Download BIOLOGI KANKER NO Topic Sub

BIOLOGI KANKER
NO
1
2
Topic
The Nature of
Cancer
Tumor Viruses
3
Cellular
Oncogenes
4
Growth Factors,
Receptors, and
Cancer
5
Cytoplasmic
Signaling Circuitry
Programs
Many of the Traits
of Cancer
Tumor Suppressor
Genes
6
7
pRb and Control
of the Cell Cycle
Clock
8
p53 and
Apoptosis: Master
Guardian and
Executioner
9
Eternal Life: Cell
Immortalization
and
Tumorigenesis
Sub-Topic
Teaching method
Evaluation
Competency
Student having
sufficient
knowledge on the
topic
Definition of cancer, classification
of cancer, tumor staging
Tumor viruses induce multiple
changes in cell phenotype
including acquisition of
tumorigenicity; Tumor virus
genomes persist in virustransformed cells
by becoming part of host-cell DNA
Oncogenes discovered in human
tumor cell lines are
related to those carried by
transforming retroviruses; Protooncogenes can be activated by
genetic changes
affecting either protein expression
or structure
An altered growth factor receptor
can function as an
Oncoprotein; A growth factor gene
can become an oncogene:
the case of sis
SCL, presentation,
discussion
SCL, presentation,
discussion
Presentation, Quiz
SCL, presentation,
discussion
Presentation, Quiz
Student having
sufficient
knowledge to
analysis
oncogenesis
SCL, presentation,
discussion
Presentation, Quiz
A signaling pathway reaches from
the cell surface into
the nucleus; The Wnt–β-catenin
pathway contributes to cell
proliferation
Promoter methylation represents
an important
mechanism for inactivating tumor
suppressor genes; Tumor
suppressor genes and proteins
function in
diverse ways
Cell growth and division is
coordinated by a complex
array of regulators; A variety of
mitogenic signaling pathways
control
the phosphorylation state of pRb
p53 is discovered to be a tumor
suppressor gene; p53 functions as a
transcription factor that halts cell
cycle advance in response to DNA
damage and
attempts to aid in the repair
process
Cell-physiologic stresses impose a
limitation on
Replication; The proliferation of
cultured cells is also limited by the
telomeres of their chromosomes
SCL, presentation,
discussion
Presentation, Quiz
SCL, presentation,
discussion
Presentation, Quiz
Student having
sufficient
knowledge to
analysis the link
between groth
factor and cancer
Student having
sufficient
knowledge to
understand cancer
signaling
Student having
sufficient
knowledge to
understand Tumor
Suppressor genes
SCL, presentation,
discussion
Presentation, Quiz
SCL, presentation,
discussion
Presentation, Quiz
SCL, presentation,
discussion
Presentation, Quiz
Presentation, Quiz
Student having
sufficient
knowledge to
analysis the link
between growth
factor and cancer
Student having
sufficient
knowledge on the
topic
Student having
sufficient
knowledge to
understand Cell
immortalization
10
Multi-Step
Tumorigenesis
11
Maintenance of
Genomic Integrity
and the
Development of
Cancer
12
Dialogue Replaces
Monologue:
Heterotypic
Interactions and
the Biology of
Angiogenesis
13
Moving Out:
Invasion and
Metastasis
14
Crowd Control:
Tumor
Immunology
and
Immunotherapy
Cells accumulate genetic and
epigenetic alterations
as tumor progression proceeds;
Tumor stem cells further
complicate the Darwinian
model of clonal succession and
tumor progression
Apoptosis, drug pumps, and DNA
replication
mechanisms offer tissues a way to
minimize the
accumulation of mutant stem cells;
Cells deploy a variety of defenses to
protect DNA
molecules from attack by mutagens
The cells forming cancer cell lines
develop without
heterotypic interactions and
deviate from the behavior
of cells within human tumors;
Endothelial cells and the vessels
that they form ensure
tumors adequate access to the
circulation
EMTs are programmed by
transcription factors that
orchestrate key steps of
embryogenesis; Small Ras-like
GTPases control cellular processes
such as adhesion, cell shape, and
cell motility
Regulatory T cells are able to
suppress major
components of the adaptive
immune response; Tumorassociated transplantation antigens
may
also evoke anti-tumor immunity
SCL, presentation,
discussion
Presentation, Quiz
Student having
sufficient
knowledge to
understand Tumor
stepping
SCL, presentation,
discussion
Presentation, Quiz
Student having
sufficient
knowledge to
understand
genomeic integrity
in cancer
SCL, presentation,
discussion
Presentation, Quiz
Student having
sufficient
knowledge to
understand
angiogenesis
SCL, presentation,
discussion
Presentation, Quiz
Student having
sufficient
knowledge to
understand Tumor
metastatsis
SCL, presentation,
discussion
Presentation, Quiz
Student having
sufficient
knowledge to
understand Tumor
immunology and
therapy
References:
1. Robert A. Weinberg, Robert A Weinberg , The Biology of Cancer 2nd Edition; Gerland Science, 2014
2. Raymond W. Ruddon, Cancer biology, Oxford University press, 2007
3. Dmitry I. Gabrilovich, H. Lee Moffitt, Cancer Center Tumor-Induced Immune Suppression, springer science, 2008
4. F.Macdonald, C.H.J.Ford, A.G.Casson, Molecular biology of Cancer, Bios scientific publisher, 2004