uveitis; Outcomes of biologic response modifier therapies in the treatment of uveitis; Morbidity of childhood uveitis; Systemic infections and eye disease IMAGE: Colorized OCT image of VKH patient’s retina courtesy of the Uveitis Service. LOW VISION PATHOLOGY This specialized service introduces patients with low vision to technology and techniques to enhance their remaining sight and facilitate their independence. A low-vision optometrist and a certified low-vision therapist work as a team to provide clinical examination and visual skills assessment. Therapies include special optical and electronic devices, ergonomic equipment and new visual skills training to address routine daily tasks such as reading, writing, managing medication, cooking, locating and sign reading. The Ophthalmic Pathology Laboratory is a joint program of the Departments of Pathology and Ophthalmology that provides diagnostic services to patients and physicians within and outside Illinois. The laboratory is integrated with the other clinical laboratories in the University of Illinois Hospital and Health Sciences System, making it possible to utilize the latest cutting-edge diagnostic techniques in immunopathology and molecular pathology available in the diagnosis of ocular disorders. DIRECTOR DIRECTOR Joan A. Stelmack, OD, MPH Amy Y. Lin, MD OPTOMETRY SCHOOL MEDICAL SCHOOL GRADUATE SCHOOL RESIDENCY Associate Professor of Clinical Ophthalmology Director, Low Vision Service Illinois College of Optometry Johns Hopkins University (MPH) Clinical Interests Rehabilitation of patients with vision loss Research Interests Creating multicenter clinical trials and observational studies to evaluate rehabilitation strategies and devices to restore or enhance vision Assistant Professor of Ophthalmology and Pathology Director, Ophthalmic Pathology Laboratory Johns Hopkins University Illinois Eye and Ear Infirmary (in Ophthalmology) University of Illinois College of Medicine (in Pathology) CLINICAL FELLOWSHIP (OPHTHALMIC PATHOLOGY) Illinois Eye and Ear Infirmary Clinical Interests Eye pathology; Pathologic basis of ophthalmic disease Research Interests Ocular oncology; Pathology education; Virtual microscopy for learning pathology; Team-based learning OneVision | 25 COMPREHENSIVE OPHTHALMOLOGY FACULTY PRACTICE (COFP) The Comprehensive Eye Clinic is a premiere ophthalmology practice run by recognized Board Certified ophthalmologists. The clinic provides: comprehensive eye exams, eyeglass prescriptions and contact lens fitting. The more extensive services include: state-of-the-art cataract surgery, femtosecond laser assisted cataract surgery, premium intraocular lenses and the management of common and complex eye diseases. Same-day or next-day appointments are available. GENERAL EYE CLINIC (GEC) The General Eye Clinic is the heart of our department and serves as the first point of contact for many of the Infirmary’s neediest patients, as well as a primary location for ophthalmic graduate medical education. Our dedicated residents and world-class faculty provide a wide spectrum of collaborative ophthalmic care ranging from managing common eye diseases and delivering routine eye exams to performing complex medical and surgical cases including cataract, glaucoma and retinal procedures. Special emphasis is placed on providing strong continuity of patient care. The GEC sees emergent referrals from outside providers from throughout the region and accepts “walk-in” patients with acute eye disease. DIRECTOR M. Soledad Cortina, MD (Cornea) Assistant Professor of Ophthalmology Director, COFP and GEC Director, Artificial Cornea Program COFP FACULTY Jose de la Cruz, MD Sandeep Jain, MD (Cornea) (Cornea) Timothy McMahon, Ellen Shorter, OD, OD, FAAO FAAO (Contact Lens) (Contact Lens) Ahmad Aref, MD (Glaucoma) Pooja Bhat, MD (Uveitis) Ali Djalilian, MD (Cornea) Bryan Kim, MD (Cornea) Ann-Marie Lobo, MD (Uveitis) Peter Macintosh, MD (Neuro-Oph and Oculoplastics) Mark Rosenblatt, MD, PhD, MBA (Cornea) Joel Sugar, MD (Cornea) Elmer Tu, MD (Cornea) Charles Yu, MD (Cornea) GEC FACULTY Anthony G. Finder, MD Assistant Professor of Clinical Ophthalmology MEDICAL SCHOOL Northwestern University RESIDENCY IN OPHTHALMOLOGY Michael Reese Hospital and Medical Center Clinical Interests General Ophthalmology; Early diagnosis and medical management of glaucoma; Analysis of problems related to ophthalmic optics and refraction; Resident education 26 MILLENNIUM PARK EYE CENTER (MPEC) The Millennium Park Eye Center (MPEC) is the conveniently located city-center clinic of the Illinois Eye and Ear Infirmary. Ophthalmologists and Optometrists seeing patients at the MPEC are all members of the Department of Ophthalmology & Visual Sciences faculty. They diagnose and treat a wide range of eye conditions every day, from common eye problems to the most complex ophthalmic issues. The center utilizes the most advanced eye care technology in vision care available, with state-of-the-art diagnostic and surgical instruments. IMAGE: Cloud Gate sculpture in Chicago’s Millennium Park. Photographer: James Pharaon at iStock. CO-DIRECTOR CO-DIRECTOR Jose de la Cruz, MD (Cornea) Pete Setabutr, MD (Oculoplastic & Reconstructive Surgery) Ahmad Aref, MD (Glaucoma) Dimitri Azar, MD, MBA (Cornea) R. V. Paul Chan, MD, Nathalie Azar, MD (Pediatric Ophthalmology MSc, FACS (Retina) & Adult Strabismus) Timothy McMahon, OD, FAAO (Contact Lens) William Mieler, MD (Retina) Heather Moss, MD, PhD (NeuroOphthalmology) Mark Rosenblatt, MD, PhD, MBA (Cornea) OneVision | 27 RESEARCH FACULTY The Department of Ophthalmology and Visual Sciences has a history of dedicated commitment and record of prominent contributions to vision science research. The overarching goal for the research program is to address the significant challenges central to understanding, treating and preventing blinding eye disease. The program encompasses exemplary and pioneering research in the most critical areas of vision research, including investigations to understand the mechanisms of potentially blinding eye diseases, the development of innovative techniques and instruments for diagnosing and monitoring the progression of eye diseases, genome-wide association studies, visual psychophysics, retinal processing, and visual neurophysiology. The department maintains a tradition of excellence in collaborative and interdisciplinary research that has advanced knowledge in basic vision science and facilitated translation of findings to improve clinical care of patients with eye diseases. Mahnaz Shahidi, PhD Vice Chair and Research Director Morton F. Goldberg Professor of Ophthalmology Professor of Physics and Bioengineering Director, Applied Physics Laboratory GRADUATE SCHOOL University of Illinois at Chicago (MS, PhD, Atomic and Molecular Physics) Research Interests Development and application of optical imaging systems for quantitative assessment of eye diseases, including diabetic retinopathy, age-related macular degeneration and sickle cell retinopathy Dingcai Cao, PhD Xiaoyi “Raymond” Gao, PhD GRADUATE SCHOOL GRADUATE SCHOOL Associate Professor of Ophthalmology Director, Visual Perception Laboratory Beijing University (MS, Biopsychology) University of Chicago (MS, Statistics) University of Chicago (PhD, Biopsychology) Research Interests Melanopsin-based visual perception and circadian rhythm; Rod-cone Interaction; Color perception; Retinal physiology; Lighting and health; Acute and chronic alcohol effect on vision and circadian rhythm IMAGE: OCT image with retinal layers delineated courtesy of the Applied Physics Laboratory. 