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DMPK Scientist Design, conduct and analyze in vivo DMPK study work to support our drug discovery and development (preclinical) projects. Interpret bioanalytical/pharmacokinetic findings, write reports, make presentations, and communicate with scientists. Requires PhD or MS and 2+ years industry experience with in vivo DMPK; knowledge of biochemistry or kinetics and hands-on DMPK skills including bioanalytical method development and metabolites identification using HPLC and LC/MS/MS; drug quantitation in various matrices such as plasma and tissues; sample preparation solid/liquid extraction, and computational PK analysis/modeling using Winnonlin. Previous hands-on animal experience with IV or PO administration, blood collection and preformulation a plus. Boston Area Description: The individual will be able to design, plan, prioritize and conduct in vitro drug metabolism and drug transport experiments to support project efforts and contribute to the drug discovery. The individual will have proven skills in areas of in vitro screening for discovery lead compounds. The candidate will be responsible for generating protocols, data analysis, writing reports and presenting data in the project meetings. Works independently, represents the group and recommend research strategies in the project meetings, maintains satisfactory rate of output and quality of work while meeting deadlines. The individual will interact with chemists, PK and bioanalytical scientists, and with discovery project teams to supply input on the implications of in vitro results on project goals. The candidate must have 0-4 years of post-doctoral experience in a drug discovery and development environment. ESSENTIAL DUTIES AND RESPONSIBILITIES: Responsible for in vitro assays including metabolic stability, reaction phenotype, CYP inhibition, protein binding and drug transporters. The candidates must have demonstrated skills in at least in one of the followings: (i) Caco-2 cell model as applied to drug absorption and other cell based in vitro assays including human hepatocytes; (ii) Hands-on experience on mass spectrometry as applied to in vitro & in vivo drug metabolism. Working knowledge of other instrumentation including HPLC, radiometric assay, LSC, fluorescence, 96-well plate reader is required. Must be able to supervise 1-2 research associates. Excellent communication skills and ability to perform as an effective, flexible and self-assured team player. Well organized, good interpersonal skills, closely interacts with DMPK scientists and must be able to work with multidisciplinary project teams. Must possess strong scientific problem solving skills and have good publication records. Job Requirements: Education: Ph.D. in related scientific field Experience: 0-4 years of post-doctoral experience Specific Skills: Thorough understanding of HTS for discovery lead compounds for metabolism, metabolite ID and Caco-2 cell based transport studies. Good understanding of P450 reaction phenotype, use of hepatocytes and phase II conjugation. Just a Reminder. I am a recruiter that focuses only in DMPK and Clinical Pharmacology SAN DIEGO AREA T.J. Elder DMPK & Clinical Pharmacology PharmaLogics Recruiting 220 Forbes Road Suite 108 Braintree, MA 02184 P: (781) 848-5500 x107 F: (781) 848-5276 mailto:[email protected] www.pharmalogicsrecruiting.com