28 Associate Professor of Ophthalmology Director, Quantitative Ocular Genomics Laboratory North Carolina State University (PhD, Bioinformatics-Statistics) RESEARCH FELLOWSHIPS Duke University Center for Human Genetics Miami Institute for Human Genomics Research Interests Ocular genomics; Glaucoma; Diabetic retinopathy; Age-related macular degeneration; Human genetics; Statistical genomics; Bioinformatics Joelle A. Hallak, PhD Assistant Professor of Ophthalmology Executive Director, Ophthalmology Center for Clinical Trials and Translational Studies GRADUATE SCHOOL University of Illinois at Chicago (MS, PhD, Epidemiology) Research Interests Ocular epidemiological research; Mental health; biological and genetic markers; Comparative effectiveness research and statistical analysis of complex data David R. Pepperberg, PhD, FARVO Searls-Schenk Professor of Ophthalmology Director, Photoreceptor Research Laboratory GRADUATE SCHOOL Massachusetts Institute of Technology (PhD, Biophysics) RESEARCH FELLOWSHIP Harvard University (Vision Physiology) Research Interests Developing new molecular therapies that delay the progression of, and restore vision lost in, photoreceptor degenerative diseases such as agerelated macular degeneration (AMD) Nalin M. Kumar, DPhil Professor of Ophthalmology GRADUATE SCHOOL University of Oxford, UK (DPhil Biochemistry) RESEARCH FELLOWSHIP Baylor College of Medicine (Cell and Molecular Biology) Research Interests Intercellular channels (gap junctions) and their involvement in the processes and mechanisms that are necessary for vision Deepak Shukla, PhD Marion H. Schenk Esq. Professor in Ophthalmology for Research of the Aging Eye Professor of Ophthalmology, Microbiology and Immunology Director, Ocular Virology Laboratory J. Jason McAnany, PhD Assistant Professor of Ophthalmology Director, Clinical Psychophysics and Electrophysiology Laboratory GRADUATE SCHOOL University of Illinois at Chicago (MA, PhD, Behavioral Neuroscience) RESEARCH FELLOWSHIP University of Illinois College of Medicine (Psychophysics and Electrophysiology) Research Interests Electroretinography; Psychophysics; Pupillometry; Retinal imaging; Acquired and inherited retinal disease Xincheng Yao, PhD Professor of Bioengineering and Ophthalmology Director, Biomedical Optics and Functional Imaging Laboratory GRADUATE SCHOOL University of Illinois at Chicago (PhD , Microbiology and Immunology) Harbin Institute of Technology, China (MEng, Optical Instrumentation) Institute of Physics Chinese Academy of Sciences (PhD, Optics) RESEARCH FELLOWSHIP Research Interests GRADUATE SCHOOL Northwestern University (Virology and Immunology) Biomedical optics; Retinal imaging; Experimental biophysics Research Interests Ocular herpes virus infection mechanisms; Development of new therapeutic strategies against viral diseases of the aging eye; Herpes virus vaccine development OneVision | 29 RESEARCH FACULTY (CONTINUED) Jin-Hong Robert Chang, PhD Research Assistant Professor of Ophthalmology Director, Angiogenesis Research Laboratory GRADUATE SCHOOL University of Mississippi (PhD, Biochemistry) RESEARCH FELLOWSHIP University of Virginia (Microbiology) Research Interests The role of VEGFR1, R2 and R3 activity in vitro and in vivo with the broader goal of characterizing the intrinsic factors of lymphatic cells that regulate corneal angiogenesis and lymphangiogenesis; Development of targeted therapies for corneal injury and disease Research Assistant Professor of Ophthalmology Corneal Epithelial Biology and Tissue Engineering Laboratory MEDICAL SCHOOL Tehran University of Medical Sciences, Iran RESEARCH FELLOWSHIP University of Illinois College of Medicine (Biology and Tissue Engineering) Research Interests Translational studies in ocular surface disease; Limbal stem cell deficiency; Refractive surgery; Clinical trials and population-based studies; Mesenchymal stem cell based therapy; Corneal innate immunity Victor H. Guaiquil, PhD Kyu Yeon Han, PhD GRADUATE SCHOOL GRADUATE SCHOOL Assistant Research Professor of Ophthalmology Corneal Regenerative Medicine Laboratory University Austral, Chile (MS) SUNY Downstate Medical Center, New York (PhD, Molecular and Cellular Biology) RESEARCH FELLOWSHIPS Memorial Sloan-Kettering Cancer Center Hospital for Special Surgery, New York Research Interests Cellular and molecular mechanisms involved in angiogenesis and neurogenesis in the retina and cornea; Cornea nerve regeneration; Oxygen induced retinopathy 30 Medi Eslani, MD Research Assistant Professor of Ophthalmology Metalloproteinases Research Laboratory Michael A. Grassi, MD Research Associate Professor of Ophthalmology Director, Retinal Chemical Genomics Laboratory MEDICAL SCHOOL Northwestern University RESIDENCY IN OPHTHALMOLOGY University of Iowa CLINICAL FELLOWSHIP University of Iowa (Medical Retina) RESEARCH FELLOWSHIP University of Iowa (Molecular Ophthalmology) Research Interests Improving the treatment of retinal disease; Using cell-based models of retinal disease in genomic and chemical high throughput studies to identify key pathways and novel therapeutic targets Zeeshan Pasha, MD, PhD, MPH Research Assistant Professor of Ophthalmology Corneal Regenerative Medicine Laboratory Lacrimal Cell Biology Laboratory Suwon University, Korea (MS, Genetic Engineering) Kyung Hee University, Korea (PhD, Oncology) MEDICAL SCHOOL RESEARCH FELLOWSHIP GRADUATE SCHOOL Research Interests RESEARCH FELLOWSHIP University of Illinois College of Medicine (Ophthalmology) Vascular angiogenesis in vitro and in vivo; The function of membrane type I metalloproteinase in cornea angiogenesis Bahuddin Zakaryia University, Pakistan University of Punjab, Pakistan (PhD, Stem Cell Therapy) University of Illinois at Chicago (MPH) University of Illinois at Chicago (Pharmacology) Research Interests Stem cell based therapeutics; Induced pluripotent, adult and embryonic stem cells; Regenerative medicine; Small molecules; Angiogenesis; Drug screening; Clinical Trials; Translational research RESEARCH FACULTY (CONTINUED) Joy Sarkar, PhD Research Assistant Professor of Ophthalmology Corneal Neurobiology Laboratory GRADUATE SCHOOL University of Mumbai (MS, Microbiology) HN Hospital and Research Center, India (PhD, Biochemistry) RESEARCH FELLOWSHIPS Tata Institute of Fundamental Research, India (Biology) Northwestern University (Cellular and Molecular Biology) Research Interests Molecular and cellular aspects of dry eye disease; Innate immune mechanisms in dry eye; Role of neutrophil extracellular traps (NETS) and regulatory mechanisms in dry eye; Corneal nerve regeneration after injury Wallace Chamon, MD Charles Kinnaird, OD Paul Knepper, MD, PhD Anthony Peter Adamis, MD Eric C. Beyer, MD, PhD Michael Cho, PhD Lisa Ebihara, MD, PhD Gerald Fishman, MD Robert Folberg, MD Craig Foster, PhD David Freedman, PhD Ken-Ichiro Fukuchi, MD, PhD Richard A. Gemeinhart, PhD Debra Goldstein, MD John R. Hetling, PhD Yulia Komarova, PhD Jie Liang, PhD Kirk Packo, MD Robert Paul Malchow, PhD Asrar Malik, PhD Sekhar Reddy, PhD Daniel Roberts, OD, PhD Steven Roth, MD Alfred Rosenbloom, OD William H. Seiple, PhD Michael Shapiro, MD Murray Sherman, PhD Satoru Suzuki, PhD Janet P. Szlyk, PhD Howard Tessler, MD Vaibhav Tiwari, PhD Kimani Toussaint, PhD Kazuo Tsubota, MD Xiaojing Yang, PhD CLINICAL VOLUNTEER FACULTY ADJUNCT FACULTY Norma Allemann, MD AFFILIATED & JOINT COURTESY FACULTY Molly Gilbert, MD Daniel Alter, MD, PhD David Badawi, MD Adrienne Berman, MD Harit Bhatt, MD Michael Blair, MD Rebekah Braslow, MD Victoria Butcko, OD Robert Egel, MD Steven Eiden, OD Timothy Flood, MD Enrique Garcia-Valenzuela, MD Jon Gieser, MD Daniel Greenberg, MD Jingtao Guo, MD Rama Jager, MD, MBA Katherine Hare, MD Bruce Kaplan, MD Manali D. Kalra, MD Yuri Kim Kerns, MD Bryan Kim, MD Spero Kinnas, MD Timothy Kisla, DO Sheridan Lam, MD Janet Lee, MD David Lubeck, MD Smajo Osmanovic, MD Anna Park, MD Rakhi Patil, MD Michael Paxhia, MD Richard Quinones, MD Pervez Rasul, MD Kenneth Resnick, MD Alfred Rosenbloom, OD Veeral Sheth, MD Sriram Sonty, MD Thomas Stelmack, OD Daniel Tepper, MD Charles Vygantas, MD Robert Weiss, MD Chloe Winterbotham, MD IMAGE: Immunofluorescence image of conjunctival epithelium cells in ptosis surgical specimens courtesy of the Lacrimal Cell Biology Laboratory. OneVision | 31 SPONSORED RESEARCH July 1, 2013 – June 30, 2015 FEDERALLY SPONSORED GRANTS 32 INVESTIGATOR PROJECT TITLE FUNDING SOURCE Vinay Aakalu, MD, MPH Study of Accessory Lacrimal Gland and Precursor Cell Biology National Eye Institute Dimitri Azar, MD, MBA UIC K12 Independent Clinical Vision Scientist Development Program National Eye Institute Dimitri Azar, MD, MBA Metalloproteinase Expression in Corneal Wound National Eye Institute Dingcai Cao, PhD Alcohol Stimulations and Sedation in Binge Drinkers National Institute of Alcohol Abuse and Alcoholism * Dingcai Cao, PhD Neural Stem Cell Based Virotherapy for Malignant Glioma National Institute of Neurological Disorders and Stroke* Dingcai Cao, PhD Regulatory T Cells in Malignant Glioma National Cancer Institutes* Dingcai Cao, PhD Rod-Cone Interactions in Mesopic Vision National Eye Institute Jin-Hong Robert Chang, PhD Endostatin-derived Short Peptides in Corneal Transplantation Department of Veterans Affairs Jin-Hong Robert Chang, PhD VEGFR2 modulates corneal angiogenesis and lymphangiogenesis National Eye Institute Jin-Hong Robert Chang, PhD Inhibition of VEGF receptor dimerization and signaling in corneal lymphangiogenesis National Eye Institute Ali Djalilian, MD Clinical Translation of Mesenchymal Stem Cell Therapy for Corneal and Ocular Surface Injuries Department of Defense Xiaoyi Raymond Gao, PhD Mexican American Glaucoma Genetic Study National Eye Institute Michael Grassi, MD Diabetes Complications Pilot and Feasibility Study: Regulators that Mediate the Cellular Response to Chronic Hyperglycemia National Institute of Diabetes and Digestive and Kidney Diseases * Michael Grassi, MD Genomic and Genetic Studies of Diabetic Retinopathy National Eye Institute Sandeep Jain, MD Molecular and cellular aspects of corneal nerve regeneration National Eye Institute Sandeep Jain, MD Keratocyte Role in Guidance of Corneal Nerves National Eye Institute Charlotte Joslin, OD, PhD Local Food Environments and Disparities in Ovarian Cancer Survival National Institute on Minority Health and Health Disparities Iris Kassem, MD, PhD Fibrosis and Inflammation After Anterior Segment Surgery National Eye Institute J. Jason McAnany, PhD Mechanisms Limiting Visual Performance in Retinal Degenerations National Eye Institute Heather Moss, MD, PhD Physiologically Based Markers of Idiopathic Intracranial Hypertension National Eye Institute David Pepperberg, PhD Nanoparticle-based Photo-activator of Voltage-gated Sodium Channels National Eye Institute Mark Rosenblatt, MD, PhD, MBA Mechanisms of Corneal Nerve Repair National Eye Institute Mark Rosenblatt, MD, PhD, MBA Molecular and Functional Characterization of the Regenerative Potential of Slow Cycling Corneal Epithelial Cells National Eye Institute Mark Rosenblatt, MD, PhD, MBA Corneal Tissue Engineering National Eye Institute* Mahnaz Shahidi, PhD Ocular Biomarkers of Microvascular, Neural and Metabolic Function in Diabetes National Institute of Diabetes and Digestive and Kidney Diseases Mahnaz Shahidi, PhD Noninvasive Imaging Of Chorioretinal Oxygen Tension National Eye Institute Mahnaz Shahidi, PhD P30 Core grant for Vision Research National Eye Institute Mahnaz Shahidi, PhD Investigating Optical and Neural Causes of Vision Loss Department of Veterans Affairs Deepak Shukla, PhD Novel Peptides Against Modified Heparan Sulfate National Institute of Allergy and Infectious Diseases Deepak Shukla, PhD Micro-nano platforms for HSV vaccine National Institute of Allergy and Infectious Diseases Deepak Shukla, PhD Significance of Heparan Sulfate in HSV-1 Spread National Institute of Allergy and Infectious Diseases Deepak Shukla, PhD and Beatrice Yue, PhD Role of Optineurin in Ocular Herpes Infection National Eye Institute Elmer Tu, MD Planning Grant for Parasitic Ulcer Treatment Trial Consortium National Eye Institute* Thasarat Vajaranant, MD Optic Nerve Aging and Glaucoma National Eye Institute Beatrice Yue, PhD Cellular Processing of Optineurin The Product of a Glaucoma Gene National Eye Institute Xincheng Yao, PhD Functional Imaging of Retinal Photoreceptors National Eye Institute Xincheng Yao, PhD Super-Resolution Ophthalmoscopy for In Vivo Retinal Imaging National Eye Institute FOUNDATION SPONSORED RESEARCH INVESTIGATOR PROJECT TITLE FUNDING SOURCE Vinay Aakalu, MD, MPH Study of Accessory Lacrimal Gland and Precursor Cell Biology Fight for Sight Vinay Aakalu, MD, MPH Development of an in vitro Model of Lacrimal Cells using Stem Cells Midwest Eye-Banks Vinay Aakalu, MD, MPH Accessory Lacrimal Tissue Precursor Cell Biology Illinois Society for the Prevention of Blindness Vinay Aakalu, MD, MPH Lacrimal Stem Cells and Dry Eye Research American Society of Cataract and Refractive Surgery Pablo Barrionuevo, PhD (Cao) Melanopsin Photoresponse Deficit in Glaucoma Illinois Society for the Prevention of Blindness Joseph Bogaard (Grassi) CYP2C9 Mediated Neuroprotection in Retinal Degenerative Disease Illinois Society for the Prevention of Blindness Dingcai Cao, PhD Mesopic Visual Function Assessment and Risk Genotypes for Age-related Macular Degeneration Midwest Eye-Banks Dingcai Cao, PhD Alcohol Effects on Visual Processing in At-Risk Social Drinkers ABMRF/The Foundation for Alcohol Research Dingcai Cao, PhD Postdoctoral Fellowship International Brain Research Organization Ali Djalilian, MD Clinical Translation of Mesenchymal Stem Cell Trophic Factors for the Corneal Disease in Aniridia Vision For Tomorrow Andrew Francis, MD (Shahidi) Abnormalities in Retinal Layer Thickness due to Diabetes Assessed with Spectral Domain Optical Coherence Tomography Illinois Society for the Prevention of Blindness Xiaoyi Raymond Gao, PhD Fine Mapping of Genetic Loci for Central Corneal Thickness Midwest Eye-Banks Michael Grassi, MD Cellular Studies of Apoptosis in RP Using Small Molecule Screening and RNA Interference Foundation Fighting Blindness Joshua Hou, MD (Cortina) Comparison of Ocular Surface Flora in Boston Keratoprosthesis Patients on Prophylactic Vancomycin vs. Linezolid American Society of Cataract and Refractive Surgery Joshua Hou, MD (Cortina) Characterization of Melt-associated Retroprosthetic Membranes in Patients with the Boston Keratoprosthesis using Immunohistochemistry and In-situ Hybridization Illinois Society for the Prevention of Blindness Sandeep Jain, MD Physician-Scientist Award Research to Prevent Blindness, Inc. Sandeep Jain, MD Safety and Efficacy of DNase I Eye Drops in Dry Eye Disease Midwest Eye-Banks Sachin Jain, MD (Vajaranant) Functional Measures as Surrogates for Vision-related Quality of Life in Patients with Glaucoma Illinois Society for the Prevention of Blindness Charlotte Joslin, OD, PhD Racial Disparities in Ovarian Cancer Survival American Cancer Society Iris Kassem, MD, PhD Fibrin Membrane Formation and Inflammation After Pediatric Ocular Surgery Knights Templar Eye Foundation Behard Milani, MD (Djalilian) The Use of Rapamycin as an Additive to Corneal Storage Media Eye Bank Association of America Heather Moss, MD, PhD Ganglion Cell Function in Papilledema Illinois Society for the Prevention of Blindness Paul Park (Shukla) Medical Student Fellowship: Comparative Analysis of Prophylactic and Therapeutic Efficacies of Anti-Heparan Sulfate Peptides in Previously HSV-1 Infected Corneal Cells Fight for Sight Rajni Parthasarathy (Pepperberg) Detection and Quantification of Amyloid-Beta Protein in Eye Tissues Illinois Society for the Prevention of Blindness David Pepperberg, PhD Exogenous Peptidase for Amylod-beta Degradation BrightFocus Foundation David Pepperberg, PhD Nanoprosthesis for Retinal Ganglion Cell Photo-activation Beckman Initiative for Macular Research Mark Rosenblatt, MD, PhD, MBA Research to Prevent Blindness, Inc. Unrestricted Departmental Grant Research to Prevent Blindness, Inc. Joy Sarkar, PhD (Jain) Extracellular DNA in Tear Fluid: Innate Mechanism of Ocular Surface Inflammation Illinois Society for the Prevention of Blindness Mahnaz Shahidi, PhD Senior Scientific Investigator Award Research to Prevent Blindness, Inc. Deepak Shukla, PhD Developing a NSV-2 Vaginal Microbicide that also serves as a Vaccine Center for Clinical and Translational Science Sapna Tibrewal, MD (Jain) Role of Neutrophils in Pathogenesis of Chronic Ocular Graft-versus-Host Disease Illinois Society for the Prevention of Blindness Elmer Tu, MD Microbial Clearance Time for Acanthamoeba Keratitis Research to Prevent Blindness, Inc.* Thasarat Vajaranant, MD A Feasibility Study to Assess the Accuracy of Self-Reported Glaucoma Outcomes and Participant Interest in Ancillary Glaucoma Studies as Part of the Women’s Health Initiative (WHI) Extension American Glaucoma Society Gautam Vangipuram (Moss) Association Between Retinal Vessel Size and Short Term Intracranial Pressure Changes in Idiopathic Intracranial Hypertension Illinois Society for the Prevention of Blindness Hongyu Ying, PhD Suppression of Ocular Fibrosis by SiRNA-Nanoparticle Technology Illinois Society for the Prevention of Blindness Beatrice Yue, PhD Fibril/Oligomer Formation by Optineurin in Vitro BrightFocus Foundation Jimmy Zhu (R. Chang) Differential Vascular Formation in Corneal Transplant Rejection Illinois Society for the Prevention of Blindness *Subcontracts OneVision | 33 CLINICAL INVESTIGATIONS AND TRIALS CORNEA Soledad Cortina, MD Study of Infectious Agents in Keratoprosthesis Implanted Eyes, their Biofilm Forming Capabilities and Infectious Complications Jose de la Cruz, MD A Multi-Center, Randomized, Placebo-Controlled Evaluation of the Safety and Efficacy of the KXL System with VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes with Keratoconus (KXL-005) Sandep Jain, MD A Phase I/II Open-Label, Single-Center, Tolerability and Preliminary Efficacy Study Of Recombinant Human Deoxyribonuclease (Rhdnase) Eye Drops In Patients With Dry Eye Disease Sandep Jain, MD Symptom Analysis of Dry Eye Disease Sandep Jain, MD Polymorphism in Dry Eye and Depression Sandep Jain, MD Presence of Neutrophil Extracellular Traps (NETS) in Dry Eye Disease Sandep Jain, MD A Phase I/II Randomized Placebo-Controlled, Double-Blind, Single-Center, Tolerability and Preliminary Efficacy Clinical Trial of Recombinant Human Deoxyribonuclease (Rhdnase) Eye Drops in Patients with Ocular Graft-Vs-Host Disease Sandep Jain, MD A Prospective Study to Identify Bio-Markers that Predict Onset and Progression of Ocular Graft-Vs-Host Disease in Patients who Receive Allogeneic Hematopoietic Stem Cell Transplant Elmer Tu, MD Corneal Preservation Time Study Elmer Tu, MD Microbiological Clearance Time For Acanthamoeba Keratitis GLAUCOMA Ahmad Aref, MD Omega-3 Fatty Acid Nutritional Supplementation in the Treatment of Ocular Surface Disease Associated with Intraocular Pressure-Lowering Medications Ahmad Aref, MD Outcomes of Glaucoma Drainage Implant Surgery Ahmad Aref, MD Outcomes of Goniotomy Surgery Thasarat Vajaranant, MD A Feasibility Study to Assess the Accuracy of Self-Reported Glaucoma Outcomes and Participant Interest in Participating in Ancillary Glaucoma Studies in Women’s Health Initiative Thasarat Vajaranant, MD Surgical Menopause and Risk for Premature Aging of the Optic Nerve and Glaucoma Thasarat Vajaranant, MD Structural Assessment in Glaucoma Thasarat Vajaranant, MD The Efficacy and Safety of Bimatoprost SR in Patients with Open-Angle Glaucoma or Ocular Hypertension Thasarat Vajaranant, MD A Randomized, Multicenter, Double-Masked, Parallel-Group Study Comparing the Safety and Efficacy of BOL-303259-X 0.024% (Latanoprostene Bunod) Ophthalmic Solution with Timolol Maleate Ophthalmic Solution 0.5% in Subjects With Open-Angle Glaucoma or Ocular Hypertension APOLLO Study Thasarat Vajaranant, MD A Double-Masked, Randomized, Multi-Center, Active-Controlled, Parallel, 3-Month Study Assessing the Safety and Ocular Hypotensive Efficacy of AR-13324 Ophthalmic Solution, 0.02% Compared to Timolol Maleate Ophthalmic Solution, 0.5% in Patients with Elevated Intraocular Pressure Jacob Wilensky, MD Determining the Intraocular Presence of Benzylkonium Chloride NEURO-OPHTHALMOLOGY Heather Moss, MD, PhD P. MacIntosh Phase 2/3/ Research Study for the Treatment of Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) Heather Moss, MD, PhD; J. McAnany; M. Shahidi Physiologically Based Markers of Idiopathic Intracranial Hypertension Blue Font indicates Sponsored 34 Filled rows indicates Enrolling Patients OCULOPLASTIC SURGERY Vinay Aakalu, MD, MPH Study of Accessory Lacrimal Gland Biology RETINA Jennifer Lim, MD; F. Chau Ocriplasmin Research to Better Inform Treatment (ORBIT) Jennifer Lim, MD; F. Chau A Phase 2, Randomized, Double-Masked, Placebo-Controlled, Parallel Group, Multicenter Study to Compare the Efficacy and Safety of a Chemokine CCR2/5 Receptor Antagonist (PF-04634817) with that of Ranibizumab in Adult Subjects with Diabetic Macular Edema (Pfizer DME) Jennifer Lim, MD; F. Chau Study of Comparative Treatments for Retinal Vein Occlusion 2: A Multicenter, Prospective, Randomized Non-Inferiority Trial of Eyes with Macular Edema Secondary to Central Retinal Vein Occlusion, Comparing Intravitreal Bevacizumab every 4 Weeks with Intravitreal Aflibercept every 4 Weeks (SCORE2) Jennifer Lim, MD; F. Chau; W. Mieler Argus II Retinal Prosthesis System - Post-Approval Study (PAS) Jennifer Lim, MD; F. Chau; W. Mieler Argus II Retinal Prosthesis System - Humanitarian Use Device (HUD) Jennifer Lim, MD; F. Chau A Double-Masked, Randomized, Active-Controlled Study of the Efficacy, Safety, and Tolerability of Intravitreal Administration of VEGF Trap-Eye (Intravitreal Aflibercept Injection [IAI]) in Patients with Macular Edema Secondary to Branch Retinal Vein Occlusion Jennifer Lim, MD; F. Chau A Phase 3, Double-Masked, Randomized Study of the Efficacy and Safety of Intravitreal Aflibercept to Prevent Progression to Vision-Threatening Events in Patients with Diabetic Retinopathy (Regeneron VFGTe-OD-1411) Jennifer Lim, MD; F. Chau A Phase 2, Double-Masked, Randomized, Controlled, Multiple-Dose, Regimen-Ranging Study of the Efficacy and Safety of Intravitreal Regn2176-3 in Patients with Neovascular Age-Related Macular Degeneration (Regeneron R2176-3-AMD-1417) Jennifer Lim, MD; F. Chau Treatment for Central-Involved Diabetic Macular Edema in Eyes with Very Good Visual Acuity (Protocol V) Jennifer Lim, MD; F. Chau Genes in Diabetic Retinopathy Project (Protocol Genetics) Jennifer Lim, MD; F. Chau Peripheral Diabetic Retinopathy (DR) Lesions on Ultrawide-field Fundus Images and Risk of DR Worsening Over Time (Protocol AA) Jennifer Lim, MD; F. Chau Comparative Effectiveness Study of Aflibercept, Bevacizumab and Ranibizumab for Diabetic Macular Edema (Protocol T) Jennifer Lim, MD; F. Chau Intravitreal Ranibizumab or Triamcinolone Acetonide in Combination with Laser Photocoagulation for Diabetic Macular Edema (Protocol I) Jennifer Lim, MD; F. Chau Effect of Diabetes Education during Retinal Ophthalmology Visits on Diabetes Control (Protocol M) Jennifer Lim, MD; F. Chau An Evaluation of Intravitreal Ranibizumab for Vitreous Hemorrhage Due to Proliferative Diabetic Retinopathy (Protocol N) Jennifer Lim, MD; F. Chau Genetics of AMD in African Americans Jennifer Lim, MD; F. Chau An Experimental Approach to Maculopathy Jennifer Lim, MD; F. Chau Optical Coherence Tomographical Retinal Thickness Analysis of Sickle Cell Patients Jennifer Lim, MD; F. Chau Spatial Temporal Imaging of Human Bulbar Conjunctival Microvascular Blood Flow in Patients with Sickle Cell Disease Jennifer Lim, MD; F. Chau A Retrospective Case Series to Assess the Efficacy of Anti-VEGF Therapy in the Treatment of Macular Edema Secondary to Retinal Vein Occlusion Jennifer Lim, MD; F. Chau Retrospective Comparison between Bevacizumab (Avastin) and Ranibizumab (Lucentis) in Diabetic Macular Edema Jennifer Lim, MD; F. Chau Surgical Outcomes of 25-Gauge Vitrectomy for Tractional Retinal Detachment Jennifer Lim, MD; F. Chau Foveal Structure Integrity and Visual Outcome in Diabetic Retinopathy Jennifer Lim, MD; F. Chau Evaluation of Abicipar Pegol (AGN-150998) in Patients with Decreased Vision Due to Diabetic Macular Edema (PALM) Jennifer Lim, MD; F. Chau Systemic Immunosuppressive Therapy for Eye Diseases Cohort Study Jennifer Lim, MD; F. Chau Biomarkers in Proliferative Retinopathies (BPR) Lawrence Ulanski, MD Multi-Center, Randomized, Single Masked Phase 2 Study of Intravitreal Sirolimus in the Treatment of Central Geographic Atrophy Associated with Age-Related Macular Degeneration Lawrence Ulanski, MD Home Vision Monitoring in AREDS2 for Progression to Neovascular AMD Using the ForeseeHome Device Lawrence Ulanski, MD AMD Phenotype and Genotype Study (APGS) To learn more about any of these investigations and trials, including how to refer patients, please call (312) 996-6590. OneVision | 35 HONOR ROLL OF DONORS Fiscal Year 2014 (July 1, 2013 –June 30, 2014) $100,000+ Research to Prevent Blindness Inc. $50,000-99,999 American Health Assistance Foundation Foundation Fighting Blindness Dr. R. Mark and Mrs. Monica J. W. Hatfield Hope for Vision Komarek-Hyde-McQueen Foundation Dr. John H. (DEC) and Mrs. Mary K. Panton (DEC) Parent Petroleum, Inc. 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Zielinski OneVision | 37 OPHTHALMOLOGISTS IN TRAINING Residents 38 THIRD YEAR (Class of 2016) SECOND YEAR (Class of 2017) FIRST YEAR (Class of 2018) Judy Chen, MD | CO-CHIEF RESIDENT MD—University of Chicago Mohsin Ali, MD MD—Jefferson Medical College Julie Goldman, MD MD—Columbia University Eric Feinstein, MD MD—University of Virginia Susie Chen, MD MD—University of Wisconsin Shilpa Gulati, MD MD—University of Michigan Andrew Francis, MD MD—Boston University Mark Dikopf, MD MD—University of Illinois, Chicago Robert Hyde, MD, PhD MD/PhD—Case Western Reserve University Abed Namavari, MD MD—Tehran University Siya Huo, MD MD—Cleveland Clinic Lerner College of Medicine Alexander Pleet, MD MD—University of Pennsylvania Ketki Soin, MD | CO-CHIEF RESIDENT MD—Jefferson Medical College Kai Kang, MD MD—Weill Cornell Medical College Bailey Shen, MD MD—Case Western Reserve University Merina Thomas, MD MD—Vanderbilt University Mei Zhou, MD MD—University of Chicago Dan Yoon, MD MD—New York University Clinical Fellows CORNEA Claire Kelliher, MD MD—Trinity College Dublin Residency—Scheie Eye Institute CORNEA Peter Wu, MD MD—Texas Tech University Residency—University of California, Davis GLAUCOMA Sachin Jain, MD MD—University of Illinois, Peoria Residency—Illinois Eye and Ear Infirmary NEURO-OPHTHALMOLOGY Milena Stosic, MD MD—University of Belgrade Residency in Neurology—Baylor College of Medicine OCULOPLASTIC SURGERY Scott Jones, MD MD—University of Louisville Residency—Tulane University PEDIATRIC OPHTHALMOLOGY Majid Rouhbakhshzaeri, MD MD and Residency—Mashhad University of Medical Sciences RETINA Michael Andreoli, MD MD—Boston University Residency—Illinois Eye and Ear Infirmary RETINA Peter Chang, MD MD—Tufts University Residency—The New York Eye and Ear Infirmary CLASS OF 2014 RESIDENTS Front row: Drs. Kavitha Sivaraman, Randee Miller, Kevin Patel. Back row: Drs. Janet Lim, Senad Osmanovic, Adam Prickett CLASS OF 2015 RESIDENTS (left to right) Drs. Bryan Kim, Kaitlyn Wallace Nolan, Michael Andreoli, Sachin Jain and Asim Farooq RETINA Randee Miller, MD MD—Wayne State University Residency—Illinois Eye and Ear Infirmary OneVision | 39 FACULTY PUBLICATIONS Illinois Eye and Ear Infirmary Aakalu VK, Patel RM, Lim J, Setabutr P. Orbital histiocytic sarcoma in a 2-year-old child. Ophthal Plast Reconstr Surg. 2014 Nov-Dec;30(6):e143-5. Abbasian J, Blair N, Shahidi M, Kaufman L, Blair M, et al. Macular optical coherence tomography in patients with unilateral optic nerve hypoplasia. J AAPOS. 2015 Feb;19(1):57-61. Afsharkhamseh N, Movahedan A, Djalilian AR, et al. Cataract surgery in patients with ocular surface disease: An update in clinical diagnosis and treatment. Saudi J Ophthalmol. 2014 Jul;28(3):164-7. from natural image statistics. J Opt Soc Am A Opt Image Sci Vis. 2014 Apr 1;31(4):A131-9. Aref AA, Sayyad FE, Mwanza JC, et al. Diagnostic specificities of retinal nerve fiber layer, optic nerve head, and macular ganglion cell-inner plexiform layer measurements in myopic eyes. J Glaucoma. 2014 OctNov;23(8):487-93. Barrionuevo PA, McAnany JJ, Cao D, et al. Assessing rod, cone, and melanopsin contributions to human pupil flicker responses. Invest Ophthalmol Vis Sci. 2014 Feb 4;55(2):719-27. Aref AA, Scott IU. Twentyfour-hour intraocular pressure monitoring: it’s about time. JAMA Ophthalmol. 2013 Nov;131(11):1403-4. Agrawal H, Aref AA, Traish A, et al. A neonate with bilateral corneal opacities and glaucoma. Pediat Ann.2014 Feb;43(2):60-3. Aref AA, Sivaraman KR, Djalilian AR. Glaucoma Drainage Implant Surgery and Ocular Surface Transplant Graft Preservation. Semin Ophthalmol. 2015 May;30(3):210-3. Andreoli MT, Aakalu V, Setabutr P. Epidemiological trends in malignant lacrimal gland tumors. Otolaryngol Head Neck Surg. 2015 Feb;152(2):279-83. Aref AA. Generic drugs for the treatment of ocular conditions: changing the treatment landscape. Expert Rev Clin Pharmacol. 2014 Sep;7(5):551-3. Andreoli MT, Lim JI. Cotton-wool spots and retinal hemorrhages. Interferon-associated retinopathy. JAMA Ophthalmol. 2014 Apr 1;132(4):503-4. Asvat Y, Cao D, Africk JJ, et al. Feasibility and effectiveness of a community-based smoking cessation intervention in a racially diverse, urban smoker cohort. Am J Public Health. 2014 Sep;104 Suppl 4:S620-7. Andreoli MT, Lim JI. Optical coherence tomography retinal thickness and volume measurements in X-linked retinoschisis. Am J Ophthalmol. 2014 Sep;158(3):567-73. Andreoli MT, Yiu G, Hart L, et al. B-scan ultrasonography following open globe repair. Eye (Lond). 2014 Apr;28(4):381-5. Antoine TE, Jones KS, Shukla D, et al. Zebrafish: modeling for herpes simplex virus infections. Zebrafish. 2014 Feb;11(1):17-25. Antoine TE, Shukla D. Inhibition of myosin light chain kinase can be targeted for the development of new therapies against herpes simplex virus type-1 infection. Antivir Ther. 2014;19(1):15-29. Antoine TE, Yakoub A, Shukla D, et al. Zebrafish 3-O-sulfotransferase-4 generated heparan sulfate mediates HSV-1 entry and spread. PLoS One. 2014 Feb 3;9(2):e87302. Aref AA, Sayyad FE, Ayres B, et al. Acute bilateral angle 40 closure glaucoma induced by methazolamide. Clin Ophthalmol. 2013;7:279-82. Avery RL, Bakri SJ, Mieler WF, et al. Intravitreal injection technique and monitoring: updated guidelines of an expert panel. Retina. 2014 Dec;34 Suppl 12:S1-S18. Baldwin J, Shukla D, Tiwari V, et al. A role for 3-O sulfated heparan sulfate in promoting human cytomegalovirus infection in human iris cell. J Virol. 2015 May 1;89(9):5185-92. Baradaran-Rafii A, Shirzadeh E, Eslani M, et al. Optical correction of aphakia in children. J Ophthalmic Vis Res. 2014 Jan;9(1):71-82. Barmettler A, Nissanka N, Rosenblatt MI, et al. Magnetic systems for tarsorrhaphy. Ophthal Plast Reconstr Surg. 2014 Jul-Aug;30(4):305-8. Barrionuevo PA, Cao D. Contributions of rhodopsin, cone opsins, and melanopsin to postreceptoral pathways inferred Beleggia F, Li Y, Maumenee IH, et al., CRIM1 haploinsufficiency causes defects in eye development in human and mouse. Hum Mol Genet. 2015 Apr 15;24(8):2267-73. Bhat PV, Goldstein DA. Dexamethasone Intravitreal Implant (Allergan) for the Treatment of Noninfectious Uveitis. Expert Opinion on Orphan Drugs. 2014 Mar; 2(3): 301-10. Bhat PV, Goldstein DA. Review of the Latest Local Treatments for Uveitis. Expert Review of Ophthalmology. 2014 Oct.;9(5): 401-12. Bourne RR, Vision Loss Expert Group of the Global Burden of Disease Study [Lim JI, Joslin CE], et al., Prevalence and causes of vision loss in high-income countries and in Eastern and Central Europe: 1990-2010. Br J Ophthalmol. 2014. Boyer DS, V.I.S.I.O.N. Study Group [Lim JI, Mieler WF], et al. Effect of pegaptanib sodium 0.3 mg intravitreal injections (Macugen) in intraocular pressure: posthoc analysis from V.I.S.I.O.N. study. Br J Ophthalmol. 2014 Nov;98(11):1543-6. Boyer DS, Ozurdex MEAD Study Group [Ulanski LJ], et al. Three-year, randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with diabetic macular edema. Ophthalmology. 2014 Oct;121(10):1904-14. Bressler SB, Diabetic Retinopathy Clinical Research Network [Blair M, Lim JI], et al. Exploratory analysis of the effect of intravitreal ranibizumab or triamcinolone on worsening of diabetic retinopathy in a randomized clinical trial. JAMA Ophthalmol. 2013 Aug;131(8):1033-40. Bressler SB, ; Diabetic Retinopathy Clinical Research Network Investigators [Blair M, Lim JI], et al. Repeated intravitreous ranibizumab injections for diabetic macular edema and the risk of sustained elevation of intraocular pressure or the need for ocular hypotensive treatment. JAMA Ophthalmol. 2015 May;133(5):589-97. 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The role of toll-like receptor 4 in corneal epithelial wound healing. Invest Ophthalmol Vis Sci. 2014 Sep 2;55(9):6108-15. Farooq AV, Lim JI. Subconjunctival hemorrhages and retinal vascular abnormalities. JAMA Ophthalmol. 2015 Feb 1;133(2):217-8. Farooq AV, Tu EY, D’jalilian AR, Traish AS, Hou JH. Persistent staining of lattice lines after intraoperative trypan blue use in patients with lattice corneal dystrophy. Cornea. 2014 Nov;33(11):1235-7. Farooq AV, Patel RM, Lin AY, Setabutr P, Aakalu VK, et al.. Fungal Orbital Cellulitis: Presenting Features, Management and Outcomes at a Referral Center. Orbit. 2015 Jun;34(3):152-9. Farooq AV, Soin K, Moss HE. Alternating skew deviation in association with anti-glutamic acid decarboxylase antibodies. Neuroophthalmology. 2015;39(3):140-143. Epub 2015 May 13. Fawzi AA, Moss HE, Lowry JL, et al. Clinicopathologic report of ocular involvement in ALS patients with C9orf72 mutation. 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Giovingo M, Yue BY, Knepper PA, et al. sCD44 overexpression increases intraocular pressure and aqueous outflow resistance. Mol Vis. 2013 Nov 1;19:2151-64. Gowrisankaran S, McAnany JJ, Alexander KR. Poststimulus response characteristics of the human cone flicker electroretinogram. Vis Neurosci. 2013 Jul;30(4):147-52. Grassi MA, Rao V, Bogaard JD, et al. Genetic variation is the major determinant of individual differences in leukocyte endothelial adhesion. PLoS One. 2014 Feb 10;9(2):e87883. Grassi MA, Gao X, DCCT/EDIC Research Group, et al. Validity of self-report in type 1 diabetic subjects for laser treatment of retinopathy. Ophthalmology. 2013 Dec;120(12):2580-6. Grybauskas A, Yue BY, Knepper PA, et al. ABCB1 transporter and Toll-like receptor 4 in trabecular meshwork cells. Mol Vis. 2015 Mar 5;21:201-12. Guaiquil VH, Hewing NJ, Rosenblatt MI, et al. A murine model for retinopathy of prematurity identifies endothelial cell proliferation as a potential mechanism for plus disease. 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Yanoff & Duker’s Cataract and Refractive Surgery. W B Saunders Co, 2014. Alió JL, Azar DT. Difficult and complicated cases in refractive surgery. Berlin: Springer-Verlag, 2015. Ang LPK, Azar DT. LASEK and Epi-LASIK. In: Yanoff M, Duker JS, Azar DT, Rosen ES. Yanoff & Duker’s Cataract and Refractive Surgery. W B Saunders Co, 2014. Ang LPK, Azar DT. Laser Subepithelial Keratomileusis (LASEK) and Epi-LASIK. In: Yanoff M, Duker JS. Ophthalmology (4th ed). Pittsburgh: Elsevier/ Saunders, 2014. Aref AA, Vajaranant TS. Management of glaucoma associated with Boston KPro Type I implantation. In: Cortina MS, de la Cruz J, eds. Keratoprostheses and Artificial Corneas: Fundamentals and Surgical Applications. Berlin: Springer-Verlag, 2015. Aref AA, Varma, R, eds. Advanced Glaucoma Surgery. Basel: Birkhauser Verlag AG, 2015. Aref AA. What are pearls for the postoperative management of trabeculectomy and its associated complications? Curbside Consultation in Glaucoma: 49 Clinical Questions, 2nd ed. Gedde SJ, Panarelli JF, Lewis RA, Heuer DK, eds. Slack, Inc, 2015:193-196. Assil KK, Hallak JA, Azar DT. Astigmatic and radial incisional keratotomy. In: Yanoff M, Duker JS. Ophthalmology (4th ed). Pittsburgh: Elsevier/Saunders, 2014. Assil KK, Hallak JA, Azar DT. Astigmatic and radial incisional keratotomy. In: Yanoff M, Duker JS, Azar DT, Rosen ES. Yanoff & Duker’s Cataract and Refractive Surgery. W B Saunders Co, 2014. Azar DT. Clinical Optics. (Basic and clinical science course, Sec. 3) San Francisco, American Academy of Ophthalmology & European Board of Ophthalmology, 2013. Azar DT. Refractive surgery (Section Editor: Part 3). In: Yanoff M, Duker JS. Ophthalmology (4th ed.) Pittsburgh: Elsevier/Saunders, 2014. Barnes SD, Hallak J, Pavan-Langston D, Azar DT. Microbial keratitis (Ch 15). In: Bennett JE, Dolin R, Blaser MJ. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. 8th ed. Philadelphia, PA : Elsevier/Saunders, 2015. Barnes SD, Kumar N, Pavan-Langston D, Azar DT. Microbial conjunctivitis (Ch 14) In: Bennett JE, Dolin R, Blaser MJ. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. 8th ed. Philadelphia, PA : Elsevier/Saunders, 2015. Batta P, Wadia HP, Sugar J. Corneal and external eye manifestations of systemic disease. In: Yanoff M, Duker JS. Ophthalmology (4th ed.) Pittsburgh: Elsevier/Saunders, 2014. Bhasin A. Djalilian AR, Movahedan A. Integrated artificial corneas: current developments. In: Cortina MS, de la Cruz J, eds. Keratoprostheses and Artificial Corneas: Fundamentals and Surgical Applications. Berlin: Springer-Verlag, 2015. Bui KM, Leiderman YI. Photodynamic therapy for neovascular age-related macular degeneration. In: Lim JI, ed. Age-Related Macular Degeneration. 3rd rev. ed. Boca Raton: CRC Press/Taylor & Francis Group, 2013. Chau FY, Wallace D, Vajaranant T, Herndon L, Lee PP, Challa P, Allingham R, Maumenee I. Osteogenesis Imperfecta and the eye. In: Shapiro JR, Byers PH, Glorieux FH, Sponseller PD (eds.) Osteogenesis Imperfecta: A Translational Approach to Brittle Bone Disease. Amsterdam: Academic Press, 2013. Chow CC, Lim JI, Modi D, Klesert TR, Rosenfeld PJ. Anti-VEGF drugs and clinical trials. In: Lim JI, ed. Age-Related Macular Degeneration. 3rd rev. ed. Boca Raton: CRC Press/Taylor & Francis Group, 2013. Chow CC, Mieler WF, Mittra and RA, Pollack JS. Retinal arterial macroaneurysms . In: Yanoff M, Duker JS. Ophthalmology (4th ed). Pittsburgh: Elsevier/Saunders, 2014. Chow CC, Mieler WF, Mittra RA, Pollack JS. Retinal arterial macroaneurysms (Ch 27). In: Duker JS, Yanoff M, Bakri S. Yanoff & Duker’s Retina and Vitreous. W B Saunders Co, 2014. Cortina MS, de la Cruz J, eds. Keratoprostheses and Artificial Corneas: Fundamentals and Surgical Applications. Berlin: Springer-Verlag, 2015. Eslani M, Movahedan A, Djalilian AR. Gene therapy. In: Scorsetti DH, Perez VL, Gomes JA, eds. Stem Cells in Ophthalmology. Philadelphia, PA: Jaypee Medical Inc.; 2015. Espana EM, Djalilian AR. Yoo SH, Romano A. En Face Optical Coherence Tomography imaging of corneal limbal stem cell niche. (Ch 7). In: Lumbroso, Bruno. Clinical En Face OCT Atlas. New Delhi: Jaypee-Highlights, 2013. Flower RW, Rathod R, Chau FY. Photocoagulation of AMD-associated CNV feeder vessels: An optimized approach. In: Lim JI, ed. Age-Related Macular Degeneration. 3rd rev. ed. Boca Raton: CRC Press/Taylor & Francis Group, 2013. Gandhi S, Jain S. The Anatomy and Physiology of the Cornea. In: Cortina MS, de la Cruz J, eds. Keratoprostheses and Artificial Corneas: Fundamentals and Surgical Applications. Berlin: Springer-Verlag, 2015. Ghanem RC, Allemann N, Azar DT. Phakic intraocular lenses. In: Yanoff M, Duker JS. Ophthalmology (4th ed). Pittsburgh: Elsevier/ Saunders, 2014. Ghanem RC, Allemann N, Azar DT. Phakic intraocular lenses. In: Yanoff M, Duker JS, Azar DT, Rosen ES. Yanoff & Duker’s Cataract and Refractive Surgery. W B Saunders Co, 2014. Goldstein DA, Patel SS Tessler HH. Episcleritis and scleritis. In: Yanoff M, Duker JS. Ophthalmology (4th ed). Pittsburgh: Elsevier/ Saunders, 2014. Goldstein MH, Sugar J, Kelmenson AT, Wadia HP, Edgington B. Anterior corneal dystrophies. In: Yanoff M, Duker JS. Ophthalmology (4th ed) Pittsburgh: Elsevier/ Saunders, 2014. Güell JL, Arrondo E, Cortina MS, Echevarria J, Gómez-Resa MV, Gris O, Hannush SB, Mateo C. Boston KPro Type I: Complications. In: Cortina MS, de la Cruz J, eds. Keratoprostheses and Artificial Corneas: Fundamentals and Surgical Applications. Berlin: Springer-Verlag, 2015. Hou JH, Young JA, Kommehl EW, de la Cruz J. Preoperative evaluation for refractive surgery. In: Yanoff M, Duker JS. Ophthalmology (4th ed). Pittsburgh: Elsevier/Saunders, 2014. Hou JH, Young JA, Kommehl EW, de la Cruz J. Preoperative evaluation for refractive surgery. In: Yanoff M, Duker JS, Azar DT, Rosen ES. Yanoff & Duker’s Cataract and Refractive Surgery. W B Saunders Co, 2014. Jain S, Tibrewal S, Kramarevsky N, Hardten DR. Excimer laser photorefractive keratectomy. In: Yanoff M, Duker JS. Ophthalmology (4th ed). Pittsburgh: Elsevier/ Saunders, 2014. Jain S, Tibrewal S, Kramarevsky N, Hardten DR. Excimer laser photorefractive keratectomy. In: Yanoff M, Duker JS, Azar DT, Rosen ES. Yanoff & Duker’s Cataract and Refractive Surgery. W B Saunders Co, 2014. Kang JJ, Cortina MS. Imaging of Boston Keratoprosthesis Type 1. In: Cortina MS, de la Cruz J, eds. Keratoprostheses and Artificial Corneas: Fundamentals and Surgical Applications. Berlin: Springer-Verlag, 2015. Kang JJ, Setabutr P. Oculoplastic Considerations in Boston Keratoprosthesis. In: Cortina MS, de la Cruz J, eds. Keratoprostheses and Artificial Corneas: Fundamentals and Surgical Applications. Berlin: Springer-Verlag, 2015. Knepper PA, Grybauskas A, Kuprys P, Skuran K, Samples JR. Biomarkers to predict glaucoma surgical success In: Samples JR, Ahmed J (eds). Surgical Innovations in Glaucoma. New York, 2014. (p 287-294). Kojima T, Primack JD, Azar DT. Intrastromal corneal ring segments and collagen crosslinking. In: Yanoff M, Duker JS. Ophthalmology (4th ed). Pittsburgh: Elsevier/Saunders, 2014. Lee SH, Cortina MS, de la Cruz J. History of the Artificial Cornea. In: Cortina MS, de la Cruz J, eds. Keratoprostheses and Artificial Corneas: Fundamentals and Surgical Applications. Berlin: Springer-Verlag, 2015. (eds.), Elsevier Saunders. 628629, 2014. Lim JI, ed. Age-Related Macular Degeneration. 3rd rev. ed. Boca Raton: CRC Press/Taylor & Francis Group, 2013. Moss HE. Vertical gaze palsy. In: MedLink Neurology, Gilman, S (editor-in-chief), MedLink Corporation, San Diego, 2013. Lim JI, Rosenblatt BJ, Benson WE. Diabetic Retinopathy (Ch 21). In: Duker, Jay S., Yanoff, Myron, and Bakri, Sophie. Yanoff & Duker’s Retina and Vitreous. W B Saunders Co, 2014. Patel RM, Putterman AM. Orbital Blowout Fractures. In: Ichhpujani P, Spaeth GL, Yanoff M, eds. Expert Techniques in Ophthalmic Surgery. New Delhi : Jaypee Brothers Medical Publishers Ltd., 2015. pp 645-652. Lim JI, Rosenblatt BJ, Benson WE. Diabetic retinopathy. In: Yanoff M, Duker JS. Ophthalmology (4th ed). Pittsburgh: Elsevier/ Saunders, 2014. Lim JI. AMD for the Cataract Surgeon. In: Cataract Surgery and Retinal Disease: Optimizing Visual Outcomes. Editor: Dennis Han MD. 2013. Lim JI. Neovascular age-related macular degeneration. In: Lim JI, ed. Age-Related Macular Degeneration. 3rd rev. ed. Boca Raton: CRC Press/Taylor & Francis Group, 2013. Mieler WF. Evidence-Based Medicine: The Prophylaxis and Treatment of Endophthalmitis. In: Kertes PJ, Johnson TM. Evidence-Based Eye Care (2nd ed.) Philadelphia: Lippincott Williams & Wilkins, 2014. Mittra RA, Mieler WF. Drug toxicity of the posterior segment. In: Ryan, Stephen J. Retina. London: Saunders/Elsevier, 2013 Moss HE . Combined third, fourth and sixth nerve palsies. In: MedLink Neurology, Gilman, S (editor-in-chief), MedLink Corporation, San Diego, 2013, 2014. Moss HE. Alexia without agraphia. In: MedLink Neurology, Gilman, S (editor-in-chief), MedLink Corporation, San Diego, 2014. Moss HE. Cogan syndrome. In: MedLink Neurology, Gilman, S (editor-in-chief), MedLink Corporation, San Diego, 2014. Moss HE. Eye movement disorders. In: Neurological Differential Diagnosis, Ettinger AB, Weisbrot D (eds.), Cambridge University Press, 2014. Moss HE. Horizontal gaze palsy. In: MedLink Neurology, Gilman, S (editor-in-chief), MedLink Corporation, San Diego, 2014. Moss HE. Optic neuritis. In: Conn’s Current Therapy. 65th edition, Bope ET, Kellerman R Putterman AM. Pearls for Muller’s Muscle-Conjunctival Resection with Upper Blepharoplasty. (Chapter 191). In: Hartstein ME, Massry GG, Holds JB, eds. Pearls and Pitfalls in Cosmetic Oculoplastic Surgery. New York: Springer, 2015, p65557. Rao NK, Goldstein MH, Tu EY. Dry Eye. In: Yanoff M, Duker JS. Ophthalmology (4th ed). Pittsburgh: Elsevier/Saunders, 2014. Shorter ES, Beyer JE, McMahon TT. Boston KPro Type 1: The Role of the Contact Lens. In: Cortina MS, de la Cruz J, eds. Keratoprostheses and Artificial Corneas: Fundamentals and Surgical Applications. Berlin: Springer-Verlag, 2015. Sivaraman KR, Allemann N. Anterior Segment Considerations in Boston Type I Keratoprosthesis. In: Cortina MS, de la Cruz J, eds. Keratoprostheses and Artificial Corneas: Fundamentals and Surgical Applications. Berlin: Springer-Verlag, 2015. Srur L, Selkin RP, Azar DT, Marten L, Wang MX, Karp CL. Excimer Laser Treatment of Corneal Pathology. In: Yanoff M, Duker JS. Ophthalmology (4th ed). Pittsburgh: Elsevier/Saunders, 2014. Taneri S, Mimura T, Azar DT. Current concepts, classification, and history of refractive surgery. In: Yanoff M, Duker JS. Ophthalmology (4th ed). Pittsburgh: Elsevier/Saunders, 2014. Taneri S, Mimura T, Azar DT. Current concepts, classification, and history of refractive surgery. In: Yanoff M, Duker JS, Azar DT, Rosen ES. Yanoff & Duker’s Cataract and Refractive Surgery. W B Saunders Co, 2014. Tobaigy FM, Fahd D, Chamon W. Wavefront-based Excimer Laser Refractive Surgery. In: Yanoff M, Duker JS. Ophthalmology (4th ed). Pittsburgh: Elsevier/ Saunders, 2014. Tobaigy FM, Fahd D, Chamon W. Wavefront-based Excimer Laser Refractive Surgery. In: Yanoff M, Duker JS, Azar DT, Rosen ES. Yanoff & Duker’s Cataract and Refractive Surgery. W B Saunders Co, 2014. Vajaranant TS, Aref AA. Pars Pana Tube Shunt Surgery in Keratoprosthesis. In: Aref AA, Varma, R, eds. Advanced Glaucoma Surgery. Basel: Birkhauser Verlag AG, 2015. Walonker AF, Diddie KR, Niec M. Clinical research trials. In: Lim JI, ed. Age-Related Macular Degeneration. 3rd rev. ed. Boca Raton: CRC Press/Taylor & Francis Group, 2013. Wilensky, J, McGlynn RH. Late Bleb Leeks. In: Shaarawy, Tarek M. Glaucoma. (Vol. 2: Surgical management). London: Saunders Elsevier, 2015. Yanoff M, Duker JS, Azar DT, Rosen ES. Yanoff & Duker’s Cataract and Refractive Surgery. W B Saunders Co, 2014. Sugar J, Batta P. Keratoconus and other ectasias. In: Yanoff M, Duker JS. Ophthalmology (4th ed.) Pittsburgh: Elsevier/Saunders, 2014. Sugar J, Wadia HP, Vasaiwala RA. Congenital corneal anomalies. In: Yanoff M, Duker JS. Ophthalmology (4th ed.) Pittsburgh: Elsevier/Saunders, 2014. Sugar J, Wadia HP, Vasaiwala RA. Stromal corneal dystrophies. In: Yanoff M, Duker JS. Ophthalmology (4th ed.) Pittsburgh: Elsevier/Saunders, 2014. OneVision | 47 IN MEMORIUM JOHN H. PANTON, MD, (Res’ 57) a longtime friend and gracious benefactor to the Department of Ophthalmology and Visual Sciences, passed away on December 20, 2015. Mary Panton, John’s wife of 60 years, passed away in June, 2015. Together, they cherished both their family and giving back in meaningful ways. A 1950 graduate of the University of Athens Medical School, Dr. Panton completed his internship at Mercy Hospital-Loyola University and his residency in ophthalmology at the University of Illinois College of Medicine. Dr. Panton often credited his success to his UIC training. He opened his practice in 1960, and in time was joined by two of his sons, Drs. Peter (Res ’86) and Robert Panton (Res ’90), and his daughter, Dr. Elizabeth Panton-Karkazis. The Panton family have been giving to the Department of Ophthalmology since the 1980s. Their great generosity has benefited the Lions of Illinois Eye Research Institute, endowed professorships and most recently the Panton Family Professorship. In 2007, Peter and Robert Panton joined the children of three other resident alumni to establish the Four Fathers Lecture in Ophthalmology. John and Mary Panton also supported the IEEI Library, and the Panton Family Scholarship in the College of Medicine. John and Mary Panton are survived by their four children, Peter (Estelle) Panton, Evans (Laura) Panton, Robert (Marika) Panton, and Elizabeth (Frank) Karkazis; and 11 grandchildren. GERHARD CLESS, a generous benefactor and longtime friend of the Department of Ophthalmology and Visual Sciences, passed away on January 22, 2016, at the age of 75. Gerhard was an innovator, entrepreneur and family man. Born and raised in Germany, Gerhard met his wife Ruth of 51 years in 1960, after which they emigrated from Germany to Chicago. He co-founded Data Specialties, the forerunner to Lincolnshire based Zebra Technologies which developed the first barcode printers in the early 1980s. Mr. Cless and his family have been generous supporters of the Department of Ophthalmology & Visual Sciences since 2000. The Cless Family Foundation funded an array of projects and needs for the department including vision research and education programs, support for acquisitions of advanced microscopy, recruitment of retina faculty, clinical studies in the diseases of the retina and macula, as well as support for a retina fellowship. Prior gifts also established the Gerhard Cless Endowed Lecture in 2003 and the Cless Best of the Best Award in 2008. The Cless Family Professorship in Ophthalmology was established in 2013, and most recently Gerhard and Ruth Cless made a transformative gift to establish the Cless Family Ophthalmic Surgical Training and Simulation Center. Mr. Cless is survived by his wife, Ruth; children, Martin (Kristin) Cless, Jennifer (Stephen) Zehr, Stephen (Anne) Cless and Bryan (Megan) Cless; and 10 grandchildren. INVESTITURE OF WILLIAM F. MIELER, MD, FARVO FIRST RECIPIENT OF THE CLESS FAMILY PROFESSORSHIP IN OPHTHALMOLOGY Dr. Mark Rosenblatt, Dr. William Mieler and Dean Dimitri Azar On November 18, 2014, Dr. William Mieler, Professor of Ophthalmology and Vice Chair for Education, was invested as the inaugural Cless Family Professor among members of the Cless Family, distinguished faculty and UIC Leadership. The Cless Family Professorship was established thanks to the generosity of the Cless Family Foundation. Endowed professorships are one of the highest honors bestowed by the academic community. Income from these funds provides research support and resources for program development that enable educators to pursue projects at the forefront of their fields. Dr. Mieler is an expert in treating diseases of the macula, retina and vitreous. Throughout his stellar academic career Dr. Mieler has been involved in cutting edge research, published extensively, and demonstrated an outstanding commitment to education in ophthalmology. Dr. Mieler has received multiple awards from the American Academy of Ophthalmology. In 2013 the Macula Society awarded him the prestigious J. Donald Gass Medal for extraordinary contributions to diseases of the macula. 48 IN THIS ISSUE 1 2 4 6 8 10 28 32 34 36 38 40 48 49 Leadership Shedding Light on the “Bionic Eye” Artificial Cornea Program Flourishes PROSE Clinic Makes Strides Stem Cells and Sight Clinical Services/Faculty Research Faculty Sponsored Research Clinical Investigations and Trials Giving Education Publications In Memoriam; Investiture Cless Lab LEADERSHIP Mark I. Rosenblatt, MD, PhD, MBA | Professor and Department Head Lions of Illinois/Charles I. Young Chair in Ocular Research Joel Sugar, MD | Vice Chair for Clinical Operations Joel Sugar MD Professor in Ophthalmology William F. Mieler, MD, FARVO | Vice Chair for Education Cless Family Professor in Ophthalmology Mahnaz Shahidi, PhD | Vice Chair for Research Morton F. Goldberg MD FACS Professor in Ophthalmology Timothy McMahon, OD, FAAO | Vice Chair for Optometry Professor of Ophthalmology R. V. Paul Chan, MD, FACS | Vice Chair for Global Ophthalmology Professor of Ophthalmology CLESS FAMILY OPHTHALMIC SURGICAL TRAINING AND SIMULATION CENTER The Illinois Eye and Ear Infirmary is known as a leader in the field of ophthalmic training in the region and in the nation. One component of this leadership is providing the highest level of surgical training that is available. This year we inaugurated the 9 station state-of-the-art Cless Family Ophthalmic Surgical Training and Simulation Center (Cless Lab), the premier center for ophthalmic surgical training in the Midwest. The Cless Lab will be home to surgical training courses, webcasting and live surgery streaming as well as surgical simulation technology. A generous investment made by the Cless Family Foundation, along with support from faculty and alumni, made this vision a reality. Establishing the Cless Lab is an enormous advancement in how we train our residents and surgical fellows. It is an active learning environment allowing for a virtual-reality simulation experience within which attention to the finest, most minute details, such as the careful orchestration of hand and foot instrument manipulation, can be perfected without putting patients at risk. It will no doubt significantly increase trainees’ aptitude and confidence when performing in a live operating room. The virtual connections this equipment makes possible will enable us to examine how fellow surgeons from all corners of the world do work, and repeat it right here. This exposure to new information and practices will fuel the innovation and breakthroughs that will happen here first. And, when they do, we can share them with the rest of the world right from the Cless Lab. We now are able to provide services few places in the world can offer. Our faculty, residents, fellows, alumni and local ophthalmologists can learn more, innovate faster and pioneer surgical curriculum because of these connections. CREDITS Writers Lisa Holton Margaret Doyle Editor Laurie Walker Designer Lisa Birmingham Contributors Margaret Chervinko, Lauren Hughes, Cristina Lee, Kristen Scheurich, Laurie Walker Photography Cathy Carroll, Joshua Clark, Roberta Dupuis-Devlin, Mark Janowicz On the cover Visionary by Gwyn Newcombe Left to right: Drs. Sugar, McMahon, Shahidi, Mieler and Rosenblatt—not pictured, Dr. Chan 1855 West Taylor Street Chicago, IL 60612 Non-Profit Org. U.S. Postage PAID Permit No. 4860 symposia & events 2016 February 20-26, 2016 9th Annual Illinois Eye Review Friday, April 22, 2016 9th Annual Retina Symposium Wednesday, May 25, 2016 2016 Spring Glaucoma Symposium Friday, June 17, 2016 40th Annual Alumni / Resident Day Sunday, October 16, 2016 Alumni Reception at the AAO Meeting Saturday, October 22, 2016 The Chicago Chronic GVHD Meeting http://eyecare.uic.edu l www.chicago.medicine.uic.edu/eye Proud Community Partner ONE VISION2014-15 Department of Ophthalmology and Visual Sciences Illinois Eye and Ear Infirmary University of Illinois College of Medicine AND EAR INFIRMARY